{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:44:40Z","timestamp":1773290680106,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[1998,9]]},"DOI":"10.1006\/taap.1998.8491","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"99-106","source":"Crossref","is-referenced-by-count":88,"title":["Myopathy Induced by HMG\u2013CoA Reductase Inhibitors in Rabbits: A Pathological, Electrophysiological, and Biochemical Study"],"prefix":"10.1006","volume":"152","author":[{"given":"Keiichi","family":"Nakahara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshito","family":"Sonoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Yoshidome","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiro","family":"Fujiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuro","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Osame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.1998.8491_TO988491RF1","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1177\/10.6.741","article-title":"Histochemical methods for acid phosphatase using hexagonium pararosanilin as coupler","volume":"10","author":"Barka","year":"1962","journal-title":"J. Histochem. Cytochem."},{"key":"10.1006\/taap.1998.8491_TO988491RF2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000186289","article-title":"Rhabdomyolysis with simvastatin use","volume":"57","author":"Berland","year":"1991","journal-title":"Nephron"},{"key":"10.1006\/taap.1998.8491_TO988491RF3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1001\/jama.1988.03410020105038","article-title":"Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients","volume":"260","author":"Corpier","year":"1988","journal-title":"JAMA"},{"key":"10.1006\/taap.1998.8491_TO988491RF4","series-title":"Muscle Biopsy: A Modern Approach","author":"Dubowitz","year":"1973"},{"key":"10.1006\/taap.1998.8491_TO988491RF5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1056\/NEJM198801073180111","article-title":"Rhabdomyolysis in patients receiving lovastatin after cardiac transplantation","volume":"318","author":"East","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/taap.1998.8491_TO988491RF6","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.1073\/pnas.87.22.8931","article-title":"Lovastatin decreases coenzyme Q levels in humans","volume":"87","author":"Folkers","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/taap.1998.8491_TO988491RF7","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/BF02576234","article-title":"Effects of HMG\u2013CoA reductase inhibitors on skeletal muscles of rabbits","volume":"193","author":"Fukami","year":"1993","journal-title":"Res. Exp. Med."},{"key":"10.1006\/taap.1998.8491_TO988491RF8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1006\/taap.1998.8491_TO988491RF9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1097\/00041433-199002000-00007","article-title":"The HMG CoA reductase inhibitors","volume":"1","author":"Hoeg","year":"1990","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1006\/taap.1998.8491_TO988491RF10","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1097\/00041433-199202000-00005","article-title":"HMG CoA reductase inhibitors","volume":"3","author":"Hunninghake","year":"1992","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1006\/taap.1998.8491_TO988491RF11","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1212\/WNL.41.7.1159","article-title":"Cholesterol-lowering agent myopathy (CLAM)","volume":"41","author":"London","year":"1991","journal-title":"Neurology"},{"key":"10.1006\/taap.1998.8491_TO988491RF12","doi-asserted-by":"crossref","first-page":"11524","DOI":"10.1016\/S0021-9258(17)39062-2","article-title":"Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells","volume":"260","author":"Maltese","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.1998.8491_TO988491RF13","doi-asserted-by":"crossref","first-page":"11B","DOI":"10.1016\/0002-9149(90)90435-4","article-title":"Extended clinical safety profile of lovastatin","volume":"66","author":"Mantell","year":"1990","journal-title":"Am. J. Cardiol."},{"key":"10.1006\/taap.1998.8491_TO988491RF14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/0022-510X(92)90273-N","article-title":"Experimental simvastatin-induced myopathy in rabbits","volume":"113","author":"Nakahara","year":"1992","journal-title":"J. Neurol. Sci."},{"key":"10.1006\/taap.1998.8491_TO988491RF15","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1006\/bbrc.1994.2112","article-title":"Cytosolic Ca2+","volume":"202","author":"Nakahara","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.1998.8491_TO988491RF16","series-title":"Biochemical and Clinical Aspects of Coenzyme Q","article-title":"Levels of coenzyme Q10 in biopsies of left ventricular muscle and influence of administration of coenzyme Q10","author":"Nobuyoshi","year":"1984"},{"key":"10.1006\/taap.1998.8491_TO988491RF17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1056\/NEJM198801073180110","article-title":"Myolysis and acute renal failure in a heart-transplant recipient receiving lovastatin","volume":"318","author":"Norman","year":"1988","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/taap.1998.8491_TO988491RF18","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1073\/pnas.86.7.2379","article-title":"Muscle coenzyme Q deficiency in familial mitochondral encephalomyopathy","volume":"86","author":"Ogasawara","year":"1989","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/taap.1998.8491_TO988491RF19","doi-asserted-by":"crossref","unstructured":"Ohno, K. Tanaka, M. Sahashi, K. Ibi, T. Sato, W. Yamamoto, T. Takahashi, A. Ozawa, T. 1991, Mitochondrial DNA deletions in inherited recurrent myoglobinuria, Ann Neurol. 29, 364, 369, 1991","DOI":"10.1002\/ana.410290406"},{"key":"10.1006\/taap.1998.8491_TO988491RF20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1001\/jama.1990.03450010075034","article-title":"Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy","volume":"264","author":"Pierce","year":"1990","journal-title":"JAMA"},{"key":"10.1006\/taap.1998.8491_TO988491RF21","doi-asserted-by":"crossref","first-page":"597","DOI":"10.7326\/0003-4819-109-7-597_2","article-title":"Lovastatin, nicotinic acid, and rhabdomyolysis","volume":"109","author":"Reaven","year":"1988","journal-title":"Ann. Intern. Med."},{"key":"10.1006\/taap.1998.8491_TO988491RF22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1056\/NEJM199208273270919","article-title":"Pravastatin-associated inflammatory myopathy","volume":"327","author":"Schalke","year":"1992","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/taap.1998.8491_TO988491RF23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.38.1.1","article-title":"Non-droplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (DAB)","volume":"38","author":"Seligman","year":"1968","journal-title":"J. Cell Biol."},{"key":"10.1006\/taap.1998.8491_TO988491RF24","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/jps.2600800905","article-title":"Relative lipophilicities, solubilities, and structure-pharmacological considerations of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG\u2013CoA) reductase inhibitors pravastatin, lovastatin, mevastatin, and simvastatin","volume":"80","author":"Serajuddin","year":"1991","journal-title":"J. Pharm. Sci."},{"key":"10.1006\/taap.1998.8491_TO988491RF25","first-page":"1225","article-title":"HMG\u2013CoA reductase inhibitor-induced myopathy in the rat: Cyclosporine A interaction and mechanism studies","volume":"257","author":"Smith","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.1998.8491_TO988491RF26","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/mus.880170808","article-title":"Electrical myotonia of rabbit skeletal muscles by HMG\u2013CoA reductase inhibitors","volume":"17","author":"Sonoda","year":"1994","journal-title":"Muscle Nerve"},{"key":"10.1006\/taap.1998.8491_TO988491RF27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1083\/jcb.32.2.415","article-title":"An electron transport system associated with the outer membrane of liver mitochondria","volume":"32","author":"Sottocasa","year":"1967","journal-title":"J. Cell Biol."},{"key":"10.1006\/taap.1998.8491_TO988491RF28","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0076-6879(69)13005-0","article-title":"Citrate synthase","volume":"13","author":"Srere","year":"1969","journal-title":"Methods Enzymol."},{"key":"10.1006\/taap.1998.8491_TO988491RF29","doi-asserted-by":"crossref","first-page":"28J","DOI":"10.1016\/0002-9149(88)90004-5","article-title":"Efficacy and long-term adverse effect pattern of lovastatin","volume":"62","author":"Tobert","year":"1988","journal-title":"Am. J. Cardiol."},{"key":"10.1006\/taap.1998.8491_TO988491RF30","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1097\/00005072-199309000-00012","article-title":"Experimental lovastatin myopathy","volume":"52","author":"Waclawik","year":"1993","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1006\/taap.1998.8491_TO988491RF31","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0076-6879(67)10048-7","article-title":"Cytochrome oxidase from beef heart mitochondria","volume":"10","author":"Wharton","year":"1967","journal-title":"Methods Enzymol."},{"key":"10.1006\/taap.1998.8491_TO988491RF32","doi-asserted-by":"crossref","first-page":"8928","DOI":"10.1073\/pnas.87.22.8928","article-title":"Lovastatin decreases coenzyme Q levels in rats","volume":"87","author":"Willis","year":"1990","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X98984915?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X98984915?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T06:34:08Z","timestamp":1620023648000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X98984915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["S0041008X98984915"],"URL":"https:\/\/doi.org\/10.1006\/taap.1998.8491","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}