{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T22:49:46Z","timestamp":1743029386652,"version":"3.40.3"},"publisher-location":"Cham","reference-count":149,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783319582887"},{"type":"electronic","value":"9783319582900"}],"license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016]]},"DOI":"10.1007\/164_2016_23","type":"book-chapter","created":{"date-parts":[[2016,11,4]],"date-time":"2016-11-04T05:17:13Z","timestamp":1478236633000},"page":"137-161","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Keratoconus and Other Corneal Diseases: Pharmacologic Cross-Linking and Future Therapy"],"prefix":"10.1007","author":[{"given":"Kimberly M.","family":"Hsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel","family":"Sugar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,11,5]]},"reference":[{"issue":"1","key":"23_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1869-5760-3-47","volume":"3","author":"J Alio","year":"2013","unstructured":"Alio J, Abbouda A, Valle DD, Del Castillo JB, Fernandez JG (2013) Corneal cross linking and infectious keratitis: a systematic review with a meta-analysis of reported cases. J Ophthalmic Inflamm Infect 3(1):47","journal-title":"J Ophthalmic Inflamm Infect"},{"issue":"12","key":"23_CR2","doi-asserted-by":"publisher","first-page":"2413","DOI":"10.1016\/j.ophtha.2013.07.038","volume":"120","author":"R Arora","year":"2013","unstructured":"Arora R, Manudhane A, Saran RK, Goyal J, Goyal G, Gupta D (2013) Role of corneal collagen cross-linking in pseudophakic bullous keratopathy: a clinicopathological study. Ophthalmology 120(12):2413\u20132418","journal-title":"Ophthalmology"},{"issue":"8","key":"23_CR3","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1136\/bjo.2009.164228","volume":"94","author":"PT Ashwin","year":"2010","unstructured":"Ashwin PT, McDonnell PJ (2010) Collagen cross-linkage: a comprehensive review and directions for future research. Br J Ophthalmol 94(8):965\u2013970","journal-title":"Br J Ophthalmol"},{"issue":"12","key":"23_CR4","doi-asserted-by":"publisher","first-page":"2137","DOI":"10.1016\/j.jcrs.2011.08.026","volume":"37","author":"D Asri","year":"2011","unstructured":"Asri D, Touboul D, Fourni\u00e9 P, Malet F, Garra C, Gallois A, Malecaze F, Colin J (2011) Corneal collagen crosslinking in progressive keratoconus: multicenter results from the French National Reference Center for Keratoconus. J Cataract Refract Surg 37(12):2137\u20132143","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"23_CR5","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.jcrs.2009.11.003","volume":"36","author":"M Avila","year":"2010","unstructured":"Avila M, Navia J (2010) Effect of genipin collagen crosslinking on porcine corneas. J Cataract Refract Surg 36(4):659\u2013664","journal-title":"J Cataract Refract Surg"},{"key":"23_CR6","first-page":"1068","volume":"18","author":"M Avila","year":"2012","unstructured":"Avila M, Gerena V, Navia J (2012) Corneal crosslinking with genipin, comparison with UV-riboflavin in ex-vivo model. Mol Vis 18:1068\u20131073","journal-title":"Mol Vis"},{"issue":"6","key":"23_CR7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/ICL.0000000000000091","volume":"40","author":"N Avni-Zauberman","year":"2014","unstructured":"Avni-Zauberman N, Rootman D (2014) Crosslinking and intracorneal ring segments-review of the literature. Eye Contact Lens 40(6):365\u2013370","journal-title":"Eye Contact Lens"},{"issue":"10","key":"23_CR8","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1097\/ICO.0b013e31823cbeb1","volume":"31","author":"B Bagga","year":"2012","unstructured":"Bagga B, Pahuja S, Murthy S, Sangwan V (2012) Endothelial failure after collagen cross-linking with riboflavin and UV-A: case report with literature review. Cornea 31(10):1197\u20131200","journal-title":"Cornea"},{"issue":"2","key":"23_CR9","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1097\/ICO.0b013e31825cea99","volume":"32","author":"M Berra","year":"2013","unstructured":"Berra M, Galper\u00edn G, Boscaro G, Zarate J, Tau J, Chiaradia P, Berra A (2013) Treatment of Acanthamoeba keratitis by corneal cross-linking. Cornea 32(2):174\u2013178","journal-title":"Cornea"},{"issue":"11","key":"23_CR10","doi-asserted-by":"publisher","first-page":"798","DOI":"10.3928\/1081597X-20121011-09","volume":"28","author":"D Bettis","year":"2012","unstructured":"Bettis D, Hsu M, Moshirfar M (2012) Corneal collagen cross-linking for nonectatic disorders: a systematic review. J Refract Surg 28(11):798\u2013807","journal-title":"J Refract Surg"},{"issue":"1","key":"23_CR11","doi-asserted-by":"publisher","first-page":"e30","DOI":"10.1111\/aos.12235","volume":"92","author":"G Bikbova","year":"2014","unstructured":"Bikbova G, Bikbov M (2014) Transepithelial corneal collagen cross-linking by iontophoresis of riboflavin. Acta Ophthalmol 92(1):e30\u2013e34","journal-title":"Acta Ophthalmol"},{"issue":"6","key":"23_CR12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066408","volume":"8","author":"K Bottos","year":"2013","unstructured":"Bottos K, Oliveira A, Bersanetti P, Nogueira R, Lima-Filho A, Cardillo J, Schor P, Chamon W (2013) Corneal absorption of a new riboflavin-nanostructured system for transepithelial collagen cross-linking. PLoS One 8(6), e66408","journal-title":"PLoS One"},{"key":"23_CR13","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1098\/rspl.1862.0069","volume":"12","author":"RW Bunsen","year":"1862","unstructured":"Bunsen RW, Roscoe HE (1862) Photochemical researches.--Part V. On the measurement of the chemical action of direct and diffuse sunlight. Proc R Soc Lond 12:306\u2013312","journal-title":"Proc R Soc Lond"},{"issue":"4","key":"23_CR14","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.ajo.2009.10.021","volume":"149","author":"A Caporossi","year":"2010","unstructured":"Caporossi A, Mazzotta C, Baiocchi S, Caporossi T (2010) Long-term results of riboflavin ultraviolet A corneal collagen cross-linking for keratoconus in Italy: the Siena eye cross study. Am J Ophthalmol 149(4):585\u2013593","journal-title":"Am J Ophthalmol"},{"key":"23_CR15","doi-asserted-by":"crossref","unstructured":"Chai D, Juhasz T, Brown D, Jester J (2013) Nonlinear optical collagen cross-linking and mechanical stiffening: a possible photodynamic therapeutic approach to treating corneal ectasia. J Biomed Opt 18(3)","DOI":"10.1117\/1.JBO.18.3.038003"},{"issue":"5-6","key":"23_CR16","doi-asserted-by":"publisher","first-page":"275","DOI":"10.3109\/08820538.2013.825295","volume":"28","author":"H-Y Chang","year":"2013","unstructured":"Chang H-Y, Chodosh J (2013) The genetics of keratoconus. Semin Ophthalmol 28(5-6):275\u2013280","journal-title":"Semin Ophthalmol"},{"issue":"4","key":"23_CR17","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/ICU.0b013e3283543cbd","volume":"23","author":"A Cheema","year":"2012","unstructured":"Cheema A, Mozayan A, Channa P (2012) Corneal collagen crosslinking in refractive surgery. Curr Opin Ophthalmol 23(4):251\u2013256","journal-title":"Curr Opin Ophthalmol"},{"issue":"5","key":"23_CR18","doi-asserted-by":"publisher","first-page":"3426","DOI":"10.1167\/iovs.12-11509","volume":"54","author":"D Cherfan","year":"2013","unstructured":"Cherfan D, Verter E, Melki S, Gisel T, Doyle F, Scarcelli G, Yun S, Redmond R, Kochevar I (2013) Collagen cross-linking using rose bengal and green light to increase corneal stiffness. Invest Ophthalmol Vis Sci 54(5):3426\u20133433","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"23_CR19","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1097\/ICO.0b013e3181c296c2","volume":"29","author":"M Cordeiro Barbosa","year":"2010","unstructured":"Cordeiro Barbosa M, Barbosa JB, Hirai F, Hofling-Lima AL (2010) Effect of cross-linking on corneal thickness in patients with corneal edema. Cornea 29(6):613\u2013617","journal-title":"Cornea"},{"issue":"10","key":"23_CR20","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1097\/ICO.0b013e3181d2c644","volume":"29","author":"A Daxer","year":"2010","unstructured":"Daxer A, Mahmoud H, Venkateswaran RS (2010) Corneal crosslinking and visual rehabilitation in keratoconus in one session without epithelial debridement: new technique. Cornea 29(10):1176\u20131179","journal-title":"Cornea"},{"issue":"3","key":"23_CR21","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/j.ajo.2011.07.025","volume":"153","author":"M Buey del","year":"2012","unstructured":"del Buey M, Crist\u00f3bal J, Casas P, Go\u00f1i P, Clavel A, M\u00ednguez E, Lanchares E, Garc\u00eda A, Calvo B (2012) Evaluation of in vitro efficacy of combined riboflavin and ultraviolet a for Acanthamoeba isolates. Am J Ophthalmol 153(3):399\u2013404","journal-title":"Am J Ophthalmol"},{"key":"23_CR22","doi-asserted-by":"publisher","first-page":"608253","DOI":"10.1155\/2013\/608253","volume":"2013","author":"G Demirci","year":"2013","unstructured":"Demirci G, Ozdamar A (2013) A case of medication-resistant acanthamoeba keratitis treated by corneal crosslinking in Turkey. Case Rep Ophthalmol Med 2013:608253. doi: 10.1155\/2013\/608253 , Epub 2013 Dec 22","journal-title":"Case Rep Ophthalmol Med"},{"key":"23_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2011\/869015","volume":"2011","author":"S Dhawan","year":"2011","unstructured":"Dhawan S, Rao K, Natrajan S (2011) Complications of corneal collagen cross-linking. J Ophthalmol 2011:1\u20135","journal-title":"J Ophthalmol"},{"key":"23_CR24","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.exer.2012.09.005","volume":"104","author":"L Dudakova","year":"2012","unstructured":"Dudakova L, Liskova P, Trojek T, Palos M, Kalasova S, Jirsova K (2012) Changes in lysyl oxidase (LOX) distribution and its decreased activity in keratoconus corneas. Exp Eye Res 104:74\u201381","journal-title":"Exp Eye Res"},{"key":"23_CR25","doi-asserted-by":"publisher","first-page":"18S","DOI":"10.1097\/PRS.0b013e31825efea6","volume":"130","author":"R Dunn","year":"2012","unstructured":"Dunn R (2012) Cross-linking in biomaterials. Plast Reconstr Surg 130:18S\u201326S","journal-title":"Plast Reconstr Surg"},{"issue":"8","key":"23_CR26","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1097\/ICO.0000000000000154","volume":"33","author":"U Elbaz","year":"2014","unstructured":"Elbaz U, Shen C, Lichtinger A, Zauberman N, Goldich Y, Chan C, Slomovic A, Rootman D (2014) Accelerated (9-mW\/cm2) corneal collagen crosslinking for keratoconus-A 1-year follow-up. Cornea 33(8):769\u2013773","journal-title":"Cornea"},{"issue":"1","key":"23_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/02713680601077145","volume":"32","author":"A Elsheikh","year":"2007","unstructured":"Elsheikh A, Wang D, Brown M, Rama P, Campanelli M, Pye D (2007) Assessment of corneal biomechanical properties and their variation with age. Curr Eye Res 32(1):11\u201319","journal-title":"Curr Eye Res"},{"key":"23_CR28","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/B978-0-323-06387-6.00081-7","volume-title":"Cornea","author":"R Feder","year":"2011","unstructured":"Feder R, Gan T (2011) Noninflammatory ectatic disorders. In: Krachmer J, Mannis M, Holland E (eds) Cornea. Mosby, Philadelphia, pp 865\u2013887"},{"issue":"2","key":"23_CR29","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/j.jcrs.2011.08.030","volume":"38","author":"M Filippello","year":"2012","unstructured":"Filippello M, Stagni E, O\u2019Brart D (2012) Transepithelial corneal collagen crosslinking: bilateral study. J Cataract Refract Surg 38(2):283\u2013291","journal-title":"J Cataract Refract Surg"},{"issue":"Pt 4","key":"23_CR30","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/eye.1997.127","volume":"11","author":"TJ Freegard","year":"1997","unstructured":"Freegard TJ (1997) The physical basis of transparency of the normal cornea. Eye (Lond) 11(Pt 4):465\u2013471","journal-title":"Eye (Lond)"},{"issue":"2","key":"23_CR31","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1097\/ICO.0b013e318221cec7","volume":"31","author":"G Galperin","year":"2012","unstructured":"Galperin G, Berra M, Tau J, Boscaro G, Zarate J, Berra A (2012) Treatment of fungal keratitis from Fusarium infection by corneal cross-linking. Cornea 31(2):176\u2013180","journal-title":"Cornea"},{"issue":"12","key":"23_CR32","doi-asserted-by":"publisher","first-page":"994","DOI":"10.3928\/1081597X-20100804-02","volume":"26","author":"S Garcia-Delpech","year":"2010","unstructured":"Garcia-Delpech S, D\u00edaz-Llopis M, Udaondo P, Salom D (2010) Fusarium keratitis 3 weeks after healed corneal cross-linking. J Refract Surg 26(12):994\u2013995","journal-title":"J Refract Surg"},{"issue":"12","key":"23_CR33","doi-asserted-by":"publisher","first-page":"846","DOI":"10.3928\/1081597X-20131023-03","volume":"29","author":"Z Gatzioufas","year":"2013","unstructured":"Gatzioufas Z, Richoz O, Brugnoli E, Hafezi F (2013) Safety profile of high-fluence corneal collagen cross-linking for progressive keratoconus: preliminary results from a prospective cohort study. J Refract Surg 29(12):846\u2013848","journal-title":"J Refract Surg"},{"key":"23_CR34","doi-asserted-by":"crossref","unstructured":"Gautam, Jhanji V, Satpathy G, Khokhar S, Agarwal T (2013) Microsporidial keratitis after collagen cross-linking. Ocul Immunol Inflamm 21(6):495\u2013497","DOI":"10.3109\/09273948.2013.824105"},{"issue":"2","key":"23_CR35","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.jcrs.2009.07.041","volume":"36","author":"R Ghanem","year":"2010","unstructured":"Ghanem R, Santhiago M, Berti T, Thomaz S, Netto M (2010) Collagen crosslinking with riboflavin and ultraviolet-A in eyes with pseudophakic bullous keratopathy. J Cataract Refract Surg 36(2):273\u2013276","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"23_CR36","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1097\/ICO.0b013e318226bf4a","volume":"31","author":"Y Goldich","year":"2012","unstructured":"Goldich Y, Marcovich A, Barkana Y, Mandel Y, Hirsh A, Morad Y, Avni I, Zadok D (2012) Clinical and corneal biomechanical changes after collagen cross-linking with riboflavin and UV irradiation in patients with progressive keratoconus: results after 2 years of follow-up. Cornea 31(6):609\u2013614","journal-title":"Cornea"},{"issue":"12","key":"23_CR37","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.1016\/j.jcrs.2010.06.067","volume":"36","author":"S Greenstein","year":"2010","unstructured":"Greenstein S, Fry K, Bhatt J, Hersh P (2010) Natural history of corneal haze after collagen crosslinking for keratoconus and corneal ectasia: scheimpflug and biomicroscopic analysis. J Cataract Refract Surg 36(12):2105\u20132114","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"23_CR38","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1097\/ICO.0b013e31820143d1","volume":"30","author":"F Hafezi","year":"2011","unstructured":"Hafezi F (2011) Limitation of collagen cross-linking with hypoosmolar riboflavin solution: failure in an extremely thin cornea. Cornea 30(8):917\u2013919","journal-title":"Cornea"},{"issue":"4","key":"23_CR39","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1016\/j.jcrs.2008.10.060","volume":"35","author":"F Hafezi","year":"2009","unstructured":"Hafezi F, Mrochen M, Iseli HP, Seiler T (2009) Collagen crosslinking with ultraviolet-A and hypoosmolar riboflavin solution in thin corneas. J Cataract Refract Surg 35(4):621\u2013624","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"23_CR40","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1002\/jbm.a.10460","volume":"65","author":"B Han","year":"2003","unstructured":"Han B, Jaurequi J, Tang BW, Nimni M (2003) Proanthocyanidin: a natural crosslinking reagent for stabilizing collagen matrices. J Biomed Mater Res A 65(1):118\u2013124","journal-title":"J Biomed Mater Res A"},{"issue":"3","key":"23_CR41","doi-asserted-by":"publisher","first-page":"367","DOI":"10.4103\/0301-4738.109523","volume":"62","author":"Z Hassan","year":"2014","unstructured":"Hassan Z, Nemeth G, Modis L, Szalai E, Berta A (2014) Collagen cross-linking in the treatment of pellucid marginal degeneration. Indian J Ophthalmol 62(3):367\u2013370","journal-title":"Indian J Ophthalmol"},{"issue":"1","key":"23_CR42","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.jcrs.2010.07.030","volume":"37","author":"P Hersh","year":"2011","unstructured":"Hersh P, Greenstein S, Fry K (2011) Corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 37(1):149\u2013160","journal-title":"J Cataract Refract Surg"},{"issue":"13","key":"23_CR43","doi-asserted-by":"publisher","first-page":"7307","DOI":"10.1073\/pnas.111150598","volume":"98","author":"D Holmes","year":"2001","unstructured":"Holmes D, Gilpin C, Baldock C, Ziese U, Koster A, Kadler K (2001) Corneal collagen fibril structure in three dimensions: structural insights into fibril assembly, mechanical properties, and tissue organization. Proc Natl Acad Sci 98(13):7307\u20137312","journal-title":"Proc Natl Acad Sci"},{"issue":"4","key":"23_CR44","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.ajo.2011.03.023","volume":"152","author":"J Holopainen","year":"2011","unstructured":"Holopainen J, Krootila K (2011) Transient corneal thinning in eyes undergoing corneal cross-linking. Am J Ophthalmol 152(4):533\u2013536","journal-title":"Am J Ophthalmol"},{"key":"23_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2012\/406850","volume":"2012","author":"M Hovakimyan","year":"2012","unstructured":"Hovakimyan M, Guthoff R, Stachs O (2012) Collagen cross-linking: current status and future directions. J Ophthalmol 2012:1\u201312","journal-title":"J Ophthalmol"},{"issue":"6","key":"23_CR46","doi-asserted-by":"publisher","first-page":"366","DOI":"10.3928\/1081597X-20140523-01","volume":"30","author":"S Jacob","year":"2014","unstructured":"Jacob S, Kumar DA, Agarwal A, Basu S, Sinha P, Agarwal A (2014) Contact lens-assisted collagen cross-linking (CACXL): a new technique for cross-linking thin corneas. J Refract Surg 30(6):366\u2013372","journal-title":"J Refract Surg"},{"issue":"4","key":"23_CR47","doi-asserted-by":"publisher","first-page":"2360","DOI":"10.1167\/iovs.11-9385","volume":"53","author":"P Kamaev","year":"2012","unstructured":"Kamaev P, Friedman M, Sherr E, Muller D (2012) Photochemical kinetics of corneal cross-linking with riboflavin. Invest Ophthalmol Vis Sci 53(4):2360\u20132367","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"23_CR48","doi-asserted-by":"crossref","unstructured":"Kanellopoulos AJ (2009) Comparison of sequential vs same-day simultaneous collagen cross-linking and topography-guided PRK for treatment of keratoconus. J Refract Surg 25(9)","DOI":"10.3928\/1081597X-20090813-10"},{"key":"23_CR49","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.2147\/OPTH.S31256","volume":"6","author":"AJ Kanellopoulos","year":"2012","unstructured":"Kanellopoulos AJ (2012) Long-term safety and efficacy follow-up of prophylactic higher fluence collagen cross-linking in high myopic laser-assisted in situ keratomileusis. Clin Ophthalmol 6:1125\u20131130","journal-title":"Clin Ophthalmol"},{"issue":"2","key":"23_CR50","doi-asserted-by":"publisher","first-page":"88","DOI":"10.3928\/1081597X-20140120-03","volume":"30","author":"AJ Kanellopoulos","year":"2014","unstructured":"Kanellopoulos AJ, Asimellis G (2014) Keratoconus management: long-term stability of topography-guided normalization combined with high-fluence CXL stabilization (the athens protocol). J Refract Surg 30(2):88\u201393","journal-title":"J Refract Surg"},{"issue":"7","key":"23_CR51","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1097\/ICO.0b013e318074e424","volume":"26","author":"J Kanellopoulos","year":"2007","unstructured":"Kanellopoulos J, Binder P (2007) Collagen cross-linking (CCL) with sequential topography-guided PRK: a temporizing alternative for keratoconus to penetrating keratoplasty. Cornea 26(7):891\u2013895","journal-title":"Cornea"},{"issue":"5","key":"23_CR52","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3928\/1081597X-20101105-01","volume":"27","author":"AJ Kanellopoulos","year":"2011","unstructured":"Kanellopoulos AJ, Binder P (2011) Management of corneal ectasia after LASIK with combined, same-day, topography-guided partial transepithelial PRK and collagen cross-linking: the athens protocol. J Refract Surg 27(5):323\u2013331","journal-title":"J Refract Surg"},{"issue":"11 Suppl","key":"23_CR53","doi-asserted-by":"publisher","first-page":"S837","DOI":"10.3928\/1081597X-20121005-05","volume":"28","author":"AJ Kanellopoulos","year":"2012","unstructured":"Kanellopoulos AJ, Kahn J (2012) Topography-guided hyperopic LASIK with and without high irradiance collagen cross-linking: initial comparative clinical findings in a contralateral eye study of 34 consecutive patients. J Refract Surg 28(11 Suppl):S837\u2013S840","journal-title":"J Refract Surg"},{"issue":"13","key":"23_CR54","doi-asserted-by":"publisher","first-page":"9333","DOI":"10.1167\/iovs.11-8382","volume":"52","author":"R Kashiwabuchi","year":"2011","unstructured":"Kashiwabuchi R, Carvalho F, Khan Y, de Freitas D, Foronda A, Hirai F, Campos M, McDonnell P (2011) Assessing efficacy of combined riboflavin and UV-A light (365 nm) treatment of Acanthamoeba trophozoites. Invest Ophthalmol Vis Sci 52(13):9333\u20139338","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"23_CR55","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.ophtha.2010.06.041","volume":"118","author":"Y Khan","year":"2011","unstructured":"Khan Y, Kashiwabuchi R, Martins S, Castro-Combs J, Kalyani S, Stanley P, Flikier D, Behrens A (2011) Riboflavin and ultraviolet light a therapy as an adjuvant treatment for medically refractive Acanthamoeba keratitis. Ophthalmology 118(2):324\u2013331","journal-title":"Ophthalmology"},{"issue":"8","key":"23_CR56","doi-asserted-by":"publisher","first-page":"715","DOI":"10.3109\/02713683.2010.481068","volume":"35","author":"A Kissner","year":"2010","unstructured":"Kissner A, Spoerl E, Jung R, Spekl K, Pillunat L, Raiskup F (2010) Pharmacological modification of the epithelial permeability by benzalkonium chloride in UVA\/Riboflavin corneal collagen cross-linking. Curr Eye Res 35(8):715\u2013721","journal-title":"Curr Eye Res"},{"issue":"2","key":"23_CR57","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.jcrs.2005.12.092","volume":"32","author":"M Kohlhaas","year":"2006","unstructured":"Kohlhaas M, Spoerl E, Schilde T, Unger G, Wittig C, Pillunat L (2006) Biomechanical evidence of the distribution of cross-links in corneas treated with riboflavin and ultraviolet A light. J Cataract Refract Surg 32(2):279\u2013283","journal-title":"J Cataract Refract Surg"},{"issue":"8","key":"23_CR58","doi-asserted-by":"publisher","first-page":"1358","DOI":"10.1016\/j.jcrs.2009.03.035","volume":"35","author":"T Koller","year":"2009","unstructured":"Koller T, Mrochen M, Seiler T (2009) Complication and failure rates after corneal crosslinking. J Cataract Refract Surg 35(8):1358\u20131362","journal-title":"J Cataract Refract Surg"},{"issue":"11","key":"23_CR59","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1016\/j.jcrs.2007.06.036","volume":"33","author":"G Kymionis","year":"2007","unstructured":"Kymionis G, Portaliou D, Bouzoukis D, Suh L, Pallikaris A, Markomanolakis M, Yoo S (2007) Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg 33(11):1982\u20131984","journal-title":"J Cataract Refract Surg"},{"key":"23_CR60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/1471-2415-9-10","volume":"9","author":"G Kymionis","year":"2009","unstructured":"Kymionis G, Diakonis V, Coskunseven E, Jankov M, Yoo S, Pallikaris I (2009a) Customized pachymetric guided epithelial debridement for corneal collagen cross linking. BMC Ophthalmol 9:10","journal-title":"BMC Ophthalmol"},{"issue":"9","key":"23_CR61","doi-asserted-by":"publisher","first-page":"S807","DOI":"10.3928\/1081597X-20090813-09","volume":"25","author":"G Kymionis","year":"2009","unstructured":"Kymionis G, Kontadakis G, Kounis G, Portaliou D, Karavitaki A, Magarakis M, Yoo S, Pallikaris I (2009b) Simultaneous topography-guided PRK followed by corneal collagen cross-linking for keratoconus. J Refract Surg 25(9):S807\u2013S811","journal-title":"J Refract Surg"},{"issue":"12","key":"23_CR62","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1016\/j.ophtha.2009.09.018","volume":"116","author":"G Kymionis","year":"2009","unstructured":"Kymionis G, Kounis G, Portaliou D, Grentzelos M, Karavitaki A, Coskunseven E, Jankov M, Pallikaris I (2009c) Intraoperative pachymetric measurements during corneal collagen cross-linking with riboflavin and ultraviolet A irradiation. Ophthalmology 116(12):2336\u20132339","journal-title":"Ophthalmology"},{"key":"23_CR63","doi-asserted-by":"publisher","first-page":"11","DOI":"10.2174\/1874364101105010010","volume":"5","author":"G Kymionis","year":"2011","unstructured":"Kymionis G, Portaliou D, Diakonis V, Karavitaki A, Panagopoulou S, Jankov Ii M, Coskunseven E (2011) Management of post laser in situ keratomileusis ectasia with simultaneous topography guided photorefractive keratectomy and collagen cross-linking. Open Ophthalmol J 5:11\u201313","journal-title":"Open Ophthalmol J"},{"issue":"1","key":"23_CR64","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.ajo.2011.05.036","volume":"153","author":"G Kymionis","year":"2012","unstructured":"Kymionis G, Portaliou D, Diakonis V, Kounis G, Panagopoulou S, Grentzelos M (2012) Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas. Am J Ophthalmol 153(1):24\u201328","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"23_CR65","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.ajo.2014.07.005","volume":"158","author":"G Kymionis","year":"2014","unstructured":"Kymionis G, Tsoulnaras K, Grentzelos M, Liakopoulos D, Tsakalis N, Blazaki S, Paraskevopoulos T, Tsilimbaris M (2014a) Evaluation of corneal stromal demarcation line depth following standard and a modified-accelerated collagen cross-linking protocol. Am J Ophthalmol 158(4):671\u2013675.e1","journal-title":"Am J Ophthalmol"},{"issue":"5","key":"23_CR66","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1016\/j.jcrs.2013.10.029","volume":"40","author":"G Kymionis","year":"2014","unstructured":"Kymionis G, Tsoulnaras K, Grentzelos M, Plaka A, Mikropoulos D, Liakopoulos D, Tsakalis N, Pallikaris I (2014b) Corneal stroma demarcation line after standard and high-intensity collagen crosslinking determined with anterior segment optical coherence tomography. J Cataract Refract Surg 40(5):736\u2013740","journal-title":"J Cataract Refract Surg"},{"issue":"11","key":"23_CR67","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1038\/eye.2014.173","volume":"28","author":"FC Lam","year":"2014","unstructured":"Lam FC, Geourgoudis P, Nanavaty MA, Khan S, Lake D (2014) Sterile keratitis after combined riboflavin-UVA corneal collagen cross-linking for keratoconus. Eye (Lond) 28(11):1297\u20131303","journal-title":"Eye (Lond)"},{"issue":"12","key":"23_CR68","doi-asserted-by":"publisher","first-page":"942","DOI":"10.3928\/1081597X-20100212-09","volume":"26","author":"A Leccisotti","year":"2010","unstructured":"Leccisotti A, Islam T (2010) Transepithelial corneal collagen cross-linking in keratoconus. J Refract Surg 26(12):942\u2013948","journal-title":"J Refract Surg"},{"issue":"5","key":"23_CR69","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1136\/bjophthalmol-2012-302518","volume":"97","author":"Z Li","year":"2013","unstructured":"Li Z, Jhanji V, Tao X, Yu H, Chen W, Mu G (2013) Riboflavin\/ultraviolet light-mediated crosslinking for fungal keratitis. Br J Ophthalmol 97(5):669\u2013671","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"23_CR70","first-page":"157","volume":"7","author":"N Li","year":"2014","unstructured":"Li N, Peng X-J, Fan Z-J (2014) Progress of corneal collagen cross-linking combined with refractive surgery. Int J Ophthalmol 7(1):157\u2013162","journal-title":"Int J Ophthalmol"},{"issue":"3","key":"23_CR71","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/archophthalmol.2011.23","volume":"129","author":"L Lim","year":"2011","unstructured":"Lim L, Beuerman R, Lim L, Tan D (2011) Late-onset deep stromal scarring after riboflavin-UV-A corneal collagen cross-linking for mild keratoconus. Arch Ophthalmol 129(3):360\u2013362","journal-title":"Arch Ophthalmol"},{"issue":"7","key":"23_CR72","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1038\/eye.2014.98","volume":"28","author":"C MacGregor","year":"2014","unstructured":"MacGregor C, Tsatsos M, Hossain P (2014) Is accelerated corneal collagen cross-linking for keratoconus the way forward? No. Eye 28(7):786\u2013787","journal-title":"Eye"},{"issue":"11","key":"23_CR73","doi-asserted-by":"publisher","first-page":"776","DOI":"10.3928\/1081597X-20121011-05","volume":"28","author":"C Malhotra","year":"2012","unstructured":"Malhotra C, Shetty R, Kumar R, Veluri H, Nagaraj H, Shetty B (2012) In vivo imaging of riboflavin penetration during collagen cross-linking with hand-held spectral domain optical coherence tomography. J Refract Surg 28(11):776\u2013780","journal-title":"J Refract Surg"},{"issue":"3","key":"23_CR74","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1016\/0925-4439(92)90041-K","volume":"1138","author":"NS Malik","year":"1992","unstructured":"Malik NS, Moss SJ, Ahmed N, Furth AJ, Wall RS, Meek KM (1992) Ageing of the human corneal stroma: structural and biochemical changes. Biochim Biophys Acta 1138(3):222\u2013228","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"23_CR75","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3928\/1081597X-20100326-01","volume":"26","author":"G Mangioris","year":"2010","unstructured":"Mangioris G, Papadopoulou D, Balidis M, Poulas J, Papadopoulos NT, Seiler T (2010) Corneal infiltrates after corneal collagen cross-linking. J Refract Surg 26(8):609\u2013611","journal-title":"J Refract Surg"},{"issue":"10","key":"23_CR76","doi-asserted-by":"publisher","first-page":"6378","DOI":"10.1167\/iovs.12-9913","volume":"53","author":"A Marcovich","year":"2012","unstructured":"Marcovich A, Brandis A, Daphna O, Feine I, Pinkas I, Goldschmidt R, Kalchenko V, Berkutzki T, Wagner D, Salomon Y, Scherz A (2012) Stiffening of rabbit corneas by the bacteriochlorophyll derivative WST11 using near infrared light. Invest Ophthalmol Vis Sci 53(10):6378\u20136388","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"8","key":"23_CR77","doi-asserted-by":"publisher","first-page":"3402","DOI":"10.1167\/iovs.07-1592","volume":"49","author":"SA Martins","year":"2008","unstructured":"Martins SA, Combs JC, Noguera G, Camacho W, Wittmann P, Walther R, Cano M, Dick J, Behrens A (2008) Antimicrobial efficacy of riboflavin\/UVA combination (365 nm) in vitro for bacterial and fungal isolates: a potential new treatment for infectious keratitis. Invest Ophthalmol Vis Sci 49(8):3402\u20133408","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"23_CR78","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1097\/ICO.0b013e3182844c60","volume":"32","author":"L Mastropasqua","year":"2013","unstructured":"Mastropasqua L, Nubile M, Lanzini M, Calienno R, Mastropasqua R, Agnifili L, Toto L (2013) Morphological modification of the cornea after standard and transepithelial corneal cross-linking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy. Cornea 32(6):855\u2013861","journal-title":"Cornea"},{"issue":"6","key":"23_CR79","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1111\/j.1442-9071.2007.01536.x","volume":"35","author":"C Mazzotta","year":"2007","unstructured":"Mazzotta C, Balestrazzi A, Baiocchi S, Traversi C, Caporossi A (2007) Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation. Clin Exp Ophthalmol 35(6):580\u2013582","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"23_CR80","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.ajo.2008.05.042","volume":"146","author":"C Mazzotta","year":"2008","unstructured":"Mazzotta C, Traversi C, Baiocchi S, Caporossi O, Bovone C, Sparano M, Balestrazzi A, Caporossi A (2008) Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 146(4):527\u2013533","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"23_CR81","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1111\/j.1755-3768.2010.01890.x","volume":"90","author":"C Mazzotta","year":"2012","unstructured":"Mazzotta C, Caporossi T, Denaro R, Bovone C, Sparano C, Paradiso A, Baiocchi S, Caporossi A (2012) Morphological and functional correlations in riboflavin UV A corneal collagen cross-linking for keratoconus. Acta Ophthalmol 90(3):259\u2013265","journal-title":"Acta Ophthalmol"},{"issue":"10","key":"23_CR82","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1038\/eye.2014.163","volume":"28","author":"C Mazzotta","year":"2014","unstructured":"Mazzotta C, Traversi C, Caragiuli S, Rechichi M (2014) Pulsed vs continuous light accelerated corneal collagen crosslinking: in vivo qualitative investigation by confocal microscopy and corneal OCT. Eye (Lond) 28(10):1179\u20131183","journal-title":"Eye (Lond)"},{"issue":"2","key":"23_CR83","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/opo.12032","volume":"33","author":"K Meek","year":"2013","unstructured":"Meek K, Hayes S (2013) Corneal cross-linking--a review. Ophthalmic Physiol Opt 33(2):78\u201393","journal-title":"Ophthalmic Physiol Opt"},{"issue":"1","key":"23_CR84","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/j.1442-9071.2010.02207.x","volume":"38","author":"R Mencucci","year":"2010","unstructured":"Mencucci R, Marini M, Paladini I, Sarchielli E, Sgambati E, Menchini U, Vannelli G (2010) Effects of riboflavin\/UVA corneal cross-linking on keratocytes and collagen fibres in human cornea. Clin Exp Ophthalmol 38(1):49\u201356","journal-title":"Clin Exp Ophthalmol"},{"issue":"7","key":"23_CR85","doi-asserted-by":"publisher","first-page":"474","DOI":"10.3928\/1081597X-20140429-02","volume":"30","author":"M Moshirfar","year":"2014","unstructured":"Moshirfar M, Edmonds J, Behunin N, Christiansen S (2014) Current options in the management of pellucid marginal degeneration. J Refract Surg 30(7):474\u2013485","journal-title":"J Refract Surg"},{"issue":"1","key":"23_CR86","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/S0886-3350(88)80063-4","volume":"14","author":"CR Munnerlyn","year":"1988","unstructured":"Munnerlyn CR, Koons SJ, Marshall J (1988) Photorefractive keratectomy: a technique for laser refractive surgery. J Cataract Refract Surg 14(1):46\u201352","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"23_CR87","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000265406","volume":"18","author":"K Nakayasu","year":"1986","unstructured":"Nakayasu K, Tanaka M, Konomi H, Hayashi T (1986) Distribution of types I, II, III, IV and V collagen in normal and keratoconus corneas. Ophthalmic Res 18(1):1\u201310","journal-title":"Ophthalmic Res"},{"key":"23_CR88","unstructured":"Nishida T, Saika S (2011) Corneal and sclera: anatomy and physiology. In: Krachmer J, Mannis M, Holland E (eds) Cornea, vol 1. Mosby, Philadelphia, pp 4\u201324"},{"issue":"11","key":"23_CR89","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1136\/bjo.2010.196493","volume":"95","author":"D O\u2019Brart","year":"2011","unstructured":"O\u2019Brart D, Chan E, Samaras K, Patel P, Shah S (2011) A randomised, prospective study to investigate the efficacy of riboflavin\/ultraviolet A (370\u2005nm) corneal collagen cross-linkage to halt the progression of keratoconus. Br J Ophthalmol 95(11):1519\u20131524","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"23_CR90","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1136\/bjophthalmol-2012-302556","volume":"97","author":"D O\u2019Brart","year":"2013","unstructured":"O\u2019Brart D, Kwong T, Patel P, McDonald R, O\u2019Brart N (2013) Long-term follow-up of riboflavin\/ultraviolet A (370 nm) corneal collagen cross-linking to halt the progression of keratoconus. Br J Ophthalmol 97(4):433\u2013437","journal-title":"Br J Ophthalmol"},{"issue":"8","key":"23_CR91","doi-asserted-by":"publisher","first-page":"422","DOI":"10.4103\/0301-4738.116073","volume":"61","author":"P Padmanabhan","year":"2013","unstructured":"Padmanabhan P, Dave A (2013) Collagen cross-linking in thin corneas. Indian J Ophthalmol 61(8):422\u2013424","journal-title":"Indian J Ophthalmol"},{"issue":"3","key":"23_CR92","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1167\/iovs.08-2202","volume":"50","author":"D Paik","year":"2009","unstructured":"Paik D, Wen Q, Braunstein R, Airiani S, Trokel S (2009) Initial studies using aliphatic beta-nitro alcohols for therapeutic corneal cross-linking. Invest Ophthalmol Vis Sci 50(3):1098\u20131105","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"23_CR93","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1167\/iovs.09-3937","volume":"51","author":"D Paik","year":"2010","unstructured":"Paik D, Solomon M, Wen Q, Turro N, Trokel S (2010) Aliphatic beta-nitroalcohols for therapeutic corneoscleral cross-linking: chemical mechanisms and higher order nitroalcohols. Invest Ophthalmol Vis Sci 51(2):836\u2013843","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"23_CR94","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1016\/j.jcrs.2009.01.036","volume":"35","author":"J P\u00e9rez-Santonja","year":"2009","unstructured":"P\u00e9rez-Santonja J, Artola A, Javaloy J, Ali\u00f3 J, Abad J (2009) Microbial keratitis after corneal collagen crosslinking. J Cataract Refract Surg 35(6):1138\u20131140","journal-title":"J Cataract Refract Surg"},{"issue":"3","key":"23_CR95","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.jcrs.2008.09.029","volume":"35","author":"M Pollhammer","year":"2009","unstructured":"Pollhammer M, Cursiefen C (2009) Bacterial keratitis early after corneal crosslinking with riboflavin and ultraviolet-A. J Cataract Refract Surg 35(3):588\u2013589","journal-title":"J Cataract Refract Surg"},{"issue":"10","key":"23_CR96","doi-asserted-by":"publisher","first-page":"706","DOI":"10.3928\/1081597X-20120921-06","volume":"28","author":"M Price","year":"2012","unstructured":"Price M, Tenkman L, Schrier A, Fairchild K, Trokel S, Price F (2012) Photoactivated riboflavin treatment of infectious keratitis using collagen cross-linking technology. J Refract Surg 28(10):706\u2013713","journal-title":"J Refract Surg"},{"issue":"5","key":"23_CR97","doi-asserted-by":"crossref","first-page":"371","DOI":"10.3928\/1081-597X-19950901-14","volume":"11","author":"YS Rabinowitz","year":"1995","unstructured":"Rabinowitz YS (1995) Videokeratographic indices to aid in screening for keratoconus. J Refract Surg 11(5):371\u2013379","journal-title":"J Refract Surg"},{"issue":"2","key":"23_CR98","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.jtos.2013.01.002","volume":"11","author":"F Raiskup","year":"2013","unstructured":"Raiskup F, Spoerl E (2013) Corneal crosslinking with riboflavin and ultraviolet A. I. Principles. Ocul Surf 11(2):65\u201374","journal-title":"Ocul Surf"},{"key":"23_CR99","doi-asserted-by":"crossref","unstructured":"Raiskup F, Hoyer A, Spoerl E (2009) Permanent corneal haze after riboflavin-UVA-induced cross-linking in keratoconus. J Refract Surg 25(9)","DOI":"10.3928\/1081597X-20090813-12"},{"issue":"3","key":"23_CR100","doi-asserted-by":"publisher","first-page":"234","DOI":"10.3109\/02713683.2011.637656","volume":"37","author":"F Raiskup","year":"2012","unstructured":"Raiskup F, Pinelli R, Spoerl E (2012) Riboflavin osmolar modification for transepithelial corneal cross-linking. Curr Eye Res 37(3):234\u2013238","journal-title":"Curr Eye Res"},{"issue":"5","key":"23_CR101","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1016\/j.jcrs.2007.12.039","volume":"34","author":"F Raiskup-Wolf","year":"2008","unstructured":"Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat L (2008) Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg 34(5):796\u2013801","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"23_CR102","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1016\/j.jcrs.2008.09.035","volume":"35","author":"P Rama","year":"2009","unstructured":"Rama P, Di Matteo F, Matuska S, Paganoni G, Spinelli A (2009) Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use. J Cataract Refract Surg 35(4):788\u2013791","journal-title":"J Cataract Refract Surg"},{"issue":"4","key":"23_CR103","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/01.icu.0000233963.26628.f0","volume":"17","author":"B Randleman","year":"2006","unstructured":"Randleman B (2006) Post-laser in-situ keratomileusis ectasia: current understanding and future directions. Curr Opin Ophthalmol 17(4):406\u2013412","journal-title":"Curr Opin Ophthalmol"},{"issue":"7","key":"23_CR104","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1167\/tvst.2.7.6","volume":"2","author":"O Richoz","year":"2013","unstructured":"Richoz O, Hammer A, Tabibian D, Gatzioufas Z, Hafezi F (2013a) The biomechanical effect of corneal collagen cross-linking (CXL) with riboflavin and UV-A is oxygen dependent. Transl Vis Sci Technol 2(7):6","journal-title":"Transl Vis Sci Technol"},{"issue":"7","key":"23_CR105","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.1016\/j.ophtha.2012.12.027","volume":"120","author":"O Richoz","year":"2013","unstructured":"Richoz O, Mavrakanas N, Pajic B, Hafezi F (2013b) Corneal collagen cross-linking for ectasia after LASIK and photorefractive keratectomy: long-term results. Ophthalmology 120(7):1354\u20131359","journal-title":"Ophthalmology"},{"issue":"9","key":"23_CR106","doi-asserted-by":"publisher","first-page":"5783","DOI":"10.1167\/iovs.14-14695","volume":"55","author":"O Richoz","year":"2014","unstructured":"Richoz O, Tabibian D, Hammer A, Majo F, Nicolas M, Hafezi F (2014) The effect of standard and high-fluence corneal cross-linking (CXL) on cornea and limbus. Invest Ophthalmol Vis Sci 55(9):5783\u20135787","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"23_CR107","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1006\/bbrc.1995.2356","volume":"214","author":"C Sady","year":"1995","unstructured":"Sady C, Khosrof S, Nagaraj R (1995) Advanced Maillard reaction and crosslinking of corneal collagen in diabetes. Biochem Biophys Res Commun 214(3):793\u2013797","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"23_CR108","doi-asserted-by":"publisher","first-page":"1377","DOI":"10.1016\/j.ophtha.2014.01.011","volume":"121","author":"D Said","year":"2014","unstructured":"Said D, Elalfy M, Gatzioufas Z, El-Zakzouk E, Hassan M, Saif M, Zaki A, Dua H, Hafezi F (2014) Collagen cross-linking with photoactivated riboflavin (PACK-CXL) for the treatment of advanced infectious keratitis with corneal melting. Ophthalmology 121(7):1377\u20131382","journal-title":"Ophthalmology"},{"issue":"9","key":"23_CR109","doi-asserted-by":"publisher","first-page":"771","DOI":"10.3928\/1081597X-20090813-03","volume":"25","author":"K Samaras","year":"2009","unstructured":"Samaras K, O\u2019Brart D, Doutch J, Hayes S, Marshall J, Meek K (2009) Effect of epithelial retention and removal on riboflavin absorption in porcine corneas. J Refract Surg 25(9):771\u2013775","journal-title":"J Refract Surg"},{"issue":"12","key":"23_CR110","doi-asserted-by":"publisher","first-page":"9048","DOI":"10.1167\/iovs.11-7818","volume":"52","author":"S Schumacher","year":"2011","unstructured":"Schumacher S, Oeftiger L, Mrochen M (2011) Equivalence of biomechanical changes induced by rapid and standard corneal cross-linking, using riboflavin and ultraviolet radiation. Invest Ophthalmol Vis Sci 52(12):9048\u20139052","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"23_CR111","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3928\/1081-597X-19980501-15","volume":"14","author":"T Seiler","year":"1998","unstructured":"Seiler T, Koufala K, Richter G (1998) Iatrogenic keratectasia after laser in situ keratomileusis. J Refract Surg 14(3):312\u2013317","journal-title":"J Refract Surg"},{"issue":"3","key":"23_CR112","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jcrs.2009.08.041","volume":"36","author":"N Sharma","year":"2010","unstructured":"Sharma N, Maharana P, Singh G, Titiyal J (2010) Pseudomonas keratitis after collagen crosslinking for keratoconus: case report and review of literature. J Cataract Refract Surg 36(3):517\u2013520","journal-title":"J Cataract Refract Surg"},{"key":"23_CR113","doi-asserted-by":"crossref","unstructured":"Sharma A, Nottage JM, Mirchia K, Sharma R, Mohan K, Nirankari VS (2012) Persistent corneal edema after collagen cross-linking for keratoconus. Am J Ophthalmol 154(6)","DOI":"10.1016\/j.ajo.2012.06.005"},{"issue":"3","key":"23_CR114","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1097\/ICO.0000000000000004","volume":"33","author":"N Sharma","year":"2014","unstructured":"Sharma N, Roy S, Maharana P, Sehra S, Sinha R, Tandon R, Titiyal J, Vajpayee R (2014) Outcomes of corneal collagen crosslinking in pseudophakic bullous keratopathy. Cornea 33(3):243\u2013246","journal-title":"Cornea"},{"key":"23_CR115","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.2147\/OPTH.S59840","volume":"8","author":"AM Sherif","year":"2014","unstructured":"Sherif AM (2014) Accelerated versus conventional corneal collagen cross-linking in the treatment of mild keratoconus: a comparative study. Clin Ophthalmol 8:1435\u20131440","journal-title":"Clin Ophthalmol"},{"key":"23_CR116","doi-asserted-by":"publisher","unstructured":"Shetty R, Kaweri L, Nuijts R, Nagaraja H, Arora V, Kumar R (2014a) Profile of microbial keratitis after corneal collagen cross-linking. Biomed Res Int 2014:340509. doi: 10.1155\/2014\/340509 , Epub 2014 Sept 11","DOI":"10.1155\/2014\/340509"},{"key":"23_CR117","doi-asserted-by":"crossref","unstructured":"Shetty R, Nagaraja H, Jayadev C, Shivanna Y, Kugar T (2014b) Collagen crosslinking in the management of advanced non-resolving microbial keratitis. Br J Ophthalmol 98(8):1033\u20131035","DOI":"10.1136\/bjophthalmol-2014-304944"},{"issue":"1","key":"23_CR118","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1146\/annurev.biochem.77.032207.120833","volume":"78","author":"M Shoulders","year":"2009","unstructured":"Shoulders M, Raines R (2009) Collagen structure and stability. Annu Rev Biochem 78(1):929\u2013958","journal-title":"Annu Rev Biochem"},{"issue":"1","key":"23_CR119","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1159\/000357979","volume":"232","author":"N Sorkin","year":"2014","unstructured":"Sorkin N, Varssano D (2014) Corneal collagen crosslinking: a systematic review. Ophthalmologica 232(1):10\u201327","journal-title":"Ophthalmologica"},{"issue":"5","key":"23_CR120","doi-asserted-by":"publisher","first-page":"375","DOI":"10.3928\/1081597X-20100114-03","volume":"26","author":"L Spadea","year":"2010","unstructured":"Spadea L (2010) Corneal collagen cross-linking with riboflavin and UVA irradiation in pellucid marginal degeneration. J Refract Surg 26(5):375\u2013377","journal-title":"J Refract Surg"},{"issue":"6","key":"23_CR121","first-page":"711","volume":"15","author":"E Spoerl","year":"1999","unstructured":"Spoerl E, Seiler T (1999) Techniques for stiffening the cornea. J Refract Surg 15(6):711\u2013713","journal-title":"J Refract Surg"},{"issue":"1","key":"23_CR122","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1006\/exer.1997.0410","volume":"66","author":"E Spoerl","year":"1998","unstructured":"Spoerl E, Huhle M, Seiler T (1998) Induction of cross-links in corneal tissue. Exp Eye Res 66(1):97\u2013103","journal-title":"Exp Eye Res"},{"issue":"2","key":"23_CR123","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1159\/000076150","volume":"218","author":"E Spoerl","year":"2004","unstructured":"Spoerl E, Wollensak G, Dittert D-D, Seiler T (2004a) Thermomechanical behavior of collagen-cross-linked porcine cornea. Ophthalmologica 218(2):136\u2013140","journal-title":"Ophthalmologica"},{"issue":"1","key":"23_CR124","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1080\/02713680490513182","volume":"29","author":"E Spoerl","year":"2004","unstructured":"Spoerl E, Wollensak G, Seiler T (2004b) Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res 29(1):35\u201340","journal-title":"Curr Eye Res"},{"key":"23_CR125","doi-asserted-by":"crossref","unstructured":"Stojanovic A, Chen X, Jin N, Zhang T, Stojanovic F, Raeder S, Utheim TP (2012) Safety and efficacy of epithelium-on corneal collagen cross-linking using a multifactorial approach to achieve proper stromal riboflavin saturation. J Ophthalmol 2012","DOI":"10.1155\/2012\/498435"},{"issue":"6","key":"23_CR126","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1097\/ICO.0b013e31823f8c72","volume":"31","author":"J Sugar","year":"2012","unstructured":"Sugar J, Macsai M (2012) What causes keratoconus? Cornea 31(6):716\u2013719","journal-title":"Cornea"},{"issue":"1","key":"23_CR127","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/cxo.12075","volume":"97","author":"G Sutton","year":"2014","unstructured":"Sutton G, Lawless M, Hodge C (2014) Laser in situ keratomileusis in 2012: a review. Clin Exp Optom 97(1):18\u201329","journal-title":"Clin Exp Optom"},{"key":"23_CR128","doi-asserted-by":"publisher","first-page":"624563","DOI":"10.1155\/2013\/624563","volume":"2013","author":"X Tao","year":"2013","unstructured":"Tao X, Yu H, Zhang Y, Li Z, Jhanji V, Ni S, Wang Y, Mu G (2013) Role of corneal epithelium in riboflavin\/ultraviolet-A mediated corneal cross-linking treatment in rabbit eyes. Biomed Res Int 2013:624563. doi: 10.1155\/2013\/624563 , Epub 2013 Jun 27","journal-title":"Biomed Res Int"},{"issue":"6","key":"23_CR129","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1016\/j.jcrs.2013.12.012","volume":"40","author":"M Tomita","year":"2014","unstructured":"Tomita M, Mita M, Huseynova T (2014) Accelerated versus conventional corneal collagen crosslinking. J Cataract Refract Surg 40(6):1013\u20131020","journal-title":"J Cataract Refract Surg"},{"issue":"11","key":"23_CR130","doi-asserted-by":"publisher","first-page":"769","DOI":"10.3928\/1081597X-20121016-01","volume":"28","author":"D Touboul","year":"2012","unstructured":"Touboul D, Efron N, Smadja D, Praud D, Malet F, Colin J (2012) Corneal confocal microscopy following conventional, transepithelial, and accelerated corneal collagen cross-linking procedures for keratoconus. J Refract Surg 28(11):769\u2013776","journal-title":"J Refract Surg"},{"issue":"7","key":"23_CR131","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/eye.2014.97","volume":"28","author":"M Tsatsos","year":"2014","unstructured":"Tsatsos M, MacGregor C, Kopsachilis N, Anderson D (2014) Is accelerated corneal collagen cross-linking for keratoconus the way forward? Yes. Eye 28(7):784\u2013785","journal-title":"Eye"},{"key":"23_CR132","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/ceo.12399","volume":"43","author":"R Vajpayee","year":"2015","unstructured":"Vajpayee R, Shafi S, Maharana P, Sharma N, Jhanji V (2015) Evaluation of corneal collagen cross-linking as an additional therapy in mycotic keratitis. Clin Exp Ophthalmol 43:103\u2013107","journal-title":"Clin Exp Ophthalmol"},{"issue":"4","key":"23_CR133","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1001\/jamaophthalmol.2013.5841","volume":"132","author":"K Dijk van","year":"2014","unstructured":"van Dijk K, Parker J, Tong CM, Ham L, Lie JT, Groeneveld-van Beek EA, Melles GR (2014) Midstromal isolated Bowman layer graft for reduction of advanced keratoconus: a technique to postpone penetrating or deep anterior lamellar keratoplasty. JAMA Ophthalmol 132(4):495\u2013501","journal-title":"JAMA Ophthalmol"},{"key":"23_CR134","first-page":"2019","volume":"7","author":"J Vazirani","year":"2013","unstructured":"Vazirani J, Basu S (2013) Keratoconus: current perspectives. Clin Ophthalmol 7:2019\u20132030","journal-title":"Clin Ophthalmol"},{"issue":"8","key":"23_CR135","doi-asserted-by":"publisher","first-page":"441","DOI":"10.4103\/0301-4738.116068","volume":"61","author":"J Vazirani","year":"2013","unstructured":"Vazirani J, Vaddavalli P (2013) Cross-linking for microbial keratitis. Indian J Ophthalmol 61(8):441\u2013444","journal-title":"Indian J Ophthalmol"},{"issue":"5","key":"23_CR136","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1016\/j.ophtha.2012.10.023","volume":"120","author":"R Vinciguerra","year":"2013","unstructured":"Vinciguerra R, Romano M, Camesasca F, Azzolini C, Trazza S, Morenghi E, Vinciguerra P (2013) Corneal cross-linking as a treatment for keratoconus. Ophthalmology 120(5):908\u2013916","journal-title":"Ophthalmology"},{"issue":"4","key":"23_CR137","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.ophtha.2013.10.028","volume":"121","author":"C Wittig-Silva","year":"2014","unstructured":"Wittig-Silva C, Chan E, Islam F, Wu T, Whiting M, Snibson G (2014) A randomized, controlled trial of corneal collagen cross-linking in progressive keratoconus: three-year results. Ophthalmology 121(4):812\u2013821","journal-title":"Ophthalmology"},{"issue":"2","key":"23_CR138","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1111\/j.1755-3768.2008.01474.x","volume":"88","author":"G Wollensak","year":"2010","unstructured":"Wollensak G (2010) Histological changes in human cornea after cross-linking with riboflavin and ultraviolet A. Acta Ophthalmol 88(2):e17\u2013e18","journal-title":"Acta Ophthalmol"},{"issue":"3","key":"23_CR139","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.jcrs.2008.11.036","volume":"35","author":"G Wollensak","year":"2009","unstructured":"Wollensak G, Iomdina E (2009a) Biomechanical and histological changes after corneal crosslinking with and without epithelial debridement. J Cataract Refract Surg 35(3):540\u2013546","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"23_CR140","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1111\/j.1755-3768.2008.01190.x","volume":"87","author":"G Wollensak","year":"2009","unstructured":"Wollensak G, Iomdina E (2009b) Long-term biomechanical properties of rabbit cornea after photodynamic collagen crosslinking. Acta Ophthalmol 87(1):48\u201351","journal-title":"Acta Ophthalmol"},{"issue":"5","key":"23_CR141","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1016\/S0002-9394(02)02220-1","volume":"135","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003a) Riboflavin\/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135(5):620\u2013627","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"23_CR142","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1016\/S0886-3350(03)00407-3","volume":"29","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Seiler T (2003b) Stress-strain measurements of human and porcine corneas after riboflavin-ultraviolet-A-induced cross-linking. J Cataract Refract Surg 29(9):1780\u20131785","journal-title":"J Cataract Refract Surg"},{"issue":"9","key":"23_CR143","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.1016\/S0886-3350(03)00343-2","volume":"29","author":"G Wollensak","year":"2003","unstructured":"Wollensak G, Spoerl E, Wilsch M, Seiler T (2003c) Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg 29(9):1786\u20131790","journal-title":"J Cataract Refract Surg"},{"issue":"1","key":"23_CR144","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00003226-200401000-00008","volume":"23","author":"G Wollensak","year":"2004","unstructured":"Wollensak G, Spoerl E, Wilsch M, Seiler T (2004a) Keratocyte apoptosis after corneal collagen cross-linking using riboflavin\/UVA treatment. Cornea 23(1):43\u201349","journal-title":"Cornea"},{"issue":"5","key":"23_CR145","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1097\/01.ico.0000105827.85025.7f","volume":"23","author":"G Wollensak","year":"2004","unstructured":"Wollensak G, Wilsch M, Spoerl E, Seiler T (2004b) Collagen fiber diameter in the rabbit cornea after collagen crosslinking by riboflavin\/UVA. Cornea 23(5):503\u2013507","journal-title":"Cornea"},{"issue":"4","key":"23_CR146","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.exer.2011.06.021","volume":"93","author":"Y Xia","year":"2011","unstructured":"Xia Y, Chai X, Zhou C, Ren Q (2011) Corneal nerve morphology and sensitivity changes after ultraviolet A\/riboflavin treatment. Exp Eye Res 93(4):541\u2013547","journal-title":"Exp Eye Res"},{"issue":"10","key":"23_CR147","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1016\/j.jcrs.2014.01.042","volume":"40","author":"A Yildirim","year":"2014","unstructured":"Yildirim A, Cakir H, Kara N, Uslu H, Gurler B, Ozgurhan EB, Colak HN (2014) Corneal collagen crosslinking for ectasia after laser in situ keratomileusis: long-term results. J Cataract Refract Surg 40(10):1591\u20131596","journal-title":"J Cataract Refract Surg"},{"issue":"6","key":"23_CR148","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s10792-011-9489-x","volume":"31","author":"N Yuksel","year":"2011","unstructured":"Yuksel N, Bilgihan K, Hondur A (2011) Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus. Int Ophthalmol 31(6):513\u2013515","journal-title":"Int Ophthalmol"},{"issue":"4","key":"23_CR149","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1097\/ICO.0b013e31818d381a","volume":"28","author":"K Zamora","year":"2009","unstructured":"Zamora K, Males J (2009) Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: a case report. Cornea 28(4):474\u2013476","journal-title":"Cornea"}],"container-title":["Handbook of Experimental Pharmacology","Pharmacologic Therapy of Ocular Disease"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2016_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T08:55:56Z","timestamp":1657616156000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/164_2016_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"ISBN":["9783319582887","9783319582900"],"references-count":149,"URL":"https:\/\/doi.org\/10.1007\/164_2016_23","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"type":"print","value":"0171-2004"},{"type":"electronic","value":"1865-0325"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"5 November 2016","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}