{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:37:25Z","timestamp":1774417045033,"version":"3.50.1"},"publisher-location":"Berlin, Heidelberg","reference-count":32,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540281757","type":"print"},{"value":"9783540318750","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005]]},"DOI":"10.1007\/11536444_10","type":"book-chapter","created":{"date-parts":[[2010,7,21]],"date-time":"2010-07-21T19:51:56Z","timestamp":1279741916000},"page":"126-138","source":"Crossref","is-referenced-by-count":30,"title":["Inspiration for the Next Generation of Artificial Immune Systems"],"prefix":"10.1007","author":[{"given":"Paul S.","family":"Andrews","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jon","family":"Timmis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"10_CR1","volume-title":"Artificial Immune Systems: A New Computational Intelligence Approach","author":"L.N. Castro de","year":"2002","unstructured":"de Castro, L.N., Timmis, J.: Artificial Immune Systems: A New Computational Intelligence Approach. Springer, Heidelberg (2002)"},{"key":"10_CR2","doi-asserted-by":"crossref","unstructured":"Timmis, J., Bentley, P.J. (eds.): Proceedings of the 1st International Conference on Artificial Immune Systems (ICARIS 2002), University of Kent Printing Unit (2002)","DOI":"10.1007\/b12020"},{"key":"10_CR3","doi-asserted-by":"crossref","unstructured":"Timmis, J., Bentley, P., Hart, E. (eds.): Proceedings of the 2nd International Conference on Artificial Immune Systems (ICARIS 2003). Springer, Heidelberg (2003)","DOI":"10.1007\/b12020"},{"key":"10_CR4","volume-title":"Proceedings of the 3rd international Conference on Artificial Immune Systems (ICARIS 2004)","year":"2004","unstructured":"Nicosia, G., Cutello, V., Bentley, P.J., Timmis, J. (eds.): Proceedings of the 3rd international Conference on Artificial Immune Systems (ICARIS 2004). Springer, Heidelberg (2004)"},{"key":"10_CR5","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1007\/978-3-540-45192-1_22","volume-title":"Artificial Immune Systems","author":"A. Freitas","year":"2003","unstructured":"Freitas, A., Timmis, J.: Revisiting the foundations of artificial immune systems: A problem oriented perspective. In: Timmis, J., Bentley, P.J., Hart, E. (eds.) ICARIS 2003. LNCS, vol.\u00a02787, pp. 229\u2013241. Springer, Heidelberg (2003)"},{"key":"10_CR6","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/978-3-540-30220-9_5","volume-title":"Artificial Immune Systems","author":"S. Stepney","year":"2004","unstructured":"Stepney, S., Smith, R.E., Timmis, J., Tyrell, A.M.: Towards a conceptual framework for artificial immune systems. In: Nicosia, G., Cutello, V., Bentley, P.J., Timmis, J. (eds.) ICARIS 2004. LNCS, vol.\u00a03239, pp. 53\u201364. Springer, Heidelberg (2004)"},{"key":"10_CR7","volume-title":"Tending Adam\u2019s Garden: Evolving the Cognitive Immune Self","author":"I.R. Cohen","year":"2000","unstructured":"Cohen, I.R.: Tending Adam\u2019s Garden: Evolving the Cognitive Immune Self. Elsevier Academic Press, Amsterdam (2000)"},{"key":"10_CR8","doi-asserted-by":"crossref","DOI":"10.5962\/bhl.title.8281","volume-title":"The Clonal Selection Theory of Acquired Immunity","author":"F.M. Burnet","year":"1959","unstructured":"Burnet, F.M.: The Clonal Selection Theory of Acquired Immunity. Cambridge University Press, Cambridge (1959)"},{"key":"10_CR9","first-page":"373","volume":"125C","author":"N.K. Jerne","year":"1974","unstructured":"Jerne, N.K.: Towards a network theory of the immune system. Ann. Immunol (Inst. Pasteur)\u00a0125C, 373\u2013389 (1974)","journal-title":"Ann. Immunol. (Inst. Pasteur)"},{"key":"10_CR10","first-page":"217","volume-title":"Proceedings of the 1st European Conference on Artificial Life (ECAL)","author":"H. Bersini","year":"1991","unstructured":"Bersini, H.: Immune network and adaptive control. In: Proceedings of the 1st European Conference on Artificial Life (ECAL), pp. 217\u2013226. MIT Press, Cambridge (1991)"},{"key":"10_CR11","doi-asserted-by":"crossref","unstructured":"Forrest, S., Perelson, A., Allen, L., Cherukuri, R.: Self\u2013nonself discrimination in a computer. In: Proceedings of the IEEE Symposium on Research Security and Privacy, pp. 202\u2013212 (1994)","DOI":"10.1109\/RISP.1994.296580"},{"key":"10_CR12","first-page":"344","volume-title":"Proceedings of the 6th International Conference on Genetic Algorithms","author":"R.R. Hightower","year":"1995","unstructured":"Hightower, R.R., Forrest, S.A., Perelson, A.S.: The evolution of emergent organization in immune system gene libraries. In: Proceedings of the 6th International Conference on Genetic Algorithms, pp. 344\u2013350. Morgan Kaufmann, San Francisco (1995)"},{"key":"10_CR13","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1007\/978-3-540-30220-9_33","volume-title":"Artificial Immune Systems","author":"E. Hart","year":"2004","unstructured":"Hart, E., Ross, P.: Studies on the implications of shape-space models for idiotypic networks. In: Nicosia, G., Cutello, V., Bentley, P.J., Timmis, J. (eds.) ICARIS 2004. LNCS, vol.\u00a03239, pp. 413\u2013426. Springer, Heidelberg (2004)"},{"key":"10_CR14","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/978-3-540-30220-9_31","volume-title":"Artificial Immune Systems","author":"W.O. Wilson","year":"2004","unstructured":"Wilson, W.O., Garrett, S.M.: Modelling immune memory for prediction and computation. In: Nicosia, G., Cutello, V., Bentley, P.J., Timmis, J. (eds.) ICARIS 2004. LNCS, vol.\u00a03239, pp. 386\u2013399. Springer, Heidelberg (2004)"},{"key":"10_CR15","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/978-3-540-30220-9_32","volume-title":"Artificial Immune Systems","author":"C. Jacob","year":"2004","unstructured":"Jacob, C., Litorco, J., Lee, L.: Immunity through swarms: Agent-based simulations of the human immune system. In: Nicosia, G., Cutello, V., Bentley, P.J., Timmis, J. (eds.) ICARIS 2004. LNCS, vol.\u00a03239, pp. 400\u2013412. Springer, Heidelberg (2004)"},{"key":"10_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1006\/smim.2000.0260","volume":"12","author":"C.C. Anderson","year":"2000","unstructured":"Anderson, C.C., Matzinger, P.: Danger: the view from the bottom of the cliff. Seminars in Immunology\u00a012, 231\u2013238 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR17","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1006\/smim.2000.0235","volume":"12","author":"P. Bretscher","year":"2000","unstructured":"Bretscher, P.: Contemporary models for peripheral tolerance and the classical \u2018historical postulate\u2019. Seminars in Immunology\u00a012, 221\u2013229 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR18","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1006\/smim.2000.0234","volume":"12","author":"I.R. Cohen","year":"2000","unstructured":"Cohen, I.R.: Discrimination and dialogue in the immune system. Seminars in Immunology\u00a012, 215\u2013219 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1006\/smim.2000.0232","volume":"12","author":"Z. Grossman","year":"2000","unstructured":"Grossman, Z., Paul, W.E.: Self-tolerance: context dependent tuning of t cell antigen recognition. Seminars in Immunology\u00a012, 197\u2013203 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR20","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1006\/smim.2000.0231","volume":"12","author":"R.E. Langman","year":"2000","unstructured":"Langman, R.E., Cohn, M.: A minimal model for the self\u2013nonself discrimination: a return to basics. Seminars in Immunology\u00a012, 189\u2013195 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR21","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1006\/smim.2000.0230","volume":"12","author":"R. Medzhitov","year":"2000","unstructured":"Medzhitov, R., Janeway, C.A.: How does the immune system distinguish self from nonself? Seminars in Immunology\u00a012, 185\u2013188 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR22","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1006\/smim.2000.0237","volume":"12","author":"A.I. Tauber","year":"2000","unstructured":"Tauber, A.I.: Moving beyond the immune self? Seminars in Immunology\u00a012, 241\u2013248 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR23","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1006\/smim.2000.0252","volume":"12","author":"R.E. Langman","year":"2000","unstructured":"Langman, R.E., Cohn, M.: Editorial summary. Seminars in Immunology\u00a012, 343\u2013344 (2000)","journal-title":"Seminars in Immunology"},{"key":"10_CR24","first-page":"151","volume-title":"Design Principles for Immune Systems and Other Distributed Autonomous Systems","author":"I.R. Cohen","year":"2001","unstructured":"Cohen, I.R.: The creation of immune specificity. In: Segal, L.A., Cohen, I.R. (eds.) Design Principles for Immune Systems and Other Distributed Autonomous Systems, pp. 151\u2013159. Oxford University Press, Oxford (2001)"},{"key":"10_CR25","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1103\/RevModPhys.69.1219","volume":"69","author":"A.S. Perelson","year":"1997","unstructured":"Perelson, A.S., Weisbuch, G.: Immunology for physicists. Reviews of Modern Physics\u00a069, 1219\u20131267 (1997)","journal-title":"Reviews of Modern Physics"},{"key":"10_CR26","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1109\/5992.852392","volume":"2","author":"S.H. Kleinstein","year":"2000","unstructured":"Kleinstein, S.H., Seiden, P.E.: Simulating the immune system. Computing in Science and Engineering\u00a02, 69\u201377 (2000)","journal-title":"Computing in Science and Engineering"},{"key":"10_CR27","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1088\/0305-4470\/21\/3\/013","volume":"21","author":"G. Weisbuch","year":"1988","unstructured":"Weisbuch, G., Atlan, H.: Control of the immune response. Journal of Physics A: Mathematical and General\u00a021, 189\u2013192 (1988)","journal-title":"Journal of Physics A: Mathematical and General"},{"key":"10_CR28","doi-asserted-by":"publisher","first-page":"2485","DOI":"10.1101\/gr.1215303","volume":"13","author":"S. Efroni","year":"2003","unstructured":"Efroni, S., Harel, D., Cohen, I.R.: Towards rigorous comprehension of biological complexity: Modeling, execution, and visualization of thymic t-cell maturation. Genome Research\u00a013, 2485\u20132497 (2003)","journal-title":"Genome Research"},{"key":"10_CR29","first-page":"189","volume-title":"1991 Lectures in Complex Systems","author":"C.G. Langton","year":"1992","unstructured":"Langton, C.G.: Artificial life. In: Nadel, L., Stein, D. (eds.) 1991 Lectures in Complex Systems, pp. 189\u2013241. Addison-Wesley, Reading (1992)"},{"key":"10_CR30","doi-asserted-by":"crossref","unstructured":"Johnson, C.G., Goldman, J.P., Gullick, W.J.: Simulating complex intracellular processes using object-oriented computational modelling. Progress in Biophysics and Molecular Biology\u00a086 (2004)","DOI":"10.1016\/j.pbiomolbio.2003.11.001"},{"key":"10_CR31","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jtbi.2003.12.011","volume":"228","author":"D.L. Chao","year":"2004","unstructured":"Chao, D.L., Davenport, M.P., Forrest, S., Perelson, A.S.: A stochastic model of cytotoxic t cell responses. Journal of Theoretical Biology\u00a0228, 227\u2013240 (2004)","journal-title":"Journal of Theoretical Biology"},{"key":"10_CR32","doi-asserted-by":"publisher","DOI":"10.4324\/9780203451519","volume-title":"An Introduction To Neural Networks","author":"K. Gurney","year":"1997","unstructured":"Gurney, K.: An Introduction To Neural Networks. Taylor & Francis, Abington (1997)"}],"container-title":["Lecture Notes in Computer Science","Artificial Immune Systems"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/11536444_10.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T06:07:20Z","timestamp":1740290840000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/11536444_10"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005]]},"ISBN":["9783540281757","9783540318750"],"references-count":32,"URL":"https:\/\/doi.org\/10.1007\/11536444_10","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005]]}}}