{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T03:06:02Z","timestamp":1775271962496,"version":"3.50.1"},"publisher-location":"Cham","reference-count":173,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030112707","type":"print"},{"value":"9783030112721","type":"electronic"}],"license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018]]},"DOI":"10.1007\/164_2018_175","type":"book-chapter","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T06:24:59Z","timestamp":1542263099000},"page":"207-241","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Clinical and Experimental Human Sleep-Wake Pharmacogenetics"],"prefix":"10.1007","author":[{"given":"Hans-Peter","family":"Landolt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian C.","family":"Holst","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amandine","family":"Valomon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"175_CR1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.2147\/NSS.S103467","volume":"9","author":"VC Abad","year":"2017","unstructured":"Abad VC, Guilleminault C (2017) New developments in the management of narcolepsy. Nat Sci Sleep 9:39\u201357","journal-title":"Nat Sci Sleep"},{"key":"175_CR2","doi-asserted-by":"publisher","unstructured":"Adamantidis A, Luthi A (2018) Optogenetic dissection of sleep-wake states in vitro and in vivo. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/164_201894","DOI":"10.1007\/164_201894"},{"key":"175_CR3","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1517\/17425255.2013.789018","volume":"9","author":"JAG Agundez","year":"2013","unstructured":"Agundez JAG, Garcia-Martin E, Alonso-Navarro H, Jimenez-Jimenez FJ (2013) Anti-Parkinson\u2019s disease drugs and pharmacogenetic considerations. Expert Opin Drug Metab Toxicol 9:859\u2013874","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"175_CR4","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1124\/dmd.106.012088","volume":"35","author":"T Akutsu","year":"2007","unstructured":"Akutsu T, Kobayashi K, Sakurada K, Ikegaya H, Furihata T, Chiba K (2007) Identification of human cytochrome P450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos 35:72\u201378","journal-title":"Drug Metab Dispos"},{"key":"175_CR5","doi-asserted-by":"crossref","unstructured":"Alston M, Cain SW, Rajaratnam SMW (2018) Advances of melatonin-based therapies in the treatment of disturbed sleep and mood. Handb Exp Pharmacol (in press)","DOI":"10.1007\/164_2018_139"},{"key":"175_CR6","volume-title":"International classification of sleep disorders","author":"American Academy of Sleep Medicine","year":"2014","unstructured":"American Academy of Sleep Medicine (2014) International classification of sleep disorders, 3rd edn. American Academy of Sleep Medicine, Darien","edition":"3"},{"key":"175_CR7","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1007\/s00228-009-0708-6","volume":"65","author":"MEL Arbouw","year":"2009","unstructured":"Arbouw MEL, Movig KLL, Egberts TCG, Poels PJE, van Vugt JPP, Wessels JAM, van der Straaten RJHM, Neef C, Guchelaar HJ (2009) Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson\u2019s disease. Eur J Clin Pharmacol 65:1245\u20131251","journal-title":"Eur J Clin Pharmacol"},{"key":"175_CR8","doi-asserted-by":"publisher","first-page":"e6908","DOI":"10.1371\/journal.pone.0006908","volume":"4","author":"K Azdad","year":"2009","unstructured":"Azdad K, Chavez M, Bischop PD, Wetzelaer P, Marescau B, De Deyn PP, Gall D, Schiffmann SN (2009) Homeostatic plasticity of striatal neurons intrinsic excitability following dopamine depletion. PLoS One 4:e6908","journal-title":"PLoS One"},{"key":"175_CR9","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.smrv.2004.03.002","volume":"8","author":"D Banerjee","year":"2004","unstructured":"Banerjee D, Vitiello MV, Grunstein RR (2004) Pharmacotherapy for excessive daytime sleepiness. Sleep Med Rev 8:339\u2013354","journal-title":"Sleep Med Rev"},{"key":"175_CR10","doi-asserted-by":"publisher","first-page":"14675","DOI":"10.1038\/s41598-017-15063-8","volume":"7","author":"M Batllori","year":"2017","unstructured":"Batllori M, Molero-Luis M, Arrabal L, Heras JD, Fernandez-Ramos JA, Gutierrez-Solana LG, Ibanez-Mico S, Domingo R, Campistol J, Ormazabal A, Sedel F, Opladen T, Zouvelou B, Pons R, Garcia-Cazorla A, Lopez-Laso E, Artuch R (2017) Urinary sulphatoxymelatonin as a biomarker of serotonin status in biogenic amine-deficient patients. Sci Rep 7:14675","journal-title":"Sci Rep"},{"key":"175_CR11","doi-asserted-by":"publisher","unstructured":"Baumann CR (2018) Clinical sleep-wake disorders I: focus on hypersomnias and movement disorders during sleep. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/164_2018126","DOI":"10.1007\/164_2018126"},{"key":"175_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/s10048-010-0254-5","volume":"12","author":"ML Becker","year":"2011","unstructured":"Becker ML, Visser LE, van Schaik RHN, Hofman A, Uitterlinden AG, Stricker BHC (2011) OCT1 polymorphism is associated with response and survival time in anti-Parkinsonian drug users. Neurogenetics 12:79\u201382","journal-title":"Neurogenetics"},{"key":"175_CR13","doi-asserted-by":"publisher","first-page":"71","DOI":"10.5664\/jcsm.2346","volume":"9","author":"J Berner","year":"2013","unstructured":"Berner J (2013) Sodium oxybate intolerance associated with familial serum acylcarnitine elevation. J Clin Sleep Med 9:71\u201372","journal-title":"J Clin Sleep Med"},{"key":"175_CR14","doi-asserted-by":"publisher","first-page":"1224","DOI":"10.1523\/JNEUROSCI.4858-08.2009","volume":"29","author":"A Bertolino","year":"2009","unstructured":"Bertolino A, Fazio L, Di Giorgio A, Blasi G, Romano R, Taurisano P, Caforio G, Sinibaldi L, Ursini G, Popolizio T, Tirotta E, Papp A, Dallapiccola B, Borrelli E, Sadee W (2009) Genetically determined interaction between the dopamine transporter and the D-2 receptor on prefronto-striatal activity and volume in humans. J Neurosci 29:1224\u20131234","journal-title":"J Neurosci"},{"key":"175_CR15","doi-asserted-by":"publisher","first-page":"6485","DOI":"10.1523\/JNEUROSCI.0080-14.2014","volume":"34","author":"SW Black","year":"2014","unstructured":"Black SW, Morairty SR, Chen TM, Leung AK, Wisor JP, Yamanaka A, Kilduff TS (2014) GABA(B) agonism promotes sleep and reduces cataplexy in murine narcolepsy. J Neurosci 34:6485\u20136494","journal-title":"J Neurosci"},{"key":"175_CR16","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1093\/sleep\/33.8.1027","volume":"33","author":"S Bodenmann","year":"2010","unstructured":"Bodenmann S, Landolt HP (2010) Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep 33:1027\u20131035","journal-title":"Sleep"},{"key":"175_CR17","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1038\/clpt.2008.222","volume":"85","author":"S Bodenmann","year":"2009","unstructured":"Bodenmann S, Xu S, Luhmann UFO, Arand M, Berger W, Jung HH, Landolt HP (2009a) Pharmacogenetics of modafinil after sleep loss: catechol-O-methyltransferase genotype modulates waking functions but not recovery sleep. Clin Pharmacol Ther 85:296\u2013304","journal-title":"Clin Pharmacol Ther"},{"key":"175_CR18","doi-asserted-by":"publisher","first-page":"10855","DOI":"10.1523\/JNEUROSCI.1427-09.2009","volume":"29","author":"S Bodenmann","year":"2009","unstructured":"Bodenmann S, Rusterholz T, Durr R, Stoll C, Bachmann V, Geissler E, Jaggi-Schwarz K, Landolt HP (2009b) The functional Val158Met polymorphism of COMT predicts interindividual differences in brain alpha oscillations in young men. J Neurosci 29:10855\u201310862","journal-title":"J Neurosci"},{"key":"175_CR19","doi-asserted-by":"publisher","first-page":"1904","DOI":"10.1111\/j.1476-5381.2011.01689.x","volume":"165","author":"S Bodenmann","year":"2012","unstructured":"Bodenmann S, Hohoff C, Freitag C, Deckert J, R\u00e9tey JV, Bachmann V, Landolt H-P (2012) Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioral performance and sleep EEG after sleep deprivation. Br J Pharmacol 165:1904\u20131913","journal-title":"Br J Pharmacol"},{"key":"175_CR20","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1111\/j.1365-2788.2012.01595.x","volume":"57","author":"W Braam","year":"2013","unstructured":"Braam W, Keijzer H, Boudier HS, Didden R, Smits M, Curfs L (2013) CYP1A2 polymorphisms in slow melatonin metabolisers: a possible relationship with autism spectrum disorder? J Intellect Disabil Res 57:993\u20131000","journal-title":"J Intellect Disabil Res"},{"key":"175_CR21","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/sj.clpt.6100116","volume":"81","author":"J Brockm\u00f6ller","year":"2007","unstructured":"Brockm\u00f6ller J, Meineke I, Kirchheiner J (2007) Pharmacokinetics of mirtazapine: enantioselective effects of the CYP2D6 ultra rapid metabolizer genotype and correlation with adverse effects. Clin Pharmacol Ther 81:699\u2013707","journal-title":"Clin Pharmacol Ther"},{"key":"175_CR22","first-page":"95","volume":"9","author":"M Br\u00fcss","year":"1999","unstructured":"Br\u00fcss M, Bonisch H, Buhlen M, Nothen MM, Propping P, Gothert M (1999) Modified ligand binding to the naturally occurring Cys-124 variant of the human serotonin 5-HT1B receptor. Pharmacogenetics 9:95\u2013102","journal-title":"Pharmacogenetics"},{"key":"175_CR23","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.jsmc.2018.02.006","volume":"13","author":"HJ Burgess","year":"2018","unstructured":"Burgess HJ, Emens JS (2018) Drugs used in circadian sleep-wake rhythm disturbances. Sleep Med Clin 13:231\u2013241","journal-title":"Sleep Med Clin"},{"key":"175_CR24","doi-asserted-by":"publisher","first-page":"305ra146","DOI":"10.1126\/scitranslmed.aac5125","volume":"7","author":"TM Burke","year":"2015","unstructured":"Burke TM, Markwald RR, McHill AW, Chinoy ED, Snider JA, Bessman SC, Jung CM, O\u2019Neill JS, Wright KP (2015) Effects of caffeine on the human circadian clock in vivo and in vitro. Sci Transl Med 7:305ra146","journal-title":"Sci Transl Med"},{"key":"175_CR25","doi-asserted-by":"publisher","first-page":"967","DOI":"10.5665\/sleep.1962","volume":"35","author":"EM Byrne","year":"2012","unstructured":"Byrne EM, Johnson J, McRae AF, Nyholt DR, Medland SE, Gehrman PR, Heath AC, Madden PAF, Montgomery GW, Chenevix-Trench G, Martin NG (2012) A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor. Sleep 35:967\u2013975","journal-title":"Sleep"},{"key":"175_CR26","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/ajmg.b.32168","volume":"162B","author":"EM Byrne","year":"2013","unstructured":"Byrne EM, Gehrman PR, Medland SE, Nyholt DR, Heath AC, Madden PAF, Hickie IB, Van Duijn CM, Henders AK, Montgomery GW, Martin NG, Wray NR, Consortium C (2013) A genome-wide association study of sleep habits and insomnia. Am J Med Genet B Neuropsychiatr Genet 162B:439\u2013451","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"175_CR27","doi-asserted-by":"publisher","first-page":"2764","DOI":"10.1038\/npp.2012.142","volume":"37","author":"K Cai","year":"2012","unstructured":"Cai K, Nanga RPR, Lamprou L, Schinstine C, Elliott M, Hariharan H, Reddy R, Epperson CN (2012) The impact of gabapentin administration on brain GABA and glutamate concentrations: a 7T H-1-MRS study. Neuropsychopharmacology 37:2764\u20132771","journal-title":"Neuropsychopharmacology"},{"key":"175_CR28","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1042\/BST20150276","volume":"44","author":"V Casado-Anguera","year":"2016","unstructured":"Casado-Anguera V, Bonaventura J, Moreno E, Navarro G, Cortes A, Ferre S, Casado V (2016) Evidence for the heterotetrameric structure of the adenosine A(2A)-dopamine D-2 receptor complex. Biochem Soc Trans 44:595\u2013600","journal-title":"Biochem Soc Trans"},{"key":"175_CR29","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1038\/s41582-018-0030-y","volume":"14","author":"A Castelnovo","year":"2018","unstructured":"Castelnovo A, Lopez R, Proserpio P, Nobili L, Dauvilliers Y (2018) NREM sleep parasomnias as disorders of sleep-state dissociation. Nat Rev Neurol 14:470\u2013481","journal-title":"Nat Rev Neurol"},{"key":"175_CR30","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1086\/425589","volume":"75","author":"JS Chen","year":"2004","unstructured":"Chen JS, Lipska BK, Halim N, Ma QD, Matsumoto M, Melhem S, Kolachana BS, Hyde TM, Herman MM, Apud J, Egan MF, Kleinman JE, Weinberger DR (2004) Functional analysis of genetic variation in catechol-o-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. Am J Hum Genet 75:807\u2013821","journal-title":"Am J Hum Genet"},{"key":"175_CR31","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.smrv.2016.01.006","volume":"31","author":"I Clark","year":"2017","unstructured":"Clark I, Landolt HP (2017) Coffee, caffeine, and sleep: a systematic review of epidemiological studies and randomized controlled trials. Sleep Med Rev 31:70\u201378","journal-title":"Sleep Med Rev"},{"key":"175_CR32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.smrv.2004.08.001","volume":"9","author":"B Claustrat","year":"2005","unstructured":"Claustrat B, Brun J, Chazot G (2005) The basic physiology and pathophysiology of melatonin. Sleep Med Rev 9:11\u201324","journal-title":"Sleep Med Rev"},{"key":"175_CR33","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.neuropharm.2004.03.007","volume":"47","author":"DW Cope","year":"2004","unstructured":"Cope DW, Wulff P, Oberto A, Aller MI, Capogna M, Ferraguti F, Halbsguth C, Hoeger H, Jolin HE, Jones A, Mckenzie ANJ, Ogris W, Poeltl A, Sinkkonen ST, Vekovischeva OY, Korpi ER, Sieghart W, Sigel E, Somogyi P, Wisden W (2004) Abolition of zolpidem sensitivity in mice with a point mutation in the GABA(A) receptor gamma 2 subunit. Neuropharmacology 47:17\u201334","journal-title":"Neuropharmacology"},{"key":"175_CR34","doi-asserted-by":"publisher","first-page":"e1002033","DOI":"10.1371\/journal.pgen.1002033","volume":"7","author":"MC Cornelis","year":"2011","unstructured":"Cornelis MC, Monda KL, Yu K, Paynter N, Azzato EM, Bennett SN, Berndt SI, Boerwinkle E, Chanock S, Chatterjee N, Couper D, Curhan G, Heiss G, Hu FB, Hunter DJ, Jacobs K, Jensen MK, Kraft P, Landi MT, Nettleton JA, Purdue MP, Rajaraman P, Rimm EB, Rose LM, Rothman N, Silverman D, Stolzenberg-Solomon R, Subar A, Yeager M, Chasman DI, van Dam RM, Caporaso NE (2011) Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet 7:e1002033","journal-title":"PLoS Genet"},{"key":"175_CR35","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1002\/syn.20927","volume":"65","author":"A Costa","year":"2011","unstructured":"Costa A, Riedel M, Muller U, Moller HJ, Ettinger U (2011) Relationship between SLC6A3 genotype and striatal dopamine transporter availability: a meta-analysis of human single photon emission computed tomography studies. Synapse 65:998\u20131005","journal-title":"Synapse"},{"key":"175_CR36","doi-asserted-by":"publisher","first-page":"882","DOI":"10.3109\/00498254.2015.1129565","volume":"46","author":"DH Cui","year":"2016","unstructured":"Cui DH, Cabalu T, Yee KL, Small J, Li XD, Liu B, Maciolek C, Smith S, Liu W, McCrea JB, Prueksaritanont T (2016) In vitro and in vivo characterisation of the metabolism and disposition of suvorexant in humans. Xenobiotica 46:882\u2013895","journal-title":"Xenobiotica"},{"key":"175_CR37","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1038\/sj.tpj.6500088","volume":"2","author":"Y Dauvilliers","year":"2002","unstructured":"Dauvilliers Y, Neidhart E, Billiard M, Tafti M (2002) Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil. Pharmacogenomics J 2:65\u201368","journal-title":"Pharmacogenomics J"},{"key":"175_CR38","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.3390\/ijms16011111","volume":"16","author":"D De Berardis","year":"2015","unstructured":"De Berardis D, Fornaro M, Serroni N, Campanella D, Rapini G, Olivieri L, Srinivasan V, Iasevoli F, Tomasetti C, De Bartolomeis A, Valchera A, Perna G, Mazza M, Di Nicola M, Martinotti G, Di Giannantonio M (2015) Agomelatine beyond borders: current evidences of its efficacy in disorders other than major depression. Int J Mol Sci 16:1111\u20131130","journal-title":"Int J Mol Sci"},{"key":"175_CR39","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1017\/S109285290001628X","volume":"13","author":"J de Leon","year":"2008","unstructured":"de Leon J, Nikoloff DM (2008) Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. CNS Spectr 13:133\u2013135","journal-title":"CNS Spectr"},{"key":"175_CR40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.5665\/sleep.2316","volume":"36","author":"T Deboer","year":"2013","unstructured":"Deboer T, van Diepen HC, Ferrari MD, Van den Maagdenberg AMJM, Meijer JH (2013) Reduced sleep and low adenosinergic sensitivity in Cacna1a R192Q mutant mice. Sleep 36:127\u2013136","journal-title":"Sleep"},{"key":"175_CR41","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.pharmthera.2013.10.012","volume":"141","author":"M Dresler","year":"2014","unstructured":"Dresler M, Spoormaker VI, Beitinger P, Czisch M, Kimura M, Steiger A, Holsboer F (2014) Neuroscience-driven discovery and development of sleep therapeutics. Pharmacol Ther 141:300\u2013334","journal-title":"Pharmacol Ther"},{"key":"175_CR42","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/nn.4377","volume":"19","author":"A Eban-Rothschild","year":"2016","unstructured":"Eban-Rothschild A, Rothschild G, Giardino WJ, Jones JR, de Lecea L (2016) VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors. Nat Neurosci 19:1356\u20131366","journal-title":"Nat Neurosci"},{"key":"175_CR43","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1038\/npp.2017.294","volume":"43","author":"A Eban-Rothschild","year":"2018","unstructured":"Eban-Rothschild A, Appelbaum L, de Lecea L (2018) Neuronal mechanisms for sleep\/wake regulation and modulatory drive. Neuropsychopharmacology 43:937\u2013952","journal-title":"Neuropsychopharmacology"},{"key":"175_CR44","doi-asserted-by":"publisher","first-page":"6917","DOI":"10.1073\/pnas.111134598","volume":"98","author":"MF Egan","year":"2001","unstructured":"Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR (2001) Effect of COMT Val(108\/158) met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A 98:6917\u20136922","journal-title":"Proc Natl Acad Sci U S A"},{"key":"175_CR45","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.biopha.2006.01.002","volume":"60","author":"C Ekmekcioglu","year":"2006","unstructured":"Ekmekcioglu C (2006) Melatonin receptors in humans: biological role and clinical relevance. Biomed Pharmacother 60:97\u2013108","journal-title":"Biomed Pharmacother"},{"key":"175_CR46","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1126\/science.286.5439.487","volume":"286","author":"WE Evans","year":"1999","unstructured":"Evans WE, Relling MV (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science 286:487\u2013491","journal-title":"Science"},{"key":"175_CR47","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1038\/mp.2013.126","volume":"19","author":"SV Faraone","year":"2014","unstructured":"Faraone SV, Spencer TJ, Madras BK, Zhang-James Y, Biederman J (2014) Functional effects of dopamine transporter gene genotypes on in vivo dopamine transporter functioning: a meta-analysis. Mol Psychiatry 19:880\u2013889","journal-title":"Mol Psychiatry"},{"key":"175_CR48","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1016\/j.biopsych.2011.12.023","volume":"71","author":"SM Farrell","year":"2012","unstructured":"Farrell SM, Tunbridge EM, Braeutigam S, Harrison PJ (2012) COMT Val(158)Met genotype determines the direction of cognitive effects produced by catechol-O-methyltransferase inhibition. Biol Psychiatry 71:538\u2013544","journal-title":"Biol Psychiatry"},{"key":"175_CR49","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/j.1476-5381.2010.00723.x","volume":"160","author":"S Ferre","year":"2010","unstructured":"Ferre S, Lluis C, Justinova Z, Quiroz C, Orru M, Navarro G, Canela EI, Franco R, Goldberg SR (2010) Adenosine-cannabinoid receptor interactions. Implications for striatal function. Br J Pharmacol 160:443\u2013453","journal-title":"Br J Pharmacol"},{"key":"175_CR50","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1046\/j.1365-2869.2000.00191.x","volume":"9","author":"LA Finelli","year":"2000","unstructured":"Finelli LA, Landolt HP, Buck A, Roth C, Berthold T, Borb\u00e9ly AA, Achermann P (2000) Functional neuroanatomy of human sleep states after zolpidem and placebo: a H2 15O-PET study. J Sleep Res 9:161\u2013173","journal-title":"J Sleep Res"},{"key":"175_CR51","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0031-6997(24)01396-6","volume":"51","author":"BB Fredholm","year":"1999","unstructured":"Fredholm BB, B\u00e4ttig K, Holmen J, Nehlig A, Zvartau EE (1999) Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev 51:83\u2013133","journal-title":"Pharmacol Rev"},{"key":"175_CR52","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1016\/j.jaac.2011.08.002","volume":"50","author":"TE Froehlich","year":"2011","unstructured":"Froehlich TE, Epstein JN, Nick TG, Castro MSM, Stein MA, Brinkman WB, Graham AJ, Langberg JM, Kahn RS (2011) Pharmacogenetic predictors of methylphenidate dose-response in attention-deficit\/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 50:1129\u20131139","journal-title":"J Am Acad Child Adolesc Psychiatry"},{"key":"175_CR53","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.sleep.2016.01.017","volume":"21","author":"D Garcia-Borreguero","year":"2016","unstructured":"Garcia-Borreguero D, Silber MH, Winkelman JW, Hogl B, Bainbridge J, Buchfuhrer M, Hadjigeorgiou G, Inoue Y, Manconi M, Oertel W, Ondo W, Winkelmann J, Allen RP (2016) Guidelines for the first-line treatment of restless legs syndrome\/Willis-Ekbom disease, prevention and treatment of dopaminergic augmentation: a combined task force of the IRLSSG, EURLSSG, and the RLS-foundation. Sleep Med 21:1\u201311","journal-title":"Sleep Med"},{"key":"175_CR54","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.sleep.2018.02.002","volume":"45","author":"D Garcia-Borreguero","year":"2018","unstructured":"Garcia-Borreguero D, Guitart X, Garcia Malo C, Cano-Pumarega I, Granizo JJ, Ferre S (2018) Treatment of restless legs syndrome\/Willis-Ekbom disease with the non-selective ENT1\/ENT2 inhibitor dipyridamole: testing the adenosine hypothesis. Sleep Med 45:94\u201397","journal-title":"Sleep Med"},{"key":"175_CR55","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1517\/14656560903005587","volume":"10","author":"HW Goforth","year":"2009","unstructured":"Goforth HW (2009) Low-dose doxepin for the treatment of insomnia: emerging data. Expert Opin Pharmacother 10:1649\u20131655","journal-title":"Expert Opin Pharmacother"},{"key":"175_CR56","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1111\/j.1365-2869.2006.00497.x","volume":"15","author":"JM Gottselig","year":"2006","unstructured":"Gottselig JM, Adam M, R\u00e9tey JV, Khatami R, Achermann P, Landolt HP (2006) Random number generation during sleep deprivation: effects of caffeine on response maintenance and stereotypy. J Sleep Res 15:31\u201340","journal-title":"J Sleep Res"},{"key":"175_CR57","doi-asserted-by":"publisher","first-page":"625","DOI":"10.2217\/14622416.9.5.625","volume":"9","author":"A Gunes","year":"2008","unstructured":"Gunes A, Dahl ML (2008) Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics 9:625\u2013637","journal-title":"Pharmacogenomics"},{"key":"175_CR58","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1742-7843.2006.pto_491.x","volume":"99","author":"S H\u00e4rtter","year":"2006","unstructured":"H\u00e4rtter S, Korhonen T, Lundgren S, Rane A, Tolonen A, Turpeinen M, Laine K (2006) Effect of caffeine intake 12 or 24\u00a0h prior to melatonin intake and CYP1A2*1F polymorphism on CYP1A2 phenotyping by melatonin. Basic Clin Pharmacol Toxicol 99:300\u2013304","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"175_CR59","doi-asserted-by":"publisher","first-page":"501","DOI":"10.3109\/15563650.2015.1049355","volume":"53","author":"V Haufroid","year":"2015","unstructured":"Haufroid V, Hantson P (2015) CYP2D6 genetic polymorphisms and their relevance for poisoning due to amfetamines, opioid analgesics and antidepressants. Clin Toxicol 53:501\u2013510","journal-title":"Clin Toxicol"},{"key":"175_CR60","first-page":"533","volume":"142","author":"O Hayaishi","year":"2004","unstructured":"Hayaishi O, Urade Y, Eguchi N, Huang Z-L (2004) Genes for prostaglandin D synthase and receptor as well as adenosine A2A receptor are involved in the homeostatic regulation of NREM sleep. Arch Ital Biol 142:533\u2013539","journal-title":"Arch Ital Biol"},{"key":"175_CR61","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.jsmc.2018.03.004","volume":"13","author":"J Hedner","year":"2018","unstructured":"Hedner J, Zou D (2018) Drug therapy in obstructive sleep apnea. Sleep Med Clin 13:203","journal-title":"Sleep Med Clin"},{"key":"175_CR62","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1002\/syn.20672","volume":"63","author":"MM Hirvonen","year":"2009","unstructured":"Hirvonen MM, Laakso A, Nagren K, Rinne JO, Pohjalainen T, Hietala J (2009) C957T polymorphism of dopamine D2 receptor gene affects striatal DRD2 in vivo availability by changing the receptor affinity. Synapse 63:907\u2013912","journal-title":"Synapse"},{"key":"175_CR63","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1517\/17425255.2016.1163337","volume":"12","author":"N Hohmann","year":"2016","unstructured":"Hohmann N, Haefeli WE, Mikus G (2016) CYP3A activity: towards dose adaptation to the individual. Expert Opin Drug Metab Toxicol 12:479\u2013497","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"175_CR64","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.neulet.2007.04.009","volume":"420","author":"C Holmes","year":"2007","unstructured":"Holmes C, McCulley M, Nicoll JAR, Alder JT, Chen CPLH, Francis PT (2007) Genetic variation in the 5-HT2A receptor and altered neocortical [H-3] ketanserin binding in Alzheimer\u2019s disease. Neurosci Lett 420:58\u201360","journal-title":"Neurosci Lett"},{"key":"175_CR65","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s40675-014-0007-3","volume":"1","author":"SC Holst","year":"2015","unstructured":"Holst SC, Landolt HP (2015) Sleep homeostasis, metabolism, and adenosine. Curr Sleep Med Rep 1:27\u201337","journal-title":"Curr Sleep Med Rep"},{"key":"175_CR66","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.jsmc.2018.03.002","volume":"13","author":"SC Holst","year":"2018","unstructured":"Holst SC, Landolt HP (2018) Sleep-wake neurochemistry. Sleep Med Clin 13:137\u2013146","journal-title":"Sleep Med Clin"},{"key":"175_CR67","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1523\/JNEUROSCI.4128-13.2014","volume":"34","author":"SC Holst","year":"2014","unstructured":"Holst SC, Bersagliere A, Bachmann V, Berger W, Achermann P, Landolt HP (2014) Dopaminergic role in regulating neurophysiological markers of sleep homeostasis in humans. J Neurosci 34:566\u2013573","journal-title":"J Neurosci"},{"key":"175_CR68","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1146\/annurev-pharmtox-010715-103801","volume":"56","author":"SC Holst","year":"2016","unstructured":"Holst SC, Valomon A, Landolt HP (2016) Sleep pharmacogenetics: personalized sleep-wake therapy. Annu Rev Pharmacol Toxicol 56:577\u2013603","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"175_CR69","doi-asserted-by":"publisher","first-page":"45982","DOI":"10.1038\/srep45982","volume":"7","author":"SC Holst","year":"2017","unstructured":"Holst SC, Muller T, Valomon A, Seebauer B, Berger W, Landolt HP (2017) Functional polymorphisms in dopaminergic genes modulate neurobehavioral and neurophysiological consequences of sleep deprivation. Sci Rep 7:45982","journal-title":"Sci Rep"},{"key":"175_CR70","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.smrv.2004.01.004","volume":"8","author":"WC Houghton","year":"2004","unstructured":"Houghton WC, Scammell TE, Thorpy M (2004) Pharmacotherapy for cataplexy. Sleep Med Rev 8:355\u2013366","journal-title":"Sleep Med Rev"},{"key":"175_CR71","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.npep.2013.10.009","volume":"47","author":"D Hoyer","year":"2013","unstructured":"Hoyer D, Jacobson LH (2013) Orexin in sleep, addiction and more: is the perfect insomnia drug at hand? Neuropeptides 47:477\u2013488","journal-title":"Neuropeptides"},{"key":"175_CR72","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pediatrneurol.2009.02.008","volume":"41","author":"YS Huang","year":"2009","unstructured":"Huang YS, Guilleminault C (2009) Narcolepsy: action of two gamma-aminobutyric acid type B agonists, baclofen and sodium oxybate. Pediatr Neurol 41:9\u201316","journal-title":"Pediatr Neurol"},{"key":"175_CR73","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1038\/nn1491","volume":"8","author":"ZL Huang","year":"2005","unstructured":"Huang ZL, Qu WM, Eguchi N, Chen JF, Schwarzschild MA, Fredholm BB, Urade Y, Hayaishi O (2005) Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci 8:858\u2013859","journal-title":"Nat Neurosci"},{"key":"175_CR74","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.2217\/pgs.13.158","volume":"14","author":"CC Hung","year":"2013","unstructured":"Hung CC, Chen PL, Huang WM, Tai JJ, Hsieh TJ, Ding ST, Hsieh YW, Liou HH (2013) Gene-wide tagging study of the effects of common genetic polymorphisms in the a subunits of the GABA(A) receptor on epilepsy treatment response. Pharmacogenomics 14:1849\u20131856","journal-title":"Pharmacogenomics"},{"key":"175_CR75","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.coph.2014.01.002","volume":"14","author":"C Idzikowski","year":"2014","unstructured":"Idzikowski C (2014) The pharmacology of human sleep, a work in progress? Curr Opin Pharmacol 14:90\u201396","journal-title":"Curr Opin Pharmacol"},{"key":"175_CR76","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.tips.2004.02.007","volume":"25","author":"M Ingelman-Sundberg","year":"2004","unstructured":"Ingelman-Sundberg M (2004) Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future. Trends Pharmacol Sci 25:193\u2013200","journal-title":"Trends Pharmacol Sci"},{"key":"175_CR77","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1176\/ajp.156.9.1447","volume":"156","author":"N Iwata","year":"1999","unstructured":"Iwata N, Cowley DS, Radel M, Roy-Byrne PP, Goldman D (1999) Relationship between a GABA(A)alpha 6 Pro385Ser substitution and benzodiazepine sensitivity. Am J Psychiatry 156:1447\u20131449","journal-title":"Am J Psychiatry"},{"key":"175_CR78","doi-asserted-by":"publisher","first-page":"315","DOI":"10.2190\/PM.37.3.h","volume":"37","author":"RH Kang","year":"2007","unstructured":"Kang RH, Choi MJ, Paik JW, Hahn SW, Lee MS (2007) Effect of serotonin receptor 2A gene polymorphism on mirtazapine response in major depression. Int J Psychiatry Med 37:315\u2013329","journal-title":"Int J Psychiatry Med"},{"key":"175_CR79","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1210\/me.2013-1101","volume":"27","author":"A Karamitri","year":"2013","unstructured":"Karamitri A, Renault N, Clement N, Guillaume JL, Jockers R (2013) Minireview: toward the establishment of a link between melatonin and glucose homeostasis: association of melatonin MT2 receptor variants with type 2 diabetes. Mol Endocrinol 27:1217\u20131233","journal-title":"Mol Endocrinol"},{"key":"175_CR80","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/mp.2008.116","volume":"15","author":"M Kato","year":"2010","unstructured":"Kato M, Serretti A (2010) Review and meta-analysis of antidepressant pharmacogenetic findings in major depressive disorder. Mol Psychiatry 15:473\u2013500","journal-title":"Mol Psychiatry"},{"key":"175_CR81","doi-asserted-by":"publisher","first-page":"243","DOI":"10.2165\/00003088-200039040-00001","volume":"39","author":"CM Kaye","year":"2000","unstructured":"Kaye CM, Nicholls B (2000) Clinical pharmacokinetics of ropinirole. Clin Pharmacokinet 39:243\u2013254","journal-title":"Clin Pharmacokinet"},{"key":"175_CR82","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.canlet.2005.06.051","volume":"234","author":"R Kerb","year":"2006","unstructured":"Kerb R (2006) Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 234:4\u201333","journal-title":"Cancer Lett"},{"key":"175_CR83","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1002\/ajmg.b.30704","volume":"147B","author":"E Kereszturi","year":"2008","unstructured":"Kereszturi E, Tarnok Z, Bognar E, Lakatos K, Farkas L, Gadoros J, Sasvari-Szekely M, Nemoda Z (2008) Catechol-O-methyltransferase Val158Met polymorphism is associated with methylphenidate response in ADHD children. Am J Med Genet B Neuropsychiatr Genet 147B:1431\u20131435","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"175_CR84","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1097\/00008571-200210000-00010","volume":"12","author":"J Kirchheiner","year":"2002","unstructured":"Kirchheiner J, Meineke I, Muller G, Roots L, Brockmoller J (2002) Contributions of CYP2D6, CYP2C9 and CYP2C19 to the biotransformation of E- and Z-doxepin in healthy volunteers. Pharmacogenetics 12:571\u2013580","journal-title":"Pharmacogenetics"},{"key":"175_CR85","doi-asserted-by":"publisher","first-page":"3674","DOI":"10.1073\/pnas.0306975101","volume":"101","author":"C Kopp","year":"2004","unstructured":"Kopp C, Rudolph U, Low K, Tobler I (2004) Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proc Natl Acad Sci U S A 101:3674\u20133679","journal-title":"Proc Natl Acad Sci U S A"},{"key":"175_CR86","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.smrv.2012.08.001","volume":"17","author":"AD Krystal","year":"2013","unstructured":"Krystal AD, Richelson E, Roth T (2013) Review of the histamine system and the clinical effects of H-1 antagonists: basis for a new model for understanding the effects of insomnia medications. Sleep Med Rev 17:263\u2013272","journal-title":"Sleep Med Rev"},{"key":"175_CR87","doi-asserted-by":"publisher","first-page":"1933","DOI":"10.1038\/sj.npp.1300526","volume":"29","author":"HP Landolt","year":"2004","unstructured":"Landolt HP, R\u00e9tey JV, T\u00f6nz K, Gottselig JM, Khatami R, Buckelm\u00fcller I, Achermann P (2004) Caffeine attenuates waking and sleep electroencephalographic markers of sleep homeostasis in humans. Neuropsychopharmacology 29:1933\u20131939","journal-title":"Neuropsychopharmacology"},{"key":"175_CR88","doi-asserted-by":"publisher","first-page":"62","DOI":"10.3389\/fneur.2012.00062","volume":"3","author":"H-P Landolt","year":"2012","unstructured":"Landolt H-P, R\u00e9tey JV, Adam M (2012) Reduced neurobehavioral impairment from sleep deprivation in older adults: contribution of adenosinergic mechanisms. Front Neurol 3:62","journal-title":"Front Neurol"},{"key":"175_CR89","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1517\/13543784.2011.583235","volume":"20","author":"DA Lankford","year":"2011","unstructured":"Lankford DA (2011) Tasimelteon for insomnia. Expert Opin Investig Drugs 20:987\u2013993","journal-title":"Expert Opin Investig Drugs"},{"key":"175_CR90","doi-asserted-by":"publisher","first-page":"10067","DOI":"10.1523\/JNEUROSCI.6730-10.2011","volume":"31","author":"M Lazarus","year":"2011","unstructured":"Lazarus M, Shen HY, Cherasse Y, Qu WM, Huang ZL, Bass CE, Winsky-Sommerer R, Semba K, Fredholm BB, Boison D, Hayaishi O, Urade Y, Chen JF (2011) Arousal effect of caffeine depends on adenosine A(2A) receptors in the shell of the nucleus accumbens. J Neurosci 31:10067\u201310075","journal-title":"J Neurosci"},{"key":"175_CR91","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_36","volume-title":"Handbook of Experimental Pharmacology","author":"Michael Lazarus","year":"2017","unstructured":"Lazarus M, Chen JF, Huang ZL, Urade Y, Fredholm BB (2017) Adenosine and sleep. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/164_2017_36"},{"key":"175_CR92","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1002\/jnr.20602","volume":"81","author":"I Lena","year":"2005","unstructured":"Lena I, Parrot S, Deschaux O, Muffat-Joly S, Sauvinet V, Renaud B, Suaud-Chagny MF, Gottesmann C (2005) Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep-wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats. J Neurosci Res 81:891\u2013899","journal-title":"J Neurosci Res"},{"key":"175_CR93","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1002\/ajmg.b.30024","volume":"129B","author":"T Li","year":"2004","unstructured":"Li T, Chen CK, Hu X, Ball D, Lin SK, Chen W, Sham PC, Loh EW, Murray RM, Collier DA (2004) Association analysis of the DRD4 and COMT genes in methamphetamine abuse. Am J Med Genet B Neuropsychiatr Genet 129B:120\u2013124","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"175_CR94","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1037\/a0018883","volume":"136","author":"J Lim","year":"2010","unstructured":"Lim J, Dinges DF (2010) A meta-analysis of the impact of short-term sleep deprivation on cognitive variables. Psychol Bull 136:375\u2013389","journal-title":"Psychol Bull"},{"key":"175_CR95","doi-asserted-by":"publisher","first-page":"e33767","DOI":"10.1371\/journal.pone.0033767","volume":"7","author":"J Lim","year":"2012","unstructured":"Lim J, Ebstein R, Tse CY, Monakhov M, Lai PS, Dinges DF, Kwok K (2012) Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test. PLoS One 7:e33767","journal-title":"PLoS One"},{"key":"175_CR96","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1124\/jpet.110.170134","volume":"336","author":"JS Lin","year":"2011","unstructured":"Lin JS, Sergeeva OA, Haas HL (2011) Histamine H-3 receptors and sleep-wake regulation. J Pharmacol Exp Ther 336:17\u201323","journal-title":"J Pharmacol Exp Ther"},{"key":"175_CR97","doi-asserted-by":"publisher","first-page":"679","DOI":"10.1007\/s00228-009-0658-z","volume":"65","author":"YZ Liu","year":"2009","unstructured":"Liu YZ, Tang BS, Yan XX, Liu J, Ouyang DS, Nie LN, Fan L, Li Z, Ji W, Hu DL, Wang D, Zhou HH (2009) Association of the DRD2 and DRD3 polymorphisms with response to pramipexole in Parkinson\u2019s disease patients. Eur J Clin Pharmacol 65:679\u2013683","journal-title":"Eur J Clin Pharmacol"},{"key":"175_CR98","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1001\/jamainternmed.2018.2425","volume":"178","author":"E Loftfield","year":"2018","unstructured":"Loftfield E, Cornelis MC, Caporaso N, Yu K, Sinha R, Freedman N (2018) Association of coffee drinking with mortality by genetic variation in caffeine metabolism: findings from the UK Biobank. JAMA Intern Med 178:1086\u20131097","journal-title":"JAMA Intern Med"},{"key":"175_CR99","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1080\/17425255.2017.1246533","volume":"13","author":"M Lozupone","year":"2017","unstructured":"Lozupone M, Panza F, Stella E, La Montagna M, Bisceglia P, Miscio G, Galizia I, Daniele A, di Mauro L, Bellomo A, Logroscino G, Greco A, Seripa D (2017) Pharmacogenetics of neurological and psychiatric diseases at older age: has the time come? Expert Opin Drug Metab Toxicol 13:259\u2013277","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"175_CR100","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1093\/sleep\/30.10.1378","volume":"30","author":"M Luciano","year":"2007","unstructured":"Luciano M, Zhu G, Kirk KM, Gordon SD, Heath AC, Montgomery GW, Martin NG (2007) \u201cNo thanks, it keeps me awake\u201d: the genetics of coffee-attributed sleep disturbance. Sleep 30:1378\u20131386","journal-title":"Sleep"},{"key":"175_CR101","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_84","volume-title":"Handbook of Experimental Pharmacology","author":"Pierre-Herv\u00e9 Luppi","year":"2018","unstructured":"Luppi PH, Fort P (2018) Neuroanatomical and neurochemical bases of vigilance states. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/164_2017_84"},{"key":"175_CR102","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1038\/s41598-017-17022-9","volume":"8","author":"M Maire","year":"2018","unstructured":"Maire M, Reichert CF, Gabel V, Viola AU, Phillips C, Berthomier C, Borgwardt S, Cajochen C, Schmidt C (2018) Human brain patterns underlying vigilant attention: impact of sleep debt, circadian phase and attentional engagement. Sci Rep 8:970","journal-title":"Sci Rep"},{"key":"175_CR103","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.pneurobio.2009.07.004","volume":"89","author":"M Mamelak","year":"2009","unstructured":"Mamelak M (2009) Narcolepsy and depression and the neurobiology of gammahydroxybutyrate. Prog Neurobiol 89:193\u2013219","journal-title":"Prog Neurobiol"},{"key":"175_CR104","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0306-4522(02)00556-0","volume":"116","author":"M Matsumoto","year":"2003","unstructured":"Matsumoto M, Weickert CS, Akil M, Lipska BK, Hyde TM, Herman MM, Kleinman JE, Weinberger DR (2003) Catechol O-methyltransferase mRNA expression in human and rat brain: evidence for a role in cortical neuronal function. Neuroscience 116:127\u2013137","journal-title":"Neuroscience"},{"key":"175_CR105","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1093\/sleep\/34.3.399","volume":"34","author":"DR Mazzotti","year":"2011","unstructured":"Mazzotti DR, Guindalini C, Pellegrino R, Barrueco KF, Santos-Silva R, Bittencourt LRA, Tufik S (2011) Effects of the adenosine deaminase polymorphism and caffeine intake on sleep parameters in a large population sample. Sleep 34:399\u2013402","journal-title":"Sleep"},{"key":"175_CR106","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.sleep.2014.09.011","volume":"16","author":"IR McGrane","year":"2015","unstructured":"McGrane IR, Leung JG, St Louis EK, Boeve BF (2015) Melatonin therapy for REM sleep behavior disorder: a critical review of evidence. Sleep Med 16:19\u201326","journal-title":"Sleep Med"},{"key":"175_CR107","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1007\/s13311-012-0150-9","volume":"9","author":"EJM Mignot","year":"2012","unstructured":"Mignot EJM (2012) A practical guide to the therapy of narcolepsy and hypersomnia syndromes. Neurotherapeutics 9:739\u2013752","journal-title":"Neurotherapeutics"},{"key":"175_CR108","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/S0013-4694(98)00044-3","volume":"107","author":"MM Mitler","year":"1998","unstructured":"Mitler MM, Walsleben J, Sangal RB, Hirshkowitz M (1998) Sleep latency on the maintenance of wakefulness test (MWT) for 530 patients with narcolepsy while free of psychoactive drugs. Electroencephalogr Clin Neurophysiol 107:33\u201338","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"175_CR109","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1097\/WNF.0000000000000119","volume":"39","author":"M Moresco","year":"2016","unstructured":"Moresco M, Riccardi LN, Pizza F, Zenesini C, Caporali L, Plazzi G, Pelotti S (2016) Pharmacogenetics and treatment response in narcolepsy type 1: relevance of the polymorphisms of the drug transporter gene ABCB1. Clin Neuropharmacol 39:18\u201323","journal-title":"Clin Neuropharmacol"},{"key":"175_CR110","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/0013-4694(49)90219-9","volume":"1","author":"G Moruzzi","year":"1949","unstructured":"Moruzzi G, Magoun HW (1949) Brain stem and EEG activation. Electroencephalogr Clin Neurophysiol 1:455\u2013473","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"175_CR111","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.forsciint.2012.08.050","volume":"227","author":"MA Neukamm","year":"2013","unstructured":"Neukamm MA, Vogt S, Hermanns-Clausen M, Naue J, Thierauf A, Auwarter V (2013) Fatal doxepin intoxication \u2013 suicide or slow gradual intoxication? Forensic Sci Int 227:82\u201384","journal-title":"Forensic Sci Int"},{"key":"175_CR112","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1038\/nm.4433","volume":"23","author":"Y Nir","year":"2017","unstructured":"Nir Y, Andrillon T, Marmelshtein A, Suthana N, Cirelli C, Tononi G, Fried I (2017) Selective neuronal lapses precede human cognitive lapses following sleep deprivation. Nat Med 23:1474\u20131480","journal-title":"Nat Med"},{"key":"175_CR113","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.sleep.2012.07.008","volume":"14","author":"N Nittur","year":"2013","unstructured":"Nittur N, Konofal E, Dauvilliers Y, Franco P, Leu-Semenescu S, De Cock VC, Inocente CO, Bayard S, Scholtz S, Lecendreux M, Arnulf I (2013) Mazindol in narcolepsy and idiopathic and symptomatic hypersomnia refractory to stimulants: a long-term chart review. Sleep Med 14:30\u201336","journal-title":"Sleep Med"},{"key":"175_CR114","doi-asserted-by":"publisher","first-page":"2907","DOI":"10.1007\/s00429-017-1365-7","volume":"222","author":"Y Oishi","year":"2017","unstructured":"Oishi Y, Suzuki Y, Takahashi K, Yonezawa T, Kanda T, Takata Y, Cherasse Y, Lazarus M (2017a) Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D-2-like receptors in mice. Brain Struct Funct 222:2907\u20132915","journal-title":"Brain Struct Funct"},{"key":"175_CR115","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/s41467-017-00781-4","volume":"8","author":"Y Oishi","year":"2017","unstructured":"Oishi Y, Xu Q, Wang L, Zhang BJ, Takahashi K, Takata Y, Luo YJ, Cherasse Y, Schiffmann SN, d\u2019Exaerde AD, Urade Y, Qu WM, Huang ZL, Lazarus M (2017b) Slow-wave sleep is controlled by a subset of nucleus accumbens core neurons in mice. Nat Commun 8:734","journal-title":"Nat Commun"},{"key":"175_CR116","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1016\/j.clpt.2006.02.008","volume":"79","author":"JY Park","year":"2006","unstructured":"Park JY, Kim KA, Park PL, Lee OJ, Kang DK, Shon JH, Liu KH, Shin JG (2006) Effect of CYP3A5*3 genotype on the pharmacokinetics and pharmacodynamics of alprazolam in healthy subjects. Clin Pharmacol Ther 79:590\u2013599","journal-title":"Clin Pharmacol Ther"},{"key":"175_CR117","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1007\/s12031-011-9522-6","volume":"45","author":"HJ Park","year":"2011","unstructured":"Park HJ, Park JK, Kim SK, Cho AR, Kim JW, Yim SV, Chung JH (2011) Association of polymorphism in the promoter of the melatonin receptor 1A gene with schizophrenia and with insomnia symptoms in schizophrenia patients. J Mol Neurosci 45:304\u2013308","journal-title":"J Mol Neurosci"},{"key":"175_CR118","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1002\/ajmg.b.32106","volume":"162B","author":"MJ Parsons","year":"2013","unstructured":"Parsons MJ, Lester KJ, Barclay NL, Nolan PM, Eley TC, Gregory AM (2013) Replication of genome-wide association studies (GWAS) loci for sleep in the British G1219 cohort. Am J Med Genet B Neuropsychiatr Genet 162B:431\u2013438","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"175_CR119","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1177\/1060028015570467","volume":"49","author":"KV Patel","year":"2015","unstructured":"Patel KV, Aspesi AV, Evoy KE (2015) Suvorexant: a dual orexin receptor antagonist for the treatment of sleep onset and sleep maintenance insomnia. Ann Pharmacother 49:477\u2013483","journal-title":"Ann Pharmacother"},{"key":"175_CR120","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1038\/npp.2011.45","volume":"36","author":"JK Pinsonneault","year":"2011","unstructured":"Pinsonneault JK, Han DD, Burdick KE, Kataki M, Bertolino A, Malhotra AK, Gu HH, Sadee W (2011) Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder. Neuropsychopharmacology 36:1644\u20131655","journal-title":"Neuropsychopharmacology"},{"key":"175_CR121","doi-asserted-by":"publisher","first-page":"914168","DOI":"10.5402\/2012\/914168","volume":"2012","author":"A Proctor","year":"2012","unstructured":"Proctor A, Bianchi MT (2012) Clinical pharmacology in sleep medicine. ISRN Pharmacol 2012:914168","journal-title":"ISRN Pharmacol"},{"key":"175_CR122","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1093\/cercor\/bhu241","volume":"26","author":"MH Qiu","year":"2016","unstructured":"Qiu MH, Yao QL, Vetrivelan R, Chen MC, Lu J (2016) Nigrostriatal dopamine acting on globus pallidus regulates sleep. Cereb Cortex 26:1430\u20131439","journal-title":"Cereb Cortex"},{"key":"175_CR123","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00213-010-2149-4","volume":"215","author":"JG Ramaekers","year":"2011","unstructured":"Ramaekers JG, Conen S, de Kam PJ, Braat S, Peeters P, Theunissen EL, Ivgy-may N (2011) Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype. Psychopharmacology 215:321\u2013332","journal-title":"Psychopharmacology"},{"key":"175_CR124","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00008571-200208000-00008","volume":"12","author":"BB Rasmussen","year":"2002","unstructured":"Rasmussen BB, Brix TH, Kyvik KO, Brosen K (2002) The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors. Pharmacogenetics 12:473\u2013478","journal-title":"Pharmacogenetics"},{"key":"175_CR125","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1016\/j.euroneuro.2015.03.001","volume":"25","author":"G Renda","year":"2015","unstructured":"Renda G, Committeri G, Zimarino M, Di Nicola M, Tatasciore A, Ruggieri B, Ambrosini E, Viola V, Antonucci I, Stuppia L, De Caterina R (2015) Genetic determinants of cognitive responses to caffeine drinking identified from a double-blind, randomized, controlled trial. Eur Neuropsychopharmacol 25:798\u2013807","journal-title":"Eur Neuropsychopharmacol"},{"key":"175_CR126","doi-asserted-by":"publisher","first-page":"10472","DOI":"10.1523\/JNEUROSCI.1538-06.2006","volume":"26","author":"JV R\u00e9tey","year":"2006","unstructured":"R\u00e9tey JV, Adam M, Gottselig JM, Khatami R, D\u00fcrr R, Achermann P, Landolt H-P (2006) Adenosinergic mechanisms contribute to individual differences in sleep-deprivation induced changes in neurobehavioral function and brain rhythmic activity. J Neurosci 26:10472\u201310479","journal-title":"J Neurosci"},{"key":"175_CR127","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1038\/sj.clpt.6100102","volume":"81","author":"JV R\u00e9tey","year":"2007","unstructured":"R\u00e9tey JV, Adam M, Khatami R, Luhmann UFO, Jung HH, Berger W, Landolt H-P (2007) A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81:692\u2013698","journal-title":"Clin Pharmacol Ther"},{"key":"175_CR128","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1756-6606-6-8","volume":"6","author":"A Rhodin","year":"2013","unstructured":"Rhodin A, Gronbladh A, Ginya H, Nilsson KW, Rosenblad A, Zhou Q, Enlund M, Hallberg M, Gordh T, Nyberg F (2013) Combined analysis of circulating beta-endorphin with gene polymorphisms in OPRM1, CACNAD2 and ABCB1 reveals correlation with pain, opioid sensitivity and opioid-related side effects. Mol Brain 6:8","journal-title":"Mol Brain"},{"key":"175_CR129","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.smrv.2008.06.001","volume":"13","author":"D Riemann","year":"2009","unstructured":"Riemann D, Perlis ML (2009) The treatments of chronic insomnia: a review of benzodiazepine receptor agonists and psychological and behavioral therapies. Sleep Med Rev 13:205\u2013214","journal-title":"Sleep Med Rev"},{"key":"175_CR130","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1517\/13543776.2014.1001739","volume":"25","author":"S Rivara","year":"2015","unstructured":"Rivara S, Pala D, Bedini A, Spadoni G (2015) Therapeutic uses of melatonin and melatonin derivatives: a patent review (2012\u20132014). Expert Opin Ther Pat 25:425\u2013441","journal-title":"Expert Opin Ther Pat"},{"key":"175_CR131","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.109.914820","volume":"123","author":"DM Roden","year":"2011","unstructured":"Roden DM, Wilke RA, Kroemer HK, Stein CM (2011) Pharmacogenomics the genetics of variable drug responses. Circulation 123:1661\u20131670","journal-title":"Circulation"},{"key":"175_CR132","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1365-2869.2012.01062.x","volume":"22","author":"TL Rupp","year":"2013","unstructured":"Rupp TL, Wesensten NJ, Newman R, Balkin TJ (2013) PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction. J Sleep Res 22:160\u2013165","journal-title":"J Sleep Res"},{"key":"175_CR133","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1046\/j.1365-2125.1999.00898.x","volume":"47","author":"C Sachse","year":"1999","unstructured":"Sachse C, Brochmoller J, Bauer S, Roots I (1999) Functional significance of a C\u00a0\u2192\u00a0A polymorphism in intron I of the cytochrome P450 CYP1A2 gene tested with caffeine. Br J Clin Pharmacol 47:445\u2013449","journal-title":"Br J Clin Pharmacol"},{"key":"175_CR134","doi-asserted-by":"publisher","first-page":"R207","DOI":"10.1093\/hmg\/ddi261","volume":"14","author":"W Sadee","year":"2005","unstructured":"Sadee W, Dai Z (2005) Pharmacogenetics\/genomics and personalized medicine. Hum Mol Genet 14:R207\u2013R214","journal-title":"Hum Mol Genet"},{"key":"175_CR135","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.conb.2017.03.021","volume":"44","author":"CB Saper","year":"2017","unstructured":"Saper CB, Fuller PM (2017) Wake-sleep circuitry: an overview. Curr Opin Neurobiol 44:186\u2013192","journal-title":"Curr Opin Neurobiol"},{"key":"175_CR136","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1007\/s00228-006-0210-3","volume":"62","author":"J Saruwatari","year":"2006","unstructured":"Saruwatari J, Matsunaga M, Ikeda K, Nakao M, Oniki K, Seo T, Mihara S, Marubayashi T, Kamataki T, Nakagawa K (2006) Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia. Eur J Clin Pharmacol 62:995\u20131001","journal-title":"Eur J Clin Pharmacol"},{"key":"175_CR137","doi-asserted-by":"publisher","first-page":"zsx167","DOI":"10.1093\/sleep\/zsx167","volume":"40","author":"BC Satterfield","year":"2017","unstructured":"Satterfield BC, Wisor JP, Schmidt MA, Van Dongen HPA (2017) Time-on-task effect during sleep deprivation in healthy young adults is modulated by dopamine transporter genotype. Sleep 40:zsx167","journal-title":"Sleep"},{"key":"175_CR138","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.cortex.2017.11.012","volume":"99","author":"BC Satterfield","year":"2018","unstructured":"Satterfield BC, Hinson JM, Whitney P, Schmidt MA, Wisor JP, Van Dongen HPA (2018) Catechol-O-methyltransferase (COMT) genotype affects cognitive control during total sleep deprivation. Cortex 99:179\u2013186","journal-title":"Cortex"},{"key":"175_CR139","doi-asserted-by":"publisher","first-page":"72","DOI":"10.3109\/07420528.2013.823200","volume":"31","author":"IW Saxvig","year":"2014","unstructured":"Saxvig IW, Wilhelmsen-Langeland A, Pallesen S, Vedaa O, Nordhus IH, Bjorvatn B (2014) A randomized controlled trial with bright light and melatonin for delayed sleep phase disorder: effects on subjective and objective sleep. Chronobiol Int 31:72\u201386","journal-title":"Chronobiol Int"},{"key":"175_CR140","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1053\/j.semnuclmed.2012.06.003","volume":"42","author":"J Seibyl","year":"2012","unstructured":"Seibyl J, Russell D, Jennings D, Marek K (2012) Neuroimaging over the course of Parkinson\u2019s disease: from early detection of the at-risk patient to improving pharmacotherapy of later-stage disease. Semin Nucl Med 42:406\u2013414","journal-title":"Semin Nucl Med"},{"key":"175_CR141","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.forsciint.2012.08.035","volume":"227","author":"M Shen","year":"2013","unstructured":"Shen M, Shi Y, Xiang P (2013) CYP3A4 and CYP2C19 genetic polymorphisms and zolpidem metabolism in the Chinese Han population: a pilot study. Forensic Sci Int 227:77\u201381","journal-title":"Forensic Sci Int"},{"key":"175_CR142","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1007\/s00204-013-1173-7","volume":"88","author":"N Siller","year":"2014","unstructured":"Siller N, Egerer G, Weiss J, Mikus G (2014) Prolonged sedation of lorazepam due to absent UGT2B4\/2B7 glucuronidation. Arch Toxicol 88:179\u2013180","journal-title":"Arch Toxicol"},{"key":"175_CR143","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/jcpt.12118","volume":"39","author":"L Song","year":"2014","unstructured":"Song L, Du Q, Jiang X, Wang L (2014) Effect of CYP1A2 polymorphism on the pharmacokinetics of agomelatine in Chinese healthy male volunteers. J Clin Pharm Ther 39:204\u2013209","journal-title":"J Clin Pharm Ther"},{"key":"175_CR144","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_40","volume-title":"Handbook of Experimental Pharmacology","author":"Kai Spiegelhalder","year":"2017","unstructured":"Spiegelhalder K, Nissen C, Riemann D (2017) Clinical sleep-wake disorders II: focus on insomnia and circadian rhythm sleep disorders. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/164_2017_40"},{"key":"175_CR145","doi-asserted-by":"publisher","first-page":"988","DOI":"10.2174\/156802608784936728","volume":"8","author":"EM Stocking","year":"2008","unstructured":"Stocking EM, Letavic MA (2008) Histamine H(3) antagonists as wake-promoting and pro-cognitive agents. Curr Top Med Chem 8:988\u20131002","journal-title":"Curr Top Med Chem"},{"key":"175_CR146","doi-asserted-by":"publisher","first-page":"2071","DOI":"10.1093\/hmg\/ddr086","volume":"20","author":"P Sulem","year":"2011","unstructured":"Sulem P, Gudbjartsson DF, Geller F, Prokopenko I, Feenstra B, Aben KKH, Franke B, den Heijer M, Kovacs P, Stumvoll M, Magi R, Yanek LR, Becker LC, Boyd HA, Stacey SN, Walters GB, Jonasdottir A, Thorleifsson G, Holm H, Gudjonsson SA, Rafnar T, Bjornsdottir G, Becker DM, Melbye M, Kong A, Tonjes A, Thorgeirsson T, Thorsteinsdottir U, Kiemeney LA, Stefansson K (2011) Sequence variants at CYP1A1-CYP1A2 and AHR associate with coffee consumption. Hum Mol Genet 20:2071\u20132077","journal-title":"Hum Mol Genet"},{"key":"175_CR147","first-page":"57","volume":"8","author":"MD Thompson","year":"2014","unstructured":"Thompson MD, Xhaard H, Sakurai T, Rainero I, Kukkonen JP (2014) OX1 and OX2 orexin\/hypocretin receptor pharmacogenetics. Front Neurosci 8:57","journal-title":"Front Neurosci"},{"key":"175_CR148","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.sleep.2014.10.002","volume":"16","author":"MJ Thorpy","year":"2015","unstructured":"Thorpy MJ, Dauvilliers Y (2015) Clinical and practical considerations in the pharmacologic management of narcolepsy. Sleep Med 16:9\u201318","journal-title":"Sleep Med"},{"key":"175_CR149","doi-asserted-by":"publisher","first-page":"6464","DOI":"10.1073\/pnas.111055398","volume":"98","author":"I Tobler","year":"2001","unstructured":"Tobler I, Kopp C, Deboer T, Rudolph U (2001) Diazepam-induced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proc Natl Acad Sci U S A 98:6464\u20136469","journal-title":"Proc Natl Acad Sci U S A"},{"key":"175_CR150","doi-asserted-by":"publisher","first-page":"e828","DOI":"10.1038\/tp.2016.93","volume":"6","author":"D Tomasi","year":"2016","unstructured":"Tomasi D, Wang GJ, Volkow ND (2016) Association between striatal dopamine D-2\/D-3 receptors and brain activation during visual attention: effects of sleep deprivation. Transl Psychiatry 6:e828","journal-title":"Transl Psychiatry"},{"key":"175_CR151","doi-asserted-by":"crossref","unstructured":"Toth K, Csukly G, Sirok D, Belic A, Kiss A, Hafra E, Deri M, Menus A, Bitter I, Monostory K (2016) Optimization of clonazepam therapy adjusted to patient\u2019s CYP3A status and NAT2 genotype. Int J Neuropsychopharmacol 19","DOI":"10.1093\/ijnp\/pyw083"},{"key":"175_CR152","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrneurol.2010.55","volume":"6","author":"C Trenkwalder","year":"2010","unstructured":"Trenkwalder C, Paulus W (2010) Restless legs syndrome: pathophysiology, clinical presentation and management. Nat Rev Neurol 6:337\u2013346","journal-title":"Nat Rev Neurol"},{"key":"175_CR153","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1016\/S1474-4422(13)70239-4","volume":"12","author":"C Trenkwalder","year":"2013","unstructured":"Trenkwalder C, Benes H, Grote L, Garcia-Borreguero D, Hogl B, Hopp M, Bosse B, Oksche A, Reimer K, Winkelmann J, Allen RP, Kohnen R, Grp RS (2013) Prolonged release oxycodone-naloxone for treatment of severe restless legs syndrome after failure of previous treatment: a double-blind, randomised, placebo-controlled trial with an open-label extension. Lancet Neurol 12:1141\u20131150","journal-title":"Lancet Neurol"},{"issue":"5","key":"175_CR154","doi-asserted-by":"publisher","first-page":"e12695","DOI":"10.1111\/jsr.12695","volume":"27","author":"JL Treur","year":"2018","unstructured":"Treur JL, Gibson M, Taylor AE, Rogers PJ, Munaf\u00f2 MR (2018) Investigating genetic correlations and causal effects between caffeine consumption and sleep behaviours. J Sleep Res 27(5):e12695","journal-title":"J Sleep Res"},{"key":"175_CR155","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.biopsych.2005.10.024","volume":"60","author":"EM Tunbridge","year":"2006","unstructured":"Tunbridge EM, Harrison PJ, Weinberger DR (2006) Catechol-o-methyltransferase, cognition, and psychosis: Val(158)Met and beyond. Biol Psychiatry 60:141\u2013151","journal-title":"Biol Psychiatry"},{"key":"175_CR156","doi-asserted-by":"publisher","first-page":"1773","DOI":"10.3390\/ijms18081773","volume":"18","author":"SM Tyree","year":"2017","unstructured":"Tyree SM, de Lecea L (2017) Optogenetic investigation of arousal circuits. Int J Mol Sci 18:1773","journal-title":"Int J Mol Sci"},{"key":"175_CR157","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1038\/sj.tpj.6500189","volume":"3","author":"H Ujike","year":"2003","unstructured":"Ujike H, Harano M, Inada T, Yamada M, Komiyama T, Sekine Y, Sora I, Iyo M, Katsu T, Nomura A, Nakata K, Ozaki N (2003) Nine- or fewer repeat alleles in VNTR polymorphism of the dopamine transporter gene is a strong risk factor for prolonged methamphetamine psychosis. Pharmacogenomics J 3:242\u2013247","journal-title":"Pharmacogenomics J"},{"key":"175_CR158","doi-asserted-by":"publisher","first-page":"773","DOI":"10.1097\/FPC.0b013e3281c6d08e.","volume":"17","author":"TJ Urban","year":"2007","unstructured":"Urban TJ, Yang C, Castro RA, Taylor TR, Huang CC, Stryke D, Johns SJ, Kawamoto M, Carlson EJ, Ferrin TE, Burchard EG, Giacomini KM (2007) Functional effects of protein sequence polymorphisms in the organic cation\/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics 17:773\u2013782","journal-title":"Pharmacogenet Genomics"},{"key":"175_CR159","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s12986-016-0126-6","volume":"13","author":"E Urry","year":"2016","unstructured":"Urry E, Jetter A, Landolt HP (2016) Assessment of CYP1A2 enzyme activity in relation to type-2 diabetes and habitual caffeine intake. Nutr Metab 13:66","journal-title":"Nutr Metab"},{"key":"175_CR160","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1177\/0269881116668595","volume":"31","author":"E Urry","year":"2017","unstructured":"Urry E, Jetter A, Holst SC, Berger W, Spinas GA, Langhans W, Landolt HP (2017) A case-control field study on the relationships among type 2 diabetes, sleepiness and habitual caffeine intake. J Psychopharmacol 31:233\u2013242","journal-title":"J Psychopharmacol"},{"key":"175_CR161","doi-asserted-by":"publisher","first-page":"1599","DOI":"10.1038\/s41386-018-0018-8","volume":"43","author":"A Valomon","year":"2018","unstructured":"Valomon A, Holst SC, Borrello A, Weigend S, Muller T, Berger W, Sommerauer M, Baumann CR, Landolt HP (2018) Effects of COMT genotype and tolcapone on lapses of sustained attention after sleep deprivation in healthy young men. Neuropsychopharmacology 43:1599\u20131607","journal-title":"Neuropsychopharmacology"},{"key":"175_CR162","first-page":"423","volume":"27","author":"HPA Van Dongen","year":"2004","unstructured":"Van Dongen HPA, Baynard MD, Maislin G, Dinges DF (2004) Systematic interindividual differences in neurobehavioral impairment from sleep loss: evidence of trait-like differential vulnerability. Sleep 27:423\u2013433","journal-title":"Sleep"},{"key":"175_CR163","doi-asserted-by":"crossref","unstructured":"Varin C, Bonnavion P (2018) Pharmacosynthetic deconstruction of sleep-wake circuits in the brain. Handb Exp Pharmacol (in press)","DOI":"10.1007\/164_2018_183"},{"key":"175_CR164","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1001\/jama.2009.351","volume":"301","author":"ND Volkow","year":"2009","unstructured":"Volkow ND, Fowler JS, Logan J, Alexoff D, Zhu W, Telang F, Wang GJ, Jayne M, Hooker JM, Wong C, Hubbard B, Carter P, Warner D, King P, Shea C, Xu YW, Muench L, Apelskog-Torres K (2009) Effects of modafinil on dopamine and dopamine transporters in the male human brain clinical implications. JAMA 301:1148\u20131154","journal-title":"JAMA"},{"key":"175_CR165","doi-asserted-by":"publisher","first-page":"6711","DOI":"10.1523\/JNEUROSCI.0045-12.2012","volume":"32","author":"ND Volkow","year":"2012","unstructured":"Volkow ND, Tomasi D, Wang GJ, Telang F, Fowler JS, Logan J, Benveniste H, Kim R, Thanos PK, Ferre S (2012) Evidence that sleep deprivation downregulates dopamine D2R in ventral striatum in the human brain. J Neurosci 32:6711\u20136717","journal-title":"J Neurosci"},{"key":"175_CR166","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bbr.2013.12.045","volume":"262","author":"SL Weinhold","year":"2014","unstructured":"Weinhold SL, Seeck-Hirschner M, Nowak A, Hallschmid M, Goder R, Baier PC (2014) The effect of intranasal orexin-A (hypocretin-1) on sleep, wakefulness and attention in narcolepsy with cataplexy. Behav Brain Res 262:8\u201313","journal-title":"Behav Brain Res"},{"key":"175_CR167","doi-asserted-by":"publisher","first-page":"16020","DOI":"10.1038\/s41598-017-16165-z","volume":"7","author":"P Whitney","year":"2017","unstructured":"Whitney P, Hinson JM, Satterfield BC, Grant DA, Honn KA, Van Dongen HPA (2017) Sleep deprivation diminishes attentional control effectiveness and impairs flexible adaptation to changing conditions. Sci Rep 7:16020","journal-title":"Sci Rep"},{"key":"175_CR168","doi-asserted-by":"publisher","first-page":"103","DOI":"10.7326\/M15-1781","volume":"165","author":"TJ Wilt","year":"2016","unstructured":"Wilt TJ, MacDonald R, Brasure M, Olson CM, Carlyle M, Fuchs E, Khawaja IS, Diem S, Koffel E, Ouellette J, Butler M, Kane RL (2016) Pharmacologic treatment of insomnia disorder: an evidence report for a clinical practice guideline by the American College of Physicians. Ann Int Med 165:103\u2013112","journal-title":"Ann Int Med"},{"issue":"7","key":"175_CR169","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1002\/mds.27260","volume":"33","author":"J Winkelmann","year":"2018","unstructured":"Winkelmann J, Allen RP, Hogl B, Inoue Y, Oertel W, Salminen AV, Winkelman JW, Trenkwalder C, Sampaio C (2018) Treatment of restless legs syndrome: evidence-based review and implications for clinical practice (Revised 2017). Mov Disord 33(7):1077\u20131091","journal-title":"Mov Disord"},{"key":"175_CR170","doi-asserted-by":"publisher","unstructured":"Wisor JP (2018) Dopamine and wakefulness: pharmacology, genetics and circuitry. Handb Exp Pharmacol. https:\/\/doi.org\/10.1007\/164_201895","DOI":"10.1007\/164_201895"},{"key":"175_CR171","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1523\/JNEUROSCI.21-05-01787.2001","volume":"21","author":"JP Wisor","year":"2001","unstructured":"Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM (2001) Dopaminergic role in stimulant-induced wakefulness. J Neurosci 21:1787\u20131794","journal-title":"J Neurosci"},{"key":"175_CR172","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1016\/j.neuroscience.2015.06.033","volume":"301","author":"LM Yager","year":"2015","unstructured":"Yager LM, Garcia AF, Wunsch AM, Ferguson SM (2015) The ins and outs of the striatum: role in drug addiction. Neuroscience 301:529\u2013541","journal-title":"Neuroscience"},{"key":"175_CR173","doi-asserted-by":"publisher","first-page":"43","DOI":"10.3389\/fnana.2013.00043","volume":"7","author":"JP Zhang","year":"2013","unstructured":"Zhang JP, Xu Q, Yuan XS, Cherasse Y, Schiffmann SN, d\u2019Exaerde AD, Qu WM, Urade Y, Lazarus M, Huang ZL, Li RX (2013) Projections of nucleus accumbens adenosine A(2A) receptor neurons in the mouse brain and their implications in mediating sleep-wake regulation. Front Neuroanat 7:43","journal-title":"Front Neuroanat"}],"container-title":["Handbook of Experimental Pharmacology","Sleep-Wake Neurobiology and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2018_175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T02:22:24Z","timestamp":1775269344000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2018_175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"ISBN":["9783030112707","9783030112721"],"references-count":173,"URL":"https:\/\/doi.org\/10.1007\/164_2018_175","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]},"assertion":[{"value":"16 November 2018","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}