{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:28:25Z","timestamp":1760203705430},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Regulatory Toxicology and Pharmacology"],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1006\/rtph.2002.1553","type":"journal-article","created":{"date-parts":[[2002,8,30]],"date-time":"2002-08-30T18:48:10Z","timestamp":1030733290000},"page":"338-346","source":"Crossref","is-referenced-by-count":20,"title":["Evaluation of the Adequacy of Published Studies of Low-Dose Effects of Bisphenol A on the Rodent Prostate for Use in Human Risk Assessment"],"prefix":"10.1006","volume":"35","author":[{"given":"Harry A.","family":"Milman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maarten C.","family":"Bosland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul D.","family":"Walden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John E.","family":"Heinze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/rtph.2002.1553_RF1","doi-asserted-by":"crossref","first-page":"A315","DOI":"10.2307\/3434050","article-title":"The importance of protocol design and data reporting to research on endocrine disruption","volume":"106","author":"Ashby","year":"1998","journal-title":"Environ. Health Perspect"},{"key":"10.1006\/rtph.2002.1553_RF2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/rtph.1999.1317","article-title":"Lack of effects of low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF-1 mice exposed in utero","volume":"30","author":"Ashby","year":"1999","journal-title":"Regul. Toxicol. Pharmacol"},{"key":"10.1006\/rtph.2002.1553_RF3","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/11250009309355826","article-title":"Physiological responses to social status and housing conditions in male mice subject to food competition tests","volume":"60","author":"Bartos","year":"1993","journal-title":"Bull. Zool"},{"key":"10.1006\/rtph.2002.1553_RF4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1210\/endo-48-1-25","article-title":"Estrogen and alkaline phosphatase activity in the genital tract of the male mouse","volume":"48","author":"Bern","year":"1951","journal-title":"Endocrinology"},{"key":"10.1006\/rtph.2002.1553_RF5","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S1078-1439(97)82840-2","article-title":"Chemical and hormonal induction of prostate cancer in animal models","volume":"2","author":"Bosland","year":"1996","journal-title":"Urol. Oncol"},{"key":"10.1006\/rtph.2002.1553_RF6","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/carcin\/16.6.1311","article-title":"Induction at high incidence of ductal prostate adenocarcinomas in NBL\/Cr and Sprague-Dawley Hsd:SD rats treated with a combination of testosterone and estradiol-17\u03b2 or diethylstilbestrol","volume":"16","author":"Bosland","year":"1995","journal-title":"Carcinogenesis"},{"key":"10.1006\/rtph.2002.1553_RF7","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/toxsci\/50.1.36","article-title":"Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A","volume":"50","author":"Cagen","year":"1999","journal-title":"Toxicol. Sci"},{"key":"10.1006\/rtph.2002.1553_RF8","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/rtph.1999.1340","article-title":"Normal reproductive organ development in Wistar rats exposed to bisphenol A in the drinking water","volume":"30","author":"Cagen","year":"1999","journal-title":"Regul. Toxicol. Pharmacol"},{"key":"10.1006\/rtph.2002.1553_RF9","year":"1997","journal-title":"Statement on Bisphenol A"},{"key":"10.1006\/rtph.2002.1553_RF10","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1159\/000130000","article-title":"XX\/YY chimerism in a bovine true hermaphrodite: An insight into the understanding of freemartinism","volume":"7","author":"Dunn","year":"1968","journal-title":"Cytogenetics"},{"key":"10.1006\/rtph.2002.1553_RF11","first-page":"256","article-title":"Effects of perinatal exposure to low doses of bisphenol A in male offspring of Sprague Dawley rats","volume":"5","author":"Elswick","year":"2000","journal-title":"Toxicologist"},{"key":"10.1006\/rtph.2002.1553_RF12","unstructured":"Ema, M. 2000, Two-Generation Reproductive Study of Bisphenol A in Rats, Study Report SR-98101, Chemical Compound Safety Research Institute, Hokkaido, Japan."},{"key":"10.1006\/rtph.2002.1553_RF13","series-title":"Proceedings, International Symposium on Environmental Endocrine Disruptors '99, Dec. 9\u201312, 1999, Kobe, Japan","year":"1999"},{"key":"10.1006\/rtph.2002.1553_RF14","series-title":"Proceedings, International Symposium on Environmental Endocrine Disrupters 2000, Dec. 16\u201318, 2000, Yokohama, Japan","year":"2000"},{"key":"10.1006\/rtph.2002.1553_RF15","unstructured":"Environmental Protection Agency (EPA), 1999, Endocrine Disruptor Screening and Testing Advisory Committee (EDSTAC), final report, www.epa.gov\/scipoly\/oscpendo\/history\/finalrpt.htm."},{"key":"10.1006\/rtph.2002.1553_RF16","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-0045(19980215)34:3<214::AID-PROS9>3.0.CO;2-H","article-title":"Induction of atypical prostatic hyperplasia in rats by sympathomimetic stimulation","volume":"34","author":"Golomb","year":"1998","journal-title":"Prostate"},{"key":"10.1006\/rtph.2002.1553_RF17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1525-1373.2000.22402.x","article-title":"Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals","volume":"224","author":"Gupta","year":"2000","journal-title":"J. Soc. Exp. Biol. Med"},{"key":"10.1006\/rtph.2002.1553_RF18","unstructured":"Haseman, J, Bailer, J, Kodell, R, Morris, R, and, Portier, K. 2001, Chapter 5: Report of the Statistics Subpanel, Appendix 1, Detailed Evaluation of Individual Studies, final report. Endocrine Disruptors Low Dose Peer Review Panel, National Toxicology Program, Research Triangle Park, NC."},{"key":"10.1006\/rtph.2002.1553_RF19","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/44517","article-title":"Exposure to bisphenol A advances puberty","volume":"401","author":"Howdeshell","year":"1999","journal-title":"Nature"},{"key":"10.1006\/rtph.2002.1553_RF20","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1080\/02652039809374653","article-title":"Potential exposure to bisphenol A from food-contact use of polycarbonate resins","volume":"15","author":"Howe","year":"1998","journal-title":"Food Addit. Contam"},{"key":"10.1006\/rtph.2002.1553_RF21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF02720503","article-title":"Potential exposure to bisphenol A from food-contact use of epoxy coated cans","volume":"70","author":"Howe","year":"1998","journal-title":"J. Coatings Technol"},{"key":"10.1006\/rtph.2002.1553_RF22","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1210\/en.132.6.2279","article-title":"Bisphenol-A: An estrogenic substance is released from polycarbonate flasks during autoclaving","volume":"132","author":"Krishnan","year":"1993","journal-title":"Endocrinology"},{"key":"10.1006\/rtph.2002.1553_RF23","unstructured":"Lamb, J. C.1997. Can Today's Risk Assessment Paradigm Deal with Endocrine Active Chemicals? Risk Policy Report, pp. 30\u201333."},{"key":"10.1006\/rtph.2002.1553_RF24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1289\/ehp.9710570","article-title":"Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol","volume":"105","author":"Nagel","year":"1997","journal-title":"Environ. Health Perspect"},{"key":"10.1006\/rtph.2002.1553_RF25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1293\/tox.4.183","article-title":"Morphological abnormality of the epithelium in the prostate gland of spontaneously hypertensive rats","volume":"4","author":"Nakamura","year":"1991","journal-title":"J. Toxicol. Pathol"},{"key":"10.1006\/rtph.2002.1553_RF26","unstructured":"National Institute of Environmental Health Sciences (NIEHS), 2001, Report of the Endocrine Disruptors Low-Dose Peer Review Panel, final report dated, May 14, 2001, http:\/\/ntp-server.niehs.nih.gov\/htdocs\/liason\/LowDoseWebPage.html."},{"key":"10.1006\/rtph.2002.1553_RF27","series-title":"Hormonally Active Agents in the Environment","year":"1991"},{"key":"10.1006\/rtph.2002.1553_RF28","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1095\/biolreprod47.5.723","article-title":"Intrauterine position effects on steroid metabolism and steroid receptors of reproductive organs of male mice","volume":"47","author":"Nonneman","year":"1992","journal-title":"Biol. Reprod"},{"key":"10.1006\/rtph.2002.1553_RF29","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/0041-008X(92)90200-C","article-title":"Differential effects of diethylstilbestrol and estradiol-17\u03b2 in combination with testosterone on rat prostate lobes","volume":"112","author":"Ofner","year":"1992","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1006\/rtph.2002.1553_RF30","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1289\/ehp.951031136","article-title":"Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production","volume":"103","author":"Sharpe","year":"1995","journal-title":"Environ. Health Perspect"},{"key":"10.1006\/rtph.2002.1553_RF31","first-page":"S23","article-title":"Exposure of adult female rats to environmental oestrogens during gestation and lactation results in reduced testis size and sperm production in the male offspring in adult life","author":"Sharpe","year":"1996","journal-title":"Abstracts, 10th International Congress of Endocrinology"},{"key":"10.1006\/rtph.2002.1553_RF32","doi-asserted-by":"crossref","first-page":"A220","DOI":"10.2307\/3433998","article-title":"Endocrine disruptors and testis development","volume":"106","author":"Sharpe","year":"1998","journal-title":"Environ. Health Perspect"},{"key":"10.1006\/rtph.2002.1553_RF33","series-title":"Proceedings, Dose\u2013Response Considerations for Potential Endocrine Active Substances. April 15\u201316, 1999, Washington, DC","year":"1999"},{"key":"10.1006\/rtph.2002.1553_RF34","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/S0022-5347(05)69007-6","article-title":"Prostate gland growth during development is stimulated in both male and female rat fetuses by intrauterine proximity to female fetuses","volume":"161","author":"Timms","year":"1999","journal-title":"J. Urol"},{"key":"10.1006\/rtph.2002.1553_RF35","unstructured":"Tuohimaa, P.1980. Control of cell proliferation in male accessory sex glands. In Male Accessory Sex GlandsE. Spring-Mills and E. S. E. Hafez, Eds., pp. 131\u2013153. Elsevier\/North Holland, Amsterdam."},{"key":"10.1006\/rtph.2002.1553_RF36","unstructured":"Tyl, R. W, Myers, C. B, and, Marr, M. C. 2000, Three-Generation Reproductive Toxicity Evaluation of Bisphenol A Administered in the Feed to CD (Sprague-Dawley) Rats, Study Report 65C-07036\u2013000, Research Triangle Institute, Research Triangle Park, NC."},{"key":"10.1006\/rtph.2002.1553_RF37","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/carcin\/12.2.289","article-title":"Magnetic resonance imaging compared with hormonal effects and histopathology of estrogen-induced pituitary lesions in the rat","volume":"12","author":"Van Nesselrooij","year":"1991","journal-title":"Carcinogenesis"},{"key":"10.1006\/rtph.2002.1553_RF38","first-page":"134","article-title":"Bisphenol A alters development in mice at human exposure levels","author":"Vom Saal","year":"2000","journal-title":"Proceedings, International Symposium on Environmental Endocrine Disrupters 2000"},{"key":"10.1006\/rtph.2002.1553_RF39","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/074823379801400115","article-title":"A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior","volume":"14","author":"Vom Saal","year":"1998","journal-title":"Toxicol. Ind. Health"},{"key":"10.1006\/rtph.2002.1553_RF40","first-page":"60","article-title":"Dose\u2013response studies with xenoestrogens","author":"Welsch","year":"1999","journal-title":"Proceedings, The Toxicology Forum"},{"key":"10.1006\/rtph.2002.1553_RF41","first-page":"73","article-title":"Lack of effects of perinatal exposure to low doses of bisphenol A on male rat offspring ventral prostate glands","volume":"60","author":"Welsch","year":"2001","journal-title":"Toxicologist"},{"key":"10.1006\/rtph.2002.1553_RF42","unstructured":"Welsch, F, Elswick, B. A, and, Stedman, D. B. 2000, Effects of perinatal exposure to low doses of bisphenol A on female offspring of Sprague-Dawley rats, Toxicol. Sci, 54, 256A."}],"container-title":["Regulatory Toxicology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230002915539?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0273230002915539?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T19:25:34Z","timestamp":1554924334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0273230002915539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["S0273230002915539"],"URL":"https:\/\/doi.org\/10.1006\/rtph.2002.1553","relation":{},"ISSN":["0273-2300"],"issn-type":[{"value":"0273-2300","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}