{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:12:17Z","timestamp":1790921537088,"version":"4.1.0"},"reference-count":78,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1999,5,1]],"date-time":"1999-05-01T00:00:00Z","timestamp":925516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2003,5,25]],"date-time":"2003-05-25T00:00:00Z","timestamp":1053820800000},"content-version":"vor","delay-in-days":1485,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[1999,5]]},"DOI":"10.1006\/taap.1999.8652","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:01:25Z","timestamp":1032372085000},"page":"23-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":98,"title":["Induction of Apoptosis in Human T-Cells by Methyl Mercury: Temporal Relationship between Mitochondrial Dysfunction and Loss of Reductive Reserve"],"prefix":"10.1006","volume":"157","author":[{"given":"Bruce J.","family":"Shenker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai L.","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Insug","family":"O","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving M.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.1999.8652_RF1","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/S0076-6879(85)13073-9","article-title":"Determination of glutathione disulfide in biological samples","volume":"113","author":"Anderson","year":"1985","journal-title":"Methods Enzymol."},{"key":"10.1006\/taap.1999.8652_RF2","first-page":"33","article-title":"Kinase cascades regulating entry into apoptosis","volume":"61","author":"Anderson","year":"1997","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1006\/taap.1999.8652_RF3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(94)91963-1","article-title":"Intracellular glutathione (GSH) levels modulate mercuric chloride (MC)- and methylmercuric chloride (MeHgCl)-induced amino acid release from neonatal rat primary astrocytes cultures","volume":"664","author":"Aschner","year":"1994","journal-title":"Brain Res."},{"key":"10.1006\/taap.1999.8652_RF4","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1096\/fasebj.8.9.7516300","article-title":"Mechanisms of methylmercury-induced neurotoxicity","volume":"8","author":"Atchison","year":"1994","journal-title":"FASEB J."},{"key":"10.1006\/taap.1999.8652_RF5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/cimm.1995.1013","article-title":"Mercuric chloride-induced programmed cell death of a murine T cell hybridoma. 1. Effect of the proto-oncogene Bcl-2","volume":"161","author":"Aten","year":"1995","journal-title":"Cell. Immunol."},{"key":"10.1006\/taap.1999.8652_RF6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0165-7992(93)90068-7","article-title":"Liquid holding effects on methylmercury genotoxicity in human lymphocytes","volume":"301","author":"Betti","year":"1993","journal-title":"Mutat. Res."},{"key":"10.1006\/taap.1999.8652_RF7","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0167-5699(94)90018-3","article-title":"Oxidative stress as a mediator of apoptosis","volume":"15","author":"Buttke","year":"1995","journal-title":"Immunol. Today"},{"key":"10.1006\/taap.1999.8652_RF8","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1096\/fasebj.8.9.8005391","article-title":"Bcl-2 inhibits glucocorticoid-induced apoptosis but only partially blocks calcium ionophore or cycloheximide-regulated apoptosis in S49 cells","volume":"8","author":"Caron-Leslie","year":"1994","journal-title":"FASEB J."},{"key":"10.1006\/taap.1999.8652_RF9","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4049\/jimmunol.157.2.512","article-title":"Sequential acquisition of mitochondrial and plasma membrane alterations during early lymphocyte apoptosis","volume":"157","author":"Castedo","year":"1996","journal-title":"J. Immunol."},{"key":"10.1006\/taap.1999.8652_RF10","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1002\/eji.1830251212","article-title":"Mitochondrial perturbations define lymphocytes undergoing apoptotic depletionin vivo","volume":"25","author":"Castedo","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/taap.1999.8652_RF11","first-page":"19","article-title":"Epidemiologic assessment of measures used to indicate low-level exposure to mercury vapor (Hgo","volume":"52","author":"Cianciola","year":"1997","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1006\/taap.1999.8652_RF12","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3109\/10408369708998098","article-title":"The toxicology of mercury","volume":"34","author":"Clarkson","year":"1997","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1006\/taap.1999.8652_RF13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3260001","article-title":"Review article: Caspases: the executioners of apoptosis","volume":"326","author":"Cohen","year":"1997","journal-title":"Biochemistry"},{"key":"10.1006\/taap.1999.8652_RF14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3109\/08923979709046983","article-title":"Immunoglobulin E and autoantibodies in mercury-exposed workers","volume":"19","author":"Dantas","year":"1997","journal-title":"Immunopharm. Immunotox."},{"key":"10.1006\/taap.1999.8652_RF15","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0165-1110(94)90012-4","article-title":"Genotoxicity of mercury compounds. A review","volume":"317","author":"De Flora","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1006\/taap.1999.8652_RF16","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/clinchem\/41.12.1870","article-title":"Assessment of immunotoxic effects in humans","volume":"41","author":"Descotes","year":"1995","journal-title":"Clin. Chem."},{"key":"10.1006\/taap.1999.8652_RF17","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/0041-008X(83)90006-6","article-title":"Immunological and biochemical responses in mice treated with mercuric chloride","volume":"68","author":"Dieter","year":"1983","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8652_RF18","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.pa.35.040195.002013","article-title":"Risk assessment of environmental chemicals","volume":"35","author":"Fan","year":"1995","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1006\/taap.1999.8652_RF19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.4049\/jimmunol.155.1.66","article-title":"Bcl-xL","volume":"155","author":"Fang","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/taap.1999.8652_RF20","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/0024-3205(93)90042-2","article-title":"Methallothionein and glutathione as determinants of cellular retention and extrusion of cadmium and mercury","volume":"52","author":"Foulkes","year":"1993","journal-title":"Life Sci."},{"key":"10.1006\/taap.1999.8652_RF21","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0165-1218(94)90056-6","article-title":"Cytogenetic monitoring of fishermen with environmental mercury exposure","volume":"320","author":"Franchi","year":"1994","journal-title":"Mutat. Res."},{"key":"10.1006\/taap.1999.8652_RF22","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1242\/jcs.110.5.653","article-title":"Intracellular acidification induces apoptosis by stimulating ICE-like protease activity","volume":"110","author":"Furlong","year":"1997","journal-title":"J. Cell Sci."},{"key":"10.1006\/taap.1999.8652_RF23","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0008-8749(90)90184-S","article-title":"Macrophages regulate intracellular glutathione levels of lymphocytes. Evidence for an immunoregulatory role of cysteine","volume":"129","author":"Gmunder","year":"1990","journal-title":"Cell. Immunol."},{"key":"10.1006\/taap.1999.8652_RF24","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.275.5303.1081","article-title":"Controlling cell death","volume":"275","author":"Golstein","year":"1997","journal-title":"Science"},{"key":"10.1006\/taap.1999.8652_RF25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0009-2797(86)80052-7","article-title":"Mental induced DNA damage and repair in human diploid fibroblasts and Chinese hamster ovary cells","volume":"59","author":"Hamilton-Kock","year":"1986","journal-title":"Chem.\u2013Biol. Interact."},{"key":"10.1006\/taap.1999.8652_RF26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4049\/jimmunol.156.1.42","article-title":"Induction of apoptosis in NK cells by monocyte-derived reactive oxygen metabolites","volume":"156","author":"Hansson","year":"1996","journal-title":"J. Immunol."},{"key":"10.1006\/taap.1999.8652_RF27","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1006\/cimm.1997.1160","article-title":"In vivo the environmental pollutants lead and mercury induce oligoclonal T cell responses skewed toward type-2 reactivities","volume":"179","author":"Heo","year":"1997","journal-title":"Cell. Immunol."},{"key":"10.1006\/taap.1999.8652_RF28","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1038\/sj.onc.1201324","article-title":"The apoptosis-necrosis paradox. Apoptogenic proteases activated after mitochondrial permeability transition determine the mode of cell death","volume":"15","author":"Hirsch","year":"1997","journal-title":"Oncogene"},{"key":"10.1006\/taap.1999.8652_RF29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1146\/annurev.pa.36.040196.001023","article-title":"Molecular mechanisms of toxicant-induced immunosuppression: Role of second messengers","volume":"36","author":"Holsapple","year":"1996","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1006\/taap.1999.8652_RF30","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1159\/000186965","article-title":"Gluthione monoethyl ester moderates mercuric chloride-induced acute renal failure","volume":"61","author":"Houser","year":"1992","journal-title":"Nephron"},{"key":"10.1006\/taap.1999.8652_RF31","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1046\/j.1365-2249.1997.d01-903.x","article-title":"Thiol compounds inhibit mercury-induced immunological and immunopathological alterations in susceptible mice","volume":"107","author":"Hu","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/taap.1999.8652_RF32","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/374814a0","article-title":"Programmed cell death and Bcl-2 protection in very low oxygen","volume":"374","author":"Jacobson","year":"1995","journal-title":"Nature"},{"key":"10.1006\/taap.1999.8652_RF33","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0300-483X(94)02960-3","article-title":"Effects of buthionine sulfoximine (BSO) on mercury distribution after Hgo","volume":"98","author":"Kim","year":"1995","journal-title":"Toxicology"},{"key":"10.1006\/taap.1999.8652_RF34","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1126\/science.275.5303.1132","article-title":"The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis","volume":"275","author":"Kluck","year":"1997","journal-title":"Science"},{"key":"10.1006\/taap.1999.8652_RF35","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/nm0697-614","article-title":"The proto-oncogene Bcl-2 and its role in regulating apoptosis","volume":"3","author":"Kroemer","year":"1997","journal-title":"Nature Med."},{"key":"10.1006\/taap.1999.8652_RF36","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1096\/fasebj.9.13.7557017","article-title":"The biochemistry of programmed cell death","volume":"9","author":"Kroemer","year":"1995","journal-title":"FASEB J."},{"key":"10.1006\/taap.1999.8652_RF37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0167-5699(97)80014-X","article-title":"Mitochondrial control of apoptosis","volume":"18","author":"Kroemer","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1006\/taap.1999.8652_RF38","first-page":"17","article-title":"Approaches to the evaluation of chemical-induced immunotoxicity","volume":"103","author":"Krzystyniak","year":"1995","journal-title":"Environ. Health Perspect."},{"key":"10.1006\/taap.1999.8652_RF39","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1177\/00220345970760071001","article-title":"Exposure to mercury vapor and impact on health in the dental profession in Sweden","volume":"76","author":"Langworth","year":"1997","journal-title":"J. Dent. Res."},{"key":"10.1006\/taap.1999.8652_RF40","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0041-008X(81)90241-6","article-title":"Heavy metal modulation of lymphocyte activation. I. In vitro effects of heavy metals on primary humoral immune responses","volume":"57","author":"Lawrence","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8652_RF41","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1006\/bbrc.1996.5897","article-title":"Reactive oxygen species participate in peroxynitrite-induced apoptosis in HL-60 cells","volume":"230","author":"Lin","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.1999.8652_RF42","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1046\/j.1365-2249.1997.4531470.x","article-title":"In vitro effects of mercuric chloride (HgCl2","volume":"110","author":"Loftenius","year":"1997","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/taap.1999.8652_RF43","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0300-483X(94)02964-V","article-title":"The dental amalgam mercury controversy\u2014inorganic mercury and the CNS; Genetic linkage of mercury and antibiotic resistances in intestinal bacteria","volume":"97","author":"Lorscheider","year":"1995","journal-title":"Toxicology"},{"key":"10.1006\/taap.1999.8652_RF44","doi-asserted-by":"crossref","first-page":"4830","DOI":"10.4049\/jimmunol.157.11.4830","article-title":"Mitochondrial permeability transition triggers lymphocyte apoptosis","volume":"157","author":"Marchetti","year":"1996","journal-title":"J. Immunol."},{"key":"10.1006\/taap.1999.8652_RF45","doi-asserted-by":"crossref","first-page":"16260","DOI":"10.1074\/jbc.271.27.16260","article-title":"Events in apoptosis. Acidification is downstream of protease activation and Bcl-2 protection","volume":"271","author":"Meisenholder","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.1999.8652_RF46","first-page":"401","article-title":"Mercury-induced autoimmune glomerulonephritis in inbred rats. I. Kinetics and species specificity of autoimmune responses","volume":"4","author":"Michaelson","year":"1985","journal-title":"Surv. Synth. Path. Res."},{"key":"10.1006\/taap.1999.8652_RF47","doi-asserted-by":"crossref","unstructured":"O, I. Datar, S. Koch, C. J. Shapiro, I. M. Shenker, B. J. Mercuric compounds inhibit human monocyte function by inducing apoptosis: Evidence for formation of reactive oxygen species, development of mitochondrial membrane permeability transition and loss of reductive reserve, Toxicol. 124, 211, 224","DOI":"10.1016\/S0300-483X(97)00153-4"},{"key":"10.1006\/taap.1999.8652_RF48","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0109-5641(95)80028-X","article-title":"Short-term changes in lymphocytes after placement of silver amalgam restorations in healthy subjects","volume":"11","author":"Osorio","year":"1995","journal-title":"Dent. Mater."},{"key":"10.1006\/taap.1999.8652_RF49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0014-5793(96)00988-X","article-title":"Mitochondria and programmed cell death: back to the future","volume":"396","author":"Petit","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1006\/taap.1999.8652_RF50","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3109\/01480549009032288","article-title":"Serum immunoglobulin levels in monkeys treated with methylmercury","volume":"13","author":"Petruccioli","year":"1990","journal-title":"Drug Chem. Toxicol."},{"key":"10.1006\/taap.1999.8652_RF51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.124.1.1","article-title":"Bcl-2 and the regulation of programmed cell death","volume":"124","author":"Reed","year":"1994","journal-title":"J. Cell Biol."},{"key":"10.1006\/taap.1999.8652_RF52","doi-asserted-by":"crossref","first-page":"4480","DOI":"10.1021\/bi00232a015","article-title":"J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential","volume":"30","author":"Reers","year":"1991","journal-title":"Biochemistry"},{"key":"10.1006\/taap.1999.8652_RF53","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/(SICI)1097-0320(19961201)25:4<349::AID-CYTO6>3.0.CO;2-8","article-title":"Detection of apoptosis by flow cytometry of cells simultaneously stained for intracellular pH (carboxy SNARF-1) and membrane permeability (Hoechst 33342)","volume":"25","author":"Reynolds","year":"1996","journal-title":"Cytometry"},{"key":"10.1006\/taap.1999.8652_RF54","first-page":"6110","article-title":"Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistancein vitroin vivo","volume":"46","author":"Rice","year":"1986","journal-title":"Cancer Res."},{"key":"10.1006\/taap.1999.8652_RF55","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1002\/jlb.47.5.440","article-title":"Flow cytometric analysis of respiratory burst activity in phagocytres with hydroethidine and 2\u2032,7\u2032-dichlorofluorescin","volume":"47","author":"Rothe","year":"1990","journal-title":"J. Leuk. Bio."},{"key":"10.1006\/taap.1999.8652_RF56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jlb.55.2.221","article-title":"Inhibition of activation-induced death in T cell hybridomas by thiol antioxidants: Oxidative stress as a mediator of apoptosis","volume":"55","author":"Sandstrom","year":"1994","journal-title":"J. Leukoc. Biol."},{"key":"10.1006\/taap.1999.8652_RF57","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00364205","article-title":"Polyclonal IgE increase after HgCl2","volume":"20","author":"Sapin","year":"1984","journal-title":"Immunogenetics"},{"key":"10.1006\/taap.1999.8652_RF58","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/cyto.990150104","article-title":"Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry","volume":"15","author":"Schmid","year":"1994","journal-title":"Cytometry"},{"key":"10.1006\/taap.1999.8652_RF59","doi-asserted-by":"crossref","first-page":"555","DOI":"10.3109\/08923979209005411","article-title":"Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. II. Alterations in cell viability","volume":"14","author":"Shenker","year":"1992","journal-title":"Immunopharm. Immunotox."},{"key":"10.1006\/taap.1999.8652_RF60","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/08923979309066936","article-title":"Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. III. Alterations in B-cell function and viability","volume":"15","author":"Shenker","year":"1993","journal-title":"Immunopharm. Immunotox."},{"key":"10.1006\/taap.1999.8652_RF61","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1006\/taap.1997.8111","article-title":"Induction of apoptosis in human T-cells by organomercuric compounds: A flow cytometric analysis","volume":"143","author":"Shenker","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8652_RF62","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/08923979309025999","article-title":"Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. IV. Alterations in cellular glutathione content","volume":"15","author":"Shenker","year":"1993","journal-title":"Immunopharm. Immunotox."},{"key":"10.1006\/taap.1999.8652_RF63","doi-asserted-by":"crossref","first-page":"539","DOI":"10.3109\/08923979209005410","article-title":"Immunotoxic effects of mercuric compounds on human lymphocytes and monocytes. I. Suppression of T-cell activation","volume":"14","author":"Shenker","year":"1992","journal-title":"Immunopharm. Immunotox."},{"key":"10.1006\/taap.1999.8652_RF64","first-page":"36","volume":"164","author":"Shenker","year":"1995","journal-title":"Actinobacillus actinomycetemcomitans. Cell. Immunol."},{"key":"10.1006\/taap.1999.8652_RF65","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1006\/enrs.1997.3816","article-title":"Low-level methylmercury exposure causes human T-cells to undergo apoptosis: Evidence of mitochondrial dysfunction","volume":"77","author":"Shenker","year":"1998","journal-title":"Environ. Res."},{"key":"10.1006\/taap.1999.8652_RF66","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0014-5793(96)00989-1","article-title":"Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide-producing mitochondria and cell","volume":"397","author":"Skulachev","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1006\/taap.1999.8652_RF67","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1136\/oem.54.6.437","article-title":"Minimal immunological effects on workers with prolonged low exposure to inorganic mercury","volume":"54","author":"Soleo","year":"1997","journal-title":"Occupation. Environ. Med."},{"key":"10.1006\/taap.1999.8652_RF68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF01540970","article-title":"Mercury-specific lymphocytes: An indication of mercury allergy in man","volume":"16","author":"Stejskal","year":"1996","journal-title":"J. Clin. Immunol."},{"key":"10.1006\/taap.1999.8652_RF69","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0300-483X(96)03486-5","article-title":"Immunomodulating effects after perinatal exposure to methylmercury in mice","volume":"114","author":"Thuvander","year":"1996","journal-title":"Toxicology"},{"key":"10.1006\/taap.1999.8652_RF70","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1006\/taap.1999.8652_RF71","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-4274(97)84688-7","article-title":"Early detection of immunotoxicity: From animal studies to human biomonitoring","volume":"77","author":"Van Loveren","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1006\/taap.1999.8652_RF72","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/faat.1997.2320","article-title":"Symposium overview: Mitochondria-mediated cell injury","volume":"38","author":"Wallace","year":"1997","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1006\/taap.1999.8652_RF73","doi-asserted-by":"crossref","first-page":"18107","DOI":"10.1074\/jbc.271.30.18107","article-title":"Metabolic stress opens K+ channels in hepatoma cells through a Ca2+- and protein kinase calpha-dependent mechanism","volume":"271","author":"Wang","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.1999.8652_RF74","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1600-0714.1994.tb00441.x","article-title":"Contact stomatitis to mercury associated with spontaneous mononuclear cell infiltrates in Brown Norway (BN) rats with HgCl2","volume":"23","author":"Warfvinge","year":"1994","journal-title":"J. Oral Pathol. Med."},{"key":"10.1006\/taap.1999.8652_RF75","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0014-5793(94)00920-1","article-title":"A role for metals and free radicals in the induction of apoptosis in thymocytes","volume":"352","author":"Wolfe","year":"1994","journal-title":"FEBS Lett."},{"key":"10.1006\/taap.1999.8652_RF76","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1007\/s002040050104","article-title":"Acute effects of methylmercury on hepatic and renal glutathione metabolisms in mice","volume":"68","author":"Yasutake","year":"1994","journal-title":"Arch. Toxicol."},{"key":"10.1006\/taap.1999.8652_RF77","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1084\/jem.182.2.367","article-title":"Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death","volume":"182","author":"Zamzami","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1006\/taap.1999.8652_RF78","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1182\/blood.V89.2.630","article-title":"Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions","volume":"89","author":"Zhou","year":"1997","journal-title":"Blood"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X99986520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X99986520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T20:35:18Z","timestamp":1758573318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X99986520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,5]]}},"alternative-id":["S0041008X99986520"],"URL":"https:\/\/doi.org\/10.1006\/taap.1999.8652","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[1999,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Induction of Apoptosis in Human T-Cells by Methyl Mercury: Temporal Relationship between Mitochondrial Dysfunction and Loss of Reductive Reserve","name":"articletitle","label":"Article Title"},{"value":"Toxicology and Applied Pharmacology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/taap.1999.8652","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1999 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}