{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:34:38Z","timestamp":1761863678529},"publisher-location":"Cham","reference-count":78,"publisher":"Springer International Publishing","isbn-type":[{"type":"print","value":"9783030105068"},{"type":"electronic","value":"9783030105075"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/164_2017_19","type":"book-chapter","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T16:46:58Z","timestamp":1491410818000},"page":"145-159","source":"Crossref","is-referenced-by-count":1,"title":["Plasticity of Resistance and Sensitivity to Anti-Epidermal Growth Factor Receptor Inhibitors in Metastatic Colorectal Cancer"],"prefix":"10.1007","author":[{"given":"Andrea","family":"Sartore-Bianchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Siena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,4,6]]},"reference":[{"key":"19_CR1","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1200\/JCO.2007.14.7116","volume":"26","author":"RG Amado","year":"2008","unstructured":"Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD (2008) J Clin Oncol 26:1626\u20131634","journal-title":"J Clin Oncol"},{"key":"19_CR2","doi-asserted-by":"publisher","first-page":"2157","DOI":"10.1158\/1078-0432.CCR-14-2821","volume":"21","author":"S Arena","year":"2015","unstructured":"Arena S, Bellosillo B, Siravegna G, Mart\u00ednez A, Ca\u00f1adas I, Lazzari L, Ferruz N, Russo M, Misale S, Gonz\u00e1lez I, Iglesias M, Gavilan E, Corti G, Hobor S, Crisafulli G, Salido M, S\u00e1nchez J, Dalmases A, Bellmunt J, De Fabritiis G, Rovira A, Di Nicolantonio F, Albanell J, Bardelli A, Montagut C (2015) Clin Cancer Res 21:2157\u20132166","journal-title":"Clin Cancer Res"},{"key":"19_CR3","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1200\/JCO.2009.24.6116","volume":"28","author":"A Bardelli","year":"2010","unstructured":"Bardelli A, Siena S (2010) J Clin Oncol 28:1254\u20131261","journal-title":"J Clin Oncol"},{"key":"19_CR4","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1158\/2159-8290.CD-12-0558","volume":"3","author":"A Bardelli","year":"2013","unstructured":"Bardelli A, Corso S, Bertotti A, Hobor S, Valtorta E, Siravegna G, Sartore-Bianchi A, Scala E, Cassingena A, Zecchin D, Apicella M, Migliardi G, Galimi F, Lauricella C, Zanon C, Perera T, Veronese S, Corti G, Amatu A, Gambacorta M, Diaz LA, Sausen M, Velculescu VE, Comoglio P, Trusolino L, Di Nicolantonio F, Giordano S, Siena S (2013) Cancer Discov 3:658\u2013673","journal-title":"Cancer Discov"},{"key":"19_CR5","doi-asserted-by":"publisher","first-page":"2643","DOI":"10.1158\/0008-5472.CAN-06-4158","volume":"67","author":"S Benvenuti","year":"2007","unstructured":"Benvenuti S, Sartore-Bianchi A, Di Nicolantonio F, Zanon C, Moroni M, Veronese S, Siena S, Bardelli A (2007) Cancer Res 67:2643\u20132648","journal-title":"Cancer Res"},{"key":"19_CR6","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1158\/2159-8290.CD-11-0109","volume":"1","author":"A Bertotti","year":"2011","unstructured":"Bertotti A, Migliardi G, Galimi F, Sassi F, Torti D, Isella C, Cor\u00e0 D, Di Nicolantonio F, Buscarino M, Petti C, Ribero D, Russolillo N, Muratore A, Massucco P, Pisacane A, Molinaro L, Valtorta E, Sartore-Bianchi A, Risio M, Capussotti L, Gambacorta M, Siena S, Medico E, Sapino A, Marsoni S, Comoglio PM, Bardelli A, Trusolino L (2011) Cancer Discov 1:508\u2013523","journal-title":"Cancer Discov"},{"key":"19_CR7","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1038\/nature14969","volume":"526","author":"A Bertotti","year":"2015","unstructured":"Bertotti A, Papp E, Jones S, Adleff V, Anagnostou V, Lupo B, Sausen M, Phallen J, Hruban CA, Tokheim C, Niknafs N, Nesselbush M, Lytle K, Sassi F, Cottino F, Migliardi G, Zanella ER, Ribero D, Russolillo N, Mellano A, Muratore A, Paraluppi G, Salizzoni M, Marsoni S, Kragh M, Lantto J, Cassingena A, Li QK, Karchin R, Scharpf R, Sartore-Bianchi A, Siena S, Diaz LA, Trusolino L, Velculescu VE (2015) Nature 526:263\u2013267","journal-title":"Nature"},{"key":"19_CR8","doi-asserted-by":"publisher","first-page":"224ra24","DOI":"10.1126\/scitranslmed.3007094","volume":"6","author":"C Bettegowda","year":"2014","unstructured":"Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong S-M, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SKN, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih L-M, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang T-L, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA (2014) Sci Transl Med 6:224ra24","journal-title":"Sci Transl Med"},{"key":"19_CR9","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1038\/nature11252","volume":"487","author":"Cancer Genome Atlas Network","year":"2012","unstructured":"Cancer Genome Atlas Network (2012) Nature 487:330\u2013337","journal-title":"Nature"},{"key":"19_CR10","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1200\/JCO.2005.08.037","volume":"23","author":"KY Chung","year":"2005","unstructured":"Chung KY, Shia J, Kemeny NE, Shah M, Schwartz GK, Tse A, Hamilton A, Pan D, Schrag D, Schwartz L, Klimstra DS, Fridman D, Kelsen DP, Saltz LB (2005) J Clin Oncol 23:1803\u20131810","journal-title":"J Clin Oncol"},{"key":"19_CR11","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1146\/annurev-med-051513-102539","volume":"66","author":"KK Ciombor","year":"2015","unstructured":"Ciombor KK, Wu C, Goldberg RM (2015) Annu Rev Med 66:83\u201395","journal-title":"Annu Rev Med"},{"key":"19_CR12","first-page":"5s","volume":"32","author":"RB Corcoran","year":"2014","unstructured":"Corcoran RB, Atreya CE, Falchook GS, Infante JR, Hamid O, Messersmith WA, Daud A, Kwak EL, Ryan D, Kurzrock R, Sun P, Cunningham EA, Orford KW, Motwani M, Bai Y, Patel K, Venook AP, Kopetz S (2014) J Clin Oncol 32:5s","journal-title":"J Clin Oncol"},{"key":"19_CR13","doi-asserted-by":"publisher","first-page":"2092","DOI":"10.1093\/annonc\/mdv290","volume":"26","author":"C Cremolini","year":"2015","unstructured":"Cremolini C, Di Bartolomeo M, Amatu A, Antoniotti C, Moretto R, Berenato R, Perrone F, Tamborini E, Aprile G, Lonardi S, Sartore-Bianchi A, Fontanini G, Milione M, Lauricella C, Siena S, Falcone A, de Braud F, Loupakis F, Pietrantonio F (2015) Ann Oncol Off J Eur Soc Med Oncol 26:2092\u20132097","journal-title":"Ann Oncol Off J Eur Soc Med Oncol"},{"key":"19_CR14","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1056\/NEJMoa033025","volume":"351","author":"D Cunningham","year":"2004","unstructured":"Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, Chau I, Van Cutsem E (2004) N Engl J Med 351:337\u2013345","journal-title":"N Engl J Med"},{"key":"19_CR15","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/iep.12021","volume":"94","author":"E Day","year":"2013","unstructured":"Day E, Poulogiannis G, McCaughan F, Mulholland S, Arends MJ, Ibrahim AEK, Dear PH (2013) Int J Exp Pathol 94:203\u2013211","journal-title":"Int J Exp Pathol"},{"key":"19_CR16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1016\/S1470-2045(10)70130-3","volume":"11","author":"W Roock De","year":"2010","unstructured":"De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, Kalogeras KT, Kotoula V, Papamichael D, Laurent-Puig P, Penault-Llorca F, Rougier P, Vincenzi B, Santini D, Tonini G, Cappuzzo F, Frattini M, Molinari F, Saletti P, De Dosso S, Martini M, Bardelli A, Siena S, Sartore-Bianchi A, Tabernero J, Macarulla T, Di Fiore F, Gangloff AO, Ciardiello F, Pfeiffer P, Qvortrup C, Hansen TP, Van Cutsem E, Piessevaux H, Lambrechts D, Delorenzi M, Tejpar S (2010) Lancet Oncol. 11:753\u2013762","journal-title":"Lancet Oncol."},{"key":"19_CR17","doi-asserted-by":"publisher","first-page":"5705","DOI":"10.1200\/JCO.2008.18.0786","volume":"26","author":"F Nicolantonio Di","year":"2008","unstructured":"Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, De Dosso S, Mazzucchelli L, Frattini M, Siena S, Bardelli A (2008) J Clin Oncol 26:5705\u20135712","journal-title":"J Clin Oncol"},{"key":"19_CR18","first-page":"147","volume":"1","author":"MF Renzo Di","year":"1995","unstructured":"Di Renzo MF, Olivero M, Giacomini A, Porte H, Chastre E, Mirossay L, Nordlinger B, Bretti S, Bottardi S, Giordano S (1995) Clin Cancer Res 1:147\u2013154","journal-title":"Clin Cancer Res"},{"key":"19_CR19","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1056\/NEJMoa1305275","volume":"369","author":"J-Y Douillard","year":"2013","unstructured":"Douillard J-Y, Oliner KS, Siena S, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Koc\u00e1kova I, Ruff P, B\u0142asi\u0144ska-Morawiec M, \u0160makal M, Canon JL, Rother M, Williams R, Rong A, Wiezorek J, Sidhu R, Patterson SD (2013) N Engl J Med 369:1023\u20131034","journal-title":"N Engl J Med"},{"key":"19_CR20","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.4161\/cbt.26340","volume":"14","author":"C Esposito","year":"2013","unstructured":"Esposito C, Rachiglio AM, La Porta ML, Sacco A, Roma C, Iannaccone A, Tatangelo F, Forgione L, Pasquale R, Barbaro A, Botti G, Ciardiello F, Normanno N (2013) Cancer Biol Ther 14:1143\u20131146","journal-title":"Cancer Biol Ther"},{"key":"19_CR21","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/bjc.2012.581","volume":"108","author":"R Fisher","year":"2013","unstructured":"Fisher R, Pusztai L, Swanton C (2013) Br J Cancer 108:479\u2013485","journal-title":"Br J Cancer"},{"key":"19_CR22","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1016\/S1470-2045(14)70330-4","volume":"15","author":"V Heinemann","year":"2014","unstructured":"Heinemann V, von Weikersthal LF, Decker T, Kiani A, Vehling-Kaiser U, Al-Batran S-E, Heintges T, Lerchenm\u00fcller C, Kahl C, Seipelt G, Kullmann F, Stauch M, Scheithauer W, Hielscher J, Scholz M, M\u00fcller S, Link H, Niederle N, Rost A, H\u00f6ffkes H-G, Moehler M, Lindig RU, Modest DP, Rossius L, Kirchner T, Jung A, Stintzing S (2014) Lancet Oncol 15:1065\u20131075","journal-title":"Lancet Oncol"},{"key":"19_CR23","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1038\/bjc.2014.483","volume":"111","author":"B Ingold Heppner","year":"2014","unstructured":"Ingold Heppner B, Behrens H-M, Balschun K, Haag J, Kr\u00fcger S, Becker T, R\u00f6cken C (2014) Br J Cancer 111:1977\u20131984","journal-title":"Br J Cancer"},{"key":"19_CR24","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1016\/j.ccr.2013.04.012","volume":"23","author":"BS Jaiswal","year":"2013","unstructured":"Jaiswal BS, Kljavin NM, Stawiski EW, Chan E, Parikh C, Durinck S, Chaudhuri S, Pujara K, Guillory J, Edgar KA, Janakiraman V, Scholz R-P, Bowman KK, Lorenzo M, Li H, Wu J, Yuan W, Peters BA, Kan Z, Stinson J, Mak M, Modrusan Z, Eigenbrot C, Firestein R, Stern HM, Rajalingam K, Schaefer G, Merchant MA, Sliwkowski MX, de Sauvage FJ, Seshagiri S (2013) Cancer Cell 23:603\u2013617","journal-title":"Cancer Cell"},{"key":"19_CR25","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1158\/2159-8290.CD-14-1211","volume":"5","author":"SM Kavuri","year":"2015","unstructured":"Kavuri SM, Jain N, Galimi F, Cottino F, Leto SM, Migliardi G, Searleman AC, Shen W, Monsey J, Trusolino L, Jacobs SA, Bertotti A, Bose R (2015) Cancer Discov 5:832\u2013841","journal-title":"Cancer Discov"},{"key":"19_CR26","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1200\/jco.2016.34.4_suppl.642","volume":"34","author":"TW Kim","year":"2016","unstructured":"Kim TW, Elme A, Kusic Z, Park JO, Udrea AA, Kim SY, Ahn JB, Villalobos Valencia R, Srinivasan K, Bilic A, Manojlovic N, Dong J, Guan X, Lofton-Day C, Jung AS, Vrdoljak E (2016) J Clin Oncol 34:642\u2013642","journal-title":"J Clin Oncol"},{"key":"19_CR27","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00109-014-1161-2","volume":"92","author":"SM Leto","year":"2014","unstructured":"Leto SM, Trusolino L (2014) J Mol Med Berl Ger 92:709\u2013722","journal-title":"J Mol Med Berl Ger"},{"key":"19_CR28","doi-asserted-by":"publisher","first-page":"3992","DOI":"10.1158\/0008-5472.CAN-06-0191","volume":"66","author":"A Li\u00e8vre","year":"2006","unstructured":"Li\u00e8vre A, Bachet J-B, Le Corre D, Boige V, Landi B, Emile J-F, C\u00f4t\u00e9 J-F, Tomasic G, Penna C, Ducreux M, Rougier P, Penault-Llorca F, Laurent-Puig P (2006) Cancer Res 66:3992\u20133995","journal-title":"Cancer Res"},{"key":"19_CR29","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1158\/1078-0432.CCR-10-0568","volume":"17","author":"D Liska","year":"2011","unstructured":"Liska D, Chen C-T, Bachleitner-Hofmann T, Christensen JG, Weiser MR (2011) Clin Cancer Res 17:472\u2013482","journal-title":"Clin Cancer Res"},{"key":"19_CR30","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/bjc.2013.4","volume":"108","author":"V Martin","year":"2013","unstructured":"Martin V, Landi L, Molinari F, Fountzilas G, Geva R, Riva A, Saletti P, De Dosso S, Spitale A, Tejpar S, Kalogeras KT, Mazzucchelli L, Frattini M, Cappuzzo F (2013) Br J Cancer 108:668\u2013675","journal-title":"Br J Cancer"},{"key":"19_CR31","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1038\/nature11156","volume":"486","author":"S Misale","year":"2012","unstructured":"Misale S, Yaeger R, Hobor S, Scala E, Janakiraman M, Liska D, Valtorta E, Schiavo R, Buscarino M, Siravegna G, Bencardino K, Cercek A, Chen C-T, Veronese S, Zanon C, Sartore-Bianchi A, Gambacorta M, Gallicchio M, Vakiani E, Boscaro V, Medico E, Weiser M, Siena S, Di Nicolantonio F, Solit D, Bardelli A (2012) Nature 486:532\u2013536","journal-title":"Nature"},{"key":"19_CR32","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1158\/2159-8290.CD-14-0462","volume":"4","author":"S Misale","year":"2014","unstructured":"Misale S, Di Nicolantonio F, Sartore-Bianchi A, Siena S, Bardelli A (2014) Cancer Discov 4:1269\u20131280","journal-title":"Cancer Discov"},{"key":"19_CR33","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/nm.2609","volume":"18","author":"C Montagut","year":"2012","unstructured":"Montagut C, Dalmases A, Bellosillo B, Crespo M, Pairet S, Iglesias M, Salido M, Gallen M, Marsters S, Tsai SP, Minoche A, Seshagiri S, Somasekar S, Serrano S, Himmelbauer H, Bellmunt J, Rovira A, Settleman J, Bosch F, Albanell J (2012) Nat Med 18:221\u2013223","journal-title":"Nat Med"},{"key":"19_CR34","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S1470-2045(05)70102-9","volume":"6","author":"M Moroni","year":"2005","unstructured":"Moroni M, Veronese S, Benvenuti S, Marrapese G, Sartore-Bianchi A, Di Nicolantonio F, Gambacorta M, Siena S, Bardelli A (2005) Lancet Oncol 6:279\u2013286","journal-title":"Lancet Oncol"},{"key":"19_CR35","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1007\/s11523-008-0073-x","volume":"3","author":"M Moroni","year":"2008","unstructured":"Moroni M, Veronese S, Sartore-Bianchi A, Artale S, Siena S (2008) Target Oncol 3:127\u2013130","journal-title":"Target Oncol"},{"key":"19_CR36","doi-asserted-by":"publisher","first-page":"ii109","DOI":"10.1093\/annonc\/mdu193.11","volume":"25","author":"K Newhall","year":"2014","unstructured":"Newhall K, Price T, Peeters M, Kim TW, Li J, Cascinu S, Ruff P, Suresh AS, Thomas A, Tjulandin S, Ogbagabriel S, Boedigheimer M, Sexson S, Zhang K, Murugappan S, Sidhu R (2014) Ann Oncol 25:ii109","journal-title":"Ann Oncol"},{"key":"19_CR37","doi-asserted-by":"publisher","first-page":"1560","DOI":"10.1158\/0008-5472.CAN-14-1590","volume":"75","author":"M Nunes","year":"2015","unstructured":"Nunes M, Vrignaud P, Vacher S, Richon S, Li\u00e8vre A, Cacheux W, Weiswald L-B, Massonnet G, Chateau-Joubert S, Nicolas A, Dib C, Zhang W, Watters J, Bergstrom D, Roman-Roman S, Bi\u00e8che I, Dangles-Marie V (2015) Cancer Res 75:1560\u20131566","journal-title":"Cancer Res"},{"key":"19_CR38","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1007\/s00384-006-0192-8","volume":"22","author":"DI Park","year":"2007","unstructured":"Park DI, Kang MS, Oh SJ, Kim HJ, Cho YK, Sohn CI, Jeon WK, Kim BI, Han WK, Kim H, Ryu SH, Sepulveda AR (2007) Int J Color Dis 22:491\u2013497","journal-title":"Int J Color Dis"},{"key":"19_CR39","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1016\/j.ejca.2015.05.017","volume":"51","author":"M Peeters","year":"2015","unstructured":"Peeters M, Kafatos G, Taylor A, Gastanaga VM, Oliner KS, Hechmati G, Terwey J-H, van Krieken JH (2015) Eur J Cancer Oxford Engl 51:1704\u20131713","journal-title":"Eur J Cancer Oxford Engl"},{"key":"19_CR40","doi-asserted-by":"publisher","first-page":"5869","DOI":"10.1158\/1078-0432.CCR-08-0449","volume":"14","author":"N Personeni","year":"2008","unstructured":"Personeni N, Fieuws S, Piessevaux H, De Hertogh G, De Schutter J, Biesmans B, De Roock W, Capoen A, Debiec-Rychter M, Van Laethem J-L, Peeters M, Humblet Y, Van Cutsem E, Tejpar S (2008) Clin Cancer Res 14:5869\u20135876","journal-title":"Clin Cancer Res"},{"key":"19_CR41","doi-asserted-by":"publisher","first-page":"2457","DOI":"10.1158\/0008-5472.CAN-11-2612","volume":"72","author":"IA Prior","year":"2012","unstructured":"Prior IA, Lewis PD, Mattos C (2012) Cancer Res 72:2457\u20132467","journal-title":"Cancer Res"},{"key":"19_CR42","doi-asserted-by":"publisher","first-page":"54627","DOI":"10.18632\/oncotarget.10559","volume":"7","author":"K Raghav","year":"2016","unstructured":"Raghav K, Morris V, Tang C, Morelli P, Amin HM, Chen K, Manyam GC, Broom B, Overman MJ, Shaw K, Meric-Bernstam F, Maru D, Menter D, Ellis LM, Eng C, Hong D, Kopetz S (2016) Oncotarget 7:54627\u201354631","journal-title":"Oncotarget"},{"key":"19_CR43","doi-asserted-by":"publisher","first-page":"5931","DOI":"10.1200\/JCO.2009.22.4295","volume":"27","author":"SD Richman","year":"2009","unstructured":"Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, Taylor G, Barrett JH, Quirke P (2009) J Clin Oncol 27:5931\u20135937","journal-title":"J Clin Oncol"},{"key":"19_CR44","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1002\/path.4679","volume":"238","author":"SD Richman","year":"2016","unstructured":"Richman SD, Southward K, Chambers P, Cross D, Barrett J, Hemmings G, Taylor M, Wood H, Hutchins G, Foster JM, Oumie A, Spink KG, Brown SR, Jones M, Kerr D, Handley K, Gray R, Seymour M, Quirke P (2016) J Pathol 238:562\u2013570","journal-title":"J Pathol"},{"key":"19_CR45","doi-asserted-by":"publisher","first-page":"1888","DOI":"10.1038\/bjc.2015.173","volume":"112","author":"A Rowland","year":"2015","unstructured":"Rowland A, Dias MM, Wiese MD, Kichenadasse G, McKinnon RA, Karapetis CS, Sorich MJ (2015) Br J Cancer 112:1888\u20131894","journal-title":"Br J Cancer"},{"key":"19_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047054","volume":"7","author":"G Safaee Ardekani","year":"2012","unstructured":"Safaee Ardekani G, Jafarnejad SM, Tan L, Saeedi A, Li G (2012) PLoS One 7:e47054","journal-title":"PLoS One"},{"key":"19_CR47","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1200\/JCO.2004.10.182","volume":"22","author":"LB Saltz","year":"2004","unstructured":"Saltz LB, Meropol NJ, Loehrer PJ, Needle MN, Kopit J, Mayer RJ (2004) J Clin Oncol 22:1201\u20131208","journal-title":"J Clin Oncol"},{"key":"19_CR48","doi-asserted-by":"publisher","first-page":"3260","DOI":"10.1158\/1078-0432.CCR-15-2400","volume":"22","author":"FJ S\u00e1nchez-Mart\u00edn","year":"2016","unstructured":"S\u00e1nchez-Mart\u00edn FJ, Bellosillo B, Gelabert-Baldrich M, Dalmases A, Ca\u00f1adas I, Vidal J, Martinez A, Argil\u00e9s G, Siravegna G, Arena S, Koefoed K, Visa L, Arp\u00ed O, Horak ID, Iglesias M, Stroh C, Kragh M, Rovira A, Albanell J, Tabernero J, Bardelli A, Montagut C (2016) Clin Cancer Res 22:3260\u20133267","journal-title":"Clin Cancer Res"},{"key":"19_CR49","doi-asserted-by":"publisher","first-page":"3238","DOI":"10.1200\/JCO.2007.11.5956","volume":"25","author":"A Sartore-Bianchi","year":"2007","unstructured":"Sartore-Bianchi A, Moroni M, Veronese S, Carnaghi C, Bajetta E, Luppi G, Sobrero A, Barone C, Cascinu S, Colucci G, Cortesi E, Nichelatti M, Gambacorta M, Siena S (2007) J Clin Oncol 25:3238\u20133245","journal-title":"J Clin Oncol"},{"key":"19_CR50","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1136\/jclinpath-2011-200353","volume":"65","author":"A Sartore-Bianchi","year":"2012","unstructured":"Sartore-Bianchi A, Fieuws S, Veronese S, Moroni M, Personeni N, Frattini M, Torri V, Cappuzzo F, Vander Borght S, Martin V, Skokan M, Santoro A, Gambacorta M, Tejpar S, Varella-Garcia M, Siena S (2012) J Clin Pathol 65:218\u2013223","journal-title":"J Clin Pathol"},{"key":"19_CR51","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1093\/annonc\/mdw191","volume":"27","author":"A Sartore-Bianchi","year":"2016","unstructured":"Sartore-Bianchi A, Loupakis F, Argil\u00e9s G, Prager GW (2016a) Ann. Oncol 27:1456\u20131466","journal-title":"Ann. Oncol"},{"key":"19_CR52","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.ctrv.2016.10.006","volume":"51","author":"A Sartore-Bianchi","year":"2016","unstructured":"Sartore-Bianchi A, Siena S, Tonini G, Bardelli A, Santini D (2016b) Cancer Treat Rev 51:54\u201362","journal-title":"Cancer Treat Rev"},{"key":"19_CR53","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/S1470-2045(16)00150-9","volume":"17","author":"A Sartore-Bianchi","year":"2016","unstructured":"Sartore-Bianchi A, Trusolino L, Martino C, Bencardino K, Lonardi S, Bergamo F, Zagonel V, Leone F, Depetris I, Martinelli E, Troiani T, Ciardiello F, Racca P, Bertotti A, Siravegna G, Torri V, Amatu A, Ghezzi S, Marrapese G, Palmeri L, Valtorta E, Cassingena A, Lauricella C, Vanzulli A, Regge D, Veronese S, Comoglio PM, Bardelli A, Marsoni S, Siena S (2016c) Lancet Oncol 17:738\u2013746","journal-title":"Lancet Oncol"},{"key":"19_CR54","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2016-000079","volume":"1","author":"A Sartore-Bianchi","year":"2016","unstructured":"Sartore-Bianchi A, Valtorta E, Amatu A, Veronese S, Lauricella C, Bonazzina E, Siravegna G, Truini M, Bardelli A, Siena S (2016d) ESMO Open 1:e000079","journal-title":"ESMO Open"},{"key":"19_CR55","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1186\/1471-2407-9-303","volume":"9","author":"M Scartozzi","year":"2009","unstructured":"Scartozzi M, Bearzi I, Mandolesi A, Pierantoni C, Loupakis F, Zaniboni A, Negri F, Quadri A, Zorzi F, Galizia E, Berardi R, Biscotti T, Labianca R, Masi G, Falcone A, Cascinu S (2009) BMC Cancer 9:303","journal-title":"BMC Cancer"},{"key":"19_CR56","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1634\/theoncologist.2010-0119","volume":"16","author":"M Scartozzi","year":"2011","unstructured":"Scartozzi M, Mandolesi A, Giampieri R, Bittoni A, Pierantoni C, Zaniboni A, Galizia E, Giustini L, Silva RR, Bisonni R, Berardi R, Biscotti T, Biagetti S, Bearzi I, Cascinu S (2011) Oncologist 16:53\u201360","journal-title":"Oncologist"},{"key":"19_CR57","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.1093\/annonc\/mds236","volume":"23","author":"HJ Schmoll","year":"2012","unstructured":"Schmoll HJ, Van Cutsem E, Stein A, Valentini V, Glimelius B, Haustermans K, Nordlinger B, van de Velde CJ, Balmana J, Regula J, Nagtegaal ID, Beets-Tan RG, Arnold D, Ciardiello F, Hoff P, Kerr D, K\u00f6hne CH, Labianca R, Price T, Scheithauer W, Sobrero A, Tabernero J, Aderka D, Barroso S, Bodoky G, Douillard JY, El Ghazaly H, Gallardo J, Garin A, Glynne-Jones R, Jordan K, Meshcheryakov A, Papamichail D, Pfeiffer P, Souglakos I, Turhal S, Cervantes A (2012) Ann Oncol 23:2479\u20132516","journal-title":"Ann Oncol"},{"key":"19_CR58","doi-asserted-by":"publisher","first-page":"2240","DOI":"10.1200\/JCO.2013.53.2473","volume":"32","author":"LS Schwartzberg","year":"2014","unstructured":"Schwartzberg LS, Rivera F, Karthaus M, Fasola G, Canon J-L, Hecht JR, Yu H, Oliner KS, Go WY (2014) J Clin Oncol 32:2240\u20132247","journal-title":"J Clin Oncol"},{"key":"19_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098528","volume":"9","author":"AN Seo","year":"2014","unstructured":"Seo AN, Kwak Y, Kim D-W, Kang S-B, Choe G, Kim WH, Lee HS (2014) PLoS One 9:e98528","journal-title":"PLoS One"},{"key":"19_CR60","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3322\/caac.21387","volume":"67","author":"RL Siegel","year":"2017","unstructured":"Siegel RL, Miller KD, Jemal A (2017) CA Cancer J Clin 67:7\u201330","journal-title":"CA Cancer J Clin"},{"key":"19_CR61","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1038\/nm.3870","volume":"21","author":"G Siravegna","year":"2015","unstructured":"Siravegna G, Mussolin B, Buscarino M, Corti G, Cassingena A, Crisafulli G, Ponzetti A, Cremolini C, Amatu A, Lauricella C, Lamba S, Hobor S, Avallone A, Valtorta E, Rospo G, Medico E, Motta V, Antoniotti C, Tatangelo F, Bellosillo B, Veronese S, Budillon A, Montagut C, Racca P, Marsoni S, Falcone A, Corcoran RB, Di Nicolantonio F, Loupakis F, Siena S, Sartore-Bianchi A, Bardelli A (2015) Nat Med 21:795\u2013801","journal-title":"Nat Med"},{"key":"19_CR62","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1093\/annonc\/mdu378","volume":"26","author":"MJ Sorich","year":"2015","unstructured":"Sorich MJ, Wiese MD, Rowland A, Kichenadasse G, McKinnon RA, Karapetis CS (2015) Ann Oncol 26:13\u201321","journal-title":"Ann Oncol"},{"key":"19_CR63","doi-asserted-by":"publisher","first-page":"1289","DOI":"10.1056\/NEJMsb1607705","volume":"375","author":"IF Tannock","year":"2016","unstructured":"Tannock IF, Hickman JA (2016) N Engl J Med 375:1289\u20131294","journal-title":"N Engl J Med"},{"key":"19_CR64","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1038\/nm.3511","volume":"20","author":"AR Thierry","year":"2014","unstructured":"Thierry AR, Mouliere F, El Messaoudi S, Mollevi C, Lopez-Crapez E, Rolet F, Gillet B, Gongora C, Dechelotte P, Robert B, Del Rio M, Lamy P-J, Bibeau F, Nouaille M, Loriot V, Jarrousse A-S, Molina F, Mathonnet M, Pezet D, Ychou M (2014) Nat Med 20:430\u2013435","journal-title":"Nat Med"},{"key":"19_CR65","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1038\/nrm3012","volume":"11","author":"L Trusolino","year":"2010","unstructured":"Trusolino L, Bertotti A, Comoglio PM (2010) Nat Rev Mol Cell Biol 11:834\u2013848","journal-title":"Nat Rev Mol Cell Biol"},{"key":"19_CR66","doi-asserted-by":"publisher","first-page":"6443","DOI":"10.1158\/0008-5472.CAN-16-2867","volume":"76","author":"T Ushijima","year":"2016","unstructured":"Ushijima T, Yoshino T (2016) Cancer Res 76:6443\u20136444","journal-title":"Cancer Res"},{"key":"19_CR67","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1002\/ijc.28106","volume":"133","author":"E Valtorta","year":"2013","unstructured":"Valtorta E, Misale S, Sartore-Bianchi A, Nagtegaal ID, Paraf F, Lauricella C, Dimartino V, Hobor S, Jacobs B, Ercolani C, Lamba S, Scala E, Veronese S, Laurent-Puig P, Siena S, Tejpar S, Mottolese M, Punt CJA, Gambacorta M, Bardelli A, Di Nicolantonio F (2013) Int J Cancer 133:1259\u20131265","journal-title":"Int J Cancer"},{"key":"19_CR68","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/modpathol.2015.98","volume":"28","author":"E Valtorta","year":"2015","unstructured":"Valtorta E, Martino C, Sartore-Bianchi A, Penaullt-Llorca F, Viale G, Risio M, Rugge M, Grigioni W, Bencardino K, Lonardi S, Zagonel V, Leone F, Noe J, Ciardiello F, Pinto C, Labianca R, Mosconi S, Graiff C, Aprile G, Frau B, Garufi C, Loupakis F, Racca P, Tonini G, Lauricella C, Veronese S, Truini M, Siena S, Marsoni S, Gambacorta M (2015) Mod Pathol 28:1481\u20131491","journal-title":"Mod Pathol"},{"key":"19_CR69","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1200\/JCO.2010.33.5091","volume":"29","author":"E Cutsem Van","year":"2011","unstructured":"Van Cutsem E, K\u00f6hne C-H, L\u00e1ng I, Folprecht G, Nowacki MP, Cascinu S, Shchepotin I, Maurel J, Cunningham D, Tejpar S, Schlichting M, Zubel A, Celik I, Rougier P, Ciardiello F (2011) J Clin Oncol 29:2011\u20132019","journal-title":"J Clin Oncol"},{"key":"19_CR70","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1200\/JCO.2014.59.4812","volume":"33","author":"E Cutsem Van","year":"2015","unstructured":"Van Cutsem E, Lenz H-J, K\u00f6hne C-H, Heinemann V, Tejpar S, Melez\u00ednek I, Beier F, Stroh C, Rougier P, van Krieken JH, Ciardiello F (2015) J Clin Oncol 33:692\u2013700","journal-title":"J Clin Oncol"},{"key":"19_CR71","doi-asserted-by":"publisher","first-page":"1386","DOI":"10.1093\/annonc\/mdw235","volume":"27","author":"E Cutsem Van","year":"2016","unstructured":"Van Cutsem E, Cervantes A, Adam R, Sobrero A, Van Krieken JH, Aderka D, Aranda Aguilar E, Bardelli A, Benson A, Bodoky G, Ciardiello F, D\u2019Hoore A, Diaz-Rubio E, Douillard J-Y, Ducreux M, Falcone A, Grothey A, Gruenberger T, Haustermans K, Heinemann V, Hoff P, K\u00f6hne C-H, Labianca R, Laurent-Puig P, Ma B, Maughan T, Muro K, Normanno N, \u00d6sterlund P, Oyen WJG, Papamichael D, Pentheroudakis G, Pfeiffer P, Price TJ, Punt C, Ricke J, Roth A, Salazar R, Scheithauer W, Schmoll HJ, Tabernero J, Ta\u00efeb J, Tejpar S, Wasan H, Yoshino T, Zaanan A, Arnold D (2016) Ann Oncol 27:1386\u20131422","journal-title":"Ann Oncol"},{"key":"19_CR72","doi-asserted-by":"publisher","first-page":"1084","DOI":"10.1016\/j.molonc.2014.05.003","volume":"8","author":"BO Emburgh Van","year":"2014","unstructured":"Van Emburgh BO, Sartore-Bianchi A, Di Nicolantonio F, Siena S, Bardelli A (2014) Mol Oncol 8:1084\u20131094","journal-title":"Mol Oncol"},{"key":"19_CR73","doi-asserted-by":"publisher","first-page":"13665","DOI":"10.1038\/ncomms13665","volume":"7","author":"BO Emburgh Van","year":"2016","unstructured":"Van Emburgh BO, Arena S, Siravegna G, Lazzari L, Crisafulli G, Corti G, Mussolin B, Baldi F, Buscarino M, Bartolini A, Valtorta E, Vidal J, Bellosillo B, Germano G, Pietrantonio F, Ponzetti A, Albanell J, Siena S, Sartore-Bianchi A, Di Nicolantonio F, Montagut C, Bardelli A (2016) Nat Commun 7:13665","journal-title":"Nat Commun"},{"key":"19_CR74","doi-asserted-by":"publisher","first-page":"5s","DOI":"10.1200\/jco.2014.32.15_suppl.lba3","volume":"32","author":"AP Venook","year":"2014","unstructured":"Venook AP, Niedzwiecki D, Lenz H-J, Innocenti F, Mahoney MR, O\u2019Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Mayer RJ, Schilsky RL, Bertagnolli MM, Blanke CD, Alliance CLGB, SWOG, ECOG (2014) J Clin Oncol 32:5s","journal-title":"J Clin Oncol"},{"key":"19_CR75","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1126\/science.1235122","volume":"339","author":"B Vogelstein","year":"2013","unstructured":"Vogelstein B, Papadopoulos N, Velculescu VE, Zhou S, Diaz LA, Kinzler KW (2013) Science 339:1546\u20131558","journal-title":"Science"},{"key":"19_CR76","doi-asserted-by":"publisher","first-page":"99ra86","DOI":"10.1126\/scitranslmed.3002442","volume":"3","author":"K Yonesaka","year":"2011","unstructured":"Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, Ercan D, Rogers A, Roncalli M, Takeda M, Fujisaka Y, Philips J, Shimizu T, Maenishi O, Cho Y, Sun J, Destro A, Taira K, Takeda K, Okabe T, Swanson J, Itoh H, Takada M, Lifshits E, Okuno K, Engelman JA, Shivdasani RA, Nishio K, Fukuoka M, Varella-Garcia M, Nakagawa K, J\u00e4nne PA (2011) Sci Transl Med 3:99ra86","journal-title":"Sci Transl Med"},{"key":"19_CR77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0065995","volume":"8","author":"Z-X Yuan","year":"2013","unstructured":"Yuan Z-X, Wang X-Y, Qin Q-Y, Chen D-F, Zhong Q-H, Wang L, Wang J-P (2013) PLoS One 8:e65995","journal-title":"PLoS One"},{"key":"19_CR78","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.canlet.2008.02.049","volume":"265","author":"Z-S Zeng","year":"2008","unstructured":"Zeng Z-S, Weiser MR, Kuntz E, Chen C-T, Khan SA, Forslund A, Nash GM, Gimbel M, Yamaguchi Y, Culliford AT, D\u2019Alessio M, Barany F, Paty PB (2008) Cancer Lett 265:258\u2013269","journal-title":"Cancer Lett"}],"container-title":["Handbook of Experimental Pharmacology","Mechanisms of Drug Resistance in Cancer Therapy"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2017_19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T07:00:47Z","timestamp":1658905247000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/164_2017_19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783030105068","9783030105075"],"references-count":78,"URL":"https:\/\/doi.org\/10.1007\/164_2017_19","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"type":"print","value":"0171-2004"},{"type":"electronic","value":"1865-0325"}],"subject":[],"published":{"date-parts":[[2017]]}}}