{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T15:41:07Z","timestamp":1770738067504,"version":"3.49.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1998,5,1]],"date-time":"1998-05-01T00:00:00Z","timestamp":893980800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T00:00:00Z","timestamp":1374019200000},"content-version":"vor","delay-in-days":5556,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Virology"],"published-print":{"date-parts":[[1998,5]]},"DOI":"10.1006\/viro.1998.9128","type":"journal-article","created":{"date-parts":[[2002,10,6]],"date-time":"2002-10-06T19:24:08Z","timestamp":1033932248000},"page":"352-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Mice Expressing the E7 Oncogene of HPV16 in Epithelium Show Central Tolerance, and Evidence of Peripheral Anergising Tolerance, to E7-Encoded Cytotoxic T-Lymphocyte Epitopes"],"prefix":"10.1006","volume":"244","author":[{"given":"Tracy","family":"Doan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melita","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Street","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Germain J.P.","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Herd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Tindle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1006\/viro.1998.9128_VY989128RF1","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/S0959-8049(05)80047-4","article-title":"Definition of immunogenic determinants of the human papillomavirus type 16 nucleoprotein E7","volume":"28","author":"Altmann","year":"1992","journal-title":"Eur. J. Cancer"},{"key":"10.1006\/viro.1998.9128_VY989128RF2","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1128\/jvi.68.7.4358-4368.1994","article-title":"Progressive squamous epithelial neoplasia in K14-human papillomavirus type 16 transgenic mice","volume":"68","author":"Arbeit","year":"1994","journal-title":"J. Virol."},{"key":"10.1006\/viro.1998.9128_VY989128RF3","first-page":"8250","article-title":"Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors","volume":"14","author":"Auewarakul","year":"1994","journal-title":"Mol. Cell Biol."},{"key":"10.1006\/viro.1998.9128_VY989128RF4","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/eji.1830200904","article-title":"Antigen presentation by keratinocytes induces tolerance in human T cells","volume":"20","author":"Bal","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF5","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1002\/eji.1830250721","article-title":"Peripheral deletion of autoreactive CD8+b","volume":"25","author":"Bertolino","year":"1995","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF6","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1128\/jcm.29.8.1579-1588.1991","article-title":"Human papillomavirus type 18 E6 and E7 antibodies in human sera: Increased anti-E7 prevalence in cervical cancer patients","volume":"29","author":"Bleul","year":"1991","journal-title":"J. Clin. Microbiol."},{"key":"10.1006\/viro.1998.9128_VY989128RF7","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/S0140-6736(96)90674-1","article-title":"A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer [see comments]","volume":"347","author":"Borysiewicz","year":"1996","journal-title":"Lancet"},{"key":"10.1006\/viro.1998.9128_VY989128RF8","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1093\/jnci\/87.11.796","article-title":"Prevalence of human papillomavirus in cervical cancer: A worldwide perspective. International biological study on cervical cancer (IBSCC) Study Group [see comments]","volume":"87","author":"Bosch","year":"1995","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1006\/viro.1998.9128_VY989128RF9","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1073\/pnas.90.14.6523","article-title":"Metastatic conversion of cells by expression of human papillomavirus type 16 E6 and E7 genes","volume":"90","author":"Chen","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/viro.1998.9128_VY989128RF10","first-page":"1899","article-title":"Genetic predisposition and parameters of malignant progression in K14-HPV16 transgenic mice","volume":"149","author":"Coussens","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1006\/viro.1998.9128_VY989128RF11","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0923-2494(96)80265-3","article-title":"Simple developmental programs of gene expression and cellular composition of lymphoid organs at the origin of natural tolerance","volume":"146","author":"Coutinho","year":"1995","journal-title":"Res. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF12","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4049\/jimmunol.155.3.1023","article-title":"Anatomical environment as a determinant in viral immunity","volume":"155","author":"Doherty","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF13","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1006\/viro.1997.8650","article-title":"Presentation of the HPV16E7 protein by skin grafts is sufficient to allow graft rejection in an E7-primed animal","volume":"235","author":"Dunn","year":"1997","journal-title":"Virology"},{"key":"10.1006\/viro.1998.9128_VY989128RF14","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1002\/eji.1830230929","article-title":"Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells","volume":"23","author":"Feltkamp","year":"1993","journal-title":"Eur J Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF15","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/0264-410X(95)00029-Z","article-title":"Peptide polymerisation facilitates incorporation into ISCOMS, and increases antigen-specific IgG2a","volume":"13\/15","author":"Fernando","year":"1995","journal-title":"Vaccine"},{"key":"10.1006\/viro.1998.9128_VY989128RF16","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0008-8749(90)90217-F","article-title":"Effect of iscoms and their adjuvant moiety (matrix) on the initial proliferation and IL-2 responses: Comparison of spleen cells from mice inoculated with iscoms and\/or matrix","volume":"129","author":"Fossum","year":"1990","journal-title":"Cell Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF17","first-page":"2635","article-title":"Immunological responses in human papillomavirus 16 E6\/E7-transgenic mice to E7 protein correlate with the presence of skin disease","volume":"55","author":"Frazer","year":"1995","journal-title":"Cancer Res."},{"key":"10.1006\/viro.1998.9128_VY989128RF18","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/326881a0","article-title":"Cytotoxic T lymphocytes recognise a fragment of fluenza virus matrix protein in association with HLA.A2","volume":"326","author":"Gotch","year":"1987","journal-title":"Nature"},{"key":"10.1006\/viro.1998.9128_VY989128RF19","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1128\/jvi.67.3.1373-1384.1993","article-title":"Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation","volume":"67","author":"Griep","year":"1993","journal-title":"J. Virol."},{"key":"10.1006\/viro.1998.9128_VY989128RF20","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1128\/jvi.70.3.1873-1881.1996","article-title":"Squamous epithelial hyperplasia and carcinoma in mice transgenic for the human papillomavirus type 16 E7 oncogene","volume":"70","author":"Herber","year":"1996","journal-title":"J. Virol."},{"key":"10.1006\/viro.1998.9128_VY989128RF21","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/viro.1997.8491","article-title":"E7 oncoprotein of human papillomavirus type 16 expressed constitutively in the epidermis has no effect on E7-specific B-or Th-repertoires or on the immune response induced or sustained after immunization with E7 protein","volume":"231","author":"Herd","year":"1997","journal-title":"Virology"},{"key":"10.1006\/viro.1998.9128_VY989128RF22","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1073\/pnas.89.7.2526","article-title":"Tolerance induction by thymic medullary epithelium","volume":"89","author":"Hoffmann","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/viro.1998.9128_VY989128RF23","doi-asserted-by":"crossref","first-page":"9851","DOI":"10.1073\/pnas.92.21.9851","article-title":"Deletion of high-avidity T cells by thymic epithelium","volume":"92","author":"Hoffmann","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/viro.1998.9128_VY989128RF24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/374068a0","article-title":"Immunological function of a defined T-cell population tolerized to low-affinity self antigens [published erratum appears in Nature 1995 Nov 23;378(6555):419]","volume":"374","author":"Kawai","year":"1995","journal-title":"Nature"},{"key":"10.1006\/viro.1998.9128_VY989128RF25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/383081a0","article-title":"Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex","volume":"383","author":"Laufer","year":"1996","journal-title":"Nature"},{"key":"10.1006\/viro.1998.9128_VY989128RF26","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1128\/jvi.71.5.3998-4004.1997","article-title":"Immunological ignorance of an E7-encoded cytolytic T-lymphocyte epitope in transgenic mice expressing the E7 and E6 oncogenes of human papillomavirus type 16","volume":"71","author":"Melero","year":"1997","journal-title":"J. Virol."},{"key":"10.1006\/viro.1998.9128_VY989128RF27","first-page":"159","article-title":"T cell tolerance and autoimmunity","volume":"204","author":"Miller","year":"1997","journal-title":"Ciba Found. Symp."},{"key":"10.1006\/viro.1998.9128_VY989128RF28","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/eji.1830260822","article-title":"Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epithelium","volume":"26","author":"Modigliani","year":"1996","journal-title":"Eur. J. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0092-8674(88)91043-4","article-title":"Introduction of soluble protein into class 1 pathway of antigen processing and presentation","volume":"54","author":"Moore","year":"1988","journal-title":"Cell"},{"key":"10.1006\/viro.1998.9128_VY989128RF30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jcb.240590908","article-title":"The molecular biology of cervical cancer","volume":"23","author":"Munger","year":"1995","journal-title":"J. Cell Biochem."},{"key":"10.1006\/viro.1998.9128_VY989128RF31","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/cimm.1994.1281","article-title":"Escape of thymocytes and mature T cells from clonal deletion due to limiting tolerogen expression levels","volume":"158","author":"Oehen","year":"1994","journal-title":"Cell. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF32","doi-asserted-by":"crossref","first-page":"5934","DOI":"10.4049\/jimmunol.154.11.5934","article-title":"Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides","volume":"154","author":"Ressing","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF33","first-page":"582","article-title":"Occasional memory cytotoxic T-cell responses of patients with human papillomavirus type 16-positive cervical lesions against a human leukocyte antigen-A *0201-restricted E7-encoded epitope","volume":"56","author":"Ressing","year":"1996","journal-title":"Cancer Res."},{"key":"10.1006\/viro.1998.9128_VY989128RF34","doi-asserted-by":"crossref","first-page":"5887","DOI":"10.1073\/pnas.88.13.5887","article-title":"A \u2018public\u2018 T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes","volume":"88","author":"Tindle","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1006\/viro.1998.9128_VY989128RF35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2249.1995.tb08349.x","article-title":"A vaccine conjugate of 'SCAR\u2019 immunocarrier and peptide epitopes of the E7 cervical cancer-associated protein of human papillomavirus type 16 elicits specific Th1- and Th2-type responses in immunized mice in the absence of oil-based adjuvants","volume":"101","author":"Tindle","year":"1995","journal-title":"Clin. Exp. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF36","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0952-7915(96)80080-X","article-title":"Vaccines for cervical cancer","volume":"8","author":"Tindle","year":"1996","journal-title":"Curr. Opin. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF37","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.4049\/jimmunol.154.11.6013","article-title":"Recruitment and proliferation of CD8+ T cells in respiratory virus infections","volume":"154","author":"Tripp","year":"1995","journal-title":"J. Immunol."},{"key":"10.1006\/viro.1998.9128_VY989128RF38","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1084\/jem.173.4.1007","article-title":"Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex","volume":"173","author":"Vitiello","year":"1991","journal-title":"J. Exp. Med."},{"key":"10.1006\/viro.1998.9128_VY989128RF39","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1084\/jem.180.5.1901","article-title":"Thymic selection and adaptability of cytotoxic T lymphocyte responses in transgenic mice expressing a viral protein in the thymus","volume":"180","author":"von Herrath","year":"1994","journal-title":"J. Exp. Med."},{"key":"10.1006\/viro.1998.9128_VY989128RF40","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1128\/jvi.68.5.2811-2821.1994","article-title":"Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: Consequences for the phenotype and E6-p53 and E7-pRB interactions","volume":"68","author":"von Knebel Doeberitz","year":"1994","journal-title":"J. Virol."}],"container-title":["Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682298991280?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0042682298991280?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T23:04:19Z","timestamp":1758582259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0042682298991280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,5]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,5]]}},"alternative-id":["S0042682298991280"],"URL":"https:\/\/doi.org\/10.1006\/viro.1998.9128","relation":{},"ISSN":["0042-6822"],"issn-type":[{"value":"0042-6822","type":"print"}],"subject":[],"published":{"date-parts":[[1998,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mice Expressing the E7 Oncogene of HPV16 in Epithelium Show Central Tolerance, and Evidence of Peripheral Anergising Tolerance, to E7-Encoded Cytotoxic T-Lymphocyte Epitopes","name":"articletitle","label":"Article Title"},{"value":"Virology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1006\/viro.1998.9128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1998 Academic Press. All rights reserved.","name":"copyright","label":"Copyright"}]}}