{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:26:19Z","timestamp":1790832379261,"version":"4.1.0"},"publisher-location":"Cham","reference-count":110,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319563596","type":"print"},{"value":"9783319563602","type":"electronic"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/164_2016_107","type":"book-chapter","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T08:15:35Z","timestamp":1482135335000},"page":"193-217","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Abnormal Barrier Function in Gastrointestinal Disorders"],"prefix":"10.1007","author":[{"given":"Ricard","family":"Farr\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Vicario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2016,12,20]]},"reference":[{"key":"107_CR1","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.pain.2004.10.002","volume":"113","author":"A Ait-Belgnaoui","year":"2005","unstructured":"Ait-Belgnaoui A, Bradesi S, Fioramonti J, Theodorou V, Bueno L (2005) Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase. Pain 113:141\u2013147","journal-title":"Pain"},{"key":"107_CR2","doi-asserted-by":"publisher","first-page":"5653","DOI":"10.4049\/jimmunol.180.8.5653","volume":"180","author":"R Al-Sadi","year":"2008","unstructured":"Al-Sadi R, Ye D, Dokladny K, Ma TY (2008) Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. J Immunol 180:5653\u20135661","journal-title":"J Immunol"},{"key":"107_CR3","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1136\/gut.2008.150888","volume":"58","author":"MC Arrieta","year":"2009","unstructured":"Arrieta MC, Madsen K, Doyle J, Meddings J (2009) Reducing small intestinal permeability attenuates colitis in the IL10 gene-deficient mouse. Gut 58:41\u201348","journal-title":"Gut"},{"key":"107_CR4","doi-asserted-by":"crossref","unstructured":"Avila EE (2016) Functions of antimicrobial peptides in vertebrates. Curr Protein Pept Sci (Epub ahead of print)","DOI":"10.2174\/1389203717666160813162629"},{"issue":"6","key":"107_CR5","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.1053\/j.gastro.2016.02.012","volume":"150","author":"Q Aziz","year":"2016","unstructured":"Aziz Q, Fass R, Gyawali CP, Miwa H, Pandolfino JE, Zerbib F (2016) Functional esophageal disorders. Gastroenterology 150(6):1368\u20131379","journal-title":"Gastroenterology"},{"key":"107_CR6","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1113\/jphysiol.2006.120907","volume":"580","author":"F Barreau","year":"2007","unstructured":"Barreau F, Cartier C, Leveque M, Ferrier L, Moriez R, Laroute V, Rosztoczy A, Fioramonti J, Bueno L (2007) Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay. J Physiol 580:347\u2013356","journal-title":"J Physiol"},{"key":"107_CR7","doi-asserted-by":"publisher","first-page":"S160","DOI":"10.1016\/S0016-5085(13)60577-6","volume":"144","author":"S Basra","year":"2013","unstructured":"Basra S, Verne GN, Zhou QQ (2013) Randomized placebo-controlled trial of glutamine for the treatment of diarrhea-predominant IBS. Gastroenterology 144:S160\u2013S160","journal-title":"Gastroenterology"},{"key":"107_CR8","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.immuni.2012.08.024","volume":"37","author":"R Basu","year":"2012","unstructured":"Basu R, O\u2019Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT (2012) Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity 37:1061\u20131075","journal-title":"Immunity"},{"key":"107_CR9","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1016\/j.clnu.2013.01.014","volume":"32","author":"S Beutheu","year":"2013","unstructured":"Beutheu S, Ghouzali I, Galas L, Dechelotte P, Coeffier M (2013) Glutamine and arginine improve permeability and tight junction protein expression in methotrexate-treated Caco-2 cells. Clin Nutr 32:863\u2013869","journal-title":"Clin Nutr"},{"key":"107_CR10","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1038\/nrmicro2546","volume":"9","author":"CL Bevins","year":"2011","unstructured":"Bevins CL, Salzman NH (2011) Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol 9:356\u2013368","journal-title":"Nat Rev Microbiol"},{"key":"107_CR11","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1186\/s12876-014-0189-7","volume":"14","author":"SC Bischoff","year":"2014","unstructured":"Bischoff SC, Barbara G, Buurman W, Ockhuizen T, Schulzke JD, Serino M, Tilg H, Watson A, Wells JM (2014) Intestinal permeability \u2013 a new target for disease prevention and therapy. BMC Gastroenterol 14:189","journal-title":"BMC Gastroenterol"},{"key":"107_CR12","doi-asserted-by":"publisher","first-page":"349","DOI":"10.3390\/nu8060349","volume":"8","author":"MR Bono","year":"2016","unstructured":"Bono MR, Tejon G, Flores-Santibanez F, Fernandez D, Rosemblatt M, Sauma D (2016) Retinoic acid as a modulator of T cell immunity. Nutrients 8:349","journal-title":"Nutrients"},{"key":"107_CR13","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/mi.2007.9","volume":"1","author":"P Brandtzaeg","year":"2008","unstructured":"Brandtzaeg P, Kiyono H, Pabst R, Russell MW (2008) Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol 1:31\u201337","journal-title":"Mucosal Immunol"},{"key":"107_CR14","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrgastro.2014.103","volume":"11","author":"SM Brierley","year":"2014","unstructured":"Brierley SM, Linden DR (2014) Neuroplasticity and dysfunction after gastrointestinal inflammation. Nat Rev Gastroenterol Hepatol 11:611\u2013627","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"107_CR15","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0016-5085(24)05125-4","volume":"86","author":"WA Bye","year":"1984","unstructured":"Bye WA, Allan CH, Trier JS (1984) Structure, distribution, and origin of M cells in Peyer\u2019s patches of mouse ileum. Gastroenterology 86:789\u2013801","journal-title":"Gastroenterology"},{"key":"107_CR16","doi-asserted-by":"publisher","first-page":"G775","DOI":"10.1152\/ajpgi.00155.2012","volume":"303","author":"M Camilleri","year":"2012","unstructured":"Camilleri M, Lasch K, Zhou W (2012) Irritable bowel syndrome: methods, mechanisms, and pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome. Am J Physiol Gastrointest Liver Physiol 303:G775\u2013G785","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"107_CR17","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S1542-3565(04)00454-9","volume":"2","author":"EJ Castillo","year":"2004","unstructured":"Castillo EJ, Camilleri M, Locke GR, Burton DD, Stephens DA, Geno DM, Zinsmeister AR (2004) A community-based, controlled study of the epidemiology and pathophysiology of dyspepsia. Clin Gastroenterol Hepatol 2:985\u2013996","journal-title":"Clin Gastroenterol Hepatol"},{"key":"107_CR18","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1038\/nri2322","volume":"8","author":"A Cerutti","year":"2008","unstructured":"Cerutti A (2008) The regulation of IgA class switching. Nat Rev Immunol 8:421\u2013434","journal-title":"Nat Rev Immunol"},{"key":"107_CR19","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/nri3007","volume":"11","author":"H Cheroutre","year":"2011","unstructured":"Cheroutre H, Lambolez F, Mucida D (2011) The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol 11:445\u2013456","journal-title":"Nat Rev Immunol"},{"key":"107_CR20","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1136\/gut.52.2.224","volume":"52","author":"EC Clark","year":"2003","unstructured":"Clark EC, Patel SD, Chadwick PR, Warhurst G, Curry A, Carlson GL (2003) Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate. Gut 52:224\u2013230","journal-title":"Gut"},{"key":"107_CR21","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/ajg.2009.700","volume":"105","author":"M Coeffier","year":"2010","unstructured":"Coeffier M, Gloro R, Boukhettala N, Aziz M, Lecleire S, Vandaele N, Antonietti M, Savoye G, Bole-Feysot C, Dechelotte P, Reimund JM, Ducrotte P (2010) Increased proteasome-mediated degradation of occludin in irritable bowel syndrome. Am J Gastroenterol 105:1181\u20131188","journal-title":"Am J Gastroenterol"},{"key":"107_CR22","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/nri2335","volume":"8","author":"JL Coombes","year":"2008","unstructured":"Coombes JL, Powrie F (2008) Dendritic cells in intestinal immune regulation. Nat Rev Immunol 8:435\u2013446","journal-title":"Nat Rev Immunol"},{"key":"107_CR23","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2036.2009.04041.x","volume":"30","author":"R Corinaldesi","year":"2009","unstructured":"Corinaldesi R, Stanghellini V, Cremon C, Gargano L, Cogliandro RF, De Giorgio R, Bartesaghi G, Canovi B, Barbara G (2009) Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study. Aliment Pharmacol Ther 30:245\u2013252","journal-title":"Aliment Pharmacol Ther"},{"key":"107_CR24","doi-asserted-by":"publisher","first-page":"2989","DOI":"10.1113\/jphysiol.2014.273995","volume":"592","author":"G De Palma","year":"2014","unstructured":"De Palma G, Collins SM, Bercik P, Verdu EF (2014) The microbiota-gut-brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both? J Physiol 592:2989\u20132997","journal-title":"J Physiol"},{"key":"107_CR25","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1177\/014860719902300107","volume":"23","author":"E Den Hond","year":"1999","unstructured":"Den Hond E, Hiele M, Peeters M, Ghoos Y, Rutgeerts P (1999) Effect of long-term oral glutamine supplements on small intestinal permeability in patients with Crohn\u2019s disease. JPEN J Parenter Enteral Nutr 23:7\u201311","journal-title":"JPEN J Parenter Enteral Nutr"},{"issue":"6","key":"107_CR26","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1053\/j.gastro.2016.02.032","volume":"150","author":"DA Drossman","year":"2016","unstructured":"Drossman DA (2016) Functional gastrointestinal disorders: history, pathophysiology, clinical features and Rome IV. Gastroenterology 150(6):1262\u20131279","journal-title":"Gastroenterology"},{"key":"107_CR27","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1083\/jcb.17.2.375","volume":"17","author":"MG Farquhar","year":"1963","unstructured":"Farquhar MG, Palade GE (1963) Junctional complexes in various epithelia. J Cell Biol 17:375\u2013412","journal-title":"J Cell Biol"},{"key":"107_CR28","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1124\/jpet.105.094482","volume":"316","author":"R Farre","year":"2006","unstructured":"Farre R, Auli M, Lecea B, Martinez E, Clave P (2006) Pharmacologic characterization of intrinsic mechanisms controlling tone and relaxation of porcine lower esophageal sphincter. J Pharmacol Exp Ther 316:1238\u20131248","journal-title":"J Pharmacol Exp Ther"},{"key":"107_CR29","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1053\/j.gastro.2013.05.018","volume":"145","author":"R Farre","year":"2013","unstructured":"Farre R, Vanheel H, Vanuytsel T, Masaoka T, Tornblom H, Simren M, Van Oudenhove L, Tack JF (2013) In functional dyspepsia, hypersensitivity to postprandial distention correlates with meal-related symptom severity. Gastroenterology 145:566\u2013573","journal-title":"Gastroenterology"},{"key":"107_CR30","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1152\/physrev.00003.2008","volume":"91","author":"A Fasano","year":"2011","unstructured":"Fasano A (2011) Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiol Rev 91:151\u2013175","journal-title":"Physiol Rev"},{"key":"107_CR31","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1007\/s11095-007-9527-6","volume":"25","author":"LM Feighery","year":"2008","unstructured":"Feighery LM, Cochrane SW, Quinn T, Baird AW, O\u2019Toole D, Owens SE, O\u2019Donoghue D, Mrsny RJ, Brayden DJ (2008) Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro. Pharm Res 25:1377\u20131386","journal-title":"Pharm Res"},{"key":"107_CR32","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/nmo.12272","volume":"26","author":"J Fichna","year":"2014","unstructured":"Fichna J, Salaga M, Stuart J, Saur D, Sobczak M, Zatorski H, Timmermans JP, Bradshaw HB, Ahn K, Storr MA (2014) Selective inhibition of FAAH produces antidiarrheal and antinociceptive effect mediated by endocannabinoids and cannabinoid-like fatty acid amides. Neurogastroenterol Motil 26:470\u2013481","journal-title":"Neurogastroenterol Motil"},{"key":"107_CR33","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1177\/000992280604500205","volume":"45","author":"CA Friesen","year":"2006","unstructured":"Friesen CA, Sandridge L, Andre L, Roberts CC, Abdel-Rahman SM (2006) Mucosal eosinophilia and response to H1\/H2 antagonist and cromolyn therapy in pediatric dyspepsia. Clin Pediatr (Phila) 45:143\u2013147","journal-title":"Clin Pediatr (Phila)"},{"key":"107_CR34","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1038\/mi.2013.13","volume":"6","author":"M Fukata","year":"2013","unstructured":"Fukata M, Arditi M (2013) The role of pattern recognition receptors in intestinal inflammation. Mucosal Immunol 6:451\u2013463","journal-title":"Mucosal Immunol"},{"key":"107_CR35","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nature09646","volume":"469","author":"S Fukuda","year":"2011","unstructured":"Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469:543\u2013547","journal-title":"Nature"},{"key":"107_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0301-0082(97)00051-8","volume":"54","author":"JB Furness","year":"1998","unstructured":"Furness JB, Kunze WA, Bertrand PP, Clerc N, Bornstein JC (1998) Intrinsic primary afferent neurons of the intestine. Prog Neurobiol 54:1\u201318","journal-title":"Prog Neurobiol"},{"key":"107_CR37","doi-asserted-by":"publisher","first-page":"G522","DOI":"10.1152\/ajpgi.00510.2007","volume":"295","author":"D Gallego","year":"2008","unstructured":"Gallego D, Gil V, Aleu J, Auli M, Clave P, Jimenez M (2008) Purinergic and nitrergic junction potential in the human colon. Am J Physiol Gastrointest Liver Physiol 295:G522\u2013G533","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"107_CR38","doi-asserted-by":"publisher","first-page":"e983777","DOI":"10.4161\/21688370.2014.983777","volume":"3","author":"K Gerlach","year":"2015","unstructured":"Gerlach K, McKenzie AN, Neurath MF, Weigmann B (2015) IL-9 regulates intestinal barrier function in experimental T cell-mediated colitis. Tissue Barriers 3:e983777","journal-title":"Tissue Barriers"},{"key":"107_CR39","first-page":"G809","volume":"274","author":"M Goke","year":"1998","unstructured":"Goke M, Kanai M, Podolsky DK (1998) Intestinal fibroblasts regulate intestinal epithelial cell proliferation via hepatocyte growth factor. Am J Physiol 274:G809\u2013G818","journal-title":"Am J Physiol"},{"key":"107_CR40","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.peptides.2012.02.015","volume":"35","author":"S Gopalakrishnan","year":"2012","unstructured":"Gopalakrishnan S, Durai M, Kitchens K, Tamiz AP, Somerville R, Ginski M, Paterson BM, Murray JA, Verdu EF, Alkan SS, Pandey NB (2012) Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides 35:86\u201394","journal-title":"Peptides"},{"key":"107_CR41","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1152\/physrev.00019.2012","volume":"93","author":"D Gunzel","year":"2013","unstructured":"Gunzel D, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93:525\u2013569","journal-title":"Physiol Rev"},{"key":"107_CR42","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1016\/j.bbamem.2008.10.028","volume":"1788","author":"JA Guttman","year":"2009","unstructured":"Guttman JA, Finlay BB (2009) Tight junctions as targets of infectious agents. Biochim Biophys Acta 1788:832\u2013841","journal-title":"Biochim Biophys Acta"},{"key":"107_CR43","first-page":"209","volume":"37","author":"AM Hammer","year":"2015","unstructured":"Hammer AM, Morris NL, Earley ZM, Choudhry MA (2015) The first line of defense: the effects of alcohol on post-burn intestinal barrier, immune cells, and microbiome. Alcohol Res 37:209\u2013222","journal-title":"Alcohol Res"},{"issue":"3","key":"107_CR44","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1097\/SHK.0000000000000594","volume":"46","author":"B Han","year":"2016","unstructured":"Han B, Sheng B, Zhang Z, Pu A, Yin J, Wang Q, Yang K, Sun L, Yu M, Qiu Y, Xiao W, Yang H (2016) Aryl hydrocarbon receptor activation in intestinal obstruction ameliorates intestinal barrier dysfunction via suppression of MLCK-MLC phosphorylation pathway. Shock 46(3):319\u2013328","journal-title":"Shock"},{"key":"107_CR45","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1016\/j.bbamem.2007.07.012","volume":"1778","author":"A Hartsock","year":"2008","unstructured":"Hartsock A, Nelson WJ (2008) Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta 1778:660\u2013669","journal-title":"Biochim Biophys Acta"},{"key":"107_CR46","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1038\/nri2710","volume":"10","author":"LV Hooper","year":"2010","unstructured":"Hooper LV, Macpherson AJ (2010) Immune adaptations that maintain homeostasis with the intestinal microbiota. Nat Rev Immunol 10:159\u2013169","journal-title":"Nat Rev Immunol"},{"key":"107_CR47","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1038\/ajg.2011.102","volume":"106","author":"B Jovov","year":"2011","unstructured":"Jovov B, Que J, Tobey NA, Djukic Z, Hogan BL, Orlando RC (2011) Role of E-cadherin in the pathogenesis of gastroesophageal reflux disease. Am J Gastroenterol 106:1039\u20131047","journal-title":"Am J Gastroenterol"},{"key":"107_CR48","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/S0006-291X(03)00167-0","volume":"302","author":"G Kale","year":"2003","unstructured":"Kale G, Naren AP, Sheth P, Rao RK (2003) Tyrosine phosphorylation of occludin attenuates its interactions with ZO-1, ZO-2, and ZO-3. Biochem Biophys Res Commun 302:324\u2013329","journal-title":"Biochem Biophys Res Commun"},{"key":"107_CR49","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1111\/j.1365-2982.2010.01498.x","volume":"22","author":"AV Keita","year":"2010","unstructured":"Keita AV, Soderholm JD (2010) The intestinal barrier and its regulation by neuroimmune factors. Neurogastroenterol Motil 22:718\u2013733","journal-title":"Neurogastroenterol Motil"},{"key":"107_CR50","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1002\/path.2337","volume":"215","author":"AV Keita","year":"2008","unstructured":"Keita AV, Salim SY, Jiang T, Yang PC, Franzen L, Soderkvist P, Magnusson KE, Soderholm JD (2008) Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn\u2019s disease. J Pathol 215:135\u2013144","journal-title":"J Pathol"},{"key":"107_CR51","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1111\/apt.12147","volume":"37","author":"CP Kelly","year":"2013","unstructured":"Kelly CP, Green PH, Murray JA, Dimarino A, Colatrella A, Leffler DA, Alexander T, Arsenescu R, Leon F, Jiang JG, Arterburn LA, Paterson BM, Fedorak RN, Larazotide Acetate Celiac Disease Study G (2013) Larazotide acetate in patients with coeliac disease undergoing a gluten challenge: a randomised placebo-controlled study. Aliment Pharmacol Ther 37:252\u2013262","journal-title":"Aliment Pharmacol Ther"},{"key":"107_CR52","first-page":"392","volume":"9","author":"JR Kelly","year":"2015","unstructured":"Kelly JR, Kennedy PJ, Cryan JF, Dinan TG, Clarke G, Hyland NP (2015) Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Front Cell Neurosci 9:392","journal-title":"Front Cell Neurosci"},{"key":"107_CR53","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.chom.2010.06.006","volume":"8","author":"M Kim","year":"2010","unstructured":"Kim M, Ashida H, Ogawa M, Yoshikawa Y, Mimuro H, Sasakawa C (2010) Bacterial interactions with the host epithelium. Cell Host Microbe 8:20\u201335","journal-title":"Cell Host Microbe"},{"key":"107_CR54","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1136\/gut.2010.213108","volume":"59","author":"TK Klooker","year":"2010","unstructured":"Klooker TK, Braak B, Koopman KE, Welting O, Wouters MM, van der Heide S, Schemann M, Bischoff SC, van den Wijngaard RM, Boeckxstaens GE (2010) The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome. Gut 59:1213\u20131221","journal-title":"Gut"},{"key":"107_CR55","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1111\/j.1749-6632.2009.04025.x","volume":"1165","author":"S Koch","year":"2009","unstructured":"Koch S, Nusrat A (2009) Dynamic regulation of epithelial cell fate and barrier function by intercellular junctions. Ann N Y Acad Sci 1165:220\u2013227","journal-title":"Ann N Y Acad Sci"},{"key":"107_CR56","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1177\/0148607199023003136","volume":"23","author":"L Kouznetsova","year":"1999","unstructured":"Kouznetsova L, Bijlsma PB, van Leeuwen PA, Groot JA, Houdijk AP (1999) Glutamine reduces phorbol-12,13-dibutyrate-induced macromolecular hyperpermeability in HT-29Cl.19A intestinal cells. JPEN J Parenter Enteral Nutr 23:136\u2013139","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"107_CR57","doi-asserted-by":"publisher","first-page":"3713","DOI":"10.1091\/mbc.E09-01-0080","volume":"20","author":"SM Krug","year":"2009","unstructured":"Krug SM, Amasheh S, Richter JF, Milatz S, Gunzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009a) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell 20:3713\u20133724","journal-title":"Mol Biol Cell"},{"key":"107_CR58","doi-asserted-by":"publisher","first-page":"2202","DOI":"10.1016\/j.bpj.2009.08.003","volume":"97","author":"SM Krug","year":"2009","unstructured":"Krug SM, Fromm M, Gunzel D (2009b) Two-path impedance spectroscopy for measuring paracellular and transcellular epithelial resistance. Biophys J 97:2202\u20132211","journal-title":"Biophys J"},{"key":"107_CR59","doi-asserted-by":"publisher","first-page":"G128","DOI":"10.1152\/ajpgi.00459.2002","volume":"285","author":"O Le Bacquer","year":"2003","unstructured":"Le Bacquer O, Laboisse C, Darmaun D (2003) Glutamine preserves protein synthesis and paracellular permeability in Caco-2 cells submitted to \u201cluminal fasting\u201d. Am J Physiol Gastrointest Liver Physiol 285:G128\u2013G136","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"107_CR60","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1038\/ajg.2012.211","volume":"107","author":"DA Leffler","year":"2012","unstructured":"Leffler DA, Kelly CP, Abdallah HZ, Colatrella AM, Harris LA, Leon F, Arterburn LA, Paterson BM, Lan ZH, Murray JA (2012) A randomized, double-blind study of larazotide acetate to prevent the activation of celiac disease during gluten challenge. Am J Gastroenterol 107:1554\u20131562","journal-title":"Am J Gastroenterol"},{"key":"107_CR61","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1053\/j.gastro.2015.02.008","volume":"148","author":"DA Leffler","year":"2015","unstructured":"Leffler DA, Kelly CP, Green PH, Fedorak RN, DiMarino A, Perrow W, Rasmussen H, Wang C, Bercik P, Bachir NM, Murray JA (2015) Larazotide acetate for persistent symptoms of celiac disease despite a gluten-free diet: a randomized controlled trial. Gastroenterology 148:1311\u20131319 e1316","journal-title":"Gastroenterology"},{"key":"107_CR62","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00232-001-0103-4","volume":"184","author":"B Lindemann","year":"2001","unstructured":"Lindemann B (2001) Hans Ussing, experiments and models. J Membr Biol 184:203\u2013210","journal-title":"J Membr Biol"},{"key":"107_CR63","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/ni.3213","volume":"16","author":"C Lindner","year":"2015","unstructured":"Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Gaboriau-Routhiau V, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P, Pabst O (2015) Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nat Immunol 16:880\u2013888","journal-title":"Nat Immunol"},{"key":"107_CR64","doi-asserted-by":"publisher","first-page":"S494","DOI":"10.1016\/S0016-5085(15)31657-7","volume":"148","author":"B Lobo","year":"2015","unstructured":"Lobo B, Pigrau M, Martinez C, Gonzalez-Castro AM, Guilarte M, de Torres I, Salvo-Romero E, Rodino-Janeiro BK, Fortea M, Cotoner CA, Azpiroz F, Vicario M, Santos J (2015) Clinical benefit and intestinal mucosal transcriptome modulation after long-term mast cell stabilization with oral disodium cromoglycate in diarrhea-predominant irritable bowel syndrome (IBS-D) patients. Gastroenterology 148:S494\u2013S494","journal-title":"Gastroenterology"},{"key":"107_CR65","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1016\/j.cgh.2012.02.029","volume":"10","author":"RM Lovell","year":"2012","unstructured":"Lovell RM, Ford AC (2012) Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis. Clin Gastroenterol Hepatol 10:712\u2013721.e714","journal-title":"Clin Gastroenterol Hepatol"},{"key":"107_CR66","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1016\/j.bbamem.2008.11.005","volume":"1788","author":"TA Martin","year":"2009","unstructured":"Martin TA, Jiang WG (2009) Loss of tight junction barrier function and its role in cancer metastasis. Biochim Biophys Acta 1788:872\u2013891","journal-title":"Biochim Biophys Acta"},{"key":"107_CR67","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1038\/ajg.2011.472","volume":"107","author":"C Martinez","year":"2012","unstructured":"Martinez C, Vicario M, Ramos L, Lobo B, Mosquera JL, Alonso C, Sanchez A, Guilarte M, Antolin M, de Torres I, Gonzalez-Castro AM, Pigrau M, Saperas E, Azpiroz F, Santos J (2012) The jejunum of diarrhea-predominant irritable bowel syndrome shows molecular alterations in the tight junction signaling pathway that are associated with mucosal pathobiology and clinical manifestations. Am J Gastroenterol 107:736\u2013746","journal-title":"Am J Gastroenterol"},{"key":"107_CR68","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1136\/gutjnl-2012-302093","volume":"62","author":"C Martinez","year":"2013","unstructured":"Martinez C, Lobo B, Pigrau M, Ramos L, Gonzalez-Castro AM, Alonso C, Guilarte M, Guila M, de Torres I, Azpiroz F, Santos J, Vicario M (2013) Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier. Gut 62:1160\u20131168","journal-title":"Gut"},{"key":"107_CR69","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1186\/s12917-015-0588-1","volume":"11","author":"A Mereu","year":"2015","unstructured":"Mereu A, Tedo G, Moeser AJ, Rimbach G, Ipharraguerre IR (2015) Cromolyn-mediated improvement of intestinal barrier function is associated with enhanced piglet performance after weaning. BMC Vet Res 11:274","journal-title":"BMC Vet Res"},{"key":"107_CR70","doi-asserted-by":"publisher","first-page":"e73749","DOI":"10.1371\/journal.pone.0073749","volume":"8","author":"M Million","year":"2013","unstructured":"Million M, Zhao JF, Luckey A, Czimmer J, Maynard GD, Kehne J, Hoffman DC, Tache Y (2013) The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. PLoS One 8:e73749","journal-title":"PLoS One"},{"key":"107_CR71","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1186\/1471-230X-12-128","volume":"12","author":"K Monkemuller","year":"2012","unstructured":"Monkemuller K, Wex T, Kuester D, Fry LC, Kandulski A, Kropf S, Roessner A, Malfertheiner P (2012) Role of tight junction proteins in gastroesophageal reflux disease. BMC Gastroenterol 12:128","journal-title":"BMC Gastroenterol"},{"key":"107_CR72","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/S0002-9440(10)61196-0","volume":"167","author":"R Moriez","year":"2005","unstructured":"Moriez R, Salvador-Cartier C, Theodorou V, Fioramonti J, Eutamene H, Bueno L (2005) Myosin light chain kinase is involved in lipopolysaccharide-induced disruption of colonic epithelial barrier and bacterial translocation in rats. Am J Pathol 167:1071\u20131079","journal-title":"Am J Pathol"},{"key":"107_CR73","doi-asserted-by":"publisher","unstructured":"Morris G, Berk M, Carvalho A, Caso JR, Sanz Y, Walder K, Maes M (2016) The role of the microbial metabolites including tryptophan catabolites and short chain fatty acids in the patho-physiology of immune-inflammatory and neuroimmune disease. Mol Neurobiol. doi: 10.1007\/s12035-016-0004-2 (Epub ahead of print)","DOI":"10.1007\/s12035-016-0004-2"},{"key":"107_CR74","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1053\/j.gastro.2008.10.080","volume":"136","author":"AS Neish","year":"2009","unstructured":"Neish AS (2009) Microbes in gastrointestinal health and disease. Gastroenterology 136:65\u201380","journal-title":"Gastroenterology"},{"key":"107_CR75","doi-asserted-by":"publisher","first-page":"972","DOI":"10.1111\/j.1572-0241.1998.00290.x","volume":"93","author":"CM Noyer","year":"1998","unstructured":"Noyer CM, Simon D, Borczuk A, Brandt LJ, Lee MJ, Nehra V (1998) A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 93:972\u2013975","journal-title":"Am J Gastroenterol"},{"key":"107_CR76","doi-asserted-by":"publisher","first-page":"e11","DOI":"10.1111\/j.1365-2982.2010.01602.x","volume":"23","author":"A Opazo","year":"2011","unstructured":"Opazo A, Lecea B, Gil V, Jimenez M, Clave P, Gallego D (2011) Specific and complementary roles for nitric oxide and ATP in the inhibitory motor pathways to rat internal anal sphincter. Neurogastroenterol Motil 23:e11\u2013e25","journal-title":"Neurogastroenterol Motil"},{"key":"107_CR77","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1126\/science.1178334","volume":"327","author":"JJ O\u2019Shea","year":"2010","unstructured":"O\u2019Shea JJ, Paul WE (2010) Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells. Science 327:1098\u20131102","journal-title":"Science"},{"key":"107_CR78","doi-asserted-by":"publisher","first-page":"95","DOI":"10.15430\/JCP.2016.21.2.95","volume":"21","author":"MY Park","year":"2016","unstructured":"Park MY, Kim MY, Seo YR, Kim JS, Sung MK (2016) High-fat diet accelerates intestinal tumorigenesis through disrupting intestinal cell membrane integrity. J Cancer Prev 21:95\u2013103","journal-title":"J Cancer Prev"},{"key":"107_CR79","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/S0210-5705(01)70167-7","volume":"24","author":"S Pascual","year":"2001","unstructured":"Pascual S, Martinez J, Perez-Mateo M (2001) The intestinal barrier: functional disorders in digestive and non-digestive diseases. Gastroenterol Hepatol 24:256\u2013267","journal-title":"Gastroenterol Hepatol"},{"key":"107_CR80","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.burns.2003.09.032","volume":"30","author":"X Peng","year":"2004","unstructured":"Peng X, Yan H, You Z, Wang P, Wang S (2004) Effects of enteral supplementation with glutamine granules on intestinal mucosal barrier function in severe burned patients. Burns 30:135\u2013139","journal-title":"Burns"},{"key":"107_CR81","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/gut.2007.140806","volume":"58","author":"T Piche","year":"2009","unstructured":"Piche T, Barbara G, Aubert P, Bruley des Varannes S, Dainese R, Nano JL, Cremon C, Stanghellini V, De Giorgio R, Galmiche JP, Neunlist M (2009) Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators. Gut 58:196\u2013201","journal-title":"Gut"},{"key":"107_CR82","doi-asserted-by":"publisher","first-page":"33","DOI":"10.5056\/jnm14084","volume":"21","author":"BK Rodino-Janeiro","year":"2015","unstructured":"Rodino-Janeiro BK, Alonso-Cotoner C, Pigrau M, Lobo B, Vicario M, Santos J (2015) Role of corticotropin-releasing factor in gastrointestinal permeability. J Neurogastroenterol Motil 21:33\u201350","journal-title":"J Neurogastroenterol Motil"},{"key":"107_CR83","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1083\/jcb.141.2.397","volume":"141","author":"M Saitou","year":"1998","unstructured":"Saitou M, Fujimoto K, Doi Y, Itoh M, Fujimoto T, Furuse M, Takano H, Noda T, Tsukita S (1998) Occludin-deficient embryonic stem cells can differentiate into polarized epithelial cells bearing tight junctions. J Cell Biol 141:397\u2013408","journal-title":"J Cell Biol"},{"key":"107_CR84","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/MOG.0b013e3283506559","volume":"28","author":"R Santaolalla","year":"2012","unstructured":"Santaolalla R, Abreu MT (2012) Innate immunity in the small intestine. Curr Opin Gastroenterol 28:124\u2013129","journal-title":"Curr Opin Gastroenterol"},{"key":"107_CR85","doi-asserted-by":"publisher","first-page":"2383","DOI":"10.1053\/j.gastro.2007.02.052","volume":"132","author":"BT Schwarz","year":"2007","unstructured":"Schwarz BT, Wang F, Shen L, Clayburgh DR, Su L, Wang Y, Fu YX, Turner JR (2007) LIGHT signals directly to intestinal epithelia to cause barrier dysfunction via cytoskeletal and endocytic mechanisms. Gastroenterology 132:2383\u20132394","journal-title":"Gastroenterology"},{"key":"107_CR86","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.cbi.2010.08.007","volume":"188","author":"T Sergent","year":"2010","unstructured":"Sergent T, Piront N, Meurice J, Toussaint O, Schneider YJ (2010) Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact 188:659\u2013667","journal-title":"Chem Biol Interact"},{"key":"107_CR87","doi-asserted-by":"publisher","first-page":"1916","DOI":"10.1091\/mbc.E08-10-1014","volume":"20","author":"EA Severson","year":"2009","unstructured":"Severson EA, Lee WY, Capaldo CT, Nusrat A, Parkos CA (2009) Junctional adhesion molecule A interacts with Afadin and PDZ-GEF2 to activate Rap1A, regulate beta1 integrin levels, and enhance cell migration. Mol Biol Cell 20:1916\u20131925","journal-title":"Mol Biol Cell"},{"key":"107_CR88","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1126\/science.1237910","volume":"342","author":"M Shan","year":"2013","unstructured":"Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A (2013) Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342:447\u2013453","journal-title":"Science"},{"key":"107_CR89","doi-asserted-by":"publisher","first-page":"G577","DOI":"10.1152\/ajpgi.00439.2005","volume":"290","author":"L Shen","year":"2006","unstructured":"Shen L, Turner JR (2006) Role of epithelial cells in initiation and propagation of intestinal inflammation. Eliminating the static: tight junction dynamics exposed. Am J Physiol Gastrointest Liver Physiol 290:G577\u2013G582","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"107_CR90","doi-asserted-by":"publisher","first-page":"324","DOI":"10.5056\/jnm.2012.18.3.324","volume":"18","author":"P Singh","year":"2012","unstructured":"Singh P, Agnihotri A, Pathak MK, Shirazi A, Tiwari RP, Sreenivas V, Sagar R, Makharia GK (2012) Psychiatric, somatic and other functional gastrointestinal disorders in patients with irritable bowel syndrome at a tertiary care center. J Neurogastroenterol Motil 18:324\u2013331","journal-title":"J Neurogastroenterol Motil"},{"key":"107_CR91","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1038\/nri1810","volume":"6","author":"EM Sternberg","year":"2006","unstructured":"Sternberg EM (2006) Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 6:318\u2013328","journal-title":"Nat Rev Immunol"},{"key":"107_CR92","doi-asserted-by":"publisher","first-page":"965","DOI":"10.3945\/jn.108.100867","volume":"139","author":"T Suzuki","year":"2009","unstructured":"Suzuki T, Hara H (2009) Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr 139:965\u2013974","journal-title":"J Nutr"},{"key":"107_CR93","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1136\/gutjnl-2014-308419","volume":"64","author":"H Tanaka","year":"2015","unstructured":"Tanaka H, Takechi M, Kiyonari H, Shioi G, Tamura A, Tsukita S (2015) Intestinal deletion of Claudin-7 enhances paracellular organic solute flux and initiates colonic inflammation in mice. Gut 64:1529\u20131538","journal-title":"Gut"},{"key":"107_CR94","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/sj.bjp.0702977","volume":"129","author":"M Tonini","year":"2000","unstructured":"Tonini M, De Giorgio R, De Ponti F, Sternini C, Spelta V, Dionigi P, Barbara G, Stanghellini V, Corinaldesi R (2000) Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations. Br J Pharmacol 129:12\u201320","journal-title":"Br J Pharmacol"},{"key":"107_CR95","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1038\/nri2653","volume":"9","author":"JR Turner","year":"2009","unstructured":"Turner JR (2009) Intestinal mucosal barrier function in health and disease. Nat Rev Immunol 9:799\u2013809","journal-title":"Nat Rev Immunol"},{"key":"107_CR96","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1111\/j.1572-0241.2006.00630.x","volume":"101","author":"N Vakil","year":"2006","unstructured":"Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R, Global Consensus G (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence-based consensus. Am J Gastroenterol 101:1900\u20131920 (quiz 1943)","journal-title":"Am J Gastroenterol"},{"key":"107_CR97","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1146\/annurev.physiol.010908.163145","volume":"71","author":"LG Flier van der","year":"2009","unstructured":"van der Flier LG, Clevers H (2009) Stem cells, self-renewal, and differentiation in the intestinal epithelium. Annu Rev Physiol 71:241\u2013260","journal-title":"Annu Rev Physiol"},{"key":"107_CR98","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/nrgastro.2012.255","volume":"10","author":"H Vanheel","year":"2013","unstructured":"Vanheel H, Farre R (2013) Changes in gastrointestinal tract function and structure in functional dyspepsia. Nat Rev Gastroenterol Hepatol 10:142\u2013149","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"107_CR99","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/gutjnl-2012-303857","volume":"63","author":"H Vanheel","year":"2014","unstructured":"Vanheel H, Vicario M, Vanuytsel T, Van Oudenhove L, Martinez C, Keita AV, Pardon N, Santos J, Soderholm JD, Tack J, Farre R (2014) Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut 63:262\u2013271","journal-title":"Gut"},{"key":"107_CR100","doi-asserted-by":"publisher","first-page":"S49","DOI":"10.1016\/S0016-5085(15)30171-2","volume":"148","author":"H Vanheel","year":"2015","unstructured":"Vanheel H, Vicario M, Vanuytsel T, Tack JF, Farre R (2015) Eosinophils and mast cells in functional dyspepsia: ultrastructural evaluation of activation. Gastroenterology 148:S49","journal-title":"Gastroenterology"},{"key":"107_CR101","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1136\/gutjnl-2013-305690","volume":"63","author":"T Vanuytsel","year":"2014","unstructured":"Vanuytsel T, van Wanrooy S, Vanheel H, Vanormelingen C, Verschueren S, Houben E, Salim Rasoel S, Tomicronth J, Holvoet L, Farre R, Van Oudenhove L, Boeckxstaens G, Verbeke K, Tack J (2014a) Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism. Gut 63:1293\u20131299","journal-title":"Gut"},{"key":"107_CR102","doi-asserted-by":"publisher","first-page":"e111132","DOI":"10.1371\/journal.pone.0111132","volume":"9","author":"T Vanuytsel","year":"2014","unstructured":"Vanuytsel T, Vanormelingen C, Vanheel H, Masaoka T, Salim Rasoel S, Toth J, Houben E, Verbeke K, De Hertogh G, Vanden Berghe P, Tack J, Farre R (2014b) From intestinal permeability to dysmotility: the biobreeding rat as a model for functional gastrointestinal disorders. PLoS One 9:e111132","journal-title":"PLoS One"},{"key":"107_CR103","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1136\/gutjnl-2013-306236","volume":"64","author":"M Vicario","year":"2015","unstructured":"Vicario M, Gonzalez-Castro AM, Martinez C, Lobo B, Pigrau M, Guilarte M, de Torres I, Mosquera JL, Fortea M, Sevillano-Aguilera C, Salvo-Romero E, Alonso C, Rodino-Janeiro BK, Soderholm JD, Azpiroz F, Santos J (2015) Increased humoral immunity in the jejunum of diarrhoea-predominant irritable bowel syndrome associated with clinical manifestations. Gut 64:1379\u20131388","journal-title":"Gut"},{"key":"107_CR104","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1136\/gut.2006.117549","volume":"57","author":"C Wallon","year":"2008","unstructured":"Wallon C, Yang PC, Keita AV, Ericson AC, McKay DM, Sherman PM, Perdue MH, Soderholm JD (2008) Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro. Gut 57:50\u201358","journal-title":"Gut"},{"key":"107_CR105","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3945\/jn.115.224857","volume":"146","author":"B Wang","year":"2016","unstructured":"Wang B, Wu Z, Ji Y, Sun K, Dai Z, Wu G (2016) L-glutamine enhances tight junction integrity by activating CaMK kinase 2-AMP-activated protein kinase signaling in intestinal porcine epithelial cells. J Nutr 146:501\u2013508","journal-title":"J Nutr"},{"key":"107_CR106","doi-asserted-by":"publisher","first-page":"5221","DOI":"10.1242\/jcs.02630","volume":"118","author":"CJ Watson","year":"2005","unstructured":"Watson CJ, Hoare CJ, Garrod DR, Carlson GL, Warhurst G (2005) Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores. J Cell Sci 118:5221\u20135230","journal-title":"J Cell Sci"},{"key":"107_CR107","doi-asserted-by":"publisher","first-page":"12037","DOI":"10.1074\/jbc.M109.064808","volume":"285","author":"CR Weber","year":"2010","unstructured":"Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR (2010) Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem 285:12037\u201312046","journal-title":"J Biol Chem"},{"key":"107_CR108","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1365-2559.2011.04123.x","volume":"60","author":"T Wex","year":"2012","unstructured":"Wex T, Monkemuller K, Stahr A, Kuester D, Fry LC, Volkel S, Kandulski A, Roessner A, Malfertheiner P (2012) Gastro-oesophageal reflux disease is associated with up-regulation of desmosomal components in oesophageal mucosa. Histopathology 60:405\u2013415","journal-title":"Histopathology"},{"key":"107_CR109","doi-asserted-by":"publisher","first-page":"2260","DOI":"10.1016\/j.ajpath.2014.05.003","volume":"184","author":"LL Wu","year":"2014","unstructured":"Wu LL, Peng WH, Kuo WT, Huang CY, Ni YH, Lu KS, Turner JR, Yu LC (2014) Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-gamma. Am J Pathol 184:2260\u20132274","journal-title":"Am J Pathol"},{"key":"107_CR110","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1136\/gut.2006.094375","volume":"56","author":"S Zeissig","year":"2007","unstructured":"Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn\u2019s disease. Gut 56:61\u201372","journal-title":"Gut"}],"container-title":["Handbook of Experimental Pharmacology","Gastrointestinal Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2016_107","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T18:44:45Z","timestamp":1749840285000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/164_2016_107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319563596","9783319563602"],"references-count":110,"URL":"https:\/\/doi.org\/10.1007\/164_2016_107","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"20 December 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}