{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:20:43Z","timestamp":1773242443636,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2000,1]]},"DOI":"10.1006\/phrs.1999.0547","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T20:00:15Z","timestamp":1033934415000},"page":"1-7","source":"Crossref","is-referenced-by-count":12,"title":["EFFECTS OF LOCAL ANAESTHETICS ON THE ACTIVITY OF THE Na,K-ATPASE OF CANINE RENAL MEDULLA"],"prefix":"10.1006","volume":"41","author":[{"given":"HOWARD","family":"KUTCHAI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"LISA M.","family":"GEDDIS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT A.","family":"FARLEY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/phrs.1999.0547_PHRS.RF1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1042\/bj2390301","article-title":"Charged anesthetics alter LM-fibroblast plasma membrane enzymes by selective fluidization of inner or outer membrane leaflets","volume":"239","author":"Sweet","year":"1986","journal-title":"Biochem J"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/0304-4165(84)90208-3","article-title":"Inhibition of synaptosomal enzymes by local anesthetics","volume":"801","author":"Sidek","year":"1984","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF3","first-page":"308","article-title":"The effect of methylxanthines and local anesthetics on fragmented sarcoplasmic reticulum","volume":"169","author":"Johnson","year":"1969","journal-title":"J Pharm Exp Ther"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF4","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/0005-2787(76)90518-9","article-title":"Aspects of the mechanism of action of local anesthetics on the sarcoplasmic reticulum","volume":"443","author":"Suko","year":"1976","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF5","doi-asserted-by":"crossref","first-page":"13208","DOI":"10.1021\/bi00249a007","article-title":"Hexanol and lidocaine affect the oligomeric state of the Ca-ATPase of sarcoplasmic reticulum","volume":"33","author":"Kutchai","year":"1994","journal-title":"Biochemistry"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF6","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1093\/cvr\/9.6.764","article-title":"Effects of local anesthetics on calcium transport by canine cardiac microsomes","volume":"9","author":"Katz","year":"1975","journal-title":"Cardiovasc Res"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF7","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S0006-3495(95)80269-9","article-title":"Anesthetics alter the physical and functional properties of the Ca-ATPase in cardiac sarcoplasmic reticulum","volume":"68","author":"Karon","year":"1995","journal-title":"Biophys J"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF8","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1111\/j.1471-4159.1990.tb01954.x","article-title":"Modulation of the Ca2+,Mg2+-ATPase activity of synaptosomal membrane by the local anesthetics dibucaine and lidocaine","volume":"54","author":"Garcia-Martin","year":"1990","journal-title":"J Neurochem"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF9","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1471-4159.1990.tb04147.x","article-title":"Modulation of calcium fluxes across synaptosomal plasma membrane by local anesthetics","volume":"55","author":"Garcia-Martin","year":"1990","journal-title":"J Neurochem"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF10","first-page":"36","article-title":"Purification and characterization of (Na++K+)-ATPase","volume":"356","author":"Jorgensen","year":"1974","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF11","series-title":"A flexible system of enzymatic analysis.","author":"Lowry","year":"1972"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF12","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1085\/jgp.82.6.725","article-title":"Kinetics of Na,K-ATPase activity by the Na,K-pump","volume":"82","author":"N\u00f8rby","year":"1983","journal-title":"J Gen Physiol"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF13","doi-asserted-by":"crossref","first-page":"13937","DOI":"10.1074\/jbc.270.23.13937","article-title":"The influence of \u03b2 subunit structure on the interaction of Na+\/K+-ATPase with Na+","volume":"270","author":"Eakle","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF14","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/phrs.1999.0541","article-title":"Effects of general anesthetics on the activity of the Na,K-ATPase of canine renal medulla","volume":"40","author":"Kutchai","year":"1999","journal-title":"Pharmacol Res"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF15","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/bi9722002","article-title":"Differential effects of gene ral anesthetics on the quaternary structure of the Ca-ATPases of cardiac and skeletal sarcoplasmic reticulum","volume":"37","author":"Kutchai","year":"1998","journal-title":"Biochemistry"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF16","first-page":"114","article-title":"Structure-activity relations for frequency-dependent sodium channel block in nerve by local anesthetics","volume":"213","author":"Courtney","year":"1980","journal-title":"J Pharm Exp Ther"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1085\/jgp.69.4.475","article-title":"The pH-dependent action of local anesthetics on the node of Ranvier","volume":"69","author":"Hille","year":"1977","journal-title":"J Gen Physiol"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1085\/jgp.62.1.37","article-title":"The inhibition of sodium currents in myelinated nerve by quaternary derivatives of lidocaine","volume":"62","author":"Strichartz","year":"1973","journal-title":"J Gen Physiol"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF19","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1213\/00000539-199008000-00008","article-title":"Fundamental properties of local anesthetics. II. Measured octanol\/buffer partition coefficients and pKa values for clinically used drugs","volume":"71","author":"Strichartz","year":"1990","journal-title":"Anesth Analg"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jps.2600610102","article-title":"Linear relationships between lipophilic character and biological activity of drugs","volume":"61","author":"Hansch","year":"1972","journal-title":"J Pharm Sci"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF21","first-page":"325","article-title":"Local anesthetics","volume":"10","author":"Skou","year":"1954","journal-title":"Acta Pharmacol Toxicol"},{"key":"10.1006\/phrs.1999.0547_PHRS.RF22","series-title":"Local anesthetics.","first-page":"53","article-title":"Structural elements which determine local anesthetic activity","author":"Courtney","year":"1987"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661899905479?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661899905479?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T06:42:33Z","timestamp":1576564953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661899905479"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["S1043661899905479"],"URL":"https:\/\/doi.org\/10.1006\/phrs.1999.0547","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}