{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T21:00:44Z","timestamp":1769806844217,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,2,1]],"date-time":"2000-02-01T00:00:00Z","timestamp":949363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2000,2]]},"DOI":"10.1006\/taap.1999.8859","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"17-25","source":"Crossref","is-referenced-by-count":33,"title":["Modulation of Transcription Factor AP-1 Activity in Murine EL-4 Thymoma Cells by Vomitoxin (Deoxynivalenol)"],"prefix":"10.1006","volume":"163","author":[{"given":"Shiguang","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanli","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gi-Hyeok","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James J.","family":"Pestka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.1999.8859_RF1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1128\/AEM.57.3.672-677.1991","article-title":"Immunochemical assessment of mycotoxins in 1989 grain foods: Evidence for deoxynivalenol (vomitoxin) contamination","volume":"57","author":"Abouzied","year":"1991","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1006\/taap.1999.8859_RF2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60740-3","article-title":"NF-IL6 and NF- 95 B in cytokine gene regulation","volume":"65","author":"Akira","year":"1997","journal-title":"Adv. Immunol."},{"key":"10.1006\/taap.1999.8859_RF3","first-page":"129","article-title":"The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation","volume":"1072","author":"Angel","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.1999.8859_RF4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0278-6915(95)00012-Q","article-title":"Effects of vomitoxin (deoxynivalenol) and cycloheximide on IL-2, 4, 5 and 6 secretion and mRNA levels in murine CD4+ cells","volume":"33","author":"Azcona-Olivera","year":"1995","journal-title":"Food Chem. Toxicol."},{"key":"10.1006\/taap.1999.8859_RF5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1006\/taap.1995.1132","article-title":"Induction of cytokine mRNAs in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Relationship to toxin distribution and protein synthesis inhibition","volume":"133","author":"Azcona-Olivera","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF6","series-title":"Mycotoxins","first-page":"192","article-title":"Trichothecenes","author":"Betina","year":"1989"},{"key":"10.1006\/taap.1999.8859_RF7","first-page":"37","article-title":"Outbreak of trichothecene mycotoxicosis associated with consumption of mould-damaged wheat products in Kashmir Valley, India","volume":"53","author":"Bhat","year":"1989","journal-title":"Lancet"},{"key":"10.1006\/taap.1999.8859_RF8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1165\/ajrcmb.17.1.f132","article-title":"The role of nuclear factor-kappa B in cytokine gene regulation","volume":"17","author":"Blackwell","year":"1997","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1006\/taap.1999.8859_RF9","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/0041-008X(91)90098-Y","article-title":"Dietary exposure to trichothecene vomitoxin (deoxynivalenol) stimulates terminal differentiation of Peyer's patch B cells to IgA secreting plasma cells","volume":"108","author":"Bondy","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/faat.1993.1005","article-title":"Persistent dysregulation of IgA production and IgA nephropathy in the B6C3F1 mouse following withdrawal of dietary vomitoxin (deoxynivalenol)","volume":"20","author":"Dong","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1006\/taap.1999.8859_RF11","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1006\/taap.1994.1163","article-title":"Elevated gene expression and production of interleukins 2, 4, 5, and 6 during exposure to vomitoxin (deoxynivalenol) and cycloheximide in the EL-4 thymoma","volume":"127","author":"Dong","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jlb.63.2.139","article-title":"Transcriptional regulation in the immune system: all roads to AP-1","volume":"63","author":"Foletta","year":"1997","journal-title":"J. Leukocyte Biol."},{"key":"10.1006\/taap.1999.8859_RF13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1210\/endo.137.1.8536642","article-title":"Acute nuclear actions of growth hormone (GH): Cycloheximide inhibits inducible activator protein-1 activity, but does not block GH-regulated signal transducer and activator of transcription activation or gene expression","volume":"137","author":"Gronowski","year":"1996","journal-title":"Endocrinology"},{"key":"10.1006\/taap.1999.8859_RF14","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1042\/bj3140547","article-title":"Induction of the mammalian stress response gene GADD153 by oxidative stress: Role of AP-1 element","volume":"314","author":"Guyton","year":"1996","journal-title":"Biochem. J."},{"key":"10.1006\/taap.1999.8859_RF15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/3540551921_7","article-title":"DNA damage-induced gene expression: signal transduction and relation to growth factor signaling","volume":"119","author":"Herrlich P.","year":"1992","journal-title":"Rev. Physiol. Biochem. Pharmcol."},{"key":"10.1006\/taap.1999.8859_RF16","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1101\/gad.7.11.2135","article-title":"Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain","volume":"7","author":"Hibi","year":"1993","journal-title":"Genes Dev."},{"key":"10.1006\/taap.1999.8859_RF17","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1128\/MCB.17.6.3373","article-title":"Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the alpha-sarcin\/ricin loop in the 28S rRNA","volume":"17","author":"Iordanov","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1006\/taap.1999.8859_RF18","doi-asserted-by":"crossref","first-page":"16483","DOI":"10.1074\/jbc.270.28.16483","article-title":"The regulation of AP-1 activity by mitogen-activated protein kinases","volume":"270","author":"Karin","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.1999.8859_RF19","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","article-title":"AP-1 function and regulation","volume":"9","author":"Karin","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1006\/taap.1999.8859_RF20","first-page":"2373","article-title":"Photodynamic therapy induces expression of interleukin 6 by activation of AP-1 but not NF-kappa B DNA binding","volume":"55","author":"Kick","year":"1995","journal-title":"Cancer Res."},{"key":"10.1006\/taap.1999.8859_RF21","series-title":"Casarett & Doull's Toxicology The Basic Science of Poisons","first-page":"909","article-title":"Food toxicology","author":"Kotsonis","year":"1996"},{"key":"10.1006\/taap.1999.8859_RF22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0022-1759(93)90379-L","article-title":"Assessment of lymphokine profiles in activated lymphocytes by semiquantitative PCR","volume":"162","author":"Kramnik","year":"1993","journal-title":"J. Immunol. Methods"},{"key":"10.1006\/taap.1999.8859_RF23","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/369156a0","article-title":"The stress-activated protein kinase subfamily of c-Jun kinases","volume":"369","author":"Kyriakis","year":"1994","journal-title":"Nature"},{"key":"10.1006\/taap.1999.8859_RF24","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1006\/taap.1997.8279","article-title":"Superinduction of IL-2 gene expression by vomitoxin (deoxynivalenol) involves increased mRNA stability","volume":"147","author":"Li","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/excr.1996.0064","article-title":"Effects of immortalization upon the induction of matrix metalloproteinases in rabbit synovial fibroblasts","volume":"223","author":"Lin","year":"1996","journal-title":"Exp. Cell Res."},{"key":"10.1006\/taap.1999.8859_RF26","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0006-2952(96)00390-5","article-title":"Analysis of rat cytochrome P450 isoenzyme expression using semi-quantitative reverse transcriptase-ploymerase chain reaction (RT\u2013PCR)","volume":"52","author":"Morris","year":"1996","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF27","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.275.5298.400","article-title":"Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases","volume":"275","author":"Musti","year":"1997","journal-title":"Science"},{"key":"10.1006\/taap.1999.8859_RF28","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.4049\/jimmunol.157.3.1139","article-title":"Identification of a novel regulatory region critical for expression of the rants chemokine in activated T lymphocytes","volume":"157","author":"Nelson","year":"1996","journal-title":"J. Immunol."},{"key":"10.1006\/taap.1999.8859_RF29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0300-483X(95)03147-8","article-title":"Effects of trichothecene structure on cytokine secretion and gene expression in murine CD4+ T cells","volume":"104","author":"Ouyang","year":"1995","journal-title":"Toxicology"},{"key":"10.1006\/taap.1999.8859_RF30","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/taap.1996.0131","article-title":"Vomitoxin-mediated IL-2, IL-4, and IL-5 superinduction in murine CD4+ T cells stimulated with phorbol ester and calcium ionophore: Relation to kinetics of proliferation","volume":"138","author":"Ouyang","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF31","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/taap.1996.0228","article-title":"Effect of vomitoxin (deoxynivalenol) on transcription factor NF-\u03baB\/Rel binding activity in murine EL-4 thymoma and primary CD4+ T cells","volume":"140","author":"Ouyang","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0278-6915(89)90141-5","article-title":"Dysregulation of IgA production and IgA nephropathy induced by the trichothecene vomitoxin","volume":"27","author":"Pestka","year":"1989","journal-title":"Food Chem. Toxicol."},{"key":"10.1006\/taap.1999.8859_RF33","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4049\/jimmunol.153.1.343","article-title":"Superinduction of cytokine gene transcription by ciprofloxacin","volume":"153","author":"Riesbeck","year":"1994","journal-title":"J. Immunol."},{"key":"10.1006\/taap.1999.8859_RF34","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1042\/bj3300429","article-title":"Enhanced AP-1 and NF-kappa B activities and stability of interleukin 8 (IL-8) transcripts are implicated in IL-8 mRNA superinduction in lung epithelial H292 cells","volume":"330","author":"Roger","year":"1998","journal-title":"Biochem. J."},{"key":"10.1006\/taap.1999.8859_RF35","first-page":"2301","article-title":"Okadaic acid stimulated TRE binding activity in a papilloma producing mouse keratinocyte cell line involves increased AP-1 expression","volume":"12","author":"Rosenberger","year":"1996","journal-title":"Oncogene"},{"key":"10.1006\/taap.1999.8859_RF36","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/0092-8674(94)90272-0","article-title":"Involvement of growth factor receptors in the mammalian UVC response","volume":"78","author":"Sachsenmaier","year":"1994","journal-title":"Cell"},{"key":"10.1006\/taap.1999.8859_RF37","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s001090050075","article-title":"Transcription factors: Important tools and targets for molecular medicine","volume":"74","author":"Scheidereit","year":"1996","journal-title":"J. Mol. Med."},{"key":"10.1006\/taap.1999.8859_RF38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0167-4781(95)00112-T","article-title":"The architecture of the interleukin-2 promoter: A reflection of T lymphocyte activation","volume":"1263","author":"Serfling","year":"1995","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.1999.8859_RF39","first-page":"661","article-title":"Trichothecenes in grains","volume":"35","author":"Scott","year":"1990","journal-title":"Cereal Foods World"},{"key":"10.1006\/taap.1999.8859_RF40","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1084\/jem.184.5.1663","article-title":"c-Rel regulation of IL-2 gene expression may be mediated through activation of AP-1","volume":"184","author":"Shapiro","year":"1996","journal-title":"J. Exp. Med."},{"key":"10.1006\/taap.1999.8859_RF41","doi-asserted-by":"crossref","first-page":"13985","DOI":"10.1074\/jbc.274.20.13985","article-title":"Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis","volume":"274","author":"Shifrin","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.1999.8859_RF42","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/eji.1830230913","article-title":"Activator protein-1 (AP-1) is stimulated by microbial superantigens in human monocytic cells","volume":"23","author":"Trede","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/taap.1999.8859_RF43","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0300-483X(97)00087-5","article-title":"Potential role for IL-5 and IL-6 in enhanced IgA secretion by Peyer's patch cells isolated from mice acutely exposed to vomitoxin","volume":"122","author":"Yan","year":"1997","journal-title":"Toxicology"},{"key":"10.1006\/taap.1999.8859_RF44","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1006\/taap.1997.8326","article-title":"Role of macrophage in elevated IgA and IL-6 production by Peyer's patch cultures following acute oral vomitoxin exposure","volume":"148","author":"Yan","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.1999.8859_RF45","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1006\/taap.1997.8132","article-title":"Differential cytokine mRNA expression in mice after oral exposure to the trichothecene vomitoxin (deoxynivalenol): Dose response and time course","volume":"144","author":"Zhou","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X99988592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X99988592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T16:45:14Z","timestamp":1680626714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X99988592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,2]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,2]]}},"alternative-id":["S0041008X99988592"],"URL":"https:\/\/doi.org\/10.1006\/taap.1999.8859","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,2]]}}}