{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T19:47:58Z","timestamp":1790970478218,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1006\/taap.1999.8848","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:01:25Z","timestamp":1032372085000},"page":"1-8","source":"Crossref","is-referenced-by-count":56,"title":["The Role of Voltage-Gated Chloride Channels in Type II Pyrethroid Insecticide Poisoning"],"prefix":"10.1006","volume":"163","author":[{"given":"P.J.","family":"Forshaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Lister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"Ray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.1999.8848_RF1","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1016\/0006-2952(85)90550-7","article-title":"Binding of GABA receptor channel drugs to a putative voltage-dependent chloride channel in Torpedo electric organ","volume":"34","author":"Abalis","year":"1985","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1113\/jphysiol.1976.sp011410","article-title":"Action potentials reconstructed in normal and myotonic muscle fibres","volume":"258","author":"Adrian","year":"1976","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1006\/taap.1999.8848_RF3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0041-008X(91)90242-7","article-title":"Protection against pyrethroid toxicity in rats with mephenesin","volume":"60","author":"Bradbury","year":"1981","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0028-3908(83)90139-9","article-title":"The action of mephenesin and other agents on the effects produced by two neurotoxic pyrethroids on the intact and spinal rat","volume":"22","author":"Bradbury","year":"1983","journal-title":"Neuropharmacology"},{"key":"10.1006\/taap.1999.8848_RF5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1113\/jphysiol.1986.sp016280","article-title":"Stabilization of sodium channel states by deltamethrin in mouse neuroblastoma cells","volume":"380","author":"Chinn","year":"1986","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1006\/taap.1999.8848_RF6","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1469-7793.1998.665bv.x","article-title":"Characterization of the hyperpolarization-activated chloride current in dissociated rat sympethetic neurons","volume":"506","author":"Clark","year":"1998","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1006\/taap.1999.8848_RF7","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/0006-8993(80)91344-X","article-title":"Regional changes in brain glucose utilization in rats given a pyrethroid insecticide","volume":"194","author":"Cremer","year":"1980","journal-title":"Brain Res."},{"key":"10.1006\/taap.1999.8848_RF8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0014-2999(86)90499-1","article-title":"PK11195 antagonism of pyrethroid-induced proconvulsant activity","volume":"120","author":"Devaud","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF9","first-page":"14","article-title":"Involvement of peripheral-type benzodiazepine receptors in the proconvulsant actions of pyrethroid insecticides","volume":"247","author":"Devaud","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.1999.8848_RF10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ijc.2910630220","article-title":"Decreased biotolerability for ivermectin and cyclosporin-a in mice exposed to potent P-glycoprotein inhibitors","volume":"63","author":"Didier","year":"1995","journal-title":"Int. J. Cancer"},{"key":"10.1006\/taap.1999.8848_RF11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1476-5381.1985.tb08874.x","article-title":"Actions of dihydroavermectin B, on insect muscle","volume":"85","author":"Duce","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0028-3908(90)90086-7","article-title":"A novel action of deltamethrin on membrane resistance in mammalian skeletal muscle and non-myelinated nerve fibres","volume":"29","author":"Forshaw","year":"1990","journal-title":"Neuropharmacology"},{"key":"10.1006\/taap.1999.8848_RF13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0028-3908(93)90089-L","article-title":"Inhibition of a neuronal voltage-dependent chloride channel by the type II pyrethroid, deltamethrin","volume":"32","author":"Forshaw","year":"1993","journal-title":"Neuropharmacology"},{"key":"10.1006\/taap.1999.8848_RF14","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1097\/00000542-199004000-00012","article-title":"Molecular actions of pentobarbital isomers on sodium channels from human brain cortex","volume":"72","author":"Frenkel","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1006\/taap.1999.8848_RF15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0041-008X(82)90294-0","article-title":"Pyrethroid toxicology: Protective effects of diazepam and phenobarbital in the mouse and cockroach","volume":"66","author":"Gammon","year":"1982","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/BF00334635","article-title":"Clinical manifestations and diagnosis of acute pyrethroid poisoning","volume":"63","author":"He","year":"1989","journal-title":"Arch. Toxicol."},{"key":"10.1006\/taap.1999.8848_RF17","first-page":"261","article-title":"Avermectin B1a binds to high- and low-affinity sites with dual effects on the \u03b3-aminobutyric acid-gated chloride channel of cultured cerebellar granule neurons","volume":"281","author":"Huang","year":"1997","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.1999.8848_RF18","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/s004240050847","article-title":"The CLC chloride channel family","volume":"437","author":"Jentsch","year":"1999","journal-title":"Pfluegers Arch. Eur. J. Physiol."},{"key":"10.1006\/taap.1999.8848_RF19","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0041-008X(90)90325-O","article-title":"Characteristics of the prolonged inhibition produced by a range of pyrethroids in the rat hippocampus","volume":"103","author":"Joy","year":"1990","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF20","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1001\/archderm.1984.01650420054015","article-title":"Paresthesia from cutaneous exposure to a synthetic pyrethroid insecticide","volume":"120","author":"Knox","year":"1984","journal-title":"Arch. Dermatol."},{"key":"10.1006\/taap.1999.8848_RF21","first-page":"1","article-title":"Transient facial sensory symptoms following exposure to synthetic pyrethroids: A clinical and electrophysiological assessment","volume":"2","author":"Le Quesne","year":"1980","journal-title":"Neurotoxicology"},{"key":"10.1006\/taap.1999.8848_RF22","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0041-008X(88)90158-5","article-title":"Action of polychloro-cycloalkane insecticides on binding of [35S]t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site","volume":"95","author":"Matsumoto","year":"1988","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF23","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1096\/fasebj.2.13.2458984","article-title":"Lindane but not deltamethrin blocks a component of GABA-activated chloride channels","volume":"2","author":"Ogata","year":"1988","journal-title":"FASEB J."},{"key":"10.1006\/taap.1999.8848_RF24","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1523\/JNEUROSCI.02-12-01812.1982","article-title":"Chloride-dependent enhancement by barbiturates of GABA receptor binding","volume":"2","author":"Olsen","year":"1982","journal-title":"J. Neurosci."},{"key":"10.1006\/taap.1999.8848_RF25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/pest.1993.1077","article-title":"Actions of avermectin analogues on \u03b3-aminobutyric acid (GABA)-sensitive and GABA-insensitive chloride channels in mouse brain","volume":"47","author":"Payne","year":"1993","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1006\/taap.1999.8848_RF26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0048-3575(88)90002-8","article-title":"Action of pyrethroids on GABAA receptor function","volume":"32","author":"Ramadan","year":"1988","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1006\/taap.1999.8848_RF27","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0048-3575(79)90039-7","article-title":"The action of decamethrin (a synthetic pyrethroid) on the rat","volume":"10","author":"Ray","year":"1979","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1006\/taap.1999.8848_RF28","first-page":"755","article-title":"Actions of pyrethroid insecticides on voltage-gated chloride channels in neuroblastoma cells","volume":"18","author":"Ray","year":"1997","journal-title":"Neurotoxicology"},{"key":"10.1006\/taap.1999.8848_RF29","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1113\/jphysiol.1996.sp021784","article-title":"Direct activation of GABAA receptors by barbiturates in cultured rat hippocampal neurones","volume":"497","author":"Rho","year":"1996","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1006\/taap.1999.8848_RF30","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1172\/JCI118699","article-title":"P-glycoprotein in the blood-brain barrier of mice influences the brain penetration and pharmacological activity of many drugs","volume":"97","author":"Schinkel","year":"1996","journal-title":"J. Clin. Invest."},{"key":"10.1006\/taap.1999.8848_RF31","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1007\/BF00167239","article-title":"Activation of Cl\u2212 channels by avermectin in rat culture hippocampal neurones","volume":"348","author":"Schonrock","year":"1993","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF32","first-page":"749","article-title":"Effect of avermectin B1a on chick neuronal gamma-aminobutyrate receptor channels expressed in Xenopus oocytes","volume":"32","author":"Sigel","year":"1987","journal-title":"Mol. Pharmacol."},{"key":"10.1006\/taap.1999.8848_RF33","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1523\/JNEUROSCI.15-05-04057.1995","article-title":"Differential expression of an inwardly rectifying chloride conductance in rat brain neurons: A potential mechanism for cell-specific modulation of postsynaptic inhibition","volume":"15","author":"Smith","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1006\/taap.1999.8848_RF34","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.7638623","article-title":"Ionic mechanisms of neuronal excitation by inhibitory GABAA receptors","volume":"269","author":"Staley","year":"1995","journal-title":"Science"},{"key":"10.1006\/taap.1999.8848_RF35","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF00293813","article-title":"Structure\u2013activity relationships of some pyrethroids in rats","volume":"45","author":"Verschoyle","year":"1980","journal-title":"Arch. Toxicol."},{"key":"10.1006\/taap.1999.8848_RF36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0048-3575(88)90062-4","article-title":"Classification of the actions of ten pyrethroid insecticides in the rat using the trigeminal reflex and skeletal muscle as test systems","volume":"30","author":"Wright","year":"1988","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1006\/taap.1999.8848_RF37","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0006-2952(97)00433-4","article-title":"Characterization of central- and peripheral-type benzodiazepine receptors in rat salivary glands","volume":"55","author":"Yamagishi","year":"1998","journal-title":"Biochem. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X99988488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X99988488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T05:16:04Z","timestamp":1576559764000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X99988488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0041008X99988488"],"URL":"https:\/\/doi.org\/10.1006\/taap.1999.8848","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}