{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:28:16Z","timestamp":1768476496019,"version":"3.49.0"},"publisher-location":"Cham","reference-count":142,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783319902838","type":"print"},{"value":"9783319902845","type":"electronic"}],"license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017]]},"DOI":"10.1007\/164_2017_43","type":"book-chapter","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T09:15:16Z","timestamp":1506762916000},"page":"331-354","source":"Crossref","is-referenced-by-count":35,"title":["Cardiac Arrhythmias Related to Sodium Channel Dysfunction"],"prefix":"10.1007","author":[{"given":"Eleonora","family":"Savio-Galimberti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Antzelevitch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,10,1]]},"reference":[{"issue":"3","key":"43_CR1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1161\/CIRCEP.113.001340","volume":"7","author":"K Abe","year":"2014","unstructured":"Abe K et al (2014) Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. Circ Arrhythm Electrophysiol 7(3):511\u2013517","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"43_CR2","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1001\/jama.286.18.2264","volume":"286","author":"MJ Ackerman","year":"2001","unstructured":"Ackerman MJ, Siu BL, Sturner WQ et al (2001) Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome. JAMA 286:2264\u20132269","journal-title":"JAMA"},{"key":"43_CR125","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1161\/01.RES.0000229244.97497.2c","volume":"98","author":"M Allouis","year":"2006","unstructured":"Allouis M, Le Bouffant F, Wilders R, Peroz D, Schott JJ, Noireaud J, Le Marec H, Merot J, Escnade D, Baro I (2006) 14-3-3 is a regulator of the cardiac voltage-gated sodium channel Nav1.5. Circ Res 98:1538\u20131546","journal-title":"Circ Res"},{"issue":"5","key":"43_CR3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1053\/euhj.2000.2461","volume":"22","author":"C Antzelevitch","year":"2001","unstructured":"Antzelevitch C (2001) The Brugada syndrome: diagnostic criteria and cellular mechanisms. Eur Heart J 22(5):356\u2013363","journal-title":"Eur Heart J"},{"issue":"7 Pt 1","key":"43_CR4","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1046\/j.1460-9592.2003.t01-1-00206.x","volume":"26","author":"C Antzelevitch","year":"2003","unstructured":"Antzelevitch C (2003) Androgens and male predominance of the Brugada syndrome phenotype. Pacing Clin Electrophysiol 26(7 Pt 1):1429\u20131431","journal-title":"Pacing Clin Electrophysiol"},{"issue":"s4","key":"43_CR5","first-page":"iv4","volume":"9","author":"C Antzelevitch","year":"2007","unstructured":"Antzelevitch C (2007a) Ionic, molecular, and cellular bases of QT-interval prolongation and torsade de pointes. Europace 9(s4):iv4\u2013iv15","journal-title":"Europace"},{"issue":"4","key":"43_CR6","doi-asserted-by":"crossref","first-page":"H2024","DOI":"10.1152\/ajpheart.00355.2007","volume":"293","author":"C Antzelevitch","year":"2007","unstructured":"Antzelevitch C (2007b) The role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol 293(4):H2024\u2013H2038","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"43_CR7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.hrthm.2009.12.006","volume":"7","author":"C Antzelevitch","year":"2010","unstructured":"Antzelevitch C, Yan GX (2010) J wave syndromes. Heart Rhythm 7(4):549\u2013558","journal-title":"Heart Rhythm"},{"issue":"8","key":"43_CR8","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/j.hrthm.2015.04.014","volume":"12","author":"C Antzelevitch","year":"2015","unstructured":"Antzelevitch C, Yan GX (2015) J wave syndrome: Brugada and early repolarization syndromes. Heart Rhythm 12(8):1852\u20131866","journal-title":"Heart Rhythm"},{"key":"43_CR9","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-642-41588-3_7","volume":"221","author":"C Antzelevitch","year":"2014","unstructured":"Antzelevitch C, Nesterenko V, Shryock JC, Rajamani S, Song Y, Belardinelli L (2014) The role of late I\nNa in development of cardiac arrhythmias. Handb Exp Pharmacol 221:137\u2013168","journal-title":"Handb Exp Pharmacol"},{"issue":"10","key":"43_CR10","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1016\/j.hrthm.2016.05.024","volume":"13","author":"C Antzelevitch","year":"2016","unstructured":"Antzelevitch C, Yan GX, Ackerman MJ, Borggrefe M, Corrado D, Guo J, Gussak I, Hasdemir C, Horie M, Huikuri H, Ma C, Morita H, Nam GB, Sacher F, Shimizu W, Viskin S, Wilde AA (2016) J-wave syndromes expert consensus conference report: emerging concepts and gaps in knowledge. Heart Rhythm 13(10):e295\u2013e324","journal-title":"Heart Rhythm"},{"issue":"2","key":"43_CR11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1161\/CIRCOUTCOMES.108.798009","volume":"1","author":"SV Arnold","year":"2008","unstructured":"Arnold SV, Morrow DA, Wang K, Lei Y, Mahoney EM, Scirica BM, Braunwald E, Cohen DJ, Investigators M-T (2008) Effects of ranolazine on disease-specific health status and quality of life among patients with acute coronary syndromes results from the MERLIN-TIMI 36 randomized trial. Circ Cardiovasc Qual Outcomes 1(2):107\u2013115","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"43_CR12","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1172\/JCI62617","volume":"122","author":"DE Arnolds","year":"2012","unstructured":"Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP (2012) TBX5 drives Scn5a expression to regulate cardiac conduction system function. J Clin Invest 122:2509\u20132518","journal-title":"J Clin Invest"},{"key":"43_CR126","doi-asserted-by":"crossref","first-page":"19856","DOI":"10.1074\/jbc.M111.322537","volume":"287","author":"NM Ashpole","year":"2012","unstructured":"Ashpole NM, Herren AW, Ginsburg KS, Brogan JD, Johnson DE, Cummins TR, Bers DM, Hudmon A (2012) Ca2+\/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel Nav1.5 gating by multiple phosphorylation sites. J Biol Chem 287:19856\u201319869","journal-title":"J Biol Chem"},{"issue":"1","key":"43_CR13","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nn.2694","volume":"14","author":"SM Baig","year":"2011","unstructured":"Baig SM, Koschak A, Lieb A, Gebhart M, Dafinger C, Nurnberg G, Ali A, Ahmad I, Sinnegger-Brauns MJ, Brandt N, Engel J, Mangoni ME, Farooq M, Khan HU, Nurnberg P, Striessnig J, Bolz HJ (2011) Loss of Ca(v)1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness. Nat Neurosci 14(1):77\u201384","journal-title":"Nat Neurosci"},{"issue":"1","key":"43_CR14","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/cvr\/cvn255","volume":"81","author":"H Barajas-Martinez","year":"2009","unstructured":"Barajas-Martinez H, Haufe V, Chamberland C, Blais Roy MJ, Fecteau MH, Cordeiro JM, Dumaine R (2009) Larger dispersion of INa in female dog ventricle as a mechanism for gender-specific incidence of cardiac arrhythmias. Cardiovasc Res 81(1):82\u201389","journal-title":"Cardiovasc Res"},{"key":"43_CR15","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ccep.2014.07.001","volume":"6","author":"J Barc","year":"2014","unstructured":"Barc J, Bezzina C (2014) Role of rare and common genetic variation in SCN5A in cardiac electrical function and arrhythmia. Card Electrophysiol Clin 6:665\u2013677","journal-title":"Card Electrophysiol Clin"},{"issue":"1","key":"43_CR16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/HCO.0000000000000134","volume":"30","author":"AE Baruteau","year":"2015","unstructured":"Baruteau AE, Probst V, Abriel H (2015) Inherited progressive cardiac conduction disorders. Curr Opin Cardiol 30(1):33\u201339","journal-title":"Curr Opin Cardiol"},{"issue":"683\u2013685","key":"43_CR17","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/376683a0","volume":"376","author":"PB Bennett","year":"1995","unstructured":"Bennett PB, Yazawa K, Makita N, George AL Jr (1995) Molecular mechanism for an inherited cardiac arrhythmia. Nature 376(683\u2013685):683","journal-title":"Nature"},{"key":"43_CR18","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI200318062","volume":"112","author":"DW Benson","year":"2003","unstructured":"Benson DW, Wang DW, Dyment M, Knilans TK, Fish FA, Strieper MJ, Rhodes TH, George AL Jr (2003) Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A). J Clin Invest 112:1019\u20131028","journal-title":"J Clin Invest"},{"key":"43_CR19","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1161\/CIRCULATIONAHA.105.580811","volume":"113","author":"CR Bezzina","year":"2006","unstructured":"Bezzina CR, Shimizu W, Yang P, Koopmann TT, Tanck MWT, Miyamoto Y, Kamakura S, Roden DM, Wilde AAM (2006) Common sodium channel promoter haplotype is asian subjects underlies variability in cardiac conduction. Circulation 113:338\u2013344","journal-title":"Circulation"},{"issue":"3","key":"43_CR20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.tcm.2013.09.001","volume":"24","author":"M Boogaard van den","year":"2014","unstructured":"van den Boogaard M, Barnett P, Christoffels VM (2014) From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning. Trends Cardiovasc Med 24(3):99\u2013104","journal-title":"Trends Cardiovasc Med"},{"key":"43_CR21","unstructured":"Brugada R, Kaab S (2008) Atrial fibrillation: from bench to bedside. In: Natale A, Jalife J (eds) Chapter 6 Humana Press, Totowa, NJ, pp 69\u201376"},{"issue":"1","key":"43_CR22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1161\/CIRCRESAHA.110.219949","volume":"107","author":"TD Butters","year":"2010","unstructured":"Butters TD, Aslanidi OV, Inada S, Boyett MR, Hancox JC, Lei M, Zhang H (2010) Mechanistic links between Na+ channel (SCN5A) mutations and impaired cardiac pacemaking in sick sinus syndrome. Circ Res 107(1):126\u2013137","journal-title":"Circ Res"},{"issue":"1","key":"43_CR23","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1113\/expphysiol.2013.071969","volume":"99","author":"W Catterall","year":"2014","unstructured":"Catterall W (2014) Structure and function of voltage-gated sodium channels at atomic resolution. Exp Physiol 99(1):35\u201351","journal-title":"Exp Physiol"},{"issue":"4","key":"43_CR24","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1124\/pr.57.4.5","volume":"57","author":"WA Catterall","year":"2005","unstructured":"Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (2005) International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels. Pharmacol Rev 57(4):411\u2013425","journal-title":"Pharmacol Rev"},{"key":"43_CR25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ng.516","volume":"42","author":"JC Chambers","year":"2010","unstructured":"Chambers JC, Zhao J, Terraciano CMN, Bezzina CR, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi JS, Kooner MK, Deng G, Siedlecka U, Parasramka S, El-Hamamsy I, Wass MN, Dekker LR, de Jong JS, Sternberg MJ, McKenna W, Severs NJ, de Silva R, Wilde AA, Anand P, Yacoub M, Scott J, Elliott P, Wood JN, Kooner JS (2010) Genetic variation in SCN10A influences cardiac conduction. Nat Genet 42:149\u2013152","journal-title":"Nat Genet"},{"issue":"1","key":"43_CR26","doi-asserted-by":"crossref","first-page":"H154","DOI":"10.1152\/ajpheart.01327.2007","volume":"295","author":"JM Cordeiro","year":"2008","unstructured":"Cordeiro JM, Mazza M, Goodrow R, Ulahannan N, Antzelevitch C, Di Diego JM (2008) Functionally distinct sodium channels in ventricular epicardial and endocardial cells contribute to a greater sensitivity of the epicardium to electrical depression. Am J Physiol Heart Circ Physiol 295(1):H154\u2013H162","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"15","key":"43_CR27","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1161\/CIRCULATIONAHA.107.757955","volume":"117","author":"D Darbar","year":"2008","unstructured":"Darbar D, Kannankeril PJ, Donahue BS, Kucera G, Stubblefield T, Haines JL, George AL Jr, Roden DM (2008) Cardiac sodium channel (SCN5A) variants associated with atrial fibrillation. Circulation 117(15):1927\u20131935","journal-title":"Circulation"},{"key":"43_CR127","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1113\/jphysiol.2010.192559","volume":"588","author":"K Dover","year":"2010","unstructured":"Dover K, Solinas S, D\u2019Angelo E, Goldfarb M (2010) Long-term inactivation particle for voltage-gated sodium channels. J Physiol Lond 588:3695\u20133711","journal-title":"J Physiol Lond"},{"issue":"1","key":"43_CR28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.hrthm.2007.09.015","volume":"5","author":"PT Ellinor","year":"2008","unstructured":"Ellinor PT, Nam EG, Shea MA et al (2008) Cardiac sodium channel mutations in atrial fibrillation. Heart Rhythm 5(1):99\u2013105","journal-title":"Heart Rhythm"},{"issue":"11","key":"43_CR29","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1253\/circj.CJ-10-0221","volume":"74","author":"K Ezaki","year":"2010","unstructured":"Ezaki K, Nakagawa M, Taniguchi Y, Nagano Y, Teshima Y, Yufu K, Takahashi N, Nomura T, Satoh F, Mimata H, Saikawa T (2010) Gender differences in the ST segment: effect of androgen-deprivation therapy and possible role of testosterone. Circ J 74(11):2448\u20132454","journal-title":"Circ J"},{"issue":"3","key":"43_CR30","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1536\/ihj.52.146","volume":"52","author":"P Facer","year":"2011","unstructured":"Facer P, Punjabi PP, Abrari A, Kaba RA, Severs NJ, Chambers J, Kooner JS, Anand P (2011) Localisation of SCN10A gene product Na(v)1.8 and novel pain-related ion channels in human heart. Int Heart J 52(3):146\u2013152","journal-title":"Int Heart J"},{"key":"43_CR31","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1006\/jmbi.2001.5053","volume":"313","author":"T Furukawa","year":"2001","unstructured":"Furukawa T, Ono Y, Tsuchiya H, Katayama Y, Bang ML, Labeit D, Labeit S, Inagaki N, Gregorio CC (2001) Specific interaction of the potassium channel beta subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J Mol Biol 313:775\u2013784","journal-title":"J Mol Biol"},{"key":"43_CR32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0248-4900(03)00091-1","volume":"95","author":"JJ Garrido","year":"2003","unstructured":"Garrido JJ, Fernandes F, Moussif A, Fache MP, Giraud P, Dargent B (2003) Dynamic compartmentalization of the voltage-gated sodium channels in axons. Biol Cell 95:437\u2013445","journal-title":"Biol Cell"},{"key":"43_CR128","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1161\/01.RES.0000237466.13252.5e","volume":"99","author":"B Gavillet","year":"2006","unstructured":"Gavillet B, Rougier JS, Domenighetti AA, Behar R, Boixel C, Ruchat P, Lehr HA, Pedrazzini T, Abriel H (2006) Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin. Circ Res 99:407\u2013414","journal-title":"Circ Res"},{"issue":"2","key":"43_CR33","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1073\/pnas.89.2.554","volume":"89","author":"ME Gellens","year":"1992","unstructured":"Gellens ME, George AL Jr, Chen LQ, Chahine M, Horn R, Barchi RL, Kallen RG (1992a) Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci U S A 89(2):554\u2013558","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"43_CR34","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1073\/pnas.89.2.554","volume":"89","author":"ME Gellens","year":"1992","unstructured":"Gellens ME, George AL Jr, Chen LQ, Chahine M, Horn R, Barchi RL, Kallen RG (1992b) Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel. Proc Natl Acad Sci U S A 89(2):554\u2013558","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1-2","key":"43_CR35","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000133892","volume":"68","author":"AL George Jr","year":"1995","unstructured":"George AL Jr, Varkony T, Drabkin HA, Han J, Knops JF, Finley WH, Brown GB, Ward DC, Haas M (1995) Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel alpha-subunit gene (SCN5A) to band 3p21. Cytogenet Cell Genet 68(1-2):67\u201370","journal-title":"Cytogenet Cell Genet"},{"key":"43_CR36","first-page":"33","volume":"144","author":"PR Greenlee","year":"1986","unstructured":"Greenlee PR, Anderson JL, Lutz JR, Lindsay AE, Hagan AD (1986) Familial automaticity-conduction disorder with associated cardiomyopathy. West J Med 144:33\u201341","journal-title":"West J Med"},{"key":"43_CR37","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ijcard.2017.04.058","volume":"241","author":"L Hategan","year":"2017","unstructured":"Hategan L, Csanyi B, Ordog B, Kakonyi K, Tringer A, Kiss O, Orosz A, Saghy L, Nagy I, Hegedus Z, Rudas L, Szell M, Varro A, Forster T, Sepp R (2017) A novel \u201csplice site\u201d HCN4 gene mutation, c.1737+1 G>T, causes familial bradycardia, reduced heart rate response, impaired chronotropic competence and increased short-term heart rate variability. Int J Cardiol 241:364\u2013372","journal-title":"Int J Cardiol"},{"key":"43_CR38","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1161\/01.RES.0000149299.34793.3c","volume":"95","author":"RS Haworth","year":"2004","unstructured":"Haworth RS, Cuello F, Herron TJ, Franzen G, Kentish JC, Gautel M, Avkiran M (2004) Protein kinase D is a novel mediator of cardiac troponin I phosphorylation and regulates myofilament function. Circ Res 95:1091\u20131099","journal-title":"Circ Res"},{"issue":"5","key":"43_CR39","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1161\/CIRCEP.114.002519","volume":"8","author":"K Hayashi","year":"2015","unstructured":"Hayashi K, Konno T, Tada H, Tani S, Liu L, Fujino N, Nohara A, Hodatsu A, Tsuda T, Tanaka Y, Kawashiri MA, Ino H, Makita N, Yamagishi M (2015) Functional characterization of rare variants implicated in susceptibility to lone atrial fibrillation. Circ Arrhythm Electrophysiol 8(5):1095\u20131104","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"1","key":"43_CR40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1097\/HCO.0000000000000356","volume":"32","author":"K Hayashi","year":"2017","unstructured":"Hayashi K, Tada H, Yamagishi M (2017) The genetics of atrial fibrillation. Curr Opin Cardiol 32(1):10\u201316","journal-title":"Curr Opin Cardiol"},{"issue":"2","key":"43_CR41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/ng.511","volume":"42","author":"H Holm","year":"2010","unstructured":"Holm H, Gudbjartsson D, Arnar DO et al (2010) Several common variants modulate heart rate, PR interval and QRS duration. Nat Genet 42(2):117\u2013122","journal-title":"Nat Genet"},{"issue":"3","key":"43_CR42","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1161\/CIRCGENETICS.108.829192","volume":"2","author":"D Hu","year":"2009","unstructured":"Hu D, Barajas-Martinez H, Burashnikov E, Springer M, Wu Y, Varro A, Pfeiffer R, Koopmann TT, Cordeiro JM, Guerchicoff A, Pollevick GD, Antzelevitch C (2009) A mutation in the beta 3 subunit of the cardiac sodium channel associated with Brugada ECG phenotype. Circ Cardiovasc Genet 2(3):270\u2013278","journal-title":"Circ Cardiovasc Genet"},{"key":"43_CR43","first-page":"S320","volume":"7","author":"D Hu","year":"2010","unstructured":"Hu D, Barajas-Martinez H, Burashnikov E, Pfeiffer R, Schimpf R, Wolpert C, Borggrefe M, Antzelevitch C (2010) A novel mutation in SCN1BB linked to Brugada syndrome by modulating Nav1.5 and KV4.3 current. Heart Rhythm 7:S320","journal-title":"Heart Rhythm"},{"issue":"21 Supplement","key":"43_CR44","first-page":"A16521","volume":"126","author":"D Hu","year":"2012","unstructured":"Hu D, Barajas-Martinez H, Medeiros-Domingo A, Crotti L, Tester DJ, Veltmann C, Schimpf R, Pfeiffer R, Dezi F, Liu Y, Burashnikov E, Giudicessi JR, Ye D, Wolpert C, Borggrefe M, Schwartz P, Ackerman MJ, Antzelevitch C (2012) Novel mutations in the sodium channel 2 subunit gene (SCN2B) associated with Brugada syndrome and atrial fibrillation. Circulation 126(21 Supplement):A16521","journal-title":"Circulation"},{"issue":"1","key":"43_CR45","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jacc.2014.04.032","volume":"64","author":"D Hu","year":"2014","unstructured":"Hu D, Barajas-Martinez H, Pfeiffer R, Dezi F, Pfeiffer J, Buch T, Betzenhauser MJ, Belardinelli L, Kahlig KM, Rajamani S, DeAntonio HJ, Myerburg RJ, Ito H, Deshmukh P, Marieb M, Nam GB, Bhatia A, Hasdemir C, Haissaguerre M, Veltmann C, Schimpf R, Borggrefe M, Viskin S, Antzelevitch C (2014) Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. J Am Coll Cardiol 64(1):66\u201379","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"43_CR46","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1161\/HCG.0000000000000022","volume":"8","author":"J Jabbari","year":"2015","unstructured":"Jabbari J, Olesen MS, Yuan L, Nielsen JB, Liang B, Macri V, Christophersen IE, Nielsen N, Sajadieh A, Ellinor PT, Grunnet M, Haunso S, Holst AG, Svendsen JH, Jespersen T (2015) Common and rare variants in SCN10A modulate the risk of atrial fibrillation. Circ Cardiovasc Genet 8(1):64\u201373","journal-title":"Circ Cardiovasc Genet"},{"key":"43_CR47","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1083\/jcb.200109026","volume":"155","author":"SM Jenkins","year":"2001","unstructured":"Jenkins SM, Bennett V (2001) Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. J Cell Biol 155:739\u2013746","journal-title":"J Cell Biol"},{"key":"43_CR129","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/j.bbrc.2006.08.014","volume":"348","author":"T Jespersen","year":"2006","unstructured":"Jespersen T, Gavillet B, van Bemmelen MX, Cordonier S, Ma T, Staub O, Abriel H (2006) Cardiac sodium channel Nav1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1. Biochem Biophys Res Commun 348:1455\u20131462","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"43_CR48","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.hrthm.2009.09.069","volume":"7","author":"JD Kapplinger","year":"2010","unstructured":"Kapplinger JD, Tester DJ, Alders M, Benito B, Berthet M, Brugada J, Brugada P, Fressart V, Guerchicoff A, Harris-Kerr C, Kamakura S, Kyndt F, Koopmann TT, Miyamoto M, Pfeiffer R, Pollevick GD, Probst V, Zumhagen S, Vatta M, Towbin JA, Shimizu W, Schulze-Bahr E, Antzelevitch C, Salisbury BA, Guicheney P, Wilde AAM, Brugada R, Schott JJ, Ackerman MJ (2010) An international compendium of mutations in the SCN5A encoded cardiac sodium channel in patients referred for Brugada syndrome genetic testing. Heart Rhythm 7(1):33\u201346","journal-title":"Heart Rhythm"},{"key":"43_CR49","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.yjmcc.2013.05.006","volume":"61","author":"SG Kaufmann","year":"2013","unstructured":"Kaufmann SG, Westenbroek R, Maass AH, Lange V, Renner A, Wischmeyer E, Bonz A, Muck J, Ertl G, Catterall WA, Scheuer T, Maier SK (2013) Distribution and function of sodium channel subtypes in human atrial myocardium. J Mol Cell Cardiol 61:133\u2013141","journal-title":"J Mol Cell Cardiol"},{"issue":"8","key":"43_CR50","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMra0803836","volume":"361","author":"HC Kinney","year":"2009","unstructured":"Kinney HC, Thach BT (2009) The sudden infant death syndrome. N Engl J Med 361(8):795\u2013805","journal-title":"N Engl J Med"},{"key":"43_CR51","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S0092-8674(02)01226-6","volume":"111","author":"R Knoll","year":"2002","unstructured":"Knoll R, Hoshijima M, Hoffman MH, Person V, Lorenzen-Schmidt I, Bang ML, Hayashi T, Shiga N, Yasukawa H, Schaper W, McKenna W, Yokoyama M, Schork JN, Omens HJ, McCulloch DA, Kimura A, Gregorio CC, Poller W, Schaper J, Schultheiss HP, Chien KR (2002) The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111:943\u2013955","journal-title":"Cell"},{"key":"43_CR130","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s00424-004-1348-4","volume":"449","author":"SH Ko","year":"2005","unstructured":"Ko SH, Lenkowski PW, Lee HC, Mounsey JP, Patel MK (2005) Modulation of Nav1.5 by beta 1 and beta 3 subunit co-expression in mammalian cells. Pflugers Arch 449:403\u2013412","journal-title":"Pflugers Arch"},{"key":"43_CR52","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.jmb.2004.03.071","volume":"339","author":"S Kojic","year":"2004","unstructured":"Kojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, Valle G, Faulkner G (2004) The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle. J Mol Biol 339:313\u2013325","journal-title":"J Mol Biol"},{"key":"43_CR53","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yjmcc.2011.12.014","volume":"52","author":"IC Kolder","year":"2012","unstructured":"Kolder IC, Tanck MW, Bezzina CR (2012) Common genetic variation modulating cardiac ECG parameters and susceptibility to sudden cardiac death. J Mol Cell Cardiol 52:620\u2013629","journal-title":"J Mol Cell Cardiol"},{"key":"43_CR54","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1540-8167.2006.00411.x","volume":"17","author":"PJ Laitinen-Forsblom","year":"2006","unstructured":"Laitinen-Forsblom PJ, M\u00e4kynen P, M\u00e4kynen H et al (2006) SCN5A mutation associated with cardiac conduction defect and atrial arrhythmias. J Cardiovasc Electrophysiol 17:480\u2013485","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"43_CR55","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jacc.2012.02.052","volume":"60","author":"G Laurent","year":"2012","unstructured":"Laurent G, Saal S, Amarouch MY, Beziau DM, Marsman RFJ, Faivre L, Barc J, Dina C, Bertaux G, Barthez O, Thauvin-Robinet C, Charron P, Fressart V, Maltret A, Villain E, Baron E, Merot J, Turpault R, Coudiere Y, Charpentier F, Schott J-J, Loussouarn G, Wilde AAM, Wolf J-E, Baro I, Kyndt F (2012) Multifocal ectopic Purkinje-related premature contractions: a new SCN5A-related cardiac channelopathy. J Am Coll Cardiol 60(2):144\u2013156","journal-title":"J Am Coll Cardiol"},{"key":"43_CR56","doi-asserted-by":"crossref","first-page":"27333","DOI":"10.1074\/jbc.M303327200","volume":"278","author":"G Lemaillet","year":"2003","unstructured":"Lemaillet G, Walker B, Lambert S (2003) Identification of a conserved ankyrin-binding motif in the family of sodium channel alpha subunits. J Biol Chem 278:27333\u201327339","journal-title":"J Biol Chem"},{"key":"43_CR57","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbrc.2009.01.052","volume":"380","author":"Q Li","year":"2009","unstructured":"Li Q, Huang H, Liv G, Lam K, Rutberg J, Green MS, Birnie DH, Lemery R, Chahine M, Gollob MH (2009) Gain-of-function mutation of Nav1.5 in atrial fibrillation enhances excitability and lowers the threshold for AP firing. Biochem Biophys Res Commun 380:132\u2013137","journal-title":"Biochem Biophys Res Commun"},{"key":"43_CR58","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1161\/CIRCEP.109.929240","volume":"3","author":"Z Li","year":"2010","unstructured":"Li Z, Ai T, Samani K, Xi Y, Tzeng HP, Xie M, Wu S, Ge S, Taylor MD, Dong JW, Cheng J, Ackerman MJ, Kimura A, Sinagra G, Brunelli L, Faulkner G, Vatta M (2010) A ZASP missense mutation, S196L, leads to cytoskeletal and electrical abnormalities in a mouse model of cardiomyopathy. Circ Arrhythm Electrophysiol 3:646\u2013656","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"43_CR59","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/j.1469-7793.1999.0371p.x","volume":"518","author":"T Lu","year":"1999","unstructured":"Lu T, Lee HC, Kabat JA, Shibata EF (1999) Modulation of rat cardiac sodium channel by the stimulatory G protein alpha subunit. J Physiol 518:371\u2013384","journal-title":"J Physiol"},{"issue":"20","key":"43_CR60","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1001\/jama.2010.1690","volume":"304","author":"SA Lubitz","year":"2010","unstructured":"Lubitz SA, Yin X, Fontes JD, Magnani JW, Rienstra M, Pai M, Villalon ML, Vasan RS, Pencina MJ, Levy D, Marson MG, Ellinor PT, Benjamin EJ (2010) Association between familial atrial fibrillation and risk of new-onset atrial fibrillation. JAMA 304(20):2263\u20132269","journal-title":"JAMA"},{"key":"43_CR61","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1161\/01.CIR.0000121421.61896.24","volume":"109","author":"SK Maier","year":"2004","unstructured":"Maier SK, Westenbroek RE, McCormick KA, Curtis R, Scheuer T, Catterall WA (2004) Distinct subcellular localizationof different sodium channel alpha and beta subunits in single ventricular myocytes from mouse hearts. Circulation 109:1421\u20131427","journal-title":"Circulation"},{"key":"43_CR62","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.hrthm.2005.06.032","volume":"2","author":"N Makita","year":"2005","unstructured":"Makita N, Sasaki K, Groenewegen WA, Yokota T, Yokoshiki H, Murakami T, Tsutsui H (2005) Congenital atrial standstill associated with coinheritance of a novel SCN5A mutation and connexin 40 polymorphisms. Heart Rhythm 2:1128\u20131134","journal-title":"Heart Rhythm"},{"issue":"16","key":"43_CR63","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jacc.2008.07.013","volume":"52","author":"T Makiyama","year":"2008","unstructured":"Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K, Itoh H, Kimura T, Kita T, Horie M (2008a) A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation. J Am Coll Cardiol 52(16):1326\u20131334","journal-title":"J Am Coll Cardiol"},{"key":"43_CR64","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.jacc.2008.07.013","volume":"52","author":"T Makiyama","year":"2008","unstructured":"Makiyama T, Akao M, Shizuta S, Doi T, Nishiyama K, Oka Y, Ohno S, Nishio Y, Tsuji K, Itoh H, Kimura T, Kita T, Horie M (2008b) A novel SCN5A gain-of-function mutation M1875T associated with familial atrial fibrillation. J Am Coll Cardiol 52:1326\u20131334","journal-title":"J Am Coll Cardiol"},{"key":"43_CR131","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1161\/01.CIR.103.9.1303","volume":"103","author":"DJ Malhotra","year":"2001","unstructured":"Malhotra DJ, Chen C, Rivolta I, Abriel H, Malhotra R, Mattei LN, Brosius FC, Kass RS, Isom LL (2001) Characterization of sodium channel alpha and beta subunits in rat and mouse cardiac myocytes. Ciculation 103:1303\u20131310","journal-title":"Ciculation"},{"issue":"16","key":"43_CR65","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1016\/j.jacc.2012.05.050","volume":"60","author":"SA Mann","year":"2012","unstructured":"Mann SA, Castro M, Ohanian M, Ohanian M, Guo G, Zodgekar P, Sheu A, Stockhammer K, Thompson T, Playford D, Subbiah R, Kuchar D, Aggarwal A, Vandenberg JI, Fatkin D (2012) R222Q SCN5A mutation is associated with reversible ventricular ectopy and dilated cardiomyopathy. J Am Coll Cardiol 60(16):1566\u20131573","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"43_CR66","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/nrcardio.2013.186","volume":"11","author":"RF Marsman","year":"2014","unstructured":"Marsman RF, Tan HL, Bezzina CR (2014) Genetics of sudden cardiac death caused by ventricular arrhythmias. Nat Rev Cardiol 11(2):96\u2013111","journal-title":"Nat Rev Cardiol"},{"issue":"7 Pt 1","key":"43_CR67","first-page":"1151","volume":"26","author":"K Matsuo","year":"2003","unstructured":"Matsuo K, Akahoshi M, Seto S, Yano K (2003) Disappearance of the Brugada-type electrocardiogram after surgical castration: a role for testosterone and an explanation for the male preponderance? Pacing Clin Electrophysiol 26(7 Pt 1):1151\u20131153","journal-title":"Pacing Clin Electrophysiol"},{"key":"43_CR68","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/27603","volume":"395","author":"O Mayans","year":"1998","unstructured":"Mayans O, van der Ven PF, Wilm M, Mues A, Young P, Furst DO, Wilmanns M, Gautel M (1998) Structural basis for activation of the titin kinase domain during myofibrillogenesis. Nature 395:863\u2013869","journal-title":"Nature"},{"key":"43_CR69","doi-asserted-by":"crossref","first-page":"16537","DOI":"10.1074\/jbc.M801744200","volume":"283","author":"A Mazzone","year":"2008","unstructured":"Mazzone A, Strege PR, Tester DJ, Bernard CE, Faulkner G, de Giorgio R, Makielski JC, Stanghellini V, Gibbons SJ, Ackerman MJ, Farrugia G (2008) A mutation in telethonin alters Nav1.5 function. J Biol Chem 283:16537\u201316544","journal-title":"J Biol Chem"},{"key":"43_CR132","doi-asserted-by":"crossref","first-page":"52744","DOI":"10.1074\/jbc.M405990200","volume":"279","author":"DP McEwen","year":"2004","unstructured":"McEwen DP, Isom LL (2004) Heterophilic interactions of sodium channel beta 1 subunits with axonal and glial cell adhesion molecules. J Biol Chem 279:52744\u201352752","journal-title":"J Biol Chem"},{"key":"43_CR70","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/01.CIR.0000144458.58660.BB","volume":"110","author":"WP McNair","year":"2004","unstructured":"McNair WP, Ku L, Taylor MR, Fain PR, Dao D, Wolfer E, Mestroni L (2004) SCN5A mutations associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. Circulation 110:2163\u20132167","journal-title":"Circulation"},{"issue":"21","key":"43_CR71","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1016\/j.jacc.2010.09.084","volume":"57","author":"WP McNair","year":"2011","unstructured":"McNair WP, Sinagra G, Taylor MR et al (2011) SCN5A mutations associate with arrhythmic dilated cardiomyopathy and commonly localize to the voltage-sensing mechanism. J Am Coll Cardiol 57(21):2160\u20132168","journal-title":"J Am Coll Cardiol"},{"key":"43_CR133","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.cardiores.2005.04.003","volume":"67","author":"LS Meadows","year":"2005","unstructured":"Meadows LS, Isom LL (2005) Sodium channels as macromolecular complexes: implications for inherited arrhythmia syndromes. Cardiovasc Res 67:448\u2013458","journal-title":"Cardiovasc Res"},{"key":"43_CR134","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1161\/CIRCULATIONAHA.106.659086","volume":"116","author":"A Medeiros-Domingo","year":"2007","unstructured":"Medeiros-Domingo A, Kaku T, Tester DJ, Iturralde-Torres P, Itty A, Ye B, Valdivia C, Ueda K, Canizales-Quinteros S, Tusie-Luna MT, Makielski JC, Ackerman MJ (2007) SCN4B-encoded sodium chanel beta 4 subunit in congenital long-QT syndrome. Circulation 116:134\u2013142","journal-title":"Circulation"},{"key":"43_CR72","doi-asserted-by":"crossref","first-page":"17533","DOI":"10.1073\/pnas.0403711101","volume":"101","author":"PJ Mohler","year":"2004","unstructured":"Mohler PJ, Rivolta I, Napolitano C, LeMaillet G, Lambert S, Priori SG, Bennett V (2004) Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes. Proc Natl Acad Sci U S A 101:17533\u201317538","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"43_CR73","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/j.hrthm.2012.06.029","volume":"9","author":"K Nair","year":"2012","unstructured":"Nair K, Pekhletski R, Harris L et al (2012) Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q. Heart Rhythm 9(10):1681\u20131688","journal-title":"Heart Rhythm"},{"key":"43_CR74","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng.364","volume":"41","author":"C Newton-Cheh","year":"2009","unstructured":"Newton-Cheh C, Eijgelsheim M, Rice KM et al (2009) Common variants at ten loci influence QT interval duration in the QTGEN study. Nat Genet 41:399\u2013406","journal-title":"Nat Genet"},{"issue":"4","key":"43_CR75","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/cvr\/cvq348","volume":"89","author":"MS Olesen","year":"2011","unstructured":"Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH (2011a) Mutations in sodium channel {beta}-subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc Res 89(4):786\u2013793","journal-title":"Cardiovasc Res"},{"key":"43_CR76","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1093\/cvr\/cvq348","volume":"89","author":"MS Olesen","year":"2011","unstructured":"Olesen MS, Jespersen T, Nielsen JB, Liang B, Moller DV, Hedley P, Christiansen M, Varro A, Olesen SP, Haunso S, Schmitt N, Svendsen JH (2011b) Mutations in sodium channel beta subunit SCN3B are associated with early-onset lone atrial fibrillation. Cardiovasc Res 89:786\u2013793","journal-title":"Cardiovasc Res"},{"issue":"4","key":"43_CR77","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1161\/CIRCGENETICS.111.962597","volume":"5","author":"MS Olesen","year":"2012","unstructured":"Olesen MS, Yuan L, Liang B, Holst AG, Nielsen N, Nielsen JB, Hedley PL, Christiansen M, Olesen SP, Haunso S, Schmitt N, Jespersen T, Svendsen JH (2012a) High prevalence of long QT syndrome-associated SCN5A variants in patients with early-onset lone atrial fibrillation. Circ Cardiovasc Genet 5(4):450\u2013459","journal-title":"Circ Cardiovasc Genet"},{"key":"43_CR78","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.hrthm.2011.12.005","volume":"9","author":"MS Olesen","year":"2012","unstructured":"Olesen MS, Holst A, Svendsen JH, Haunso S, Tfelt-Hansen J (2012b) SCN1Bb R214Q found in 3 patients: 1 with Brugada syndrome and 2 with lone atrial fibrillation. Heart Rhythm 9:770\u2013773","journal-title":"Heart Rhythm"},{"issue":"5","key":"43_CR79","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.hrthm.2011.12.005","volume":"9","author":"MS Olesen","year":"2012","unstructured":"Olesen MS, Holst AG, Svendsen JH, Haunso S, Tfelt-Hansen J (2012c) SCN1Bb R214Q found in 3 patients: 1 with Brugada syndrome and 2 with lone atrial fibrillation. Heart Rhythm 9(5):770\u2013773","journal-title":"Heart Rhythm"},{"issue":"4","key":"43_CR80","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/jama.293.4.447","volume":"293","author":"TM Olson","year":"2005","unstructured":"Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, Horton SC, Rodeheffer RJ, Anderson JL (2005a) Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA 293(4):447\u2013454","journal-title":"JAMA"},{"key":"43_CR81","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1001\/jama.293.4.447","volume":"293","author":"TM Olson","year":"2005","unstructured":"Olson TM, Michels V, Ballew JD, Reyna SP, Karst ML, Herron KJ, Horton SC, Rodeheffer RJ, Anderson JL (2005b) Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. JAMA 293:447\u2013454","journal-title":"JAMA"},{"key":"43_CR82","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.neulet.2010.06.050","volume":"486","author":"GA Patino","year":"2010","unstructured":"Patino GA, Isom L (2010) Electrophysiology and beyond: multiple roles of Na+ channel beta subunits in development and disease. Neurosci Lett 486:53\u201359","journal-title":"Neurosci Lett"},{"issue":"7356","key":"43_CR83","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature10238","volume":"475","author":"J Payandeh","year":"2011","unstructured":"Payandeh J, Scheuer T, Zheng N, Catterall WA (2011) The crystal structure of a voltage-gated sodium channel. Nature 475(7356):353\u2013358","journal-title":"Nature"},{"issue":"7401","key":"43_CR84","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/nature11077","volume":"486","author":"J Payandeh","year":"2012","unstructured":"Payandeh J, Gamal El-Din TM, Scheuer T, Zheng N, Catterall WA (2012) Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature 486(7401):135\u2013139","journal-title":"Nature"},{"key":"43_CR135","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/CIRCRESAHA.110.228312","volume":"108","author":"S Petitprez","year":"2011","unstructured":"Petitprez S, Zmoos AF, Ogrodnik J, Balse E, Raad N, El-Haou S, Albesa M, Bittihn P, Luther S, Lehnart SE, Hatem SN, Coulombe A, Abriel H (2011) SAP97 and dystrophin macromolecular complexes determine two pools of cardiac sodium channels Nav1.5 in cardiomyocytes. Circ Res 108:294\u2013304","journal-title":"Circ Res"},{"issue":"4","key":"43_CR85","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng.362","volume":"41","author":"A Pfeufer","year":"2009","unstructured":"Pfeufer A, Sanna S, Arking DE, M\u00fcller M et al (2009) Common variants at ten loci modulate the QT interval duration in the QTSCD study. Nat Genet 41(4):407\u2013414","journal-title":"Nat Genet"},{"issue":"2","key":"43_CR86","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ng.517","volume":"42","author":"A Pfeufer","year":"2010","unstructured":"Pfeufer A, van Noord C, Marciante KD et al (2010) Genome-wide association study of PR interval. Nat Genet 42(2):153\u2013159","journal-title":"Nat Genet"},{"key":"43_CR87","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1161\/CIRCULATIONAHA.105.601294","volume":"114","author":"S Poelzing","year":"2006","unstructured":"Poelzing S, Forleo C, Samodell M, Dudash L, Sorrentino S, Anaclerio M, Troccoli R, Iacoviello M, Romito R, Guida P, Chahine M, Pitzalis M, Deschenes I (2006) SCN5A polymorphism restores trafficking of a Brugada syndrome mutation on a separate gene. Circulation 114:368\u2013376","journal-title":"Circulation"},{"issue":"12","key":"43_CR88","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.hrthm.2013.05.014","volume":"10","author":"SG Priori","year":"2013","unstructured":"Priori SG, Wilde AA, Horie M, Cho Y, Behr ER, Berul C, Blom N, Brugada J, Chiang CE, Huikuri H, Kannankeril P, Krahn A, Leenhardt A, Moss A, Schwartz PJ, Shimizu W, Tomaselli G, Tracy C (2013) HRS\/EHRA\/APHRS expert consensus statement on the diagnosis and management of patients with inherited primary arrhythmia syndromes: document endorsed by HRS, EHRA, and APHRS in May 2013 and by ACCF, AHA, PACES, and AEPC in June 2013. Heart Rhythm 10(12):1932\u20131963","journal-title":"Heart Rhythm"},{"issue":"17","key":"43_CR89","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1113\/jphysiol.2013.256461","volume":"591","author":"C Remme","year":"2013","unstructured":"Remme C (2013) Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects. J Physiol 591(17):4099\u20134116","journal-title":"J Physiol"},{"issue":"20","key":"43_CR90","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.86.20.8170","volume":"86","author":"RB Rogart","year":"1989","unstructured":"Rogart RB, Cribbs LL, Muglia LK, Kephart DD, Kaiser MW (1989) Molecular cloning of a putative tetrodotoxin-resistant rat heart Na+ channel isoform. Proc Natl Acad Sci U S A 86(20):8170\u20138174","journal-title":"Proc Natl Acad Sci U S A"},{"key":"43_CR136","doi-asserted-by":"crossref","first-page":"C692","DOI":"10.1152\/ajpcell.00460.2004","volume":"288","author":"JS Rougier","year":"2005","unstructured":"Rougier JS, van Bemmelen MX, Bruce MC, Jespersen T, Gavilet B, Apotheloz E, Cordonier S, Staub O, Rotin D, Abriel H (2005) Molecular determinants of voltage-gated sodium channel regulation by the Nedd4\/Nedd4-like proteins. Am J Phys Cell Phys 288:C692\u2013C701","journal-title":"Am J Phys Cell Phys"},{"key":"43_CR91","doi-asserted-by":"crossref","first-page":"41447","DOI":"10.1074\/jbc.M006951200","volume":"275","author":"VO Rybin","year":"2000","unstructured":"Rybin VO, Xu X, Lisanti MP, Steinberg SF (2000) Differential targeting of beta adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. J Biol Chem 275:41447\u201341457","journal-title":"J Biol Chem"},{"key":"43_CR92","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCRESAHA.109.201418","volume":"105","author":"PY Sato","year":"2009","unstructured":"Sato PY, Musa H, Coombs W, Guerrero-Serna G, Patinio GA, Taffet SM, Isom LL, Delmar M (2009) Loss of plakophillin-2 expression leads to decreased sodium current and slower conduction velocity in cultured cardiac myocytes. Circ Res 105:523\u2013526","journal-title":"Circ Res"},{"key":"43_CR93","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1161\/CIRCRESAHA.111.247023","volume":"109","author":"PY Sato","year":"2011","unstructured":"Sato PY, Coombs W, Lin X, Nekrasova O, Green KJ, Isom LL, Taffet SM, Delmar M (2011) Interactions between ankyrin-G, plakophilin-2, and connexin43 at the cardiac intercalated disc. Circ Res 109:193\u2013201","journal-title":"Circ Res"},{"key":"43_CR94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2012.00124","volume":"3","author":"E Savio-Galimberti","year":"2012","unstructured":"Savio-Galimberti E, Gollob MH, Darbar D (2012) Voltage-gated sodium channels: biophysics, pharmacology, and related channelopathies. Front Pharmacol 3:1\u201319","journal-title":"Front Pharmacol"},{"issue":"2","key":"43_CR95","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/cvr\/cvu170","volume":"104","author":"E Savio-Galimberti","year":"2014","unstructured":"Savio-Galimberti E, Weeke P, Muhammad R, Blair M, Ansari S, Short L, Atack TC, Kor K, Vanoye CG, Olesen MS, Yang T, George AL Jr, Roden DM, Darbar D (2014) SCN10A\/Nav1.8 modulation of peak and late sodium currents in patients with early onset atrial fibrillation. Cardiovasc Res 104(2):355\u2013363","journal-title":"Cardiovasc Res"},{"issue":"10","key":"43_CR96","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1172\/JCI200316387","volume":"111","author":"E Schulze-Bahr","year":"2003","unstructured":"Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D (2003) Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest 111(10):1537\u20131545","journal-title":"J Clin Invest"},{"key":"43_CR97","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1056\/NEJM200007273430405","volume":"343","author":"PJ Schwartz","year":"2000","unstructured":"Schwartz PJ, Priori SG, Dumaine R, Napolitano C, Antzelevitch C, Stramba-Badiale M, Richard T, Berti MR, Bloise R (2000) A molecular link between the sudden infant death syndrome and the long-QT syndrome. N Engl J Med 343:262\u2013267","journal-title":"N Engl J Med"},{"issue":"4","key":"43_CR98","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/CIRCEP.111.962019","volume":"5","author":"PJ Schwartz","year":"2012","unstructured":"Schwartz PJ, Crotti L, Insolia R (2012) Long QT syndrome: from genetics to management. Circ Arrhythm Electrophysiol 5(4):868\u2013877","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"43_CR99","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/14396","volume":"23","author":"JJ Scott","year":"1999","unstructured":"Scott JJ, Alshinawi C, Kyndt F, Probst V, Hoorntje TM, Hulsbeek M, Wilde AA, Escande D, Mannens MM, Le MH (1999) Cardiac conduction defects associated with mutations in SCN5A. Nat Genet 23:20\u201321","journal-title":"Nat Genet"},{"issue":"6","key":"43_CR100","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1161\/01.CIR.96.6.2038","volume":"96","author":"W Shimizu","year":"1997","unstructured":"Shimizu W, Antzelevitch C (1997) Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation 96(6):2038\u20132047","journal-title":"Circulation"},{"issue":"21","key":"43_CR101","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1161\/01.CIR.98.21.2314","volume":"98","author":"W Shimizu","year":"1998","unstructured":"Shimizu W, Antzelevitch C (1998) Cellular basis for the ECG features of the LQT1 form of the long QT syndrome: effects of beta-adrenergic agonists and antagonists and sodium channel blockers on transmural dispersion of repolarization and torsade de pointes. Circulation 98(21):2314\u20132322","journal-title":"Circulation"},{"key":"43_CR102","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0735-1097(99)00582-3","volume":"35","author":"W Shimizu","year":"2000","unstructured":"Shimizu W, Antzelevitch C (2000) Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 35:778\u2013786","journal-title":"J Am Coll Cardiol"},{"key":"43_CR137","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.bbamcr.2012.10.026","volume":"1833","author":"D Shy","year":"2013","unstructured":"Shy D, Gillet L, Abriel H (2013) Cardiac sodium channel Nav 1.5 distribution in myocytes via interacting proteins: the multiple pool model. Biochim Biophys Acta 1833:886\u2013894","journal-title":"Biochim Biophys Acta"},{"issue":"2","key":"43_CR103","doi-asserted-by":"crossref","first-page":"e1001304","DOI":"10.1371\/journal.pgen.1001304","volume":"7","author":"JG Smith","year":"2011","unstructured":"Smith JG, Magnani J, Palmer C, Meng YA, Soliman EZ, Musani SK et al (2011) Genome-wide association studies of the PR interval in African Americans. PLoS Genet 7(2):e1001304","journal-title":"PLoS Genet"},{"issue":"12","key":"43_CR104","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ng.716","volume":"42","author":"N Sotoodehnia","year":"2010","unstructured":"Sotoodehnia N, Isaacs A, de Bakker PI, Dorr M, Newton-Cheh C, Nolte IM, van der Harst HP, Muller M, Eijgelsheim M, Alonso A, Hicks AA, Padmanabhan S, Hayward C, Smith AV, Polasek O, Giovannone S, Fu J, Magnani JW, Marciante KD, Pfeufer A, Gharib SA, Teumer A, Li M, Bis JC, Rivadeneira F, Aspelund T, Kottgen A, Johnson T, Rice K, Sie MP, Wang YA, Klopp N, Fuchsberger C, Wild SH, Mateo L, Estrada IK, Volker U, Wright AF, Asselbergs FW, Qu J, Chakravarti A, Sinner MF, Kors JA, Petersmann A, Harris TB, Soliman EZ, Munroe PB, Psaty BM, Oostra BA, Cupples LA, Perz S, de Boer RA, Uitterlinden AG, Volzke H, Spector TD, Liu FY, Boerwinkle E, Dominiczak AF, Rotter JI, van Herpen G, Levy D, Wichmann HE, Van Gilst WH, Witteman JC, Kroemer HK, Kao WH, Heckbert SR, Meitinger T, Hofman A, Campbell H, Folsom AR, Van Veldhuisen DJ, Schwienbacher C, O\u2019Donnell CJ, Volpato CB, Caulfield MJ, Connell JM, Launer L, Lu X, Franke L, Fehrmann RS, Te MG, Groen HJ, Weersma RK, van den Berg LH, Wijmenga C, Ophoff RA, Navis G, Rudan I, Snieder H, Wilson JF, Pramstaller PP, Siscovick DS, Wang TJ, Gudnason V, van Duijn CM, Felix SB, Fishman GI, Jamshidi Y, Stricker BHC, Samani NJ, Kaab S, Arking DE (2010a) Common variants in 22 loci are associated with QRS duration and cardiac ventricular conduction. Nat Genet 42(12):1068\u20131076","journal-title":"Nat Genet"},{"key":"43_CR105","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/ng.716","volume":"42","author":"N Sotoodehnia","year":"2010","unstructured":"Sotoodehnia N, Isaacs A, de Bakker PIW et al (2010b) Common variants in 22 loci are associated with QRS duration and cardiac ventricular contraction. Nat Genet 42:1068\u20131076","journal-title":"Nat Genet"},{"issue":"10","key":"43_CR106","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1161\/CIRCRESAHA.116.310112","volume":"120","author":"B Stallmeyer","year":"2017","unstructured":"Stallmeyer B, Kuss J, Kotthoff S, Zumhagen S, Vowinkel K, Rinne S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E (2017) A mutation in the G-protein gene GNB2 causes familial sinus node and Atrioventricular conduction dysfunction. Circ Res 120(10):e33\u2013e44","journal-title":"Circ Res"},{"issue":"e001537","key":"43_CR107","first-page":"1","volume":"10","author":"LA Swayne","year":"2017","unstructured":"Swayne LA, Murphy NP, Asuri S, Chen L, Xu X, McIntosh S, Wang C, Lancione PJ, Roberts JD, Kerr C, Sanatani S, Sherwin E, Kline CF, Zhang M, Mohler PJ, Arbour LT (2017) Novel variant in the ANK2 membrane-binding domain is associated with Ankyrin-B syndrome and structural heart disease in a first nations population with a high rate of long QT syndrome. Circ Cardiovasc Genet 10(e001537):1\u201311","journal-title":"Circ Cardiovasc Genet"},{"key":"43_CR138","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/415442a","volume":"415","author":"HL Tan","year":"2002","unstructured":"Tan HL, Kupershmidt S, Zhang R, Stepanovic S, Roden DM (2002) A calcium sensor in the sodium channel modulates cardiac excitability. Nature 415:442\u2013447","journal-title":"Nature"},{"issue":"1","key":"43_CR108","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13073-017-0410-8","volume":"9","author":"U Tayal","year":"2017","unstructured":"Tayal U, Prasad S, Cook SA (2017) Genetics and genomics of dilated cardiomyopathy and systolic heart failure. Genome Med 9(1):20","journal-title":"Genome Med"},{"issue":"3","key":"43_CR109","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00246-012-0160-8","volume":"33","author":"DJ Tester","year":"2012","unstructured":"Tester DJ, Ackerman MJ (2012) The molecular autopsy: should the evaluation continue after the funeral? Pediatr Cardiol 33(3):461\u2013470","journal-title":"Pediatr Cardiol"},{"key":"43_CR110","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0014-5793(97)01108-3","volume":"415","author":"G Valle","year":"1997","unstructured":"Valle G, Faulkner G, De Antoni A, Pacchioni B, Pallavicini A, Pandolfo D, Tiso N, Toppo S, Trevisan S, Lanfranchi G (1997) Telethonin, a novel sarcomeric protein of heart and skeletal muscle. FEBS Lett 415:163\u2013168","journal-title":"FEBS Lett"},{"key":"43_CR139","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1161\/01.RES.0000136816.05109.89","volume":"95","author":"MX Bemmelen Van","year":"2004","unstructured":"Van Bemmelen MX, Rougier JS, Gavillet B, Apotheloz F, Daidie D, Tateyama M, Rivolta I, Thomas MA, Kass RS, Staub O, Abriel H (2004) Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. Circ Res 95:284\u2013291","journal-title":"Circ Res"},{"key":"43_CR111","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1172\/JCI62613","volume":"122","author":"M Boogaard Van den","year":"2012","unstructured":"Van den Boogaard M, Wong LY, Tessadori F, Bakker ML, Dreizenhnter LK, Wakker V, Bezzina CR, 't Hoen PA, Bakkers J, Barnett P, Christoffels VM (2012) Genetic variations in T-box binding element functionally affects SCN5A\/SCN10A enhancer. J Clin Invest 122:2519\u20132530","journal-title":"J Clin Invest"},{"issue":"20","key":"43_CR112","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1161\/CIRCULATIONAHA.106.635268","volume":"114","author":"M Vatta","year":"2006","unstructured":"Vatta M, Ackerman MJ, Ye B, Makielski JC, Ughanze EE, Taylor EW, Tester DJ, Balijepalli RC, Foell JD, Li Z, Kamp TJ, Towbin JA (2006) Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome. Circulation 114(20):2104\u20132112","journal-title":"Circulation"},{"issue":"3","key":"43_CR113","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1161\/CIRCRESAHA.112.274035","volume":"111","author":"AO Verkerk","year":"2012","unstructured":"Verkerk AO, Remme CA, Schumacher CA, Scicluna BP, Wolswinkel R, de Jonge B, Bezzina CR, Veldkamp MW (2012) Functional Nav1.8 channels in intracardiac neurons: the link between SCN10A and cardiac electrophysiology. Circ Res 111(3):333\u2013343","journal-title":"Circ Res"},{"key":"43_CR114","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1172\/JCI200316879","volume":"111","author":"PC Viswanathan","year":"2003","unstructured":"Viswanathan PC, Benson DW, Balser JR (2003) A common SCN5A polymorphism modulates the biophysical effects of an SCN5A mutation. J Clin Invest 111:341\u2013346","journal-title":"J Clin Invest"},{"key":"43_CR140","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1172\/JCI26620","volume":"116","author":"S Wagner","year":"2006","unstructured":"Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS (2006) Ca\/calmodulin-dependent protein kinase II regulates cardiac Na channels. J Clin Invest 116:3127\u20133128","journal-title":"J Clin Invest"},{"key":"43_CR115","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(95)90359-3","volume":"80","author":"Q Wang","year":"1995","unstructured":"Wang Q, Shen J, Splawski I, Atkinson D, Li Z, Robinson JL, Moss AJ, Towbin JA, Keating MT (1995) SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 80:805\u2013811","journal-title":"Cell"},{"key":"43_CR116","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1006\/geno.1996.0236","volume":"34","author":"Q Wang","year":"1996","unstructured":"Wang Q, Li Z, Shen J, Keating MT (1996) Genomic organization of the human SCN5A gene encoding the cardiac sodium channel. Genomics 34:9\u201316","journal-title":"Genomics"},{"key":"43_CR141","doi-asserted-by":"crossref","first-page":"24253","DOI":"10.1074\/jbc.M111.245803","volume":"286","author":"C Wang","year":"2011","unstructured":"Wang C, Wang C, Hoch EG, Pitt GS (2011) Identification of novel interaction sites that determine specificity between fibroblast growth factor homologous factors and voltage-gated sodium channels. J Biol Chem 286:24253\u201324263","journal-title":"J Biol Chem"},{"issue":"1","key":"43_CR117","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.bbrc.2010.06.042","volume":"398","author":"P Wang","year":"2010","unstructured":"Wang P, Yang Q, Wu X, Yang Y, Shi L, Wang C, Wu G, Xia Y, Yang B, Zhang R, Xu C, Cheng X, Li S, Zhao Y, Fu F, Liao Y, Fang F, Chen Q, Tu X, Wang QK (2010) Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. Biochem Biophys Res Commun 398(1):98\u2013104","journal-title":"Biochem Biophys Res Commun"},{"key":"43_CR118","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1161\/CIRCEP.108.779181","volume":"2","author":"H Watanabe","year":"2009","unstructured":"Watanabe H, Darbar D, Kaiser DW, Jiramongkolchai K, Chopra S, Donahue BS, Kannankeril PJ, Roden DM (2009a) Mutations in sodium channel beta 1 and beta 2 subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2:268\u2013275","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"3","key":"43_CR119","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1161\/CIRCEP.108.779181","volume":"2","author":"H Watanabe","year":"2009","unstructured":"Watanabe H, Darbar D, Kaiser DW, Jirasirirojanakorn K, Chopra S, Donahue BS, Kannankeril P, Roden DM (2009b) Mutations in sodium channel b1 and b2 subunits associated with atrial fibrillation. Circ Arrhythm Electrophysiol 2(3):268\u2013275","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"43_CR120","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.yjmcc.2013.08.004","volume":"64","author":"RE Westernbroek","year":"2013","unstructured":"Westernbroek RE, Bischoff S, Fu Y, Maier SK, Catterall WA, Scheuer T (2013) Localization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry. J Mol Cell Cardiol 64:69\u201378","journal-title":"J Mol Cell Cardiol"},{"issue":"17","key":"43_CR121","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/j.jacc.2014.01.023","volume":"63","author":"DG Wyse","year":"2014","unstructured":"Wyse DG, Van Gelder IC, Ellinor PT, Go AS, Kalman JM, Narayan SM, Nattel S, Schotten U, Rienstra M (2014) Lone atrial fibrillation: does it exist? A \u201cwhite paper\u201d of the journal of the American College of Cardiology. J Am Coll Cardiol 63(17):1715\u20131723","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"43_CR122","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1161\/01.CIR.93.2.372","volume":"93","author":"GX Yan","year":"1996","unstructured":"Yan GX, Antzelevitch C (1996) Cellular basis for the electrocardiographic J wave. Circulation 93(2):372\u2013379","journal-title":"Circulation"},{"issue":"3","key":"43_CR123","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1161\/CIRCRESAHA.112.265173","volume":"111","author":"T Yang","year":"2012","unstructured":"Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM (2012) Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ Res 111(3):322\u2013332","journal-title":"Circ Res"},{"key":"43_CR124","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/hh0402.105177","volume":"90","author":"TL Yarbrough","year":"2002","unstructured":"Yarbrough TL, Lu T, Lee HC, Shibata EF (2002) Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude. Circ Res 90:443\u2013449","journal-title":"Circ Res"},{"key":"43_CR142","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1021\/bi901086v","volume":"49","author":"R Ziane","year":"2010","unstructured":"Ziane R, Huang H, Moghadaszadeh B, Beggs AH, Levesque G, Chahine M (2010) Cell membrane expression of cardiac sodium channel Nav1.5 modulated by alpha-actinin-2 interaction. Biochemistry 49:166\u2013178","journal-title":"Biochemistry"}],"container-title":["Handbook of Experimental Pharmacology","Voltage-gated Sodium Channels: Structure, Function and Channelopathies"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2017_43","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,6,4]],"date-time":"2018-06-04T17:39:49Z","timestamp":1528133989000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/164_2017_43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"ISBN":["9783319902838","9783319902845"],"references-count":142,"URL":"https:\/\/doi.org\/10.1007\/164_2017_43","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}