{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T09:19:30Z","timestamp":1781774370506,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,7,1]],"date-time":"2001-07-01T00:00:00Z","timestamp":993945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacological Research"],"published-print":{"date-parts":[[2001,7]]},"DOI":"10.1006\/phrs.2001.0826","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T20:38:41Z","timestamp":1032381521000},"page":"33-39","source":"Crossref","is-referenced-by-count":25,"title":["The role of enzyme induction and inhibition on cypermethrin hepatotoxicity"],"prefix":"10.1006","volume":"44","author":[{"given":"Osama S.","family":"El-tawil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed S.","family":"Abdel-rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/phrs.2001.0826_RF1","first-page":"715","article-title":"Inhibition of Mg2+and Na+- K+ATPase in selected tissues of fish, cyprinus carpio under fenvalerate toxicity","volume":"23","author":"Malla Reddy","year":"1991","journal-title":"Biochem Int"},{"key":"10.1006\/phrs.2001.0826_RF2","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0048-3575(88)90102-2","article-title":"Induction of hepatic mixed function oxidases by permethrin and cypermethrin in chicks fed vitamin-A-deficient diet","volume":"32","author":"Kapoor","year":"1988","journal-title":"Pestic Biochem Physiol"},{"key":"10.1006\/phrs.2001.0826_RF3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0378-4274(88)90058-6","article-title":"Genotoxic effects of a synthetic pyrethroid insecticide, cypermethrin, in mice in vivo","volume":"41","author":"Bhunya","year":"1988","journal-title":"Toxicol Lett"},{"key":"10.1006\/phrs.2001.0826_RF4","first-page":"331","article-title":"Toxicity of cypermethrin in mice, rats and rabbits","volume":"11","author":"Gupta","year":"1990","journal-title":"J Environ Biol"},{"key":"10.1006\/phrs.2001.0826_RF6","series-title":"Handbook of pesticide toxicology","author":"Hayes","year":"1991"},{"key":"10.1006\/phrs.2001.0826_RF7","series-title":"Farm chemicals hand book","author":"Meister","year":"1992"},{"key":"10.1006\/phrs.2001.0826_RF8","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1006\/taap.1994.1078","article-title":"Cocaine toxicity in cultured chicken hepatocytes: role of cytochrome P450","volume":"125","author":"LeDuc","year":"1994","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1006\/phrs.2001.0826_RF9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3109\/00498259309057024","article-title":"Rat hepatocyte-mediated metabolism of the experimental anti-tumor agent N-[2\u2019-(dimethylamino)ethyl]acridine-4-carboxamide","volume":"13","author":"Schlemper","year":"1993","journal-title":"Xenobiotica"},{"key":"10.1006\/phrs.2001.0826_RF10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1002\/jbt.2570030107","article-title":"Effects of six months feeding of cypermethrin on the blood and liver of albino rats","volume":"3","author":"Shakoori","year":"1988","journal-title":"J Biochem Toxicol"},{"key":"10.1006\/phrs.2001.0826_RF11","first-page":"493","article-title":"Clinicopathology of acute cypermethrin toxicity in goats","volume":"16","author":"Tamang","year":"1991","journal-title":"Indian J Anim Sci"},{"key":"10.1006\/phrs.2001.0826_RF12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0378-4274(98)00013-7","article-title":"Cypermethrin increases apo A-1 and apo B mRNA but not hyperlipidemia in rats","volume":"16, 1995","author":"Aldana","year":"1998","journal-title":"Toxicol Lett"},{"key":"10.1006\/phrs.2001.0826_RF13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1080\/00984109708984076","article-title":"Effect of cypermethrin on isolated male and female rat hepatocytes","volume":"52","author":"El-Tawil","year":"1997","journal-title":"J Toxicol Environ Health"},{"key":"10.1006\/phrs.2001.0826_RF14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0300-483X(86)90175-7","article-title":"Effect of pretreatment with cimetidine or phenobarbital on lipoperoxidation in carbon tetrachloride and trichloroethylene-dosed rats","volume":"39","author":"Cluet","year":"1986","journal-title":"Toxicology"},{"key":"10.1006\/phrs.2001.0826_RF15","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1083\/jcb.43.3.506","article-title":"High yield preparation of isolated rat liver parenchymal cells","volume":"43","author":"Berry","year":"1969","journal-title":"J Cell Biol"},{"key":"10.1006\/phrs.2001.0826_RF16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/(SICI)1099-1263(199703)17:2<105::AID-JAT413>3.0.CO;2-S","article-title":"The role of ethanol exposure on cocaine metabolism in rat hepatocytes","volume":"17","author":"Figliomeni","year":"1997","journal-title":"J Appl Toxicol"},{"key":"10.1006\/phrs.2001.0826_RF17","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1515\/bchm2.1975.356.s1.827","article-title":"Criteria of viability of isolated liver cells","volume":"356","author":"Baur","year":"1985","journal-title":"Hoppe-Seyler\u2019s Z Physiol Chem"},{"key":"10.1006\/phrs.2001.0826_RF18","first-page":"2411","article-title":"Cytototoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes : the role of cytochrome P450","volume":"54","author":"Goeptar","year":"1994","journal-title":"Cancer Res"},{"key":"10.1006\/phrs.2001.0826_RF19","series-title":"Methods in enzymology","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0076-6879(78)52006-5","article-title":"Isolation and use of liver cells","author":"Moldeus","year":"1978"},{"key":"10.1006\/phrs.2001.0826_RF20","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1080\/15287398309530362","article-title":"Response of isolated hepatocytes to organic and inorganic cytotoxins","volume":"11","author":"Story","year":"1983","journal-title":"J Toxicol Environ Health"},{"key":"10.1006\/phrs.2001.0826_RF21","doi-asserted-by":"crossref","first-page":"345","DOI":"10.7326\/0003-4819-43-2-345","article-title":"Serum glutamic oxalocetic transaminases activity as an indicator of liver injury; a preliminary report","volume":"43","author":"Wroblewski","year":"1955","journal-title":"Ann Intern Med"},{"key":"10.1006\/phrs.2001.0826_RF22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.3181\/00379727-91-22330","article-title":"Serum glutamic pyruvic transaminases in cardiac and hepatic diseases","volume":"91","author":"Wroblewski","year":"1956","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1006\/phrs.2001.0826_RF23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/15287398709530971","article-title":"Freshly prepared rat hepatocytes used in screening of the toxicity of blue-green algal blooms","volume":"20","author":"Berg","year":"1987","journal-title":"J Toxicol Environ Health"},{"key":"10.1006\/phrs.2001.0826_RF24","series-title":"Drug metabolism and drug toxicity","first-page":"71","author":"Smith","year":"1984"},{"key":"10.1006\/phrs.2001.0826_RF25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-642-66896-8_1","article-title":"An investigation into the value of some clinical biochemical tests in the detection of minimal changes in liver morphology and function in the rat","volume":"1 (Suppl.)","author":"Clampitt","year":"1978","journal-title":"Arch Toxicol"},{"key":"10.1006\/phrs.2001.0826_RF26","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1093\/carcin\/14.12.2531","article-title":"Enhancement of altered hepatic foci in rat liver and inhibition of intercellular communication in vitro by the pyrethroid insecticides fenvalerate, flucythrinate and cypermethrin","volume":"14","author":"Hemming","year":"1993","journal-title":"Carcinogensis"},{"key":"10.1006\/phrs.2001.0826_RF27","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0048-3575(77)90043-8","article-title":"Effects of pyrethroid structure on rates of hydrolysis and oxidation by mouse liver microsomal enzymes","volume":"7","author":"Soderlund","year":"1977","journal-title":"Pestic Biochem Physiol"},{"key":"10.1006\/phrs.2001.0826_RF28","first-page":"182","article-title":"Comparative metabolism of pyrethroids derived from 3-phenoxybenzyl and alpha-cyano-3-phenoxybenzyl alcohols","volume":"2","author":"Casida","year":"1979","journal-title":"Adv Pestic Sci"},{"key":"10.1006\/phrs.2001.0826_RF29","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.pa.23.040183.002213","article-title":"Mechanisms of selective action of pyrethroid insecticides","volume":"23","author":"Casida","year":"1983","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1006\/phrs.2001.0826_RF30","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/ps.2780080602","article-title":"The metabolism of the pyrethroid insecticide(\u00b1)- cyano-3-phenoxybenzyle2,2,3,3, tetramethylcy- clopropane carboxylate, WL 41706, in the rat","volume":"8","author":"Crawford","year":"1977","journal-title":"Pestic Sci"},{"key":"10.1006\/phrs.2001.0826_RF31","first-page":"21","article-title":"Pharmacological basis of cypermethrin neurotoxicity","volume":"67","author":"Tandon","year":"1990","journal-title":"Indian Vet J"},{"key":"10.1006\/phrs.2001.0826_RF32","doi-asserted-by":"crossref","unstructured":"D, M, Soderlund, J, E, Casida, Synthetic pyethroids, ACS Symposia 1977, Series No. 42, p. 162","DOI":"10.1021\/bk-1977-0042.ch015"},{"key":"10.1006\/phrs.2001.0826_RF33","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/BF01969923","article-title":"Acute toxicity of two pyrethroids, permethrin and cypermethrin in neonatal & adult rats","volume":"67","author":"Cantalamessa","year":"1993","journal-title":"Arch Toxicol"}],"container-title":["Pharmacological Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661801908266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043661801908266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:13:12Z","timestamp":1576519992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043661801908266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001,7]]}},"alternative-id":["S1043661801908266"],"URL":"https:\/\/doi.org\/10.1006\/phrs.2001.0826","relation":{},"ISSN":["1043-6618"],"issn-type":[{"value":"1043-6618","type":"print"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}