{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:57:27Z","timestamp":1773143847298,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1006\/phrs.1999.0648","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T20:38:41Z","timestamp":1032381521000},"page":"75-80","source":"Crossref","is-referenced-by-count":75,"title":["MECHANISMS FOR THE HEPATOPROTECTIVE ACTION OF KOLAVIRON: STUDIES ON HEPATIC ENZYMES, MICROSOMAL LIPIDS AND LIPID PEROXIDATION IN CARBONTETRACHLORIDE-TREATED RATS"],"prefix":"10.1006","volume":"42","author":[{"given":"E.","family":"OLATUNDE FAROMBI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/phrs.1999.0648_RF1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2220001","article-title":"Free radical mechanisms in tissue injury","volume":"222","author":"Slater","year":"1984","journal-title":"Biochem J"},{"key":"10.1006\/phrs.1999.0648_RF2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/13510002.1996.11747026","article-title":"Tryptophan reaction with free radicals arisen from carbon tetrachloride in a model system","volume":"2","author":"Castro","year":"1996","journal-title":"Redox Rep"},{"key":"10.1006\/phrs.1999.0648_RF3","series-title":"Plants used in native medicine in Nigeria","author":"Ainslie","year":"1937"},{"key":"10.1006\/phrs.1999.0648_RF4","series-title":"Traditional Igbo medicine","author":"Iwu","year":"1982"},{"key":"10.1006\/phrs.1999.0648_RF5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.2042-7158.1990.tb05412.x","article-title":"Antidiabetic and aldose reductase activities of biflavanones of Garcinia kola","volume":"42","author":"Iwu","year":"1990","journal-title":"J Pharm Pharmacol"},{"key":"10.1006\/phrs.1999.0648_RF6","unstructured":"Geiger, H, Quine, C, Biflavanoids, The flavonoids\u2014 advances since 1980, Harbone, J, B, London: Chapman and Hall, 1988: 99, 124"},{"key":"10.1006\/phrs.1999.0648_RF7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0305-1978(83)90025-X","article-title":"Systematic significance of xanthones, benzop henones and biflavonoids in Garcinia","volume":"11","author":"Waterman","year":"1983","journal-title":"Biochem Syst Ecol"},{"key":"10.1006\/phrs.1999.0648_RF8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/BF02007729","article-title":"Antihepatotoxic, constituents of Garcina kola seeds","volume":"41","author":"Iwu","year":"1985","journal-title":"Experientia"},{"key":"10.1006\/phrs.1999.0648_RF9","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0378-8741(87)90123-1","article-title":"Evaluation of the antihepatotoxic activity of the biflavanoids of Garcinia kola seeds","volume":"21","author":"Iwu","year":"1987","journal-title":"J Ethnopharmacol"},{"key":"10.1006\/phrs.1999.0648_RF10","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0378-8741(90)90057-Z","article-title":"Protective effects of Garcinia kola seed extract against paracetamol- induced hepatotoxicity in rats","volume":"29","author":"Akintonwa","year":"1990","journal-title":"J Ethnopharmacol"},{"key":"10.1006\/phrs.1999.0648_RF11","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ptr.2650040407","article-title":"Prevention of thioacetamide-induced hepa toxicity by biflavanones of Garcinia kola","volume":"4","author":"Iwu","year":"1990","journal-title":"Phytother Res"},{"key":"10.1006\/phrs.1999.0648_RF12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/ptr.2650050111","article-title":"Inhibition of drug metabolism by flavonoid extract (kolaviron) of Garcinia kola seeds in the rat","volume":"5","author":"Braide","year":"1991","journal-title":"Phytother Res"},{"key":"10.1006\/phrs.1999.0648_RF13","unstructured":"Schenkman, J, B, Remmer, H, Estabrook, R, W, Spectral studies of drug interaction with hepatic microsomal cytochrome, Molec Phamacol, 3, 113, 23"},{"key":"10.1006\/phrs.1999.0648_RF14","doi-asserted-by":"crossref","unstructured":"La Du, B, N, Gaudette, L, Trousof, N, Brodie, B, B, Enzymatic dealkylation of aminopyrine and other alkylamines, J Biol Chem, 214, 741, 51","DOI":"10.1016\/S0021-9258(18)70923-X"},{"key":"10.1006\/phrs.1999.0648_RF15","doi-asserted-by":"crossref","unstructured":"Nash, T, The colorimetric estimation of formaldehyde by means of the Hantzech reaction, Biochem J, 55, 416, 26","DOI":"10.1042\/bj0550416"},{"key":"10.1006\/phrs.1999.0648_RF16","doi-asserted-by":"crossref","unstructured":"Guo, Z, Smith, T, J, Wang, E, Sadrieh, N, Ma, Q, Thomas, P, E, Yang, C, S, Effects of phenethyl isothiocyanate, a carcinogenesis inhibitor, on xenobiotic-metabolizing enzymes and nitrosamine metabolism in rats, Carcinogenesis, 13, 2205, 10","DOI":"10.1093\/carcin\/13.12.2205"},{"key":"10.1006\/phrs.1999.0648_RF17","series-title":"Introduction to drug metabolism","author":"Gibson","year":"1994"},{"key":"10.1006\/phrs.1999.0648_RF18","doi-asserted-by":"crossref","unstructured":"Isselbacher, K, J, Chrabas, M, F, Quinn, R, C, The solubilization and partial purification of glucuronyl transferase from rabbit liver microsomes, J Biol Chest, 237, 3033, 6","DOI":"10.1016\/S0021-9258(18)50116-2"},{"key":"10.1006\/phrs.1999.0648_RF19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0006-3002(62)90048-3","article-title":"Alteration in tissue levels of UDP-glucose dehydrogenase, UDP-glucuronic acid pyrophosphatase and glucuronyl transferase induced by substances influencing the production of ascorbic acid","volume":"62","author":"Hollman","year":"1962","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/phrs.1999.0648_RF20","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"Glutathione- S -transferase","volume":"249","author":"Habig","year":"1974","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0648_RF21","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1093\/clinchem\/15.8.727","article-title":"A simplified procedure for the assay of 5\u2032nucleotidase","volume":"15","author":"Rieder","year":"1969","journal-title":"Clin Chem"},{"key":"10.1006\/phrs.1999.0648_RF22","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0009-8981(59)90165-2","article-title":"The pathological occurrence of glucose-6-phosphatase in serum in liver diseases","volume":"4","author":"Koide","year":"1959","journal-title":"Clin Chim Acta"},{"key":"10.1006\/phrs.1999.0648_RF23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0021-9258(18)64849-5","article-title":"A simple method for the isolation and purification of total lipids from animal tissue","author":"Folch","year":"1957","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0648_RF24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)84756-1","article-title":"The colorimetric determination of phosphorus","volume":"66","author":"Fiske","year":"1925","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0648_RF25","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0021-9258(18)70226-3","article-title":"Phosphorus assay in column chromatography","volume":"234","author":"Barlett","year":"1959","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0648_RF26","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0022-2275(20)36896-6","article-title":"Determination of cholesterol using O -phthaldehyde","volume":"14","author":"Rudel","year":"1973","journal-title":"J Lipid Res"},{"key":"10.1006\/phrs.1999.0648_RF27","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S0076-6879(78)52032-6","article-title":"Microsomal lipid peroxidation","volume":"52","author":"Buege","year":"1978","journal-title":"Method Enzymol"},{"key":"10.1006\/phrs.1999.0648_RF28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0648_RF29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/ptr.2650050110","article-title":"Antihepatotoxic biochemical effects of kolaviron, a biflavonoid of Garcinia kola seeds","volume":"5","author":"Braide","year":"1991","journal-title":"Phytother Res"},{"key":"10.1006\/phrs.1999.0648_RF30","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/0006-2952(90)90625-U","article-title":"Mechanism for the protective effects of silymarin against carbon tetrachloride-induced lipid peroxidation and hepatotoxicity in mice","volume":"39","author":"Letteron","year":"1990","journal-title":"Biochem Pharmacol"},{"key":"10.1006\/phrs.1999.0648_RF31","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1016\/0006-2952(95)00083-C","article-title":"Effect of Eugenol on drug-metabolizing enzymes of carbon tetrachloride-intoxicated rat liver","volume":"49","author":"Kumaravelu","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"10.1006\/phrs.1999.0648_RF32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/00498257709035798","article-title":"Metabolic activation of haloalkanes and tests in vitro for mutagenicity","volume":"7","author":"Uehleke","year":"1977","journal-title":"Xenobiotica"},{"key":"10.1006\/phrs.1999.0648_RF33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF00315600","article-title":"Formation of chloroform from carbontetrachloride in liver microsomes, lipid peroxidation and destruction of cytochrome P-450","volume":"29","author":"Reiner","year":"1972","journal-title":"Arch Toxicol"},{"key":"10.1006\/phrs.1999.0648_RF34","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/0003-9861(73)90580-8","article-title":"Lipid peroxidation and the degradation of cytochrome P-450 heme","volume":"158","author":"Levine","year":"1973","journal-title":"Arch Biochem Biophys"},{"key":"10.1006\/phrs.1999.0648_RF35","doi-asserted-by":"crossref","first-page":"3714","DOI":"10.1016\/S0021-9258(18)83427-5","article-title":"Resolution of the cytochrome P-450 containing co-hydroxylation system of liver microsomes into three components","volume":"244","author":"Lu","year":"1969","journal-title":"J Biol Chem"},{"key":"10.1006\/phrs.1999.0648_RF36","doi-asserted-by":"crossref","first-page":"3005","DOI":"10.1016\/0006-2952(83)90241-1","article-title":"Changes in some rat hepatic microsomal components induced by prolonged administration of chloroquine","volume":"32","author":"Emerole","year":"1983","journal-title":"Biochem Pharmacol"},{"key":"10.1006\/phrs.1999.0648_RF37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0955-2863(95)00152-2","article-title":"Dietary influences on membrane function: importance in protection against damage and disease","volume":"7","author":"Wiseman","year":"1995","journal-title":"J Nutr Biochem"},{"key":"10.1006\/phrs.1999.0648_RF38","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/0005-2760(80)90141-1","article-title":"Lipid peroxidation of rat liver microsomes","volume":"620","author":"Koster","year":"1980","journal-title":"Biochim Biophys Acta"},{"key":"10.1006\/phrs.1999.0648_RF39","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1006\/abbi.1994.1393","article-title":"Oxygen radical-induced in hibition of alkaline phosphatase activity in reconstituted membranes","volume":"313","author":"Ohyashiki","year":"1994","journal-title":"Arch Biochem Blophys"},{"key":"10.1006\/phrs.1999.0648_RF40","first-page":"5856","article-title":"Regulati on of uridine diphosphate glucuronosyltransferase expression by phenolic antioxidants","volume":"54","author":"Kashfi","year":"1994","journal-title":"Cancer Res"},{"key":"10.1006\/phrs.1999.0648_RF41","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1093\/carcin\/13.12.2255","article-title":"Modulation of glutathione S - transferases and glutathionc peroxidase by the anticarcinogen butylated hydroxyanisole in murine extrahepatic organs","volume":"13","author":"McLellan","year":"1992","journal-title":"Carcinogenesis"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661899906485?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661899906485?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T02:05:20Z","timestamp":1620007520000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661899906485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S1043661899906485"],"URL":"https:\/\/doi.org\/10.1006\/phrs.1999.0648","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}