{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:41:08Z","timestamp":1760852468812,"version":"build-2065373602"},"reference-count":39,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2000,8,1]],"date-time":"2000-08-01T00:00:00Z","timestamp":965088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2000,8]]},"DOI":"10.1006\/nbdi.2000.0307","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T15:46:43Z","timestamp":1032364003000},"page":"483-491","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine"],"prefix":"10.1006","volume":"7","author":[{"given":"C.","family":"Rosenbaum","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Kamleiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Grafe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Kluwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.-F.","family":"Mautner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.W.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.O.","family":"Hanemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/nbdi.2000.0307_RF1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-4695(199908)40:2<214::AID-NEU7>3.0.CO;2-0","article-title":"Modulation of HERG current and herg gene expression during retinoic acid treatment of human neuroblastoma cells: Potentiating effects of BDNF","volume":"40","author":"Arcangeli","year":"1999","journal-title":"J. Neurobiol."},{"key":"10.1006\/nbdi.2000.0307_RF2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/jnr.490370412","article-title":"Differential expression of two mRNA species indicates a dual function of peripheral myelin protein PMP22 in cell growth and myelination","volume":"37","author":"Bosse","year":"1994","journal-title":"J. Neurosci. Res."},{"key":"10.1006\/nbdi.2000.0307_RF3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1113\/jphysiol.1989.sp017455","article-title":"The role of potassium channels in Schwann cell proliferation in Wallerian degeneration of explant rabbit sciatic nerves","volume":"408","author":"Chiu","year":"1989","journal-title":"J. Physiol."},{"key":"10.1006\/nbdi.2000.0307_RF4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/307465a0","article-title":"Voltage-gated T lymphocytes: A role in mitogenesis?","volume":"307","author":"DeCoursey","year":"1984","journal-title":"Nature"},{"key":"10.1006\/nbdi.2000.0307_RF5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0079-6107(93)90005-5","article-title":"Role of potassium channels in mitogenesis","volume":"59","author":"Dubois","year":"1993","journal-title":"Prog. Biophys. Mol. Biol."},{"key":"10.1006\/nbdi.2000.0307_RF6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1001\/jama.1997.03550010065042","article-title":"The diagnostic evaluation and multidisciplinary management of neurofibromatosis 1 and neurofibromatosis 2","volume":"278","author":"Gutmann","year":"1997","journal-title":"JAMA"},{"key":"10.1006\/nbdi.2000.0307_RF7","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/hmg\/8.2.267","article-title":"Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading","volume":"8","author":"Gutmann","year":"1999","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/nbdi.2000.0307_RF8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF00656997","article-title":"Improved patch clamp techniques for high resolution current recording from cells and cell-free membrane patches","volume":"391","author":"Hamill","year":"1981","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1006\/nbdi.2000.0307_RF9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/(SICI)1098-1136(199806)23:2<89::AID-GLIA1>3.0.CO;2-Z","article-title":"Improved culture methods to expand Schwann cells with altered growth behaviour from CMT1A patients","volume":"23","author":"Hanemann","year":"1998","journal-title":"GLIA"},{"key":"10.1006\/nbdi.2000.0307_RF10","series-title":"Neurofibromatosis. 1. A Clinical and Genetic Overview","first-page":"160","author":"Huson","year":"1994"},{"key":"10.1006\/nbdi.2000.0307_RF11","first-page":"73","article-title":"Neurofibromatosis 2 antisense oligonucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells","volume":"13","author":"Huynh","year":"1996","journal-title":"Oncogene"},{"key":"10.1006\/nbdi.2000.0307_RF12","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/(SICI)1098-1136(199811)24:3<313::AID-GLIA5>3.0.CO;2-2","article-title":"Voltage-dependent membrane currents of cultured human neurofibromatosis type 2 Schwann cells","volume":"24","author":"Kamleiter","year":"1998","journal-title":"GLIA"},{"key":"10.1006\/nbdi.2000.0307_RF13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1007\/s004390050255","article-title":"Identification of NF2 germ-line mutations and comparison with neurofibromatosis 2 phenotypes","volume":"98","author":"Kluwe","year":"1996","journal-title":"Hum. Genet."},{"key":"10.1006\/nbdi.2000.0307_RF14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1073\/pnas.68.4.820","article-title":"Mutation and cancer: Statistical study of retinoblastoma","volume":"68","author":"Knudson","year":"1971","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/nbdi.2000.0307_RF15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1113\/jphysiol.1989.sp017564","article-title":"Voltage-dependent potassium channels in mouse Schwann cells","volume":"411","author":"Konishi","year":"1989","journal-title":"J. Physiol."},{"key":"10.1006\/nbdi.2000.0307_RF16","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1101\/gad.11.10.1253","article-title":"The NF2 tumor suppressor gene product is essential for extraembryonic development immediately prior to gastrulation","volume":"11","author":"McClatchey","year":"1997","journal-title":"Genes Dev."},{"key":"10.1006\/nbdi.2000.0307_RF17","series-title":"Antiarrhythmic Drugs","first-page":"683","author":"Moe","year":"1975"},{"key":"10.1006\/nbdi.2000.0307_RF18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/jn.1991.65.3.715","article-title":"Excitatory amino acid response in isolated spiral ganglion cells of guinea pig cochlea","volume":"65","author":"Nakagawa","year":"1991","journal-title":"J. Neurophysiol."},{"key":"10.1006\/nbdi.2000.0307_RF19","first-page":"105","article-title":"A role for K+ channels in cell proliferation","volume":"9","author":"Nilius","year":"1994","journal-title":"News Physiol. Sci."},{"key":"10.1006\/nbdi.2000.0307_RF20","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1098-1136(199802)22:2<113::AID-GLIA2>3.0.CO;2-8","article-title":"Effect of specific ion channel blockers on cultured Schwann cell proliferation","volume":"22","author":"Pappas","year":"1998","journal-title":"GLIA"},{"key":"10.1006\/nbdi.2000.0307_RF21","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1097\/00001756-199412300-00049","article-title":"Reduction of glial proliferation by K+ channel blockers is mediated by changes in pHi","volume":"6","author":"Pappas","year":"1994","journal-title":"NeuroReport"},{"key":"10.1006\/nbdi.2000.0307_RF22","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1038\/sj.onc.1202141","article-title":"Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human schwannoma cells","volume":"16","author":"Pelton","year":"1998","journal-title":"Oncogene"},{"key":"10.1006\/nbdi.2000.0307_RF23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1006\/nbdi.1998.0179","article-title":"Isolation and characterization of Schwann cells from neurofibromatosis type 2 patients","volume":"5","author":"Rosenbaum","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1006\/nbdi.2000.0307_RF24","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/329246a0","article-title":"Genetic linkage analysis of bilateral acoustic neurofibromatosis to a DNA marker on chromosome 22","volume":"363","author":"Rouleau","year":"1987","journal-title":"Nature"},{"key":"10.1006\/nbdi.2000.0307_RF25","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/363515a0","article-title":"Alteration in a new gene encoding a putative membrane organizing protein causes neurofibromatosis type 2","volume":"363","author":"Rouleau","year":"1993","journal-title":"Nature"},{"key":"10.1006\/nbdi.2000.0307_RF26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0898-6568(91)90062-Y","article-title":"A quantitative analysis of the role of K+channels in mitogenesis of neuroblastoma cells","volume":"3","author":"Rouzaire-Dubois","year":"1991","journal-title":"Cell Signal."},{"key":"10.1006\/nbdi.2000.0307_RF27","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1469-7793.1998.093bz.x","article-title":"K+ channel block-induced mammalian neuroblastoma cell swelling: A possible mechanism to influence proliferation","volume":"510","author":"Rouzaire-Dubois","year":"1998","journal-title":"J. Physiol."},{"key":"10.1006\/nbdi.2000.0307_RF28","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1093\/hmg\/3.6.885","article-title":"Mutations of the neurofibromatosis type 2 gene and lack of the gene product in vestibular schwannomas","volume":"3","author":"Sainz","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/nbdi.2000.0307_RF29","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/00006123-199704000-00007","article-title":"Management of vestibular schwannomas (acoustic neuromas): Auditory and facial nerve function after resection of 120 vestibular schwannomas in patients with neurofibromatosis 2","volume":"40","author":"Samii","year":"1997","journal-title":"Neurosurgery"},{"key":"10.1006\/nbdi.2000.0307_RF30","doi-asserted-by":"crossref","first-page":"5419","DOI":"10.1073\/pnas.84.15.5419","article-title":"Molecular genetic approach to human meningioma: Loss of genes on chromosome 22","volume":"84","author":"Seizinger","year":"1987","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/nbdi.2000.0307_RF31","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1126\/science.3105060","article-title":"A common pathogenic mechanism for the three tumor types in bilateral acoustic neurofibromatosis","volume":"236","author":"Seizinger","year":"1987","journal-title":"Science"},{"key":"10.1006\/nbdi.2000.0307_RF32","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1038\/sj.onc.1201418","article-title":"Interdomain binding mediates tumor growth suppression by the NF2 gene product","volume":"15","author":"Sherman","year":"1997","journal-title":"Oncogene"},{"key":"10.1006\/nbdi.2000.0307_RF33","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.1523\/JNEUROSCI.18-24-10398.1998","article-title":"Heteromultimeric delayed-rectifier K+ channels in Schwann cells: Developmental expression and role in cell proliferation","volume":"18","author":"Sobko","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1006\/nbdi.2000.0307_RF34","doi-asserted-by":"crossref","first-page":"5942","DOI":"10.1523\/JNEUROSCI.19-14-05942.1999","article-title":"Modulation of glioma cell migration and invasion using Cl(\u2212) and K(+) ion channel blockers","volume":"19","author":"Soroceanu","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1006\/nbdi.2000.0307_RF35","doi-asserted-by":"crossref","first-page":"23387","DOI":"10.1016\/S0021-9258(17)31525-9","article-title":"An anti-Ras function of neurofibromatosis type 2 gene product (NF2\/Merlin)","volume":"269","author":"Tikoo","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1006\/nbdi.2000.0307_RF36","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/0092-8674(93)90406-G","article-title":"A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor","volume":"72","author":"Trofatter","year":"1993","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0307_RF37","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/hmg\/3.1.147","article-title":"The neurofibromatosis type 2 (NF2) gene is inactivated in schwannomas","volume":"3","author":"Twist","year":"1994","journal-title":"Hum. Mol. Genet."},{"key":"10.1006\/nbdi.2000.0307_RF38","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.1993.sp019872","article-title":"Mitogenic factors regulate ion channels in Schwann cells cultured","volume":"470","author":"Wilson","year":"1993","journal-title":"J. Physiol."},{"key":"10.1006\/nbdi.2000.0307_RF39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s002329900135","article-title":"Potassium channels, proliferation and G1 progression","volume":"154","author":"Wonderlin","year":"1996","journal-title":"J. Membr. Biol."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996100903073?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996100903073?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T04:58:19Z","timestamp":1760849899000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996100903073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,8]]},"references-count":39,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2000,8]]}},"alternative-id":["S0969996100903073"],"URL":"https:\/\/doi.org\/10.1006\/nbdi.2000.0307","relation":{},"ISSN":["0969-9961"],"issn-type":[{"type":"print","value":"0969-9961"}],"subject":[],"published":{"date-parts":[[2000,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced Proliferation and Potassium Conductance of Schwann Cells Isolated from NF2 Schwannomas Can Be Reduced by Quinidine","name":"articletitle","label":"Article Title"},{"value":"Neurobiology of Disease","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/nbdi.2000.0307","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2000 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}