{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:04:51Z","timestamp":1789812291176,"version":"4.0.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[1998,1]]},"DOI":"10.1006\/nbdi.1998.0167","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T15:46:43Z","timestamp":1032364003000},"page":"398-409","source":"Crossref","is-referenced-by-count":26,"title":["Presenilins Upregulate Functional K+Channel Currents in Mammalian Cells"],"prefix":"10.1006","volume":"4","author":[{"given":"Sacha A.","family":"Malin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-X.Athena","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Jafari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison M.","family":"Goate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne M.","family":"Nerbonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/nbdi.1998.0167_NB980167RF1","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0896-6273(00)80230-5","article-title":"Familial Alzheimer's Disease-linked presenilin-1 variants elevate A\u03b21-42\/1-40 ratiosin vitroin vivo","volume":"17","author":"Borchelt","year":"1996","journal-title":"Neuron"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF2","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1751-1097.1995.tb08712.x","article-title":"Green fluorescent protein","volume":"62","author":"Chalfie","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF3","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/ng1095-219","article-title":"The structure of the presenilin 1 (S182) and identification of six novel mutations in early onset AD families","volume":"11","author":"Clark","year":"1995","journal-title":"Nature Genet."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF4","first-page":"1797","article-title":"Widespread neuronal expression of the presenilin-1 early onset Alzheimer's disease gene in the murine brain","volume":"148","author":"Cribbs","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF5","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0896-6273(00)80232-9","article-title":"Protein topology of presenilin 1","volume":"17","author":"Doan","year":"1996","journal-title":"Neuron"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF6","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/383710a0","article-title":"Increased amyloid-\u03b242(43) in brains of mice expressing mutant presenilin 1","volume":"383","author":"Duff","year":"1996","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/(SICI)1097-4547(19960801)45:3<308::AID-JNR13>3.0.CO;2-#","article-title":"Identification and neuron-specific expression of the S182\/Presenilin I protein in human and rodent brains","volume":"45","author":"Elder","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF8","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1073\/pnas.90.17.8209","article-title":"Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer's disease","volume":"90","author":"Etcheberrigaray","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF9","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1126\/science.8146663","article-title":"Soluble \u03b2-amyloid induction of Alzheimer's phenotype for human fibroblast K+","volume":"264","author":"Etcheberrigaray","year":"1994","journal-title":"Science"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/379074a0","article-title":"Activation of K+","volume":"379","author":"Furukawa","year":"1996","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/349704a0","article-title":"Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease","volume":"249","author":"Goate","year":"1991","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0006-3495(96)79570-X","article-title":"\u03b2-amyloid peptide blocks the fast inactivating K+","volume":"79","author":"Good","year":"1996","journal-title":"Biophys. J."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF13","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1085\/jgp.86.3.353","article-title":"Photoinduced removal of nifedipine reveals mechanisms of calcium antagonist action on single heart cells","volume":"86","author":"Gurney","year":"1985","journal-title":"J. Gen. Physiol."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF14","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/42571","article-title":"K+","volume":"387","author":"Hoffman","year":"1997","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/0896-6273(90)90095-W","article-title":"Lipofection of cDNAs in the embryonic vertebrate central nervous system","volume":"4","author":"Holt","year":"1990","journal-title":"Neuron"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF16","doi-asserted-by":"crossref","unstructured":"Jarrett, J. T. Berger, E. P. Lansbury, P. T. Jr. 1993, The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's Disease, Biochemistry, 32, 4693, 4697, 1993","DOI":"10.1021\/bi00069a001"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1038\/nm0296-224","article-title":"Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells","volume":"2","author":"Kovacs","year":"1996","journal-title":"Nature Med."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF18","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jama.1997.03540340059034","article-title":"Exploring the etiology of Alzheimer's disease using molecular genetics","volume":"277","author":"Lendon","year":"1997","journal-title":"J. Am. Med. Assoc."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF19","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/377351a0","article-title":"Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene","volume":"377","author":"Levitan","year":"1995","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF20","doi-asserted-by":"crossref","unstructured":"Levitan, D. Doyle, T. G. Brousseau, D. Lee, M. K. Thinakaran, G. Slunt, H. H. Sisodia, S. A. Greenwald, I. 1996, Assessment of normal and mutant human presenilin function inCaenorhabditis elegans, Proc. Natl. Acad. Sci. USA, 93, 14940, 14944, 1996","DOI":"10.1073\/pnas.93.25.14940"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF21","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.7638621","article-title":"A familial Alzheimer's disease locus on chromosome 1","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF22","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.7638622","article-title":"Candidate gene for the chromosome 1 familial Alzheimer's disease locus","volume":"269","author":"Levy-Lahad","year":"1995","journal-title":"Science"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF23","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/S0896-6273(00)80231-7","article-title":"Membrane topology of theC. elegans sel-12","volume":"17","author":"Li","year":"1996","journal-title":"Neuron"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0896-6273(93)90270-2","article-title":"Interaction of the 43 kD postsynaptic protein with all subunits of the muscle nicotinic acetylcholine receptor","volume":"11","author":"Maimone","year":"1993","journal-title":"Neuron"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF25","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0014-5793(96)00608-4","article-title":"Characterization of human presenilin 1 using N-terminal specific antibodies: Evidence that Alzheimer mutations affect processing","volume":"389","author":"Mercken","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0092-8674(77)90320-8","article-title":"Continuous cell lines derived from chemically-induced tumors of Japanese quails","volume":"11","author":"Moscovici","year":"1977","journal-title":"Cell"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF27","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/00001756-199512000-00071","article-title":"A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin gene","volume":"7","author":"Perez-Tur","year":"1995","journal-title":"Neuroreport"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1006\/nbdi.1997.0129","article-title":"Presenilin proteins undergo heterogeneous endoproteolysis between thr291299","volume":"3","author":"Podlisny","year":"1997","journal-title":"Neurobiol. Disease"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/376775a0","article-title":"Familial Alzheimer's disease in kindred with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene","volume":"376","author":"Rogaev","year":"1995","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF30","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1126\/science.1411576","article-title":"Genetic linkage evidence for a familial Alzheimer's disease locus on chromosome 14","volume":"258","author":"Schellenberg","year":"1995","journal-title":"Science"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/nm0896-864","article-title":"Secreted amyloid \u03b2-protein similar to that in the senile plaques of Alzheimer's disease is increasedin vivo","volume":"2","author":"Scheuner","year":"1996","journal-title":"Nature Med."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF32","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/375754a0","article-title":"Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease","volume":"375","author":"Sherrington","year":"1995","journal-title":"Nature"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0304-3940(93)90519-Q","article-title":"Amyloid \u03b2 peptides act directly on single neurons","volume":"150","author":"Simmons","year":"1993","journal-title":"Neurosci. Letts."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF34","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.90.5.1977","article-title":"Apolipoprotein E: High avidity binding to \u03b2-amyloid and increased frequency of type 4 allele in late onset familial Alzheimer's Disease","volume":"90","author":"Strittmatter","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF35","unstructured":"Terry, R. D. Wisniewski, H. M. 1975, Pathology and pathogenesis of dementia, Neurological and Sensory Disorders in the Elderly, 135, 150, Statton, N.Y."},{"key":"10.1006\/nbdi.1998.0167_NB980167RF36","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80291-3","article-title":"Endoproteolysis of presenilin 1 and accumulation of processed derivativesin vivo","volume":"17","author":"Thinakaran","year":"1996","journal-title":"Neuron"},{"key":"10.1006\/nbdi.1998.0167_NB980167RF37","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0896-6273(00)80115-4","article-title":"Mechanisms of neuronal degeneration in Alzheimer's disease","volume":"16","author":"Yankner","year":"1996","journal-title":"Neuron"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999619890167X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999619890167X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T09:45:55Z","timestamp":1576489555000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999619890167X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,1]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1998,1]]}},"alternative-id":["S096999619890167X"],"URL":"https:\/\/doi.org\/10.1006\/nbdi.1998.0167","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[1998,1]]}}}