{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:46:59Z","timestamp":1791121619533,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2002,5]]},"DOI":"10.1006\/taap.2002.9394","type":"journal-article","created":{"date-parts":[[2002,9,18]],"date-time":"2002-09-18T22:01:25Z","timestamp":1032386485000},"page":"186-196","source":"Crossref","is-referenced-by-count":25,"title":["Anticoagulants Prevent Monocrotaline-Induced Hepatic Parenchymal Cell Injury but Not Endothelial Cell Injury in the Rat"],"prefix":"10.1006","volume":"180","author":[{"given":"Bryan L.","family":"Copple","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brook","family":"Woolley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Banes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia E.","family":"Ganey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2002.9394_RF1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/BF00254560","article-title":"Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital","volume":"19","author":"Ahmed","year":"1987","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1006\/taap.2002.9394_RF2","first-page":"279","article-title":"Hepatic veins of monkeys with veno-occlusive disease: Sequential ultrastructural changes","volume":"87","author":"Allen","year":"1969","journal-title":"Arch. Pathol."},{"key":"10.1006\/taap.2002.9394_RF3","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0041-008X(72)90049-X","article-title":"Modifications of pyrrolizidine alkaloid intoxication resulting from altered hepatic microsomal enzymes","volume":"23","author":"Allen","year":"1972","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9394_RF4","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1097\/00007890-199611270-00004","article-title":"Blood coagulation in the hepatic sinusoids as a contributing factor in liver injury following orthotopic liver transplantation in the rat","volume":"62","author":"Arai","year":"1996","journal-title":"Transplantation"},{"key":"10.1006\/taap.2002.9394_RF5","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1182\/blood.V79.11.2834.bloodjournal79112834","article-title":"Prevention of hepatic veno-occlusive disease after bone marrow transplantation by continuous infusion of low-dose heparin: A prospective, randomized trial","volume":"79","author":"Attal","year":"1992","journal-title":"Blood"},{"key":"10.1006\/taap.2002.9394_RF6","first-page":"268","article-title":"Effect of heparin, dermatan sulfate, and related oligo-derivatives on human polymorphonuclear leukocyte functions","volume":"121","author":"Bazzoni","year":"1993","journal-title":"J. Lab. Clin. Med."},{"key":"10.1006\/taap.2002.9394_RF7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/00001622-200003000-00001","article-title":"Veno-occlusive disease of the liver","volume":"12","author":"Bearman","year":"2000","journal-title":"Curr. Opin. Oncol."},{"key":"10.1006\/taap.2002.9394_RF8","first-page":"507","article-title":"Acute veno-occlusive disease of the liver: Fine structure in Jamaican children","volume":"89","author":"Brooks","year":"1970","journal-title":"Arch. Pathol."},{"key":"10.1006\/taap.2002.9394_RF9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/path.1711000305","article-title":"Lesions in the liver and lungs of rats given pyrrole derivatives of pyrrolizidine alkaloids","volume":"100","author":"Butler","year":"1970","journal-title":"J. Pathol."},{"key":"10.1006\/taap.2002.9394_RF10","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1034\/j.1600-0609.2000.9r200.x","article-title":"Veno-occlusive disease of the liver after hemopoietic cell transplantation","volume":"64","author":"Carreras","year":"2000","journal-title":"Eur. J. Haematol."},{"key":"10.1006\/taap.2002.9394_RF11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1093\/toxsci\/65.2.309","article-title":"Endothelial cell injury and fibrin deposition in rat liver after monocrotaline exposure","volume":"65","author":"Copple","year":"2002","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2002.9394_RF12","first-page":"A290","article-title":"Endotoxin-induced liver injury requires activation of protease-activated receptor-1","volume":"14","author":"Copple","year":"2000","journal-title":"FASEB J."},{"key":"10.1006\/taap.2002.9394_RF13","first-page":"351","article-title":"Neutrophils and monocrotaline-induced liver injury","volume":"60","author":"Copple","year":"2001","journal-title":"Toxicologist"},{"key":"10.1006\/taap.2002.9394_RF14","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/hep.1840190227","article-title":"Modulation of hepatic sinusiodal endothelial cell function by Kupffer cells: An example of intercellular communication in the liver","volume":"19","author":"Deaciuc","year":"1994","journal-title":"Hepatology"},{"key":"10.1006\/taap.2002.9394_RF15","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1111\/j.1530-0277.1993.tb05655.x","article-title":"Alcohol consumption in rats potentiates the deleterious effect of gram-negative sepsis on hepatic hyaluronan uptake","volume":"17","author":"Deaciuc","year":"1993","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1006\/taap.2002.9394_RF16","first-page":"1261","article-title":"Dacarbazine toxicity in murine liver cells: A model of hepatic endothelial injury and glutathione defense","volume":"268","author":"DeLeve","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2002.9394_RF17","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1002\/hep.510240414","article-title":"Cellular target of cyclophosphamide toxicity in the murine liver: Role of glutathione and site of metabolic activation","volume":"24","author":"DeLeve","year":"1996","journal-title":"Hepatology"},{"key":"10.1006\/taap.2002.9394_RF18","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1177\/030089160108700224","article-title":"Hepatic venoocclusive disease: A major complication of hematopoietic stem cell transplantation in cancer patients","volume":"87","author":"DeLeve","year":"2001","journal-title":"Tumori"},{"key":"10.1006\/taap.2002.9394_RF19","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1002\/hep.510290615","article-title":"Characterization of a reproducible rat model of hepatic veno-occlusive disease","volume":"29","author":"DeLeve","year":"1999","journal-title":"Hepatology"},{"key":"10.1006\/taap.2002.9394_RF20","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/hep.510230326","article-title":"Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: The role of glutathione and relevance to hepatic venoocclusive disease","volume":"23","author":"DeLeve","year":"1996","journal-title":"Hepatology"},{"key":"10.1006\/taap.2002.9394_RF21","first-page":"459","article-title":"Antibodies defining rat endothelial cells: RECA-1, a pan-endothelial cell-specific monoclonal antibody","volume":"66","author":"Duijvestijn","year":"1992","journal-title":"Lab. Invest."},{"key":"10.1006\/taap.2002.9394_RF22","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1136\/gut.29.8.1103","article-title":"Intravascular coagulation in acute liver failure in rats and its treatment with antithrombin III","volume":"29","author":"Fujiwara","year":"1988","journal-title":"Gut"},{"key":"10.1006\/taap.2002.9394_RF23","first-page":"53","article-title":"The coagulation system, but not circulating fibrinogen, contributes to liver injury in rats exposed to lipopolysaccharide from gram-negative bacteria","volume":"272","author":"Hewett","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2002.9394_RF24","series-title":"Toxicants of Plant Origin","first-page":"41","article-title":"Human health implications of pyrrolizidine alkaloids and herbs containing them","author":"Huxtable","year":"1989"},{"key":"10.1006\/taap.2002.9394_RF25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/taap.2000.9035","article-title":"Protection against TNF-induced liver parenchymal cell apoptosis during endotoxemia by a novel caspase inhibitor in mice","volume":"169","author":"Jaeschke","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9394_RF26","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/S0022-3468(99)90314-7","article-title":"Hyaluronic acid: A specific prognostic indicator of hepatic damage in biliary atresia","volume":"34","author":"Kobayashi","year":"1999","journal-title":"J. Pediatr. Surg."},{"key":"10.1006\/taap.2002.9394_RF27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/00001721-199710000-00001","article-title":"Veno-occlusive disease of the liver after bone marrow transplantation: Is hypercoagulability really part of the problem?","volume":"8","author":"Korte","year":"1997","journal-title":"Blood Coagul. Fibrinolysis"},{"key":"10.1006\/taap.2002.9394_RF28","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1177\/019262339902700419","article-title":"The nomenclature of cell death: Recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists","volume":"27","author":"Levin","year":"1999","journal-title":"Toxicol. Pathol."},{"key":"10.1006\/taap.2002.9394_RF29","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0003-2697(70)90478-1","article-title":"Estimation of metabolites of pyrrolizidine alkaloids in animal tissues","volume":"38","author":"Mattocks","year":"1970","journal-title":"Anal. Biochem."},{"key":"10.1006\/taap.2002.9394_RF30","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1055\/s-0038-1661157","article-title":"The inhibitory effect of heparin and related glycosaminoglycans on neutrophil chemotaxis","volume":"52","author":"Matzner","year":"1984","journal-title":"Thromb. Haemostasis"},{"key":"10.1006\/taap.2002.9394_RF31","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1182\/blood.V82.11.3253.3253","article-title":"Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation","volume":"82","author":"Nelson","year":"1993","journal-title":"Blood"},{"key":"10.1006\/taap.2002.9394_RF32","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1097\/00007890-199604150-00014","article-title":"Low molecular weight heparin for the prevention of veno-occlusive disease of the liver in bone marrow transplantation patients","volume":"61","author":"Or","year":"1996","journal-title":"Transplantation"},{"key":"10.1006\/taap.2002.9394_RF33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3109\/10715769009148576","article-title":"Heparin, a potent releasing agent of extracellular superoxide dismutase (EC-SOD C), suppresses ischaemic paw oedema in mice","volume":"9","author":"Oyanagui","year":"1990","journal-title":"Free Radical Res. Commun."},{"key":"10.1006\/taap.2002.9394_RF34","first-page":"378","article-title":"The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat","volume":"278","author":"Pearson","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1006\/taap.2002.9394_RF35","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1161\/01.RES.72.4.914","article-title":"Myocardial fibrin deposition in experimental viral myocarditis that progresses to dilated cardiomyopathy","volume":"72","author":"Schnitt","year":"1993","journal-title":"Circ. Res."},{"key":"10.1006\/taap.2002.9394_RF36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/bjc.1955.19","article-title":"Pathological changes in rats as a result of treatment with monocrotaline","volume":"9","author":"Schoental","year":"1955","journal-title":"Br. J. Cancer"},{"key":"10.1006\/taap.2002.9394_RF37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/10937409809524557","article-title":"Chronic pulmonary hypertension: The monocrotaline model and involvement of the hemostatic system","volume":"1","author":"Schultze","year":"1998","journal-title":"J. Toxicol. Environ. Health"},{"key":"10.1006\/taap.2002.9394_RF38","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/j.1875-9114.1997.tb03783.x","article-title":"A review of tissue plasminogen activator in the treatment of veno-occlusive liver disease after bone marrow transplantation","volume":"17","author":"Terra","year":"1997","journal-title":"Pharmacotherapy"},{"key":"10.1006\/taap.2002.9394_RF39","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/hep.510310224","article-title":"Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat","volume":"31","author":"Wang","year":"2000","journal-title":"Hepatology"},{"key":"10.1006\/taap.2002.9394_RF40","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.2000.8968","article-title":"Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline","volume":"166","author":"Yee","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9394_RF41","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/ajh.2830460307","article-title":"Recombinant tissue plasminogen activator (rt-PA) for veno-occlusive liver disease in pediatric autologous bone marrow transplant patients","volume":"46","author":"Yu","year":"1994","journal-title":"Am. J. Hematol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X02993944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X02993944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,12,30]],"date-time":"2023-12-30T03:47:05Z","timestamp":1703908025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X02993944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,5]]}},"alternative-id":["S0041008X02993944"],"URL":"https:\/\/doi.org\/10.1006\/taap.2002.9394","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}