{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T13:31:21Z","timestamp":1725543081817},"publisher-location":"Berlin, Heidelberg","reference-count":26,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"type":"print","value":"9783540365938"},{"type":"electronic","value":"9783540365952"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/11799511_16","type":"book-chapter","created":{"date-parts":[[2006,7,13]],"date-time":"2006-07-13T06:37:36Z","timestamp":1152772656000},"page":"185-194","source":"Crossref","is-referenced-by-count":10,"title":["Arevir: A Secure Platform for Designing Personalized Antiretroviral Therapies Against HIV"],"prefix":"10.1007","author":[{"given":"Kirsten","family":"Roomp","sequence":"first","affiliation":[]},{"given":"Niko","family":"Beerenwinkel","sequence":"additional","affiliation":[]},{"given":"Tobias","family":"Sing","sequence":"additional","affiliation":[]},{"given":"Eugen","family":"Sch\u00fclter","sequence":"additional","affiliation":[]},{"given":"Joachim","family":"B\u00fcch","sequence":"additional","affiliation":[]},{"given":"Saleta","family":"Sierra-Aragon","sequence":"additional","affiliation":[]},{"given":"Martin","family":"D\u00e4umer","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Hoffmann","sequence":"additional","affiliation":[]},{"given":"Rolf","family":"Kaiser","sequence":"additional","affiliation":[]},{"given":"Thomas","family":"Lengauer","sequence":"additional","affiliation":[]},{"given":"Joachim","family":"Selbig","sequence":"additional","affiliation":[]}],"member":"297","reference":[{"key":"16_CR1","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1177\/0897190005278612","volume":"18","author":"A. Stanic","year":"2005","unstructured":"Stanic, A., Schneider, T.K.: Overview of Antiretroviral Agents in 2005. Journal of Pharmacy Practice\u00a018, 228\u2013246 (2005)","journal-title":"Journal of Pharmacy Practice"},{"key":"16_CR2","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1742-4690-3-7","volume":"3","author":"A. Marcello","year":"2006","unstructured":"Marcello, A.: Latency: the hidden HIV-1 challenge. Retrovirology\u00a03, 7 (2006)","journal-title":"Retrovirology"},{"issue":"suppl. 1","key":"16_CR3","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1097\/00126334-200202011-00005","volume":"29","author":"W.G. Powderly","year":"2002","unstructured":"Powderly, W.G.: Long-term exposure to lifelong therapies. J. Acquir. Immune. Defic. Syndr. 29(suppl. 1), S28\u2013S40 (2002)","journal-title":"J. Acquir. Immune. Defic. Syndr."},{"key":"16_CR4","doi-asserted-by":"publisher","first-page":"1871","DOI":"10.1126\/science.280.5371.1871","volume":"280","author":"L. Perrin","year":"1998","unstructured":"Perrin, L., Telenti, A.: HIV treatment failure: testing for HIV resistance in clinical practice. Science\u00a0280, 1871\u20131873 (1998)","journal-title":"Science"},{"key":"16_CR5","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S1386-6532(99)00010-4","volume":"13","author":"H. Walter","year":"1999","unstructured":"Walter, H., Schmidt, B., Korn, K., Vandamme, A.M., Harrer, T., Uberla, K.: Rapid, phenotypic HIV-1 drug sensitivity assay for protease and reverse transcriptase inhibitors. J. Clin. Virol.\u00a013, 71\u201380 (1999)","journal-title":"J. Clin. Virol."},{"key":"16_CR6","first-page":"211","volume":"2","author":"R.W. Shafer","year":"2000","unstructured":"Shafer, R.W., Kantor, R.J., Gonzales, M.J.: The Genetic Basis of HIV-1 Resistance to Reverse Transcriptase and Protease Inhibitors. AIDS Rev.\u00a02, 211\u2013228 (2000)","journal-title":"AIDS Rev."},{"key":"16_CR7","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/135965350000500112","volume":"5","author":"V. Gruttola De","year":"2000","unstructured":"De Gruttola, V., Dix, L., D\u2019Aquila, R., Holder, D., Phillips, A., Ait-Khaled, M., Baxter, J., Clevenbergh, P., Hammer, S., Harrigan, R., Katzenstein, D., Lanier, R., Miller, M., Para, M., Yerly, S., Zolopa, A., Murray, J., Patick, A., Miller, V., Castillo, S., Pedneault, L., Mellors, J.: The relation between baseline HIV drug resistance and response to antiretroviral therapy: re-analysis of retrospective and prospective studies using a standardized data analysis plan. Antivir. Ther.\u00a05, 41\u201348 (2000)","journal-title":"Antivir. Ther."},{"key":"16_CR8","first-page":"52","volume":"5","author":"C. Kuiken","year":"2003","unstructured":"Kuiken, C., Korber, B., Shafer, R.W.: HIV sequence databases. AIDS Rev.\u00a05, 52\u201361 (2003)","journal-title":"AIDS Rev."},{"key":"16_CR9","unstructured":"Wang, D., Bloor, S., Larder, B.A.: The application of neural networks in predicting phenotypic resistance from genotypes for HIV-1 protease inhibitors. Antivir. Ther., 51\u201352 (2000)"},{"key":"16_CR10","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1086\/315673","volume":"182","author":"A.D. Sevin","year":"2000","unstructured":"Sevin, A.D., DeGruttola, V., Nijhuis, M., Schapiro, J.M., Foulkes, A.S., Para, M.F., Boucher, C.A.: Methods for investigation of the relationship between drug-susceptibility phenotype and human immunodeficiency virus type 1 genotype with applications to AIDS clinical trials group 333. J. Infect. Dis.\u00a0182, 59\u201367 (2000)","journal-title":"J. Infect. Dis."},{"key":"16_CR11","doi-asserted-by":"crossref","unstructured":"Beerenwinkel, N., Schmidt, B., Walter, H., Kaiser, R., Lengauer, T., Hoffmann, D., Korn, K., Selbig, J.: Geno2pheno: Interpreting Genotypic HIV Drug Resistance Tests. IEEE Intelligent Systems in Biology, 35\u201341 (2001)","DOI":"10.1109\/5254.972080"},{"key":"16_CR12","doi-asserted-by":"publisher","first-page":"8271","DOI":"10.1073\/pnas.112177799","volume":"99","author":"N. Beerenwinkel","year":"2002","unstructured":"Beerenwinkel, N., Schmidt, B., Walter, H., Kaiser, R., Lengauer, T., Hoffmann, D., Korn, K., Selbig, J.: Diversity and complexity of HIV-1 drug resistance: a bioinformatics approach to predicting phenotype from genotype. Proc. Natl. Acad. Sci. USA\u00a099, 8271\u20138276 (2002)","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"16_CR13","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1586\/14737159.6.2.207","volume":"6","author":"F. Cordes","year":"2006","unstructured":"Cordes, F., Kaiser, R., Selbig, J.: Bioinformatics approach to predicting HIV drug resistance. Expert Rev. Mol. Diagn.\u00a06, 207\u2013215 (2006)","journal-title":"Expert Rev. Mol. Diagn."},{"key":"16_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1386-5056(01)00127-7","volume":"62","author":"W.M. Tierney","year":"2001","unstructured":"Tierney, W.M.: Improving clinical decisions and outcomes with information: a review. Int. J. Med. Inform.\u00a062, 1\u20139 (2001)","journal-title":"Int. J. Med. Inform."},{"key":"16_CR15","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1001\/jama.284.14.1843","volume":"284","author":"W.W. Marshall","year":"2000","unstructured":"Marshall, W.W., Haley, R.W.: Use of a secure Internet Web site for collaborative medical re-search. Jama\u00a0284, 1843\u20131849 (2000)","journal-title":"Jama"},{"key":"16_CR16","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1136\/bmj.321.7270.1199","volume":"321","author":"R. Schoenberg","year":"2000","unstructured":"Schoenberg, R., Safran, C.: Internet based repository of medical records that retains patient confidentiality. Bmj\u00a0321, 1199\u20131203 (2000)","journal-title":"Bmj"},{"key":"16_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1136\/bmj.322.7281.283","volume":"322","author":"K.D. Mandl","year":"2001","unstructured":"Mandl, K.D., Szolovits, P., Kohane, I.S.: Public standards and patients\u2019 control: how to keep electronic medical records accessible but private. Bmj\u00a0322, 283\u2013287 (2001)","journal-title":"Bmj"},{"key":"16_CR18","doi-asserted-by":"crossref","unstructured":"Diffie, W., Hellman, M.: New directions in cryptography. IEEE Transactions on Information Theory, 472\u2013492 (1976)","DOI":"10.1109\/TIT.1976.1055638"},{"key":"16_CR19","doi-asserted-by":"crossref","unstructured":"Rivest, R.L., Shamir, A., Adleman, L.: A method for obtaining digital signatures and public-key cryptosystems. Communications of the ACM, 120\u2013126 (1978)","DOI":"10.1145\/359340.359342"},{"key":"16_CR20","unstructured":"Secure Hash Standard. FIPS PUB. Federal Information Processing Standards (1995)"},{"key":"16_CR21","doi-asserted-by":"publisher","first-page":"3850","DOI":"10.1093\/nar\/gkg575","volume":"31","author":"N. Beerenwinkel","year":"2003","unstructured":"Beerenwinkel, N., Daumer, M., Oette, M., Korn, K., Hoffmann, D., Kaiser, R., Lengauer, T., Selbig, J., Walter, H.: Geno2pheno: Estimating phenotypic drug resistance from HIV-1 genotypes. Nucleic Acids Res.\u00a031, 3850\u20133855 (2003)","journal-title":"Nucleic Acids Res."},{"key":"16_CR22","doi-asserted-by":"publisher","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","volume":"21","author":"T. Sing","year":"2005","unstructured":"Sing, T., Sander, O., Beerenwinkel, N., Lengauer, T.: ROCR: visualizing classifier performance in R. Bioinformatics\u00a021, 3940\u20133941 (2005)","journal-title":"Bioinformatics"},{"key":"16_CR23","doi-asserted-by":"publisher","first-page":"413","DOI":"10.2174\/138920305774329359","volume":"6","author":"S. Sirois","year":"2005","unstructured":"Sirois, S., Sing, T., Chou, K.C.: HIV-1 gp120 V3 loop for structure-based drug design. Curr. Protein Pept. Sci.\u00a06, 413\u2013422 (2005)","journal-title":"Curr. Protein Pept. Sci."},{"key":"16_CR24","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1093\/bioinformatics\/bti654","volume":"21","author":"N. Beerenwinkel","year":"2005","unstructured":"Beerenwinkel, N., Sing, T., Lengauer, T., Rahnenfuhrer, J., Roomp, K., Savenkov, I., Fischer, R., Hoffmann, D., Selbig, J., Korn, K., Walter, H., Berg, T., Braun, P., Fatkenheuer, G., Oette, M., Rockstroh, J., Kupfer, B., Kaiser, R., Daumer, M.: Computational methods for the design of effective therapies against drug resistant HIV strains. Bioinformatics\u00a021, 3943\u20133950 (2005)","journal-title":"Bioinformatics"},{"issue":"suppl.1","key":"16_CR25","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/bioinformatics\/btg1001","volume":"19","author":"N. Beerenwinkel","year":"2003","unstructured":"Beerenwinkel, N., Lengauer, T., Daumer, M., Kaiser, R., Walter, H., Korn, K., Hoffmann, D., Selbig, J.: Methods for optimizing antiviral combination therapies. Bioinformatics\u00a019(suppl.1), 16\u201325 (2003)","journal-title":"Bioinformatics"},{"key":"16_CR26","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1086\/430005","volume":"191","author":"N. Beerenwinkel","year":"2005","unstructured":"Beerenwinkel, N., Daumer, M., Sing, T., Rahnenfuhrer, J., Lengauer, T., Selbig, J., Hoffmann, D., Kaiser, R.: Estimating HIV evolutionary pathways and the genetic barrier to drug resistance. J. Infect. Dis.\u00a0191, 1953\u20131960 (2005)","journal-title":"J. Infect. Dis."}],"container-title":["Lecture Notes in Computer Science","Data Integration in the Life Sciences"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/11799511_16.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T01:37:26Z","timestamp":1683509846000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/11799511_16"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9783540365938","9783540365952"],"references-count":26,"URL":"https:\/\/doi.org\/10.1007\/11799511_16","relation":{},"ISSN":["0302-9743","1611-3349"],"issn-type":[{"type":"print","value":"0302-9743"},{"type":"electronic","value":"1611-3349"}],"subject":[],"published":{"date-parts":[[2006]]}}}