{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:26:20Z","timestamp":1790756780771,"version":"4.1.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Cell &amp; Developmental Biology"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1006\/scdb.2001.0277","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T17:19:16Z","timestamp":1032369556000},"page":"397-405","source":"Crossref","is-referenced-by-count":26,"title":["Lessons from mitochondrial DNA mutations"],"prefix":"10.1006","volume":"12","author":[{"given":"Salvatore","family":"DiMauro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/scdb.2001.0277_RF1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"10.1006\/scdb.2001.0277_RF2","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1212\/WNL.13.11.919","article-title":"Rapid examination of muscle tissue: an improved trichome stain method for fresh\u2013frozen biopsy sections","volume":"13","author":"Engel","year":"1963","journal-title":"Neurology"},{"key":"10.1006\/scdb.2001.0277_RF3","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1093\/hmg\/3.3.449","article-title":"Extremely high levels of mutant mtDNAs co-localize with cytochrome c oxidase-negative ragged-red fibers in patients harboring a point mutation at nt 3243","volume":"3","author":"Petruzzella","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.1006\/scdb.2001.0277_RF4","first-page":"239","article-title":"Rearranged mitochondrial genomes are present in human oocytes","volume":"57","author":"Chen","year":"1995","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1022685929755","article-title":"Mitochondrial DNA mutations and pathogenesis","volume":"29","author":"Schon","year":"1997","journal-title":"J Bioenerg Biomembr"},{"key":"10.1006\/scdb.2001.0277_RF6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1750-3639.2000.tb00275.x","article-title":"Mutations in mtDNA: are we scraping the bottom of the barrel?","volume":"10","author":"DiMauro","year":"2000","journal-title":"Brain Pathol"},{"key":"10.1006\/scdb.2001.0277_RF7","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/ng0793-289","article-title":"Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness","volume":"4","author":"Prezant","year":"1993","journal-title":"Nature Genet"},{"key":"10.1006\/scdb.2001.0277_RF8","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1086\/302188","article-title":"Maternally inherited cardiomyopathy: an atypical presentation of the 12S rRNA A1555G mutation","volume":"64","author":"Santorelli","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF9","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/1531-8249(200011)48:5<730::AID-ANA6>3.0.CO;2-0","article-title":"A novel mitochondrial 12S rRNA point mutation in Parkinsonism, deafness and neuropathy","volume":"48","author":"Thyagarajan","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF10","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.3201231","article-title":"Mitochondrial DNA mutation associated with Leber\u2019s hereditary optic neuropathy","volume":"242","author":"Wallace","year":"1988","journal-title":"Science"},{"key":"10.1006\/scdb.2001.0277_RF11","first-page":"1147","article-title":"A new mtDNA mutation associated with Leber hereditary optic neuroretinopathy","volume":"48","author":"Huoponen","year":"1991","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF12","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1016\/0006-291X(92)90479-5","article-title":"An ND-6 mitochondrial DNA mutation associated with Leber hereditary optic neuropathy","volume":"187","author":"Johns","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1006\/scdb.2001.0277_RF13","first-page":"428","article-title":"A new mitochondrial disease associated with mitochondrial DNA heteroplasmy","volume":"46","author":"Holt","year":"1990","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF14","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1002\/ana.410340319","article-title":"A second missense mutation in the mitochondrial ATPase 6 gene in Leigh\u2019s syndrome","volume":"34","author":"De Vries","year":"1993","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0887-8994(95)00184-H","article-title":"Bilateral striatal necrosis with a novel point mutation in the mitochondrial ATPase 6 gene","volume":"13","author":"De Meirleir","year":"1995","journal-title":"Pediatr Neurol"},{"key":"10.1006\/scdb.2001.0277_RF16","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1002\/1531-8249(199906)45:6<820::AID-ANA22>3.0.CO;2-W","article-title":"Exercise intolerance due to a nonsense mutation in the mtDNA ND4 gene","volume":"45","author":"Andreu","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF17","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1086\/302927","article-title":"Intragenic inversion of mtDNA: a new type of pathogenic mutation in a patient with mitochondrial myopathy","volume":"66","author":"Musumeci","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF18","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s100720050056","article-title":"Exercise intolerance and the mitochondrial respiratory chain","volume":"20","author":"DiMauro","year":"1999","journal-title":"Ital J Neurol Sci"},{"key":"10.1006\/scdb.2001.0277_RF19","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1056\/NEJM199909303411404","article-title":"Exercise intolerance due to mutations in the cytochrome b gene of mitochondrial DNA","volume":"341","author":"Andreu","year":"1999","journal-title":"New Engl J Med"},{"key":"10.1006\/scdb.2001.0277_RF20","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1086\/316900","article-title":"Mitochondrial encephalomyopathy and complex III deficiency associated with a stop-codon mutation in the cytochrome b gene","volume":"67","author":"Keightley","year":"2000","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF21","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/ng0496-410","article-title":"A microdeletion in cytochrome c oxidase (COX) subunit III associated with COX deficiency and recurrent myoglobinuria","volume":"12","author":"Keightley","year":"1996","journal-title":"Nat Genet"},{"key":"10.1006\/scdb.2001.0277_RF22","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1212\/WNL.55.5.644","article-title":"Recurrent myoglobinuria due to a nonsense mutation in the COX I gene of mtDNA","volume":"55","author":"Karadimas","year":"2000","journal-title":"Neurology"},{"key":"10.1006\/scdb.2001.0277_RF23","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1006\/bbrc.1997.7167","article-title":"Identification of a novel mutation in the mtDNA ND5 gene associated with MELAS","volume":"238","author":"Santorelli","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1006\/scdb.2001.0277_RF24","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/1531-8249(199912)46:6<916::AID-ANA16>3.0.CO;2-R","article-title":"The mitochondrial DNA G13513A transition in ND5 is associated with a LHON\/MELAS overlap syndrome and may be a frequent cause of MELAS","volume":"46","author":"Pulkes","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF25","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0960-8966(94)00079-O","article-title":"A new mutation associated with MELAS is located in a mitochondrial DNA polypeptide-coding gene","volume":"5","author":"Manfredi","year":"1995","journal-title":"Neuromuscul Disord"},{"key":"10.1006\/scdb.2001.0277_RF26","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1093\/hmg\/9.18.2733","article-title":"A novel frameshift mutation of the mtDNA COXIII gene leads to impaired assembly of cytochrome c oxidase in a patient affected by Leigh-like syndrome","volume":"9","author":"Tiranti","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1006\/scdb.2001.0277_RF27","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/ana.410430119","article-title":"Cytochrome c oxidase subunit I microdeletion in a patient with motor neuron disease","volume":"43","author":"Comi","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1203\/00006450-200009000-00008","article-title":"A missense mutation in the mitochondrial cytochrome b gene in a revisited case with histiocytoid cardiomyopathy","volume":"48","author":"Andreu","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1006\/scdb.2001.0277_RF29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s004390050988","article-title":"A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency","volume":"104","author":"Valnot","year":"1999","journal-title":"Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF30","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1182\/blood.V90.12.4961","article-title":"Heteroplasmic point mutations of mitochondrial DNA subunit I of cytochrome c oxidase in two patients with acquired idiopathic sideroblastic anemia","volume":"90","author":"Gattermann","year":"1997","journal-title":"Blood"},{"key":"10.1006\/scdb.2001.0277_RF31","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1126\/science.2814477","article-title":"Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation","volume":"246","author":"King","year":"1989","journal-title":"Science"},{"key":"10.1006\/scdb.2001.0277_RF32","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1002\/1531-8249(200003)47:3<381::AID-ANA17>3.0.CO;2-2","article-title":"Very low levels of the mtDNA A3243G mutation associated with mitochondrial dysfunction in vivo","volume":"47","author":"Chinnery","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF33","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/1531-8249(200002)47:2<179::AID-ANA7>3.0.CO;2-Z","article-title":"Oxidative phosphorylation defect in the brains of carriers of the tRNAleu (UUR) A3243G mutation in a MELAS pedigree","volume":"47","author":"Dubeau","year":"2000","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF34","article-title":"Metabolic, structural and neuropsychological deficits in mitochondrial encephalomyopathies assessed by 1H MRSI, MRI and neuropsychological testing","volume":"7","author":"Shungu","year":"1999","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"10.1006\/scdb.2001.0277_RF35","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/82826","article-title":"Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes","volume":"26","author":"Inoue","year":"2000","journal-title":"Nat Genet"},{"key":"10.1006\/scdb.2001.0277_RF36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/79832","article-title":"A debut for mito-mouse","volume":"26","author":"Shoubridge","year":"2000","journal-title":"Nat Genet"},{"key":"10.1006\/scdb.2001.0277_RF37","doi-asserted-by":"crossref","first-page":"14461","DOI":"10.1073\/pnas.250491597","article-title":"Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice","volume":"97","author":"Sligh","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/scdb.2001.0277_RF38","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1073\/pnas.98.2.401","article-title":"Transmitochondrial mice: proof of principle and promises","volume":"98","author":"Hirano","year":"2001","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1006\/scdb.2001.0277_RF39","doi-asserted-by":"crossref","first-page":"S901","DOI":"10.1007\/s100720070001","article-title":"Mitochondrial encephalomyopathies: therapeutic approaches","volume":"21","author":"DiMauro","year":"2000","journal-title":"Neurol Sci"},{"key":"10.1006\/scdb.2001.0277_RF40","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/ng0297-212","article-title":"Selective inhibition of mutant human mitochondrial DNA replication in vitro by peptide nucleic acids","volume":"15","author":"Taylor","year":"1997","journal-title":"Nat Genet"},{"key":"10.1006\/scdb.2001.0277_RF41","doi-asserted-by":"crossref","first-page":"9386","DOI":"10.1074\/jbc.274.14.9386","article-title":"Oligomycin induces a decrease in the cellular content of a pathogenic mutation in the human mitochondrial ATPase 6 gene","volume":"274","author":"Manfredi","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1006\/scdb.2001.0277_RF42","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/ng0797-222","article-title":"Reversal of a mitochondrial DNA defect in human skeletal muscle","volume":"16","author":"Clark","year":"1997","journal-title":"Nat Genet"},{"key":"10.1006\/scdb.2001.0277_RF43","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1093\/hmg\/5.11.1835","article-title":"A novel heteroplasmic tRNAleu(CUN) mtDNA point mutation in a sporadic patient with mitochondrial encephalomyopathy segregates rapidly in skeletal muscle and suggests an approach to therapy","volume":"5","author":"Fu","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1006\/scdb.2001.0277_RF44","doi-asserted-by":"crossref","first-page":"2239","DOI":"10.1093\/hmg\/6.13.2239","article-title":"Complete restoration of a wild-type mtDNA genotype in regenerating muscle fibers in a patient with a tRNA point mutation and mitochondrial encephalomyopathy","volume":"6","author":"Shoubridge","year":"1997","journal-title":"Hum Mol Genet"},{"key":"10.1006\/scdb.2001.0277_RF45","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/eye.1999.225","article-title":"Evaluation of bupivacaine-induced muscle regeneration in the treatment of ptosis in patients with chronic progressive external ophthalmoplegia and Kearns-Sayre syndrome","volume":"13","author":"Andrews","year":"1999","journal-title":"Eye"},{"key":"10.1006\/scdb.2001.0277_RF46","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/hmg\/8.6.1047","article-title":"Gene shifting: a novel therapy for mitochondrial myopathy","volume":"8","author":"Taivassalo","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1006\/scdb.2001.0277_RF47","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/humrep\/16.3.513","article-title":"Mitochondria in human offspring derived from ooplasmic transplantation","volume":"16","author":"Barritt","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1006\/scdb.2001.0277_RF48","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1017\/S0963180100006071","article-title":"Germ-line therapy to cure mitochondrial disease: protocol and ethics of in vitro ovum nuclear transplantation","volume":"4","author":"Rubenstein","year":"1995","journal-title":"Camb Q Healthc Ethics"},{"key":"10.1006\/scdb.2001.0277_RF49","doi-asserted-by":"crossref","DOI":"10.1016\/S1567-7249(01)00013-7","article-title":"The pros and cons of mitochondrial manipulation in the human germ line","author":"Thorburn","year":"2001","journal-title":"Mitochondrion 1 (in press)."},{"key":"10.1006\/scdb.2001.0277_RF50","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1023\/A:1005639407166","article-title":"Mitochondrial DNA mutations at nucleotide 8993 show a lack of tissue- or age-related variation","volume":"22","author":"White","year":"1999","journal-title":"J Inherit Metab Dis"},{"key":"10.1006\/scdb.2001.0277_RF51","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1002\/(SICI)1097-0223(199912)19:12<1165::AID-PD719>3.0.CO;2-D","article-title":"Two cases of prenatal analysis for the pathogenic T to G substitution at nucleotide 8993 in mitochondrial DNA","volume":"19","author":"White","year":"1999","journal-title":"Prenat Diagn"},{"key":"10.1006\/scdb.2001.0277_RF52","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1006\/mcpr.1996.0053","article-title":"A novel gly290asp mitochondrial cytochrome b mutation linked to a complex III deficiency in progressive exercise intolerance","volume":"10","author":"Dumoulin","year":"1996","journal-title":"Mol Cell Probes"},{"key":"10.1006\/scdb.2001.0277_RF53","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1212\/WNL.51.5.1444","article-title":"Missense mutation in the mtDNA cytochrome b gene in a patient with myopathy","volume":"51","author":"Andreu","year":"1998","journal-title":"Neurology"},{"key":"10.1006\/scdb.2001.0277_RF54","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/1531-8249(199901)45:1<127::AID-ART20>3.0.CO;2-Y","article-title":"A nonsense mutation (G15059A) in the cytochrome b gene in a patient with exercise intolerance and myoglobinuria","volume":"45","author":"Andreu","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF55","article-title":"A novel nonsense mutation (Q352X) in the mitochondrial cytochrome b gene associated with a combined defect of complexes I and III","author":"Lamantea","year":"2001","journal-title":"Neuromuscl Disord (in press)"},{"key":"10.1006\/scdb.2001.0277_RF56","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1086\/302590","article-title":"A missense mutation of cytochrome oxidase subunit II causes defective assembly and myopathy","volume":"65","author":"Rahman","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF57","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1006\/bbrc.1997.7167","article-title":"Identification of a novel mutation in the mtDNA ND5 gene associated with MELAS","author":"Santorelli","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1006\/scdb.2001.0277_RF58","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/ana.1084","article-title":"Progressive mitochondrial disease resulting from a novel missense mutation in the mitochondrial DNA ND3 gene","volume":"50","author":"Taylor","year":"2001","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF59","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1006\/bbrc.1997.7166","article-title":"Bilateral striatal necrosis and MELAS associated with a new T3308C mutation in the mitochondrial ND1 gene","volume":"238","author":"Campos","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1006\/scdb.2001.0277_RF60","doi-asserted-by":"crossref","first-page":"6206","DOI":"10.1073\/pnas.91.13.6206","article-title":"A mitochondrial DNA mutation at nucleotide pair 14459 of the NADH dehydrogenase subunit 6 gene associated with maternally inherited Leber hereditary optic neuropathy and dystonia","volume":"91","author":"Jun","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1006\/scdb.2001.0277_RF61","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/1531-8249(199901)45:1<130::AID-ART21>3.0.CO;2-Z","article-title":"A 4-base pair deletion in the mitochondrial cytochrome b gene associated with Parkinsonism\/MELAS overlap syndrome","volume":"45","author":"De Coo","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF62","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1086\/302546","article-title":"A stop-codon mutation in the human mtDNA cytochrome c oxidase I gene disrupts the functional structure of complex IV","volume":"65","author":"Bruno","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF63","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1086\/302361","article-title":"A mtDNA mutation in the initiation codon of the cytochrome c oxidase subunit II results in lower levels of the protein and a mitochondrial encephalomyopathy","volume":"64","author":"Clark","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF64","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1086\/301910","article-title":"Cytochrome c oxidase deficiency associated with the first stop-codon point mutation in human mtDNA","volume":"63","author":"Hanna","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1006\/scdb.2001.0277_RF65","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/ana.410380321","article-title":"A novel mitochondrial ATPase 6 point mutation in familial bilateral striatal necrosis","volume":"38","author":"Thyagarajan","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1006\/scdb.2001.0277_RF66","series-title":"Mitochondrial Encephalomyopathies","first-page":"201","author":"DiMauro","year":"1997"}],"container-title":["Seminars in Cell &amp; Developmental Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952101902770?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1084952101902770?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,15]],"date-time":"2019-12-15T23:38:08Z","timestamp":1576453088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1084952101902770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":66,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S1084952101902770"],"URL":"https:\/\/doi.org\/10.1006\/scdb.2001.0277","relation":{},"ISSN":["1084-9521"],"issn-type":[{"value":"1084-9521","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}