{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T19:28:36Z","timestamp":1773343716004,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,2,1]],"date-time":"2001-02-01T00:00:00Z","timestamp":980985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nitric Oxide"],"published-print":{"date-parts":[[2001,2]]},"DOI":"10.1006\/niox.2000.0328","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T19:46:43Z","timestamp":1032378403000},"page":"18-31","source":"Crossref","is-referenced-by-count":75,"title":["Erythrocyte Consumption of Nitric Oxide: Competition Experiment and Model Analysis"],"prefix":"10.1006","volume":"5","author":[{"given":"Mark W.","family":"Vaughn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuang-Tse","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lih","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/niox.2000.0328_RF1","first-page":"3301","article-title":"Conformation, co-operativity and ligand binding in human hemoglobin","volume":"91","author":"Cassoly","year":"1974","journal-title":"J. Mol. Biol."},{"key":"10.1006\/niox.2000.0328_RF2","doi-asserted-by":"crossref","first-page":"6976","DOI":"10.1021\/bi960442g","article-title":"Mechanism of NO-induced oxidation of myoglobin and hemoglobin","volume":"35","author":"Eich","year":"1996","journal-title":"Biochemistry"},{"key":"10.1006\/niox.2000.0328_RF3","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1073\/pnas.91.17.8137","article-title":"Simulation of the diffusion and reaction of endogenously produced nitric oxide","volume":"91","author":"Lancaster","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/niox.2000.0328_RF4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0076-6879(96)68007-0","article-title":"Diffusion of free nitric oxide","volume":"268","author":"Lancaster","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1006\/niox.2000.0328_RF5","doi-asserted-by":"crossref","first-page":"H1705","DOI":"10.1152\/ajpheart.1998.274.5.H1705","article-title":"Effective diffusion distance of nitric oxide in the microcirculation","volume":"274","author":"Vaughn","year":"1998","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1006\/niox.2000.0328_RF6","doi-asserted-by":"crossref","first-page":"8757","DOI":"10.1073\/pnas.96.15.8757","article-title":"Intravascular flow decreases erythrocyte consumption of nitric oxide","volume":"96","author":"Liao","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/niox.2000.0328_RF7","first-page":"97","article-title":"Impaired tissue perfusion after inhibition of endothelium-derived nitric oxide","volume":"86","author":"Pohl","year":"1991","journal-title":"Basic Res. Cardiol."},{"key":"10.1006\/niox.2000.0328_RF8","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1152\/jappl.1994.77.5.2348","article-title":"Stroma-free hemoglobin increases blood pressure and GFR in the hypotensive rat: Role of nitric oxide","volume":"77","author":"Thompson","year":"1994","journal-title":"J. Appl. Physiol."},{"key":"10.1006\/niox.2000.0328_RF9","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nbt0798-672","article-title":"Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin","volume":"16","author":"Doherty","year":"1998","journal-title":"Nature Biotech."},{"key":"10.1006\/niox.2000.0328_RF10","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0304-4165(98)00065-8","article-title":"Diffusion of nitric oxide and scavenging by blood in the vasculature","volume":"1425","author":"Butler","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/niox.2000.0328_RF11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0006-3495(80)85118-6","article-title":"Hydrodynamic and diffusion considerations of rapid-mix experiments with red blood cells","volume":"29","author":"Rice","year":"1980","journal-title":"Biophys. J."},{"key":"10.1006\/niox.2000.0328_RF12","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/S0021-9258(17)34185-6","article-title":"The rate of oxygen uptake by human red blood cells","volume":"254","author":"Coin","year":"1979","journal-title":"J. Biol. Chem."},{"key":"10.1006\/niox.2000.0328_RF13","doi-asserted-by":"crossref","first-page":"12619","DOI":"10.1016\/S0021-9258(18)90791-X","article-title":"Morphological and physiological factors affecting oxygen uptake and release by red blood cells","volume":"259","author":"Vandegriff","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1006\/niox.2000.0328_RF14","doi-asserted-by":"crossref","first-page":"18709","DOI":"10.1074\/jbc.273.30.18709","article-title":"Diffusion-limited reaction of free nitric oxide with erythrocytes","volume":"273","author":"Liu","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1006\/niox.2000.0328_RF15","doi-asserted-by":"crossref","first-page":"2342","DOI":"10.1074\/jbc.275.4.2342","article-title":"Erythrocytes possess an intrinsic barrier to nitric oxide consumption","volume":"275","author":"Vaughn","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1006\/niox.2000.0328_RF16","series-title":"Grune & Stratton","article-title":"Red Cell Metabolism: A Manual of Biochemical Methods","author":"Beutler","year":"1984"},{"key":"10.1006\/niox.2000.0328_RF17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0076-6879(81)76111-1","article-title":"Preparation of blood hemoglobins of vertebrates","volume":"76","author":"Riggs","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1006\/niox.2000.0328_RF18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0076-6879(96)68030-6","article-title":"\u201cNONOates\u201d (1-substituted diazen-1-ium-1,2-diolates) as nitric oxide donors: Convenient nitric oxide dosage forms","volume":"268","author":"Keefer","year":"1996","journal-title":"Methods Enzymol."},{"key":"10.1006\/niox.2000.0328_RF19","series-title":"Transport Phenomena and Living Systems","author":"Lightfoot","year":"1974"},{"key":"10.1006\/niox.2000.0328_RF20","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1006\/abbi.1996.0162","article-title":"Nitric oxide diffusion in membranes determined by fluorescence quenching","volume":"328","author":"Denicola","year":"1996","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1006\/niox.2000.0328_RF21","doi-asserted-by":"crossref","first-page":"343","DOI":"10.3109\/10715769609088032","article-title":"Permeability of nitric oxide through lipid bilayer membranes","volume":"24","author":"Subczynski","year":"1996","journal-title":"Free Rad. Res."},{"key":"10.1006\/niox.2000.0328_RF22","doi-asserted-by":"crossref","first-page":"11460","DOI":"10.1073\/pnas.93.21.11460","article-title":"Whole body nitric oxide synthesis in healthy men determined from [15N]arginine-to-[15N]citrulline labeling","volume":"93","author":"Castillo","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/niox.2000.0328_RF23","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/380221a0","article-title":"S-nitrosolhaemoglobin: A dynamic activity of blood involved in vascular control","volume":"380","author":"Jia","year":"1996","journal-title":"Nature"},{"key":"10.1006\/niox.2000.0328_RF24","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1073\/pnas.95.5.2175","article-title":"Accelerated reaction of nitric oxide with o2 within the hydrophobic interior of biological membranes","volume":"95","author":"Liu","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/niox.2000.0328_RF25","series-title":"Low Reynolds Number Hydrodynamics, 2nd ed.","author":"Happel","year":"1973"},{"key":"10.1006\/niox.2000.0328_RF26","series-title":"Comprehensive Human Physiology","first-page":"2427","article-title":"Normal values for physiological parameters","author":"Greger","year":"1996"},{"key":"10.1006\/niox.2000.0328_RF27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rspb.1932.0041","article-title":"Diffusion and chemical reaction velocity as joint factors in determining the rate of uptake of oxygen and carbon monoxide by red blood corpuscles","volume":"111","author":"Roughton","year":"1932","journal-title":"Proc. R. Soc. London B Biol. Sci."},{"key":"10.1006\/niox.2000.0328_RF28","series-title":"Momentum, Energy, and Mass Transfer in Continua, 2nd ed.","author":"Slattery","year":"1981"},{"key":"10.1006\/niox.2000.0328_RF29","series-title":"Numerical Recipes in C, 2nd ed.","author":"Press","year":"1992"},{"key":"10.1006\/niox.2000.0328_RF30","doi-asserted-by":"crossref","first-page":"H2163","DOI":"10.1152\/ajpheart.1998.274.6.H2163","article-title":"Estimation of nitric oxide production and reaction rates in tissue using a mathematical model","volume":"274","author":"Vaughn","year":"1998","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Nitric Oxide"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860300903288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1089860300903288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T05:06:51Z","timestamp":1620018411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1089860300903288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,2]]}},"alternative-id":["S1089860300903288"],"URL":"https:\/\/doi.org\/10.1006\/niox.2000.0328","relation":{},"ISSN":["1089-8603"],"issn-type":[{"value":"1089-8603","type":"print"}],"subject":[],"published":{"date-parts":[[2001,2]]}}}