{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T05:39:32Z","timestamp":1792733972956,"version":"4.5.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"published-print":{"date-parts":[[2000,4]]},"DOI":"10.1006\/pupt.2000.0231","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T21:19:16Z","timestamp":1032383956000},"page":"61-69","source":"Crossref","is-referenced-by-count":96,"title":["Lipopolysaccharide-induced Lung Injury in Mice. I. Concomitant Evaluation of Inflammatory Cells and Haemorrhagic Lung Damage"],"prefix":"10.1006","volume":"13","author":[{"given":"C.","family":"Asti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Ruggieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Porzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Chiusaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Melillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.F.","family":"Caselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/pupt.2000.0231_RF1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1164\/ajrccm\/141.2.471","article-title":"Macrophages and polymorphonuclear neutrophils in lung defence and injury","volume":"141","author":"Sibille","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1006\/pupt.2000.0231_RF2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/0167-5699(94)90137-6","article-title":"The acute phase response","volume":"15","author":"Baumann","year":"1994","journal-title":"Immunol. Today"},{"key":"10.1006\/pupt.2000.0231_RF3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/0140-6736(91)91452-Z","article-title":"Septic shock: pathogenesis","volume":"338","author":"Glauser","year":"1991","journal-title":"Lancet"},{"key":"10.1006\/pupt.2000.0231_RF4","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0167-5699(97)01161-4","article-title":"Neutrophil chloramines: missing links between innate and acquired immunity","volume":"18(12)","author":"Marcinkiewicz","year":"1997","journal-title":"Immunol Today"},{"key":"10.1006\/pupt.2000.0231_RF5","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1164\/ajrccm\/148.6_Pt_2.S31","article-title":"Adhesion molecules in the lung","volume":"148","author":"Pilewski","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1006\/pupt.2000.0231_RF6","first-page":"487","article-title":"Targets for potential therapy in patients developing emphysema","volume":"29","author":"Weibaum","year":"1993","journal-title":"Drugs of Today"},{"key":"10.1006\/pupt.2000.0231_RF7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1152\/jappl.1983.55.2.285","article-title":"Biochemical links between cigarette smoking and pulmonary emphysema","volume":"55","author":"Janoff","year":"1983","journal-title":"J Appl Physiol"},{"key":"10.1006\/pupt.2000.0231_RF8","doi-asserted-by":"crossref","first-page":"769","DOI":"10.7326\/0003-4819-85-6-769","article-title":"Idiopathic pulmonary fibrosis: clinical, histologic, radiographic, physiologic scintigraphic, cytologic and biochemical aspects","volume":"85","author":"Crystal","year":"1976","journal-title":"Ann Intern Med"},{"key":"10.1006\/pupt.2000.0231_RF9","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1056\/NEJM198204153061504","article-title":"Adult respiratory distress syndrome. Changing concepts of lung injury and repair","volume":"306","author":"Rinaldo","year":"1982","journal-title":"N Engl J Med"},{"key":"10.1006\/pupt.2000.0231_RF10","doi-asserted-by":"crossref","first-page":"S109","DOI":"10.1164\/ajrccm\/150.6_Pt_2.S109","article-title":"The role of proteinases in the pathogenesis of chronic bronchitis","volume":"150","author":"Stockley","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1006\/pupt.2000.0231_RF11","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0954-6111(98)90101-9","article-title":"Epithelial cell damage is induced by neutrophil-derived, not pseudomonas-derived, proteases in cystic fibrosis sputum","volume":"92","author":"Venaille","year":"1998","journal-title":"Respir Med"},{"key":"10.1006\/pupt.2000.0231_RF12","first-page":"1485","article-title":"The intratracheal administration of endotoxin and cytokine I. Characterization of LPS-induced IL-1 and TNF mRNA expression and the LPS-, IL-1- and TNF-induced inflammatory infiltrate","volume":"138(6)","author":"Ulich","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1006\/pupt.2000.0231_RF13","first-page":"1097","article-title":"Intratracheal injection of endotoxin and cytokine II. Interleukin-6 and Transforming Growth Factor Beta inhibit acute inflammation","volume":"138(5)","author":"Ulith","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1006\/pupt.2000.0231_RF14","first-page":"521","article-title":"The intratracheal administration of endotoxin and cytokine III. The Interleukin-1 receptor antagonist inhibits endotoxin- and IL-1-induced acute inflammation","volume":"138(3)","author":"Ulich","year":"1991","journal-title":"Am J Pathol"},{"key":"10.1006\/pupt.2000.0231_RF15","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2486\/indhealth.35.353","article-title":"Quantitative time-course profiles of bronchoalveolar lavage cells following intratracheal instillation of lipopolysaccharide in mice","volume":"35","author":"Hirano","year":"1997","journal-title":"Ind Health"},{"key":"10.1006\/pupt.2000.0231_RF16","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/j.1476-5381.1996.tb15356.x","article-title":"Effect of cyclo-oxygenase inhibitors and modulators of cyclic AMP formation on lipopolysaccharide-induced neutrophil infiltration in mouse lung","volume":"117","author":"Moraes","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1006\/pupt.2000.0231_RF17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/sj.bjp.0701649","article-title":"Effect of rolipram on cyclic AMP levels in alveolar macrophages and lipopolysaccharide-induced inflammation in mouse lung","volume":"123","author":"Moraes","year":"1998","journal-title":"Br J Pharmacol"},{"key":"10.1006\/pupt.2000.0231_RF18","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1164\/arrd.1986.133.1.149","article-title":"Animal models of emphysema","volume":"133","author":"Snider","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"10.1006\/pupt.2000.0231_RF19","unstructured":"Brandolini, L. Asti, C. Ruggieri, V. Caselli, G. F. Bertini, R. Lipopolysaccharide-induced Lung Injury in Mice II. Evaluation of functional damage in isolated parenchyma strips, In press"},{"key":"10.1006\/pupt.2000.0231_RF20","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0076-6879(84)05055-2","article-title":"Antimicrobial Activity of Myeloperoxidase","volume":"105","author":"Klebanoff","year":"1984","journal-title":"Methods in Enzymology"},{"key":"10.1006\/pupt.2000.0231_RF21","doi-asserted-by":"crossref","first-page":"8727","DOI":"10.1073\/pnas.90.18.8727","article-title":"Chemical, biochemical, pharmacokinetic, and biological properties of L-680,833: a potent, orally active monocyclic \u03b2-lactam inhibitor of human polymorphonuclear leukocyte elastase","volume":"90","author":"Doherty","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/pupt.2000.0231_RF22","doi-asserted-by":"crossref","first-page":"C101","DOI":"10.1007\/BF01996110","article-title":"Measurement of MPO activity as model for detection of granulocyte infiltration in different tissue","author":"Werner","year":"1992","journal-title":"Agents Actions, Special Conference Issue"},{"key":"10.1006\/pupt.2000.0231_RF23","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/0092-8674(91)90279-8","article-title":"Leukocyte-endothelial cell recognition: three (or more) steps to specificity and diversity","volume":"67","author":"Butcher","year":"1991","journal-title":"Cell"},{"key":"10.1006\/pupt.2000.0231_RF24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.4049\/jimmunol.155.2.525","article-title":"Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling","volume":"155","author":"Ley","year":"1995","journal-title":"J Immunol"},{"key":"10.1006\/pupt.2000.0231_RF25","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.1164\/ajrccm\/148.6_Pt_2.S75","article-title":"Adhesion molecules in allergic inflammation","volume":"148","author":"Smith","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1006\/pupt.2000.0231_RF26","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1164\/ajrccm\/150.6_Pt_2.S114","article-title":"The role of neutrophil elastase in chronic inflammation","volume":"150","author":"D\u00f6ring","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1006\/pupt.2000.0231_RF27","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1172\/JCI111015","article-title":"Elastase and \u03b11-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome","volume":"72","author":"Merritt","year":"1983","journal-title":"J Clin Inv"},{"key":"10.1006\/pupt.2000.0231_RF28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0065-7743(08)60733-2","article-title":"Human leukocyte elastase inhibitors","volume":"29","author":"Hlasta","year":"1994","journal-title":"Ann Rep Med Chem"},{"key":"10.1006\/pupt.2000.0231_RF29","doi-asserted-by":"crossref","unstructured":"Travis, J. Pike, R. Imamura, T. Potempa, J. The role of proteolytic enzymes in the development of pulmonary emphysema and periodontal disease, 1994, 150, S143, 146","DOI":"10.1164\/ajrccm\/150.6_Pt_2.S143"},{"key":"10.1006\/pupt.2000.0231_RF30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1006\/pupt.1997.0074","article-title":"Molecular mechanisms of glucocorticoid action in asthma","volume":"10","author":"Barnes","year":"1997","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1006\/pupt.2000.0231_RF31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1046\/j.1365-2567.1997.00252.x","article-title":"Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-\u03b1, IL-1\u03b2 and IL-10 by human leukocytes","volume":"91","author":"Van Furth","year":"1997","journal-title":"Immunology"},{"key":"10.1006\/pupt.2000.0231_RF32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0014-2999(94)90789-7","article-title":"Anti-tumour necrosis factor properties of non-peptide drugs in acute-phase responses","volume":"271","author":"Chen","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2000.0231_RF33","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/1043-4666(90)90032-O","article-title":"The effects of pentoxifylline on lipopolysaccharide (LPS) fever, plasma interleukin 6 (IL 6) and tumor necrosis factor (TNF) in the rat","volume":"2","author":"LeMay","year":"1990","journal-title":"Cytokine"},{"key":"10.1006\/pupt.2000.0231_RF34","first-page":"G993","article-title":"Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury","volume":"265","author":"Wallace","year":"1993","journal-title":"Am J Physiol"},{"key":"10.1006\/pupt.2000.0231_RF35","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/01902149709039228","article-title":"Intratracheal aerosolization of endotoxin (LPS) in the rat: a comprehensive animal model to study Adult Respiratory Distress Syndrome (ARDS)","volume":"23","author":"Van Helden","year":"1997","journal-title":"Exp Lung Res"}],"container-title":["Pulmonary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553900902311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553900902311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T19:46:17Z","timestamp":1680551177000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553900902311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["S1094553900902311"],"URL":"https:\/\/doi.org\/10.1006\/pupt.2000.0231","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}