{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T08:41:29Z","timestamp":1771058489481,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2001,5,1]],"date-time":"2001-05-01T00:00:00Z","timestamp":988675200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2001,5]]},"DOI":"10.1006\/phrs.2001.0801","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T20:38:41Z","timestamp":1032381521000},"page":"463-467","source":"Crossref","is-referenced-by-count":57,"title":["Protective role of nitric oxide in indomethacin-induced gastric ulceration by a mechanism independent of gastric acid secretion"],"prefix":"10.1006","volume":"43","author":[{"given":"Mahmoud M.","family":"Khattab","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Z.","family":"Gad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalaal","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/phrs.2001.0801_RF1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1007\/BF02087540","article-title":"Effects of misoprostol on delayed ulcer healing induced by aspirin","volume":"39","author":"Penny","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1006\/phrs.2001.0801_RF2","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.91.8.3228","article-title":"Selective inhibition of inducible cyclooxygenase 2 in vivo is anti-inflammatory and nonulcerogenic","volume":"91","author":"Masferrer","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/phrs.2001.0801_RF3","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0016-5085(94)90074-4","article-title":"Novel nonsteroidal anti-inflammatory drug derivatives with markedly reduced ulcerogenic properties in the rat","volume":"107","author":"Wallace","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1006\/phrs.2001.0801_RF4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.1476-5381.1993.tb13442.x","article-title":"The actions of nitric oxide donors in the prevention or induction of injury to the rat gastric mucosa","volume":"108","author":"Lopez-Belmonte","year":"1993","journal-title":"Br J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF5","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/BF02090210","article-title":"Protection against ischemia-reperfusion injury by nitric oxide generators","volume":"39","author":"Andrews","year":"1994","journal-title":"Dig Dis Sci"},{"key":"10.1006\/phrs.2001.0801_RF6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/sj.bjp.0702649","article-title":"Mechanisms of gastroprotection by transdermal nitroglycerin in the rat","volume":"127","author":"Calatayud","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF7","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1159\/000201419","article-title":"Role of nitric oxide in mucosal blood flow response and the healing of HCl-induced lesions in the rat stomach","volume":"58","author":"Takeuchi","year":"1997","journal-title":"Digestion"},{"key":"10.1006\/phrs.2001.0801_RF8","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000007506","article-title":"Role of nitric oxide in pathogenesis of aspirin-induced gastric mucosal damage in rats","volume":"59","author":"Takeuchi","year":"1998","journal-title":"Digestion"},{"key":"10.1006\/phrs.2001.0801_RF9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S0016-5085(54)80008-4","article-title":"A quantitative method for measuring spontaneous gastric secretion in the rat","volume":"26","author":"Shay","year":"1954","journal-title":"Gastroenterology"},{"key":"10.1006\/phrs.2001.0801_RF10","first-page":"1","article-title":"Physiology for physician","volume":"1","author":"Grossman","year":"1963","journal-title":"A Monthly Publication of the American Physiological Society"},{"key":"10.1006\/phrs.2001.0801_RF11","series-title":"Peptic ulcer","first-page":"312","article-title":"The effect of cyproheptadine on gastric acidity","author":"Sanyal","year":"1971"},{"key":"10.1006\/phrs.2001.0801_RF12","series-title":"Methods of biochemical analysis","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110188.ch10","article-title":"Determination of serum glycoproteins","author":"Winzler","year":"1955"},{"key":"10.1006\/phrs.2001.0801_RF13","first-page":"657","article-title":"Gastric anti-secretory, anti-ulcer and cytoprotective properties of 9-hydroxy-19,20-bis-nor-prostanoic acid in experimental animals","volume":"32","author":"Valcavi","year":"1982","journal-title":"Arzneimittel Forschung"},{"key":"10.1006\/phrs.2001.0801_RF14","doi-asserted-by":"crossref","first-page":"9265","DOI":"10.1073\/pnas.84.24.9265","article-title":"Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide","volume":"84","author":"Ignarro","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/phrs.2001.0801_RF15","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0014-2999(89)90324-5","article-title":"The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation","volume":"174","author":"Pique","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF16","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0016-5085(92)91797-8","article-title":"Endogenous nitric oxide as a mediator of gastric mucosal vasodilataion during acid secretion","volume":"102","author":"Pique","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1006\/phrs.2001.0801_RF17","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1073\/pnas.88.11.4651","article-title":"Nitric oxide: an endogenous modulator of leukocyte adhesion","volume":"88","author":"Kubes","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/phrs.2001.0801_RF18","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/sj.bjp.0702649","article-title":"Mechanisms of gastroprotection by transdermal nitroglycerin in the rat","volume":"127","author":"Calatayud","year":"1999","journal-title":"Br J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF19","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1053\/gast.1997.v112.pm9041264","article-title":"Non-steroidal anti-inflammatory drugs and gastropathy: the second hundred years","volume":"112","author":"Wallace","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1006\/phrs.2001.0801_RF20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0014-2999(93)90997-V","article-title":"Inhibition of nitric oxide synthetase delays healing of chronic gastric ulcers","volume":"239","author":"Konturek","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF21","first-page":"A700","article-title":"The selective beneficial effects of nitric oxide inhibition in experimental colitis","volume":"106","author":"Hogaboam","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1006\/phrs.2001.0801_RF22","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1073\/pnas.90.15.7240","article-title":"Nitric oxide activates cyclooxygenase enzymes","volume":"90","author":"Salvemini","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/phrs.2001.0801_RF23","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/sj.bjp.0701745","article-title":"Effect of some cyclooxygenase inhibitors on the increase in guanosine 3\u2019:5\u2019-cyclic monophosphate induced by NO-donors in human whole platelets","volume":"123","author":"Failli","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF24","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/sj.bjp.0701691","article-title":"Role of nitric oxide in regulation of gastric acid secretion in rats: effects of NO donors and NO synthase inhibitors","volume":"123","author":"Kato","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF25","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0014-2999(92)90191-6","article-title":"The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion","volume":"218","author":"Martinez-Cuesta","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/phrs.2001.0801_RF26","first-page":"63","article-title":"Endogenous nitric oxide in the regulation of gastric acid secretion, gastric release and blood flow","volume":"15","author":"Bilski","year":"1994","journal-title":"Biomed Res"},{"key":"10.1006\/phrs.2001.0801_RF27","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/0016-5085(95)90341-0","article-title":"A nitric oxide-releasing nonsteroidal anti-inflammatory drug accelerates gastric ulcer healing in rats","volume":"109","author":"Elliot","year":"1995","journal-title":"Gastroenterology"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661801908011?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661801908011?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T00:48:35Z","timestamp":1576543715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661801908011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001,5]]}},"alternative-id":["S1043661801908011"],"URL":"https:\/\/doi.org\/10.1006\/phrs.2001.0801","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}