{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:24:15Z","timestamp":1773876255515,"version":"3.50.1"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/nbdi.2000.0362","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T19:46:43Z","timestamp":1032378403000},"page":"78-89","source":"Crossref","is-referenced-by-count":27,"title":["The Endosomal Trafficking of Apolipoprotein E3 and E4 in Cultured Human Brain Neurons and Astrocytes"],"prefix":"10.1006","volume":"8","author":[{"given":"Robert M.","family":"DeKroon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia J.","family":"Armati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/nbdi.2000.0362_RF1","first-page":"581","article-title":"Characterization of three human apolipoprotein E isoforms (E2, E3 and E4) expressed in Escherichia coli","volume":"35","author":"Barbier","year":"1997","journal-title":"Eur. J. Clin. Chem. Clin. Biochem."},{"key":"10.1006\/nbdi.2000.0362_RF2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0165-0173(98)00008-3","article-title":"The neurobiology of apolipoproteins and their receptors in the CNS and Alzheimer's disease","volume":"27","author":"Beffert","year":"1998","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1006\/nbdi.2000.0362_RF3","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/978-1-4684-6012-4_34","article-title":"Localization of cathepsin D in endosomes: Characterization and biological importance","volume":"306","author":"Blum","year":"1991","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1006\/nbdi.2000.0362_RF4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1172\/JCI112130","article-title":"Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system","volume":"76","author":"Boyles","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1006\/nbdi.2000.0362_RF5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1083\/jcb.130.4.781","article-title":"Role for phosphatidylinositol 3-kinase in the sorting and transport of newly synthesized lysosomal enzymes in mammalian cells","volume":"130","author":"Brown","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1006\/nbdi.2000.0362_RF6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0092-8674(92)90306-W","article-title":"The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway","volume":"70","author":"Bucci","year":"1992","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0362_RF7","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/0896-6273(95)90324-0","article-title":"Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system","volume":"14","author":"Cataldo","year":"1995","journal-title":"Neuron"},{"key":"10.1006\/nbdi.2000.0362_RF8","doi-asserted-by":"crossref","first-page":"6142","DOI":"10.1523\/JNEUROSCI.17-16-06142.1997","article-title":"Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer's disease: Neuropathologic evidence for a mechanism of increased beta-amyloidogenesis","volume":"17","author":"Cataldo","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1006\/nbdi.2000.0362_RF9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0092-8674(90)90369-P","article-title":"Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments","volume":"62","author":"Chavrier","year":"1990","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0362_RF10","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1006\/nbdi.2000.0362_RF11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/361721a0","article-title":"A sensory role for neuronal growth cone filopodia","volume":"361","author":"Davenport","year":"1993","journal-title":"Nature"},{"key":"10.1006\/nbdi.2000.0362_RF12","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1016\/S0021-9258(18)68729-0","article-title":"Cathepsin D is membrane-associated in macrophage endosomes","volume":"263","author":"Diment","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1006\/nbdi.2000.0362_RF13","doi-asserted-by":"crossref","first-page":"3303","DOI":"10.1083\/jcb.109.6.3303","article-title":"Iterative fractionation of recycling receptors from lysosomally destined ligands in an early sorting endosome","volume":"109","author":"Dunn","year":"1989","journal-title":"J. Cell Biol."},{"key":"10.1006\/nbdi.2000.0362_RF14","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1242\/dev.117.2.689","article-title":"Actin depolymerisation induces process formation on MAP2-transfected non-neuronal cells","volume":"117","author":"Edson","year":"1993","journal-title":"Development"},{"key":"10.1006\/nbdi.2000.0362_RF15","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80585-1","article-title":"Regulation of membrane trafficking: Structural insights from a Rab\/effector complex","volume":"96","author":"Gonzalez","year":"1999","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0362_RF16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0092-8674(05)80030-3","article-title":"Developmental mechanisms that generate precise patterns of neuronal connectivity","volume":"72","author":"Goodman","year":"1993","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0362_RF17","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0092-8674(91)90316-Q","article-title":"Rab5 controls early endosome fusion in vitro","volume":"64","author":"Gorvel","year":"1991","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0362_RF18","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/0955-0674(95)80013-1","article-title":"Membrane transport in the endocytic pathway","volume":"7","author":"Gruenberg","year":"1995","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1006\/nbdi.2000.0362_RF19","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1016\/S0021-9258(18)49957-7","article-title":"Interaction of free apolipoproteins with macrophages. Formation of high density lipoprotein-like lipoproteins and reduction of cellular cholesterol","volume":"266","author":"Hara","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/nbdi.2000.0362_RF20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0896-6273(94)90456-1","article-title":"The involvement of the small GTP-binding protein Rab5a in neuronal endocytosis","volume":"13","author":"de Hoop","year":"1994","journal-title":"Neuron"},{"key":"10.1006\/nbdi.2000.0362_RF21","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/346335a0","article-title":"Movement of internalized ligand-receptor complexes along a continuous endosomal reticulum","volume":"346","author":"Hopkins","year":"1990","journal-title":"Nature"},{"key":"10.1006\/nbdi.2000.0362_RF22","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.1074\/jbc.273.22.13452","article-title":"Differential cellular accumulation\/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than E4","volume":"273","author":"Ji","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/nbdi.2000.0362_RF23","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1073\/pnas.86.15.5810","article-title":"Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins","volume":"86","author":"Kowal","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/nbdi.2000.0362_RF24","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1074\/jbc.273.7.3848","article-title":"Wortmannin retards the movement of the mannose 6-phosphate\/insulin-like growth factor II receptor and its ligand out of endosomes","volume":"273","author":"Kundra","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/nbdi.2000.0362_RF25","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1083\/jcb.104.6.1743","article-title":"Lysosomal enzyme precursors in coated vesicles derived from the exocytic and endocytic pathways","volume":"104","author":"Lemansky","year":"1987","journal-title":"J. Cell Biol."},{"key":"10.1006\/nbdi.2000.0362_RF26","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1126\/science.3283935","article-title":"Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology","volume":"240","author":"Mahley","year":"1988","journal-title":"Science"},{"key":"10.1006\/nbdi.2000.0362_RF27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.cellbio.12.1.575","article-title":"Endocytosis and molecular sorting","volume":"12","author":"Mellman","year":"1996","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1006\/nbdi.2000.0362_RF28","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1016\/S0021-9258(18)49980-2","article-title":"CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells","volume":"266","author":"Metzelaar","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1006\/nbdi.2000.0362_RF29","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1046\/j.1471-4159.2000.0741008.x","article-title":"Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in culture","volume":"74","author":"Michikawa","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1006\/nbdi.2000.0362_RF30","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1152\/physrev.1997.77.3.759","volume":"77","author":"Mukherjee","year":"1997","journal-title":"Endocytosis. Physiol. Rev."},{"key":"10.1006\/nbdi.2000.0362_RF31","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1126\/science.8171342","article-title":"Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro","volume":"264","author":"Nathan","year":"1994","journal-title":"Science"},{"key":"10.1006\/nbdi.2000.0362_RF32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/0005-2760(87)90295-5","article-title":"Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins","volume":"917","author":"Pitas","year":"1987","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/nbdi.2000.0362_RF33","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/0955-0674(90)90108-Q","article-title":"Endocytosis and transcytosis","volume":"2","author":"Rodman","year":"1990","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1006\/nbdi.2000.0362_RF34","first-page":"413","article-title":"Influence of the susceptibility genes apolipoprotein E-epsilon 4 and apolipoprotein E-epsilon 2 on the rate of disease expressivity of late-onset Alzheimer's disease","volume":"45","author":"Roses","year":"1995","journal-title":"Arzneimittel-Forschung"},{"key":"10.1006\/nbdi.2000.0362_RF35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0092-8674(95)90158-2","article-title":"Making the connection\u2014Cytoskeletal rearrangements during growth cone guidance","volume":"83","author":"Tanaka","year":"1995","journal-title":"Cell"},{"key":"10.1006\/nbdi.2000.0362_RF36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.cb.09.110193.001021","article-title":"Signal-dependent membrane protein trafficking in the endocytic pathway","volume":"9","author":"Trowbridge","year":"1993","journal-title":"Annu. Rev. Cell Biol."},{"key":"10.1006\/nbdi.2000.0362_RF37","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1006\/nbdi.1997.0131","article-title":"Apolipoprotein E uptake and low-density lipoprotein receptor-related protein expression by the NTera2\/D1 cell line: A cell culture model of relevance for late-onset Alzheimer's disease","volume":"4","author":"Williams","year":"1997","journal-title":"Neurobiol. Dis."},{"key":"10.1006\/nbdi.2000.0362_RF38","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/nbdi.1998.0198","article-title":"Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons","volume":"5","author":"Williams","year":"1998","journal-title":"Neurobiol. Dis."},{"key":"10.1006\/nbdi.2000.0362_RF39","series-title":"Apolipoprotein E Uptake by Cultured Human Central Nervous System Neurons","author":"Williams","year":"1998"}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996100903620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996100903620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:07:40Z","timestamp":1620018460000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996100903620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S0969996100903620"],"URL":"https:\/\/doi.org\/10.1006\/nbdi.2000.0362","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}