{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:20:49Z","timestamp":1772896849969,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,12,1]],"date-time":"2001-12-01T00:00:00Z","timestamp":1007164800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2001,12]]},"DOI":"10.1006\/taap.2001.9313","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:46:05Z","timestamp":1033933565000},"page":"232-237","source":"Crossref","is-referenced-by-count":4,"title":["Protection by Tetracyclines against Ion Transport Disruption Caused by Nystatin in Human Airway Epithelial Cells"],"prefix":"10.1006","volume":"177","author":[{"given":"Yasushi","family":"Ito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Nakayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Kume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Yamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2001.9313_RF1","doi-asserted-by":"crossref","first-page":"482","DOI":"10.7326\/0003-4819-85-4-482","article-title":"Minocycline","volume":"85","author":"Allen","year":"1976","journal-title":"Ann. Intern. Med."},{"key":"10.1006\/taap.2001.9313_RF2","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/jsre.1997.5202","article-title":"Acute effects of bile acids on the pancreatic duct epithelium in vitro","volume":"74","author":"Alvarez","year":"1998","journal-title":"J. Surg. Res."},{"key":"10.1006\/taap.2001.9313_RF3","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2174\/1381612013398031","article-title":"Lipid-based antifungal agents: Current status","volume":"7","author":"Arikan","year":"2001","journal-title":"Curr. Pharm. Des."},{"key":"10.1006\/taap.2001.9313_RF4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0005-2736(91)90200-R","article-title":"Effects of divalent cations and pH on amiloride-sensitive Na+ fluxes into luminal membrane vesicles from pars recta of rabbit proximal tubule","volume":"1068","author":"Blokkebak-Poulsen","year":"1991","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.2001.9313_RF5","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0304-4157(86)90002-X","article-title":"How do the polyene macrolide antibiotics affect the cellular membrane properties?","volume":"864","author":"Bolard","year":"1986","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.2001.9313_RF6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1126\/science.6322305","article-title":"Polyene toxicity in renal medulla: Injury mediated by transport activity","volume":"224","author":"Brezis","year":"1984","journal-title":"Science"},{"key":"10.1006\/taap.2001.9313_RF7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/B978-0-12-152511-8.50012-8","article-title":"Structure and mechanism of the (Na,K)-ATPase","volume":"11","author":"Cantley","year":"1981","journal-title":"Curr. Top. Bioenerg."},{"key":"10.1006\/taap.2001.9313_RF8","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/ki.1982.221","article-title":"Amphotericin B nephrotoxicity: Increased renal resistance and tubule permeability","volume":"22","author":"Cheng","year":"1982","journal-title":"Kidney Int."},{"key":"10.1006\/taap.2001.9313_RF9","first-page":"244","article-title":"Characteristics of amphotericin B-induced endothelial cell injury","volume":"121","author":"Cutaia","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"10.1006\/taap.2001.9313_RF10","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/jbmr.5650071111","article-title":"Regulation of cytoplasmic calcium concentration in tetracycline-treated osteoclast","volume":"7","author":"Donahue","year":"1992","journal-title":"J. Bone Miner. Res."},{"key":"10.1006\/taap.2001.9313_RF11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/0005-2736(82)90527-2","article-title":"Nystatin effects on cellular calcium in Saccharomyces cerevisiae","volume":"692","author":"Eilam","year":"1982","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1006\/taap.2001.9313_RF12","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/jps.2600650625","article-title":"Relationship between acute toxicity in mice and polymorphic forms of polyene antibiotics","volume":"65","author":"Ghielmetti","year":"1976","journal-title":"J. Pharm. Sci."},{"key":"10.1006\/taap.2001.9313_RF13","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1128\/AAC.25.3.354","article-title":"Influence of tetracyclines on human polymorphonuclear leukocyte function","volume":"25","author":"Glette","year":"1984","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1006\/taap.2001.9313_RF14","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0192-0561(86)90087-1","article-title":"Influence of tetracyclines and light on the release of lysozyme from human granulocytes and monocytes","volume":"8","author":"Glette","year":"1986","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1006\/taap.2001.9313_RF15","first-page":"H351","article-title":"Na+-K+-ATPase in endothelial cell energetics: 23Na nuclear magnetic resonance and calorimetry study","volume":"268","author":"Gruwel","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9313_RF16","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/infdis\/166.1.134","article-title":"Effect of cyclooxygenase inhibition on amphotericin B-induced lung injury in awake sheep","volume":"166","author":"Hardie","year":"1992","journal-title":"J. Infect. Dis."},{"key":"10.1006\/taap.2001.9313_RF17","doi-asserted-by":"crossref","first-page":"10319","DOI":"10.1016\/S0021-9258(19)68621-7","article-title":"Mitochondrial respiratory capacity and Na+- and K+-dependent adenosine triphosphatase-mediated ion transport in the intact renal cell","volume":"256","author":"Harris","year":"1981","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.2001.9313_RF18","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1007\/s004240050425","article-title":"The effect of brefeldin A on terbutaline-induced sodium absorption in fetal rat distal lung epithelium","volume":"434","author":"Ito","year":"1997","journal-title":"Pfl\u00fcgers Arch."},{"key":"10.1006\/taap.2001.9313_RF19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/bbrc.1999.0861","article-title":"Tetracyclines reduce Na+\/K+ pump capacity in Calu-3 human airway cells","volume":"260","author":"Ito","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1006\/taap.2001.9313_RF20","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/taap.2001.9261","article-title":"Novel effects of minocycline on Ca2+-dependent Cl\u2212 secretion in human airway epithelial Calu-3 cells","volume":"176","author":"Ito","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2001.9313_RF21","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1128\/JCM.26.12.2626-2631.1988","article-title":"In vitro susceptibilities and biotypes of Candida albicans isolates from the oral cavities of patients infected with human immunodeficiency virus","volume":"26","author":"Korting","year":"1988","journal-title":"J. Clin. Microbiol."},{"key":"10.1006\/taap.2001.9313_RF22","doi-asserted-by":"crossref","first-page":"664","DOI":"10.7326\/0003-4819-114-8-664","article-title":"Cardiopulmonary toxicity after liposomal amphotericin B infusion","volume":"114","author":"Levine","year":"1991","journal-title":"Ann. Intern. Med."},{"key":"10.1006\/taap.2001.9313_RF23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1085\/jgp.65.4.515","article-title":"Pores formed in lipid bilayer membranes by nystatin","volume":"65","author":"Marty","year":"1975","journal-title":"J. Gen. Physiol."},{"key":"10.1006\/taap.2001.9313_RF24","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1152\/jappl.1988.65.5.2195","article-title":"Role of oxidants, eicosanoids, and neutrophils in amphotericin B lung injury in rats","volume":"65","author":"McDonnell","year":"1988","journal-title":"J. Appl. Physiol."},{"key":"10.1006\/taap.2001.9313_RF25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1164\/ajrccm.154.1.8680677","article-title":"Trimethoprim and tetracycline inhibit airway epithelial sodium absorption","volume":"154","author":"Middleton","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1006\/taap.2001.9313_RF26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0020-1693(00)80959-7","article-title":"Chelates of tetracycline with first row transition metal perchlorates","volume":"144","author":"Mikulski","year":"1988","journal-title":"Morganica Chim. Acta"},{"key":"10.1006\/taap.2001.9313_RF27","first-page":"222","article-title":"Respiratory distress secondary to both amphotericin B deoxycholate and lipid complex formulation","volume":"42","author":"Rolland","year":"2000","journal-title":"Vet. Hum. Toxicol."},{"key":"10.1006\/taap.2001.9313_RF28","first-page":"L690","article-title":"Most basal Isc in Calu-3 human airway cells is bicarbonate-dependent Cl\u2212 secretion","volume":"272","author":"Singh","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9313_RF29","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1288\/00005537-198811000-00005","article-title":"In vitro effectiveness of 13 agents in otomycosis and review of the literature","volume":"98","author":"Stern","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1006\/taap.2001.9313_RF30","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0143-4160(97)90048-8","article-title":"Two distinct Na+ currents control cytosolic Ca2+ pulsing in Xenopus laevis pituitary melanotrophs","volume":"21","author":"Valentijn","year":"1997","journal-title":"Cell Calcium"},{"key":"10.1006\/taap.2001.9313_RF31","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1152\/jappl.1999.87.2.715","article-title":"Mechanical stretching of alveolar epithelial cells increases Na+-K+-ATPase activity","volume":"87","author":"Waters","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1006\/taap.2001.9313_RF32","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1128\/IAI.58.5.1296-1300.1990","article-title":"In vitro activation of macrophage oxidative burst activity by cytokines and amphotericin B","volume":"58","author":"Wolf","year":"1990","journal-title":"Infect. Immun."},{"key":"10.1006\/taap.2001.9313_RF33","first-page":"L485","article-title":"Ion transport by cultures of human tracheobronchial submucosal glands","volume":"261","author":"Yamaya","year":"1992","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2001.9313_RF34","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1038\/ki.1992.229","article-title":"Direct amphotericin B-mediated tubular toxicity: Assessments of selected cytoprotective agents","volume":"41","author":"Zager","year":"1992","journal-title":"Kidney Int."},{"key":"10.1006\/taap.2001.9313_RF35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1053\/ajkd.2000.8967","article-title":"Polyene antibiotics: Relative degrees of in vitro cytotoxicity and potential effects on tubule phospholipid and ceramide content","volume":"36","author":"Zager","year":"2000","journal-title":"Am. J. Kidney Dis."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01993135?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X01993135?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:08:44Z","timestamp":1622034524000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X01993135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,12]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,12]]}},"alternative-id":["S0041008X01993135"],"URL":"https:\/\/doi.org\/10.1006\/taap.2001.9313","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2001,12]]}}}