{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:13:30Z","timestamp":1776118410260,"version":"3.50.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2002,6,1]],"date-time":"2002-06-01T00:00:00Z","timestamp":1022889600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2002,6]]},"DOI":"10.1006\/taap.2002.9419","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T18:49:14Z","timestamp":1033930154000},"page":"228-232","source":"Crossref","is-referenced-by-count":22,"title":["Hypochlorous Acid Is a Potent Inhibitor of Acetylcholinesterase"],"prefix":"10.1006","volume":"181","author":[{"given":"Gertjan J.M.","family":"den Hartog","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Vegt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wim J.F.","family":"van der Vijgh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido R.M.M.","family":"Haenen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aalt","family":"Bast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2002.9419_RF1","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1164\/ajrccm.160.supplement_1.17","article-title":"Novel approaches and targets for treatment chronic obstructive pulmonary disease","volume":"160","author":"Barnes","year":"1999","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1006\/taap.2002.9419_RF2","doi-asserted-by":"crossref","first-page":"2s","DOI":"10.1016\/0002-9343(91)90278-6","article-title":"Oxidants and antioxidants: State of the art","volume":"91","author":"Bast","year":"1991","journal-title":"Am. J. Med."},{"key":"10.1006\/taap.2002.9419_RF3","first-page":"144","article-title":"Effects of dihydrolipoic acid on peptide methionine sulfoxide reductase. Implications for antioxidant drugs","volume":"48","author":"Biewenga","year":"1998","journal-title":"Arzneimittelforschung"},{"key":"10.1006\/taap.2002.9419_RF4","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0034-5687(00)00208-5","article-title":"Neural regulation of airway smooth muscle tone","volume":"125","author":"Canning","year":"2001","journal-title":"Respir. Physiol."},{"key":"10.1006\/taap.2002.9419_RF5","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1034\/j.1399-3003.2000.15d11.x","article-title":"Effects of inhaled steroids on methacholine-induced bronchoconstriction and gas trapping in mild asthma","volume":"15","author":"Corsico","year":"2000","journal-title":"Eur. Respir. J."},{"key":"10.1006\/taap.2002.9419_RF6","first-page":"861","article-title":"Eosinophils and airway nerves in asthma","volume":"15","author":"Costello","year":"2000","journal-title":"Histol. Histopathol."},{"key":"10.1006\/taap.2002.9419_RF7","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.2042-7158.1990.tb07035.x","article-title":"Regulation of sympathetic and parasympathetic receptor responses in the rat trachea by epithelium: Influence of mechanical and chemical removal of epithelium","volume":"42","author":"Doelman","year":"1990","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1006\/taap.2002.9419_RF8","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2002.9419_RF9","first-page":"L593","article-title":"Cigarette smoking, emphysema, and damage to alpha 1-proteinase inhibitor","volume":"266","author":"Evans","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2002.9419_RF10","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1378\/chest.118.5.1397","article-title":"Airway hyperreactivity in subjects with tetraplegia is associated with reduced baseline airway caliber","volume":"118","author":"Grimm","year":"2000","journal-title":"Chest"},{"key":"10.1006\/taap.2002.9419_RF11","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1016\/0006-2952(91)90363-A","article-title":"Scavenging of hypochlorous acid by lipoic acid","volume":"42","author":"Haenen","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2002.9419_RF12","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1182\/blood.V92.9.3007","article-title":"Inside the neutrophil phagosome: Oxidants, myeloperoxidase, and bacterial killing","volume":"92","author":"Hampton","year":"1998","journal-title":"Blood"},{"key":"10.1006\/taap.2002.9419_RF13","first-page":"H1505","article-title":"Loss of GSH and thiol enzymes in endothelial cells exposed to sublethal concentrations of hypochlorous acid","volume":"277","author":"Pullar","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1006\/taap.2002.9419_RF14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0009-2797(97)00047-1","article-title":"A comparative QSAR analysis of acetylcholinesterase inhibitors currently studied for the treatment of Alzheimer's disease","volume":"105","author":"Recanatini","year":"1997","journal-title":"Chem. Biol. Interact."},{"key":"10.1006\/taap.2002.9419_RF15","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1164\/ajrccm.156.2.9611013","article-title":"Oxidative stress in chronic obstructive pulmonary disease. Oxidative Stress Study Group","volume":"156","author":"Repine","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1006\/taap.2002.9419_RF16","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1164\/ajrccm.153.5.8630623","article-title":"Peroxynitrite induces airway hyperresponsiveness in guinea pigs in vitro and in vivo","volume":"153","author":"Sadeghi-Hashjin","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1006\/taap.2002.9419_RF17","first-page":"3","article-title":"Changes in receptor function by oxidative stress in guinea pig tracheal smooth muscle","volume":"4","author":"van Hoof","year":"1996","journal-title":"Cent. Eur. J. Public Health"}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X02994196?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X02994196?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,5]],"date-time":"2020-03-05T13:05:04Z","timestamp":1583413504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X02994196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,6]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,6]]}},"alternative-id":["S0041008X02994196"],"URL":"https:\/\/doi.org\/10.1006\/taap.2002.9419","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,6]]}}}