{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:01:02Z","timestamp":1787166062127,"version":"build-2736575974"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,8,1]],"date-time":"2001-08-01T00:00:00Z","timestamp":996624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2001,8]]},"DOI":"10.1006\/taap.2001.9216","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T18:01:25Z","timestamp":1032372085000},"page":"216-224","source":"Crossref","is-referenced-by-count":50,"title":["In Utero\/Lactational 2,3,7,8-Tetrachlorodibenzo-p-dioxin Exposure Impairs Molar Tooth Development in Rats"],"prefix":"10.1006","volume":"174","author":[{"given":"Hanna","family":"Kattainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Tuukkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Simanainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouni T.","family":"Tuomisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Outi","family":"Kovero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pirjo-Liisa","family":"Lukinmaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"Alaluusua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouko","family":"Tuomisto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Viluksela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2001.9216_RF1","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/taap.1994.1085","article-title":"Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression","volume":"126","author":"Abbott","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/tera.1420410108","article-title":"Effects of TCDD on embryonic ureteric epithelial EGFR receptor expression and cell proliferation","volume":"41","author":"Abbott","year":"1990","journal-title":"Teratology"},{"key":"10.1006\/taap.2001.9216_RF3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0300-483X(93)90152-I","article-title":"Exposure to 2,3,7,8-tetrachlorodibenzo-para-dioxin leads to defective dentin formation and pulpal perforation in rat incisor tooth","volume":"81","author":"Alaluusua","year":"1993","journal-title":"Toxicology"},{"key":"10.1006\/taap.2001.9216_RF4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S0140-6736(05)77214-7","article-title":"Developing teeth as biomarker of dioxin exposure","volume":"353","author":"Alaluusua","year":"1999","journal-title":"Lancet"},{"key":"10.1006\/taap.2001.9216_RF5","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/1382-6689(96)00007-5","article-title":"Polychlorinated dibenzo-p-dioxins and dibenzofurans via mother's milk may cause developmental defects in child's teeth","volume":"1","author":"Alaluusua","year":"1996","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF6","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/(SICI)1096-9926(199705)55:5<326::AID-TERA5>3.0.CO;2-X","article-title":"Effects of TCDD on Ah receptor, ARNT, EGF, and TGF-alpha expression in embryonic mouse urinary tract","volume":"55","author":"Bryant","year":"1997","journal-title":"Teratology"},{"key":"10.1006\/taap.2001.9216_RF7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/0041-008X(71)90282-1","article-title":"Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-p-dioxin","volume":"20","author":"Courtney","year":"1971","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/taap.1997.8222","article-title":"In utero exposure to low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) alters reproductive development of female Long Evans Hooded rat offspring","volume":"146","author":"Gray","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF9","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1006\/taap.1995.1052","article-title":"Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: Reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status","volume":"131","author":"Gray","year":"1995","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2307\/3429879","article-title":"Health status and PCBs in blood of workers exposed to PCBs and of their children","volume":"59","author":"Hara","year":"1985","journal-title":"Environ. Health Perspect."},{"key":"10.1006\/taap.2001.9216_RF11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/toxsci\/53.2.411","article-title":"Acute administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in pregnant Long Evans rats: Association of measured tissue concentrations with developmental effects","volume":"53","author":"Hurst","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2001.9216_RF12","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1006\/taap.1994.1021","article-title":"Developmental toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the most TCDD-resistant and -susceptible rat strains","volume":"124","author":"Huuskonen","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF13","first-page":"402","article-title":"A critical reassessment of current human dietary exposure to PCDDs and PCDFs in the UK","volume":"33","author":"Jacobs","year":"1997","journal-title":"Organohalogen Compounds"},{"key":"10.1006\/taap.2001.9216_RF14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/faat.1995.1109","article-title":"Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in female Sprague\u2013Dawley rats including placental and lactational transfer to fetuses and neonates","volume":"27","author":"Li","year":"1995","journal-title":"Fundam. Appl. Toxicol."},{"key":"10.1006\/taap.2001.9216_RF15","first-page":"13","article-title":"Dietary intake of dioxin and dioxin-like PCBs by the general population of ten European countries. Results of EU-SCOOP Task 3.2.5. (Dioxins)","volume":"48","author":"Liem","year":"2000","journal-title":"Organohalogen Compnd."},{"key":"10.1006\/taap.2001.9216_RF16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1006\/taap.2001.9155","article-title":"Arrest of rat molar tooth development by lactational exposure to 2, 3, 7, 8-tetrachroladibenzo-p-dio","volume":"173","author":"Lukinmaa","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0041-008X(92)90101-W","article-title":"In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Effects on androgenic status","volume":"114","author":"Mably","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF18","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0041-008X(92)90102-X","article-title":"In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 2. Effects on sexual behavior and the regulation of luteinizing hormone secretion in adulthood","volume":"114","author":"Mably","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/0041-008X(92)90103-Y","article-title":"In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin. 3. Effects on spermatogenesis and reproductive capability","volume":"114","author":"Mably","year":"1992","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF20","doi-asserted-by":"crossref","first-page":"7407","DOI":"10.1073\/pnas.81.23.7407","article-title":"Effects of in vivo-administered 2,3,7,8-tetrachlorodibenzo-p-dioxin on receptor binding of epidermal growth factor in the hepatic plasma membrane of rat, guinea pig, mouse, and hamster","volume":"81","author":"Madhukar","year":"1984","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/taap.2001.9216_RF21","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1046\/j.1365-2443.1997.1490345.x","article-title":"Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor","volume":"2","author":"Mimura","year":"1997","journal-title":"Genes Cells"},{"key":"10.1006\/taap.2001.9216_RF22","first-page":"1473","article-title":"Epidermal growth factor receptor as a mediator of developmental toxicity of dioxin in mouse embryonic teeth","volume":"78","author":"Partanen","year":"1998","journal-title":"Lab. Invest."},{"key":"10.1006\/taap.2001.9216_RF23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3109\/10408449309105013","article-title":"Developmental and reproductive toxicity of dioxins and related compounds: Cross-species comparisons","volume":"23","author":"Peterson","year":"1993","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1006\/taap.2001.9216_RF24","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1600-0773.1987.tb01514.x","article-title":"Han\/Wistar rats are exceptionally resistant to TCDD","volume":"60","author":"Pohjanvirta","year":"1987","journal-title":"Pharmacol. Toxicol."},{"key":"10.1006\/taap.2001.9216_RF25","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1124\/mol.54.1.86","article-title":"Point mutation in intron sequence causes altered carboxyl-terminal structure in the aryl hydrocarbon receptor of the most 2,3,7,8-tetrachlorodibenzo-p-dioxin-resistant rat strain","volume":"54","author":"Pohjanvirta","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF26","first-page":"85","article-title":"Proliferation of periodontal squamous epithelium in mink fed with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)","volume":"42","author":"Render","year":"2000","journal-title":"Vet. Hum. Toxicol."},{"key":"10.1006\/taap.2001.9216_RF27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/104063870001200518","article-title":"Proliferation of maxillary and mandibular periodontal squamous cells in mink fed 3,3\u2032,4,4\u2032,5-pentachlorobiphenyl (PCB 126)","volume":"12","author":"Render","year":"2000","journal-title":"J. Vet. Diagn. Invest."},{"key":"10.1006\/taap.2001.9216_RF28","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1126\/science.3133768","article-title":"Congenital poisoning by polychlorinated biphenyls and their contaminants in Taiwan","volume":"241","author":"Rogan","year":"1988","journal-title":"Science"},{"key":"10.1006\/taap.2001.9216_RF29","series-title":"Dental Anatomy and Embryology","first-page":"432","article-title":"The dentition of laboratory rodents and lagomorphs","author":"Shellis","year":"1981"},{"key":"10.1006\/taap.2001.9216_RF30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1006\/taap.1997.8173","article-title":"In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin: Effects on developmental of the male and female reproductive system of the mouse","volume":"145","author":"Theobald","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF31","series-title":"Embryos, Genes and Birth Defects","first-page":"329","article-title":"The teeth","author":"Thesleff","year":"1997"},{"key":"10.1006\/taap.2001.9216_RF32","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/taap.1998.8564","article-title":"The AH receptor and a novel gene determine acute toxic responses to TCDD: Segregation of the resistant alleles to different rat lines","volume":"153","author":"Tuomisto","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9216_RF33","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/toxsci\/51.2.259","article-title":"Gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) severely alters reproductive function of female hamster offspring","volume":"51","author":"Wolf","year":"1999","journal-title":"Toxicol. Sci."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01992166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01992166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T11:32:07Z","timestamp":1576495927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X01992166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["S0041008X01992166"],"URL":"https:\/\/doi.org\/10.1006\/taap.2001.9216","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}