{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:55:21Z","timestamp":1791089721247,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2000,7]]},"DOI":"10.1006\/taap.2000.8952","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"92-100","source":"Crossref","is-referenced-by-count":53,"title":["Enhanced Hepatotoxicity and Toxic Outcome of Thioacetamide in Streptozotocin-Induced Diabetic Rats"],"prefix":"10.1006","volume":"166","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel D.","family":"Fontenot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhusudan G.","family":"Soni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Bucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harihara M.","family":"Mehendale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2000.8952_RF1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/jez.1402010111","article-title":"Liver regeneration in normal and alloxan-induced diabetic rats","volume":"201","author":"Barra","year":"1977","journal-title":"J. Exp. Zool."},{"key":"10.1006\/taap.2000.8952_RF2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1042\/bj0620315","article-title":"A study of the conditions and mechanisms of the diphenylamine reaction for positive colorimetric estimation of DNA","volume":"62","author":"Burton","year":"1956","journal-title":"Biochem. J."},{"key":"10.1006\/taap.2000.8952_RF3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/07435808609035434","article-title":"Paradoxical effects of glucose feeding on liver regeneration and survival after partial hepatectomy","volume":"12","author":"Caruana","year":"1986","journal-title":"Endocr. Res."},{"key":"10.1006\/taap.2000.8952_RF4","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1096\/fasebj.9.2.7781926","article-title":"Nutritional impact on the final outcome of liver injury inflicted by model hepatotoxins: Effect of glucose loading","volume":"9","author":"Chanda","year":"1995","journal-title":"FASEB J."},{"key":"10.1006\/taap.2000.8952_RF5","first-page":"1817","article-title":"A biochemical and autoradiography study of the in vivo utilization of tritiated thymidine in regenerating rat liver","volume":"25","author":"Chang","year":"1965","journal-title":"Cancer Res."},{"key":"10.1006\/taap.2000.8952_RF6","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0014-4827(56)90107-0","article-title":"Isolation of pure and unaltered liver nuclei morphology and biochemical composition","volume":"11","author":"Chauveau","year":"1956","journal-title":"Exp. Cell Res."},{"key":"10.1006\/taap.2000.8952_RF7","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1006\/bbrc.1994.2097","article-title":"Elevated glucose concentrations inhibit DNA synthesis and expression of c-myc in cultured hepatocytes","volume":"202","author":"Dajani","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.2000.8952_RF8","first-page":"443","article-title":"Influence of the conjoint administration of insulin and glucagon upon hepatic regeneration","volume":"163","author":"de Diego","year":"1986","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1006\/taap.2000.8952_RF9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0378-4274(83)90241-2","article-title":"Potentiation of thioacetamide-induced hepatotoxicity in alloxan- and streptozotocin-diabetic rats","volume":"17","author":"El-Hawari","year":"1983","journal-title":"Toxicol. Lett."},{"key":"10.1006\/taap.2000.8952_RF10","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0304-3835(91)90149-C","article-title":"An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues","volume":"54","author":"Greenwell","year":"1991","journal-title":"Cancer Lett."},{"key":"10.1006\/taap.2000.8952_RF11","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0168-8278(90)90141-D","article-title":"Failure of insulin and glucagon infusion to stimulate liver regeneration in fulminant hepatic failure","volume":"10","author":"Harrison","year":"1990","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2000.8952_RF12","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/ajcp\/112.3.351","article-title":"Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis","volume":"112","author":"Horn","year":"1999","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1006\/taap.2000.8952_RF13","first-page":"439","article-title":"Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system","volume":"200","author":"Hunter","year":"1977","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2000.8952_RF14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1365-2362.1986.tb01013.x","article-title":"Hepatic regeneration and metabolism after partial hepatectomy in diabetic rats: Effects of insulin therapy","volume":"16","author":"Johnston","year":"1986","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1006\/taap.2000.8952_RF15","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1289\/ehp.96104744","article-title":"Effect of colchicine antimitosis on thioacetamide hepatotoxicity","volume":"104","author":"Mangipudy","year":"1996","journal-title":"Environ. Health Perspect."},{"key":"10.1006\/taap.2000.8952_RF16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0006-2952(91)90249-5","article-title":"Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury. A two stage model of hepatotoxicity","volume":"42","author":"Mehendale","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2000.8952_RF17","first-page":"1067","article-title":"Effect of insulin on DNA synthesis and kinetic parameters of thymidine kinase during liver regeneration","volume":"40","author":"Mola","year":"1996","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1006\/taap.2000.8952_RF18","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0039-6060(97)90283-X","article-title":"Progressive necrosis after hepatectomy and the pathophysiology of liver failure after massive resection","volume":"121","author":"Panis","year":"1997","journal-title":"Surgery"},{"key":"10.1006\/taap.2000.8952_RF19","first-page":"386","article-title":"Thioacetamide-induced hepatic necrosis. II. Pharmacokinetics of thioacetamide and thioacetamide-S-oxide in the rat","volume":"208","author":"Porter","year":"1979","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2000.8952_RF20","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1006\/taap.1998.8365","article-title":"Diet restriction enhances compensatory liver tissue repair and survival following administration of lethal dose of thioacetamide","volume":"150","author":"Ramaiah","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.8952_RF21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1080\/109158199225215","article-title":"High glucose concentration alters cell proliferation dynamics in human hepatoma cell","volume":"18","author":"Rao","year":"1999","journal-title":"Int. J. Toxicol."},{"key":"10.1006\/taap.2000.8952_RF22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0076-6879(91)06102-9","article-title":"Induction of diabetes and evaluation of diabetic state on P450 expression","volume":"206","author":"Schenkman","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1006\/taap.2000.8952_RF23","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/hep.510290241","article-title":"Repeat exposure to incremental doses of acetaminophen provides protection against acetaminophen-induced lethality in mice: An explanation for high acetaminophen dosage in humans without hepatic injury","volume":"29","author":"Shayiq","year":"1999","journal-title":"Hepatology"},{"key":"10.1006\/taap.2000.8952_RF24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0168-8278(05)80068-6","article-title":"Adenosine triphosphate protection of chlordecone-amplified CCl4 hepatotoxicity and lethality","volume":"20","author":"Soni","year":"1994","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2000.8952_RF25","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/rtph.1998.1280","article-title":"Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology","volume":"29","author":"Soni","year":"1999","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1006\/taap.2000.8952_RF26","first-page":"843","article-title":"Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration","volume":"141","author":"Starzl","year":"1975","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1006\/taap.2000.8952_RF27","first-page":"549","article-title":"The effect of diabetes mellitus on portal blood hepatotrophic factors in dogs","volume":"140","author":"Starzl","year":"1975","journal-title":"Surg. Gynecol. Obstet."},{"key":"10.1006\/taap.2000.8952_RF28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/bies.950190410","article-title":"Insulin second messengers","volume":"19","author":"Stralfors","year":"1997","journal-title":"Bioessays"},{"key":"10.1006\/taap.2000.8952_RF29","article-title":"Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1","volume":"294","author":"Wang","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2000.8952_RF30","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/00000658-197701000-00006","article-title":"Insulin requirements for hepatic regeneration following hepatectomy","volume":"185","author":"Yamada","year":"1977","journal-title":"Ann. Surg."},{"key":"10.1006\/taap.2000.8952_RF31","first-page":"1408","article-title":"Hepatic proliferative response to insulin in severe alloxan diabetes","volume":"26","author":"Younger","year":"1966","journal-title":"Cancer Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X0098952X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X0098952X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T19:34:50Z","timestamp":1576524890000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X0098952X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,7]]}},"alternative-id":["S0041008X0098952X"],"URL":"https:\/\/doi.org\/10.1006\/taap.2000.8952","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2000,7]]}}}