{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:13:19Z","timestamp":1772896399542,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1006\/taap.2001.9205","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"199-206","source":"Crossref","is-referenced-by-count":15,"title":["Hard Metal-Induced Disease: Effects of Metal Cations in Vitro on Guinea Pig Isolated Airways"],"prefix":"10.1006","volume":"174","author":[{"given":"Jeffrey S.","family":"Fedan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Cutler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2001.9205_RF1","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/annhyg\/41.5.515","article-title":"A study on lung toxicity of respirable hard metal dusts in rats","volume":"41","author":"Adamis","year":"1997","journal-title":"Ann. Occup. Hyg."},{"key":"10.1006\/taap.2001.9205_RF2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/BF00169372","article-title":"Biphasic increase in cytosolic free calcium induced by bradykinin and histamine in cultured tracheal smooth muscle cells: Is the sustained phase artifactual?","volume":"350","author":"Amrani","year":"1994","journal-title":"Naunyn-Schmiedeberg's Arch. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF3","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/S0006-3495(96)79377-3","article-title":"Similarity in calcium channel activity of annexin V and matrix vesicles in planar lipid bilayers","volume":"71","author":"Arispe","year":"1996","journal-title":"Biophys. J."},{"key":"10.1006\/taap.2001.9205_RF4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1081\/CLT-100102418","article-title":"Chromium","volume":"37","author":"Barceloux","year":"1999","journal-title":"Clin. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1081\/CLT-100102420","article-title":"Cobalt","volume":"37","author":"Barceloux","year":"1999","journal-title":"Clin. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1081\/CLT-100102423","article-title":"Nickel","volume":"37","author":"Barceloux","year":"1999","journal-title":"Clin. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1081\/CLT-100102426","article-title":"Zinc","volume":"37","author":"Barceloux","year":"1999","journal-title":"Clin. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF8","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0378-4274(99)00286-6","article-title":"Intratracheal exposure of the guinea pig lung to cadmium and\/or selenium: A histological evaluation","volume":"114","author":"Bell","year":"2000","journal-title":"Toxicol. Lett."},{"key":"10.1006\/taap.2001.9205_RF9","series-title":"Asthma in the Workplace","author":"Bernstein","year":"1999"},{"key":"10.1006\/taap.2001.9205_RF10","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1016\/0306-3623(94)90379-4","article-title":"The pharmacological effects of cadmium on skeletal neuromuscular transmission","volume":"25","author":"Braga","year":"1994","journal-title":"Gen. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF11","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/0378-4274(95)03559-1","article-title":"Calcium channels as target sites of heavy metals","volume":"82\u201383","author":"Busselberg","year":"1995","journal-title":"Toxicol. Lett."},{"key":"10.1006\/taap.2001.9205_RF12","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1469-7793.1997.165bc.x","article-title":"The removal of acetylcholine by diffusion at nicotinic synapses in the rat otic ganglion","volume":"505","author":"Callister","year":"1997","journal-title":"J. Physiol."},{"key":"10.1006\/taap.2001.9205_RF13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0272-5231(21)00856-X","article-title":"The hard metal diseases","volume":"13","author":"Cugell","year":"1992","journal-title":"Clin. Chest Med."},{"key":"10.1006\/taap.2001.9205_RF14","first-page":"L620","article-title":"Roles of Ca2+ influx and intracellular Ca2+ release in agonist-induced contractions in guinea-pig trachea","volume":"266","author":"Cuthbert","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9205_RF15","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1093\/toxsci\/52.2.278","article-title":"Thirteen-week subchronic rat inhalation toxicity study with a recovery phase of trivalent chromium compounds, chromic oxide, and basic chromium sulfate","volume":"52","author":"Derelanko","year":"1999","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2001.9205_RF16","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0300-483X(96)03404-X","article-title":"Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures","volume":"112","author":"Hassoun","year":"1996","journal-title":"Toxicology"},{"key":"10.1006\/taap.2001.9205_RF17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-2999(86)90330-4","article-title":"Airway epithelium modulates smooth muscle reactivity","volume":"129","author":"Hay","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF18","doi-asserted-by":"crossref","first-page":"C1757","DOI":"10.1152\/ajpcell.1997.272.6.C1757","article-title":"T-type and L-type Ca2+ currents in canine bronchial smooth muscle: Characterization and physiological roles","volume":"272","author":"Janssen","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9205_RF19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/0002889758507202","article-title":"Cobalt metal inhalation studies on miniature swine","volume":"36","author":"Kerfoot","year":"1975","journal-title":"Am. Ind. Hyg. J."},{"key":"10.1006\/taap.2001.9205_RF20","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/j.1469-7793.1999.0843p.x","article-title":"Regulation of baseline cholinergic tone in guinea-pig airway smooth muscle","volume":"518","author":"Kesler","year":"1999","journal-title":"J. Physiol.."},{"key":"10.1006\/taap.2001.9205_RF21","doi-asserted-by":"crossref","first-page":"C793","DOI":"10.1152\/ajpcell.1988.254.6.C793","article-title":"Calcium currents in isolated canine airway smooth muscle cells","volume":"254","author":"Kotlikoff","year":"1988","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9205_RF22","first-page":"486","article-title":"Effect of hard metal dust on ventilatory function","volume":"43","author":"Kusaka","year":"1986","journal-title":"Br. J. Ind. Med."},{"key":"10.1006\/taap.2001.9205_RF23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/enrs.1995.1032","article-title":"The delayed lung responses to single and repeated intratracheal administration of pure cobalt and hard metal powder in the rat","volume":"69","author":"Lasfargues","year":"1995","journal-title":"Environ. Res."},{"key":"10.1006\/taap.2001.9205_RF24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0041-008X(92)90277-Y","article-title":"Comparative study of the acute lung toxicity of pure cobalt and cobalt-tungsten carbide mixture in the rat","volume":"112","author":"Lasfargues","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF25","doi-asserted-by":"crossref","first-page":"585","DOI":"10.3109\/10408449609037478","article-title":"Human toxicity of cobalt-containing dust and experimental studies on the mechanism of interstitial lung disease (hard metal disease)","volume":"26","author":"Lison","year":"1996","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF26","first-page":"585","article-title":"Physicochemical mechanism of the interaction between cobalt metal and carbide particles to generate toxic activated oxygen species","volume":"26","author":"Lison","year":"1995","journal-title":"Chem. Res. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF27","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s002040050108","article-title":"Cobalt bioavailability from hard metal particles. Further evidence that cobalt alone is not responsible for the toxicity of hard metal particles","volume":"68","author":"Lison","year":"1994","journal-title":"Arch. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF28","first-page":"L852","article-title":"Refilling of caffeine-sensitive intracellular calcium stores in bovine airway smooth muscle cells","volume":"275","author":"Madison","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9205_RF29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1164\/ajrccm\/145.1.70","article-title":"Dysfunction of nonadrenergic noncholinergic inhibitory system after antigen inhalation in actively sensitized cat airways","volume":"145","author":"Miura","year":"1992","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1006\/taap.2001.9205_RF30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/sj.bjp.0702786","article-title":"Characterization of non-adrenergic, non-cholinergic inhibitory responses of the isolated guinea-pig trachea: Differences between pre- and post-ganglionic nerve stimulation","volume":"128","author":"Moffat","year":"1999","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF31","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1006\/taap.1999.8668","article-title":"Effects of hard metal on nitric oxide pathways and airway reactivity to methacholine in rat lungs","volume":"157","author":"Rengasamy","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF32","first-page":"957","article-title":"Nonadrenergic, noncholinergic contractile responses of the guinea pig hilar bronchus involve the preferential activation of tachykinin neurokinin2 receptors","volume":"262","author":"Renzetti","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2001.9205_RF33","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5271\/sjweh.111","article-title":"A fatal case of hard-metal disease","volume":"22","author":"Ruokonen","year":"1996","journal-title":"Scand. J. Work Environ. Health"},{"key":"10.1006\/taap.2001.9205_RF34","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1476-5381.1989.tb11919.x","article-title":"Antagonism of calcium by zinc in guinea-pig isolated taenia caeci and trachealis muscle","volume":"97","author":"Sarria","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF35","first-page":"127","article-title":"The biological action of particulate cobalt metal","volume":"12","author":"Schepers","year":"1955","journal-title":"Arch. Ind. Health"},{"key":"10.1006\/taap.2001.9205_RF36","first-page":"137","article-title":"The biological action of tungsten carbide and carbon","volume":"12","author":"Schepers","year":"1955","journal-title":"Arch. Ind. Health"},{"key":"10.1006\/taap.2001.9205_RF37","first-page":"140","article-title":"The biological action of tungsten carbide and cobalt","volume":"12","author":"Schepers","year":"1955","journal-title":"Arch. Ind. Health"},{"key":"10.1006\/taap.2001.9205_RF38","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1164\/ajrccm\/138.5.1220","article-title":"Cobalt exposure and lung disease in tungsten carbide production. A cross-sectional study of current workers","volume":"138","author":"Sprince","year":"1988","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1006\/taap.2001.9205_RF39","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/S0006-8993(97)01342-5","article-title":"Calcium spikes and calcium currents in neurons from the medial preoptic nucleus of rat","volume":"783","author":"Sundgren-Andersson","year":"1998","journal-title":"Brain Res."},{"key":"10.1006\/taap.2001.9205_RF40","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/sj.bjp.0701993","article-title":"Comparison of contractions produced by carbachol, thapsigargin and cyclopiazonic acid in the guinea-pig tracheal muscle","volume":"124","author":"Takemoto","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1006\/taap.1996.0320","article-title":"Metal-induced modulation of nitric oxide production in vitro by murine macrophages: Lead, nickel and cobalt utilize different mechanisms","volume":"141","author":"Tian","year":"1996","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9205_RF42","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/BF01973704","article-title":"Changes in the contractile responses to carbachol and in the inhibitory effects of verapamil and nitrendipine on isolated smooth muscle preparations from rats subchronically exposed to Co2+ and Ni2+","volume":"67","author":"Vassilev","year":"1993","journal-title":"Arch. Toxicol."},{"key":"10.1006\/taap.2001.9205_RF43","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0028-3908(92)90181-N","article-title":"Pharmacological heterogeneity among calcium channels that subserve acetylcholine release in vertebrate forebrain","volume":"31","author":"Vickroy","year":"1992","journal-title":"Neuropharmacology"},{"key":"10.1006\/taap.2001.9205_RF44","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3109\/10799899409101513","article-title":"Sarafotoxin-induced calcium mobilization in cultured dog tracheal smooth muscle cells","volume":"14","author":"Yang","year":"1994","journal-title":"J. Recept. Res."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01992051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01992051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T22:15:25Z","timestamp":1680560125000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X01992051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0041008X01992051"],"URL":"https:\/\/doi.org\/10.1006\/taap.2001.9205","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}