{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:15:45Z","timestamp":1777482945927,"version":"3.51.4"},"reference-count":60,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2001,9,1]],"date-time":"2001-09-01T00:00:00Z","timestamp":999302400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2001,9]]},"DOI":"10.1006\/taap.2001.9234","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"130-139","source":"Crossref","is-referenced-by-count":87,"title":["Increased Oxidative Stress in Dimethylnitrosamine-Induced Liver Fibrosis in the Rat: Effect of N-Acetylcysteine and Interferon-\u03b1"],"prefix":"10.1006","volume":"175","author":[{"given":"Gianluigi","family":"Vendemiale","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignazio","family":"Grattagliano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Lucia","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Serviddio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Valentini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Pirrelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Altomare","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2001.9234_RF1","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0006-291X(87)90753-4","article-title":"Rapid oxidative stress induced by N-nitrosamines","volume":"146","author":"Ahotupa","year":"1987","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.2001.9234_RF2","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/bj2440075","article-title":"Gene expression of type I, III and IV collagens in hepatic fibrosis induced by dimethylnitrosamine in the rat","volume":"244","author":"Ala-Kokko","year":"1987","journal-title":"Biochem. J."},{"key":"10.1006\/taap.2001.9234_RF3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ajcp\/82.2.191","article-title":"Immunocytochemical enhancement of basement membrane antigens by pepsin: Applications in diagnostic pathology","volume":"82","author":"Barsky","year":"1984","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1006\/taap.2001.9234_RF4","first-page":"758","article-title":"Acetaldehyde increases procollagen type I and fibronectin gene transcription in cultured rat fat-storing cells through a protein synthesis-dependent mechanism","volume":"13","author":"Casini","year":"1991","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1089\/jir.1983.3.387","article-title":"Human interferon and cell growth inhibition. VII. Reversibility of interferon activities","volume":"3","author":"Dahl","year":"1983","journal-title":"J. Interferon Res."},{"key":"10.1006\/taap.2001.9234_RF6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/1097-0142(19890115)63:2<272::AID-CNCR2820630212>3.0.CO;2-L","article-title":"Distribution of basement membrane components in human hepatocellular carcinoma","volume":"63","author":"Donato","year":"1989","journal-title":"Cancer"},{"key":"10.1006\/taap.2001.9234_RF7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Elmann","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1006\/taap.2001.9234_RF8","series-title":"Drug-Induced Hepatotoxicity","first-page":"1","article-title":"Orientations in liver toxicity by drugs","author":"Farber","year":"1996"},{"key":"10.1006\/taap.2001.9234_RF9","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1002\/hep.510230625","article-title":"Hepatocyte proliferative activity in chronic liver damage as assessed by monoclonal antibody MIBI Ki67 in archival material: The role of etiology, disease activity, iron and lipid peroxidation","volume":"23","author":"Farinati","year":"1996","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0168-8278(98)80012-3","article-title":"Effects of long-term administration of interferon-\u03b1 in two models of liver fibrosis in rats","volume":"29","author":"Fort","year":"1998","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-2008-1040454","article-title":"Cellular sources of collagen and regulation of collagen production in liver","volume":"10","author":"Friedman","year":"1990","journal-title":"Semin. Liver Dis."},{"key":"10.1006\/taap.2001.9234_RF12","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"The cellular basis of hepatic fibrosis: Mechanism and treatment strategies","volume":"328","author":"Friedman","year":"1993","journal-title":"N. Engl. J. Med."},{"key":"10.1006\/taap.2001.9234_RF13","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: The principal collagen producin cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/taap.2001.9234_RF14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0168-8278(96)80074-2","article-title":"Effects of S-adenosylmethionine on lipid peroxidation and liver fibrogenesis in carbon tetrachloride-induced cirrhosis","volume":"25","author":"Gass\u00f2","year":"1996","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1089\/jir.1993.13.227","article-title":"Analysis of interferon-alpha 2 sequences in human genomic DNA","volume":"13","author":"Gewert","year":"1993","journal-title":"J. Interferon Res."},{"key":"10.1006\/taap.2001.9234_RF16","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0042-6822(83)90082-X","article-title":"High and low potency interferon-alpha subtypes induce (2\u2032-5\u2032) oligoadenylate synthetase with similar efficiency","volume":"130","author":"Goren","year":"1983","journal-title":"Virology"},{"key":"10.1006\/taap.2001.9234_RF17","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1055\/s-2008-1040455","article-title":"Cellular sources of noncollagenous matrix proteins: Role of fat-storing cells in fibrogenesis","volume":"10","author":"Gressner","year":"1990","journal-title":"Semin. Liver Dis."},{"key":"10.1006\/taap.2001.9234_RF18","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/0016-5085(94)90237-2","article-title":"Excess iron into hepatocytes is required for activation of collagen type I gene during experimental siderosis","volume":"107","author":"Gualdi","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1006\/taap.2001.9234_RF19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/0168-8278(95)80255-X","article-title":"Serum hyaluronan as a marker of liver fibrosis in chronic viral hepatitis C: Effect of \u03b1-interferon therapy","volume":"22","author":"Guechot","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF20","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0168-8278(96)80008-0","article-title":"Liver stellate cells in chronic viral hepatitis: The effect of interferon therapy","volume":"24","author":"Guido","year":"1996","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF21","first-page":"1100","article-title":"Balance between oxidative damage and proliferative potential in an experimental rat model of CCl4 induced cirrhosis: Protective role of adenosine administration","volume":"26","author":"Hernandez-Munoz","year":"1997","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1177\/019262338701500113","article-title":"Elevated lipid peroxidation in rats induced by dietary lipids and N-nitrosodimethylamine and its inhibition by indomethacin monitored via ethane exhalation","volume":"15","author":"Hietanen","year":"1987","journal-title":"Toxicol. Pathol."},{"key":"10.1006\/taap.2001.9234_RF23","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0168-8278(95)80420-X","article-title":"Improvement of liver fibrosis in chronic hepatitis C patients with natural interferon-\u03b1","volume":"22","author":"Hiramatsu","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1053\/gast.1997.v113.pm9322499","article-title":"A pilot study of the effects of d-\u03b1-tocopherol on hepatic stellate cell activation in chronic hepatitis C","volume":"113","author":"Houglum","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1006\/taap.2001.9234_RF25","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histologic grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal. Biochem."},{"key":"10.1006\/taap.2001.9234_RF27","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/0168-8278(90)90115-8","article-title":"Modulation of extracellular matrix components during dimethylnitrosamine-induced cirrhosis","volume":"11","author":"Jezequel","year":"1990","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF28","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0168-8278(87)80570-6","article-title":"A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat","volume":"5","author":"Jezequel","year":"1987","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF29","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/hep.1840160225","article-title":"Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis","volume":"16","author":"Kamimura","year":"1992","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF30","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1002\/hep.510270512","article-title":"Effect of antioxidants, resveratrol, quercetin, and N-acetylcysteine, on the functions of cultured rat hepatic stellate cells and Kupffer cells","volume":"27","author":"Kawada","year":"1998","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF31","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1136\/jcp.37.6.639","article-title":"Effects of fixation and enzymatic digestion on the immunohistochemical demostration of laminin and fibronectin in paraffin embedded tissue","volume":"37","author":"Kirkpatrick","year":"1984","journal-title":"Clin. Pathol."},{"key":"10.1006\/taap.2001.9234_RF32","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1172\/JCI118304","article-title":"Activation of hepatic stellate cells by TGF\u03b1 and collagen IIS mediated by oxidative stress through c-myb expression","volume":"96","author":"Lee","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1006\/taap.2001.9234_RF33","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/0076-6879(90)86141-H","article-title":"Determination of carbonyl content in oxidatively modified proteins","volume":"186","author":"Levine","year":"1990","journal-title":"Methods Enzymol."},{"key":"10.1006\/taap.2001.9234_RF34","first-page":"5328","article-title":"Alpha-interferon structure and natural killer cell stimulatory activity","volume":"50","author":"Li","year":"1990","journal-title":"Cancer Res."},{"key":"10.1006\/taap.2001.9234_RF35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.2001.9234_RF36","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1093\/nar\/12.5.2569","article-title":"Ascorbate stimulation of PAT cells causes an increase in transcription rates and a decrease in degradation rates of procollagen mRNA","volume":"12","author":"Lyon","year":"1984","journal-title":"Nucleic Acids Res."},{"key":"10.1006\/taap.2001.9234_RF37","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/hep.1840210418","article-title":"Interferon-\u03b1 and -\u03b3 inhibit proliferation and collagen synthesis of human ITO cells in culture","volume":"21","author":"Mallat","year":"1995","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF38","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/hep.1840180610","article-title":"Interferon alpha-2b therapy reduces liver fibrosis in chronic non-A, non-B hepatitis: A quantitative histological evaluation","volume":"18","author":"Manabe","year":"1993","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF39","first-page":"59","article-title":"Cellular localization of type I, III and IV procollagen gene transcripts in normal and fibrotic human liver","volume":"137","author":"Milani","year":"1990","journal-title":"Am. J. Pathol."},{"key":"10.1006\/taap.2001.9234_RF40","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/S0168-8278(96)80148-6","article-title":"Alpha-interferon prevents liver collagen deposition and damage induced by prolonged bile duct obstruction in the rat","volume":"24","author":"Muriel","year":"1996","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF41","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(98)00220-2","article-title":"Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride","volume":"15","author":"Muriel","year":"1998","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2001.9234_RF42","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/(SICI)1099-1263(200005\/06)20:3<189::AID-JAT632>3.0.CO;2-8","article-title":"Regulation of nitric oxide synthesis in the liver","volume":"3","author":"Muriel","year":"2000","journal-title":"J. Appl. Toxicol."},{"key":"10.1006\/taap.2001.9234_RF43","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0168-8278(94)80143-6","article-title":"Protective effect of S-adenosylmethionine on liver damage induced by biliary obstruction in rats: A histological, ultrastructural and biochemical study","volume":"21","author":"Muriel","year":"1994","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF44","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1016\/0270-9139(95)90630-4","article-title":"Sequential acetaldehyde production, lipid peroxidation and fibrogenesis in a micropig model of alcohol-induced liver disease","volume":"22","author":"Niemela","year":"1995","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF45","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2169\/internalmedicine.33.309","article-title":"Modulation of collagen synthesis and degradation by retinoids and cytokines in 3T3 L1 preadipocytes","volume":"33","author":"Numaguchi","year":"1994","journal-title":"Intern. Med."},{"key":"10.1006\/taap.2001.9234_RF46","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1136\/jcp.50.5.401","article-title":"In situ detection of lipid peroxidation in chronic hepatitis C: Correlation with pathological features","volume":"50","author":"Paradis","year":"1997","journal-title":"J. Clin. Pathol."},{"key":"10.1006\/taap.2001.9234_RF47","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1006\/bbrc.1993.1927","article-title":"Stimulation of lipid peroxidation or 4-hydroxynonenal treatment increases procollagen alpha 1(I) gene expression in human liver fat-storing cells","volume":"194","author":"Parola","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.2001.9234_RF48","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0168-8278(97)80183-3","article-title":"Antioxidant enzyme status in biliary obstructed rats: Effects of N-acetylcysteine","volume":"27","author":"Pastor","year":"1997","journal-title":"J. Hepatol."},{"key":"10.1006\/taap.2001.9234_RF49","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0300-5089(21)00116-4","article-title":"Fibrosis in chronic liver diseases","volume":"4","author":"Popper","year":"1975","journal-title":"Clin. Gastroenterol."},{"key":"10.1006\/taap.2001.9234_RF50","doi-asserted-by":"crossref","first-page":"517","DOI":"10.7326\/0003-4819-132-7-200004040-00002","article-title":"Histologic improvement of fibrosis in patients with hepatitis C who have sustained response to interferon therapy","volume":"132","author":"Shiratori","year":"2000","journal-title":"Ann. Intern. Med."},{"key":"10.1006\/taap.2001.9234_RF51","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1042\/bj1230805","article-title":"The stimulatory effect of carbon tetrachloride and other halogenoalkanes on peroxidative reactions in rat liver fractions in vitro","volume":"123","author":"Slater","year":"1971","journal-title":"Biochem. J."},{"key":"10.1006\/taap.2001.9234_RF52","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/S0016-5085(99)70135-6","article-title":"Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: A dynamic view. The Multivirc Group","volume":"116","author":"Sobesky","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1006\/taap.2001.9234_RF53","first-page":"95","article-title":"Morphological, immunohistochemical and ultrastructural changes in dimethylnitrosamine-induced liver injury. Effect of malotilate","volume":"4","author":"Stenback","year":"1989","journal-title":"Histol. Histopathol."},{"key":"10.1006\/taap.2001.9234_RF54","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/hep.1840220209","article-title":"Long-term decrease in serum N-terminal propeptide of type III procollagen in patients with chronic hepatitis C treated with interferon-\u03b1","volume":"22","author":"Suou","year":"1995","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF55","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/hep.510270313","article-title":"Fibrogenic effect of oxidative stress on rat hepatic stellate cells","volume":"27","author":"Svegliati Baroni","year":"1998","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF56","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/hep.1840190408","article-title":"Decrease in serum levels of markers of hepatic connective tissue turnover during and after treatment of chronic hepatitis B with interferon-\u03b1","volume":"19","author":"Teran","year":"1994","journal-title":"Hepatology"},{"key":"10.1006\/taap.2001.9234_RF57","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/0003-2697(69)90064-5","article-title":"Enzymic method for quantitative determination of nanogram amount of total and oxidized glutathione: Application to mammalian blood and other tissues","volume":"27","author":"Tietze","year":"1969","journal-title":"Anal. Biochem."},{"key":"10.1006\/taap.2001.9234_RF58","doi-asserted-by":"crossref","first-page":"407","DOI":"10.3109\/00365528909093067","article-title":"Effects of oral S-adenosyl-l-methionine on hepatic glutathione in patients with liver disease","volume":"24","author":"Vendemiale","year":"1989","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1006\/taap.2001.9234_RF59","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/med.2610150504","article-title":"Human leukocyte interferon alpha: Structure, pharmacology, and therapeutic applications","volume":"15","author":"Viscomi","year":"1995","journal-title":"Med. Res. Rev."},{"key":"10.1006\/taap.2001.9234_RF60","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1099\/0022-1317-57-1-233","article-title":"Comparison of the antiviral activities of various cloned human interferon-alpha subtypes in mammalian cell cultures","volume":"57","author":"Weck","year":"1981","journal-title":"J. Gen. Virol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01992348?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01992348?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T01:39:36Z","timestamp":1680572376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X01992348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,9]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,9]]}},"alternative-id":["S0041008X01992348"],"URL":"https:\/\/doi.org\/10.1006\/taap.2001.9234","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,9]]}}}