{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:46:03Z","timestamp":1790693163295,"version":"4.1.0"},"publisher-location":"Berlin, Heidelberg","reference-count":162,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642273452","type":"print"},{"value":"9783642273469","type":"electronic"}],"license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011]]},"DOI":"10.1007\/128_2011_269","type":"book-chapter","created":{"date-parts":[[2011,10,20]],"date-time":"2011-10-20T09:48:30Z","timestamp":1319104110000},"page":"83-111","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mammal Toxicology of Synthetic Pyrethroids"],"prefix":"10.1007","author":[{"given":"Ryozo","family":"Tsuji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoya","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,10,21]]},"reference":[{"key":"269_CR1_269","volume-title":"Pyrethrum flowers: production, chemistry, toxicology, and uses","author":"M Elliott","year":"1995","unstructured":"Elliott M (1995) Chemical in insect control. In: Casida JE, Quistad GE (eds) Pyrethrum flowers: production, chemistry, toxicology, and uses. Oxford University Press, New York"},{"key":"269_CR2_269","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1289\/ehp.8034189","volume":"34","author":"JE Casida","year":"1980","unstructured":"Casida JE (1980) Pyrethrum flowers and pyrethroid insecticides. Environ Health Perspect 34:189\u2013202","journal-title":"Environ Health Perspect"},{"key":"269_CR3_269","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/BF00293813","volume":"45","author":"RD Verschoyle","year":"1980","unstructured":"Verschoyle RD, Aldridge WN (1980) Structure-activity relationship of some pyrethroids in rats. Arch Toxicol 45:325\u2013329","journal-title":"Arch Toxicol"},{"key":"269_CR4_269","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0300-483X(01)00569-8","volume":"171","author":"DM Soderlund","year":"2002","unstructured":"Soderlund DM, Clark JM, Sheets LP (2002) Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicol 171:3\u201359","journal-title":"Toxicol"},{"key":"269_CR5_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (2002) Pesticide residues in food. Evaluations. Part II. Toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/2002pr04.htm. Accessed 15 Feb 2011"},{"key":"269_CR6_269","unstructured":"US Environmental Protection Agency (2009) Cyphenothrin. Human health assessment scoping document in support of registration review, EPA-HQ-OPP-2009-0842-0002. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2009-0842-0002. Accessed 15 Feb 2011"},{"key":"269_CR7_269","unstructured":"US Environmental Protection Agency (2009) RED (Reregistration Eligibility Decision) document, EPA-HQ-OPP-2006-0986-0017. http:\/\/www.epa.gov\/oppsrrd1\/REDs\/allethrins-amended-red.pdf. Accessed 14 Feb 2011"},{"key":"#cr-split#-269_CR8_269.1","unstructured":"US Environmental Protection Agency (1996) Pralle (Imiprothrin"},{"key":"#cr-split#-269_CR8_269.2","unstructured":"S-41311): Request for registration for non-food use - review of toxicity database http:\/\/www.epa.gov\/pesticides\/chemical\/foia\/cleared-reviews\/reviews\/004006\/004006-004.pdf Accessed 15 Feb 2011"},{"key":"269_CR9_269","first-page":"4","volume":"II","author":"N Matsuo","year":"2005","unstructured":"Matsuo N, Ujihara K, Shono Y et al (2005) Dicovery and development of a novel pyrethroid insecticide \u2018Metofluthrin (SumiOne, Eminence)\u2019. Sumitomo Chemical 2005-II:4\u201316","journal-title":"Sumitomo Chemical"},{"key":"269_CR10_269","unstructured":"International Programme on Chemical Safety (1990) Environmental Health Criteria 94. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc94.htm. Accessed 15 Feb 2011"},{"key":"269_CR11_269","unstructured":"International Programme on Chemical Safety (1990) Environmental Health Criteria 96. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc96.htm. Accessed 15 Feb 2011"},{"key":"269_CR12_269","unstructured":"World Health Organization Specifications and Evaluations for Public Health Pesticides (2002) Food and Agriculture Organization\/World Health Organization Evaluation Report 743\/2002. http:\/\/www.who.int\/whopes\/quality\/en\/prallethrin_spec_eval_Nov_2004.pdf. Accessed 15 Feb 2011"},{"key":"269_CR13_269","unstructured":"International Programme on Chemical Safety (1990) Environmental Health Criteria 98. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc98.htm. Accessed 15 Feb 2011"},{"key":"269_CR14_269","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/0048-3575(82)90082-7","volume":"18","author":"LJ Lawrence","year":"1982","unstructured":"Lawrence LJ, Casida JE (1982) Pyrethroid toxicology: mouse intracerebral structure-toxicity relationships. Pest Biochem Physiol 18:9\u201314","journal-title":"Pest Biochem Physiol"},{"key":"269_CR15_269","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.neuro.2009.08.014","volume":"30S","author":"ML Weiner","year":"2009","unstructured":"Weiner ML, Nemec M, Sheets L et al (2009) Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure. Neurotoxicol 30S:S1\u2013S16","journal-title":"Neurotoxicol"},{"key":"269_CR16_269","unstructured":"Tsuji R The classification of 7 pyrethroids based on the data of comparative Functional observation battery study in rats (in preparation)"},{"key":"269_CR17_269","volume-title":"Hay\u2019s handbook of pesticide toxicology","author":"DM Soderlund","year":"2010","unstructured":"Soderlund DM (2010) Toxicology and mode of action of pyrethroid insecticides. In: Krieger R (ed) Hay\u2019s handbook of pesticide toxicology, 3rd edn. Elsevier, Amsterdam","edition":"3"},{"key":"269_CR18_269","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/0048-3575(81)90084-5","volume":"15","author":"DW Gammon","year":"1981","unstructured":"Gammon DW, Brown MA, Casida JE (1981) Two class of pyrethroid action in the cockroach. Pest Biochem Physiol 15:181\u2013191","journal-title":"Pest Biochem Physiol"},{"key":"269_CR19_269","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/0892-0362(95)00008-F","volume":"17","author":"KM Crofton","year":"1995","unstructured":"Crofton KM, Kehn LS, Gilbert ME (1995) Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor activity in the rat. Neurotoxicol Teratol 17:489\u2013495","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR20_269","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ntt.2007.10.005","volume":"30","author":"MJ Wolansky","year":"2008","unstructured":"Wolansky MJ, Harrill JA (2008) Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review. Neurotoxicol Teratol 30:55\u201378","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR21_269","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.ntt.2007.01.007","volume":"29","author":"MJ Wolansky","year":"2007","unstructured":"Wolansky MJ, McDaniel KL, Moser VC et al (2007) Influence of dosing volume on the neurotoxicity of bifenthrin. Neurotoxicol Teratol 29:377\u2013384","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR22_269","doi-asserted-by":"publisher","first-page":"S17","DOI":"10.1016\/j.neuro.2009.09.002","volume":"30S","author":"CB Breckenridge","year":"2009","unstructured":"Breckenridge CB, Holden L, Sturgess N et al (2009) Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. Neurotoxicol 30S:S17\u2013S31","journal-title":"Neurotoxicol"},{"key":"269_CR23_269","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1289\/ehp.0900667","volume":"117","author":"MJ Wolansky","year":"2009","unstructured":"Wolansky MJ, Gennings C, DeVito MJ et al (2009) Evidence for dose-additive effects of pyrethroids on motor activity in rats. Environ Health Perspct 117:1563\u20131570","journal-title":"Environ Health Perspct"},{"key":"269_CR24_269","first-page":"53","volume":"1","author":"LW Reiter","year":"1979","unstructured":"Reiter LW, MacPhail RC (1979) Motor activity: a survey of methods with potential use in toxicity testing. Neurobehav Toxicol 1:53\u201366","journal-title":"Neurobehav Toxicol"},{"key":"269_CR25_269","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1039\/cs9780700473","volume":"7","author":"M Elliot","year":"1978","unstructured":"Elliot M, Janes NF (1978) Synthetic pyrethroids \u2013 a new class of insecticide. Chem Soc Rev 7:473\u2013505","journal-title":"Chem Soc Rev"},{"key":"269_CR26_269","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/0165-6147(92)90075-H","volume":"13","author":"T Narahashi","year":"1992","unstructured":"Narahashi T (1992) Nerve membrane Na\u2009+\u2009channels as target of insecticides. Trends Pharmacol Sci 13:236\u2013241","journal-title":"Trends Pharmacol Sci"},{"key":"269_CR27_269","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1007\/BF00334635","volume":"63","author":"F He","year":"1989","unstructured":"He F, Wang S, Liu L et al (1989) Clinical manifestations and diagnosis of acute pyrethroid poisoning. Arch Toxicol 63:54\u201358","journal-title":"Arch Toxicol"},{"key":"269_CR28_269","first-page":"26926","volume":"63","author":"US Environmental Protection Agency","year":"1998","unstructured":"US Environmental Protection Agency (1998) Guidelines for neurotoxicity risk assessment. Federal Register 63: 26926\u201326954 http:\/\/www.epa.gov\/raf\/publications\/pdfs\/NEUROTOX.PDF Accessed 15 Feb 2011","journal-title":"Federal Register"},{"key":"269_CR29_269","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/toxsci\/kfj020","volume":"89","author":"MJ Wolansky","year":"2006","unstructured":"Wolansky MJ, Gennings C, Crofton KM (2006) Relative potencies for acute effects of pyrethroids on motor function in rats. Toxicol Sci 89:271\u2013277","journal-title":"Toxicol Sci"},{"key":"269_CR30_269","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/0272-0590(88)90189-3","volume":"10","author":"KM Croton","year":"1988","unstructured":"Croton KM, Reiter LW (1988) The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat. Fundam Appl Toxicol 10:624\u2013634","journal-title":"Fundam Appl Toxicol"},{"key":"269_CR31_269","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/0041-008X(84)90214-X","volume":"75","author":"KM Crofton","year":"1984","unstructured":"Crofton KM, Reiter LW (1984) Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat. Toxicol Appl Pharmacol 75:318\u2013328","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR32_269","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/0378-4274(88)90155-5","volume":"40","author":"TH Hijzen","year":"1988","unstructured":"Hijzen TH, Slangen JL (1988) Effects of type I and II pyrethroids on the startle response in rats. Toxicol Lett 40:141\u2013152","journal-title":"Toxicol Lett"},{"key":"269_CR33_269","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0300-483X(88)90008-X","volume":"49","author":"TH Hijzen","year":"1988","unstructured":"Hijzen TH, Beun RD, Slangen JL (1988) Effects of pyrethroids on the acoustic startle reflex in the rat. Toxicol 49:271\u2013276","journal-title":"Toxicol"},{"key":"269_CR34_269","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/0892-0362(87)90035-3","volume":"9","author":"DB Peele","year":"1987","unstructured":"Peele DB, Crofton KM (1987) Pyrethroid effects on schedule-controlled behavior: time and dosage relationship. Neurotoxicol Teratol 9:387\u2013394","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR35_269","first-page":"321","volume":"5","author":"AS Bloom","year":"1983","unstructured":"Bloom AS, Staatz CG, Dieringer T (1983) Pyrethroid effects on operant responding and feeding. Neurobehav Toxicol Teratol 5:321\u2013324","journal-title":"Neurobehav Toxicol Teratol"},{"key":"269_CR36_269","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0892-0362(87)90066-3","volume":"9","author":"EA Stein","year":"1987","unstructured":"Stein EA, Washburn M, Walczak C et al (1987) Effects of pyrethroid insecticides on operant responding maintained by food. Neurotoxicol Teratol 9:27\u201331","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR37_269","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/BF00569234","volume":"50","author":"B Kolmodin-Hedman","year":"1982","unstructured":"Kolmodin-Hedman B, Swensson A, Akerblom M (1982) Occupational exposure to some synthetic pyrethroids (permethrin and fenvalerate). Arch Toxicol 50:27\u201333","journal-title":"Arch Toxicol"},{"issue":"83","key":"269_CR38_269","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/0378-4274(95)03604-0","volume":"82","author":"J Miyamoto","year":"1995","unstructured":"Miyamoto J, Kaneko H, Tsuji R et al (1995) Pyrethroids, nerve poisons: how their risk to human health should be assessed. Toxicol Lett 82(83):933\u2013940","journal-title":"Toxicol Lett"},{"key":"269_CR39_269","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1001\/archderm.1984.01650420054015","volume":"120","author":"JM Knox","year":"1984","unstructured":"Knox JM, Tucker SB, Flannigan SA (1984) Paresthesia from cutaneous exposure to synthetic pyrethroid insecticide. Arch Dermatol 120:744\u2013746","journal-title":"Arch Dermatol"},{"key":"269_CR40_269","first-page":"363","volume":"42","author":"SA Flannigan","year":"1985","unstructured":"Flannigan SA, Tucher SB, Key MM et al (1985) Synthetic pyrethroid insecticides, a dermatological evaluation. Br J Ind Med 42:363\u2013372","journal-title":"Br J Ind Med"},{"key":"269_CR41_269","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/0041-008X(84)90008-5","volume":"76","author":"SZ Cargen","year":"1984","unstructured":"Cargen SZ, Malley LA, Parker CM et al (1984) Pyrethroid-mediated skin sensory stimulation characterized by new behavioral paradigm. Toxicol Appl Pharmacol 76:270\u2013279","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR42_269","doi-asserted-by":"publisher","first-page":"183","DOI":"10.2174\/157015906778019482","volume":"4","author":"GM Story","year":"2006","unstructured":"Story GM (2006) The emerging role of TRP channels in mechanisms of temperature and pain sensation. Curr Neuropharmacol 4:183\u2013196","journal-title":"Curr Neuropharmacol"},{"key":"269_CR43_269","volume-title":"Casarett and Doull\u2019s toxicology, the basic science of poison","author":"LG Costa","year":"2007","unstructured":"Costa LG (2007) Toxic effects of pesticide. In: Klaassen CD (ed) Casarett and Doull\u2019s toxicology, the basic science of poison, 7th edn. McGraw Hill, New York","edition":"7"},{"key":"269_CR44_269","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/BF01969923","volume":"67","author":"F Cantalamessa","year":"1993","unstructured":"Cantalamessa F (1993) Acute toxicity of two pyrethroids, permethrin and cypermethrin in neonatal and adult rats. Arch Toxicol 67:510\u2013513","journal-title":"Arch Toxicol"},{"key":"269_CR45_269","first-page":"57","volume":"21","author":"LP Sheets","year":"2000","unstructured":"Sheets LP (2000) A consideration of age-dependent differences in susceptibility to organophosphorus and pyrethroid insecticides. Neurotoxicol 21:57\u201364","journal-title":"Neurotoxicol"},{"key":"269_CR46_269","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1124\/dmd.105.007807","volume":"34","author":"SS Anand","year":"2006","unstructured":"Anand SS, Kim KB, Padilla S et al (2006) Ontogeny of hepatic and plasma metabolism of deltamethrin in vitro: role in age-dependent acute neurootoxicity. Drug Metab Dispos 34:389\u2013397","journal-title":"Drug Metab Dispos"},{"key":"269_CR47_269","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1006\/taap.1994.1106","volume":"126","author":"LP Sheets","year":"1994","unstructured":"Sheets LP, Doherty JD, Law MW et al (1994) Age-dependent differences in the susceptibility of rats to deltamethrin. Toxicol Appl Pharmacol 126:186\u2013190","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR48_269","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1016\/0041-008X(90)90041-R","volume":"102","author":"P Eriksson","year":"1990","unstructured":"Eriksson P, Nordbrg A (1990) Effects of two pyrethroids, bioallethrin and deltamethrin, on subpopulations of muscarinic and nicotinic receptors in the neonatal mouse brain. Toxicol Appl Pharmacol 102:456\u2013463","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR49_269","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/0041-008X(91)90270-O","volume":"108","author":"P Eriksson","year":"1991","unstructured":"Eriksson P, Fredriksson A (1991) Neurotoxic effects of two different pyrethroids, bioallethrin and deltamethrin, on immature and adult mice: changes in behavioral and musucarinic receptor variables. Toxicol Appl Pharmacol 108:78\u201385","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR50_269","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/0006-8993(94)91666-7","volume":"645","author":"J Ahlbom","year":"1994","unstructured":"Ahlbom J, Fredriksson A, Eriksson P (1994) Neonatal exposure to a type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behavior in neonatal and adult mice. Brain Res 645:318\u2013324","journal-title":"Brain Res"},{"key":"269_CR51_269","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1002\/jat.873","volume":"23","author":"J Pauluhn","year":"2003","unstructured":"Pauluhn J, Schmuck G (2003) Critical analysis of potential body temperature confounders on neurochemical endpoints caused by direct dosing and maternal separation in neonatal mice: a study of bioallethrin and deltamethrin interactions with temperature on brain muscarinic receptors. J Appl Toxicol 23:9\u201318","journal-title":"J Appl Toxicol"},{"key":"269_CR52_269","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/jat.881","volume":"22","author":"R Tsuji","year":"2002","unstructured":"Tsuji R, Kobayashi K, Ikeda M et al (2002) Lack of changes in brain muscarinic receptor and motor activity of mice after neonatal inhalation exposure to d-allethrin. J Appl Toxicol 22:423\u2013429","journal-title":"J Appl Toxicol"},{"key":"269_CR53_269","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1289\/ehp.7254","volume":"113","author":"TJ Shafer","year":"2005","unstructured":"Shafer TJ, Meyer DA, Crofton KM (2005) Developmental neurotoxicity of pyrethroid insecticides: critical review and future research needs. Environ Health Perspect 113:123\u2013136","journal-title":"Environ Health Perspect"},{"key":"269_CR54_269","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1016\/S0892-0362(01)00170-2","volume":"23","author":"CA Lazarini","year":"2001","unstructured":"Lazarini CA, Florio JC, Lemonica IP et al (2001) Effects of perinatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats. Neurotoxicol Teratol 23:665\u2013673","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR55_269","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1016\/S0892-0362(99)00004-5","volume":"21","author":"AC Moniz","year":"1999","unstructured":"Moniz AC, Cruz-Casallas PE, Oliveira CA et al (1999) Perinatal fenvalerate exposure: behavioral and endocrinology changes in male rats. Neurotoxicol Teratol 21:611\u2013618","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR56_269","first-page":"119","volume":"35","author":"M Malaviya","year":"1993","unstructured":"Malaviya M, Husain R, Seth PK et al (1993) Perinatal effects of two pyrethroids insecticides on brain neurotransmitter function in the neonatal rat. Vet Hum Toxicol 35:119\u2013122","journal-title":"Vet Hum Toxicol"},{"key":"269_CR57_269","first-page":"1","volume":"921","author":"Panel on PPR in EFSA","year":"2009","unstructured":"Panel on PPR in EFSA (2009) Scientific opinion of the panel on plant protection products and their residues (PPR) on a request from the Europian Commission on potential developmental neurotoxicity of deltamethrin. EFSA J 921:1\u201334","journal-title":"EFSA J"},{"key":"269_CR58_269","unstructured":"US Environmental Protection Agency (2010) Pyrethroids: evaluation of data from developmental neurotoxicity studies and consideration of comparative sensitivity. EPA-HQ-OPP-2010-0378-0010. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2010-0378-0010. Accessed 15 Feb 2011"},{"key":"269_CR59_269","unstructured":"Toxic Substances and Disease Registry (ATSDR) (2003) Toxicological profile for pyrethrins and pyrethroids. U.S. Department of Health and Human Services, Public Health Service. Atlanta, GA. http:\/\/www.atsdr.cdc.gov\/ToxProfiles\/tp155.pdf. Accessed 14 Feb 2011"},{"key":"269_CR60_269","unstructured":"World Health Organization (2003) Specifications and evaluations for public health pesticides, Esbiothrin Evaluation Report 751. http:\/\/www.who.int\/whopes\/quality\/en\/Esbiothrin_spec_eval_Oct_2004.pdf. Accessed 14 Feb 2011"},{"key":"269_CR61_269","unstructured":"World Health Organization (2002) Specifications and evaluations for public health pesticides, d-Allethrin Evaluation Report 742 http:\/\/www.who.int\/whopes\/quality\/en\/dAllethrin_spec_eval_March_04.pdf. Accessed 14 Feb 2011"},{"key":"269_CR62_269","unstructured":"World Health Organization (1989) International Programme on Chemical Safety, Environmental Health Criteria 87 Allethrins. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc87.htm. Accessed 14 Feb 2011"},{"key":"269_CR63_269","unstructured":"European Chemicals Agency (2009) Proposal for Regulation on Classification, Labelling. CLP Report. http:\/\/echa.europa.eu\/doc\/consultations\/cl\/clh_axvrep_france_CD009321-73_bifentrin.pdf. Accessed 14 Feb 2011"},{"key":"269_CR64_269","unstructured":"US Environmental Protection Agency (2008) Human-Health Risk Assessment, EPA-HQ-OPP-2007-0535-0007. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2007-0535-0007. Accessed 14 Feb 2011"},{"key":"269_CR65_269","unstructured":"European Food Safety Authority (2008) Scientific Report 186, 1\u2013109. Conclusion on the peer review of bifenthrin. http:\/\/www.efsa.europa.eu\/en\/scdocs\/doc\/186r.pdf. Accessed 14 Feb 2011"},{"key":"269_CR66_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (1992) 838. Bifenthrin. Pesticide residues in food, evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v92pr04.htm. Accessed 14 Feb 2011"},{"key":"269_CR67_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (1991) 820. Bioresmethrin. Pesticide residues in food, evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v91pr04.htm. Accessed 14 Feb 2011"},{"key":"269_CR68_269","unstructured":"US Environmental Protection Agency (2010) Human Health Assessment Scoping Document in Support of Registration Review, Cyfluthrin\/Beta-cyfluthrin, EPA-HQ-OPP-2010-0684-0003. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2010-0684-0003. Accessed 14 Feb 2011"},{"key":"269_CR69_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (2006) Pesticide residues in food. Evaluations Part II toxicology, p 103. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v2006pr01.pdf. Accessed 14 Feb 2011"},{"key":"269_CR70_269","unstructured":"World Health Organization Specifications and Evaluations for Public Health Pesticide (2003) Cyfluthrin, Food and Agriculture Organization\/World Health Organization Evaluation Report 385 http:\/\/www.who.int\/whopes\/quality\/en\/Cyfluthrin_spec_eval_WHO_Nov_2004.pdf. Accessed 14 Feb 2011"},{"key":"269_CR71_269","unstructured":"International Programme on Chemical Safety (1997) World Health Organization, Food Additives Series 39. http:\/\/www.inchem.org\/documents\/jecfa\/jecmono\/v39je08.htm. Accessed 14 Feb 2011"},{"key":"269_CR72_269","unstructured":"US Environmental Protection Agency (2004) Federal Register\/Vol. 69, No. 68\/April 8, 2004\/Rules and Regulations 18480. http:\/\/edocket.access.gpo.gov\/2004\/pdf\/04-7979.pdf. Accessed 14 Feb 2011"},{"key":"269_CR73_269","unstructured":"International Programme on Chemical Safety (1990) Environmental Health Criteria 99. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc99.htm. Accessed 14 Feb 2011"},{"key":"269_CR74_269","unstructured":"US Environmental Protection Agency (2006, Revised in 2008). RED document, EPA-HQ-OPP-2005-0293-0046. http:\/\/www.epa.gov\/pesticides\/reregistration\/REDs\/cypermethrin_revised_red.pdf. Accessed 14 Feb 2011"},{"key":"269_CR75_269","unstructured":"European Food Safety Authority (2008) Scientific Report 196, 1\u2013119. Conclusion on the peer review of zeta-cypermethrin. http:\/\/www.efsa.europa.eu\/en\/scdocs\/doc\/196r.pdf. Accessed 14 Feb 2011"},{"key":"269_CR76_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (2006) Pesticide residues in Food. Evaluations Part II toxicology. p 157. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v2006pr01.pdf. Accessed 14 Feb 2011"},{"key":"269_CR77_269","unstructured":"World Health Organization (2005) Specifications and Evaluations for Public Health Pesticides, alpha-cypermethrin, Food and Agriculture Organization\/World Health Organization Evaluation Report 454. http:\/\/www.who.int\/whopes\/quality\/en\/Alphacypermethrin_eval_WHO_sep_2009.pdf. Accessed 14 Feb 2011"},{"key":"269_CR78_269","unstructured":"International Programme on Chemical Safety (1989) Environmental Health Criteria 82. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc82.htm. Accessed 14 Feb 2011"},{"key":"269_CR79_269","unstructured":"World Health Organization Specifications and Evaluations for Public Health Pesticides (2003) d,d,trans-Cyphenothrin, Food and Agriculture Organization\/World Health Organization Evaluation Report 761\/2003. http:\/\/www.who.int\/whopes\/quality\/en\/ddtrans-cyphenothrin_Spec_Eval_Sept_2005.pdf. Accessed 15 Feb 2011"},{"key":"269_CR80_269","unstructured":"World Health Organization Specifications and Evaluations for Public Health Pesticides (2004) Deltamethrin, Food and Agriculture Organization\/World Health Organization Evaluation Report 333\/2004. http:\/\/www.who.int\/whopes\/quality\/Deltamethrin_eval_specs_WHO_Jan_2010.pdf. Accessed 15 Feb 2011"},{"key":"269_CR81_269","unstructured":"US. Environmental Protection Agency (2004) Federal Register\/Vol. 69, No. 207\/ October 27, Rules and Regulations, 62602. http:\/\/edocket.access.gpo.gov\/2004\/pdf\/04-24040.pdf. Accessed 15 Feb 2011"},{"key":"269_CR82_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (2000) Pesticide residues in food. Evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v00pr04.htm. Accessed 15 Feb 2011"},{"key":"269_CR83_269","unstructured":"International Agency for Research on Cancer (1991) Monograph Vol.53. http:\/\/monographs.iarc.fr\/ENG\/Monographs\/vol53\/mono53-10.pdf. Accessed 15 Feb 2011"},{"key":"269_CR84_269","unstructured":"International Programme on Chemical Safety (1990) Environmental Health Criteria 97. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc97.htm. Accessed 15 Feb 2011"},{"key":"269_CR85_269","unstructured":"US Environmental Protection Agency (2004) EPA-HQ-OPP-2009-0301-0006. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2009-0301-0006. Accessed 15 Feb 2011"},{"key":"269_CR86_269","unstructured":"International Agency for Research on Cancer (1991) Monograph Vol.53. http:\/\/monographs.iarc.fr\/ENG\/Monographs\/vol53\/mono53-12.pdf. Accessed 15 Feb 2011"},{"key":"269_CR87_269","unstructured":"International Programme on Chemical Safety (1990) Environmental Health Criteria 95. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc95.htm. Accessed 15 Feb 2011"},{"key":"269_CR88_269","unstructured":"US Environmental Protection Agency (2008) Human Health Risk Assessment for Proposed Section 3 Uses on Rice and as ULV Mosquito Adulticide. EPA-HQ-OPP-2008-0567-0006. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2008-0567-0006. Accessed 15 Feb 2011"},{"key":"269_CR89_269","unstructured":"European Food Safety Authority (2008) Scientific Report 213, 1\u2013131. http:\/\/www.efsa.europa.eu\/en\/scdocs\/doc\/213r.pdf. Accessed 15 Feb 2011"},{"key":"269_CR90_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (1993) 863, Etofenprox. Pesticide residues in food. Evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v93pr09.htm. Accessed 15 Feb 2011"},{"key":"269_CR91_269","unstructured":"US Environmental Protection Agency (2008) EPA-HQ-OPP-2006-0875-0007. http:\/\/www.regulations.gov\/#!documentDetail;D=EPA-HQ-OPP-2006-0875-0007. Accessed 15 Feb 2011"},{"key":"269_CR92_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (1993) 864, Fenpropathrin, pesticide residues in food. Evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v93pr10.htm. Accessed 15 Feb 2011"},{"key":"269_CR93_269","unstructured":"New York State Department of Environmental Conservation (2008) http:\/\/pmep.cce.cornell.edu\/profiles\/insect-mite\/fenitrothion-methylpara\/metofluthrin\/metoflu_reg_0608.pdf. Accessed 15 Feb 2011"},{"key":"269_CR94_269","unstructured":"US Environmental Protection Agency (2009) RED document, EPA-HQ-OPP-2004-0385-0125. http:\/\/www.epa.gov\/oppsrrd1\/REDs\/permethrin-red-revised-may2009.pdf. Accessed 15 Feb 2011"},{"key":"269_CR95_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (1999) Pesticide residues in food. Evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v99pr07.htm. Accessed 15 Feb 2011"},{"key":"269_CR96_269","unstructured":"International Agency for Research on Cancer (1991) Monograph 53. http:\/\/monographs.iarc.fr\/ENG\/Monographs\/vol53\/mono53-13.pdf. Accessed 15 Feb 2011"},{"key":"269_CR97_269","unstructured":"US Environmental Protection Agency (2008) RED document, EPA-HQ-OPP-2008-0140-0030. http:\/\/www.epa.gov\/oppsrrd1\/REDs\/sumithrin_(d-phenothrin)_red.pdf. Accessed 15 Feb 2011"},{"key":"269_CR98_269","unstructured":"US. Environmental Protection Agency (2000) Federal Register\/Vol. 65, No. 123\/June 26, 2000\/Rules and Regulations 39304. http:\/\/frwebgate.access.gpo.gov\/cgi-bin\/getdoc.cgi?dbname=2000_register&docid=00-16077-filed.pdf. Accessed 15 Feb 2011"},{"key":"269_CR99_269","unstructured":"Joint Food and Agriculture Organization\/World Health Organization Meeting on Pesticide Residues (2003) Pesticide residues in food. Evaluations Part II toxicology. http:\/\/www.inchem.org\/documents\/jmpr\/jmpmono\/v2003pr11.htm. Accessed 15 Feb 2011"},{"key":"269_CR100_269","unstructured":"US Environmental Protection Agency (2006) RED document, EPA-HQ-OPP-2005-0284-0033. http:\/\/www.epa.gov\/oppsrrd1\/REDs\/resmethrin_red.pdf. Accessed 15 Feb 2011"},{"key":"269_CR101_269","unstructured":"International Programme on Chemical Safety (1989) Environmental Health Criteria 92. http:\/\/www.inchem.org\/documents\/ehc\/ehc\/ehc092.htm. Accessed 15 Feb 2011"},{"key":"269_CR102_269","unstructured":"US. Environmental Protection Agency (2005), Revised HED Chapter of the Reregistration Eligibility Decision Document, EPA-HQ-OPP-2005-0230-0003. http:\/\/www.epa.gov\/pesticides\/reregistration\/REDs\/taufluvalinate_red.pdf. Accessed 15 Feb 2011"},{"key":"269_CR103_269","unstructured":"Canada (2010) Re-evaluation Decision for Tefluthrin, RVD2010-07. http:\/\/www.hc-sc.gc.ca\/cps-spc\/alt_formats\/pdf\/pubs\/pest\/decisions\/rvd2010-07\/rvd2010-07-eng.pdf. Accessed 15 Feb 2011"},{"key":"269_CR104_269","unstructured":"US Environmental Protection Agency (1997) Federal Register\/Vol. 62, No. 228\/November 26\/Rules and Regulations 62954. http:\/\/frwebgate2.access.gpo.gov\/cgi-bin\/PDFgate.cgi?WAISdocID=oRgpai\/0\/2\/0&WAISaction=retrieve. Accessed 15 Feb 2011"},{"key":"269_CR105_269","unstructured":"US Environmental Protection Agency (2010) RED document, EPA-HQ-OPP-2008-0014-0029. http:\/\/www.epa.gov\/oppsrrd1\/REDs\/tetramethrin-red.pdf. Accessed 15 Feb 2011"},{"key":"269_CR106_269","unstructured":"US Environmental Protection Agency (2010) Human Health Assessment Scoping Document in Support of Registration Review EPA-HQ-OPP-2010-0116-0004. http:\/\/www.who.int\/whopes\/quality\/Transfluthrin_eval_only_Nov2006.pdf. Accessed 15 Feb 2011"},{"key":"269_CR107_269","unstructured":"World Health Organization Specifications and Evaluations for Public Health Pesticides (2002) Food and Agriculture Organization\/World Health Organization Evaluation Report 741\/2002. http:\/\/www.who.int\/whopes\/quality\/Transfluthrin_eval_only_Nov2006.pdf. Accessed 15 Feb 2011"},{"key":"269_CR108_269","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1080\/019262301753385979","volume":"29","author":"LS Gold","year":"2001","unstructured":"Gold LS, Manley NB, Slone TH et al (2001) Compendium of chemical carcinogens by target organ: results of chronic bioassays in rats, mice, hamsters, dogs, and monkeys. Toxicol Pathol 29:639\u2013652","journal-title":"Toxicol Pathol"},{"key":"269_CR109_269","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1093\/toxsci\/kfh159","volume":"80","author":"SM Cohen","year":"2004","unstructured":"Cohen SM (2004) Human carcinogenic risk evaluation: an alternative approach to the two-year rodent bioassay. Toxicol Sci 80:225\u2013229","journal-title":"Toxicol Sci"},{"key":"269_CR110_269","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1093\/toxsci\/kfj001","volume":"89","author":"MP Holsapple","year":"2006","unstructured":"Holsapple MP, Pitot HC, Cohen SM et al (2006) Mode of action in relevance of rodent liver tumors to human cancer risk. Toxicol Sci 89:51\u201356","journal-title":"Toxicol Sci"},{"key":"269_CR111_269","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1093\/toxsci\/kfh073","volume":"78","author":"SM Cohen","year":"2004","unstructured":"Cohen SM, Klaunig J, Meek ME et al (2004) Evaluating the human relevance of chemically induced animal tumors. Toxicol Sci 78:181\u2013186","journal-title":"Toxicol Sci"},{"key":"269_CR112_269","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1080\/713608373","volume":"33","author":"ME Meek","year":"2003","unstructured":"Meek ME, Bucher JR, Cohen SM et al (2003) A framework for human relevance analysis of information on carcinogenic modes of action. Crit Rev Toxicol 33:591\u2013653","journal-title":"Crit Rev Toxicol"},{"key":"269_CR113_269","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1080\/10408440600977677","volume":"36","author":"AR Boobis","year":"2006","unstructured":"Boobis AR, Cohen SM, Dellarco V et al (2006) IPCS framework for analyzing the relevance of a cancer mode of action for humans. Crit Rev Toxicol 36:781\u2013792","journal-title":"Crit Rev Toxicol"},{"key":"269_CR114_269","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1006\/rtph.2001.1493","volume":"34","author":"C Sonich-Mullin","year":"2001","unstructured":"Sonich-Mullin C, Fielder R, Wiltse J et al (2001) IPCS conceptual framework for evaluating a mode of action for chemical carcinogenesis. Regul Toxicol Pharmacol 34:146\u2013152","journal-title":"Regul Toxicol Pharmacol"},{"key":"269_CR115_269","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1093\/toxsci\/kfp006","volume":"108","author":"Y Deguchi","year":"2009","unstructured":"Deguchi Y, Yamada T, Hirose Y et al (2009) Mode of action analysis for the synthetic pyrethroid metofluthrin-induced rat liver tumors: evidence for hepatic CYP2B induction and hepatocyte proliferation. Toxicol Sci 108:69\u201380","journal-title":"Toxicol Sci"},{"key":"269_CR116_269","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.tox.2009.01.007","volume":"258","author":"Y Hirose","year":"2009","unstructured":"Hirose Y, Nagahori H, Yamada T et al (2009) Comparison of the effects of the synthetic pyrethroid metofluthrin and phenobarbital on CYP2B form induction and replicative DNA synthesis in cultured rat and human hepatocytes. Toxicology 258:64\u201369","journal-title":"Toxicology"},{"key":"269_CR117_269","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1093\/toxsci\/kfp007","volume":"108","author":"T Yamada","year":"2009","unstructured":"Yamada T, Uwagawa S, Okuno Y et al (2009) Case study: an evaluation of the human relevance of the synthetic pyrethroid metofluthrin-induced liver tumors in rats based on mode of action. Toxicol Sci 108:59\u201368","journal-title":"Toxicol Sci"},{"key":"269_CR118_269","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.tox.2007.09.031","volume":"243","author":"RJ Price","year":"2008","unstructured":"Price RJ, Giddings AM, Scott MP et al (2008) Effect of pyrethrins on cytochrome P450 forms in cultured rat and human hepatocytes. Toxicology 243:84\u201395","journal-title":"Toxicology"},{"key":"269_CR119_269","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0304-4165(02)00481-6","volume":"1619","author":"JT Moore","year":"2003","unstructured":"Moore JT, Moore LB, Maglich JM et al (2003) Functional and structural comparison of PXR and CAR. Biochim Biophys Acta 1619:235\u2013238","journal-title":"Biochim Biophys Acta"},{"key":"269_CR120_269","doi-asserted-by":"publisher","first-page":"1232","DOI":"10.1053\/jhep.2001.24172","volume":"33","author":"J Sugatani","year":"2001","unstructured":"Sugatani J, Kojima H, Ueda A et al (2001) The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR. Hepatology 33:1232\u20131238","journal-title":"Hepatology"},{"key":"269_CR121_269","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1007\/BF00542550","volume":"22","author":"HI Pirttiaho","year":"1982","unstructured":"Pirttiaho HI, Sotaniemi EA, Pelkonen RO et al (1982) Hepatic blood flow and drug metabolism in patients on enzyme-inducing anticonvulsants. Eur J Clin Pharmacol 22:441\u2013445","journal-title":"Eur J Clin Pharmacol"},{"key":"269_CR122_269","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0163-7258(98)00058-8","volume":"82","author":"SC Hasmall","year":"1999","unstructured":"Hasmall SC, Roberts RA (1999) The perturbation of apoptosis and mitosis by drugs and xenobiotics. Pharmacol Ther 82:63\u201370","journal-title":"Pharmacol Ther"},{"key":"269_CR123_269","first-page":"1143","volume":"51","author":"W Parzefall","year":"1991","unstructured":"Parzefall W, Erber E, Sedivy R et al (1991) Testing for induction of DNA synthesis in human hepatocyte primary cultures by rat liver tumor promoters. Cancer Res 51:1143\u20131147","journal-title":"Cancer Res"},{"key":"269_CR124_269","unstructured":"IARC (2001) IARC monographs on the evaluation of carcinogenic risks to humans. Some thyrotropic agents, Lyon"},{"key":"269_CR125_269","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1093\/jnci\/81.10.803","volume":"81","author":"JH Olsen","year":"1989","unstructured":"Olsen JH, Boice JD Jr, Jensen JP et al (1989) Cancer among epileptic patients exposed to anticonvulsant drugs. J Natl Cancer Inst 81:803\u2013808","journal-title":"J Natl Cancer Inst"},{"key":"269_CR126_269","first-page":"294","volume":"55","author":"JH Olsen","year":"1995","unstructured":"Olsen JH, Schulgen G, Boice JD Jr et al (1995) Antiepileptic treatment and risk for hepatobiliary cancer and malignant lymphoma. Cancer Res 55:294\u2013297","journal-title":"Cancer Res"},{"key":"269_CR127_269","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/0163-7258(96)00067-8","volume":"71","author":"J Whysner","year":"1996","unstructured":"Whysner J, Ross PM, Williams GM (1996) Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion. Pharmacol Ther 71:153\u2013191","journal-title":"Pharmacol Ther"},{"key":"269_CR128_269","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.taap.2006.01.009","volume":"214","author":"JM Finch","year":"2006","unstructured":"Finch JM, Osimitz TG, Gabriel KL et al (2006) A mode of action for induction of thyroid gland tumors by pyrethrins in the rat. Toxicol Appl Pharmacol 214:253\u2013262","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR129_269","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1080\/10408440902914014","volume":"39","author":"TG Osimitz","year":"2009","unstructured":"Osimitz TG, Lake BG (2009) Mode-of-action analysis for induction of rat liver tumors by pyrethrins: relevance to human cancer risk. Crit Rev Toxicol 39:501\u2013511","journal-title":"Crit Rev Toxicol"},{"key":"269_CR130_269","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.taap.2006.11.004","volume":"218","author":"RJ Price","year":"2007","unstructured":"Price RJ, Walters DG, Finch JM et al (2007) A mode of action for induction of liver tumors by pyrethrins in the rat. Toxicol Appl Pharmacol 218:186\u2013195","journal-title":"Toxicol Appl Pharmacol"},{"key":"269_CR131_269","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1080\/10408440600975242","volume":"36","author":"VL Dellarco","year":"2006","unstructured":"Dellarco VL, McGregor D, Berry SC et al (2006) Thiazopyr and thyroid disruption: case study within the context of the 2006 IPCS Human Relevance Framework for analysis of a cancer mode of action. Crit Rev Toxicol 36:793\u2013801","journal-title":"Crit Rev Toxicol"},{"key":"269_CR132_269","unstructured":"Organization of Teratology Information Specialists (2009) Pesticides and pregnancy. tttp:\/\/www.otispregnancy.org\/files\/pesticides.pdf. Accessed 24 Jan 2011"},{"key":"269_CR133_269","first-page":"21A","volume":"38","author":"AA Komeil","year":"1988","unstructured":"Komeil AA, Abdalla MA, Younis HM et al (1988) Teratogenicity of three different insecticides in pregnant mice (abstract). Teratology 38:21A","journal-title":"Teratology"},{"key":"269_CR134_269","first-page":"565","volume":"12","author":"L Sylianco-Wu","year":"1989","unstructured":"Sylianco-Wu L, Kallman M, Wilson M et al (1989) Behavioral and neurochemical consequences of perinatal exposure to type I and type II pyrethroid formulations. Neurotoxicol Teratol 12:565","journal-title":"Neurotoxicol Teratol"},{"key":"269_CR135_269","first-page":"142","volume":"100","author":"MM Abdel-Khalik","year":"1993","unstructured":"Abdel-Khalik MM, Hanafy MS, Abdel-Aziz MI (1993) Studies on the teratogenic effects of deltamethrin in rats. Dtsch Tierarztl Wochenschr 100:142\u2013143","journal-title":"Dtsch Tierarztl Wochenschr"},{"key":"269_CR136_269","first-page":"751","volume":"2","author":"R Kavlock","year":"1979","unstructured":"Kavlock R, Chernoff N, Baron R et al (1979) Toxicity studies with decamethrin, a synthetic pyrethroid insecticide. J Environ Pathol Toxicol 2:751\u2013765","journal-title":"J Environ Pathol Toxicol"},{"key":"269_CR137_269","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1289\/ehp.761415","volume":"14","author":"J Miyamoto","year":"1976","unstructured":"Miyamoto J (1976) Degradation, metabolism and toxicity of synthetic pyrethroids. Environ Health Perspect 14:15\u201328","journal-title":"Environ Health Perspect"},{"key":"269_CR138_269","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1007\/BF01606093","volume":"29","author":"F Spencer","year":"1982","unstructured":"Spencer F, Behane Z (1982) Uterine and fetal characteristics in rats following a post-implantational exposure to permethrin. Bull Environ Contam Toxicol 29:84\u201388","journal-title":"Bull Environ Contam Toxicol"},{"key":"269_CR139_269","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1055\/s-2005-837736","volume":"22","author":"D Kennedy","year":"2005","unstructured":"Kennedy D, Hurst V, Konradsdottir E, Einarson A (2005) Pergnacy outcome following exposure to permethrin and use of teratogen information. Am J Perinatol 22:87\u201390","journal-title":"Am J Perinatol"},{"key":"269_CR140_269","first-page":"121","volume":"11","author":"PK Gupta","year":"1990","unstructured":"Gupta PK (1990) Teratogenic effects of cypermethrin in rats. J Environ Biol 11:121\u2013126","journal-title":"J Environ Biol"},{"issue":"1-S","key":"269_CR141_269","first-page":"320","volume":"66","author":"JD McCarty","year":"2002","unstructured":"McCarty JD, Freeman C, Watt BA (2002) Comparison of dietary and oral gavage administration of bifenthrin in developmental toxicity studies in Sprague-Dawley rats. Toxicologist 66(1-S):320","journal-title":"Toxicologist"},{"key":"269_CR142_269","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1080\/15287398409530483","volume":"13","author":"CM Parker","year":"1984","unstructured":"Parker CM, Patterson DR, Van Gelder GA et al (1984) Chronic toxicity and carcinogenicity evaluation of fenvalerate in rats. J Toxicol Environ Health 13:83\u201397","journal-title":"J Toxicol Environ Health"},{"key":"269_CR143_269","first-page":"15","volume":"19","author":"J He","year":"2006","unstructured":"He J, Chen JF, Liu R et al (2006) Fenvalerate-induced alterations in calcium homeostasis in rat ovary. Biomed Environ Sci 19:15\u201320","journal-title":"Biomed Environ Sci"},{"key":"269_CR144_269","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1080\/15287390802392024","volume":"71","author":"AC Arena","year":"2008","unstructured":"Arena AC, Fernadez CD, Porto EM et al (2008) Fenvalerate, a pyrethroid insecticide, adversely affects sperm production and storage in male rats. J Toxicol Environ Health A 71:1550\u20131558","journal-title":"J Toxicol Environ Health A"},{"key":"269_CR145_269","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1080\/15287390701738517","volume":"71","author":"L Song","year":"2008","unstructured":"Song L, Wang YB, Sun H et al (2008) Effects of fenvalerate and cypermethrin on rat sperm motility patterns in vitro as measured by computer-assisted sperm analysis. J Toxicol Environ Health A 71:325\u2013332","journal-title":"J Toxicol Environ Health A"},{"key":"269_CR146_269","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.reprotox.2005.05.007","volume":"21","author":"H Xiao","year":"2006","unstructured":"Xiao H, Zhang XC, Zhang L et al (2006) Fenvalerate modifies T-type Ca2+ channels in mouse spermatogenic cells. Reprod Toxicol 21:48\u201353","journal-title":"Reprod Toxicol"},{"key":"269_CR147_269","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.contraception.2005.06.067","volume":"73","author":"T Lifeng","year":"2006","unstructured":"Lifeng T, Shoulin W, Junmin J et al (2006) Effects of fenvalerate exposure on sperm quality among occupational workers. Contraception 73:92\u201396","journal-title":"Contraception"},{"key":"269_CR148_269","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0300-483X(98)00114-0","volume":"132","author":"M EI-Gohary","year":"1999","unstructured":"EI-Gohary M, Awara WM, Nassar S et al (1999) Deltamethrin-induced testicular apotosis in rats: the protective effect of nitric oxide synthase inhibitor. Toxicology 132:1\u20138","journal-title":"Toxicology"},{"key":"269_CR149_269","doi-asserted-by":"publisher","first-page":"663","DOI":"10.2131\/jts.34.663","volume":"34","author":"C Issam","year":"2009","unstructured":"Issam C, Samir H, Zohra H et al (2009) Toxic responses to deltamethrin low doses on gonads, sex hormones and lipoperoxidation in male rats following subcutaneous treatments. J Toxicol Sci 34:663\u2013670","journal-title":"J Toxicol Sci"},{"key":"269_CR150_269","first-page":"259","volume":"21","author":"Y Shukla","year":"2002","unstructured":"Shukla Y, Taneja P (2002) Mutagenic potential of cypermethrin in mouse dominant lethal assay. J Environ Pathol Toxicol Oncol 21:259\u2013265","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"269_CR151_269","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1007\/s002440010280","volume":"41","author":"A Elbetieha","year":"2001","unstructured":"Elbetieha A, Da\u2019as SI, Khamas W et al (2001) Evaluation of the toxic potentials of cypermethrin pesticide on some reproductive and fertility parameters in the male rats. Arch Environ Contam Toxicol 41:522\u2013528","journal-title":"Arch Environ Contam Toxicol"},{"key":"269_CR152_269","first-page":"149","volume":"9","author":"N Ahmed","year":"1988","unstructured":"Ahmed N, Gupta PK (1988) Reproduction one generation toxicity of cypermethrin in rats. J Environ Biol 9:149\u2013156","journal-title":"J Environ Biol"},{"key":"269_CR153_269","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.reprotox.2007.01.002","volume":"23","author":"AT Farag","year":"2007","unstructured":"Farag AT, Goda NF, Shaaban NA et al (2007) Effects of oral exposure of synthetic pyrethroid, cypermethrin on the behavior of F1-progeny in mice. Reprod Toxicol 23:560\u2013567","journal-title":"Reprod Toxicol"},{"key":"269_CR154_269","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1262\/jrd.16060","volume":"51","author":"SS Kim","year":"2005","unstructured":"Kim SS, Lee RD, Lim KJ et al (2005) Potential estrogenic and antiandrogenic effects of permethrin in rats. J Reprod Dev 51:201\u2013210","journal-title":"J Reprod Dev"},{"key":"269_CR155_269","first-page":"333","volume":"65","author":"SS Kim","year":"2002","unstructured":"Kim SS, Rhee GS, Kim SH et al (2002) Permethrin affects reproductive development in rats. Teratology 65:333","journal-title":"Teratology"},{"key":"269_CR156_269","doi-asserted-by":"publisher","first-page":"3941","DOI":"10.1210\/en.2006-1497","volume":"148","author":"SY Zhang","year":"2007","unstructured":"Zhang SY, Ito Y, Yamanoshita O et al (2007) Permethrin may disrupt testosterone biosynthesis via mitochondrial membrane damage of Leydig cells in adult male mouse. Endocrinology 148:3941\u20133949","journal-title":"Endocrinology"},{"key":"269_CR157_269","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2131\/jts.31.1","volume":"31","author":"A Srivastava","year":"2006","unstructured":"Srivastava A, Srivastava MK, Raizada RB (2006) Ninety-day toxicity and one-generation reproduction study in rats exposed to allethrin-based liquid mosquito repellent. J Toxicol Sci 31:1\u20137","journal-title":"J Toxicol Sci"},{"key":"269_CR158_269","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1080\/15287390491009327","volume":"68","author":"SS Kim","year":"2005","unstructured":"Kim SS, Kwack SJ, Lee RD et al (2005) Assessment of estrogenic and androgenic activities of tetramethrin in vitro and in vivo assays. J Toxicol Environ Health A 68:2277\u20132289","journal-title":"J Toxicol Environ Health A"},{"key":"269_CR159_269","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1262\/jrd.50.245","volume":"50","author":"IY Kim","year":"2004","unstructured":"Kim IY, Shin JH, Kim HS et al (2004) Assessing estrogenic activity of pyrethroid insecticides using in vitro combination assays. J Reprod Dev 50:245\u2013255","journal-title":"J Reprod Dev"},{"key":"269_CR160_269","first-page":"350","volume":"67","author":"SS Kim","year":"2003","unstructured":"Kim SS, Rhee GS, Kwack SJ et al (2003) Neonatal exposure to sumithrin shows estrogen-like effects in prepubertal rat development. Birth Defects Res Part A Clin Mol Teratol 67:350","journal-title":"Birth Defects Res Part A Clin Mol Teratol"},{"key":"269_CR161_269","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/S0300-483X(02)00750-3","volume":"186","author":"T Yamada","year":"2003","unstructured":"Yamada T, Ueda S, Yoshioka K et al (2003) Lack of estrogenic or (anti-)androgenic effects of d-phenothrin in the uterotropic and Hershberger assays. Toxicology 186:227\u2013239","journal-title":"Toxicology"}],"container-title":["Topics in Current Chemistry","Pyrethroids"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/128_2011_269","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,11]],"date-time":"2023-02-11T09:16:57Z","timestamp":1676107017000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/128_2011_269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011]]},"ISBN":["9783642273452","9783642273469"],"references-count":162,"URL":"https:\/\/doi.org\/10.1007\/128_2011_269","relation":{},"ISSN":["0340-1022","1436-5049"],"issn-type":[{"value":"0340-1022","type":"print"},{"value":"1436-5049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011]]},"assertion":[{"value":"21 October 2011","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}