{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:33:21Z","timestamp":1778279601738,"version":"3.51.4"},"reference-count":20,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pulmonary Pharmacology & Therapeutics"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1006\/pupt.2002.0350","type":"journal-article","created":{"date-parts":[[2002,9,25]],"date-time":"2002-09-25T18:55:31Z","timestamp":1032980131000},"page":"235-240","source":"Crossref","is-referenced-by-count":22,"title":["\u03b4-Opioid Receptor Antagonists as a New Concept for Central Acting Antitussive Drugs"],"prefix":"10.1006","volume":"15","author":[{"given":"Junzo","family":"Kamei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/pupt.2002.0350_RF1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(89)90764-4","article-title":"Modulation of \u03bc-mediated antinociception by \u03b4 agonists in the mouse: selective potentiation of morphine and normorphine by [D-Pen2, D-Pen5]enkephalin","volume":"165","author":"Heyman","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0014-2999(89)90815-7","article-title":"Modulation of \u03bc-mediated antinociception by \u03b4 agonists: characterization with antagonists","volume":"169","author":"Heyman","year":"1989","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF3","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0014-2999(91)90807-3","article-title":"Modulation of \u03bc-mediated antitussive activity in rats by \u03b4 agonist","volume":"203","author":"Kamei","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF4","first-page":"375","article-title":"Modulation of \u03ba-mediated antitussive activity in rats by a \u03b4 agonist","volume":"76","author":"Kamei","year":"1992","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF5","first-page":"1069","article-title":"Differential antagonism of opioid delta antinociception by [D-Ala2, Leu4, Cys6]enkephalin and naltrindole 5-isothiocyanate: evidence for delta receptor subtypes","volume":"257","author":"Jiang","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF6","first-page":"518","article-title":"Spinal opioid delta antinociception in the mouse; mediation by single subtype of opioid delta receptor","volume":"260","author":"Mattia","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF7","first-page":"676","article-title":"Differential antagonism of delta opioid agonists by naltrindole (NTI) and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes","volume":"257","author":"Sofuoglu","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF8","doi-asserted-by":"crossref","first-page":"PL153","DOI":"10.1016\/0024-3205(91)90397-T","article-title":"Cross-tolerance studies in the spinal cord of \u03b2-FNA-treated mice provides further evidence for delta opioid receptor subtypes","volume":"49","author":"Sofuoglu","year":"1991","journal-title":"Life Sci"},{"key":"10.1006\/pupt.2002.0350_RF9","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0014-2999(93)90714-S","article-title":"Differential modulation of \u03bc-opioid receptor-mediated antitussive activity by \u03b4-opioid receptor agonists in mice","volume":"234","author":"Kamei","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0014-2999(97)00085-X","article-title":"Supraspinal \u03b41-opioid receptor-mediated antinociceptive properties of (\u2212)-TAN-67 in diabetic mice","volume":"322","author":"Kamei","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0014-2999(92)90072-C","article-title":"Antitussive effects of Ca2+ channel antagonists","volume":"212","author":"Kamei","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF12","first-page":"134","article-title":"Pharmacologic studies on analgesics","volume":"153","author":"Kakunaga","year":"1966","journal-title":"VII. Significance of the calcium ion in morphine analgesia. J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF13","first-page":"488","article-title":"Effects of divalent cations, cation chelators and an ionophore on morphine analgesia and tolerance","volume":"195","author":"Harris","year":"1975","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF14","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0031-6989(84)80065-X","article-title":"Potentiation of thermoregulatory and analgesic effects of morphine by calcium antagonists","volume":"16","author":"Benedek","year":"1984","journal-title":"Pharmacol Res Commun"},{"key":"10.1006\/pupt.2002.0350_RF15","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-2999(87)90216-0","article-title":"Analgesic effects of several calcium channel blockers in mice","volume":"137","author":"Del Pozo","year":"1987","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF16","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0014-2999(88)90129-X","article-title":"Calcium channel antagonists increase morphine-induced analgesia and antagonize morphine tolerance","volume":"148","author":"Contreras","year":"1988","journal-title":"Eur J Pharmacol"},{"key":"10.1006\/pupt.2002.0350_RF17","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1471-4159.1993.tb03234.x","article-title":"Morphine activates omega-conotoxin-sensitive Ca2+ channels to release adenosine from spinal cord synaptosomes","volume":"60","author":"Cahill","year":"1993","journal-title":"J Neurochem"},{"key":"10.1006\/pupt.2002.0350_RF18","first-page":"290","article-title":"Calcium modulation of morphine analgesia: role of calcium channels and intracellular pool calcium","volume":"272","author":"Smith","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF19","first-page":"780","article-title":"Role of intracellular calcium in modification of mu and delta opioid receptor-mediated antinociception by diabetes in mice","volume":"286","author":"Ohsawa","year":"1998","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1006\/pupt.2002.0350_RF20","first-page":"803","article-title":"The antitussive activity of \u03b4-opioid receptor stimulation in guinea pigs","volume":"292","author":"Kotzer","year":"2000","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Pulmonary Pharmacology & Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553902903500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094553902903500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T14:22:30Z","timestamp":1554992550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094553902903500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S1094553902903500"],"URL":"https:\/\/doi.org\/10.1006\/pupt.2002.0350","relation":{},"ISSN":["1094-5539"],"issn-type":[{"value":"1094-5539","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}