{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:59:24Z","timestamp":1770634764575,"version":"3.49.0"},"publisher-location":"Berlin, Heidelberg","reference-count":131,"publisher":"Springer Berlin Heidelberg","isbn-type":[{"value":"9783642345746","type":"print"},{"value":"9783642345753","type":"electronic"}],"license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012]]},"DOI":"10.1007\/128_2012_344","type":"book-chapter","created":{"date-parts":[[2012,7,31]],"date-time":"2012-07-31T11:26:54Z","timestamp":1343734014000},"page":"35-60","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Cancer Chemopreventive and Therapeutic Potential of Guggulsterone"],"prefix":"10.1007","author":[{"given":"Inas","family":"Almazari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Joon","family":"Surh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,8,1]]},"reference":[{"key":"344_CR1","doi-asserted-by":"publisher","first-page":"69","DOI":"10.3322\/caac.20107","volume":"61","author":"A Jemal","year":"2011","unstructured":"Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D (2011) Global cancer statistics. CA Cancer J Clin 61:69\u201390","journal-title":"CA Cancer J Clin"},{"key":"344_CR2","first-page":"567","volume":"17","author":"HC Pitot","year":"1993","unstructured":"Pitot HC (1993) Multistage carcinogenesis \u2013 genetic and epigenetic mechanisms in relation to cancer prevention. Cancer Detect Prev 17:567\u2013573","journal-title":"Cancer Detect Prev"},{"key":"344_CR3","first-page":"294","volume":"33","author":"S De Flora","year":"2011","unstructured":"De Flora S, La Maestra S, Micale RT (2011) [Mechanistic issues and prevention strategies targeting occupational carcinogenesis]. G Ital Med Lav Ergon 33:294\u2013299","journal-title":"G Ital Med Lav Ergon"},{"key":"344_CR4","doi-asserted-by":"publisher","first-page":"150","DOI":"10.3322\/canjclin.54.3.150","volume":"54","author":"AS Tsao","year":"2004","unstructured":"Tsao AS, Kim ES, Hong WK (2004) Chemoprevention of cancer. CA Cancer J Clin 54:150\u2013180","journal-title":"CA Cancer J Clin"},{"key":"344_CR5","first-page":"2699","volume":"36","author":"MB Sporn","year":"1976","unstructured":"Sporn MB (1976) Approaches to prevention of epithelial cancer during the preneoplastic period. Cancer Res 36:2699\u20132702","journal-title":"Cancer Res"},{"key":"344_CR6","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1038\/nrc1189","volume":"3","author":"YJ Surh","year":"2003","unstructured":"Surh YJ (2003) Cancer chemoprevention with dietary phytochemicals. Nat Rev Cancer 3:768\u2013780","journal-title":"Nat Rev Cancer"},{"key":"344_CR7","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1517\/13543784.13.10.1327","volume":"13","author":"BB Aggarwal","year":"2004","unstructured":"Aggarwal BB, Takada Y, Oommen OV (2004) From chemoprevention to chemotherapy: common targets and common goals. Expert Opin Investig Drugs 13:1327\u20131338","journal-title":"Expert Opin Investig Drugs"},{"key":"344_CR8","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1007\/s10529-007-9342-5","volume":"29","author":"M Mathur","year":"2007","unstructured":"Mathur M, Ramawat KG (2007) Guggulsterone production in cell suspension cultures of the guggul tree, Commiphora wightii, grown in shake-flasks and bioreactors. Biotechnol Lett 29:979\u2013982","journal-title":"Biotechnol Lett"},{"key":"344_CR9","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1158\/1535-7163.MCT-07-0491","volume":"7","author":"D Xiao","year":"2008","unstructured":"Xiao D, Singh SV (2008) z-Guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, inhibits angiogenesis in vitro and in vivo. Mol Cancer Ther 7:171\u2013180","journal-title":"Mol Cancer Ther"},{"key":"344_CR10","doi-asserted-by":"publisher","first-page":"3","DOI":"10.5507\/bp.2005.001","volume":"149","author":"LO Hanus","year":"2005","unstructured":"Hanus LO, Rezanka T, Dembitsky VM, Moussaieff A (2005) Myrrh \u2013 Commiphora chemistry. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 149:3\u201327","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"344_CR11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1527-3466.2007.00023.x","volume":"25","author":"R Deng","year":"2007","unstructured":"Deng R (2007) Therapeutic effects of guggul and its constituent guggulsterone: cardiovascular benefits. Cardiovasc Drug Rev 25:375\u2013390","journal-title":"Cardiovasc Drug Rev"},{"key":"344_CR12","first-page":"3647","volume":"28","author":"S Shishodia","year":"2008","unstructured":"Shishodia S, Harikumar KB, Dass S, Ramawat KG, Aggarwal BB (2008) The guggul for chronic diseases: ancient medicine, modern targets. Anticancer Res 28:3647\u20133664","journal-title":"Anticancer Res"},{"key":"344_CR13","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.taap.2009.11.028","volume":"254","author":"JE Klaunig","year":"2011","unstructured":"Klaunig JE, Wang Z, Pu X, Zhou S (2011) Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol Appl Pharmacol 254:86\u201399","journal-title":"Toxicol Appl Pharmacol"},{"key":"344_CR14","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.3748\/wjg.15.1702","volume":"15","author":"JS Pan","year":"2009","unstructured":"Pan JS, Hong MZ, Ren JL (2009) Reactive oxygen species: a double-edged sword in oncogenesis. World J Gastroenterol 15:1702\u20131707","journal-title":"World J Gastroenterol"},{"key":"344_CR15","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/j.1939-1676.2011.00836.x","volume":"26","author":"WB Morrison","year":"2012","unstructured":"Morrison WB (2012) Inflammation and cancer: a comparative view. J Vet Intern Med 26:18\u201331","journal-title":"J Vet Intern Med"},{"key":"344_CR16","unstructured":"Shacter E, Weitzman SA (2002) Chronic inflammation and cancer. Oncology (Williston Park) 16:217\u2013226, 229; discussion 230\u2013212"},{"key":"344_CR17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.pbb.2007.03.010","volume":"86","author":"G Saxena","year":"2007","unstructured":"Saxena G, Singh SP, Pal R, Singh S, Pratap R, Nath C (2007) Gugulipid, an extract of Commiphora whighitii with lipid-lowering properties, has protective effects against streptozotocin-induced memory deficits in mice. Pharmacol Biochem Behav 86:797\u2013805","journal-title":"Pharmacol Biochem Behav"},{"key":"344_CR18","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/j.atherosclerosis.2003.10.008","volume":"172","author":"X Wang","year":"2004","unstructured":"Wang X, Greilberger J, Ledinski G, Kager G, Paigen B, Jurgens G (2004) The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Atherosclerosis 172:239\u2013246","journal-title":"Atherosclerosis"},{"key":"344_CR19","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/(SICI)1099-1573(199706)11:4<291::AID-PTR96>3.0.CO;2-R","volume":"11","author":"K Singh","year":"1997","unstructured":"Singh K, Chander R, Kapoor NK (1997) Guggulsterone, a potent hypolipidaemic, prevents oxidation of low density lipoprotein. Phytother Res 11:291\u2013294","journal-title":"Phytother Res"},{"key":"344_CR20","first-page":"1190","volume":"43","author":"HB Xu","year":"2008","unstructured":"Xu HB, Li L, Liu GQ (2008) Protection against hydrogen peroxide-induced cytotoxicity in PC12 cells by guggulsterone. Yao Xue Xue Bao 43:1190\u20131197","journal-title":"Yao Xue Xue Bao"},{"key":"344_CR21","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.bcp.2009.06.026","volume":"78","author":"A Mencarelli","year":"2009","unstructured":"Mencarelli A, Renga B, Palladino G, Distrutti E, Fiorucci S (2009) The plant sterol guggulsterone attenuates inflammation and immune dysfunction in murine models of inflammatory bowel disease. Biochem Pharmacol 78:1214\u20131223","journal-title":"Biochem Pharmacol"},{"key":"344_CR22","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1007\/s00395-008-0757-5","volume":"104","author":"C Gebhard","year":"2009","unstructured":"Gebhard C, Stampfli SF, Gebhard CE, Akhmedov A, Breitenstein A, Camici GG, Holy EW, Luscher TF, Tanner FC (2009) Guggulsterone, an anti-inflammatory phytosterol, inhibits tissue factor and arterial thrombosis. Basic Res Cardiol 104:285\u2013294","journal-title":"Basic Res Cardiol"},{"key":"344_CR23","doi-asserted-by":"publisher","first-page":"47148","DOI":"10.1074\/jbc.M408093200","volume":"279","author":"S Shishodia","year":"2004","unstructured":"Shishodia S, Aggarwal BB (2004) Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem 279:47148\u201347158","journal-title":"J Biol Chem"},{"key":"344_CR24","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1016\/j.lfs.2008.04.006","volume":"82","author":"YR Lee","year":"2008","unstructured":"Lee YR, Lee JH, Noh EM, Kim EK, Song MY, Jung WS, Park SJ, Kim JS, Park JW, Kwon KB et al (2008) Guggulsterone blocks IL-1beta-mediated inflammatory responses by suppressing NF-kappaB activation in fibroblast-like synoviocytes. Life Sci 82:1203\u20131209","journal-title":"Life Sci"},{"key":"344_CR25","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.coph.2007.03.002","volume":"7","author":"D Khanna","year":"2007","unstructured":"Khanna D, Sethi G, Ahn KS, Pandey MK, Kunnumakkara AB, Sung B, Aggarwal A, Aggarwal BB (2007) Natural products as a gold mine for arthritis treatment. Curr Opin Pharmacol 7:344\u2013351","journal-title":"Curr Opin Pharmacol"},{"key":"344_CR26","doi-asserted-by":"publisher","first-page":"5105","DOI":"10.1167\/iovs.09-4873","volume":"51","author":"NM Kalariya","year":"2010","unstructured":"Kalariya NM, Shoeb M, Reddy AB, Zhang M, van Kuijk FJ, Ramana KV (2010) Prevention of endotoxin-induced uveitis in rats by plant sterol guggulsterone. Invest Ophthalmol Vis Sci 51:5105\u20135113","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"344_CR27","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1097\/01.mib.0000235830.94057.c6","volume":"12","author":"JH Cheon","year":"2006","unstructured":"Cheon JH, Kim JS, Kim JM, Kim N, Jung HC, Song IS (2006) Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis. Inflamm Bowel Dis 12:1152\u20131161","journal-title":"Inflamm Bowel Dis"},{"key":"344_CR28","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1124\/mol.104.007054","volume":"67","author":"TP Burris","year":"2005","unstructured":"Burris TP, Montrose C, Houck KA, Osborne HE, Bocchinfuso WP, Yaden BC, Cheng CC, Zink RW, Barr RJ, Hepler CD et al (2005) The hypolipidemic natural product guggulsterone is a promiscuous steroid receptor ligand. Mol Pharmacol 67:948\u2013954","journal-title":"Mol Pharmacol"},{"key":"344_CR29","doi-asserted-by":"publisher","first-page":"2631","DOI":"10.1016\/j.fct.2009.07.021","volume":"47","author":"B Sharma","year":"2009","unstructured":"Sharma B, Salunke R, Srivastava S, Majumder C, Roy P (2009) Effects of guggulsterone isolated from Commiphora mukul in high fat diet induced diabetic rats. Food Chem Toxicol 47:2631\u20132639","journal-title":"Food Chem Toxicol"},{"key":"344_CR30","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.cbi.2010.01.008","volume":"184","author":"M Moya","year":"2010","unstructured":"Moya M, Gomez-Lechon MJ, Castell JV, Jover R (2010) Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile. Chem Biol Interact 184:376\u2013387","journal-title":"Chem Biol Interact"},{"key":"344_CR31","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0006-291X(03)00551-5","volume":"304","author":"E Owsley","year":"2003","unstructured":"Owsley E, Chiang JY (2003) Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene. Biochem Biophys Res Commun 304:191\u2013195","journal-title":"Biochem Biophys Res Commun"},{"key":"344_CR32","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1210\/me.16.7.1590","volume":"16","author":"J Wu","year":"2002","unstructured":"Wu J, Xia C, Meier J, Li S, Hu X, Lala DS (2002) The hypolipidemic natural product guggulsterone acts as an antagonist of the bile acid receptor. Mol Endocrinol 16:1590\u20131597","journal-title":"Mol Endocrinol"},{"key":"344_CR33","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/1476-4598-5-48","volume":"5","author":"A De Gottardi","year":"2006","unstructured":"De Gottardi A, Dumonceau JM, Bruttin F, Vonlaufen A, Morard I, Spahr L, Rubbia-Brandt L, Frossard JL, Dinjens WN, Rabinovitch PS et al (2006) Expression of the bile acid receptor FXR in Barrett\u2019s esophagus and enhancement of apoptosis by guggulsterone in vitro. Mol Cancer 5:48","journal-title":"Mol Cancer"},{"key":"344_CR34","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1038\/bjc.2011.37","volume":"104","author":"JY Lee","year":"2011","unstructured":"Lee JY, Lee KT, Lee JK, Lee KH, Jang KT, Heo JS, Choi SH, Kim Y, Rhee JC (2011) Farnesoid X receptor, overexpressed in pancreatic cancer with lymph node metastasis promotes cell migration and invasion. Br J Cancer 104:1027\u20131037","journal-title":"Br J Cancer"},{"key":"344_CR35","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.mce.2008.02.001","volume":"289","author":"N Lv","year":"2008","unstructured":"Lv N, Song MY, Kim EK, Park JW, Kwon KB, Park BH (2008) Guggulsterone, a plant sterol, inhibits NF-kappaB activation and protects pancreatic beta cells from cytokine toxicity. Mol Cell Endocrinol 289:49\u201359","journal-title":"Mol Cell Endocrinol"},{"key":"344_CR36","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0031-9422(02)00388-6","volume":"62","author":"MR Meselhy","year":"2003","unstructured":"Meselhy MR (2003) Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents. Phytochemistry 62:213\u2013218","journal-title":"Phytochemistry"},{"key":"344_CR37","first-page":"371","volume":"24","author":"R Chander","year":"2002","unstructured":"Chander R, Khanna AK, Kapoor NK (2002) Antioxidant activity of guggulsterone, the active principle of guggulipid from Commiphora mukul. J Med Aromatic Plant Sci 24:371\u2013375","journal-title":"J Med Aromatic Plant Sci"},{"key":"344_CR38","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1093\/carcin\/bgn180","volume":"29","author":"S Sarfaraz","year":"2008","unstructured":"Sarfaraz S, Siddiqui IA, Syed DN, Afaq F, Mukhtar H (2008) Guggulsterone modulates MAPK and NF-kappaB pathways and inhibits skin tumorigenesis in SENCAR mice. Carcinogenesis 29:2011\u20132018","journal-title":"Carcinogenesis"},{"key":"344_CR39","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/j.jep.2009.12.012","volume":"127","author":"R Niranjan","year":"2010","unstructured":"Niranjan R, Kamat PK, Nath C, Shukla R (2010) Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). J Ethnopharmacol 127:625\u2013630","journal-title":"J Ethnopharmacol"},{"key":"344_CR40","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1093\/carcin\/bgr259","volume":"33","author":"I Almazari","year":"2012","unstructured":"Almazari I, Park JM, Park SA, Suh JY, Na HK, Cha YN, Surh YJ (2012) Guggulsterone induces heme oxygenase-1 expression through activation of Nrf2 in human mammary epithelial cells: PTEN as a putative target. Carcinogenesis 33:368\u2013376","journal-title":"Carcinogenesis"},{"key":"344_CR41","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1038\/labinvest.2010.54","volume":"90","author":"JM Kim","year":"2010","unstructured":"Kim JM, Kang HW, Cha MY, Yoo D, Kim N, Kim IK, Ku J, Kim S, Ma SH, Jung HC et al (2010) Novel guggulsterone derivative GG-52 inhibits NF-kappaB signaling in intestinal epithelial cells and attenuates acute murine colitis. Lab Invest 90:1004\u20131015","journal-title":"Lab Invest"},{"key":"344_CR42","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1038\/sj.mp.4000679","volume":"4","author":"S Rivest","year":"1999","unstructured":"Rivest S (1999) Activation of the nuclear factor kappa B (NF-kappaB) and cyclooxygenase-2 (COX-2) genes in cerebral blood vessels in response to systemic inflammation. Mol Psychiatry 4:500","journal-title":"Mol Psychiatry"},{"key":"344_CR43","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1053\/j.gastro.2009.02.049","volume":"136","author":"R Caruso","year":"2009","unstructured":"Caruso R, Sarra M, Stolfi C, Rizzo A, Fina D, Fantini MC, Pallone F, MacDonald TT, Monteleone G (2009) Interleukin-25 inhibits interleukin-12 production and Th1 cell-driven inflammation in the gut. Gastroenterology 136:2270\u20132279","journal-title":"Gastroenterology"},{"key":"344_CR44","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1084\/jem.188.10.1929","volume":"188","author":"M Boirivant","year":"1998","unstructured":"Boirivant M, Fuss IJ, Chu A, Strober W (1998) Oxazolone colitis: a murine model of T helper cell type 2 colitis treatable with antibodies to interleukin 4. J Exp Med 188:1929\u20131939","journal-title":"J Exp Med"},{"key":"344_CR45","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.intimp.2008.10.012","volume":"9","author":"HS Youn","year":"2009","unstructured":"Youn HS, Ahn SI, Lee BY (2009) Guggulsterone suppresses the activation of transcription factor IRF3 induced by TLR3 or TLR4 agonists. Int Immunopharmacol 9:108\u2013112","journal-title":"Int Immunopharmacol"},{"key":"344_CR46","first-page":"1294","volume":"17","author":"SI Ahn","year":"2008","unstructured":"Ahn SI, Youn HS (2008) Guggulsterone suppresses the activation of NF-\u03baB and expression of COX-2 induced by toll-like receptor 2, 3, and 4 agonists. Food Sci Biotechnol 17:1294\u20131298","journal-title":"Food Sci Biotechnol"},{"key":"344_CR47","doi-asserted-by":"publisher","first-page":"1842","DOI":"10.1002\/cbdv.200490138","volume":"1","author":"JA Francis","year":"2004","unstructured":"Francis JA, Raja SN, Nair MG (2004) Bioactive terpenoids and guggulusteroids from Commiphora mukul gum resin of potential anti-inflammatory interest. Chem Biodivers 1:1842\u20131853","journal-title":"Chem Biodivers"},{"key":"344_CR48","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1089\/jmf.2008.0158","volume":"12","author":"S Rayalam","year":"2009","unstructured":"Rayalam S, Yang JY, Della-Fera MA, Park HJ, Ambati S, Baile CA (2009) Anti-obesity effects of xanthohumol plus guggulsterone in 3T3-L1 adipocytes. J Med Food 12:846\u2013853","journal-title":"J Med Food"},{"key":"344_CR49","doi-asserted-by":"publisher","first-page":"7439","DOI":"10.1158\/0008-5472.CAN-07-0120","volume":"67","author":"SV Singh","year":"2007","unstructured":"Singh SV, Choi S, Zeng Y, Hahm ER, Xiao D (2007) Guggulsterone-induced apoptosis in human prostate cancer cells is caused by reactive oxygen intermediate dependent activation of c-Jun NH2-terminal kinase. Cancer Res 67:7439\u20137449","journal-title":"Cancer Res"},{"key":"344_CR50","first-page":"1321","volume":"20","author":"ES Kim","year":"2008","unstructured":"Kim ES, Hong SY, Lee HK, Kim SW, An MJ, Kim TI, Lee KR, Kim WH, Cheon JH (2008) Guggulsterone inhibits angiogenesis by blocking STAT3 and VEGF expression in colon cancer cells. Oncol Rep 20:1321\u20131327","journal-title":"Oncol Rep"},{"key":"344_CR51","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1186\/1471-2407-10-655","volume":"10","author":"MA Macha","year":"2010","unstructured":"Macha MA, Matta A, Chauhan S, Siu KM, Ralhan R (2010) 14-3-3 Zeta is a molecular target in guggulsterone induced apoptosis in head and neck cancer cells. BMC Cancer 10:655","journal-title":"BMC Cancer"},{"key":"344_CR52","first-page":"660","volume":"64","author":"HB Xu","year":"2009","unstructured":"Xu HB, Li L, Liu GQ (2009) Reversal of P-glycoprotein-mediated multidrug resistance by guggulsterone in doxorubicin-resistant human myelogenous leukemia (K562\/DOX) cells. Pharmazie 64:660\u2013665","journal-title":"Pharmazie"},{"key":"344_CR53","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1016\/j.bcp.2011.08.019","volume":"82","author":"DO Moon","year":"2011","unstructured":"Moon DO, Park SY, Choi YH, Ahn JS, Kim GY (2011) Guggulsterone sensitizes hepatoma cells to TRAIL-induced apoptosis through the induction of CHOP-dependent DR5: involvement of ROS-dependent ER-stress. Biochem Pharmacol 82:1641\u20131650","journal-title":"Biochem Pharmacol"},{"key":"344_CR54","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1158\/1078-0432.CCR-05-1749","volume":"12","author":"H Ichikawa","year":"2006","unstructured":"Ichikawa H, Aggarwal BB (2006) Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res 12:662\u2013668","journal-title":"Clin Cancer Res"},{"key":"344_CR55","first-page":"1953","volume":"30","author":"T Yamada","year":"2010","unstructured":"Yamada T, Osawa S, Hamaya Y, Furuta T, Hishida A, Kajimura M, Ikuma M (2010) Guggulsterone suppresses bile acid-induced and constitutive caudal-related homeobox 2 expression in gut-derived adenocarcinoma cells. Anticancer Res 30:1953\u20131960","journal-title":"Anticancer Res"},{"key":"344_CR56","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1159\/000321484","volume":"57","author":"HB Xu","year":"2011","unstructured":"Xu HB, Li L, Liu GQ (2011) Reversal of multidrug resistance by guggulsterone in drug-resistant MCF-7 cell lines. Chemotherapy 57:62\u201370","journal-title":"Chemotherapy"},{"key":"344_CR57","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1158\/1535-7163.MCT-05-0247","volume":"4","author":"I Samudio","year":"2005","unstructured":"Samudio I, Konopleva M, Safe S, McQueen T, Andreeff M (2005) Guggulsterones induce apoptosis and differentiation in acute myeloid leukemia: identification of isomer-specific antileukemic activities of the pregnadienedione structure. Mol Cancer Ther 4:1982\u20131992","journal-title":"Mol Cancer Ther"},{"key":"344_CR58","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1158\/0008-5472.CAN-07-6696","volume":"68","author":"KS Ahn","year":"2008","unstructured":"Ahn KS, Sethi G, Sung B, Goel A, Ralhan R, Aggarwal BB (2008) Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1. Cancer Res 68:4406\u20134415","journal-title":"Cancer Res"},{"key":"344_CR59","doi-asserted-by":"publisher","first-page":"e14728","DOI":"10.1371\/journal.pone.0014728","volume":"6","author":"MA Macha","year":"2011","unstructured":"Macha MA, Matta A, Chauhan SS, Siu KW, Ralhan R (2011) Guggulsterone targets smokeless tobacco induced PI3K\/Akt pathway in head and neck cancer cells. PLoS One 6:e14728","journal-title":"PLoS One"},{"key":"344_CR60","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1093\/carcin\/bgq278","volume":"32","author":"MA Macha","year":"2011","unstructured":"Macha MA, Matta A, Chauhan SS, Siu KW, Ralhan R (2011) Guggulsterone (GS) inhibits smokeless tobacco and nicotine-induced NF-kappaB and STAT3 pathways in head and neck cancer cells. Carcinogenesis 32:368\u2013380","journal-title":"Carcinogenesis"},{"key":"344_CR61","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.1093\/carcin\/bgp211","volume":"30","author":"RJ Leeman-Neill","year":"2009","unstructured":"Leeman-Neill RJ, Wheeler SE, Singh SV, Thomas SM, Seethala RR, Neill DB, Panahandeh MC, Hahm ER, Joyce SC, Sen M et al (2009) Guggulsterone enhances head and neck cancer therapies via inhibition of signal transducer and activator of transcription-3. Carcinogenesis 30:1848\u20131856","journal-title":"Carcinogenesis"},{"key":"344_CR62","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.bcp.2007.03.026","volume":"74","author":"S Shishodia","year":"2007","unstructured":"Shishodia S, Sethi G, Ahn KS, Aggarwal BB (2007) Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochem Pharmacol 74:118\u2013130","journal-title":"Biochem Pharmacol"},{"key":"344_CR63","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1124\/mol.110.068551","volume":"79","author":"D Xiao","year":"2011","unstructured":"Xiao D, Zeng Y, Prakash L, Badmaev V, Majeed M, Singh SV (2011) Reactive oxygen species-dependent apoptosis by gugulipid extract of ayurvedic medicine plant Commiphora mukul in human prostate cancer cells is regulated by c-Jun N-terminal kinase. Mol Pharmacol 79:499\u2013507","journal-title":"Mol Pharmacol"},{"key":"344_CR64","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1158\/1535-7163.MCT-05-0223","volume":"4","author":"SV Singh","year":"2005","unstructured":"Singh SV, Zeng Y, Xiao D, Vogel VG, Nelson JB, Dhir R, Tripathi YB (2005) Caspase-dependent apoptosis induction by guggulsterone, a constituent of ayurvedic medicinal plant Commiphora mukul, in PC-3 human prostate cancer cells is mediated by Bax and Bak. Mol Cancer Ther 4:1747\u20131754","journal-title":"Mol Cancer Ther"},{"key":"344_CR65","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.canlet.2009.01.026","volume":"279","author":"MJ An","year":"2009","unstructured":"An MJ, Cheon JH, Kim SW, Kim ES, Kim TI, Kim WH (2009) Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts. Cancer Lett 279:93\u2013100","journal-title":"Cancer Lett"},{"key":"344_CR66","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1038\/oby.2007.24","volume":"16","author":"JY Yang","year":"2008","unstructured":"Yang JY, Della-Fera MA, Baile CA (2008) Guggulsterone inhibits adipocyte differentiation and induces apoptosis in 3T3-L1 cells. Obesity (Silver Spring) 16:16\u201322","journal-title":"Obesity (Silver Spring)"},{"key":"344_CR67","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00262-003-0474-8","volume":"53","author":"KM Debatin","year":"2004","unstructured":"Debatin KM (2004) Apoptosis pathways in cancer and cancer therapy. Cancer Immunol Immunother 53:153\u2013159","journal-title":"Cancer Immunol Immunother"},{"key":"344_CR68","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.bbamcr.2003.11.002","volume":"1644","author":"MR Sprick","year":"2004","unstructured":"Sprick MR, Walczak H (2004) The interplay between the Bcl-2 family and death receptor-mediated apoptosis. Biochim Biophys Acta 1644:125\u2013132","journal-title":"Biochim Biophys Acta"},{"key":"344_CR69","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1634\/theoncologist.11-4-342","volume":"11","author":"MS Ricci","year":"2006","unstructured":"Ricci MS, Zong WX (2006) Chemotherapeutic approaches for targeting cell death pathways. Oncologist 11:342\u2013357","journal-title":"Oncologist"},{"key":"344_CR70","doi-asserted-by":"publisher","first-page":"478","DOI":"10.1093\/oxfordjournals.bmb.a011625","volume":"53","author":"NA Thornberry","year":"1997","unstructured":"Thornberry NA (1997) The caspase family of cysteine proteases. Br Med Bull 53:478\u2013490","journal-title":"Br Med Bull"},{"key":"344_CR71","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/S0092-8674(04)00046-7","volume":"116","author":"NN Danial","year":"2004","unstructured":"Danial NN, Korsmeyer SJ (2004) Cell death: critical control points. Cell 116:205\u2013219","journal-title":"Cell"},{"key":"344_CR72","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/S0008-6363(00)00268-6","volume":"49","author":"I Zachary","year":"2001","unstructured":"Zachary I, Gliki G (2001) Signaling transduction mechanisms mediating biological actions of the vascular endothelial growth factor family. Cardiovasc Res 49:568\u2013581","journal-title":"Cardiovasc Res"},{"key":"344_CR73","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1194\/jlr.M500473-JLR200","volume":"47","author":"J Silva","year":"2006","unstructured":"Silva J, Dasgupta S, Wang G, Krishnamurthy K, Ritter E, Bieberich E (2006) Lipids isolated from bone induce the migration of human breast cancer cells. J Lipid Res 47:724\u2013733","journal-title":"J Lipid Res"},{"key":"344_CR74","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/bcr2211","volume":"10","author":"K Krishnamurthy","year":"2008","unstructured":"Krishnamurthy K, Wang G, Rokhfeld D, Bieberich E (2008) Deoxycholate promotes survival of breast cancer cells by reducing the level of pro-apoptotic ceramide. Breast Cancer Res 10:R106","journal-title":"Breast Cancer Res"},{"key":"344_CR75","first-page":"815","volume":"43","author":"LW Chung","year":"1997","unstructured":"Chung LW, Kao C, Sikes RA, Zhau HE (1997) Human prostate cancer progression models and therapeutic intervention. Hinyokika Kiyo 43:815\u2013820","journal-title":"Hinyokika Kiyo"},{"key":"344_CR76","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.2741\/1625","volume":"10","author":"S Kambhampati","year":"2005","unstructured":"Kambhampati S, Ray G, Sengupta K, Reddy VP, Banerjee SK, Van Veldhuizen PJ (2005) Growth factors involved in prostate carcinogenesis. Front Biosci 10:1355\u20131367","journal-title":"Front Biosci"},{"key":"344_CR77","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S1097-2765(05)00012-2","volume":"6","author":"SR Datta","year":"2000","unstructured":"Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME (2000) 14-3-3 Proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6:41\u201351","journal-title":"Mol Cell"},{"key":"344_CR78","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1016\/S0092-8674(00)81382-3","volume":"87","author":"J Zha","year":"1996","unstructured":"Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ (1996) Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 87:619\u2013628","journal-title":"Cell"},{"key":"344_CR79","doi-asserted-by":"publisher","first-page":"2058","DOI":"10.1074\/jbc.M207880200","volume":"278","author":"M Nomura","year":"2003","unstructured":"Nomura M, Shimizu S, Sugiyama T, Narita M, Ito T, Matsuda H, Tsujimoto Y (2003) 14-3-3 Interacts directly with and negatively regulates pro-apoptotic Bax. J Biol Chem 278:2058\u20132065","journal-title":"J Biol Chem"},{"key":"344_CR80","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nrc1141","volume":"3","author":"Y Yuasa","year":"2003","unstructured":"Yuasa Y (2003) Control of gut differentiation and intestinal-type gastric carcinogenesis. Nat Rev Cancer 3:592\u2013600","journal-title":"Nat Rev Cancer"},{"key":"344_CR81","doi-asserted-by":"publisher","first-page":"593","DOI":"10.4161\/cbt.3.7.913","volume":"3","author":"RJ Guo","year":"2004","unstructured":"Guo RJ, Suh ER, Lynch JP (2004) The role of Cdx proteins in intestinal development and cancer. Cancer Biol Ther 3:593\u2013601","journal-title":"Cancer Biol Ther"},{"key":"344_CR82","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1042\/BST0380353","volume":"38","author":"F Beck","year":"2010","unstructured":"Beck F, Stringer EJ (2010) The role of Cdx genes in the gut and in axial development. Biochem Soc Trans 38:353\u2013357","journal-title":"Biochem Soc Trans"},{"key":"344_CR83","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/ng1265","volume":"35","author":"K Aoki","year":"2003","unstructured":"Aoki K, Tamai Y, Horiike S, Oshima M, Taketo MM (2003) Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+\/Delta716 Cdx2+\/\u2212 compound mutant mice. Nat Genet 35:323\u2013330","journal-title":"Nat Genet"},{"key":"344_CR84","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1136\/gut.52.10.1465","volume":"52","author":"C Bonhomme","year":"2003","unstructured":"Bonhomme C, Duluc I, Martin E, Chawengsaksophak K, Chenard MP, Kedinger M, Beck F, Freund JN, Domon-Dell C (2003) The Cdx2 homeobox gene has a tumour suppressor function in the distal colon in addition to a homeotic role during gut development. Gut 52:1465\u20131471","journal-title":"Gut"},{"key":"344_CR85","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1038\/sj.onc.1209247","volume":"25","author":"LH Dang","year":"2006","unstructured":"Dang LH, Chen F, Ying C, Chun SY, Knock SA, Appelman HD, Dang DT (2006) CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene 25:2264\u20132272","journal-title":"Oncogene"},{"key":"344_CR86","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.1053\/j.gastro.2005.12.032","volume":"130","author":"PR Debruyne","year":"2006","unstructured":"Debruyne PR, Witek M, Gong L, Birbe R, Chervoneva I, Jin T, Domon-Cell C, Palazzo JP, Freund JN, Li P et al (2006) Bile acids induce ectopic expression of intestinal guanylyl cyclase C through nuclear factor-kappaB and Cdx2 in human esophageal cells. Gastroenterology 130:1191\u20131206","journal-title":"Gastroenterology"},{"key":"344_CR87","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1002\/hep.20869","volume":"42","author":"A Anan","year":"2005","unstructured":"Anan A, Gores GJ (2005) A new TRAIL to therapy of hepatocellular carcinoma: blocking the proteasome. Hepatology 42:527\u2013529","journal-title":"Hepatology"},{"key":"344_CR88","first-page":"116","volume":"25","author":"SQ He","year":"2003","unstructured":"He SQ, Chen Y, Chen XP, Zhang WG, Wang HP, Zhao YZ, Wang SF (2003) [Antitumor effects of soluble TRAIL in human hepatocellular carcinoma]. Zhonghua Zhong Liu Za Zhi 25:116\u2013119","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"344_CR89","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00280-011-1686-9","volume":"69","author":"JF Yang","year":"2012","unstructured":"Yang JF, Cao JG, Tian L, Liu F (2012) 5,7-Dimethoxyflavone sensitizes TRAIL-induced apoptosis through DR5 upregulation in hepatocellular carcinoma cells. Cancer Chemother Pharmacol 69:195\u2013206","journal-title":"Cancer Chemother Pharmacol"},{"key":"344_CR90","doi-asserted-by":"publisher","first-page":"229","DOI":"10.4161\/cbt.12.3.17033","volume":"12","author":"W Wang","year":"2011","unstructured":"Wang W, Gallant JN, Katz SI, Dolloff NG, Smith CD, Abdulghani J, Allen JE, Dicker DT, Hong B, Navaraj A et al (2011) Quinacrine sensitizes hepatocellular carcinoma cells to TRAIL and chemotherapeutic agents. Cancer Biol Ther 12:229\u2013238","journal-title":"Cancer Biol Ther"},{"key":"344_CR91","doi-asserted-by":"publisher","first-page":"5924","DOI":"10.3748\/wjg.15.5924","volume":"15","author":"BC Koehler","year":"2009","unstructured":"Koehler BC, Urbanik T, Vick B, Boger RJ, Heeger S, Galle PR, Schuchmann M, Schulze-Bergkamen H (2009) TRAIL-induced apoptosis of hepatocellular carcinoma cells is augmented by targeted therapies. World J Gastroenterol 15:5924\u20135935","journal-title":"World J Gastroenterol"},{"key":"344_CR92","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1097\/CAD.0b013e32832e8998","volume":"20","author":"CY Jin","year":"2009","unstructured":"Jin CY, Park C, Moon SK, Kim GY, Kwon TK, Lee SJ, Kim WJ, Choi YH (2009) Genistein sensitizes human hepatocellular carcinoma cells to TRAIL-mediated apoptosis by enhancing Bid cleavage. Anticancer Drugs 20:713\u2013722","journal-title":"Anticancer Drugs"},{"key":"344_CR93","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/j.bcp.2011.12.035","volume":"83","author":"KF Chen","year":"2012","unstructured":"Chen KF, Chen HL, Liu CY, Tai WT, Ichikawa K, Chen PJ, Cheng AL (2012) Dovitinib sensitizes hepatocellular carcinoma cells to TRAIL and tigatuzumab, a novel anti-DR5 antibody, through SHP-1-dependent inhibition of STAT3. Biochem Pharmacol 83:769\u2013777","journal-title":"Biochem Pharmacol"},{"key":"344_CR94","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1002\/jcp.22494","volume":"226","author":"D Carlisi","year":"2011","unstructured":"Carlisi D, D\u2019Anneo A, Angileri L, Lauricella M, Emanuele S, Santulli A, Vento R, Tesoriere G (2011) Parthenolide sensitizes hepatocellular carcinoma cells to TRAIL by inducing the expression of death receptors through inhibition of STAT3 activation. J Cell Physiol 226:1632\u20131641","journal-title":"J Cell Physiol"},{"key":"344_CR95","first-page":"41","volume":"18","author":"Y Yamanaka","year":"2006","unstructured":"Yamanaka Y, Shiraki K, Inoue T, Miyashita K, Fuke H, Yamaguchi Y, Yamamoto N, Ito K, Sugimoto K, Nakano T (2006) COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis. Int J Mol Med 18:41\u201347","journal-title":"Int J Mol Med"},{"key":"344_CR96","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s13238-010-0019-9","volume":"1","author":"P Huang","year":"2010","unstructured":"Huang P, Han J, Hui L (2010) MAPK signaling in inflammation-associated cancer development. Protein Cell 1:218\u2013226","journal-title":"Protein Cell"},{"key":"344_CR97","doi-asserted-by":"publisher","first-page":"3279","DOI":"10.1038\/sj.onc.1210421","volume":"26","author":"AS Dhillon","year":"2007","unstructured":"Dhillon AS, Hagan S, Rath O, Kolch W (2007) MAP kinase signalling pathways in cancer. Oncogene 26:3279\u20133290","journal-title":"Oncogene"},{"key":"344_CR98","doi-asserted-by":"publisher","first-page":"4146","DOI":"10.1038\/sj.onc.1207490","volume":"23","author":"Y Ren","year":"2004","unstructured":"Ren Y, Chan HM, Li Z, Lin C, Nicholls J, Chen CF, Lee PY, Lui V, Bacher M, Tam PK (2004) Upregulation of macrophage migration inhibitory factor contributes to induced N-Myc expression by the activation of ERK signaling pathway and increased expression of interleukin-8 and VEGF in neuroblastoma. Oncogene 23:4146\u20134154","journal-title":"Oncogene"},{"key":"344_CR99","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/jcp.20025","volume":"200","author":"B Yang","year":"2004","unstructured":"Yang B, Cao DJ, Sainz I, Colman RW, Guo YL (2004) Different roles of ERK and p38 MAP kinases during tube formation from endothelial cells cultured in 3-dimensional collagen matrices. J Cell Physiol 200:360\u2013369","journal-title":"J Cell Physiol"},{"key":"344_CR100","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1016\/j.cellsig.2011.01.005","volume":"23","author":"Y Liu","year":"2011","unstructured":"Liu Y, Mei C, Sun L, Li X, Liu M, Wang L, Li Z, Yin P, Zhao C, Shi Y et al (2011) The PI3K-Akt pathway regulates calpain 6 expression, proliferation, and apoptosis. Cell Signal 23:827\u2013836","journal-title":"Cell Signal"},{"key":"344_CR101","doi-asserted-by":"publisher","first-page":"564","DOI":"10.2478\/s11658-011-0023-y","volume":"16","author":"JG Huang","year":"2011","unstructured":"Huang JG, Xia C, Zheng XP, Yi TT, Wang XY, Song G, Zhang B (2011) 17beta-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K\/Akt pathway. Cell Mol Biol Lett 16:564\u2013575","journal-title":"Cell Mol Biol Lett"},{"key":"344_CR102","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1002\/cbf.1668","volume":"28","author":"J Yang","year":"2010","unstructured":"Yang J, Zhang X, Wang W, Liu J (2010) Insulin stimulates osteoblast proliferation and differentiation through ERK and PI3K in MG-63 cells. Cell Biochem Funct 28:334\u2013341","journal-title":"Cell Biochem Funct"},{"key":"344_CR103","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.neuint.2011.03.027","volume":"59","author":"A Vazquez de la Torre","year":"2011","unstructured":"Vazquez de la Torre A, Junyent F, Folch J, Pelegri C, Vilaplana J, Auladell C, Beas-Zarate C, Pallas M, Camins A, Verdaguer E (2011) Study of the pathways involved in apoptosis induced by PI3K inhibition in cerebellar granule neurons. Neurochem Int 59:159\u2013167","journal-title":"Neurochem Int"},{"key":"344_CR104","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.virol.2007.09.003","volume":"370","author":"SJ Jeong","year":"2008","unstructured":"Jeong SJ, Dasgupta A, Jung KJ, Um JH, Burke A, Park HU, Brady JN (2008) PI3K\/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology 370:264\u2013272","journal-title":"Virology"},{"key":"344_CR105","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1016\/j.jep.2011.01.015","volume":"134","author":"DN Gunadharini","year":"2011","unstructured":"Gunadharini DN, Elumalai P, Arunkumar R, Senthilkumar K, Arunakaran J (2011) Induction of apoptosis and inhibition of PI3K\/Akt pathway in PC-3 and LNCaP prostate cancer cells by ethanolic neem leaf extract. J Ethnopharmacol 134:644\u2013650","journal-title":"J Ethnopharmacol"},{"key":"344_CR106","doi-asserted-by":"publisher","first-page":"1895","DOI":"10.1016\/j.bcp.2010.07.014","volume":"80","author":"A Paine","year":"2010","unstructured":"Paine A, Eiz-Vesper B, Blasczyk R, Immenschuh S (2010) Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol 80:1895\u20131903","journal-title":"Biochem Pharmacol"},{"key":"344_CR107","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1096\/fj.04-3099fje","volume":"19","author":"JE Jung","year":"2005","unstructured":"Jung JE, Lee HG, Cho IH, Chung DH, Yoon SH, Yang YM, Lee JW, Choi S, Park JW, Ye SK et al (2005) STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells. FASEB J 19:1296\u20131298","journal-title":"FASEB J"},{"key":"344_CR108","doi-asserted-by":"publisher","first-page":"e21492","DOI":"10.1371\/journal.pone.0021492","volume":"6","author":"J Shin","year":"2011","unstructured":"Shin J, Lee HJ, Jung DB, Jung JH, Lee EO, Lee SG, Shim BS, Choi SH, Ko SG, Ahn KS et al (2011) Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. PLoS One 6:e21492","journal-title":"PLoS One"},{"key":"344_CR109","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s00428-005-1264-9","volume":"446","author":"X Dolcet","year":"2005","unstructured":"Dolcet X, Llobet D, Pallares J, Matias-Guiu X (2005) NF-kB in development and progression of human cancer. Virchows Arch 446:475\u2013482","journal-title":"Virchows Arch"},{"key":"344_CR110","doi-asserted-by":"publisher","first-page":"45193","DOI":"10.1074\/jbc.M105971200","volume":"276","author":"SC Masters","year":"2001","unstructured":"Masters SC, Fu H (2001) 14-3-3 Proteins mediate an essential anti-apoptotic signal. J Biol Chem 276:45193\u201345200","journal-title":"J Biol Chem"},{"key":"344_CR111","doi-asserted-by":"publisher","first-page":"2676","DOI":"10.1158\/1535-7163.MCT-10-0312","volume":"9","author":"A Matta","year":"2010","unstructured":"Matta A, DeSouza LV, Ralhan R, Siu KW (2010) Small interfering RNA targeting 14-3-3zeta increases efficacy of chemotherapeutic agents in head and neck cancer cells. Mol Cancer Ther 9:2676\u20132688","journal-title":"Mol Cancer Ther"},{"key":"344_CR112","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.tem.2011.07.005","volume":"22","author":"S Chen","year":"2011","unstructured":"Chen S, Synowsky S, Tinti M, MacKintosh C (2011) The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends Endocrinol Metab 22:429\u2013436","journal-title":"Trends Endocrinol Metab"},{"key":"344_CR113","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1210\/me.16.3.552","volume":"16","author":"X Xiang","year":"2002","unstructured":"Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z (2002) 14-3-3 Facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1. Mol Endocrinol 16:552\u2013562","journal-title":"Mol Endocrinol"},{"key":"344_CR114","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-60761-416-6_1","volume":"596","author":"BC Baguley","year":"2010","unstructured":"Baguley BC (2010) Multidrug resistance in cancer. Methods Mol Biol 596:1\u201314","journal-title":"Methods Mol Biol"},{"key":"344_CR115","first-page":"1","volume":"9","author":"MF Ullah","year":"2008","unstructured":"Ullah MF (2008) Cancer multidrug resistance (MDR): a major impediment to effective chemotherapy. Asian Pac J Cancer Prev 9:1\u20136","journal-title":"Asian Pac J Cancer Prev"},{"key":"344_CR116","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1111\/j.1755-148X.2009.00630.x","volume":"22","author":"KG Chen","year":"2009","unstructured":"Chen KG, Valencia JC, Gillet JP, Hearing VJ, Gottesman MM (2009) Involvement of ABC transporters in melanogenesis and the development of multidrug resistance of melanoma. Pigment Cell Melanoma Res 22:740\u2013749","journal-title":"Pigment Cell Melanoma Res"},{"key":"344_CR117","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00280-010-1515-6","volume":"68","author":"Y Li","year":"2011","unstructured":"Li Y, Revalde JL, Reid G, Paxton JW (2011) Modulatory effects of curcumin on multi-drug resistance-associated protein 5 in pancreatic cancer cells. Cancer Chemother Pharmacol 68:603\u2013610","journal-title":"Cancer Chemother Pharmacol"},{"key":"344_CR118","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1248\/bpb.33.255","volume":"33","author":"T Okura","year":"2010","unstructured":"Okura T, Ibe M, Umegaki K, Shinozuka K, Yamada S (2010) Effects of dietary ingredients on function and expression of P-glycoprotein in human intestinal epithelial cells. Biol Pharm Bull 33:255\u2013259","journal-title":"Biol Pharm Bull"},{"key":"344_CR119","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s11010-009-0267-2","volume":"336","author":"S Prasad","year":"2010","unstructured":"Prasad S, Ravindran J, Aggarwal BB (2010) NF-kappaB and cancer: how intimate is this relationship. Mol Cell Biochem 336:25\u201337","journal-title":"Mol Cell Biochem"},{"key":"344_CR120","doi-asserted-by":"publisher","first-page":"1695","DOI":"10.1016\/S0024-3205(01)00967-5","volume":"68","author":"Y Nomura","year":"2001","unstructured":"Nomura Y (2001) NF-kappaB activation and IkappaB alpha dynamism involved in iNOS and chemokine induction in astroglial cells. Life Sci 68:1695\u20131701","journal-title":"Life Sci"},{"key":"344_CR121","first-page":"187","volume":"36","author":"A Pandey","year":"2011","unstructured":"Pandey A, Forte V, Abdallah M, Alickaj A, Mahmud S, Asad S, McFarlane SI (2011) Diabetes mellitus and the risk of cancer. Minerva Endocrinol 36:187\u2013209","journal-title":"Minerva Endocrinol"},{"key":"344_CR122","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1042\/BJ20101603","volume":"437","author":"J Wesche","year":"2011","unstructured":"Wesche J, Haglund K, Haugsten EM (2011) Fibroblast growth factors and their receptors in cancer. Biochem J 437:199\u2013213","journal-title":"Biochem J"},{"key":"344_CR123","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1038\/nrc2780","volume":"10","author":"N Turner","year":"2010","unstructured":"Turner N, Grose R (2010) Fibroblast growth factor signalling: from development to cancer. Nat Rev Cancer 10:116\u2013129","journal-title":"Nat Rev Cancer"},{"key":"344_CR124","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1007\/s10555-006-9006-2","volume":"25","author":"SB Jakowlew","year":"2006","unstructured":"Jakowlew SB (2006) Transforming growth factor-beta in cancer and metastasis. Cancer Metastasis Rev 25:435\u2013457","journal-title":"Cancer Metastasis Rev"},{"key":"344_CR125","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.ghir.2004.01.005","volume":"14","author":"YH Ibrahim","year":"2004","unstructured":"Ibrahim YH, Yee D (2004) Insulin-like growth factor-I and cancer risk. Growth Horm IGF Res 14:261\u2013269","journal-title":"Growth Horm IGF Res"},{"key":"344_CR126","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/S0165-5728(02)00003-6","volume":"124","author":"G Conti","year":"2002","unstructured":"Conti G, De Pol A, Scarpini E, Vaccina F, De Riz M, Baron P, Tiriticco M, Scarlato G (2002) Interleukin-1 beta and interferon-gamma induce proliferation and apoptosis in cultured Schwann cells. J Neuroimmunol 124:29\u201335","journal-title":"J Neuroimmunol"},{"key":"344_CR127","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1046\/j.1365-2141.1997.2673084.x","volume":"98","author":"HG Drexler","year":"1997","unstructured":"Drexler HG, Zaborski M, Quentmeier H (1997) Interferon-gamma induced proliferation of human myeloid leukaemia cell lines. Br J Haematol 98:699\u2013710","journal-title":"Br J Haematol"},{"key":"344_CR128","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1182\/blood.V78.4.1085.1085","volume":"78","author":"I Murohashi","year":"1991","unstructured":"Murohashi I, Hoang T (1991) Interferon-gamma enhances growth factor-dependent proliferation of clonogenic cells in acute myeloblastic leukemia. Blood 78:1085\u20131095","journal-title":"Blood"},{"key":"344_CR129","first-page":"1145","volume":"13","author":"X Wu","year":"2010","unstructured":"Wu X, Xu K (2010) [Interleukin-1 and cancer]. Zhongguo Fei Ai Za Zhi 13:1145\u20131148","journal-title":"Zhongguo Fei Ai Za Zhi"},{"key":"344_CR130","doi-asserted-by":"publisher","first-page":"38","DOI":"10.2174\/138945009787122914","volume":"10","author":"Z Wang","year":"2009","unstructured":"Wang Z, Kong D, Li Y, Sarkar FH (2009) PDGF-D signaling: a novel target in cancer therapy. Curr Drug Targets 10:38\u201341","journal-title":"Curr Drug Targets"},{"key":"344_CR131","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/400_2008_26","volume":"49","author":"H Wajant","year":"2009","unstructured":"Wajant H (2009) The role of TNF in cancer. Results Probl Cell Differ 49:1\u201315","journal-title":"Results Probl Cell Differ"}],"container-title":["Topics in Current Chemistry","Natural Products in Cancer Prevention and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/128_2012_344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T23:44:03Z","timestamp":1714261443000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/128_2012_344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"ISBN":["9783642345746","9783642345753"],"references-count":131,"URL":"https:\/\/doi.org\/10.1007\/128_2012_344","relation":{},"ISSN":["0340-1022","1436-5049"],"issn-type":[{"value":"0340-1022","type":"print"},{"value":"1436-5049","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]},"assertion":[{"value":"1 August 2012","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}