{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:48:24Z","timestamp":1768344504660,"version":"3.49.0"},"publisher-location":"Berlin, Heidelberg","reference-count":45,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783540341611","type":"print"},{"value":"9783540341659","type":"electronic"}],"license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/11753681_4","type":"book-chapter","created":{"date-parts":[[2006,7,28]],"date-time":"2006-07-28T06:31:54Z","timestamp":1154068314000},"page":"38-54","source":"Crossref","is-referenced-by-count":5,"title":["Towards Practical Biomolecular Computers Using Microfluidic Deoxyribozyme Logic Gate Networks"],"prefix":"10.1007","author":[{"given":"Joseph","family":"Farfel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darko","family":"Stefanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"4_CR1","doi-asserted-by":"publisher","first-page":"3555","DOI":"10.1021\/ja016756v","volume":"124","author":"M.N. Stojanovic","year":"2002","unstructured":"Stojanovic, M.N., Mitchell, T.E., Stefanovic, D.: Deoxyribozyme-based logic gates. Journal of the American Chemical Society\u00a0124, 3555\u20133561 (2002)","journal-title":"Journal of the American Chemical Society"},{"key":"4_CR2","doi-asserted-by":"publisher","first-page":"6673","DOI":"10.1021\/ja0296632","volume":"125","author":"M.N. Stojanovic","year":"2003","unstructured":"Stojanovic, M.N., Stefanovic, D.: Deoxyribozyme-based half adder. Journal of the American Chemical Society\u00a0125, 6673\u20136676 (2003)","journal-title":"Journal of the American Chemical Society"},{"key":"4_CR3","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/nbt862","volume":"21","author":"M.N. Stojanovic","year":"2003","unstructured":"Stojanovic, M.N., Stefanovic, D.: A deoxyribozyme-based molecular automaton. Nature Biotechnology\u00a021, 1069\u20131074 (2003)","journal-title":"Nature Biotechnology"},{"key":"4_CR4","doi-asserted-by":"publisher","first-page":"6914","DOI":"10.1021\/ja043003a","volume":"127","author":"M.N. Stojanovic","year":"2005","unstructured":"Stojanovic, M.N., Semova, S., Kolpashchikov, D., int Morgan, C., Stefanovic, D.: Deoxyribozyme-based ligase logic gates and their initial circuits. Journal of the American Chemical Society\u00a0127, 6914\u20136915 (2005)","journal-title":"Journal of the American Chemical Society"},{"key":"4_CR5","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1007\/11493785_22","volume-title":"DNA Computing","author":"C. Morgan","year":"2005","unstructured":"Morgan, C., Stefanovic, D., Moore, C., Stojanovic, M.N.: Building the components for a biomolecular computer. In: Ferretti, C., Mauri, G., Zandron, C. (eds.) DNA 2004. LNCS, vol.\u00a03384, pp. 247\u2013257. Springer, Heidelberg (2005)"},{"key":"4_CR6","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1023\/A:1012412916446","volume":"3","author":"H.-P. Chou","year":"2001","unstructured":"Chou, H.-P., Unger, M.A., Quake, S.R.: A microfabricated rotary pump. Biomedical Microdevices\u00a03, 323\u2013330 (2001)","journal-title":"Biomedical Microdevices"},{"key":"4_CR7","first-page":"580","volume":"298","author":"M.A. Unger","year":"2000","unstructured":"Unger, M.A., Chou, H.P., Thorsen, T., Scherer, A., Quake, S.R.: Monolithic microfabricated valves and pumps by multilayer soft lithography. Science\u00a0298, 580\u2013584 (2000)","journal-title":"Science"},{"key":"4_CR8","volume-title":"The Mathematics of Diffusion","author":"J. Crank","year":"1975","unstructured":"Crank, J.: The Mathematics of Diffusion, 2nd edn. Oxford University Press, Oxford (1975)","edition":"2"},{"key":"4_CR9","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/978-3-540-24628-2_17","volume-title":"DNA Computing","author":"M.S. Livstone","year":"2004","unstructured":"Livstone, M.S., Landweber, L.F.: Mathematical considerations in the design of microreactor-based DNA computers. In: Chen, J., Reif, J.H. (eds.) DAN 2003. LNCS, vol.\u00a02943, pp. 180\u2013189. Springer, Heidelberg (2004)"},{"key":"4_CR10","doi-asserted-by":"crossref","unstructured":"Gehani, A., Reif, J.: Micro-flow bio-molecular computation. BioSystems\u00a052 (1999)","DOI":"10.1016\/S0303-2647(99)00048-9"},{"key":"4_CR11","doi-asserted-by":"crossref","unstructured":"Ledesma, L., Manrique, D., Rodr\u00edguez-Pat\u00f3n, A., Silva, A.: A tissue P system and a DNA microfluidic device for solving the shortest common superstring problem (2004)","DOI":"10.1007\/s00500-004-0423-2"},{"key":"4_CR12","series-title":"Lecture Notes in Computer Science","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/3-540-48017-X_4","volume-title":"DNA Computing","author":"D. Noort van","year":"2002","unstructured":"van Noort, D., Gast, F.U., McCaskill, J.S.: DNA computing in microreactors. In: Jonoska, N., Seeman, N.C. (eds.) DNA 2001. LNCS, vol.\u00a02340, p. 33. Springer, Heidelberg (2002)"},{"key":"4_CR13","doi-asserted-by":"crossref","unstructured":"Wagler, P., van Noort, D., McCaskill, J.S.: Dna computing in microreactors. In: Proceedings of SPIE, vol.\u00a04590, pp. 6\u201313 (2001)","DOI":"10.1117\/12.454623"},{"key":"4_CR14","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1088\/0964-1726\/11\/5\/320","volume":"11","author":"D. Noort van","year":"2004","unstructured":"van Noort, D., Wagler, P., McCaskill, J.S.: Hybrid poly(dimethylsoloxane)-silicon microreactors used for molecular computing. Smart Materials and Structures\u00a011, 756\u2013760 (2004)","journal-title":"Smart Materials and Structures"},{"key":"4_CR15","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1007\/s11047-004-2667-2","volume":"3","author":"D. Noort van","year":"2004","unstructured":"van Noort, D., McCaskill, J.S.: Flows in micro fluidic networks: From theory to experiment. Natural Computing\u00a03, 395\u2013410 (2004)","journal-title":"Natural Computing"},{"key":"4_CR16","doi-asserted-by":"publisher","first-page":"2961","DOI":"10.1073\/pnas.061014198","volume":"98","author":"D.T. Chiu","year":"2001","unstructured":"Chiu, D.T., Pezzoli, E., Wu, H., Stroock, A.D., Whitesides, G.M.: Using three-dimensional microfluidic networks for solving computationally hard problems. Proceedings of the National Academy of Sciences of the USA\u00a098, 2961\u20132966 (2001)","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"4_CR17","doi-asserted-by":"publisher","first-page":"4714","DOI":"10.1021\/la030054x","volume":"19","author":"M.J. Fuerstman","year":"2003","unstructured":"Fuerstman, M.J., Deschatelets, P., Kane, R., Schwartz, A., Kenis, P.J.A., Deutsch, J.M., Whitesides, G.M.: Solving mazes using microfluidic networks. Langmuir\u00a019, 4714\u20134722 (2003)","journal-title":"Langmuir"},{"key":"4_CR18","doi-asserted-by":"publisher","first-page":"5074","DOI":"10.1063\/1.1764592","volume":"84","author":"T. Vestad","year":"2004","unstructured":"Vestad, T., Marr, D.W.M., Munakata, T.: Flow resistance for microfluidic logic operations. Applied Physics Letters\u00a084, 5074\u20135075 (2004)","journal-title":"Applied Physics Letters"},{"key":"4_CR19","volume-title":"Fluidics: Components and circuits","year":"1970","unstructured":"Foster, K., Parker, G.A. (eds.): Fluidics: Components and circuits. Wiley-Interscience, London and New York (1970)"},{"key":"4_CR20","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1126\/science.1076996","volume":"298","author":"T. Thorsen","year":"2002","unstructured":"Thorsen, T., Maerkl, S.J., Quake, S.R.: Microfluidic large-scale integration. Science\u00a0298, 580\u2013584 (2002)","journal-title":"Science"},{"key":"4_CR21","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1126\/science.1083694","volume":"300","author":"A. Groisman","year":"2003","unstructured":"Groisman, A., Enzelberger, M., Quake, S.R.: Microfluidic memory and control devices. Science\u00a0300, 955\u2013958 (2003)","journal-title":"Science"},{"key":"4_CR22","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/nbt871","volume":"21","author":"J.W. Hong","year":"2003","unstructured":"Hong, J.W., Quake, S.R.: Integrated nanoliter systems. Nature Biotechnology\u00a021, 1179\u20131183 (2003)","journal-title":"Nature Biotechnology"},{"key":"4_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1039\/B307628H","volume":"3","author":"P. Paik","year":"2003","unstructured":"Paik, P., Pamula, V.K., Fair, R.B.: Rapid droplet mixers for digital microfluidic systems. Lab on a Chip\u00a03, 253\u2013259 (2003)","journal-title":"Lab on a Chip"},{"key":"4_CR24","doi-asserted-by":"publisher","first-page":"9127","DOI":"10.1021\/la030090w","volume":"19","author":"J.D. Tice","year":"2003","unstructured":"Tice, J.D., Song, H., Lyon, A.D., Ismagilov, R.F.: Formation of droplets and mixing in multiphase microfluidics at low values of the Reynolds and the capillary numbers. Langmuir\u00a019, 9127\u20139133 (2003)","journal-title":"Langmuir"},{"key":"4_CR25","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/anie.200390203","volume":"42","author":"H. Song","year":"2003","unstructured":"Song, H., Tice, J.D., Ismagilov, R.F.: A microfluidic system for controlling reaction networks in time. Angewandte Chemie International Edition\u00a042, 768\u2013772 (2003)","journal-title":"Angewandte Chemie International Edition"},{"key":"4_CR26","doi-asserted-by":"publisher","first-page":"6327","DOI":"10.1021\/ja031689l","volume":"126","author":"C.J. Gerdts","year":"2004","unstructured":"Gerdts, C.J., Sharoyan, D.E., Ismagilov, R.F.: A synthetic reaction network: Chemical amplification using nonequilibrium autocatalytic reactions coupled in time. Journal of the American Chemical Society\u00a0126, 6327\u20136331 (2004)","journal-title":"Journal of the American Chemical Society"},{"key":"4_CR27","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/nbt871","volume":"21","author":"S. Wiggins","year":"2003","unstructured":"Wiggins, S.: Integrated nanoliter systems. Nature Biotechnology\u00a021, 1179\u20131183 (2003)","journal-title":"Nature Biotechnology"},{"key":"4_CR28","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature01993","volume":"425","author":"T.H. Solomon","year":"2003","unstructured":"Solomon, T.H., Mezi\u0107, I.: Uniform resonant chaotic mixing in fluid flows. Nature\u00a0425, 376\u2013380 (2003)","journal-title":"Nature"},{"key":"4_CR29","doi-asserted-by":"publisher","first-page":"8311","DOI":"10.1021\/la000600b","volume":"16","author":"N.L. Jeon","year":"2000","unstructured":"Jeon, N.L., Dertinger, S.K.W., Chiu, D.T., Choi, I.S., Stroock, A.D., Whitesides, G.M.: Generation of solution and surface gradients using microfluidic systems. Langmuir\u00a016, 8311\u20138316 (2000)","journal-title":"Langmuir"},{"key":"4_CR30","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1021\/ac001132d","volume":"73","author":"S.K.W. Dertinger","year":"2001","unstructured":"Dertinger, S.K.W., Chiu, D.T., Jeon, N.L., Whitesides, G.M.: Generation of gradients having complex shapes using microfluidic networks. Analytical Chemistry\u00a073, 1240\u20131246 (2001)","journal-title":"Analytical Chemistry"},{"key":"4_CR31","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/nbt712","volume":"20","author":"N.L. Jeon","year":"2002","unstructured":"Jeon, N.L., Bakaran, H., Dertinger, S.K.W., Whitesides, G.M., Van De Water, L., Toner, M.: Neutrophil chemotaxis in linear and complex gradients of interleukin-8 formed in a microfabricated device. Nature Biotechnology\u00a020, 826\u2013830 (2002)","journal-title":"Nature Biotechnology"},{"key":"4_CR32","doi-asserted-by":"publisher","first-page":"8649","DOI":"10.1021\/ja00780a001","volume":"94","author":"R.J. Field","year":"1972","unstructured":"Field, R.J., K\u00f6r\u00f6s, E., Noyes, R.: Oscillations in chemical systems. II. Thorough analysis of temporal oscillation in the bromate-cerium-malonic acid system. Journal of the American Chemical Society\u00a094, 8649\u20138664 (1972)","journal-title":"Journal of the American Chemical Society"},{"key":"4_CR33","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1021\/ja00759a080","volume":"94","author":"R. Noyes","year":"1972","unstructured":"Noyes, R., Field, R.J., K\u00f6r\u00f6s, E.: Oscillations in chemical systems. I. Detailed mechanism in a system showing temporal oscillations. Journal of the American Chemical Society\u00a094, 1394\u20131395 (1972)","journal-title":"Journal of the American Chemical Society"},{"key":"4_CR34","series-title":"Lecture Notes in Biomathematics","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-93046-1","volume-title":"The Belousov-Zhabotinskii Reaction","author":"J.J. Tyson","year":"1976","unstructured":"Tyson, J.J.: The Belousov-Zhabotinskii Reaction. Lecture Notes in Biomathematics, vol.\u00a010. Springer, Heidelberg (1976)"},{"key":"4_CR35","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195096705.001.0001","volume-title":"An Introduction to Nonlinear Chemical Dynamics","author":"I.R. Epstein","year":"1998","unstructured":"Epstein, I.R., Pojman, J.A.: An Introduction to Nonlinear Chemical Dynamics. Oxford University Press, New York (1998)"},{"key":"4_CR36","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1073\/pnas.89.1.388","volume":"89","author":"A. Hjelmfelt","year":"1992","unstructured":"Hjelmfelt, A., Ross, J.: Chemical implementation and thermodynamics of collective neural networks. Proceedings of the National Academy of Sciences of the USA\u00a089, 388\u2013391 (1992)","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"4_CR37","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1073\/pnas.91.1.63","volume":"91","author":"A. Hjelmfelt","year":"1994","unstructured":"Hjelmfelt, A., Ross, J.: Pattern recognition, chaos, and multiplicity in neural networks of excitable systems. Proceedings of the National Academy of Sciences of the USA\u00a091, 63\u201367 (1994)","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"4_CR38","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1126\/science.260.5106.335","volume":"260","author":"A. Hjelmfelt","year":"1993","unstructured":"Hjelmfelt, A., Schneider, F.W., Ross, J.: Pattern recognition in coupled chemical kinetic systems. Science\u00a0260, 335\u2013337 (1993)","journal-title":"Science"},{"key":"4_CR39","doi-asserted-by":"publisher","first-page":"10983","DOI":"10.1073\/pnas.88.24.10983","volume":"88","author":"A. Hjelmfelt","year":"1991","unstructured":"Hjelmfelt, A., Weinberger, E.D., Ross, J.: Chemical implementation of neural networks and Turing machines. Proceedings of the National Academy of Sciences of the USA\u00a088, 10983\u201310987 (1991)","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"4_CR40","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1073\/pnas.89.1.383","volume":"89","author":"A. Hjelmfelt","year":"1992","unstructured":"Hjelmfelt, A., Weinberger, E.D., Ross, J.: Chemical implementation of finite-state machines. Proceedings of the National Academy of Sciences of the USA\u00a089, 383\u2013387 (1992)","journal-title":"Proceedings of the National Academy of Sciences of the USA"},{"key":"4_CR41","doi-asserted-by":"publisher","first-page":"10063","DOI":"10.1021\/j100025a001","volume":"99","author":"J.-P. Laplante","year":"1995","unstructured":"Laplante, J.-P., Pemberton, M., Hjelmfelt, A., Ross, J.: Experiments on pattern recognition by chemical kinetics. The Journal of Physical Chemistry\u00a099, 10063\u201310065 (1995)","journal-title":"The Journal of Physical Chemistry"},{"key":"4_CR42","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/0022-5193(72)90108-7","volume":"36","author":"O.E. R\u00f6ssler","year":"1972","unstructured":"R\u00f6ssler, O.E.: A principle for chemical multivibration. Journal of Theoretical Biology\u00a036, 413\u2013417 (1972)","journal-title":"Journal of Theoretical Biology"},{"key":"4_CR43","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1515\/znb-1972-1202","volume":"27 b","author":"O.E. R\u00f6ssler","year":"1972","unstructured":"R\u00f6ssler, O.E., Seelig, F.F.: A Rashevsky-Turing system as a two-cellular flip-flop. Zeitschrift f\u00fcr Naturforschung\u00a027 b, 1444\u20131448 (1972)","journal-title":"Zeitschrift f\u00fcr Naturforschung"},{"key":"4_CR44","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1515\/znb-1972-1201","volume":"27 b","author":"F.F. Seelig","year":"1972","unstructured":"Seelig, F.F., R\u00f6ssler, O.E.: Model of a chemical reaction flip-flop with one unique switching input. Zeitschrift f\u00fcr Naturforschung\u00a027 b, 1441\u20131444 (1972)","journal-title":"Zeitschrift f\u00fcr Naturforschung"},{"key":"4_CR45","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1038\/35002125","volume":"403","author":"M.B. Elowitz","year":"2000","unstructured":"Elowitz, M.B., Leibler, S.: A synthetic oscillatory network of transcriptional regulators. Nature\u00a0403, 335\u2013338 (2000)","journal-title":"Nature"}],"container-title":["Lecture Notes in Computer Science","DNA Computing"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/11753681_4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T14:08:24Z","timestamp":1627654104000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/11753681_4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9783540341611","9783540341659"],"references-count":45,"URL":"https:\/\/doi.org\/10.1007\/11753681_4","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006]]}}}