{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:56:39Z","timestamp":1786978599279,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,7,1]],"date-time":"1998-07-01T00:00:00Z","timestamp":899251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[1998,7]]},"DOI":"10.1006\/taap.1998.8453","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:01:25Z","timestamp":1032372085000},"page":"117-122","source":"Crossref","is-referenced-by-count":20,"title":["Transport of Nickel across Monolayers of Human Intestinal Caco-2 Cells"],"prefix":"10.1006","volume":"151","author":[{"given":"Jonas","family":"Tallkvist","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Tj\u00e4lve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.1998.8453_TO988453RF1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0005-2736(91)90165-5","article-title":"Caco-2 cell line: A system for studying intestinal iron transfer across epithelial cell monolayers","volume":"1070","author":"Alvarez-Hernandez","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.1998.8453_TO988453RF2","first-page":"G275","article-title":"Intracellular iron regulates iron absorption and IRP activity in intestinal epithelial (Caco-2) cells","volume":"273","author":"Arredondo","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.1998.8453_TO988453RF3","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/jps.2600790604","article-title":"Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cells","volume":"79","author":"Artursson","year":"1990","journal-title":"J. Pharm. Sci."},{"key":"10.1006\/taap.1998.8453_TO988453RF4","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1023\/A:1018903931777","article-title":"Selective paracellular permeability in two models of intestinal absorption: Culture monolayers of human intestinal epithelial cells and rat intestinal segments","volume":"10","author":"Artursson","year":"1993","journal-title":"Pharm. Res."},{"key":"10.1006\/taap.1998.8453_TO988453RF5","series-title":"Epithelial Cell Culture","article-title":"Studying transport processes in absorptive epithelia","author":"Artursson","year":"1996"},{"key":"10.1006\/taap.1998.8453_TO988453RF6","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1242\/jcs.107.12.3301","article-title":"ATP depletion: A novel method to study junctional properties in epithelial tissues. I. Rearrangement of the actin cytoskeleton","volume":"107","author":"Bacallao","year":"1994","journal-title":"J. Cell Sci."},{"key":"10.1006\/taap.1998.8453_TO988453RF7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01871231","article-title":"Common characteristics for Na+","volume":"99","author":"Blais","year":"1987","journal-title":"J. Membr. Biol."},{"key":"10.1006\/taap.1998.8453_TO988453RF8","first-page":"1936","article-title":"Epithelial polarity, villin expression and enterocytic differentiation of cultured human colon carcinoma cells: A survey of twenty cell lines","volume":"48","author":"Chantret","year":"1988","journal-title":"Cancer Res."},{"key":"10.1006\/taap.1998.8453_TO988453RF9","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/0016-5085(90)90344-Z","article-title":"The transport of vitamin B12 through polarized monolayers of Caco-2 cells","volume":"98","author":"Dix","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1006\/taap.1998.8453_TO988453RF10","first-page":"G1037","article-title":"Vitamin D-sensitive and quinacrine-sensitive zinc transport in human intestinal cell line Caco-2","volume":"264","author":"Fleet","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.1998.8453_TO988453RF11","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/jnci\/59.1.221","article-title":"One hundred and twenty-seven cultured human tumour cell lines producing tumours in nude mice","volume":"59","author":"Fogh","year":"1977","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1006\/taap.1998.8453_TO988453RF12","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/0300-483X(86)90170-8","article-title":"On the mechanism of nickel absorption in the rat jejunum","volume":"38","author":"Foulkes","year":"1986","journal-title":"Toxicology"},{"key":"10.1006\/taap.1998.8453_TO988453RF13","first-page":"G134","article-title":"Kinetics of transepithelial movement of heavy metals in rat jejunum","volume":"253","author":"Foulkes","year":"1987","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.1998.8453_TO988453RF14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/jcp.1041580104","article-title":"Iron absorption by Caco-2 cells cultivated in serum-free medium as anin vitro","volume":"158","author":"Halleux","year":"1994","journal-title":"J. Cell. Phys."},{"key":"10.1006\/taap.1998.8453_TO988453RF15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0167-4889(92)90226-2","article-title":"Transport of a large neutral amino acid in the human intestinal epithelial line (Caco-2): Uptake and efflux of phenylalanine","volume":"1135","author":"Hu","year":"1992","journal-title":"Biochim. Biophys. Acta."},{"key":"10.1006\/taap.1998.8453_TO988453RF16","unstructured":"Karlsson, J. 1995, Drug absorption in cell culture models of the intestinal epithelium, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 128, Uppsala University, Sweden"},{"key":"10.1006\/taap.1998.8453_TO988453RF17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1079\/BJN19930023","article-title":"Effect of dietary calcium level on mineral and trace element utilization from a rapeseed (Brassica napus L.) diet fed to ileum-fistulated pigs","volume":"69","author":"Larsen","year":"1993","journal-title":"Br. J. Nutr."},{"key":"10.1006\/taap.1998.8453_TO988453RF18","unstructured":"Lindmark, T. 1997, Drug absorption enhancement in the intestinal epithelium using medium chain fatty acids, Comprehensive Summaries of Uppsala Dissertations from the Faculty of Pharmacy, 164, Uppsala University, Sweden"},{"key":"10.1006\/taap.1998.8453_TO988453RF19","unstructured":"Lundin, A. 1990, Clinical applications of luminometric ATP monitoring, Karolinska Institutet, Sweden"},{"key":"10.1006\/taap.1998.8453_TO988453RF20","doi-asserted-by":"crossref","unstructured":"Mandel, L. J. 1986, Energy metabolism of cellular activation, growth, and transformation, Mandel, L. J.Benos, D. J. The Role of Membranes in Cell Growth and Differentiation, Academic Press, New York, 261, 291","DOI":"10.1016\/S0070-2161(08)60359-7"},{"key":"10.1006\/taap.1998.8453_TO988453RF21","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0271-5317(05)80777-8","article-title":"Cadmium accumulation from diets with and without wheat bran in rats with different iron-status","volume":"12","author":"Moberg Wing","year":"1992","journal-title":"Nutr. Res."},{"key":"10.1006\/taap.1998.8453_TO988453RF22","unstructured":"Neutra, M. Louvard, D. 1989, Differentiation of intestinal cellsin vitro, Modern Cell Biology: Functional Epithelial Cells in Culture, K. S. MaitlinJ. D. Valentich, 363, 398, A. R. Liss, New York"},{"key":"10.1006\/taap.1998.8453_TO988453RF23","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/0167-4889(95)00118-C","article-title":"The transport of acidic amino acids and their analogues across monolayers of human intestinal absorptive (Caco-2) cellsin vitro","volume":"1269","author":"Nicklin","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.1998.8453_TO988453RF24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/taap.1996.8039","article-title":"A study of cadmium transport pathways using the Caco-2 cell model","volume":"142","author":"Pigman","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1998.8453_TO988453RF25","first-page":"323","article-title":"Enterocyte-like differentiation and polarization of the human colon carcinoma cell line Caco-2 in culture","volume":"47","author":"Pinto","year":"1983","journal-title":"Biol. Cell"},{"key":"10.1006\/taap.1998.8453_TO988453RF26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jcp.1041520217","article-title":"Distinct mechanisms of zinc uptake at the apical and basolateral membranes of Caco-2 cells","volume":"152","author":"Raffanielo","year":"1992","journal-title":"J. Cell. Physiol."},{"key":"10.1006\/taap.1998.8453_TO988453RF27","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1093\/jn\/126.6.1701","article-title":"High zinc concentrations in culture media affect copper uptake and transport in differentiated human colon adenocarcinoma cells","volume":"126","author":"Reeves","year":"1996","journal-title":"J. Nutr."},{"key":"10.1006\/taap.1998.8453_TO988453RF28","first-page":"G361","article-title":"Nitric oxide dilates tight junctions and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers","volume":"268","author":"Salzman","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.1998.8453_TO988453RF29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0773.1994.tb00354.x","article-title":"Nickel absorption from perfused rat jejunal and ileal segments","volume":"75","author":"Tallkvist","year":"1994","journal-title":"Pharmacol. Toxicol."},{"key":"10.1006\/taap.1998.8453_TO988453RF30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0773.1994.tb00355.x","article-title":"Enhanced intestinal nickel absorption in iron-deficient rats","volume":"75","author":"Tallkvist","year":"1994","journal-title":"Pharmacol. Toxicol."},{"key":"10.1006\/taap.1998.8453_TO988453RF31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0378-4274(97)00051-9","article-title":"Effect of dietary iron-deficiency on the disposition of nickel in rats","volume":"92","author":"Tallkvist","year":"1997","journal-title":"Toxicol. Lett."},{"key":"10.1006\/taap.1998.8453_TO988453RF32","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1006\/bbrc.1993.1838","article-title":"Direct assessment of dipeptide\/H+","volume":"194","author":"Thwaites","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.1998.8453_TO988453RF33","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1165\/ajrcmb\/2.4.355","article-title":"The conductance of cultured epithelial cell monolayers: oxidants, adenosine triphosphate, and phorbol dibutyrate","volume":"2","author":"Winter","year":"1990","journal-title":"Am. J. Respir. Cell Mol. Biol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X98984538?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X98984538?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T02:34:25Z","timestamp":1620009265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X98984538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["S0041008X98984538"],"URL":"https:\/\/doi.org\/10.1006\/taap.1998.8453","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}