{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:36:16Z","timestamp":1791902176668,"version":"4.3.4"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2002,7,1]],"date-time":"2002-07-01T00:00:00Z","timestamp":1025481600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxicology and Applied Pharmacology"],"published-print":{"date-parts":[[2002,7]]},"DOI":"10.1006\/taap.2002.9420","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:53:18Z","timestamp":1033933998000},"page":"44-54","source":"Crossref","is-referenced-by-count":309,"title":["Induction and Inhibition of Aromatase (CYP19) Activity by Various Classes of Pesticides in H295R Human Adrenocortical Carcinoma Cells"],"prefix":"10.1006","volume":"182","author":[{"given":"J.Thomas","family":"Sanderson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"Boerma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon W.A.","family":"Lansbergen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1006\/taap.2002.9420_RF1","doi-asserted-by":"crossref","first-page":"3843","DOI":"10.1210\/jc.81.11.3843","article-title":"Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients","volume":"81","author":"Agarwal","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/taap.2002.9420_RF2","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","article-title":"Genistein, a specific inhibitor of tyrosine-specific protein kinases","volume":"262","author":"Akiyama","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1006\/taap.2002.9420_RF3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0022-4731(88)90207-5","article-title":"Structure-activity relationships of the inhibition of human placental aromatase by imidazole drugs including ketoconazole","volume":"31","author":"Ayub","year":"1988","journal-title":"J. Steroid Biochem."},{"key":"10.1006\/taap.2002.9420_RF4","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1289\/ehp.011091063","article-title":"Antiandrogenic pesticides disrupt sexual characteristics in the adult male guppy (Poecilia reticulata)","volume":"109","author":"Baatrup","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1006\/taap.2002.9420_RF5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0378-4274(85)90046-3","article-title":"Toxicity determined in vitro by morphological alterations and neutral red absorption","volume":"24","author":"Borenfreund","year":"1985","journal-title":"Toxicol. Lett."},{"key":"10.1006\/taap.2002.9420_RF6","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S1043-2760(01)00529-X","article-title":"Aromatase inhibitors in breast cancer","volume":"13","author":"Brodie","year":"2002","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1006\/taap.2002.9420_RF7","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1210\/endo-100-6-1684","article-title":"The effect of an aromatase inhibitor, 4-hydroxy-4-androstene-3,17-dione, on estrogen-dependent processes in reproduction and breast cancer","volume":"100","author":"Brodie","year":"1977","journal-title":"Endocrinology"},{"key":"10.1006\/taap.2002.9420_RF8","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00682738","article-title":"Regulation of aromatase expression in human tissues","volume":"30","author":"Bulun","year":"1994","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1006\/taap.2002.9420_RF9","first-page":"583","article-title":"Ethoxyresorufin: Direct fluorometric assay of a microsomal O-dealkylation which is preferentially inducible by 3-methylcholanthrene","volume":"2","author":"Burke","year":"1974","journal-title":"Drug Metab. Dispos."},{"key":"10.1006\/taap.2002.9420_RF10","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1677\/erc.0.0060149","article-title":"Breast tumor aromatase: Functional role and transcriptional regulation","volume":"6","author":"Chen","year":"1999","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1006\/taap.2002.9420_RF11","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0960-0760(01)00132-7","article-title":"Modulation of aromatase expression in human breast tissue","volume":"79","author":"Chen","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1006\/taap.2002.9420_RF12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0960-0760(96)00047-7","article-title":"Paradoxical effect of an aromatase inhibitor, CGS 20267, on aromatase activity in guinea pig brain","volume":"58","author":"Choate","year":"1996","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1006\/taap.2002.9420_RF13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0039-128X(96)00246-2","article-title":"The estrogenic and antiestrogenic activities of phytochemicals with the human estrogen receptor expressed in yeast","volume":"62","author":"Collins","year":"1997","journal-title":"Steroids"},{"key":"10.1006\/taap.2002.9420_RF14","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","article-title":"Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability","volume":"89","author":"Denizot","year":"1986","journal-title":"J. Immunol. Methods"},{"key":"10.1006\/taap.2002.9420_RF15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449609089891","article-title":"Ecotoxicology of organotin compounds","volume":"26","author":"Fent","year":"1996","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1006\/taap.2002.9420_RF16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0166-445X(91)90014-Z","article-title":"Effects of tributyltin chloride in vitro on the hepatic microsomal monooxygenase system in the fish Stenomus chrysops","volume":"20","author":"Fent","year":"1991","journal-title":"Aquat. Toxicol."},{"key":"10.1006\/taap.2002.9420_RF17","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0166-445X(93)90073-A","article-title":"Effects of tributyltin in vivo on hepatic cytochrome P450 forms in marine fish","volume":"24","author":"Fent","year":"1993","journal-title":"Aquat. Toxicol."},{"key":"10.1006\/taap.2002.9420_RF18","first-page":"277","article-title":"Effects of triphenyltin and other organotins on hepatic monooxygenase system in fish","volume":"121","author":"Fent","year":"1998","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1006\/taap.2002.9420_RF19","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0960-0760(99)00144-2","article-title":"Estrogen synthesis in human colon cancer epithelial cells","volume":"71","author":"Fiorelli","year":"1999","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1006\/taap.2002.9420_RF20","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0041-008X(87)90104-9","article-title":"Inhibition of central nervous system aromatase activity: A mechanism for fenarimol-induced infertility in the male rat","volume":"91","author":"Hirsch","year":"1987","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9420_RF21","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1289\/ehp.9810685","article-title":"Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study","volume":"106","author":"Kao","year":"1998","journal-title":"Environ. Health Perspect."},{"key":"10.1006\/taap.2002.9420_RF22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1006\/taap.1996.7966","article-title":"Vinclozolin and p,p\u2032-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanism","volume":"142","author":"Kelce","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9420_RF23","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1007\/s001090050104","article-title":"Environmental antiandrogens: Developmental effects, molecular mechanisms, and clinical implications","volume":"75","author":"Kelce","year":"1997","journal-title":"J. Mol. Med."},{"key":"10.1006\/taap.2002.9420_RF24","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/0006-2952(92)90531-M","article-title":"Effects of flavonoids on cyclic AMP phosphodiesterase and lipid mobilization in rat adipocytes","volume":"44","author":"Kuppusamy","year":"1992","journal-title":"Biochem. Pharmacol."},{"key":"10.1006\/taap.2002.9420_RF25","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0304-3835(98)00141-4","article-title":"Estrogenic and antiproliferative activities on MCF-7 human breast cancer cells by flavonoids","volume":"130","author":"Le Bail","year":"1998","journal-title":"Cancer Lett."},{"key":"10.1006\/taap.2002.9420_RF26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0303-7207(96)03968-8","article-title":"Pesticides: Multiple mechanisms of demasculization","volume":"126","author":"LeBlanc","year":"1997","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1006\/taap.2002.9420_RF27","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/0076-6879(91)06116-K","article-title":"Assay of aromatase activity","volume":"206","author":"Lephart","year":"1991","journal-title":"Methods Enzymol."},{"key":"10.1006\/taap.2002.9420_RF28","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0968-0896(98)00266-1","article-title":"Phosphodiesterase 4 inhibitors as airways smooth muscle relaxant agents: synthesis and biological activities of triazine derivatives","volume":"7","author":"Leroux","year":"1999","journal-title":"Bioorg. Med. Chem."},{"key":"10.1006\/taap.2002.9420_RF29","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/taap.1999.8746","article-title":"Cytotoxicity and aromatase (CYP19) activity modulation by organochlorines in human placental JEG-3 and JAR choriocarcinoma cells","volume":"160","author":"Letcher","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9420_RF30","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1210\/endo-103-5-1860","article-title":"Phytoestrogen interaction with estrogen receptors in human breast cancer cells","volume":"103","author":"Martin","year":"1978","journal-title":"Endocrinology"},{"key":"10.1006\/taap.2002.9420_RF31","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0039-128X(83)90070-3","article-title":"Imidazole antimycotics: Selective inhibitors of steroid aromatization and progesterone hydroxylation","volume":"50","author":"Mason","year":"1987","journal-title":"Steroids"},{"key":"10.1006\/taap.2002.9420_RF32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1210\/edrv-9-3-295","article-title":"Molecular biology of steroid hormone synthesis","volume":"9","author":"Miller","year":"1988","journal-title":"Endocr. Rev."},{"key":"10.1006\/taap.2002.9420_RF33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0141-1136(93)90030-4","article-title":"Inhibition of ovarian microsomal aromatase and follicular oestradiol secretion by imidazole fungicides in rainbow trout","volume":"35","author":"Monod","year":"1993","journal-title":"Mar. Environ. Res."},{"key":"10.1006\/taap.2002.9420_RF34","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1006\/enrs.1999.4002","article-title":"Evidence of endocrine disruption in the imposex-affected gastropod Bolinus brandaris","volume":"81","author":"Morcillo","year":"1999","journal-title":"Environ. Res."},{"key":"10.1006\/taap.2002.9420_RF35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3109\/14756369709035817","article-title":"Inhibition and inactivation of equine aromatase by steroidal and non-steroidal compounds. A comparison with human aromatase inhibition","volume":"12","author":"Moslemi","year":"1997","journal-title":"J. Enzyme Inhib."},{"key":"10.1006\/taap.2002.9420_RF36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1749-6632.2001.tb03988.x","article-title":"Peptide hormones versus steroid hormones: Case studies from snail and turtle populations","volume":"948","author":"Oberdorster","year":"2001","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1006\/taap.2002.9420_RF37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0960-0760(95)00261-8","article-title":"Effects of flavonoids on aromatase activity, an in vitro study","volume":"57","author":"Pelissero","year":"1996","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1006\/taap.2002.9420_RF38","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0303-7207(94)90277-1","article-title":"The NCI-H295 cell line: A pluripotent model for human adrenocortical studies","volume":"100","author":"Rainey","year":"1994","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1006\/taap.2002.9420_RF39","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1210\/jc.77.3.731","article-title":"Regulation of human adrenal carcinoma cell (NCI-H295) production of C19 steroids","volume":"77","author":"Rainey","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1006\/taap.2002.9420_RF40","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1289\/ehp.011091027","article-title":"Effects of chloro-s-triazine herbicides and metabolites on aromatase activity in various human cell lines and on vitellogenin production in male carp hepatocytes","volume":"109","author":"Sanderson","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1006\/taap.2002.9420_RF41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/toxsci\/54.1.121","article-title":"2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity in H295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity?","volume":"54","author":"Sanderson","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2002.9420_RF42","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/toxsci\/61.1.40","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and diindolylmethanes differentially induce cytochrome P450 1A1, 1B1 and 19 in H295R human adrenocortical carcinoma cells","volume":"61","author":"Sanderson","year":"2001","journal-title":"Toxicol. Sci."},{"key":"10.1006\/taap.2002.9420_RF43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1677\/erc.0.0060075","article-title":"Use of aromatase inhibitors in breast carcinoma","volume":"6","author":"Santen","year":"1999","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1006\/taap.2002.9420_RF44","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0960-0760(93)90235-O","article-title":"Tissue-specific promoters regulate aromatase cytochrome P450 expression","volume":"44","author":"Simpson","year":"1993","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1006\/taap.2002.9420_RF45","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1210\/me.7.3.423","article-title":"Regulation of steroidogenesis in NCI-H295 cells: A cellular model of the human fetal adrenal","volume":"7","author":"Staels","year":"1993","journal-title":"Mol. Endocrinol."},{"key":"10.1006\/taap.2002.9420_RF46","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1126\/science.178.4063.871","article-title":"Fluorescamine: A reagent for assay of amino acids, peptides, proteins, and primary amines in the picomole range","volume":"178","author":"Udenfriend","year":"1972","journal-title":"Science"},{"key":"10.1006\/taap.2002.9420_RF47","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0887-2333(00)00018-7","article-title":"Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro","volume":"14","author":"Vinggaard","year":"2000","journal-title":"Toxicol. In Vitro"},{"key":"10.1006\/taap.2002.9420_RF48","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1021\/bi00337a023","article-title":"Regulation of rat hepatic cytochrome P-450: Age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes","volume":"24","author":"Waxman","year":"1985","journal-title":"Biochemistry"},{"key":"10.1006\/taap.2002.9420_RF49","first-page":"1017","article-title":"Screening of potential cancer preventing chemicals as aromatase inhibitors in an in vitro assay","volume":"19","author":"White","year":"1999","journal-title":"Anticancer Res."},{"key":"10.1006\/taap.2002.9420_RF50","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1006\/taap.1999.8694","article-title":"Modulation of testosterone-metabolizing hepatic cytochrome P-450 enzymes in developing Sprague-Dawley rats following in utero exposure to p,p\u2032-DDE","volume":"158","author":"You","year":"1999","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1006\/taap.2002.9420_RF51","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0303-7207(01)00445-2","article-title":"Induction of hepatic aromatase by p,p\u2032-DDE in adult male rats","volume":"178","author":"You","year":"2001","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1006\/taap.2002.9420_RF52","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0960-0760(97)00072-1","article-title":"Mechanisms of the actions of aromatase inhibitors 4-hydroxyandrostenedione, fadrozole, and aminoglutethimide on aromatase in JEG-3 cell culture","volume":"63","author":"Yue","year":"1997","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1006\/taap.2002.9420_RF53","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0960-0760(97)80023-4","article-title":"Gene regulation studies of aromatase expression in breast cancer and adipose stromal cells","volume":"61","author":"Zhou","year":"1997","journal-title":"J. Steroid Biochem. Mol. Biol."}],"container-title":["Toxicology and Applied Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X02994202?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0041008X02994202?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T13:09:25Z","timestamp":1622034565000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0041008X02994202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,7]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,7]]}},"alternative-id":["S0041008X02994202"],"URL":"https:\/\/doi.org\/10.1006\/taap.2002.9420","relation":{},"ISSN":["0041-008X"],"issn-type":[{"value":"0041-008X","type":"print"}],"subject":[],"published":{"date-parts":[[2002,7]]}}}