{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T23:51:53Z","timestamp":1773100313140,"version":"3.50.1"},"publisher-location":"New York, NY","reference-count":53,"publisher":"Springer New York","isbn-type":[{"value":"9780387308319","type":"print"},{"value":"9780387337784","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/0-387-33778-4_11","type":"book-chapter","created":{"date-parts":[[2007,2,25]],"date-time":"2007-02-25T13:46:08Z","timestamp":1172411168000},"page":"168-176","source":"Crossref","is-referenced-by-count":19,"title":["Alterations of Mesenchymal and Endothelial Cells in Inflammatory Bowel Diseases"],"prefix":"10.1007","author":[{"given":"Claudio","family":"Fiocchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Ina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Z. A.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon D.","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"11_CR1","doi-asserted-by":"crossref","first-page":"908","DOI":"10.7326\/0003-4819-136-12-200206180-00012","volume":"136","author":"J.B. Smith","year":"2002","unstructured":"Smith JB, Haynes MK. Rheumatoid arthritis-A molecular understanding. Ann Intern Med 2002; 136:908\u2013922.","journal-title":"Ann Intern Med"},{"key":"11_CR2","first-page":"G769","volume":"273","author":"C. Fiocchi","year":"1997","unstructured":"Fiocchi C. Intestinal inflammation: A complex interplay of immune-non immune cell interactions. Am J Physiol 1997; 273:G769\u2013G775.","journal-title":"Am J Physiol"},{"key":"11_CR3","first-page":"G653","volume":"279","author":"J.B. Pucilowska","year":"2000","unstructured":"Pucilowska JB, Williams KL, Lund PK. Fibrogenesis. IV. Fibrosis and inflammatory bowel disease: Cellular mediators and animal models. Am J Physiol 2000; 279:G653\u2013G659.","journal-title":"Am J Physiol"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1097\/00001574-200107000-00004","volume":"17","author":"P.K. Lund","year":"2001","unstructured":"Lund PK, Zuniga CC. Intestinal fibrosis in human and experimental inflammatory bowel disease. Curr Opin Gastroenterol 2001; 17:318\u2013323.","journal-title":"Curr Opin Gastroenterol"},{"key":"11_CR5","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/BF00193944","volume":"425","author":"A. Schmitt-Graff","year":"1994","unstructured":"Schmitt-Graff A, Desmouliere A, Gabbiani G. Heterogeneity of myofibroblast phenotypic features: An example of fibroblast cell plasticity. Virchows Archiv 1994; 425:3\u201324.","journal-title":"Virchows Archiv"},{"key":"11_CR6","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/0016-5085(92)90087-F","volume":"102","author":"H. Matthes","year":"1992","unstructured":"Matthes H, Herbst H, Schuppan D et al. Cellular localization of procollagen gene transcripts in inflammatory bowel disease. Gastroenterology 1992; 102:431\u2013442.","journal-title":"Gastroenterology"},{"key":"11_CR7","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1053\/gast.1996.v110.pm8566579","volume":"110","author":"M.F. Graham","year":"1996","unstructured":"Graham MF, Willey A, Adams J et al. Interleukin 1\u03b2 down-regulates collagen and augments collagenase expression in human intestinal smooth muscle cells. Gastroenterology 1996; 110:344\u2013350.","journal-title":"Gastroenterology"},{"key":"11_CR8","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0167-5699(94)90006-X","volume":"15","author":"R. Hohlfeld","year":"1994","unstructured":"Hohlfeld R, Engel AG. The immunobiology of muscle. Immunol Today 1994; 15:269\u2013274.","journal-title":"Immunol Today"},{"key":"11_CR9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0016-5085(91)90456-U","volume":"101","author":"D.E. Vermillion","year":"1991","unstructured":"Vermillion DE, Ernst PB, Collins SM. T-lymphocyte modulation of intestinal muscle function in the Trichinella-infected rat. Gastroenterology 1991; 101:31\u201338.","journal-title":"Gastroenterology"},{"key":"11_CR10","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1053\/gast.1996.v110.pm8613051","volume":"110","author":"C.M. Hogaboam","year":"1996","unstructured":"Hogaboam CM, Snider DP, Collins SM. Activation of T lymphocytes by syngeneic murine intestinal smooth muscle cells. Gastroenterology 1996; 110:1456\u20131466.","journal-title":"Gastroenterology"},{"key":"11_CR11","doi-asserted-by":"crossref","first-page":"C1","DOI":"10.1152\/ajpcell.1999.277.1.C1","volume":"277","author":"D.W. Powell","year":"1999","unstructured":"Powell DW, Mifflin RC, Valentich JD et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am J Physiol 1999; 277:C1\u2013C19.","journal-title":"Am J Physiol"},{"key":"11_CR12","doi-asserted-by":"crossref","first-page":"C183","DOI":"10.1152\/ajpcell.1999.277.2.C183","volume":"277","author":"D.W. Powell","year":"1999","unstructured":"Powell DW, Mifflin RC, Valentich JD et al. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol 1999; 277:C183\u2013C210.","journal-title":"Am J Physiol"},{"key":"11_CR13","doi-asserted-by":"publisher","first-page":"2212","DOI":"10.1183\/09031936.94.07122212","volume":"7","author":"M. Jordana","year":"1994","unstructured":"Jordana M, Sarnstrand B, Sime PJ et al. Immune-inflammatory functions of fibroblasts. Eur Respir J 1994; 7:2212\u20132222.","journal-title":"Eur Respir J"},{"key":"11_CR14","first-page":"317","volume":"151","author":"R.S. Smith","year":"1997","unstructured":"Smith RS, Smith TJ, Blieden TM et al. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol 1997; 151:317\u2013322.","journal-title":"Am J Pathol"},{"key":"11_CR15","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/S0167-5699(97)01003-7","volume":"18","author":"A.N. Akbar","year":"1997","unstructured":"Akbar AN, Salmon M. Cellular environments and apoptosis: Tissue microenvironments control activated T-cell death. Immunol Today 1997; 18:72\u201376.","journal-title":"Immunol Today"},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"A841","DOI":"10.1016\/0016-5085(95)27672-6","volume":"108","author":"K. Ina","year":"1995","unstructured":"Ina K, Binion DG, West GA et al. Secretion of soluble factors and phagocytosis by intestinal fibroblasts regulate T-cell apoptosis. Gastroenterology 1995; 108:A841.","journal-title":"Gastroenterology"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","volume":"22","author":"C.D. Buckley","year":"2001","unstructured":"Buckley CD, Pilling D, Lord JM et al. Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation. Trends Immunol 2001; 22:199\u2013204.","journal-title":"Trends Immunol"},{"key":"11_CR18","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/j.1365-2249.1994.tb06048.x","volume":"96","author":"G. Pang","year":"1994","unstructured":"Pang G, Couch L, Batey R et al. GM-CSF, IL-1\u03b1, IL-1\u03b2, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated by lipolysaccharide, IL-1\u03b1 and TNF-\u03b1. Clin Exp Immunol 1994; 96:437\u2013443.","journal-title":"Clin Exp Immunol"},{"key":"11_CR19","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1016\/S0016-5085(98)70431-7","volume":"114","author":"S.A. Strong","year":"1998","unstructured":"Strong SA, Pizarro TT, Klein JS et al. Proinflammatory cytokines differentially modulate their own expression in human intestinal mucosal mesenchymal cells. Gastroenterology 1998; 114:1244\u20131256.","journal-title":"Gastroenterology"},{"key":"11_CR20","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/S0016-5085(99)70447-6","volume":"117","author":"A. Musso","year":"1999","unstructured":"Musso A, Condon TP, West GA et al. Regulation of ICAM-1-mediated fibroblast-T-cell reciprocal interaction: Implications for modulation of gut inflammation. Gastroenterology 1999; 117:546\u2013556.","journal-title":"Gastroenterology"},{"key":"11_CR21","doi-asserted-by":"crossref","first-page":"A192","DOI":"10.1016\/S0016-5085(01)80951-3","volume":"120","author":"J.D. Vogel","year":"2001","unstructured":"Vogel JD, West GA, Sturm A et al. Essential role of the CD40 pathway in T-cell-mediated induction of chemokines and cell adhesion molecules by human intestinal fibroblasts (HIF) and microvascular endothelial cells (HIMEC). Gastroenterology 2001; 120:A192.","journal-title":"Gastroenterology"},{"key":"11_CR22","doi-asserted-by":"crossref","first-page":"G1341","DOI":"10.1152\/ajpcell.1997.273.4.C1341","volume":"273","author":"Y.R. Mahida","year":"1997","unstructured":"Mahida YR, Beltinger J, Makh S et al. Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and-2. Am J Physiol 1997; 273:G1341\u2013G1348.","journal-title":"Am J Physiol"},{"key":"11_CR23","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.4049\/jimmunol.166.7.4465","volume":"166","author":"R.D. Newberry","year":"2001","unstructured":"Newberry RD, McDonough JS, Stenson WF et al. Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: Directing the tone of the intestinal immune response. J Immunol 2001; 166:4465\u20134472.","journal-title":"J Immunol"},{"key":"11_CR24","doi-asserted-by":"publisher","first-page":"A-111","DOI":"10.1053\/gast.2002.30982","volume":"122","author":"A.Z. Leite","year":"2002","unstructured":"Leite AZ, De la Motte C, Strong SA et al. Isolation and functional characterization of human intestinal mucosal stellate cells, Gastroenterology 2002; 122:A-111. (Abstract).","journal-title":"Gastroenterology"},{"key":"11_CR25","first-page":"G245","volume":"277","author":"E.A. Tol Van","year":"1999","unstructured":"Van Tol EA, Holt L, Li FL et al. Bacterial cell wall polymers promote intestinal fibrosis by direct stimulation of myofibroblasts. Am J Physiol 1999; 277:G245\u2013G255.","journal-title":"Am J Physiol"},{"key":"11_CR26","doi-asserted-by":"crossref","first-page":"A135","DOI":"10.1016\/S0016-5085(01)80664-8","volume":"120","author":"J.D. Vogel","year":"2001","unstructured":"Vogel JD, Majors A, Sturm A et al. Collagen synthesis by human intestinal fibroblasts (HIF) is modulated by T-cells through the CD40\/CD40 ligand (CD40L) pathway. Gastroenterology 2001; 120:A135.","journal-title":"Gastroenterology"},{"key":"11_CR27","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1097\/00007890-199010000-00001","volume":"50","author":"J.S. Pober","year":"1990","unstructured":"Pober JS, Cotran RS. The role of endothelial cells in inflammation. Transplantation 1990; 50:537\u2013544.","journal-title":"Transplantation"},{"key":"11_CR28","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S0065-2776(08)60022-X","volume":"72","author":"E.C. Butcher","year":"1999","unstructured":"Butcher EC, Williams M, Youngman K et al. Lymphocyte trafficking and regional immunity. Adv Immunol 1999; 72:209\u2013253.","journal-title":"Adv Immunol"},{"key":"11_CR29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1136\/gut.45.1.148","volume":"45","author":"M. Salmi","year":"1999","unstructured":"Salmi M, Jalkanen S. Molecules controlling lymphocyte migration to the gut. Gut 1999; 45:148\u2013153.","journal-title":"Gut"},{"key":"11_CR30","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1096\/fasebj.7.6.8472891","volume":"7","author":"M.E. Gerritsen","year":"1993","unstructured":"Gerritsen ME, Bloor CM. Endothelial cell gene expression in response to injury. FASEB J 1993; 7:523\u2013532.","journal-title":"FASEB J"},{"key":"11_CR31","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1016\/S0016-5085(98)70328-2","volume":"114","author":"J. Panes","year":"1998","unstructured":"Panes J, Granger DN. Leukocyte-endothelial interactions: Molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 1998; 114:1066\u20131090.","journal-title":"Gastroenterology"},{"key":"11_CR32","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1549-8719.2001.tb00177.x","volume":"8","author":"F.S. Laroux","year":"2001","unstructured":"Laroux FS, Grisham MB. Immunological basis of inflammatory bowel disease: Role of the microcirculation. Microcirculation 2001; 8:283\u2013301.","journal-title":"Microcirculation"},{"key":"11_CR33","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/0016-5085(92)90015-Q","volume":"103","author":"M. Koizumi","year":"1992","unstructured":"Koizumi M, King N, Lobb R et al. Expression of vascular adhesion molecules in inflammatory bowel disease. Gastroenterology 1992; 103:840\u2013847.","journal-title":"Gastroenterology"},{"key":"11_CR34","first-page":"77","volume":"69","author":"S. Nakamura","year":"1993","unstructured":"Nakamura S, Ohtani H, Watanabe Y et al. In situ expression of the cell adhesion molecules in inflammatory bowel disease. Lab Invest 1993; 69:77\u201385.","journal-title":"Lab Invest"},{"key":"11_CR35","first-page":"97","volume":"151","author":"M. Briskin","year":"1997","unstructured":"Briskin M, Winsor-Hines D, Shyjan A et al. Human mucosal addressin cell adhesion molecule-1 is preferentially expressed in intestinal tract and associated lymphoid tissue. Am J Pathol 1997; 151:97\u2013110.","journal-title":"Am J Pathol"},{"key":"11_CR36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1136\/gut.37.2.225","volume":"37","author":"G. Haraldsen","year":"1995","unstructured":"Haraldsen G, Rugveigt J, Kvale D et al. Isolation and longterm culture of human intestinal microvascular endothelial cells. Gut 1995; 37:225\u2013234.","journal-title":"Gut"},{"key":"11_CR37","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1136\/gut.42.5.635","volume":"42","author":"E.M. Nilsen","year":"1998","unstructured":"Nilsen EM, Johansen F-E, Jahnsen FL et al. Cytokine profiles of cultured microvascular endothelial cells from human intestine. Gut 1998; 42:635\u2013642.","journal-title":"Gut"},{"key":"11_CR38","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.4049\/jimmunol.156.7.2558","volume":"156","author":"G. Haraldsen","year":"1996","unstructured":"Haraldsen G, Kvale D, Lien B et al. Cytokine-regulated expression of E-selectin, intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) in human intestinal microvascular endothelial cells. J Immunol 1996; 156:2559\u20132565.","journal-title":"J Immunol"},{"key":"11_CR39","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1084\/jem.188.9.1751","volume":"188","author":"J.O. Utgaard","year":"1998","unstructured":"Utgaard JO, Jahnsen FL, Bakka A et al. Rapid secretion of prestored interleukin 8 from Weibel-Palade bodies of microvascular endothelial cells. J Exp Med 1998; 188:1751\u20131756.","journal-title":"J Exp Med"},{"key":"11_CR40","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/S0016-5085(98)70578-5","volume":"114","author":"G. Haraldsen","year":"1998","unstructured":"Haraldsen G, Sollid LM, Bakke O et al. Major histocompatibility complex call II-dependent antigen presentation by human intestinal endothelial cells. Gastroenterology 1998; 114:649\u2013656.","journal-title":"Gastroenterology"},{"key":"11_CR41","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1053\/gast.1997.v112.pm9178682","volume":"112","author":"D.G. Binion","year":"1997","unstructured":"Binion DG, West GA, Ina K et al. Enhanced leukocyte binding by intestinal microvascular endothelial cells in inflammatory bowel disease. Gastroenterology 1997; 112:1895\u20131907.","journal-title":"Gastroenterology"},{"key":"11_CR42","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1016\/S0140-6736(98)05050-8","volume":"352","author":"D.G. Binion","year":"1998","unstructured":"Binion DG, West GA, Volk EE et al. Acquired increase in leucocyte binding by intestinal microvascular endothelium in inflammatory bowel disease. Lancet 1998; 352:1742\u20131746.","journal-title":"Lancet"},{"key":"11_CR43","first-page":"G592","volume":"275","author":"D.G. Binion","year":"1998","unstructured":"Binion DG, Fu S, Ramanujam KR et al. iNOS expression in human intestinal microvascular endothelial cells inhibits leukocyte adhesion. Am J Physiol 1998; 275:G592\u2013G603.","journal-title":"Am J Physiol"},{"key":"11_CR44","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/S0891-5849(00)00391-9","volume":"29","author":"D.G. Binion","year":"2000","unstructured":"Binion DG, Rafiee P, Ramunujam KS et al. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radical Biol Med 2000; 29:881\u2013888.","journal-title":"Free Radical Biol Med"},{"key":"11_CR45","doi-asserted-by":"publisher","first-page":"35605","DOI":"10.1074\/jbc.M205826200","volume":"277","author":"P. Rafiee","year":"2002","unstructured":"Rafiee P, Johnson CP, Li MS et al. Cyclosporine A enhances leukocyte binding by human intestinal microvascular endothelial cells through inhibition of p38 MAPK and iNOS. J Biol Chem 2002; 277:35605\u201335615.","journal-title":"J Biol Chem"},{"key":"11_CR46","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/jlb.67.1.2","volume":"67","author":"C. Kooten van","year":"2000","unstructured":"van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol 2000; 67:2\u201317.","journal-title":"J Leukoc Biol"},{"key":"11_CR47","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1007\/PL00000776","volume":"58","author":"U. Schonbeck","year":"2001","unstructured":"Schonbeck U, Libby P. The CD40\/CD154 receptor\/ligand dyad. Cell Molec Life Sci 2001; 58:4\u201343.","journal-title":"Cell Molec Life Sci"},{"key":"11_CR48","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1038\/35393","volume":"391","author":"V. Henn","year":"1998","unstructured":"Henn V, Slupsky JR, Grafe M et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391:591\u2013594.","journal-title":"Nature"},{"key":"11_CR49","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.4049\/jimmunol.163.7.4049","volume":"163","author":"Z. Liu","year":"1999","unstructured":"Liu Z, Colpaert S, D\u2019Haens GR et al. Hyperexpression of CD40 ligand (CD154) in inflammatory bowel disease and its contribution to pathogenic cytokine production. J Immunol 1999; 163:4049\u20134057.","journal-title":"J Immunol"},{"key":"11_CR50","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1097\/00042737-200203000-00006","volume":"14","author":"L. Polese","year":"2002","unstructured":"Polese L, Angriman I, Cecchetto A et al. The role of CD40 in ulcerative colitis: Histochemical analysis and clinical correlation. Eur J Gastroenterol Hepatol 2002; 14:237\u2013241.","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"11_CR51","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1084\/jem.183.2.693","volume":"183","author":"E. Stuber","year":"1996","unstructured":"Stuber E, Strober W, Neurath M. Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of helper T helper 1 cells through the inhibition of interleukin 12 secretion. J Exp Med 1996; 183:693\u2013698.","journal-title":"J Exp Med"},{"key":"11_CR52","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1053\/gast.2000.16485","volume":"119","author":"Y. Jong de","year":"2000","unstructured":"de Jong Y, Comiskey M, Kalled SL et al. Chronic murine colitis is dependent on the CD154\/CD40 pathway and can be attenuated by anti-CD154 administration. Gastroenterology 2000; 119:715\u2013723.","journal-title":"Gastroenterology"},{"key":"11_CR53","first-page":"A-108","volume":"122","author":"S. Danese","year":"2002","unstructured":"Danese S, Katz J, Sturm A et al. Activated platelets in the circulation of inflammatory bowel disease (IBD) patients express CD40ligand and induce an inflammatory response in the intestinal microvasculature. Gastroenterology 2002; 122:A-108, (Abstract).","journal-title":"Gastroenterology"}],"container-title":["Advances in Experimental Medicine and Biology","Immune Mechanisms in Inflammatory Bowel Disease"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/0-387-33778-4_11","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T06:30:00Z","timestamp":1707633000000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/0-387-33778-4_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9780387308319","9780387337784"],"references-count":53,"URL":"https:\/\/doi.org\/10.1007\/0-387-33778-4_11","relation":{},"ISSN":["0065-2598"],"issn-type":[{"value":"0065-2598","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}