{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:55:44Z","timestamp":1758632144996},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2000,5]]},"DOI":"10.1006\/taap.2000.8924","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"27-36","source":"Crossref","is-referenced-by-count":7,"title":["The Role of Cholinergic and Noncholinergic Mechanisms in the Cardiorespiratory Failure Produced by N-Methylcarbamate Cholinesterase Inhibitors in Rabbits"],"prefix":"10.1006","volume":"165","author":[{"given":"Haruko","family":"Futagawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Kakinuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2000.8924_RF1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1113\/jphysiol.1973.sp010405","article-title":"The maximum derivatives of left ventricular pressure and transverse internal diameter as indices of the inotropic state of the left ventricle in conscious dogs","volume":"235","author":"Barnes","year":"1973","journal-title":"J. Physiol."},{"key":"10.1006\/taap.2000.8924_RF2","first-page":"R932","article-title":"Neurons of C1 area mediate cardiovascular responses initiated from ventral medullary surface","volume":"250","author":"Benarroch","year":"1986","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2000.8924_RF3","first-page":"211","article-title":"Central nervous respiratory depressants\u2014Control-systems approach to respiratory depression","volume":"3","author":"Borison","year":"1977","journal-title":"Pharmacol. Ther. Part B"},{"key":"10.1006\/taap.2000.8924_RF4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1146\/annurev.pa.22.040182.002013","article-title":"Cardiovascular control by cholinergic mechanisms in the central nervous system","volume":"22","author":"Brezenoff","year":"1982","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1006\/taap.2000.8924_RF5","first-page":"65","article-title":"Drugs acting on central cholinergic mechanisms and affecting respiration","volume":"3","author":"Brimblecombe","year":"1977","journal-title":"Pharmacol. Ther. Part B"},{"key":"10.1006\/taap.2000.8924_RF6","first-page":"179","article-title":"The role of central cholinergic neurons in the regulation of blood pressure and in experimental hypertension","volume":"48","author":"Buccafusco","year":"1996","journal-title":"Pharmacol. Rev."},{"key":"10.1006\/taap.2000.8924_RF7","first-page":"466","article-title":"The failure of respiration in death by anticholinesterase poisoning","volume":"8","author":"De Candole","year":"1953","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/taap.2000.8924_RF8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2000.8924_RF9","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev.ph.50.030188.003113","article-title":"Central coordination of respiratory and cardiovascular control in mammals","volume":"50","author":"Feldman","year":"1988","journal-title":"Annu. Rev. Physiol."},{"key":"10.1006\/taap.2000.8924_RF10","series-title":"Probit Analysis\u2014A Statistical Treatment of the Sigmoid Response Curve","author":"Finney","year":"1952"},{"key":"10.1006\/taap.2000.8924_RF11","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1006\/faat.1993.1028","article-title":"Modulation of muscarinic receptors and acetylcholinesterase activity in lymphocytes and in brain areas following repeated organophosphate exposure in rats","volume":"20","author":"Fitzgerald","year":"1993","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1006\/taap.2000.8924_RF12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0300-483X(96)03568-8","article-title":"Cardiovascular collapse through non-cholinergic mechanism after intravenous injection of N-methylcarbamate insecticide in rabbits","volume":"117","author":"Futagawa","year":"1997","journal-title":"Toxicology"},{"key":"10.1006\/taap.2000.8924_RF13","first-page":"765","article-title":"Cardiorespiratory effects produced by activation of cholinergic muscarinic receptors on the ventral surface of the medulla","volume":"247","author":"Gillis","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2000.8924_RF14","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1523\/JNEUROSCI.09-03-00923.1989","article-title":"Cholinergic regulation of arterial pressure by the C1 area of the rostral ventrolateral medulla","volume":"9","author":"Giuliano","year":"1989","journal-title":"J. Neurosci."},{"key":"10.1006\/taap.2000.8924_RF15","series-title":"Central Neural Mechanisms in Cardiovascular Regulation","first-page":"226","article-title":"Respiratory-sympathetic integration in the medulla oblongata","author":"Guyenet","year":"1991"},{"key":"10.1006\/taap.2000.8924_RF16","first-page":"157","article-title":"Calcium movements, distribution, and functions in smooth muscle","volume":"49","author":"Karaki","year":"1997","journal-title":"Pharmacol. Rev."},{"key":"10.1006\/taap.2000.8924_RF17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0361-9230(96)00256-0","article-title":"Cholinergic mechanisms responsible for blood pressure regulation on sympathoexcitatory neurons in the rostral ventrolateral medulla of the rat","volume":"42","author":"Kubo","year":"1997","journal-title":"Brain. Res. Bull."},{"key":"10.1006\/taap.2000.8924_RF18","series-title":"Carbamate Insecticides: Chemistry, Biochemistry, and Toxicology","first-page":"1","article-title":"Development and use","author":"Kuhr","year":"1976"},{"key":"10.1006\/taap.2000.8924_RF19","series-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","first-page":"105","article-title":"Neurotransmission: The autonomic and somatic motor nervous systems","author":"Lefkowitz","year":"1996"},{"key":"10.1006\/taap.2000.8924_RF20","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1046\/j.1471-4159.1995.64051909.x","article-title":"Anticholinesterases: Medical applications of neurochemical principles","volume":"64","author":"Millard","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1006\/taap.2000.8924_RF21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0300-483X(97)00157-1","article-title":"Rat brain acetylcholinesterase activity: Developmental profile and maturational sensitivity to carbamate and organophosphorus inhibitors","volume":"125","author":"Mortensen","year":"1998","journal-title":"Toxicology"},{"key":"10.1006\/taap.2000.8924_RF22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-9629(94)90307-7","article-title":"The determinants of contractility in the heart","volume":"109A","author":"Penefsky","year":"1994","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1006\/taap.2000.8924_RF23","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/0006-8993(86)90129-0","article-title":"Medullary pressor area: Site of action of intravenous physostigmine","volume":"382","author":"Punnen","year":"1986","journal-title":"Brain. Res."},{"key":"10.1006\/taap.2000.8924_RF24","first-page":"225","article-title":"Central respiratory effects versus neuromuscular actions of nerve agents","volume":"7","author":"Rickett","year":"1986","journal-title":"Neurotoxicology"},{"key":"10.1006\/taap.2000.8924_RF25","series-title":"Statistical Methods","first-page":"83","article-title":"The comparison of two samples","author":"Snedecor","year":"1989"},{"key":"10.1006\/taap.2000.8924_RF26","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0165-6147(97)89540-5","article-title":"The role of excitotoxicity in organophosphorous nerve agents central poisoning","volume":"18","author":"Solberg","year":"1997","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1006\/taap.2000.8924_RF27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/372231a0","article-title":"Signal transduction and regulation in smooth muscle","volume":"372","author":"Somlyo","year":"1994","journal-title":"Nature"},{"key":"10.1006\/taap.2000.8924_RF28","first-page":"309","article-title":"Effect of a cholinesterase inhibitor when injected into the medulla of the rabbit","volume":"162","author":"Stewart","year":"1968","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2000.8924_RF29","first-page":"465","article-title":"Pharmacology of reticulospinal vasomotor neurons in cardiovascular regulation","volume":"48","author":"Sun","year":"1996","journal-title":"Pharmacol. Rev."},{"key":"10.1006\/taap.2000.8924_RF30","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0272-0590(87)90091-1","article-title":"Contribution of monoaminergic nervous system in potentiation of 2-sec-butylphenyl N-methylcarbamate (BPMC) toxicity by malathion in male mice","volume":"8","author":"Takahashi","year":"1987","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1006\/taap.2000.8924_RF31","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0272-0590(91)90086-J","article-title":"Differences in the mode of lethality produced through intravenous and oral administration of organophosphorus insecticides in rats","volume":"16","author":"Takahashi","year":"1991","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1006\/taap.2000.8924_RF32","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0300-483X(94)90078-7","article-title":"Non-cholinergic lethality following intravenous injection of carbamate insecticide in rabbits","volume":"93","author":"Takahashi","year":"1994","journal-title":"Toxicology"},{"key":"10.1006\/taap.2000.8924_RF33","series-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","first-page":"177","article-title":"Agents acting at the neuromuscular junction and autonomic ganglia","author":"Taylor","year":"1996"},{"key":"10.1006\/taap.2000.8924_RF34","series-title":"The Pesticide Manual","author":"Tomlin","year":"1994"},{"key":"10.1006\/taap.2000.8924_RF35","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1139\/o81-101","article-title":"Activation and inactivation of acetylcholinesterase by metal ions","volume":"59","author":"Tomlinson","year":"1981","journal-title":"Can. J. Biochem."},{"key":"10.1006\/taap.2000.8924_RF36","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1006\/taap.1993.1199","article-title":"Correlation of the anticholinesterase activity of a series of organophosphates with their ability to compete with agonist binding to muscarinic receptors","volume":"122","author":"Ward","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.8924_RF37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3109\/01480548309017812","article-title":"Economical LD50 and slope determinations","volume":"6","author":"Weil","year":"1983","journal-title":"Drug Chem. Toxicol."},{"key":"10.1006\/taap.2000.8924_RF38","first-page":"457","article-title":"Cardiovascular control by cholinergic mechanisms in the rostral ventrolateral medulla","volume":"231","author":"Willette","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2000.8924_RF39","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/009841096161429","article-title":"Factors in standardizing automated cholinesterase assays","volume":"48","author":"Wilson","year":"1996","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1006\/taap.2000.8924_RF40","first-page":"32","article-title":"An alteration in sensitivity to cholinergic agents on guinea-pig ilea and atria after repeated administration of an organophosphate and an antagonism by a carbamate","volume":"241","author":"Yamada","year":"1979","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1006\/taap.2000.8924_RF41","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3109\/08037059709061934","article-title":"The cardiovascular response to medullary cholinergic and corticoid stimulation is calcium channel dependent in rats","volume":"6","author":"Zhu","year":"1997","journal-title":"Blood Pressure"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X00989245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X00989245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T12:17:45Z","timestamp":1576498665000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X00989245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,5]]}},"alternative-id":["S0041008X00989245"],"URL":"https:\/\/doi.org\/10.1006\/taap.2000.8924","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,5]]}}}