{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T19:11:57Z","timestamp":1776280317846,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,4,1]],"date-time":"2001-04-01T00:00:00Z","timestamp":986083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2001,4]]},"DOI":"10.1006\/taap.2000.9110","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:01:25Z","timestamp":1032372085000},"page":"83-92","source":"Crossref","is-referenced-by-count":32,"title":["Repeated Inhalation Exposure to Octamethylcyclotetrasiloxane Produces Hepatomegaly, Transient Hepatic Hyperplasia, and Sustained Hypertrophy in Female Fischer 344 Rats in a Manner Similar to Phenobarbital"],"prefix":"10.1006","volume":"172","author":[{"suffix":"Jr.","given":"James M.","family":"McKim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary B.","family":"Kolesar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul A.","family":"Jean","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"Meeker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul C.","family":"Wilga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Schoonhoven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Swenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay I.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert H.","family":"Gallavan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Meeks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2000.9110_RF1","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1006\/taap.1996.0325","article-title":"Effects of doxylamine succinate on thyroid hormone balance and enzyme induction in mice","volume":"141","author":"Bookstaff","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF2","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/j.1460-2075.1985.tb03679.x","article-title":"Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis dependent on DNA synthesis","volume":"4","author":"Bravo","year":"1987","journal-title":"EMBO J."},{"key":"10.1006\/taap.2000.9110_RF3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/0147-6513(78)90014-3","article-title":"Is phenobarbital carcinogenic? A follow-up of 8078 epileptics","volume":"1","author":"Clemmesen","year":"1978","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1006\/taap.2000.9110_RF4","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0092-8674(95)90228-7","article-title":"Alterations in DNA methylation may play a variety of roles in carcinogenesis","volume":"83","author":"Counts","year":"1995","journal-title":"Cell"},{"key":"10.1006\/taap.2000.9110_RF5","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/carcin\/17.6.1251","article-title":"Cell proliferation and global methylation status changes in mouse liver after phenobarbital and\/or choline-devoid, methionine-deficient diet administration","volume":"17","author":"Counts","year":"1996","journal-title":"Carcinogenesis"},{"key":"10.1006\/taap.2000.9110_RF6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/0041-008X(91)90050-O","article-title":"Relationship of hepatocarcinogenicity and hepatocellular proliferation induced by mutagenic noncarcinogens vs carcinogens. II. 1- vs 2-Nitropropane","volume":"110","author":"Cunningham","year":"1991","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF7","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/carcin\/11.12.2245","article-title":"Measurement of chemically induced cell proliferation in rodent liver and kidney: A comparison of 5-bromo-2\u2032-deoxyuridine and [3H]thymidine administered by injection or osmotic pump","volume":"11","author":"Eldridge","year":"1990","journal-title":"Carcinogenesis"},{"key":"10.1006\/taap.2000.9110_RF8","first-page":"1","article-title":"Assessing proliferation and apoptosis in liver tumor development","volume":"15","author":"Goldsworthy","year":"1995","journal-title":"Chem. Ind. Inst. Toxicol. (CIIT)"},{"key":"10.1006\/taap.2000.9110_RF9","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1006\/faat.1996.0016","article-title":"Biochemical effects of the mouse hepatocarcinogen oxazepam: Similarities to phenobarbital","volume":"29","author":"Griffin","year":"1996","journal-title":"Fundam. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF10","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1093\/carcin\/15.9.1917","article-title":"Modulation of phenobarbitone-induced loss of gap junctional intercellular communication in hepatocyte couplets","volume":"15","author":"Guppy","year":"1994","journal-title":"Carcinogenesis"},{"key":"10.1006\/taap.2000.9110_RF11","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/taap.1999.8752","article-title":"Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy","volume":"160","author":"Hood","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/toxsci\/50.1.45","article-title":"Effects of phenobarbital, pregnenolone-16\u03b1-carbonitrile, and propylthiouracil on thyroid follicular cell proliferation","volume":"50","author":"Hood","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2000.9110_RF13","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1177\/019262339802600210","article-title":"Effect of phenobarbital on hepatic gap junctional intercellular communication in rats","volume":"26","author":"Ito","year":"1998","journal-title":"Toxicol. Pathol."},{"key":"10.1006\/taap.2000.9110_RF14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/BF01974069","article-title":"Assessment of the influence of subacute phenobarbitone administration on multi-tissue cell proliferation in the rat using bromodeoxyuridine immunocytochemistry","volume":"67","author":"Jones","year":"1993","journal-title":"Arch. Toxicol."},{"key":"10.1006\/taap.2000.9110_RF15","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/0006-2952(92)90614-O","article-title":"A pleiotropic response to phenobarbital-type enzyme inducers in the F344\/NCr rat: Effects of chemicals of varied structure","volume":"43","author":"Lubet","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1177\/019262338901700206","article-title":"The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: Implications for thyroid gland neoplasia","volume":"17","author":"McClain","year":"1989","journal-title":"Toxicol. Pathol."},{"key":"10.1006\/taap.2000.9110_RF17","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/0041-008X(89)90004-5","article-title":"The effect of phenobarbital on the metabolism and excretion of thyroxine in rats","volume":"99","author":"McClain","year":"1989","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/toxsci\/41.1.29","article-title":"Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: A 28 day inhalation study","volume":"41","author":"McKim","year":"1998","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2000.9110_RF19","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1080\/15298668091425743","article-title":"Improved methodology for generating controlled test atmospheres","volume":"41","author":"Miller","year":"1980","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"10.1006\/taap.2000.9110_RF20","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/jnci\/81.10.803","article-title":"Cancer among epileptic patients exposed to anticonvulsant drugs","volume":"81","author":"Olsen","year":"1989","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1006\/taap.2000.9110_RF21","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/bjc.1990.424","article-title":"Cancer in children of epileptic mothers and the possible relation to maternal anticonvulsant therapy","volume":"62","author":"Olsen","year":"1990","journal-title":"Br. J. Cancer"},{"key":"10.1006\/taap.2000.9110_RF22","first-page":"449","article-title":"Phenobarbital, drug metabolism, and human cancer","volume":"2","author":"Olsen","year":"1993","journal-title":"Cancer Epidemiol."},{"key":"10.1006\/taap.2000.9110_RF23","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/0006-2952(92)90176-J","article-title":"Evaluation of loratadine as an inducer of liver microsomal cytochrome P450 in rats and mice","volume":"43","author":"Parkinson","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2000.9110_RF24","first-page":"1506","article-title":"Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene","volume":"31","author":"Peraino","year":"1971","journal-title":"Cancer Res."},{"key":"10.1006\/taap.2000.9110_RF25","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3109\/10408447409079856","article-title":"Induction of liver growth by xenobiotic compounds and other stimuli","volume":"3","author":"Schulte-Hermann","year":"1974","journal-title":"CRC Crit. Rev. Toxicol."},{"key":"10.1006\/taap.2000.9110_RF26","series-title":"Toxic Injury of the Liver, Part A","first-page":"385","article-title":"Reactions of the liver to injury: Adaptation","author":"Schulte-Hermann","year":"1979"},{"key":"10.1006\/taap.2000.9110_RF27","first-page":"83","article-title":"Cancer incidence in a cohort of patients with seizure disorders","volume":"77","author":"Shirts","year":"1986","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1006\/taap.2000.9110_RF28","first-page":"1153","article-title":"Constant gassing chambers: Principles influencing design and operation","volume":"31","author":"Silver","year":"1946","journal-title":"J. Lab. Clin. Med."},{"key":"10.1006\/taap.2000.9110_RF29","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1080\/0002889708506254","article-title":"The use of plastic bags for industrial air sampling","volume":"31","author":"Smith","year":"1970","journal-title":"Am. Ind. Hyg. Assoc. J."},{"key":"10.1006\/taap.2000.9110_RF30","unstructured":"Swenberg, J. A., Dietrich, D. R., McClain, R. M., and Cohen, S. M.1992. Species-specific mechanisms of carcinogenesis. In Mechanisms of Carcinogenesis in Risk Identification (H. Varnio, P. N. Magee, D. B. McGregor, and A. J. McMichael, Eds.), pp. 477\u2013500. IARC, Lyon."},{"key":"10.1006\/taap.2000.9110_RF31","doi-asserted-by":"crossref","first-page":"132S","DOI":"10.1042\/bst022132s","article-title":"Origins of hepatomegaly produced by dexamethasone (DEX), pregnenolone 16 alpha-carbonitrile (PCN) and phenobarbitone (PB) in female Sprague Dawley rats","volume":"22","author":"Thatcher","year":"1994","journal-title":"Biochem. Soc. Trans."},{"key":"10.1006\/taap.2000.9110_RF32","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1002\/1097-0142(19800615)45:12<2975::AID-CNCR2820451215>3.0.CO;2-F","article-title":"New dimensions in the biology of cancer","volume":"45","author":"Weinhouse","year":"1980","journal-title":"Cancer"},{"key":"10.1006\/taap.2000.9110_RF33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0163-7258(96)00067-8","article-title":"Phenobarbital mechanistic data and risk assessment: Enzyme induction, enhanced cell proliferation, and tumor promotion","volume":"71","author":"Whysner","year":"1996","journal-title":"Pharmacol. Ther."},{"key":"10.1006\/taap.2000.9110_RF34","first-page":"465","article-title":"Mirex-induced adaptive liver growth: A corticosterone-mediated response","volume":"17","author":"Yarbrough","year":"1984","journal-title":"Cell Tissue Kinet."},{"key":"10.1006\/taap.2000.9110_RF35","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/hep.1840150528","article-title":"Mirex-induced adaptive liver growth in rats subjected to thyroidectomy","volume":"15","author":"Yarbrough","year":"1992","journal-title":"Hepatology"},{"key":"10.1006\/taap.2000.9110_RF36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0009-2797(99)00153-2","article-title":"Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes","volume":"124","author":"Zhang","year":"2000","journal-title":"Chem.\u2013Biol. Interact."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X00991105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X00991105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T18:16:34Z","timestamp":1576520194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X00991105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,4]]}},"alternative-id":["S0041008X00991105"],"URL":"https:\/\/doi.org\/10.1006\/taap.2000.9110","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}