{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:19:25Z","timestamp":1767849565893,"version":"3.49.0"},"publisher-location":"Berlin, Heidelberg","reference-count":26,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540332954","type":"print"},{"value":"9783540332961","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/11732990_11","type":"book-chapter","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T12:59:27Z","timestamp":1143550767000},"page":"114-129","source":"Crossref","is-referenced-by-count":11,"title":["Detecting MicroRNA Targets by Linking Sequence, MicroRNA and Gene Expression Data"],"prefix":"10.1007","author":[{"given":"Jim C.","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quaid D.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan J.","family":"Frey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"11_CR1","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1038\/nature02871","volume":"431","author":"V. Ambros","year":"2004","unstructured":"Ambros, V.: The functions of animal microRNAs. Nature\u00a0431, 350\u2013355 (2004)","journal-title":"Nature"},{"key":"11_CR2","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1261\/rna.7119904","volume":"10","author":"T. Babak","year":"2004","unstructured":"Babak, T., Zhang, W., Morris, Q., Blencowe, B.J., Hughes, T.R.: Probing microRNAs with microarrays: Tissue specificity and functional inference. RNA\u00a010, 1813\u20131819 (2004)","journal-title":"RNA"},{"key":"11_CR3","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.cell.2005.07.031","volume":"122","author":"S. Bagga","year":"2005","unstructured":"Bagga, S., et al.: Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell\u00a0122, 553\u2013563 (2005)","journal-title":"Cell"},{"key":"11_CR4","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","volume":"116","author":"D.P. Bartel","year":"2004","unstructured":"Bartel, D.P.: MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell\u00a0116, 281\u2013297 (2004)","journal-title":"Cell"},{"key":"11_CR5","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1038\/ng1590","volume":"37","author":"I. Bentwich","year":"2005","unstructured":"Bentwich, I., et al.: Identification of hundreds of conserved and nonconserved human microRNAs. Nature Genetics\u00a037, 766\u2013770 (2005)","journal-title":"Nature Genetics"},{"issue":"1","key":"11_CR6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cell.2004.12.031","volume":"120","author":"E. Berezikov","year":"2005","unstructured":"Berezikov, E., et al.: Phylogenetic shadowing and computational identification of human microRNA genes. Cell\u00a0120(1), 21\u201324 (2005)","journal-title":"Cell"},{"key":"11_CR7","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1101\/gr.229202","volume":"4","author":"W.J. Kent","year":"2002","unstructured":"Kent, W.J.: BLAT \u2013 The BLAST-Like Alignment Tool. Genome Research\u00a04, 656\u2013664 (2002)","journal-title":"Genome Research"},{"key":"11_CR8","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1038\/35103511","volume":"2","author":"S. Eddy","year":"2001","unstructured":"Eddy, S.: Non-coding RNA genes and the modern RNA world. Nature Reviews Genetics\u00a02, 919\u2013929 (2001)","journal-title":"Nature Reviews Genetics"},{"key":"11_CR9","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1038\/ng1630","volume":"37","author":"B.J. Frey","year":"2005","unstructured":"Frey, B.J., et al.: Genome-wide analysis of mouse transcripts using exon-resolution microarrays and factor graphs. Nature Genetics\u00a037, 991\u2013996 (2005)","journal-title":"Nature Genetics"},{"key":"11_CR10","first-page":"422","volume-title":"Proceedings of the Pacific Symposium on Biocomputing 2001","author":"A. Hartemink","year":"2001","unstructured":"Hartemink, A., Gifford, D., Jaakkola, T., Young, R.: Using graphical models and genomic expression data to statistically validate models of genetic regulatory networks. In: Proceedings of the Pacific Symposium on Biocomputing 2001, pp. 422\u2013433. World Scientific, New Jersey (2001)"},{"key":"11_CR11","doi-asserted-by":"crossref","unstructured":"Huang, J.C., Morris, Q.D., Hughes, T.R., Frey, B.J.: GenXHC: A probabilistic generative model for cross-hybridization compensation in high-density, genome-wide microarray data. In: Proceedings of the Thirteenth Annual Conference on Intelligent Systems for Molecular Biology, June 25-29 (2005)","DOI":"10.1093\/bioinformatics\/bti1045"},{"key":"11_CR12","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/86730","volume":"19","author":"T.R. Hughes","year":"2001","unstructured":"Hughes, T.R., et al.: Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer. Nature Biotechnol.\u00a019, 342\u2013347 (2001)","journal-title":"Nature Biotechnol."},{"key":"11_CR13","doi-asserted-by":"crossref","unstructured":"John, B., et al.: Human MicroRNA targets. PLoS Biol.\u00a02(11), e363 (2004)","DOI":"10.1371\/journal.pbio.0020363"},{"key":"11_CR14","series-title":"Learning in Graphical Models","volume-title":"An introduction to variational methods for graphical models","author":"M.I. Jordan","year":"1999","unstructured":"Jordan, M.I., Ghahramani, Z., Jaakkola, T.S., Saul, L.K.: An introduction to variational methods for graphical models. Learning in Graphical Models. MIT Press, Cambridge (1999)"},{"key":"11_CR15","unstructured":"Kislinger, T., et al.: Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Submitted to Cell (2005)"},{"key":"11_CR16","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1038\/ng1536","volume":"37","author":"A. Krek","year":"2005","unstructured":"Krek, A., et al.: Combinatorial microRNA target predictions. Nature Genetics\u00a037, 495\u2013500 (2005)","journal-title":"Nature Genetics"},{"key":"11_CR17","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","volume":"120","author":"B.P. Lewis","year":"2005","unstructured":"Lewis, B.P., Burge, C.B., Bartel, D.P.: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell\u00a0120, 15\u201320 (2005)","journal-title":"Cell"},{"key":"11_CR18","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/S0092-8674(03)01018-3","volume":"115","author":"B.P. Lewis","year":"2003","unstructured":"Lewis, B.P., et al.: Prediction of mammalian microRNA targets. Cell\u00a0115, 787\u2013798 (2003)","journal-title":"Cell"},{"key":"11_CR19","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1101\/gad.1074403","volume":"17","author":"L.P. Lim","year":"2003","unstructured":"Lim, L.P., et al.: The microRNAs of Caenorhabditis elegans. Genes Dev.\u00a017, 991\u20131008 (2003)","journal-title":"Genes Dev."},{"key":"11_CR20","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1038\/nature03315","volume":"433","author":"L.P. Lim","year":"2005","unstructured":"Lim, L.P., et al.: Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature\u00a0433, 769\u2013773 (2005)","journal-title":"Nature"},{"key":"11_CR21","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1038\/nbt1296-1675","volume":"14","author":"M. Lockhart","year":"1996","unstructured":"Lockhart, M., et al.: Expression monitoring by hybridization to high-density oligonucleotide arrays. Nature Biotechnol.\u00a014, 1675\u20131680 (1996)","journal-title":"Nature Biotechnol."},{"key":"11_CR22","series-title":"Learning in Graphical Models","volume-title":"A view of the EM algorithm that justifies incremental, sparse, and other variants","author":"R.M. Neal","year":"1998","unstructured":"Neal, R.M., Hinton, G.E.: A view of the EM algorithm that justifies incremental, sparse, and other variants. Learning in Graphical Models. Kluwer Academic Publishers, Dordrecht (1998)"},{"key":"11_CR23","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/nature03441","volume":"434","author":"X Xie","year":"2005","unstructured":"Xie, X., et al.: Systematic discovery of regulatory motifs in human promoters and 3\u2019 UTRs by comparison of several mammals. Nature\u00a0434, 338\u2013345 (2005)","journal-title":"Nature"},{"key":"11_CR24","doi-asserted-by":"crossref","unstructured":"Zilberstein, C.B.Z., Ziv-Ukelson, M., Pinter, R.Y., Yakhini, Z.: A high-throughput approach for associating microRNAs with their activity conditions. In: Proceedings of the Ninth Annual Conference on Research in Computational Molecular Biology, May 14-18 (2005)","DOI":"10.1007\/11415770_11"},{"key":"11_CR25","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/jbiol16","volume":"3","author":"W. Zhang","year":"2004","unstructured":"Zhang, W., Morris, Q., et al.: The functional landscape of mouse gene expression. J. Biol.\u00a03, 21\u201343 (2004)","journal-title":"J. Biol."},{"key":"11_CR26","unstructured":"Supplemental Data for Lewis et al. Cell 120, 15-20, \n                  \n                    http:\/\/web.wi.mit.edu\/bartel\/pub\/Supplemental%20Material\/Lewis%20et%20al%202005%20Supp\/"}],"container-title":["Lecture Notes in Computer Science","Research in Computational Molecular Biology"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/11732990_11.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T06:52:39Z","timestamp":1619506359000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/11732990_11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9783540332954","9783540332961"],"references-count":26,"URL":"https:\/\/doi.org\/10.1007\/11732990_11","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}