{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:00:20Z","timestamp":1782990020243,"version":"3.54.5"},"publisher-location":"Cham","reference-count":289,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031256271","type":"print"},{"value":"9783031256288","type":"electronic"}],"license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022]]},"DOI":"10.1007\/112_2022_73","type":"book-chapter","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T20:02:36Z","timestamp":1659384156000},"page":"135-176","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications"],"prefix":"10.1007","author":[{"given":"Bijayashree","family":"Sahu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ojas","family":"Tikoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benudhara","family":"Pati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Unmod","family":"Senapati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naresh C.","family":"Bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,8,2]]},"reference":[{"issue":"16","key":"73_CR1","doi-asserted-by":"publisher","first-page":"3076","DOI":"10.1128\/MCB.00185-14","volume":"34","author":"WN Addison","year":"2014","unstructured":"Addison WN, Fu MM, Yang HX, Lin Z, Nagano K, Gori F et al (2014) Direct transcriptional repression of Zfp423 by Zfp521 mediates a bone morphogenic protein-dependent osteoblast versus adipocyte lineage commitment switch. Mol Cell Biol 34(16):3076\u20133085","journal-title":"Mol Cell Biol"},{"issue":"5","key":"73_CR2","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1038\/nm.3159","volume":"19","author":"M Ahmadian","year":"2013","unstructured":"Ahmadian M, Suh JM, Hah N, Liddle C, Atkins AR, Downes M et al (2013) PPARgamma signaling and metabolism: the good, the bad and the future. Nat Med 19(5):557\u2013566","journal-title":"Nat Med"},{"key":"73_CR3","unstructured":"Akinci B, Sahinoz M, Oral E (2018) Lipodystrophy syndromes: presentation and treatment"},{"issue":"5","key":"73_CR4","doi-asserted-by":"publisher","first-page":"E918","DOI":"10.1152\/ajpendo.00798.2007","volume":"294","author":"DL Allen","year":"2008","unstructured":"Allen DL, Cleary AS, Speaker KJ, Lindsay SF, Uyenishi J, Reed JM et al (2008) Myostatin, activin receptor IIb, and follistatin-like-3 gene expression are altered in adipose tissue and skeletal muscle of obese mice. Am J Physiol Endocrinol Metab 294(5):E918\u2013EE27","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"16","key":"73_CR5","doi-asserted-by":"publisher","first-page":"e14540","DOI":"10.14814\/phy2.14540","volume":"8","author":"Y Amano","year":"2020","unstructured":"Amano Y, Nonaka Y, Takeda R, Kano Y, Hoshino D (2020) Effects of electrical stimulation-induced resistance exercise training on white and brown adipose tissues and plasma meteorin-like concentration in rats. Physiol Rep 8(16):e14540","journal-title":"Physiol Rep"},{"issue":"12","key":"73_CR6","doi-asserted-by":"publisher","first-page":"4283","DOI":"10.3390\/ijms21124283","volume":"21","author":"MA Ambele","year":"2020","unstructured":"Ambele MA, Dhanraj P, Giles R, Pepper MS (2020) Adipogenesis: a complex interplay of multiple molecular determinants and pathways. Int J Mol Sci 21(12):4283","journal-title":"Int J Mol Sci"},{"key":"73_CR7","first-page":"2877","volume":"8","author":"F Arroyave","year":"2020","unstructured":"Arroyave F, Monta\u00f1o D, Lizcano F (2020) Adipose tissue browning for the treatment of obesity and metabolic diseases. CellR4 8:2877","journal-title":"CellR4"},{"key":"73_CR8","doi-asserted-by":"publisher","first-page":"6283932","DOI":"10.1155\/2018\/6283932","volume":"2018","author":"JY Bae","year":"2018","unstructured":"Bae JY (2018) Aerobic exercise increases meteorin-like protein in muscle and adipose tissue of chronic high-fat diet-induced obese mice. Biomed Res Int 2018:6283932","journal-title":"Biomed Res Int"},{"key":"73_CR9","doi-asserted-by":"crossref","unstructured":"Bal NC, Maurya SK, Pani S, Sethy C, Banerjee A, Das S et al (2017a) Mild cold induced thermogenesis: are BAT and skeletal muscle synergistic partners? Biosci Rep 37(5)","DOI":"10.1042\/BSR20171087"},{"issue":"40","key":"73_CR10","doi-asserted-by":"publisher","first-page":"16616","DOI":"10.1074\/jbc.M117.790451","volume":"292","author":"NC Bal","year":"2017","unstructured":"Bal NC, Singh S, Reis FCG, Maurya SK, Pani S, Rowland LA et al (2017b) Both brown adipose tissue and skeletal muscle thermogenesis processes are activated during mild to severe cold adaptation in mice. J Biol Chem 292(40):16616\u201316625","journal-title":"J Biol Chem"},{"issue":"6","key":"73_CR11","doi-asserted-by":"publisher","first-page":"E1244","DOI":"10.1152\/ajpendo.00600.2009","volume":"298","author":"G Barbatelli","year":"2010","unstructured":"Barbatelli G, Murano I, Madsen L, Hao Q, Jimenez M, Kristiansen K et al (2010) The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation. Am J Physiol Endocrinol Metab 298(6):E1244\u2013E1E53","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"73_CR12","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S0167-5273(98)00129-6","volume":"65","author":"G Barletta","year":"1998","unstructured":"Barletta G, Stefani L, Del Bene R, Fronzaroli C, Vecchiarino S, Lazzeri C et al (1998) Effects of exercise on natriuretic peptides and cardiac function in man. Int J Cardiol 65(3):217\u2013225","journal-title":"Int J Cardiol"},{"issue":"2","key":"73_CR13","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/nm.2297","volume":"17","author":"A Bartelt","year":"2011","unstructured":"Bartelt A, Bruns OT, Reimer R, Hohenberg H, Ittrich H, Peldschus K et al (2011) Brown adipose tissue activity controls triglyceride clearance. Nat Med 17(2):200\u2013205","journal-title":"Nat Med"},{"issue":"1","key":"73_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms7356","volume":"6","author":"JF Berb\u00e9e","year":"2015","unstructured":"Berb\u00e9e JF, Boon MR, Khedoe PPS, Bartelt A, Schlein C, Worthmann A et al (2015) Brown fat activation reduces hypercholesterolaemia and protects from atherosclerosis development. Nat Commun 6(1):1\u201311","journal-title":"Nat Commun"},{"issue":"7","key":"73_CR15","doi-asserted-by":"publisher","first-page":"4845","DOI":"10.1074\/jbc.M106574200","volume":"277","author":"V B\u00e9r\u00e9ziat","year":"2002","unstructured":"B\u00e9r\u00e9ziat V, Kasus-Jacobi A, Perdereau D, Cariou B, Girard J, Burnol A-F (2002) Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14. J Biol Chem 277(7):4845\u20134852","journal-title":"J Biol Chem"},{"issue":"6","key":"73_CR16","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1016\/0361-9230(85)90103-0","volume":"14","author":"LL Bernardis","year":"1985","unstructured":"Bernardis LL (1985) Ventromedial and dorsomedial hypothalamic syndromes in the weanling rat: is the \u201ccenter\u201d concept really outmoded? Brain Res Bull 14(6):537\u2013549","journal-title":"Brain Res Bull"},{"issue":"4","key":"73_CR17","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.cmet.2017.03.002","volume":"25","author":"AM Bertholet","year":"2017","unstructured":"Bertholet AM, Kazak L, Chouchani ET, Bogaczy\u0144ska MG, Paranjpe I, Wainwright GL et al (2017) Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling. Cell Metab 25(4):811\u201322.e4","journal-title":"Cell Metab"},{"issue":"1","key":"73_CR18","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/nyas.12258","volume":"1302","author":"S Bi","year":"2013","unstructured":"Bi S, Li L (2013) Browning of white adipose tissue: role of hypothalamic signaling. Ann N Y Acad Sci 1302(1):30\u201334","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"73_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s12015-011-9242-x","volume":"8","author":"N Billon","year":"2012","unstructured":"Billon N, Dani C (2012) Developmental origins of the adipocyte lineage: new insights from genetics and genomics studies. Stem Cell Rev Rep 8(1):55\u201366","journal-title":"Stem Cell Rev Rep"},{"issue":"8","key":"73_CR20","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1007\/s00125-002-0875-9","volume":"45","author":"M Bj\u00f6rnholm","year":"2002","unstructured":"Bj\u00f6rnholm M, Al-Khalili L, Dicker A, N\u00e4slund E, R\u00f6ssner S, Zierath J et al (2002) Insulin signal transduction and glucose transport in human adipocytes: effects of obesity and low calorie diet. Diabetologia 45(8):1128\u20131135","journal-title":"Diabetologia"},{"issue":"5","key":"73_CR21","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/1753-0407.12645","volume":"10","author":"Z Bloomgarden","year":"2018","unstructured":"Bloomgarden Z (2018) Diabetes and branched-chain amino acids: what is the link? J Diabetes 10(5):350\u2013352","journal-title":"J Diabetes"},{"issue":"1","key":"73_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.yhbeh.2014.02.007","volume":"66","author":"ID Bloor","year":"2014","unstructured":"Bloor ID, Symonds ME (2014) Sexual dimorphism in white and brown adipose tissue with obesity and inflammation. Horm Behav 66(1):95\u2013103","journal-title":"Horm Behav"},{"issue":"4","key":"73_CR23","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1097\/00005768-199904000-00008","volume":"31","author":"PF Bodary","year":"1999","unstructured":"Bodary PF, Pate RR, Wu QF, Mcmillan GS (1999) Effects of acute exercise on plasma erythropoietin levels in trained runners. Med Sci Sports Exerc 31(4):543\u2013546","journal-title":"Med Sci Sports Exerc"},{"issue":"9","key":"73_CR24","doi-asserted-by":"publisher","first-page":"3871","DOI":"10.1096\/fj.13-230631","volume":"27","author":"E Bombardier","year":"2013","unstructured":"Bombardier E, Smith IC, Gamu D, Fajardo VA, Vigna C, Sayer RA et al (2013) Sarcolipin trumps beta-adrenergic receptor signaling as the favored mechanism for muscle-based diet-induced thermogenesis. FASEB J 27(9):3871\u20133878","journal-title":"FASEB J"},{"key":"73_CR25","series-title":"Turning up the heat: role of brown adipose tissue","first-page":"53","volume-title":"Brown adipose tissue internalizes fatty acids by selective delipidation of lipoproteins rather than by uptake of lipoproteins","author":"MR Boon","year":"2014","unstructured":"Boon MR, Khedoe PPS, Hoeke G, Kooijman S, Dijk W, Kersten S et al (2014) Brown adipose tissue internalizes fatty acids by selective delipidation of lipoproteins rather than by uptake of lipoproteins, Turning up the heat: role of brown adipose tissue, p 53"},{"issue":"5","key":"73_CR26","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1097\/MED.0b013e32832fa137","volume":"16","author":"M Bose","year":"2009","unstructured":"Bose M, Oliv\u00e1n B, Laferr\u00e8re B (2009) Stress and obesity: the role of the hypothalamic-pituitary-adrenal axis in metabolic disease. Curr Opin Endocrinol Diabetes Obes 16(5):340\u2013346","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"7382","key":"73_CR27","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nature10777","volume":"481","author":"P Bostr\u00f6m","year":"2012","unstructured":"Bostr\u00f6m P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC et al (2012) A PGC1-\u03b1-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature 481(7382):463\u2013468","journal-title":"Nature"},{"issue":"8","key":"73_CR28","doi-asserted-by":"publisher","first-page":"2201","DOI":"10.2337\/db16-0212","volume":"65","author":"J Boucher","year":"2016","unstructured":"Boucher J, Softic S, El Ouaamari A, Krumpoch MT, Kleinridders A, Kulkarni RN et al (2016) Differential roles of insulin and IGF-1 receptors in adipose tissue development and function. Diabetes 65(8):2201\u20132213","journal-title":"Diabetes"},{"issue":"4","key":"73_CR29","doi-asserted-by":"publisher","first-page":"E581","DOI":"10.1152\/ajpendo.90437.2008","volume":"296","author":"S Boura-Halfon","year":"2009","unstructured":"Boura-Halfon S, Zick Y (2009) Phosphorylation of IRS proteins, insulin action, and insulin resistance. Am J Physiol Endocrinol Metab 296(4):E581\u2013EE91","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"73_CR30","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1194\/jlr.M039719","volume":"55","author":"M Braga","year":"2014","unstructured":"Braga M, Reddy ST, Vergnes L, Pervin S, Grijalva V, Stout D et al (2014) Follistatin promotes adipocyte differentiation, browning, and energy metabolism. J Lipid Res 55(3):375\u2013384","journal-title":"J Lipid Res"},{"issue":"7542","key":"73_CR31","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/nature14115","volume":"519","author":"JR Brestoff","year":"2015","unstructured":"Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF et al (2015) Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature 519(7542):242\u2013246","journal-title":"Nature"},{"issue":"1","key":"73_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/nyas.14257","volume":"1463","author":"AC Brown","year":"2020","unstructured":"Brown AC (2020) Brown adipocytes from induced pluripotent stem cells-how far have we come? Ann N Y Acad Sci 1463(1):9\u201322","journal-title":"Ann N Y Acad Sci"},{"issue":"8","key":"73_CR33","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.2337\/diabetes.50.8.1883","volume":"50","author":"\u00c0 Cabrero","year":"2001","unstructured":"Cabrero \u00c0, Alegret M, S\u00e1nchez RM, Adzet T, Laguna JC, V\u00e1zquez M (2001) Bezafibrate reduces mRNA levels of adipocyte markers and increases fatty acid oxidation in primary culture of adipocytes. Diabetes 50(8):1883\u20131890","journal-title":"Diabetes"},{"issue":"23","key":"73_CR34","doi-asserted-by":"publisher","first-page":"e2104650118","DOI":"10.1073\/pnas.2104650118","volume":"118","author":"J Cannavino","year":"2021","unstructured":"Cannavino J, Shao M, An YA, Bezprozvannaya S, Chen S, Kim J et al (2021) Regulation of cold-induced thermogenesis by the RNA binding protein FAM195A. Proc Natl Acad Sci 118(23):e2104650118","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"73_CR35","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1152\/physrev.00015.2003","volume":"84","author":"B Cannon","year":"2004","unstructured":"Cannon B, Nedergaard J (2004) Brown adipose tissue: function and physiological significance. Physiol Rev 84(1):277\u2013359","journal-title":"Physiol Rev"},{"key":"73_CR36","doi-asserted-by":"crossref","unstructured":"Caputo T, Tran V, Bararpour N, Winkler C, Aguileta G, Trang K et al (2021) Anti-adipogenic signals at the onset of obesity-related inflammation in white adipose tissue. Cell Mol Life Sci 78","DOI":"10.1007\/s00018-020-03485-z"},{"issue":"1","key":"73_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0304-4165(00)00188-4","volume":"1526","author":"N Carb\u00f3","year":"2001","unstructured":"Carb\u00f3 N, L\u00f3pez-Soriano JN, Costelli P, Alvarez B, Busquets SL, Baccino FM et al (2001) Interleukin-15 mediates reciprocal regulation of adipose and muscle mass: a potential role in body weight control. Biochim Biophys Acta 1526(1):17\u201324","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"73_CR38","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.2337\/db05-1404","volume":"55","author":"AL Carey","year":"2006","unstructured":"Carey AL, Steinberg GR, Macaulay SL, Thomas WG, Holmes AG, Ramm G et al (2006) Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes 55(10):2688\u20132697","journal-title":"Diabetes"},{"key":"73_CR39","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3389\/fendo.2018.00447","volume":"9","author":"AC Carpentier","year":"2018","unstructured":"Carpentier AC, Blondin DP, Virtanen KA, Richard D, Haman F, Turcotte \u00c9E (2018) Brown adipose tissue energy metabolism in humans. Front Endocrinol 9:447","journal-title":"Front Endocrinol"},{"issue":"9","key":"73_CR40","doi-asserted-by":"publisher","first-page":"e47903","DOI":"10.15252\/embr.201947903","volume":"20","author":"J Castillo-Armengol","year":"2019","unstructured":"Castillo-Armengol J, Fajas L, Lopez-Mejia IC (2019) Inter-organ communication: a gatekeeper for metabolic health. EMBO Rep 20(9):e47903","journal-title":"EMBO Rep"},{"issue":"1","key":"73_CR41","doi-asserted-by":"publisher","first-page":"19","DOI":"10.15386\/cjm.2014.8872.871.afc1","volume":"87","author":"AF C\u0103toi","year":"2014","unstructured":"C\u0103toi AF, Suciu \u015e, P\u00c2rvu AE, Cop\u0103escu C, Galea RF, Buzoianu AD et al (2014) Increased chemerin and decreased omentin-1 levels in morbidly obese patients are correlated with insulin resistance, oxidative stress and chronic inflammation. Clujul Med 87(1):19","journal-title":"Clujul Med"},{"issue":"7","key":"73_CR42","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1038\/sj.cdd.4402127","volume":"14","author":"W Cawthorn","year":"2007","unstructured":"Cawthorn W, Heyd F, Hegyi K, Sethi J (2007) Tumour necrosis factor-\u03b1 inhibits adipogenesis via a \u03b2-catenin\/TCF4 (TCF7L2)-dependent pathway. Cell Death Differ 14(7):1361\u20131373","journal-title":"Cell Death Differ"},{"issue":"5","key":"73_CR43","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/S0092-8674(01)00474-3","volume":"106","author":"A Cederberg","year":"2001","unstructured":"Cederberg A, Gr\u00f8nning LM, Ahr\u00e9n B, Task\u00e9n K, Carlsson P, Enerb\u00e4ck S (2001) FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106(5):563\u2013573. https:\/\/doi.org\/10.1016\/S0092-8674(01)00474-3","journal-title":"Cell"},{"key":"73_CR44","doi-asserted-by":"crossref","unstructured":"Chait A, den Hartigh LJ (2020) Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease. Front Cardiovasc Med 7(22)","DOI":"10.3389\/fcvm.2020.00022"},{"issue":"1","key":"73_CR45","doi-asserted-by":"publisher","first-page":"8833","DOI":"10.1038\/s41598-019-45354-1","volume":"9","author":"JC Chang","year":"2019","unstructured":"Chang JC, Durinck S, Chen MZ, Martinez-Martin N, Zhang JA, Lehoux I et al (2019) Adaptive adipose tissue stromal plasticity in response to cold stress and antibody-based metabolic therapy. Sci Rep 9(1):8833","journal-title":"Sci Rep"},{"issue":"4","key":"73_CR46","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1159\/000455865","volume":"104","author":"W Chen","year":"2017","unstructured":"Chen W, Balland E, Cowley MA (2017) Hypothalamic insulin resistance in obesity: effects on glucose homeostasis. Neuroendocrinology 104(4):364\u2013381","journal-title":"Neuroendocrinology"},{"issue":"1","key":"73_CR47","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1007\/s11154-015-9310-7","volume":"16","author":"R Cheng","year":"2015","unstructured":"Cheng R, Ma J-x (2015) Angiogenesis in diabetes and obesity. Rev Endocr Metab Disord 16(1):67\u201375","journal-title":"Rev Endocr Metab Disord"},{"issue":"1","key":"73_CR48","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1210\/en.2003-0857","volume":"145","author":"E Chernogubova","year":"2004","unstructured":"Chernogubova E, Cannon B, Bengtsson T (2004) Norepinephrine increases glucose transport in brown adipocytes via \u03b23-adrenoceptors through a cAMP, PKA, and PI3-kinase-dependent pathway stimulating conventional and novel PKCs. Endocrinology 145(1):269\u2013280","journal-title":"Endocrinology"},{"issue":"4","key":"73_CR49","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1161\/01.RES.0000259564.92792.93","volume":"100","author":"C-H Cho","year":"2007","unstructured":"Cho C-H, Jun Koh Y, Han J, Sung H-K, Jong Lee H, Morisada T et al (2007) Angiogenic role of LYVE-1\u2013positive macrophages in adipose tissue. Circ Res 100(4):e47\u2013e57","journal-title":"Circ Res"},{"key":"73_CR50","doi-asserted-by":"crossref","unstructured":"Choe SS, Huh JY, Hwang IJ, Kim JI, Kim JB (2016) Adipose tissue remodeling: its role in energy metabolism and metabolic disorders. Front Endocrinol 7(30)","DOI":"10.3389\/fendo.2016.00030"},{"key":"73_CR51","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.metabol.2018.09.005","volume":"92","author":"YC Chooi","year":"2019","unstructured":"Chooi YC, Ding C, Magkos F (2019) The epidemiology of obesity. Metabolism 92:6\u201310. https:\/\/doi.org\/10.1016\/j.metabol.2018.09.005","journal-title":"Metabolism"},{"issue":"1","key":"73_CR52","doi-asserted-by":"publisher","first-page":"50","DOI":"10.4161\/adip.29853","volume":"4","author":"M Christian","year":"2015","unstructured":"Christian M (2015) Transcriptional fingerprinting of \u201cbrowning\u201d white fat identifies NRG4 as a novel adipokine. Adipocytes 4(1):50\u201354","journal-title":"Adipocytes"},{"key":"73_CR53","series-title":"Rare diseases","volume-title":"Lipodystrophy \u2013 a rare condition with serious metabolic abnormalities","author":"LH Chung","year":"2019","unstructured":"Chung LH, Qi Y (2019) Lipodystrophy \u2013 a rare condition with serious metabolic abnormalities, Rare diseases. IntechOpen"},{"key":"73_CR54","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnut.2016.00010","volume":"3","author":"DE Chusyd","year":"2016","unstructured":"Chusyd DE, Wang D, Huffman DM, Nagy TR (2016) Relationships between rodent white adipose fat pads and human white adipose fat depots. Front Nutr 3:10","journal-title":"Front Nutr"},{"issue":"3","key":"73_CR55","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1080\/21623945.2017.1372871","volume":"6","author":"L Cleal","year":"2017","unstructured":"Cleal L, Aldea T, Chau Y-Y (2017) Fifty shades of white: understanding heterogeneity in white adipose stem cells. Adipocyte 6(3):205\u2013216. https:\/\/doi.org\/10.1080\/21623945.2017.1372871","journal-title":"Adipocyte"},{"issue":"9","key":"73_CR56","doi-asserted-by":"publisher","first-page":"E793","DOI":"10.1152\/ajpendo.00033.2014","volume":"307","author":"GA Contreras","year":"2014","unstructured":"Contreras GA, Lee Y-H, Mottillo EP, Granneman JG (2014) Inducible brown adipocytes in subcutaneous inguinal white fat: the role of continuous sympathetic stimulation. Am J Physiol Endocrinol Metab 307(9):E793\u2013E7E9","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"73_CR57","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/j.bbadis.2013.06.003","volume":"1842","author":"S Corvera","year":"2014","unstructured":"Corvera S, Gealekman O (2014) Adipose tissue angiogenesis: impact on obesity and type-2 diabetes. Biochim Biophys Acta 1842(3):463\u2013472","journal-title":"Biochim Biophys Acta"},{"issue":"12","key":"73_CR58","doi-asserted-by":"publisher","first-page":"6018","DOI":"10.1210\/en.2008-0816","volume":"149","author":"T Coskun","year":"2008","unstructured":"Coskun T, Bina HA, Schneider MA, Dunbar JD, Hu CC, Chen Y et al (2008) Fibroblast growth factor 21 corrects obesity in mice. Endocrinology 149(12):6018\u20136027","journal-title":"Endocrinology"},{"issue":"Suppl 2","key":"73_CR59","doi-asserted-by":"publisher","first-page":"34S","DOI":"10.2967\/jnumed.120.246991","volume":"62","author":"JP Crandall","year":"2021","unstructured":"Crandall JP, Wahl RL (2021) Perspectives on Brown adipose tissue imaging: insights from preclinical and clinical observations from the last and current century. J Nucl Med 62(Suppl 2):34S\u201343S","journal-title":"J Nucl Med"},{"issue":"39","key":"73_CR60","doi-asserted-by":"publisher","first-page":"16271","DOI":"10.1073\/pnas.1109409108","volume":"108","author":"AG Cristancho","year":"2011","unstructured":"Cristancho AG, Schupp M, Lefterova MI, Cao S, Cohen DM, Chen CS et al (2011) Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells. Proc Natl Acad Sci 108(39):16271\u201316276","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"73_CR61","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1002\/ajhb.22493","volume":"26","author":"AB Crujeiras","year":"2014","unstructured":"Crujeiras AB, Pardo M, Arturo RR, Santiago NC, Zulet MA, Mart\u00ednez JA et al (2014) Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women. Am J Hum Biol 26(2):198\u2013207","journal-title":"Am J Hum Biol"},{"issue":"12","key":"73_CR62","doi-asserted-by":"publisher","first-page":"9047","DOI":"10.1074\/jbc.275.12.9047","volume":"275","author":"R Davis","year":"2000","unstructured":"Davis R, Aguirre V, Uchida T, Yenush L, White MF (2000) The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J Biol Chem 275(12):9047\u20139054","journal-title":"J Biol Chem"},{"issue":"07","key":"73_CR63","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1055\/s-0029-1202852","volume":"41","author":"J Davis","year":"2009","unstructured":"Davis J, Gabler N, Walker-Daniels J, Spurlock M (2009) The c-Jun N-terminal kinase mediates the induction of oxidative stress and insulin resistance by palmitate and toll-like receptor 2 and 4 ligands in 3T3-L1 adipocytes. Horm Metab Res 41(07):523\u2013530","journal-title":"Horm Metab Res"},{"key":"73_CR64","doi-asserted-by":"publisher","unstructured":"De Jong J, Larsson O, Cannon B, Nedergaard J (2015) A stringent validation of mouse adipose tissue identity markers. Am J Physiol Endocrinol Metab 308. https:\/\/doi.org\/10.1152\/ajpendo.00023.2015","DOI":"10.1152\/ajpendo.00023.2015"},{"issue":"1","key":"73_CR65","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1089\/met.2017.0128","volume":"16","author":"R de Mutsert","year":"2018","unstructured":"de Mutsert R, Gast K, Widya R, de Koning E, Jazet I, Lamb H et al (2018) Associations of abdominal subcutaneous and visceral fat with insulin resistance and secretion differ between men and women: the Netherlands epidemiology of obesity study. Metab Syndr Relat Disord 16(1):54\u201363","journal-title":"Metab Syndr Relat Disord"},{"issue":"12","key":"73_CR66","doi-asserted-by":"publisher","first-page":"2984","DOI":"10.1038\/oby.2007.356","volume":"15","author":"EW Demerath","year":"2007","unstructured":"Demerath EW, Sun SS, Rogers N, Lee M, Reed D, Choh AC et al (2007) Anatomical patterning of visceral adipose tissue: race, sex, and age variation. Obesity 15(12):2984\u20132993","journal-title":"Obesity"},{"issue":"12","key":"73_CR67","doi-asserted-by":"publisher","first-page":"2458","DOI":"10.1038\/s41366-019-0421-1","volume":"43","author":"NF Denton","year":"2019","unstructured":"Denton NF, Eghleilib M, Al-Sharifi S, Todor\u010devi\u0107 M, Neville MJ, Loh N et al (2019) Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis. Int J Obes (Lond) 43(12):2458\u20132468","journal-title":"Int J Obes (Lond)"},{"issue":"8","key":"73_CR68","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1161\/01.ATV.20.8.1932","volume":"20","author":"J-P Despr\u00e9s","year":"2000","unstructured":"Despr\u00e9s J-P, Couillard C, Gagnon J, Bergeron J, Leon AS, Rao D et al (2000) Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the health, risk factors, exercise training, and genetics (HERITAGE) family study. Arterioscler Thromb Vasc Biol 20(8):1932\u20131938","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"73_CR69","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.bbalip.2018.04.013","volume":"1864","author":"RS Dewal","year":"2019","unstructured":"Dewal RS, Stanford KI (2019) Effects of exercise on brown and beige adipocytes. Biochim Biophys Acta 1864(1):71\u201378","journal-title":"Biochim Biophys Acta"},{"issue":"10","key":"73_CR70","doi-asserted-by":"publisher","first-page":"E1903","DOI":"10.1210\/jc.2014-1431","volume":"99","author":"A Di Franco","year":"2014","unstructured":"Di Franco A, Guasti D, Mazzanti B, Ercolino T, Francalanci M, Nesi G et al (2014) Dissecting the origin of inducible brown fat in adult humans through a novel adipose stem cell model from adipose tissue surrounding pheochromocytoma. J Clin Endocrinol Metabol 99(10):E1903\u2013E1E12","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"73_CR71","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1530\/JOE-16-0229","volume":"231","author":"X Ding","year":"2016","unstructured":"Ding X, Luo Y, Zhang X, Zheng H, Yang X, Yang X et al (2016) IL-33-driven ILC2\/eosinophil axis in fat is induced by sympathetic tone and suppressed by obesity. J Endocrinol 231(1):35","journal-title":"J Endocrinol"},{"issue":"1","key":"73_CR72","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.cell.2014.12.022","volume":"160","author":"GT Dodd","year":"2015","unstructured":"Dodd GT, Decherf S, Loh K, Simonds Stephanie E, Wiede F, Balland E et al (2015) Leptin and insulin act on POMC neurons to promote the browning of white fat. Cell 160(1):88\u2013104","journal-title":"Cell"},{"issue":"3","key":"73_CR73","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1080\/10408363.2019.1699498","volume":"57","author":"S Emamgholipour","year":"2020","unstructured":"Emamgholipour S, Ebrahimi R, Bahiraee A, Niazpour F, Meshkani R (2020) Acetylation and insulin resistance: a focus on metabolic and mitogenic cascades of insulin signaling. Crit Rev Clin Lab Sci 57(3):196\u2013214","journal-title":"Crit Rev Clin Lab Sci"},{"key":"73_CR74","doi-asserted-by":"crossref","unstructured":"Errico J (2018) Insulin resistance, glucose metabolism, inflammation, and the role of neuromodulation as a therapy for type-2 diabetes. Neuromodulation:1565\u20131573","DOI":"10.1016\/B978-0-12-805353-9.00133-9"},{"issue":"9","key":"73_CR75","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1016\/j.cmet.2021.07.015","volume":"33","author":"Z Fan","year":"2021","unstructured":"Fan Z, Turiel G, Ardicoglu R, Ghobrial M, Masschelein E, Kocijan T et al (2021) Exercise-induced angiogenesis is dependent on metabolically primed ATF3\/4+ endothelial cells. Cell Metab 33(9):1793\u2013807.e9","journal-title":"Cell Metab"},{"issue":"7","key":"73_CR76","doi-asserted-by":"publisher","first-page":"9755","DOI":"10.1096\/fj.201902518R","volume":"34","author":"W Fang","year":"2020","unstructured":"Fang W, Deng Z, Benadjaoud F, Yang D, Yang C, Shi G-P (2020) Regulatory T cells promote adipocyte beiging in subcutaneous adipose tissue. FASEB J 34(7):9755\u20139770","journal-title":"FASEB J"},{"issue":"2","key":"73_CR77","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.cell.2012.09.010","volume":"151","author":"A Fedorenko","year":"2012","unstructured":"Fedorenko A, Lishko PV, Kirichok Y (2012) Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria. Cell 151(2):400\u2013413","journal-title":"Cell"},{"issue":"20","key":"73_CR78","doi-asserted-by":"publisher","first-page":"7711","DOI":"10.3390\/ijms21207711","volume":"21","author":"S Feij\u00f3o-Band\u00edn","year":"2020","unstructured":"Feij\u00f3o-Band\u00edn S, Arag\u00f3n-Herrera A, Mora\u00f1a-Fern\u00e1ndez S, Anido-Varela L, Taraz\u00f3n E, Rosell\u00f3-Llet\u00ed E et al (2020) Adipokines and inflammation: focus on cardiovascular diseases. Int J Mol Sci 21(20):7711","journal-title":"Int J Mol Sci"},{"issue":"2","key":"73_CR79","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1210\/er.2013-1087","volume":"35","author":"C Fekete","year":"2014","unstructured":"Fekete C, Lechan RM (2014) Central regulation of hypothalamic-pituitary-thyroid axis under physiological and pathophysiological conditions. Endocr Rev 35(2):159\u2013194","journal-title":"Endocr Rev"},{"key":"73_CR80","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.mam.2019.07.003","volume":"68","author":"R Fern\u00e1ndez-Verdejo","year":"2019","unstructured":"Fern\u00e1ndez-Verdejo R, Marlatt KL, Ravussin E, Galgani JE (2019) Contribution of brown adipose tissue to human energy metabolism. Mol Aspects Med 68:82\u201389","journal-title":"Mol Aspects Med"},{"issue":"3","key":"73_CR81","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nrendo.2010.199","volume":"7","author":"CG Fiorenza","year":"2011","unstructured":"Fiorenza CG, Chou SH, Mantzoros CS (2011) Lipodystrophy: pathophysiology and advances in treatment. Nat Rev Endocrinol 7(3):137\u2013150","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"73_CR82","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.2337\/diabetes.54.5.1331","volume":"54","author":"M Foretz","year":"2005","unstructured":"Foretz M, Ancellin N, Andreelli F, Saintillan Y, Grondin P, Kahn A et al (2005) Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54(5):1331\u20131339","journal-title":"Diabetes"},{"issue":"4","key":"73_CR83","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1172\/JCI113744","volume":"82","author":"G Freidenberg","year":"1988","unstructured":"Freidenberg G, Reichart D, Olefsky J, Henry R (1988) Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss. J Clin Invest 82(4):1398\u20131406","journal-title":"J Clin Invest"},{"issue":"4","key":"73_CR84","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1159\/000448180","volume":"43","author":"L Frese","year":"2016","unstructured":"Frese L, Dijkman PE, Hoerstrup SP (2016) Adipose tissue-derived stem cells in regenerative medicine. Transfus Med Hemother 43(4):268\u2013274","journal-title":"Transfus Med Hemother"},{"key":"73_CR85","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.molmet.2017.12.010","volume":"8","author":"T Fromme","year":"2018","unstructured":"Fromme T, Kleigrewe K, Dunkel A, Retzler A, Li Y, Maurer S et al (2018) Degradation of brown adipocyte purine nucleotides regulates uncoupling protein 1 activity. Molecular Metabolism 8:77\u201385","journal-title":"Molecular Metabolism"},{"issue":"1","key":"73_CR86","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1017\/S095442241400002X","volume":"27","author":"G Fr\u00fchbeck","year":"2014","unstructured":"Fr\u00fchbeck G, M\u00e9ndez-Gim\u00e9nez L, Fern\u00e1ndez-Formoso J-A, Fern\u00e1ndez S, Rodriguez A (2014) Regulation of adipocyte lipolysis. Nutr Res Rev 27(1):63\u201393","journal-title":"Nutr Res Rev"},{"issue":"11","key":"73_CR87","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1161\/CIRCRESAHA.115.306885","volume":"118","author":"JJ Fuster","year":"2016","unstructured":"Fuster JJ, Ouchi N, Gokce N, Walsh K (2016) Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease. Circ Res 118(11):1786\u20131807","journal-title":"Circ Res"},{"issue":"50","key":"73_CR88","doi-asserted-by":"publisher","first-page":"48115","DOI":"10.1074\/jbc.M209459200","volume":"277","author":"Z Gao","year":"2002","unstructured":"Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ et al (2002) Serine phosphorylation of insulin receptor substrate 1 by inhibitor \u03baB kinase complex. J Biol Chem 277(50):48115\u201348121","journal-title":"J Biol Chem"},{"issue":"1","key":"73_CR89","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12986-016-0081-2","volume":"13","author":"RA Garcia","year":"2016","unstructured":"Garcia RA, Roemmich JN, Claycombe KJ (2016) Evaluation of markers of beige adipocytes in white adipose tissue of the mouse. Nutr Metab 13(1):24","journal-title":"Nutr Metab"},{"key":"73_CR90","doi-asserted-by":"publisher","first-page":"813","DOI":"10.3389\/fnins.2018.00813","volume":"12","author":"JM Gaspar","year":"2018","unstructured":"Gaspar JM, Velloso LA (2018) Hypoxia inducible factor as a central regulator of metabolism\u2013implications for the development of obesity. Front Neurosci 12:813","journal-title":"Front Neurosci"},{"issue":"1","key":"73_CR91","doi-asserted-by":"publisher","first-page":"2999","DOI":"10.1038\/s41467-021-22579-1","volume":"12","author":"A Georgiadi","year":"2021","unstructured":"Georgiadi A, Lopez-Salazar V, Merahbi RE, Karikari RA, Ma X, Mour\u00e3o A et al (2021) Orphan GPR116 mediates the insulin sensitizing effects of the hepatokine FNDC4 in adipose tissue. Nat Commun 12(1):2999","journal-title":"Nat Commun"},{"issue":"8","key":"73_CR92","doi-asserted-by":"publisher","first-page":"1319","DOI":"10.1161\/CIRCRESAHA.110.217117","volume":"106","author":"P Geraldes","year":"2010","unstructured":"Geraldes P, King GL (2010) Activation of protein kinase C isoforms and its impact on diabetic complications. Circ Res 106(8):1319\u20131331","journal-title":"Circ Res"},{"issue":"8","key":"73_CR93","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.3324\/haematol.2011.054916","volume":"97","author":"AJ Gerrits","year":"2012","unstructured":"Gerrits AJ, Gitz E, Koekman CA, Visseren FL, van Haeften TW, Akkerman JWN (2012) Induction of insulin resistance by the adipokines resistin, leptin, plasminogen activator inhibitor-1 and retinol binding protein 4 in human megakaryocytes. Haematologica 97(8):1149\u20131157","journal-title":"Haematologica"},{"issue":"6","key":"73_CR94","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/nrd.2016.31","volume":"15","author":"A Giordano","year":"2016","unstructured":"Giordano A, Frontini A, Cinti S (2016) Convertible visceral fat as a therapeutic target to curb obesity. Nat Rev Drug Discov 15(6):405\u2013424","journal-title":"Nat Rev Drug Discov"},{"issue":"1","key":"73_CR95","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1111\/j.1365-201X.2004.01385.x","volume":"183","author":"F Giorgino","year":"2005","unstructured":"Giorgino F, Laviola L, Eriksson JW (2005) Regional differences of insulin action in adipose tissue: insights from in vivo and in vitro studies. Acta Physiol Scand 183(1):13\u201330","journal-title":"Acta Physiol Scand"},{"issue":"2","key":"73_CR96","doi-asserted-by":"publisher","first-page":"e1001485","DOI":"10.1371\/journal.pbio.1001485","volume":"11","author":"A Girousse","year":"2013","unstructured":"Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, Dinel A-L et al (2013) Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass. PLoS Biol 11(2):e1001485","journal-title":"PLoS Biol"},{"issue":"1","key":"73_CR97","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1023\/A:1006812218502","volume":"182","author":"BJ Goldstein","year":"1998","unstructured":"Goldstein BJ, Ahmad F, Ding W, Li P-M, Zhang W-R (1998) Regulation of the insulin signalling pathway by cellular protein-tyrosine phosphatases. Mol Cell Biochem 182(1):91\u201399","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"73_CR98","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/s12933-017-0528-4","volume":"16","author":"N Gonz\u00e1lez","year":"2017","unstructured":"Gonz\u00e1lez N, Moreno-Villegas Z, Gonz\u00e1lez-Bris A, Egido J, Lorenzo \u00d3 (2017) Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes. Cardiovasc Diabetol 16(1):44","journal-title":"Cardiovasc Diabetol"},{"key":"73_CR99","volume-title":"The role of growth hormone in fat mobilization. Designing foods, animal product options in the marketplace","author":"HM Goodman","year":"1988","unstructured":"Goodman HM (1988) The role of growth hormone in fat mobilization. Designing foods, animal product options in the marketplace. National Academy Press, Washington"},{"issue":"5","key":"73_CR100","doi-asserted-by":"publisher","first-page":"2149","DOI":"10.1159\/000489545","volume":"46","author":"H Guan","year":"2018","unstructured":"Guan H, Zhang Y, Gao S, Bai L, Zhao S, Cheng XW et al (2018) Differential patterns of secreted frizzled-related protein 4 (SFRP4) in adipocyte differentiation: adipose depot specificity. Cell Physiol Biochem 46(5):2149\u20132164","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"73_CR101","doi-asserted-by":"publisher","first-page":"637","DOI":"10.3892\/etm.2021.10069","volume":"21","author":"H Guan","year":"2021","unstructured":"Guan H, Zheng H, Zhang J, Xiang A, Li Y, Zheng H et al (2021) Secreted frizzled-related protein 4 promotes brown adipocyte differentiation. Exp Ther Med 21(6):637","journal-title":"Exp Ther Med"},{"issue":"11","key":"73_CR102","doi-asserted-by":"publisher","first-page":"1971","DOI":"10.1016\/j.biochi.2013.07.017","volume":"95","author":"F Guebre-Egziabher","year":"2013","unstructured":"Guebre-Egziabher F, Alix PM, Koppe L, Pelletier CC, Kalbacher E, Fouque D et al (2013) Ectopic lipid accumulation: a potential cause for metabolic disturbances and a contributor to the alteration of kidney function. Biochimie 95(11):1971\u20131979","journal-title":"Biochimie"},{"issue":"2","key":"73_CR103","doi-asserted-by":"publisher","first-page":"E576","DOI":"10.1152\/ajpendo.00523.2006","volume":"293","author":"W Guo","year":"2007","unstructured":"Guo W, Wong S, Xie W, Lei T, Luo Z (2007) Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes. Am J Physiol Endocrinol Metab 293(2):E576\u2013EE86","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"7288","key":"73_CR104","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/nature08816","volume":"464","author":"RK Gupta","year":"2010","unstructured":"Gupta RK, Arany Z, Seale P, Mepani RJ, Ye L, Conroe HM et al (2010) Transcriptional control of preadipocyte determination by Zfp423. Nature 464(7288):619\u2013623","journal-title":"Nature"},{"issue":"7","key":"73_CR105","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.1073\/pnas.1211255110","volume":"110","author":"A Hammarstedt","year":"2013","unstructured":"Hammarstedt A, Hedjazifar S, Jenndahl L, Gogg S, Gr\u00fcnberg J, Gustafson B et al (2013) WISP2 regulates preadipocyte commitment and PPAR\u03b3 activation by BMP4. Proc Natl Acad Sci 110(7):2563\u20132568","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"73_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-23846-x","volume":"12","author":"Y Han","year":"2021","unstructured":"Han Y, Xia G, Srisai D, Meng F, He Y, Ran Y et al (2021) Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding. Nat Commun 12(1):1\u201316","journal-title":"Nat Commun"},{"issue":"5","key":"73_CR107","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.2337\/db15-1372","volume":"65","author":"MJ Hanssen","year":"2016","unstructured":"Hanssen MJ, van der Lans AA, Brans B, Hoeks J, Jardon KM, Schaart G et al (2016) Short-term cold acclimation recruits brown adipose tissue in obese humans. Diabetes 65(5):1179\u20131189","journal-title":"Diabetes"},{"issue":"10","key":"73_CR108","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1038\/nm.3361","volume":"19","author":"M Harms","year":"2013","unstructured":"Harms M, Seale P (2013) Brown and beige fat: development, function and therapeutic potential. Nat Med 19(10):1252\u20131263","journal-title":"Nat Med"},{"issue":"4","key":"73_CR109","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1016\/j.cbpa.2009.08.008","volume":"154","author":"D Hauton","year":"2009","unstructured":"Hauton D, Coney AM, Egginton S (2009) Both substrate availability and utilisation contribute to the defence of core temperature in response to acute cold. Comp Biochem Physiol A Mol Integr Physiol 154(4):514\u2013522","journal-title":"Comp Biochem Physiol A Mol Integr Physiol"},{"issue":"3","key":"73_CR110","doi-asserted-by":"publisher","first-page":"bqab009","DOI":"10.1210\/endocr\/bqab009","volume":"162","author":"I Heyde","year":"2021","unstructured":"Heyde I, Begemann K, Oster H (2021) Contributions of white and brown adipose tissues to the circadian regulation of energy metabolism. Endocrinology 162(3):bqab009","journal-title":"Endocrinology"},{"issue":"21","key":"73_CR111","doi-asserted-by":"publisher","first-page":"15985","DOI":"10.1074\/jbc.275.21.15985","volume":"275","author":"D Hilton","year":"2000","unstructured":"Hilton D, Emanuelli B, Peraldi P, Filloux C, Sawka-Verhelle D, Van Obberghen E (2000) SOCS-3 is an insulin-induced negative regulator of insulin signaling. J Biol Chem 275(21):15985\u201315991","journal-title":"J Biol Chem"},{"issue":"1","key":"73_CR112","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/CIRCRESAHA.115.306647","volume":"118","author":"G Hoeke","year":"2016","unstructured":"Hoeke G, Kooijman S, Boon MR, Rensen PC, Berb\u00e9e JF (2016) Role of brown fat in lipoprotein metabolism and atherosclerosis. Circ Res 118(1):173\u2013182","journal-title":"Circ Res"},{"issue":"6","key":"73_CR113","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1042\/bst0311120","volume":"31","author":"C Holm","year":"2003","unstructured":"Holm C (2003) Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans 31(6):1120\u20131124","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"73_CR114","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1042\/BJ20050216","volume":"388","author":"LJ Holt","year":"2005","unstructured":"Holt LJ, Siddle K (2005) Grb10 and Grb14: enigmatic regulators of insulin action \u2013 and more? Biochem J 388(2):393\u2013406","journal-title":"Biochem J"},{"issue":"6035","key":"73_CR115","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1126\/science.1199498","volume":"332","author":"PP Hsu","year":"2011","unstructured":"Hsu PP, Kang SA, Rameseder J, Zhang Y, Ottina KA, Lim D et al (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332(6035):1317\u20131322","journal-title":"Science"},{"issue":"12","key":"73_CR116","doi-asserted-by":"publisher","first-page":"1454","DOI":"10.1038\/nm.4429","volume":"23","author":"K Ikeda","year":"2017","unstructured":"Ikeda K, Kang Q, Yoneshiro T, Camporez JP, Maki H, Homma M et al (2017) UCP1-independent signaling involving SERCA2b-mediated calcium cycling regulates beige fat thermogenesis and systemic glucose homeostasis. Nat Med 23(12):1454\u20131465","journal-title":"Nat Med"},{"issue":"3","key":"73_CR117","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.tem.2018.01.001","volume":"29","author":"K Ikeda","year":"2018","unstructured":"Ikeda K, Maretich P, Kajimura S (2018) The common and distinct features of brown and beige adipocytes. Trends Endocrinol Metab 29(3):191\u2013200. https:\/\/doi.org\/10.1016\/j.tem.2018.01.001","journal-title":"Trends Endocrinol Metab"},{"issue":"8","key":"73_CR118","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1038\/nrm.2016.62","volume":"17","author":"T Inagaki","year":"2016","unstructured":"Inagaki T, Sakai J, Kajimura S (2016) Transcriptional and epigenetic control of brown and beige adipose cell fate and function. Nat Rev Mol Cell Biol 17(8):480\u2013495","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"11","key":"73_CR119","doi-asserted-by":"publisher","first-page":"4226","DOI":"10.1210\/jc.2017-01250","volume":"102","author":"KA Iwen","year":"2017","unstructured":"Iwen KA, Backhaus J, Cassens M, Waltl M, Hedesan OC, Merkel M et al (2017) Cold-induced brown adipose tissue activity alters plasma fatty acids and improves glucose metabolism in men. J Clin Endocrinol Metabol 102(11):4226\u20134234","journal-title":"J Clin Endocrinol Metabol"},{"issue":"11 Suppl 1","key":"73_CR120","doi-asserted-by":"publisher","first-page":"S57","DOI":"10.1210\/jc.2008-1585","volume":"93","author":"MD Jensen","year":"2008","unstructured":"Jensen MD (2008) Role of body fat distribution and the metabolic complications of obesity. J Clin Endocrinol Metab 93(11 Suppl 1):S57\u2013S63","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"73_CR121","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1172\/JCI113997","volume":"83","author":"MD Jensen","year":"1989","unstructured":"Jensen MD, Haymond MW, Rizza RA, Cryer PE, Miles J (1989) Influence of body fat distribution on free fatty acid metabolism in obesity. J Clin Invest 83(4):1168\u20131173","journal-title":"J Clin Invest"},{"issue":"4","key":"73_CR122","doi-asserted-by":"publisher","first-page":"109459","DOI":"10.1016\/j.celrep.2021.109459","volume":"36","author":"SM Jung","year":"2021","unstructured":"Jung SM, Doxsey WG, Le J, Haley JA, Mazuecos L, Luciano AK et al (2021) In vivo isotope tracing reveals the versatility of glucose as a brown adipose tissue substrate. Cell Rep 36(4):109459","journal-title":"Cell Rep"},{"issue":"4","key":"73_CR123","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1016\/j.cmet.2015.09.007","volume":"22","author":"S Kajimura","year":"2015","unstructured":"Kajimura S, Spiegelman Bruce M, Seale P (2015) Brown and beige fat: physiological roles beyond heat generation. Cell Metab 22(4):546\u2013559","journal-title":"Cell Metab"},{"issue":"1","key":"73_CR124","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/2042-6410-3-13","volume":"3","author":"K Karastergiou","year":"2012","unstructured":"Karastergiou K, Smith SR, Greenberg AS, Fried SK (2012) Sex differences in human adipose tissues \u2013 the biology of pear shape. Biol Sex Differ 3(1):13","journal-title":"Biol Sex Differ"},{"issue":"19","key":"73_CR125","doi-asserted-by":"publisher","first-page":"3059","DOI":"10.1091\/mbc.e14-06-1060","volume":"25","author":"S Karunanithi","year":"2014","unstructured":"Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen X-W et al (2014) A Rab10: RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes. Mol Biol Cell 25(19):3059\u20133069","journal-title":"Mol Biol Cell"},{"issue":"3","key":"73_CR126","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.cell.2015.09.035","volume":"163","author":"L Kazak","year":"2015","unstructured":"Kazak L, Chouchani ET, Jedrychowski MP, Erickson BK, Shinoda K, Cohen P et al (2015) A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat. Cell 163(3):643\u2013655","journal-title":"Cell"},{"issue":"7884","key":"73_CR127","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/s41586-021-04019-8","volume":"599","author":"O Keinan","year":"2021","unstructured":"Keinan O, Valentine JM, Xiao H, Mahata SK, Reilly SM, Abu-Odeh M et al (2021) Glycogen metabolism links glucose homeostasis to thermogenesis in adipocytes. Nature 599(7884):296\u2013301","journal-title":"Nature"},{"key":"73_CR128","doi-asserted-by":"publisher","first-page":"111337","DOI":"10.1016\/j.mce.2021.111337","volume":"533","author":"M Keuper","year":"2021","unstructured":"Keuper M, Jastroch M (2021) The good and the BAT of metabolic sex differences in thermogenic human adipose tissue. Mol Cell Endocrinol 533:111337","journal-title":"Mol Cell Endocrinol"},{"issue":"2","key":"73_CR129","doi-asserted-by":"publisher","first-page":"271","DOI":"10.33549\/physiolres.932997","volume":"65","author":"H-J Kim","year":"2016","unstructured":"Kim H-J, Lee H-J, So B, Son JS, Yoon D, Song W (2016) Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight\/obese adults: a pilot study. Physiol Res 65(2):271","journal-title":"Physiol Res"},{"issue":"9","key":"73_CR130","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1194\/jlr.M085647","volume":"59","author":"J Kim","year":"2018","unstructured":"Kim J, Park MS, Ha K, Park C, Lee J, Mynatt RL et al (2018) NT-PGC-1\u03b1 deficiency decreases mitochondrial FA oxidation in brown adipose tissue and alters substrate utilization in vivo. J Lipid Res 59(9):1660\u20131670. https:\/\/doi.org\/10.1194\/jlr.M085647","journal-title":"J Lipid Res"},{"issue":"3","key":"73_CR131","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1101\/gad.177857.111","volume":"26","author":"S Kleiner","year":"2012","unstructured":"Kleiner S, Douris N, Fox EC, Mepani RJ, Verdeguer F, Wu J et al (2012) FGF21 regulates PGC-1\u03b1 and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 26(3):271\u2013281","journal-title":"Genes Dev"},{"issue":"1","key":"73_CR132","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.cell.2014.04.049","volume":"158","author":"X Kong","year":"2014","unstructured":"Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P et al (2014) IRF4 is a key thermogenic transcriptional partner of PGC-1\u03b1. Cell 158(1):69\u201383","journal-title":"Cell"},{"issue":"2","key":"73_CR133","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1096\/fj.201800792R","volume":"33","author":"Y Kou","year":"2019","unstructured":"Kou Y, Liu Q, Liu W, Sun H, Liang M, Kong F et al (2019) LIGHT\/TNFSF14 signaling attenuates beige fat biogenesis. FASEB J 33(2):1595\u20131604","journal-title":"FASEB J"},{"key":"73_CR134","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1007\/978-1-4939-2895-8_5","volume":"872","author":"T Kuo","year":"2015","unstructured":"Kuo T, McQueen A, Chen T-C, Wang J-C (2015) Regulation of glucose homeostasis by glucocorticoids. Adv Exp Med Biol 872:99\u2013126","journal-title":"Adv Exp Med Biol"},{"key":"73_CR135","unstructured":"Kyrou I, Randeva HS, Tsigos C, Kaltsas G, Weickert MO (2018) Clinical problems caused by obesity. Endotext"},{"key":"73_CR136","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3389\/fnsys.2015.00150","volume":"9","author":"SM Labb\u00e9","year":"2015","unstructured":"Labb\u00e9 SM, Caron A, Lanfray D, Monge-Rofarello B, Bartness TJ, Richard D (2015) Hypothalamic control of brown adipose tissue thermogenesis. Front Syst Neurosci 9:150","journal-title":"Front Syst Neurosci"},{"issue":"2","key":"73_CR137","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.numecd.2006.10.005","volume":"17","author":"M Laclaustra","year":"2007","unstructured":"Laclaustra M, Corella D, Ordovas JM (2007) Metabolic syndrome pathophysiology: the role of adipose tissue. Nutr Metab Cardiovasc Dis 17(2):125\u2013139","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"10","key":"73_CR138","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1161\/01.ATV.0000183728.14712.d8","volume":"25","author":"M Lafontan","year":"2005","unstructured":"Lafontan M, Moro C, Sengenes C, Galitzky J, Crampes F, Berlan M (2005) An unsuspected metabolic role for atrial natriuretic peptides. Arterioscler Thromb Vasc Biol 25(10):2032\u20132042","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"73_CR139","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/B978-0-12-375003-7.00006-6","volume":"94","author":"MB Lanktree","year":"2010","unstructured":"Lanktree MB, Johansen CT, Joy TR, Hegele RA (2010) A translational view of the genetics of lipodystrophy and ectopic fat deposition. Prog Mol Biol Transl Sci 94:159\u2013196","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"4","key":"73_CR140","doi-asserted-by":"publisher","first-page":"952","DOI":"10.2337\/diabetes.55.04.06.db05-1414","volume":"55","author":"L Laviola","year":"2006","unstructured":"Laviola L, Perrini S, Cignarelli A, Natalicchio A, Leonardini A, De Stefano F et al (2006) Insulin signaling in human visceral and subcutaneous adipose tissue in vivo. Diabetes 55(4):952\u2013961","journal-title":"Diabetes"},{"issue":"3","key":"73_CR141","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1016\/j.bbadis.2013.05.011","volume":"1842","author":"Y-H Lee","year":"2014","unstructured":"Lee Y-H, Mottillo EP, Granneman JG (2014a) Adipose tissue plasticity from WAT to BAT and in between. Biochim Biophys Acta 1842(3):358\u2013369","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"73_CR142","doi-asserted-by":"publisher","first-page":"e78","DOI":"10.1038\/emm.2013.163","volume":"46","author":"Y-H Lee","year":"2014","unstructured":"Lee Y-H, Jung Y-S, Choi D (2014b) Recent advance in brown adipose physiology and its therapeutic potential. Exp Mol Med 46(2):e78","journal-title":"Exp Mol Med"},{"issue":"1\u20132","key":"73_CR143","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.cell.2014.12.011","volume":"160","author":"M-W Lee","year":"2015","unstructured":"Lee M-W, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC et al (2015) Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell 160(1\u20132):74\u201387","journal-title":"Cell"},{"issue":"4","key":"73_CR144","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.cmet.2016.02.007","volume":"23","author":"P Lee","year":"2016","unstructured":"Lee P, Bova R, Schofield L, Bryant W, Dieckmann W, Slattery A et al (2016) Brown adipose tissue exhibits a glucose-responsive thermogenic biorhythm in humans. Cell Metab 23(4):602\u2013609","journal-title":"Cell Metab"},{"issue":"19","key":"73_CR145","doi-asserted-by":"publisher","first-page":"4924","DOI":"10.3390\/ijms20194924","volume":"20","author":"JH Lee","year":"2019","unstructured":"Lee JH, Park A, Oh K-J, Lee SC, Kim WK, Bae K-H (2019) The role of adipose tissue mitochondria: regulation of mitochondrial function for the treatment of metabolic diseases. Int J Mol Sci 20(19):4924","journal-title":"Int J Mol Sci"},{"issue":"6","key":"73_CR146","doi-asserted-by":"publisher","first-page":"1610","DOI":"10.1016\/j.celrep.2018.07.019","volume":"24","author":"OM Leung","year":"2018","unstructured":"Leung OM, Li J, Li X, Chan VW, Yang KY, Ku M et al (2018) Regulatory T cells promote apelin-mediated sprouting angiogenesis in type 2 diabetes. Cell Rep 24(6):1610\u20131626","journal-title":"Cell Rep"},{"issue":"4","key":"73_CR147","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1177\/147323000803600402","volume":"36","author":"Q Li","year":"2008","unstructured":"Li Q, Chen R, Moriya J, Yamakawa J, Sumino H, Kanda T et al (2008) A novel adipocytokine, visceral adipose tissue-derived serine protease inhibitor (vaspin), and obesity. J Int Med Res 36(4):625\u2013629","journal-title":"J Int Med Res"},{"issue":"853","key":"73_CR148","first-page":"1","volume":"15","author":"S Li","year":"2019","unstructured":"Li S, Huang Q, Zhang L, Qiao X, Zhang Y, Tang F et al (2019) Effect of CAPE-pNO2 against type 2 diabetes mellitus via the AMPK\/GLUT4\/GSK3beta\/PPARalpha pathway in HFD\/STZ-induced diabetic mice. Eur J Pharmacol 15(853):1\u201310","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"73_CR149","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1530\/JOE-19-0447","volume":"245","author":"Z-Z Liao","year":"2020","unstructured":"Liao Z-Z, Qi X-Y, Wang Y-D, Li J-Y, Gu Q-Q, Hu C et al (2020) Betatrophin knockdown induces beiging and mitochondria biogenesis of white adipocytes. J Endocrinol 245(1):93\u2013100","journal-title":"J Endocrinol"},{"key":"73_CR150","doi-asserted-by":"crossref","unstructured":"Lim K, Haider A, Adams C, Sleigh A, Savage D (2020) Lipodystrophy: a paradigm for understanding the consequences of \u201coverloading\u201d adipose tissue. Physiol Rev","DOI":"10.1152\/physrev.00032.2020"},{"issue":"6","key":"73_CR151","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.cmet.2014.03.018","volume":"19","author":"M Liu","year":"2014","unstructured":"Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C et al (2014) Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1. Cell Metab 19(6):967\u2013980","journal-title":"Cell Metab"},{"issue":"1","key":"73_CR152","doi-asserted-by":"publisher","first-page":"5070","DOI":"10.1038\/s41467-019-12988-8","volume":"10","author":"P Liu","year":"2019","unstructured":"Liu P, Huang S, Ling S, Xu S, Wang F, Zhang W et al (2019) Foxp1 controls brown\/beige adipocyte differentiation and thermogenesis through regulating \u03b23-AR desensitization. Nat Commun 10(1):5070","journal-title":"Nat Commun"},{"issue":"1","key":"73_CR153","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3390\/cells9010201","volume":"9","author":"J Liu","year":"2020","unstructured":"Liu J, Zhang C, Zhang B, Sheng Y, Xu W, Luo Y et al (2020) Comprehensive analysis of the characteristics and differences in adult and newborn brown adipose tissue (BAT): newborn BAT is a more active\/dynamic BAT. Cell 9(1):201","journal-title":"Cell"},{"issue":"4","key":"73_CR154","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1210\/jc.2014-2932","volume":"100","author":"D L\u00f6ffler","year":"2015","unstructured":"L\u00f6ffler D, M\u00fcller U, Scheuermann K, Friebe D, Gesing J, Bielitz J et al (2015) Serum irisin levels are regulated by acute strenuous exercise. J Clin Endocrinol Metabol 100(4):1289\u20131299","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"73_CR155","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1101\/gad.250829.114","volume":"29","author":"A Loft","year":"2015","unstructured":"Loft A, Forss I, Siersbaek MS, Schmidt SF, Larsen AS, Madsen JG et al (2015) Browning of human adipocytes requires KLF11 and reprogramming of PPARgamma superenhancers. Genes Dev 29(1):7\u201322","journal-title":"Genes Dev"},{"issue":"5","key":"73_CR156","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.cmet.2014.03.025","volume":"19","author":"JZ Long","year":"2014","unstructured":"Long JZ, Svensson KJ, Tsai L, Zeng X, Roh HC, Kong X et al (2014) A smooth muscle-like origin for beige adipocytes. Cell Metab 19(5):810\u2013820","journal-title":"Cell Metab"},{"issue":"3","key":"73_CR157","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.kint.2020.03.027","volume":"98","author":"M Luce","year":"2020","unstructured":"Luce M, Barba C, Yi D, Mey A, Roussel D, Bres E et al (2020) Accumulation of natriuretic peptides is associated with protein energy wasting and activation of browning in white adipose tissue in chronic kidney disease. Kidney Int 98(3):663\u2013672","journal-title":"Kidney Int"},{"issue":"1","key":"73_CR158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-74588-7","volume":"10","author":"Y Luo","year":"2020","unstructured":"Luo Y, Qiao X, Ma Y, Deng H, Xu CC, Xu L (2020) Disordered metabolism in mice lacking irisin. Sci Rep 10(1):1\u201310","journal-title":"Sci Rep"},{"issue":"2","key":"73_CR159","doi-asserted-by":"publisher","first-page":"23","DOI":"10.3390\/biology8020023","volume":"8","author":"Q Luong","year":"2019","unstructured":"Luong Q, Huang J, Lee KY (2019) Deciphering white adipose tissue heterogeneity. Biology 8(2):23","journal-title":"Biology"},{"issue":"45","key":"73_CR160","doi-asserted-by":"publisher","first-page":"23390","DOI":"10.1074\/jbc.M116.735563","volume":"291","author":"Y Lv","year":"2016","unstructured":"Lv Y, Zhang S-Y, Liang X, Zhang H, Xu Z, Liu B et al (2016) Adrenomedullin 2 enhances beiging in white adipose tissue directly in an adipocyte-autonomous manner and indirectly through activation of M2 macrophages. J Biol Chem 291(45):23390\u201323402","journal-title":"J Biol Chem"},{"key":"73_CR161","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fendo.2015.00001","volume":"6","author":"X Ma","year":"2015","unstructured":"Ma X, Lee P, Chisholm DJ, James DE (2015) Control of adipocyte differentiation in different fat depots; implications for pathophysiology or therapy. Front Endocrinol 6:1","journal-title":"Front Endocrinol"},{"key":"73_CR162","doi-asserted-by":"publisher","first-page":"6561726","DOI":"10.1155\/2019\/6561726","volume":"2019","author":"G-E Maalouf","year":"2019","unstructured":"Maalouf G-E, El Khoury D (2019) Exercise-induced irisin, the fat browning myokine, as a potential anticancer agent. J Obes 2019:6561726","journal-title":"J Obes"},{"issue":"1","key":"73_CR163","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cmet.2016.08.016","volume":"25","author":"K Man","year":"2017","unstructured":"Man K, Kutyavin VI, Chawla A (2017) Tissue immunometabolism: development, physiology, and pathobiology. Cell Metab 25(1):11\u201326","journal-title":"Cell Metab"},{"key":"73_CR164","doi-asserted-by":"publisher","first-page":"e0185624","DOI":"10.1371\/journal.pone.0185624","volume":"12","author":"L Markussen","year":"2017","unstructured":"Markussen L, Isidor M, Breining P, Andersen E, Rasmussen N, Petersen L et al (2017) Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. PLoS One 12:e0185624","journal-title":"PLoS One"},{"issue":"4","key":"73_CR165","doi-asserted-by":"publisher","first-page":"701","DOI":"10.3390\/ijms18040701","volume":"18","author":"AI Mazur-Bialy","year":"2017","unstructured":"Mazur-Bialy AI, Poche\u0107 E, Zarawski M (2017) Anti-inflammatory properties of irisin, mediator of physical activity, are connected with TLR4\/MyD88 signaling pathway activation. Int J Mol Sci 18(4):701","journal-title":"Int J Mol Sci"},{"issue":"2","key":"73_CR166","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3168\/jds.S0022-0302(91)78217-9","volume":"74","author":"J McNamara","year":"1991","unstructured":"McNamara J (1991) Regulation of adipose tissue metabolism in support of lactation. J Dairy Sci 74(2):706\u2013719","journal-title":"J Dairy Sci"},{"key":"73_CR167","doi-asserted-by":"crossref","unstructured":"McNeill BT, Morton NM, Stimson RH (2020) Substrate utilization by brown adipose tissue: what\u2019s hot and what\u2019s not? Front Endocrinol 11(785)","DOI":"10.3389\/fendo.2020.571659"},{"key":"73_CR168","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.mito.2021.05.001","volume":"59","author":"SS Michurina","year":"2021","unstructured":"Michurina SS, Stafeev IS, Menshikov MY, Parfyonova YV (2021) Mitochondrial dynamics keep balance of nutrient combustion in thermogenic adipocytes. Mitochondrion 59:157\u2013168","journal-title":"Mitochondrion"},{"issue":"8","key":"73_CR169","doi-asserted-by":"publisher","first-page":"2958","DOI":"10.1210\/jc.2008-2297","volume":"94","author":"P Mitrou","year":"2009","unstructured":"Mitrou P, Boutati E, Lambadiari V, Maratou E, Papakonstantinou A, Komesidou V et al (2009) Rates of glucose uptake in adipose tissue and muscle in vivo after a mixed meal in women with morbid obesity. J Clin Endocrinol Metabol 94(8):2958\u20132961","journal-title":"J Clin Endocrinol Metabol"},{"issue":"2","key":"73_CR170","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1210\/er.2008-0027","volume":"30","author":"N M\u00f8ller","year":"2009","unstructured":"M\u00f8ller N, J\u00f8rgensen JOL (2009) Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev 30(2):152\u2013177","journal-title":"Endocr Rev"},{"issue":"52","key":"73_CR171","doi-asserted-by":"publisher","first-page":"43109","DOI":"10.1074\/jbc.M506336200","volume":"280","author":"H-PH Moore","year":"2005","unstructured":"Moore H-PH, Silver RB, Mottillo EP, Bernlohr DA, Granneman JG (2005) Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase. J Biol Chem 280(52):43109\u201343120","journal-title":"J Biol Chem"},{"key":"73_CR172","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41574-021-00471-8","volume":"17","author":"P Morigny","year":"2021","unstructured":"Morigny P, Boucher J, Arner P, Langin D (2021) Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nat Rev Endocrinol 17:1\u201320","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"73_CR173","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3390\/ijms17010124","volume":"17","author":"D Moseti","year":"2016","unstructured":"Moseti D, Regassa A, Kim W-K (2016) Molecular regulation of adipogenesis and potential anti-adipogenic bioactive molecules. Int J Mol Sci 17(1):124","journal-title":"Int J Mol Sci"},{"key":"73_CR174","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fendo.2016.00019","volume":"7","author":"E Mueller","year":"2016","unstructured":"Mueller E (2016) Browning and graying: novel transcriptional regulators of brown and beige fat tissues and aging. Front Endocrinol 7:19","journal-title":"Front Endocrinol"},{"key":"73_CR175","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.phrs.2016.12.022","volume":"116","author":"S Mukaida","year":"2017","unstructured":"Mukaida S, Evans BA, Bengtsson T, Hutchinson DS, Sato M (2017) Adrenoceptors promote glucose uptake into adipocytes and muscle by an insulin-independent signaling pathway involving mechanistic target of rapamycin complex 2. Pharmacol Res 116:87\u201392","journal-title":"Pharmacol Res"},{"issue":"9","key":"73_CR176","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1038\/s42255-020-0258-x","volume":"2","author":"RM Murphy","year":"2020","unstructured":"Murphy RM, Watt MJ, Febbraio MA (2020) Metabolic communication during exercise. Nat Metab 2(9):805\u2013816","journal-title":"Nat Metab"},{"key":"73_CR177","doi-asserted-by":"crossref","unstructured":"Nanduri R (2021) Epigenetic regulators of white adipocyte browning. Epigenomes 5","DOI":"10.3390\/epigenomes5010003"},{"key":"73_CR178","doi-asserted-by":"crossref","unstructured":"Nedergaard J, Bengtsson T, Cannon B (2007) Unexpected evidence for active brown adipose tissue in adult humans. Am J Physiol","DOI":"10.1152\/ajpendo.00691.2006"},{"key":"73_CR179","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ejro.2018.08.002","volume":"5","author":"Y Ogawa","year":"2018","unstructured":"Ogawa Y, Abe K, Sakoda A, Onizuka H, Sakai S (2018) FDG-PET and CT findings of activated brown adipose tissue in a patient with paraganglioma. Eur J Radiol Open 5:126\u2013130","journal-title":"Eur J Radiol Open"},{"issue":"8","key":"73_CR180","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1113\/jphysiol.2013.270256","volume":"592","author":"J Olesen","year":"2014","unstructured":"Olesen J, Gliemann L, Biens\u00f8 R, Schmidt J, Hellsten Y, Pilegaard H (2014) Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol 592(8):1873\u20131886","journal-title":"J Physiol"},{"issue":"3","key":"73_CR181","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1083\/jcb.201403080","volume":"207","author":"JM Olsen","year":"2014","unstructured":"Olsen JM, Sato M, Dallner OS, Sandstr\u00f6m AL, Pisani DF, Chambard J-C et al (2014) Glucose uptake in brown fat cells is dependent on mTOR complex 2\u2013promoted GLUT1 translocation. J Cell Biol 207(3):365\u2013374","journal-title":"J Cell Biol"},{"issue":"13","key":"73_CR182","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.1042\/BCJ20190462","volume":"477","author":"Y Onogi","year":"2020","unstructured":"Onogi Y, Khalil AEMM, Ussar S (2020) Identification and characterization of adipose surface epitopes. Biochem J 477(13):2509\u20132541","journal-title":"Biochem J"},{"issue":"1-2","key":"73_CR183","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/0165-5728(95)00066-B","volume":"60","author":"M Opp","year":"1995","unstructured":"Opp M, Smith E, Hughes T Jr (1995) Interleukin-10 (cytokine synthesis inhibitory factor) acts in the central nervous system of rats to reduce sleep. J Neuroimmunol 60(1-2):165\u2013168","journal-title":"J Neuroimmunol"},{"issue":"8","key":"73_CR184","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1056\/NEJMoa012437","volume":"346","author":"EA Oral","year":"2002","unstructured":"Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P et al (2002) Leptin-replacement therapy for lipodystrophy. N Engl J Med 346(8):570\u2013578","journal-title":"N Engl J Med"},{"issue":"1","key":"73_CR185","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1186\/s12933-018-0762-4","volume":"17","author":"V Ormazabal","year":"2018","unstructured":"Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zu\u00f1iga FA (2018) Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol 17(1):122","journal-title":"Cardiovasc Diabetol"},{"issue":"3","key":"73_CR186","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1111\/j.1469-7793.1998.889ba.x","volume":"513","author":"K Ostrowski","year":"1998","unstructured":"Ostrowski K, Hermann C, Bangash A, Schjerling P, Nielsen JN, Pedersen BK (1998) A trauma-like elevation of plasma cytokines in humans in response to treadmill running. J Physiol 513(3):889\u2013894","journal-title":"J Physiol"},{"issue":"1","key":"73_CR187","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/s42003-021-01858-z","volume":"4","author":"L Pajed","year":"2021","unstructured":"Pajed L, Taschler U, Tilp A, Hofer P, Kotzbeck P, Kolleritsch S et al (2021) Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase. Commun Biol 4(1):323","journal-title":"Commun Biol"},{"issue":"11","key":"73_CR188","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1007\/s00125-012-2665-3","volume":"55","author":"R Palanivel","year":"2012","unstructured":"Palanivel R, Fullerton MD, Galic S, Honeyman J, Hewitt KA, Jorgensen SB et al (2012) Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance. Diabetologia 55(11):3083\u20133093","journal-title":"Diabetologia"},{"issue":"1","key":"73_CR189","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cyto.2012.06.018","volume":"60","author":"J Panee","year":"2012","unstructured":"Panee J (2012) Monocyte chemoattractant protein 1 (MCP-1) in obesity and diabetes. Cytokine 60(1):1\u201312","journal-title":"Cytokine"},{"issue":"2","key":"73_CR190","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1007\/s10522-014-9536-x","volume":"16","author":"C Pararasa","year":"2015","unstructured":"Pararasa C, Bailey CJ, Griffiths HR (2015) Ageing, adipose tissue, fatty acids and inflammation. Biogerontology 16(2):235\u2013248","journal-title":"Biogerontology"},{"issue":"4","key":"73_CR191","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.devcel.2013.07.002","volume":"26","author":"JH Park","year":"2013","unstructured":"Park JH, Kang HJ, Kang SI, Lee JE, Hur J, Ge K et al (2013) A multifunctional protein, EWS, is essential for early brown fat lineage determination. Dev Cell 26(4):393\u2013404","journal-title":"Dev Cell"},{"issue":"6","key":"73_CR192","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.2337\/db16-1081","volume":"66","author":"J Park","year":"2017","unstructured":"Park J, Kim M, Sun K, An YA, Gu X, Scherer PE (2017) VEGF-A\u2013expressing adipose tissue shows rapid beiging and enhanced survival after transplantation and confers IL-4\u2013independent metabolic improvements. Diabetes 66(6):1479\u20131490","journal-title":"Diabetes"},{"issue":"8","key":"73_CR193","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/eci.12781","volume":"47","author":"BK Pedersen","year":"2017","unstructured":"Pedersen BK (2017a) Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. Eur J Clin Invest 47(8):600\u2013611","journal-title":"Eur J Clin Invest"},{"issue":"8","key":"73_CR194","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1111\/eci.12781","volume":"47","author":"BK Pedersen","year":"2017","unstructured":"Pedersen BK (2017b) Anti-inflammatory effects of exercise: role in diabetes and cardiovascular disease. Eur J Clin Invest 47(8):600\u2013611","journal-title":"Eur J Clin Invest"},{"key":"73_CR195","volume-title":"Differences of insulin signalling in human adipose tissue depots in vivo","author":"S Perrini","year":"2003","unstructured":"Perrini S, Laviola L, Belsanti G, Cignarelli A, Cuscito M, Neri V, et al. Differences of insulin signalling in human adipose tissue depots in vivo. 2003"},{"issue":"1","key":"73_CR196","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s00125-007-0841-7","volume":"51","author":"S Perrini","year":"2008","unstructured":"Perrini S, Laviola L, Cignarelli A, Melchiorre M, De Stefano F, Caccioppoli C et al (2008) Fat depot-related differences in gene expression, adiponectin secretion, and insulin action and signalling in human adipocytes differentiated in vitro from precursor stromal cells. Diabetologia 51(1):155\u2013164","journal-title":"Diabetologia"},{"issue":"3","key":"73_CR197","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1016\/j.cmet.2014.06.011","volume":"20","author":"M Petruzzelli","year":"2014","unstructured":"Petruzzelli M, Schweiger M, Schreiber R, Campos-Olivas R, Tsoli M, Allen J et al (2014) A switch from white to brown fat increases energy expenditure in cancer-associated cachexia. Cell Metab 20(3):433\u2013447","journal-title":"Cell Metab"},{"issue":"3","key":"73_CR198","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3390\/biology8030057","volume":"8","author":"KJ Phillips","year":"2019","unstructured":"Phillips KJ (2019) Beige fat, adaptive thermogenesis, and its regulation by exercise and thyroid hormone. Biology 8(3):57","journal-title":"Biology"},{"key":"73_CR199","doi-asserted-by":"crossref","unstructured":"Piccirillo R (2019) Exercise-induced myokines with therapeutic potential for muscle wasting. Front Physiol 10(287)","DOI":"10.3389\/fphys.2019.00287"},{"issue":"3","key":"73_CR200","doi-asserted-by":"publisher","first-page":"603","DOI":"10.20960\/nh.438","volume":"34","author":"MAS Pinhel","year":"2017","unstructured":"Pinhel MAS, Noronha NY, Nicoletti CF, Quinhoneiro DCG, Oliveira BAP, Cortes-Oliveira C et al (2017) Comparison of gene expression profile between blood cells and white adipose tissue of patients with obesity. Nutr Hosp 34(3):603\u2013607","journal-title":"Nutr Hosp"},{"issue":"3","key":"73_CR201","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1038\/oby.2007.110","volume":"16","author":"KE Pinnick","year":"2008","unstructured":"Pinnick KE, Collins SC, Londos C, Gauguier D, Clark A, Fielding BA (2008) Pancreatic ectopic fat is characterized by adipocyte infiltration and altered lipid composition. Obesity 16(3):522\u2013530","journal-title":"Obesity"},{"issue":"11","key":"73_CR202","doi-asserted-by":"publisher","first-page":"3700","DOI":"10.2337\/db15-0210","volume":"64","author":"A-L Poher","year":"2015","unstructured":"Poher A-L, Veyrat-Durebex C, Altirriba J, Montet X, Colin DJ, Caillon A et al (2015) Ectopic UCP1 overexpression in white adipose tissue improves insulin sensitivity in Lou\/C rats, a model of obesity resistance. Diabetes 64(11):3700\u20133712","journal-title":"Diabetes"},{"issue":"1","key":"73_CR203","first-page":"63","volume":"48","author":"C Purcell","year":"2019","unstructured":"Purcell C, Taylor SM (2019) Idiopathic facial lipoatrophy in a healthy middle-aged woman: a case report. J Otolaryngol 48(1):63","journal-title":"J Otolaryngol"},{"issue":"9","key":"73_CR204","doi-asserted-by":"publisher","first-page":"E798","DOI":"10.1073\/pnas.1215236110","volume":"110","author":"S-W Qian","year":"2013","unstructured":"Qian S-W, Tang Y, Li X, Liu Y, Zhang Y-Y, Huang H-Y et al (2013) BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci 110(9):E798\u2013E807","journal-title":"Proc Natl Acad Sci"},{"key":"73_CR205","doi-asserted-by":"crossref","unstructured":"Rabiee A (2020) Beige fat maintenance; toward a sustained metabolic health. Front Endocrinol 11(634)","DOI":"10.3389\/fendo.2020.00634"},{"issue":"6","key":"73_CR206","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/j.cell.2014.03.065","volume":"157","author":"RR Rao","year":"2014","unstructured":"Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I et al (2014) Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157(6):1279\u20131291","journal-title":"Cell"},{"issue":"2","key":"73_CR207","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.mce.2009.06.005","volume":"316","author":"T Reinehr","year":"2010","unstructured":"Reinehr T (2010) Obesity and thyroid function. Mol Cell Endocrinol 316(2):165\u2013171","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"73_CR208","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1038\/s41467-021-21813-0","volume":"12","author":"CME Remie","year":"2021","unstructured":"Remie CME, Moonen MPB, Roumans KHM, Nascimento EBM, Gemmink A, Havekes B et al (2021) Metabolic responses to mild cold acclimation in type 2 diabetes patients. Nat Commun 12(1):1516","journal-title":"Nat Commun"},{"issue":"6","key":"73_CR209","doi-asserted-by":"publisher","first-page":"2214","DOI":"10.1152\/japplphysiol.00491.2004","volume":"97","author":"SE Riechman","year":"2004","unstructured":"Riechman SE, Balasekaran G, Roth SM, Ferrell RE (2004) Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses. J Appl Physiol 97(6):2214\u20132219","journal-title":"J Appl Physiol"},{"issue":"2","key":"73_CR210","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1007\/s12020-013-9969-z","volume":"45","author":"A Rinnov","year":"2014","unstructured":"Rinnov A, Yfanti C, Nielsen S, \u00c5kerstr\u00f6m TC, Peijs L, Zankari A et al (2014) Endurance training enhances skeletal muscle interleukin-15 in human male subjects. Endocrine 45(2):271\u2013278","journal-title":"Endocrine"},{"issue":"1","key":"73_CR211","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.cmet.2013.12.003","volume":"19","author":"LD Roberts","year":"2014","unstructured":"Roberts LD, Bostr\u00f6m P, O\u2019Sullivan JF, Schinzel RT, Lewis GD, Dejam A et al (2014) \u03b2-Aminoisobutyric acid induces browning of white fat and hepatic \u03b2-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metab 19(1):96\u2013108","journal-title":"Cell Metab"},{"issue":"2","key":"73_CR212","doi-asserted-by":"publisher","first-page":"e0117841","DOI":"10.1371\/journal.pone.0117841","volume":"10","author":"D Rockstroh","year":"2015","unstructured":"Rockstroh D, Landgraf K, Wagner IV, Gesing J, Tauscher R, Lakowa N et al (2015) Direct evidence of brown adipocytes in different fat depots in children. PLoS One 10(2):e0117841","journal-title":"PLoS One"},{"issue":"6","key":"73_CR213","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/s41366-021-00790-w","volume":"45","author":"A Rodgers","year":"2021","unstructured":"Rodgers A, Sferruzzi-Perri AN (2021) Developmental programming of offspring adipose tissue biology and obesity risk. Int J Obes (Lond) 45(6):1170\u20131192","journal-title":"Int J Obes (Lond)"},{"issue":"3","key":"73_CR214","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/ijo.2014.166","volume":"39","author":"A Rodr\u00edguez","year":"2015","unstructured":"Rodr\u00edguez A, Becerril S, M\u00e9ndez-Gim\u00e9nez L, Ram\u00edrez B, S\u00e1inz N, Catal\u00e1n V et al (2015) Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice. Int J Obes (Lond) 39(3):397\u2013407","journal-title":"Int J Obes (Lond)"},{"issue":"2","key":"73_CR215","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1111\/apha.12686","volume":"219","author":"A Rodr\u00edguez","year":"2017","unstructured":"Rodr\u00edguez A, Becerril S, Ezquerro S, M\u00e9ndez-Gim\u00e9nez L, Fr\u00fchbeck G (2017) Crosstalk between adipokines and myokines in fat browning. Acta Physiol 219(2):362\u2013381","journal-title":"Acta Physiol"},{"issue":"3","key":"73_CR216","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/s10552-017-0869-z","volume":"28","author":"I Romieu","year":"2017","unstructured":"Romieu I, Dossus L, Barquera S, Blotti\u00e8re HM, Franks PW, Gunter M et al (2017) Energy balance and obesity: what are the main drivers? Cancer Causes Control 28(3):247\u2013258","journal-title":"Cancer Causes Control"},{"issue":"1","key":"73_CR217","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1385\/ENDO:29:1:81","volume":"29","author":"CM Rondinone","year":"2006","unstructured":"Rondinone CM (2006) Adipocyte-derived hormones, cytokines, and mediators. Endocrine 29(1):81\u201390","journal-title":"Endocrine"},{"issue":"4","key":"73_CR218","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S1097-2765(00)80211-7","volume":"4","author":"ED Rosen","year":"1999","unstructured":"Rosen ED, Sarraf P, Troy AE, Bradwin G, Moore K, Milstone DS et al (1999) PPAR\u03b3 is required for the differentiation of adipose tissue in vivo and in vitro. Mol Cell 4(4):611\u2013617. https:\/\/doi.org\/10.1016\/S1097-2765(00)80211-7","journal-title":"Mol Cell"},{"issue":"19","key":"73_CR219","doi-asserted-by":"publisher","first-page":"12282","DOI":"10.1074\/jbc.M115.637603","volume":"290","author":"LA Rowland","year":"2015","unstructured":"Rowland LA, Bal NC, Kozak LP, Periasamy M (2015) Uncoupling protein 1 and sarcolipin are required to maintain optimal thermogenesis, and loss of both systems compromises survival of mice under cold stress. J Biol Chem 290(19):12282\u201312289","journal-title":"J Biol Chem"},{"issue":"2","key":"73_CR220","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.cell.2014.09.010","volume":"159","author":"H-B Ruan","year":"2014","unstructured":"Ruan H-B, Dietrich MO, Liu Z-W, Zimmer MR, Li M-D, Singh JP et al (2014) O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell 159(2):306\u2013317","journal-title":"Cell"},{"issue":"5","key":"73_CR221","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1210\/jc.2008-2090","volume":"94","author":"T Ruge","year":"2009","unstructured":"Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM et al (2009) Fasted to fed trafficking of fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage. J Clin Endocrinol Metabol 94(5):1781\u20131788","journal-title":"J Clin Endocrinol Metabol"},{"issue":"44","key":"73_CR222","doi-asserted-by":"publisher","first-page":"42394","DOI":"10.1074\/jbc.C200444200","volume":"277","author":"L Rui","year":"2002","unstructured":"Rui L, Yuan M, Frantz D, Shoelson S, White MF (2002) SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J Biol Chem 277(44):42394\u201342398","journal-title":"J Biol Chem"},{"key":"73_CR223","doi-asserted-by":"crossref","unstructured":"Ruigrok SR, St\u00f6berl N, Yam K-Y, de Lucia C, Lucassen PJ, Thuret S et al (2021) Modulation of the hypothalamic nutrient sensing pathways by sex and early-life stress. Front Neurosci 15(914)","DOI":"10.3389\/fnins.2021.695367"},{"key":"73_CR224","doi-asserted-by":"publisher","first-page":"517","DOI":"10.3389\/fendo.2019.00517","volume":"10","author":"B Sahu","year":"2019","unstructured":"Sahu B, Pani S, Swalsingh G, Bal NC (2019) Non and epigenetic mechanisms in regulation of adaptive thermogenesis in skeletal muscle. Front Endocrinol (Lausanne) 10:517","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"73_CR225","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.cmet.2017.10.008","volume":"27","author":"J Sanchez-Gurmaches","year":"2018","unstructured":"Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Calejman CM, Gujja S et al (2018) Brown fat AKT2 is a cold-induced kinase that stimulates ChREBP-mediated de novo lipogenesis to optimize fuel storage and thermogenesis. Cell Metab 27(1):195\u2013209.e6","journal-title":"Cell Metab"},{"issue":"6","key":"73_CR226","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1016\/j.mehy.2013.03.009","volume":"80","author":"R S\u00e1nchez-Jim\u00e9nez","year":"2013","unstructured":"S\u00e1nchez-Jim\u00e9nez R, Alvarado-V\u00e1squez N (2013) IL-15 that a regulator of TNF-\u03b1 in patients with diabetes mellitus type 2. Med Hypotheses 80(6):776\u2013777","journal-title":"Med Hypotheses"},{"issue":"2","key":"73_CR227","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1152\/physrev.00013.2014","volume":"95","author":"DA Sandoval","year":"2015","unstructured":"Sandoval DA, D'Alessio DA (2015) Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiol Rev 95(2):513\u2013548","journal-title":"Physiol Rev"},{"issue":"7","key":"73_CR228","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.2337\/db09-1878","volume":"59","author":"DA Sarruf","year":"2010","unstructured":"Sarruf DA, Thaler JP, Morton GJ, German J, Fischer JD, Ogimoto K et al (2010) Fibroblast growth factor 21 action in the brain increases energy expenditure and insulin sensitivity in obese rats. Diabetes 59(7):1817\u20131824","journal-title":"Diabetes"},{"issue":"2","key":"73_CR229","doi-asserted-by":"publisher","first-page":"108624","DOI":"10.1016\/j.celrep.2020.108624","volume":"34","author":"C Schlein","year":"2021","unstructured":"Schlein C, Fischer AW, Sass F, Worthmann A, T\u00f6dter K, Jaeckstein MY et al (2021) Endogenous fatty acid synthesis drives brown adipose tissue involution. Cell Rep 34(2):108624","journal-title":"Cell Rep"},{"issue":"5","key":"73_CR230","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/j.cmet.2017.09.004","volume":"26","author":"R Schreiber","year":"2017","unstructured":"Schreiber R, Diwoky C, Schoiswohl G, Feiler U, Wongsiriroj N, Abdellatif M et al (2017) Cold-induced thermogenesis depends on ATGL-mediated lipolysis in cardiac muscle, but not Brown adipose tissue. Cell Metab 26(5):753\u201363.e7","journal-title":"Cell Metab"},{"issue":"6","key":"73_CR231","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1007\/BF00868079","volume":"63","author":"HJ Schwandt","year":"1991","unstructured":"Schwandt HJ, Heyduck B, Gunga HC, R\u00f6cker L (1991) Influence of prolonged physical exercise on the erythropoietin concentration in blood. Eur J Appl Physiol Occup Physiol 63(6):463\u2013466","journal-title":"Eur J Appl Physiol Occup Physiol"},{"issue":"1","key":"73_CR232","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-020-15055-9","volume":"11","author":"F Shamsi","year":"2020","unstructured":"Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO et al (2020) FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nat Commun 11(1):1\u201316","journal-title":"Nat Commun"},{"issue":"6","key":"73_CR233","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.cmet.2016.04.023","volume":"23","author":"M Shao","year":"2016","unstructured":"Shao M, Ishibashi J, Kusminski CM, Wang QA, Hepler C, Vishvanath L et al (2016a) Zfp423 maintains white adipocyte identity through suppression of the beige cell thermogenic gene program. Cell Metab 23(6):1167\u20131184. https:\/\/doi.org\/10.1016\/j.cmet.2016.04.023","journal-title":"Cell Metab"},{"issue":"1","key":"73_CR234","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1186\/s12944-016-0310-8","volume":"15","author":"X Shao","year":"2016","unstructured":"Shao X, Yang W, Shao X, Qiu C, Wang X, Wang Y (2016b) The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults. Lipids Health Dis 15(1):138","journal-title":"Lipids Health Dis"},{"issue":"11","key":"73_CR235","doi-asserted-by":"publisher","first-page":"e49452","DOI":"10.1371\/journal.pone.0049452","volume":"7","author":"LZ Sharp","year":"2012","unstructured":"Sharp LZ, Shinoda K, Ohno H, Scheel DW, Tomoda E, Ruiz L et al (2012) Human BAT possesses molecular signatures that resemble beige\/brite cells. PLoS One 7(11):e49452","journal-title":"PLoS One"},{"issue":"3","key":"73_CR236","doi-asserted-by":"publisher","first-page":"699","DOI":"10.2337\/diabetes.55.03.06.db05-0841","volume":"55","author":"H Shi","year":"2006","unstructured":"Shi H, Cave B, Inouye K, Bj\u00f8rb\u00e6k C, Flier JS (2006) Overexpression of suppressor of cytokine signaling 3 in adipose tissue causes local but not systemic insulin resistance. Diabetes 55(3):699\u2013707","journal-title":"Diabetes"},{"issue":"3","key":"73_CR237","doi-asserted-by":"publisher","first-page":"2400","DOI":"10.1016\/j.ygeno.2020.01.012","volume":"112","author":"L Shijun","year":"2020","unstructured":"Shijun L, Khan R, Raza SHA, Jieyun H, Chugang M, Kaster N et al (2020) Function and characterization of the promoter region of perilipin 1 (PLIN1): roles of E2F1, PLAG1, C\/EBP\u03b2, and SMAD3 in bovine adipocytes. Genomics 112(3):2400\u20132409","journal-title":"Genomics"},{"issue":"2","key":"73_CR238","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cmet.2015.06.022","volume":"22","author":"LS Sidossis","year":"2015","unstructured":"Sidossis LS, Porter C, Saraf MK, B\u00f8rsheim E, Radhakrishnan RS, Chao T et al (2015) Browning of subcutaneous white adipose tissue in humans after severe adrenergic stress. Cell Metab 22(2):219\u2013227","journal-title":"Cell Metab"},{"key":"73_CR239","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.metabol.2016.12.012","volume":"69","author":"RG Singh","year":"2017","unstructured":"Singh RG, Yoon HD, Wu LM, Lu J, Plank LD, Petrov MS (2017) Ectopic fat accumulation in the pancreas and its clinical relevance: a systematic review, meta-analysis, and meta-regression. Metabolism 69:1\u201313","journal-title":"Metabolism"},{"key":"73_CR240","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/j.molmet.2018.03.011","volume":"11","author":"AK Singh","year":"2018","unstructured":"Singh AK, Aryal B, Chaube B, Rotllan N, Varela L, Horvath TL et al (2018) Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis. Molecular Metabolism 11:59\u201369","journal-title":"Molecular Metabolism"},{"issue":"2","key":"73_CR241","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1038\/nm1178","volume":"11","author":"MW Sleeman","year":"2005","unstructured":"Sleeman MW, Wortley KE, Lai K-MV, Gowen LC, Kintner J, Kline WO et al (2005) Absence of the lipid phosphatase SHIP2 confers resistance to dietary obesity. Nat Med 11(2):199\u2013205","journal-title":"Nat Med"},{"issue":"16","key":"73_CR242","doi-asserted-by":"publisher","first-page":"5871","DOI":"10.1128\/MCB.02087-06","volume":"27","author":"FM Smith","year":"2007","unstructured":"Smith FM, Holt LJ, Garfield AS, Charalambous M, Koumanov F, Perry M et al (2007) Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life. Mol Cell Biol 27(16):5871\u20135886","journal-title":"Mol Cell Biol"},{"issue":"4","key":"73_CR243","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1210\/er.2017-00211","volume":"39","author":"RL Smith","year":"2018","unstructured":"Smith RL, Soeters MR, W\u00fcst RCI, Houtkooper RH (2018) Metabolic flexibility as an adaptation to energy resources and requirements in health and disease. Endocr Rev 39(4):489\u2013517","journal-title":"Endocr Rev"},{"issue":"5","key":"73_CR244","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.molmet.2015.03.004","volume":"4","author":"G Solinas","year":"2015","unstructured":"Solinas G, Bor\u00e9n J, Dulloo AG (2015) De novo lipogenesis in metabolic homeostasis: more friend than foe? Mol Metab 4(5):367\u2013377","journal-title":"Mol Metab"},{"key":"73_CR245","unstructured":"Stautemas J, Van Kuilenburg A, Stroomer L, Vaz F, Lefevere F, Blancquaert L et al (2018) The acute exercise metabolism of the so-called myokine BAIBA. 23rd annual congress of the European College of Sport Science (ECSS 2018): sport science at the cutting edge, European College of Sport Science"},{"key":"73_CR246","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.3389\/fphys.2019.01240","volume":"10","author":"J Stautemas","year":"2019","unstructured":"Stautemas J, Van Kuilenburg AB, Stroomer L, Vaz F, Blancquaert L, Lefevere FB et al (2019) Acute aerobic exercise leads to increased plasma levels of R-and S-\u03b2-aminoisobutyric acid in humans. Front Physiol 10:1240","journal-title":"Front Physiol"},{"issue":"2","key":"73_CR247","doi-asserted-by":"publisher","first-page":"E433","DOI":"10.1152\/ajpendo.00074.2003","volume":"285","author":"A Steensberg","year":"2003","unstructured":"Steensberg A, Fischer CP, Keller C, M\u00f8ller K, Pedersen BK (2003) IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. Am J Physiol Endocrinol Metab 285(2):E433\u2013E4E7","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"73_CR248","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.peptides.2012.11.014","volume":"39","author":"A Stengel","year":"2013","unstructured":"Stengel A, Hofmann T, Goebel-Stengel M, Elbelt U, Kobelt P, Klapp BF (2013) Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity\u2013correlation with body mass index. Peptides 39:125\u2013130","journal-title":"Peptides"},{"issue":"4","key":"73_CR249","first-page":"468","volume":"34","author":"MAC Stephens","year":"2012","unstructured":"Stephens MAC, Wand G (2012) Stress and the HPA axis: role of glucocorticoids in alcohol dependence. Alcohol Res 34(4):468\u2013483","journal-title":"Alcohol Res"},{"issue":"15","key":"73_CR250","doi-asserted-by":"publisher","first-page":"5874","DOI":"10.1073\/pnas.1200447109","volume":"109","author":"K Sun","year":"2012","unstructured":"Sun K, Asterholm IW, Kusminski CM, Bueno AC, Wang ZV, Pollard JW et al (2012) Dichotomous effects of VEGF-A on adipose tissue dysfunction. Proc Natl Acad Sci 109(15):5874\u20135879","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"73_CR251","doi-asserted-by":"publisher","first-page":"1654","DOI":"10.2337\/db21-0114","volume":"70","author":"HYA Tan","year":"2021","unstructured":"Tan HYA, Sim MFM, Tan S-X, Ng Y, Gan SY, Li H et al (2021) HOXC10 suppresses browning to maintain white adipocyte identity. Diabetes 70(8):1654\u20131663","journal-title":"Diabetes"},{"issue":"23","key":"73_CR252","doi-asserted-by":"publisher","first-page":"22523","DOI":"10.1074\/jbc.M501949200","volume":"280","author":"X Tang","year":"2005","unstructured":"Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A (2005) PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase\/Akt pathway in 3T3-L1 adipocytes. J Biol Chem 280(23):22523\u201322529. https:\/\/doi.org\/10.1074\/jbc.M501949200","journal-title":"J Biol Chem"},{"issue":"2","key":"73_CR253","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1111\/brv.12389","volume":"93","author":"P Tapia","year":"2018","unstructured":"Tapia P, Fern\u00e1ndez-Galilea M, Robledo F, Mardones P, Galgani JE, Cort\u00e9s VA (2018) Biology and pathological implications of brown adipose tissue: promises and caveats for the control of obesity and its associated complications. Biol Rev 93(2):1145\u20131164","journal-title":"Biol Rev"},{"key":"73_CR254","doi-asserted-by":"crossref","unstructured":"Thyagarajan B, Foster MT (2017) Beiging of white adipose tissue as a therapeutic strategy for weight loss in humans. Horm Mol Biol Clin Invest 31(2)","DOI":"10.1515\/hmbci-2017-0016"},{"issue":"6","key":"73_CR255","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1242\/dmm.026609","volume":"10","author":"K Timper","year":"2017","unstructured":"Timper K, Br\u00fcning JC (2017) Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity. Dis Model Mech 10(6):679\u2013689","journal-title":"Dis Model Mech"},{"issue":"4","key":"73_CR256","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1016\/j.tem.2013.12.004","volume":"25","author":"KL Townsend","year":"2014","unstructured":"Townsend KL, Tseng Y-H (2014) Brown fat fuel utilization and thermogenesis. Trends Endocrinol Metab 25(4):168\u2013177","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"73_CR257","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/j.cmet.2012.01.008","volume":"15","author":"K-V Tran","year":"2012","unstructured":"Tran K-V, Gealekman O, Frontini A, Zingaretti MC, Morroni M, Giordano A et al (2012) The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells. Cell Metab 15(2):222\u2013229","journal-title":"Cell Metab"},{"issue":"2","key":"73_CR258","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1620\/tjem.233.135","volume":"233","author":"Y Tsuchiya","year":"2014","unstructured":"Tsuchiya Y, Ando D, Goto K, Kiuchi M, Yamakita M, Koyama K (2014) High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med 233(2):135\u2013140","journal-title":"Tohoku J Exp Med"},{"issue":"247","key":"73_CR259","doi-asserted-by":"publisher","first-page":"247ra103","DOI":"10.1126\/scitranslmed.3008490","volume":"6","author":"S Ussar","year":"2014","unstructured":"Ussar S, Lee KY, Dankel SN, Boucher J, Haering M-F, Kleinridders A et al (2014) ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med 6(247):247ra103","journal-title":"Sci Transl Med"},{"issue":"1","key":"73_CR260","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/biology8010009","volume":"8","author":"P Valgas","year":"2019","unstructured":"Valgas P, da Silva C, Hern\u00e1ndez-Saavedra D, White JD, Stanford KI (2019) Cold and exercise: therapeutic tools to activate brown adipose tissue and combat obesity. Biology 8(1):9","journal-title":"Biology"},{"issue":"2","key":"73_CR261","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1210\/jc.2010-1722","volume":"96","author":"NJ van der Zijl","year":"2011","unstructured":"van der Zijl NJ, Goossens GH, Moors CC, van Raalte DH, Muskiet MH, Pouwels PJ et al (2011) Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on \u03b2-cell function in individuals with impaired glucose metabolism. J Clin Endocrinol Metabol 96(2):459\u2013467","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"73_CR262","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1530\/JOE-17-0289","volume":"235","author":"MJ VandeKopple","year":"2017","unstructured":"VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A et al (2017) Stress-responsive HILPDA is necessary for thermoregulation during fasting. J Endocrinol 235(1):27\u201338","journal-title":"J Endocrinol"},{"issue":"5","key":"73_CR263","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1016\/j.cmet.2018.04.006","volume":"27","author":"F Villarroya","year":"2018","unstructured":"Villarroya F, Cereijo R, Villarroya J, Gavald\u00e0-Navarro A, Giralt M (2018) Toward an understanding of how immune cells control brown and beige adipobiology. Cell Metab 27(5):954\u2013961","journal-title":"Cell Metab"},{"issue":"9","key":"73_CR264","doi-asserted-by":"publisher","first-page":"2720","DOI":"10.2337\/diabetes.54.9.2720","volume":"54","author":"KA Virtanen","year":"2005","unstructured":"Virtanen KA, Iozzo P, H\u00e4llsten K, Huupponen R, Parkkola R, Janatuinen T et al (2005) Increased fat mass compensates for insulin resistance in abdominal obesity and type 2 diabetes, a positron\u2013emitting tomography study. Diabetes 54(9):2720\u20132726","journal-title":"Diabetes"},{"issue":"1","key":"73_CR265","first-page":"E19","volume":"302","author":"TB Wald\u00e9n","year":"2012","unstructured":"Wald\u00e9n TB, Hansen IR, Timmons JA, Cannon B, Nedergaard J (2012) Recruited vs. nonrecruited molecular signatures of brown, \u201cbrite,\u201d and white adipose tissues. Am J Physiol 302(1):E19\u2013E31","journal-title":"Am J Physiol"},{"issue":"11","key":"73_CR266","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrm.2016.96","volume":"17","author":"W Wang","year":"2016","unstructured":"Wang W, Seale P (2016) Control of brown and beige fat development. Nat Rev Mol Cell Biol 17(11):691\u2013702","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"73_CR267","doi-asserted-by":"publisher","first-page":"1765","DOI":"10.1007\/s00018-016-2420-x","volume":"74","author":"S Wang","year":"2017","unstructured":"Wang S, Yang X (2017) Inter-organ regulation of adipose tissue browning. Cell Mol Life Sci 74(10):1765\u20131776","journal-title":"Cell Mol Life Sci"},{"issue":"40","key":"73_CR268","doi-asserted-by":"publisher","first-page":"14466","DOI":"10.1073\/pnas.1412685111","volume":"111","author":"W Wang","year":"2014","unstructured":"Wang W, Kissig M, Rajakumari S, Huang L, Lim H-W, Won K-J et al (2014) Ebf2 is a selective marker of brown and beige adipogenic precursor cells. Proc Natl Acad Sci 111(40):14466\u201314471","journal-title":"Proc Natl Acad Sci"},{"key":"73_CR269","doi-asserted-by":"crossref","unstructured":"Wang Y-L, Lin S-P, Hsieh P, Hung S-C (2016) Concomitant beige adipocyte differentiation upon induction of mesenchymal stem cells into brown adipocytes. Biochem Biophys Res Commun 478","DOI":"10.1016\/j.bbrc.2016.08.008"},{"issue":"4","key":"73_CR270","doi-asserted-by":"publisher","first-page":"e44977","DOI":"10.15252\/embr.201744977","volume":"19","author":"B Wang","year":"2018","unstructured":"Wang B, Li A, Li X, Ho PWL, Wu D, Wang X et al (2018) Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. EMBO Rep 19(4):e44977. https:\/\/doi.org\/10.15252\/embr.201744977","journal-title":"EMBO Rep"},{"key":"73_CR271","doi-asserted-by":"crossref","unstructured":"White PJ, McGarrah RW, Herman MA, Bain JR, Shah SH, Newgard CB (2021) Insulin action, type 2 diabetes, and branched-chain amino acids: a two-way street. Mol Metab:101261","DOI":"10.1016\/j.molmet.2021.101261"},{"issue":"4","key":"73_CR272","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1016\/j.cell.2012.02.066","volume":"149","author":"J Whittle Andrew","year":"2012","unstructured":"Whittle Andrew J, Carobbio S, Martins L, Slawik M, Hondares E, V\u00e1zquez Mar\u00eda J et al (2012) BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions. Cell 149(4):871\u2013885. https:\/\/doi.org\/10.1016\/j.cell.2012.02.066","journal-title":"Cell"},{"issue":"1","key":"73_CR273","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12986-018-0291-x","volume":"15","author":"S Worsch","year":"2018","unstructured":"Worsch S, Heikenwalder M, Hauner H, Bader BL (2018) Dietary n-3 long-chain polyunsaturated fatty acids upregulate energy dissipating metabolic pathways conveying anti-obesogenic effects in mice. Nutr Metab 15(1):65","journal-title":"Nutr Metab"},{"issue":"2","key":"73_CR274","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.cell.2012.05.016","volume":"150","author":"J Wu","year":"2012","unstructured":"Wu J, Bostr\u00f6m P, Sparks Lauren M, Ye L, Choi Jang H, Giang A-H et al (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 150(2):366\u2013376","journal-title":"Cell"},{"issue":"29","key":"73_CR275","doi-asserted-by":"publisher","first-page":"10167","DOI":"10.1073\/pnas.0802486105","volume":"105","author":"Y Xue","year":"2008","unstructured":"Xue Y, Cao R, Nilsson D, Chen S, Westergren R, Hedlund E-M et al (2008) FOXC2 controls Ang-2 expression and modulates angiogenesis, vascular patterning, remodeling, and functions in adipose tissue. Proc Natl Acad Sci 105(29):10167\u201310172","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"73_CR276","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1038\/s41467-019-13914-8","volume":"11","author":"Y Yang","year":"2020","unstructured":"Yang Y, Fu M, Li M-D, Zhang K, Zhang B, Wang S et al (2020) O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity. Nat Commun 11(1):181","journal-title":"Nat Commun"},{"issue":"3","key":"73_CR277","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1530\/JOE-18-0289","volume":"239","author":"R Yasmeen","year":"2018","unstructured":"Yasmeen R, Shen Q, Lee A, Leung JH, Kowdley D, DiSilvestro DJ et al (2018) Epiregulin induces leptin secretion and energy expenditure in high-fat diet-fed mice. J Endocrinol 239(3):377\u2013388","journal-title":"J Endocrinol"},{"issue":"1","key":"73_CR278","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s11684-013-0262-6","volume":"7","author":"J Ye","year":"2013","unstructured":"Ye J (2013) Mechanisms of insulin resistance in obesity. Front Med 7(1):14\u201324","journal-title":"Front Med"},{"issue":"Suppl 42","key":"73_CR279","first-page":"39","volume":"95","author":"H Yki-J\u00e4rvinen","year":"2002","unstructured":"Yki-J\u00e4rvinen H (2002) Ectopic fat accumulation: an important cause of insulin resistance in humans. J R Soc Med 95(Suppl 42):39\u201345","journal-title":"J R Soc Med"},{"issue":"7771","key":"73_CR280","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/s41586-019-1503-x","volume":"572","author":"T Yoneshiro","year":"2019","unstructured":"Yoneshiro T, Wang Q, Tajima K, Matsushita M, Maki H, Igarashi K et al (2019) BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. Nature 572(7771):614\u2013619","journal-title":"Nature"},{"key":"73_CR281","doi-asserted-by":"publisher","first-page":"e66865","DOI":"10.7554\/eLife.66865","volume":"10","author":"T Yoneshiro","year":"2021","unstructured":"Yoneshiro T, Kataoka N, Walejko JM, Ikeda K, Brown Z, Yoneshiro M et al (2021) Metabolic flexibility via mitochondrial BCAA carrier SLC25A44 is required for optimal fever. Elife 10:e66865","journal-title":"Elife"},{"issue":"7","key":"73_CR282","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00018-007-6359-9","volume":"64","author":"JF Youngren","year":"2007","unstructured":"Youngren JF (2007) Regulation of insulin receptor function. Cell Mol Life Sci 64(7):873","journal-title":"Cell Mol Life Sci"},{"issue":"6035","key":"73_CR283","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.1126\/science.1199484","volume":"332","author":"Y Yu","year":"2011","unstructured":"Yu Y, Yoon S-O, Poulogiannis G, Yang Q, Ma XM, Vill\u00e9n J et al (2011) Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 332(6035):1322\u20131326","journal-title":"Science"},{"issue":"1","key":"73_CR284","doi-asserted-by":"publisher","first-page":"5323","DOI":"10.1038\/s41467-021-25674-5","volume":"12","author":"F Yu","year":"2021","unstructured":"Yu F, Wang Z, Zhang T, Chen X, Xu H, Wang F et al (2021) Deficiency of intestinal Bmal1 prevents obesity induced by high-fat feeding. Nat Commun 12(1):5323","journal-title":"Nat Commun"},{"issue":"51","key":"73_CR285","doi-asserted-by":"publisher","first-page":"35375","DOI":"10.1074\/jbc.M806480200","volume":"283","author":"J Zhang","year":"2008","unstructured":"Zhang J, Gao Z, Yin J, Quon MJ, Ye J (2008) S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-\u03b1 signaling through IKK2. J Biol Chem 283(51):35375\u201335382","journal-title":"J Biol Chem"},{"key":"73_CR286","doi-asserted-by":"publisher","first-page":"e00170","DOI":"10.7554\/eLife.00170","volume":"2","author":"H Zhou","year":"2013","unstructured":"Zhou H, Kaplan T, Li Y, Grubisic I, Zhang Z, Wang PJ et al (2013) Dual functions of TAF7L in adipocyte differentiation. Elife 2:e00170","journal-title":"Elife"},{"key":"73_CR287","doi-asserted-by":"publisher","first-page":"e02811","DOI":"10.7554\/eLife.02811","volume":"3","author":"H Zhou","year":"2014","unstructured":"Zhou H, Wan B, Grubisic I, Kaplan T, Tjian R (2014) TAF7L modulates brown adipose tissue formation. Elife 3:e02811","journal-title":"Elife"},{"issue":"3","key":"73_CR288","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.cmet.2016.08.005","volume":"24","author":"Y Zhu","year":"2016","unstructured":"Zhu Y, Gao Y, Tao C, Shao M, Zhao S, Huang W et al (2016) Connexin 43 mediates White adipose tissue beiging by facilitating the propagation of sympathetic neuronal signals. Cell Metab 24(3):420\u2013433","journal-title":"Cell Metab"},{"issue":"1","key":"73_CR289","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.cmet.2017.12.002","volume":"27","author":"RK Zwick","year":"2018","unstructured":"Zwick RK, Guerrero-Juarez CF, Horsley V, Plikus MV (2018) Anatomical, physiological, and functional diversity of adipose tissue. Cell Metab 27(1):68\u201383","journal-title":"Cell Metab"}],"container-title":["Reviews of Physiology, Biochemistry and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/112_2022_73","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T03:03:40Z","timestamp":1674961420000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/112_2022_73"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"ISBN":["9783031256271","9783031256288"],"references-count":289,"URL":"https:\/\/doi.org\/10.1007\/112_2022_73","relation":{},"ISSN":["0303-4240","1617-5786"],"issn-type":[{"value":"0303-4240","type":"print"},{"value":"1617-5786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"2 August 2022","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}},{"value":"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be constructed as a potential conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"BS and NCB conceived the idea. BS, OT, and the US prepared the first draft and figures. All authors critically discussed and edited the manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Author Contributions"}},{"value":"Data sharing does not apply to this article as no new data were created or analyzed in this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Data Availability Statement"}},{"value":"This work was supported by the Council of Scientific and Industrial Research (CSIR), India (file no.09\/1035 (0011)\/2017-EMR-I to BS for Junior Research Fellowship), the Science and Engineering Research Board (SERB), DST, India (Grant number ECR\/2016\/001247 to NCB), and DBT, India (Grant number BT\/RLF\/Re-entry\/41\/2014 and BT\/PR28935\/MED\/30\/2035\/2018).","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}}]}}