{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:38:25Z","timestamp":1791315505193,"version":"4.3.1"},"publisher-location":"Cham","reference-count":233,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030685096","type":"print"},{"value":"9783030685102","type":"electronic"}],"license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020]]},"DOI":"10.1007\/164_2020_382","type":"book-chapter","created":{"date-parts":[[2020,8,14]],"date-time":"2020-08-14T05:03:05Z","timestamp":1597381385000},"page":"169-204","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Nitric Oxide Synthase Inhibitors into the Clinic at Last"],"prefix":"10.1007","author":[{"given":"Vu Thao-Vi","family":"Dao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud H.","family":"Elbatreek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Fuch\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Gr\u00e4dler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald H. H. W.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay M.","family":"Shah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Knowles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,15]]},"reference":[{"issue":"5","key":"382_CR1","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1073\/pnas.0304264101","volume":"101","author":"A Ahluwalia","year":"2004","unstructured":"Ahluwalia A et al (2004) Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A 101(5):1386\u20131391","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"382_CR2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1042\/bj3570593","volume":"357","author":"WK Alderton","year":"2001","unstructured":"Alderton WK, Cooper CE, Knowles RG (2001) Nitric oxide synthases: structure, function and inhibition. Biochem J 357(3):593\u2013615","journal-title":"Biochem J"},{"issue":"3","key":"382_CR3","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/sj.bjp.0706168","volume":"145","author":"WK Alderton","year":"2005","unstructured":"Alderton WK et al (2005) GW274150 and GW273629 are potent and highly selective inhibitors of inducible nitric oxide synthase in vitro and in vivo. Br J Pharmacol 145(3):301\u2013312","journal-title":"Br J Pharmacol"},{"issue":"5","key":"382_CR4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0049-3848(87)90361-6","volume":"47","author":"U Alheid","year":"1987","unstructured":"Alheid U, Fr\u00f6lich JC, F\u00f6rstermann U (1987) Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res 47(5):561\u2013571","journal-title":"Thromb Res"},{"key":"382_CR5","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.3389\/fimmu.2018.02379","volume":"9","author":"GP Amarante-Mendes","year":"2018","unstructured":"Amarante-Mendes GP et al (2018) Pattern recognition receptors and the host cell death molecular machinery. Front Immunol 9:2379","journal-title":"Front Immunol"},{"issue":"1","key":"382_CR6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s43044-020-00062-4","volume":"72","author":"W Ammar","year":"2020","unstructured":"Ammar W et al (2020) Assessment of vascular stiffness using different modalities in patients with systemic lupus erythematosus: a case control study. Egypt Heart J (EHJ) 72(1):24","journal-title":"Egypt Heart J (EHJ)"},{"key":"382_CR7","doi-asserted-by":"publisher","unstructured":"Annedi SC et al (2011) Discovery ofN-(3-(1-Methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain. J Med Chem:7408\u20137416. https:\/\/doi.org\/10.1021\/jm201063u","DOI":"10.1021\/jm201063u"},{"issue":"7","key":"382_CR8","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1016\/j.bmcl.2012.02.004","volume":"22","author":"SC Annedi","year":"2012","unstructured":"Annedi SC et al (2012) Novel, druglike 1,7-disubstituted 2,3,4,5-tetrahydro-1H-benzo[b]azepine-based selective inhibitors of human neuronal nitric oxide synthase (nNOS). Bioorg Med Chem Lett 22(7):2510\u20132513","journal-title":"Bioorg Med Chem Lett"},{"issue":"9","key":"382_CR9","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1093\/eurheartj\/ehp061","volume":"30","author":"C Antoniades","year":"2009","unstructured":"Antoniades C et al (2009) Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. Eur Heart J 30(9):1142\u20131150","journal-title":"Eur Heart J"},{"key":"382_CR10","doi-asserted-by":"publisher","unstructured":"Aquilano K, Baldelli S, Ciriolo MR (2014) Nuclear recruitment of neuronal nitric-oxide synthase by \u03b1-syntrophin is crucial for the induction of mitochondrial biogenesis. J Biol Chem:365\u2013378. https:\/\/doi.org\/10.1074\/jbc.m113.506733","DOI":"10.1074\/jbc.m113.506733"},{"issue":"4","key":"382_CR11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/0026-0495(73)90069-3","volume":"22","author":"MD Armstrong","year":"1973","unstructured":"Armstrong MD, Stave U (1973) A study of plasma free amino acid levels. II. Normal values for children and adults. Metab Clin Exp 22(4):561\u2013569","journal-title":"Metab Clin Exp"},{"key":"382_CR12","doi-asserted-by":"publisher","unstructured":"Averna M et al (2008) Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells. J Biol Chem:29069\u201329076. https:\/\/doi.org\/10.1074\/jbc.m803638200","DOI":"10.1074\/jbc.m803638200"},{"issue":"3","key":"382_CR13","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1172\/JCI118181","volume":"96","author":"MA Awolesi","year":"1995","unstructured":"Awolesi MA, Sessa WC, Sumpio BE (1995) Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J Clin Invest 96(3):1449\u20131454","journal-title":"J Clin Invest"},{"key":"382_CR14","doi-asserted-by":"crossref","first-page":"12157","DOI":"10.1038\/srep12157","volume":"5","author":"A Bach","year":"2015","unstructured":"Bach A et al (2015) Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ\/PSD-95-PDZ interactions. Sci Rep 5:12157","journal-title":"Sci Rep"},{"key":"382_CR15","doi-asserted-by":"publisher","unstructured":"Baig MS et al (2015) NOS1-derived nitric oxide promotes NF-\u03baB transcriptional activity through inhibition of suppressor of cytokine signaling-1. J Exp Med:1725\u20131738. https:\/\/doi.org\/10.1084\/jem.20140654","DOI":"10.1084\/jem.20140654"},{"issue":"5","key":"382_CR16","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2165\/00129784-200707050-00003","volume":"7","author":"A Bailey","year":"2007","unstructured":"Bailey A et al (2007) The tragedy of TRIUMPH for nitric oxide synthesis inhibition in cardiogenic shock: where do we go from here? Am J Cardiovasc Drugs 7(5):337\u2013345","journal-title":"Am J Cardiovasc Drugs"},{"issue":"8","key":"382_CR17","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1517\/13543784.2014.918953","volume":"23","author":"P Barbanti","year":"2014","unstructured":"Barbanti P et al (2014) Drugs targeting nitric oxide synthase for migraine treatment. Expert Opin Investig Drugs 23(8):1141\u20131148","journal-title":"Expert Opin Investig Drugs"},{"key":"382_CR18","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.redox.2017.09.009","volume":"14","author":"S Bartesaghi","year":"2018","unstructured":"Bartesaghi S, Radi R (2018) Fundamentals on the biochemistry of peroxynitrite and protein tyrosine nitration. Redox Biol 14:618\u2013625","journal-title":"Redox Biol"},{"key":"382_CR20","doi-asserted-by":"publisher","unstructured":"Baydoun AR et al (2006) Y LAT-1 mediates transport of the potent and selective iNOS inhibitor, GW274150, in control J774 macrophages. Amino Acids:101\u2013109. https:\/\/doi.org\/10.1007\/s00726-005-0311-9","DOI":"10.1007\/s00726-005-0311-9"},{"key":"382_CR21","doi-asserted-by":"publisher","unstructured":"Beaton H et al (2001a) 3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency. Bioorg Med Chem Lett:1023\u20131026. https:\/\/doi.org\/10.1016\/s0960-894x(01)00119-6","DOI":"10.1016\/s0960-894x(01)00119-6"},{"issue":"8","key":"382_CR22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0960-894X(01)00120-2","volume":"11","author":"H Beaton","year":"2001","unstructured":"Beaton H et al (2001b) Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity. Bioorg Med Chem Lett 11(8):1027\u20131030","journal-title":"Bioorg Med Chem Lett"},{"key":"382_CR23","doi-asserted-by":"publisher","unstructured":"Bender AT et al (1999) Neuronal nitric-oxide synthase is regulated by the hsp90-based chaperone systemin vivo. J Biol Chem:1472\u20131478. https:\/\/doi.org\/10.1074\/jbc.274.3.1472","DOI":"10.1074\/jbc.274.3.1472"},{"issue":"52","key":"382_CR24","doi-asserted-by":"crossref","first-page":"33293","DOI":"10.1074\/jbc.271.52.33293","volume":"271","author":"V Berka","year":"1996","unstructured":"Berka V, Chen PF, Tsai AL (1996) Spatial relationship between L-arginine and heme binding sites of endothelial nitric-oxide synthase. J Biol Chem 271(52):33293\u201333300","journal-title":"J Biol Chem"},{"key":"382_CR25","doi-asserted-by":"publisher","unstructured":"Bhatt DK et al (2013) NXN-188, a selective nNOS inhibitor and a 5-HT1B\/1D receptor agonist, inhibits CGRP release in preclinical migraine models. Cephalalgia:87\u2013100. https:\/\/doi.org\/10.1177\/0333102412466967","DOI":"10.1177\/0333102412466967"},{"issue":"1","key":"382_CR26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s40272-019-00373-3","volume":"22","author":"T Biselele","year":"2020","unstructured":"Biselele T et al (2020) A phase iia clinical trial of 2-Iminobiotin for the treatment of Birth Asphyxia in DR Congo, a low-income country. Paediatr Drugs 22(1):95\u2013104","journal-title":"Paediatr Drugs"},{"key":"382_CR27","doi-asserted-by":"publisher","unstructured":"Blasko E et al (2002) Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors. J Biol Chem:295\u2013302. https:\/\/doi.org\/10.1074\/jbc.m105691200","DOI":"10.1074\/jbc.m105691200"},{"issue":"3","key":"382_CR28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.it.2015.01.003","volume":"36","author":"C Bogdan","year":"2015","unstructured":"Bogdan C (2015) Nitric oxide synthase in innate and adaptive immunity: an update. Trends Immunol 36(3):161\u2013178","journal-title":"Trends Immunol"},{"issue":"19","key":"382_CR29","doi-asserted-by":"crossref","first-page":"9191","DOI":"10.1073\/pnas.90.19.9191","volume":"90","author":"GA B\u00f6hme","year":"1993","unstructured":"B\u00f6hme GA et al (1993) Altered synaptic plasticity and memory formation in nitric oxide synthase inhibitor-treated rats. Proc Natl Acad Sci U S A 90(19):9191\u20139194","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"50","key":"382_CR30","doi-asserted-by":"crossref","first-page":"33142","DOI":"10.1074\/jbc.273.50.33142","volume":"273","author":"HM B\u00f6mmel","year":"1998","unstructured":"B\u00f6mmel HM et al (1998) Anti-pterins as tools to characterize the function of tetrahydrobiopterin in NO synthase. J Biol Chem 273(50):33142\u201333149","journal-title":"J Biol Chem"},{"issue":"2","key":"382_CR31","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1073\/pnas.87.2.682","volume":"87","author":"DS Bredt","year":"1990","unstructured":"Bredt DS, Snyder SH (1990) Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci U S A 87(2):682\u2013685","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6329","key":"382_CR32","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/351714a0","volume":"351","author":"DS Bredt","year":"1991","unstructured":"Bredt DS et al (1991) Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature 351(6329):714\u2013718","journal-title":"Nature"},{"key":"382_CR33","doi-asserted-by":"publisher","unstructured":"Brenman JE et al (1996) Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and \u03b11-syntrophin mediated by PDZ domains. Cell:757\u2013767. https:\/\/doi.org\/10.1016\/s0092-8674(00)81053-3","DOI":"10.1016\/s0092-8674(00)81053-3"},{"key":"382_CR34","doi-asserted-by":"publisher","unstructured":"Bruder N (2012) Faculty opinions recommendation of safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Faculty Opin Post Publ Peer Rev Biomed Lit. https:\/\/doi.org\/10.3410\/f.717961804.793464512","DOI":"10.3410\/f.717961804.793464512"},{"issue":"4","key":"382_CR35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.euroneuro.2016.01.008","volume":"26","author":"E Candemir","year":"2016","unstructured":"Candemir E et al (2016) Interaction of NOS1AP with the NOS-I PDZ domain: implications for schizophrenia-related alterations in dendritic morphology. Eur Neuropsychopharmacol 26(4):741\u2013755","journal-title":"Eur Neuropsychopharmacol"},{"issue":"14","key":"382_CR36","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1089\/ars.2015.6433","volume":"23","author":"AI Casas","year":"2015","unstructured":"Casas AI et al (2015) Reactive oxygen-related diseases: therapeutic targets and emerging clinical indications. Antioxid Redox Signal 23(14):1171\u20131185","journal-title":"Antioxid Redox Signal"},{"issue":"46","key":"382_CR37","doi-asserted-by":"crossref","first-page":"12315","DOI":"10.1073\/pnas.1705034114","volume":"114","author":"AI Casas","year":"2017","unstructured":"Casas AI et al (2017) NOX4-dependent neuronal autotoxicity and BBB breakdown explain the superior sensitivity of the brain to ischemic damage. Proc Natl Acad Sci U S A 114(46):12315\u201312320","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"382_CR38","doi-asserted-by":"crossref","first-page":"7129","DOI":"10.1073\/pnas.1820799116","volume":"116","author":"AI Casas","year":"2019","unstructured":"Casas AI et al (2019) From single drug targets to synergistic network pharmacology in ischemic stroke. Proc Natl Acad Sci U S A 116(14):7129\u20137136","journal-title":"Proc Natl Acad Sci U S A"},{"key":"382_CR39","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3389\/fncel.2017.00180","volume":"11","author":"A Caviedes","year":"2017","unstructured":"Caviedes A et al (2017) Endothelial nitric oxide synthase is present in dendritic spines of neurons in primary cultures. Front Cell Neurosci 11:180","journal-title":"Front Cell Neurosci"},{"issue":"19","key":"382_CR40","doi-asserted-by":"crossref","first-page":"10824","DOI":"10.1073\/pnas.96.19.10824","volume":"96","author":"PE Chabrier","year":"1999","unstructured":"Chabrier PE et al (1999) BN 80933, a dual inhibitor of neuronal nitric oxide synthase and lipid peroxidation: a promising neuroprotective strategy. Proc Natl Acad Sci U S A 96(19):10824\u201310829","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"382_CR41","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1189\/jlb.1011513","volume":"91","author":"S Chakrabarti","year":"2012","unstructured":"Chakrabarti S et al (2012) Neuronal nitric oxide synthase regulates endothelial inflammation. J Leukoc Biol 91(6):947\u2013956","journal-title":"J Leukoc Biol"},{"key":"382_CR42","doi-asserted-by":"publisher","unstructured":"Chan Y et al (2004) The cell-specific expression of endothelial nitric-oxide synthase. J Biol Chem:35087\u201335100. https:\/\/doi.org\/10.1074\/jbc.m405063200","DOI":"10.1074\/jbc.m405063200"},{"key":"382_CR43","doi-asserted-by":"publisher","unstructured":"Chen C-A et al (2010) S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature:1115\u20131118. https:\/\/doi.org\/10.1038\/nature09599","DOI":"10.1038\/nature09599"},{"issue":"7","key":"382_CR44","first-page":"795","volume":"4","author":"DR Cheshire","year":"2001","unstructured":"Cheshire DR (2001) Use of nitric oxide synthase inhibitors for the treatment of inflammatory disease and pain. IDrugs Invest Drugs J 4(7):795\u2013803","journal-title":"IDrugs Invest Drugs J"},{"issue":"8","key":"382_CR45","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1016\/j.bmcl.2011.02.061","volume":"21","author":"DR Cheshire","year":"2011","unstructured":"Cheshire DR et al (2011) The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS). Bioorg Med Chem Lett 21(8):2468\u20132471","journal-title":"Bioorg Med Chem Lett"},{"key":"382_CR46","doi-asserted-by":"publisher","unstructured":"Chida N et al (2005) Pharmacological profile of FR260330, a novel orally active inducible nitric oxide synthase inhibitor. Eur J Pharmacol:71\u201376. https:\/\/doi.org\/10.1016\/j.ejphar.2004.12.028","DOI":"10.1016\/j.ejphar.2004.12.028"},{"issue":"2","key":"382_CR47","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1084\/jem.176.2.599","volume":"176","author":"HJ Cho","year":"1992","unstructured":"Cho HJ et al (1992) Calmodulin is a subunit of nitric oxide synthase from macrophages. J Exp Med 176(2):599\u2013604","journal-title":"J Exp Med"},{"issue":"3","key":"382_CR48","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1007\/s12035-017-0513-7","volume":"55","author":"C-M Chong","year":"2018","unstructured":"Chong C-M et al (2018) Roles of nitric oxide synthase isoforms in neurogenesis. Mol Neurobiol 55(3):2645\u20132652","journal-title":"Mol Neurobiol"},{"key":"382_CR49","doi-asserted-by":"publisher","unstructured":"Chreifi G et al (2014) Communication between the zinc and tetrahydrobiopterin binding sites in nitric oxide synthase. Biochemistry:4216\u20134223. https:\/\/doi.org\/10.1021\/bi5003986","DOI":"10.1021\/bi5003986"},{"key":"382_CR50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1874104500903010008","volume":"3","author":"G-H Chu","year":"2009","unstructured":"Chu G-H et al (2009) Design and synthesis of imidazopyrimidine derivatives as potent iNOS dimerization inhibitors. Open Med Chem J 3:8\u201313","journal-title":"Open Med Chem J"},{"issue":"1","key":"382_CR51","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/med.21599","volume":"40","author":"MA Cinelli","year":"2020","unstructured":"Cinelli MA et al (2020) Inducible nitric oxide synthase: regulation, structure, and inhibition. Med Res Rev 40(1):158\u2013189","journal-title":"Med Res Rev"},{"issue":"12","key":"382_CR52","doi-asserted-by":"crossref","first-page":"3320","DOI":"10.1021\/jm031035n","volume":"47","author":"S Connolly","year":"2004","unstructured":"Connolly S et al (2004) 2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution. J Med Chem 47(12):3320\u20133323","journal-title":"J Med Chem"},{"key":"382_CR53","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fncel.2014.00252","volume":"8","author":"MJ Courtney","year":"2014","unstructured":"Courtney MJ, Li L-L, Lai YY (2014) Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling. Front Cell Neurosci 8:252","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"382_CR54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.niox.2011.04.004","volume":"25","author":"MJ Crabtree","year":"2011","unstructured":"Crabtree MJ, Channon KM (2011) Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease. Nitric Oxide Biol Chem 25(2):81\u201388","journal-title":"Nitric Oxide Biol Chem"},{"issue":"37","key":"382_CR55","doi-asserted-by":"crossref","first-page":"9901","DOI":"10.1523\/JNEUROSCI.1464-07.2007","volume":"27","author":"H Cui","year":"2007","unstructured":"Cui H et al (2007) PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors. J Neurosci Off J Soc Neurosci 27(37):9901\u20139915","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"382_CR56","doi-asserted-by":"publisher","unstructured":"Cuzzocrea S et al (2002) Beneficial effects of GW274150, a novel, potent and selective inhibitor of iNOS activity, in a rodent model of collagen-induced arthritis. Eur J Pharmacol:119\u2013129. https:\/\/doi.org\/10.1016\/s0014-2999(02)02338-5","DOI":"10.1016\/s0014-2999(02)02338-5"},{"issue":"11","key":"382_CR57","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1111\/j.1582-4934.2010.01227.x","volume":"15","author":"VT-V Dao","year":"2011","unstructured":"Dao VT-V et al (2011) Catalase activity prevents exercise-induced up-regulation of vasoprotective proteins in venous tissue. J Cell Mol Med 15(11):2326\u20132334","journal-title":"J Cell Mol Med"},{"issue":"14","key":"382_CR58","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1089\/ars.2015.6430","volume":"23","author":"VT-V Dao","year":"2015","unstructured":"Dao VT-V et al (2015) Pharmacology and clinical drug candidates in redox medicine. Antioxid Redox Signal 23(14):1113\u20131129","journal-title":"Antioxid Redox Signal"},{"key":"382_CR59","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bcp.2016.05.011","volume":"112","author":"VT-V Dao","year":"2016","unstructured":"Dao VT-V et al (2016) Nitric oxide up-regulates endothelial expression of angiotensin II type 2 receptors. Biochem Pharmacol 112:24\u201336","journal-title":"Biochem Pharmacol"},{"key":"382_CR60","doi-asserted-by":"publisher","unstructured":"Dao VT-V et al (2020) Non-canonical chemical feedback self-limits nitric oxide-cyclic GMP signaling in health and disease. Sci Rep. https:\/\/doi.org\/10.1038\/s41598-020-66639-w","DOI":"10.1038\/s41598-020-66639-w"},{"key":"#cr-split#-382_CR61.1","doi-asserted-by":"crossref","unstructured":"Davila-Gonzalez D. et al. (2018) Abstract A202: evaluating the combination of anti-PD-1 and nitric oxide synthase inhibition therapy in 12 triple-negative breast cancer patient-derived xenografts using a human-derived immune system model. In: Immune checkpoints. abstracts: AACR-NCI-EORTC international conference: molecular targets and cancer therapeutics","DOI":"10.1158\/1535-7163.TARG-17-A202"},{"key":"#cr-split#-382_CR61.2","unstructured":"October 26-30, 2017. American Association for Cancer Research, Philadelphia, pp A202-A202."},{"key":"382_CR62","doi-asserted-by":"publisher","unstructured":"Dell\u2019Albani P et al (2001) JAK\/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures. J Neurosci Res:417\u2013424. https:\/\/doi.org\/10.1002\/jnr.1169","DOI":"10.1002\/jnr.1169"},{"key":"382_CR63","doi-asserted-by":"publisher","unstructured":"Dimmeler S et al (1999) Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature:601\u2013605. https:\/\/doi.org\/10.1038\/21224","DOI":"10.1038\/21224"},{"key":"382_CR64","doi-asserted-by":"publisher","unstructured":"Drummond GR et al (2000) Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression by hydrogen peroxide. Circ Res:347\u2013354. https:\/\/doi.org\/10.1161\/01.res.86.3.347","DOI":"10.1161\/01.res.86.3.347"},{"key":"382_CR65","doi-asserted-by":"publisher","unstructured":"Dudzinski DM et al (2006) The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol:235\u2013276. https:\/\/doi.org\/10.1146\/annurev.pharmtox.44.101802.121844","DOI":"10.1146\/annurev.pharmtox.44.101802.121844"},{"issue":"7","key":"382_CR66","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1164\/rccm.200209-1031PP","volume":"167","author":"P Enkhbaatar","year":"2003","unstructured":"Enkhbaatar P et al (2003) The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury. Am J Respir Crit Care Med 167(7):1021\u20131026","journal-title":"Am J Respir Crit Care Med"},{"issue":"20","key":"382_CR67","doi-asserted-by":"crossref","first-page":"19888","DOI":"10.1074\/jbc.M413058200","volume":"280","author":"PA Erwin","year":"2005","unstructured":"Erwin PA et al (2005) Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 280(20):19888\u201319894","journal-title":"J Biol Chem"},{"issue":"6","key":"382_CR68","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.pupt.2012.08.004","volume":"25","author":"RL Evans","year":"2012","unstructured":"Evans RL et al (2012) A comparison of antiasthma drugs between acute and chronic ovalbumin-challenged Guinea-pig models of asthma. Pulm Pharmacol Ther 25(6):453\u2013464","journal-title":"Pulm Pharmacol Ther"},{"key":"382_CR69","doi-asserted-by":"publisher","unstructured":"Eynott PR et al (2002) Role of nitric oxide in allergic inflammation and bronchial hyperresponsiveness. Eur J Pharmacol:123\u2013133. https:\/\/doi.org\/10.1016\/s0014-2999(02)02237-9","DOI":"10.1016\/s0014-2999(02)02237-9"},{"issue":"10","key":"382_CR70","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/nrmicro1004","volume":"2","author":"FC Fang","year":"2004","unstructured":"Fang FC (2004) Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2(10):820\u2013832","journal-title":"Nat Rev Microbiol"},{"key":"382_CR71","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jpba.2015.11.045","volume":"120","author":"M Fantacuzzi","year":"2016","unstructured":"Fantacuzzi M et al (2016) Screening of NOS activity and selectivity of newly synthesized acetamidines using RP-HPLC. J Pharm Biomed Anal 120:419\u2013424","journal-title":"J Pharm Biomed Anal"},{"issue":"4","key":"382_CR72","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/s41390-019-0587-1","volume":"87","author":"LMA Favi\u00e9","year":"2020","unstructured":"Favi\u00e9 LMA et al (2020) Pharmacokinetics and short-term safety of the selective NOS inhibitor 2-iminobiotin in asphyxiated neonates treated with therapeutic hypothermia. Pediatr Res 87(4):689\u2013696","journal-title":"Pediatr Res"},{"key":"382_CR73","doi-asserted-by":"publisher","unstructured":"Fedorov R et al (2004) Structures of nitric oxide synthase isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design. Proc Natl Acad Sci:5892\u20135897. https:\/\/doi.org\/10.1073\/pnas.0306588101","DOI":"10.1073\/pnas.0306588101"},{"key":"382_CR74","doi-asserted-by":"publisher","unstructured":"Felice MD et al (2010) Triptan-induced enhancement of neuronal nitric oxide synthase in trigeminal ganglion dural afferents underlies increased responsiveness to potential migraine triggers. Brain:2475\u20132488. https:\/\/doi.org\/10.1093\/brain\/awq159","DOI":"10.1093\/brain\/awq159"},{"key":"382_CR75","doi-asserted-by":"publisher","unstructured":"Fish JE et al (2005) The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code. J Biol Chem:24824\u201324838. https:\/\/doi.org\/10.1074\/jbc.m502115200","DOI":"10.1074\/jbc.m502115200"},{"issue":"2","key":"382_CR76","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1074\/jbc.M109.067868","volume":"285","author":"JE Fish","year":"2010","unstructured":"Fish JE et al (2010) Hypoxic repression of endothelial nitric-oxide synthase transcription is coupled with eviction of promoter histones. J Biol Chem 285(2):810\u2013826","journal-title":"J Biol Chem"},{"key":"382_CR77","doi-asserted-by":"publisher","unstructured":"Forstermann U, Sessa WC (2012) Nitric oxide synthases: regulation and function. Eur Heart J:829\u2013837. https:\/\/doi.org\/10.1093\/eurheartj\/ehr304","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"382_CR78","doi-asserted-by":"publisher","unstructured":"F\u00f6rstermann U et al (1986) Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries. Circ Res:531\u2013538. https:\/\/doi.org\/10.1161\/01.res.58.4.531","DOI":"10.1161\/01.res.58.4.531"},{"key":"382_CR79","doi-asserted-by":"publisher","unstructured":"F\u00f6rstermann U et al (1992) Induced RAW 264.7 macrophages express soluble and particulate nitric oxide synthase: inhibition by transforming growth factor-\u00df. Eur J Pharmacol Mol Pharmacol:161\u2013165. https:\/\/doi.org\/10.1016\/0922-4106(92)90096-e","DOI":"10.1016\/0922-4106(92)90096-e"},{"issue":"20","key":"382_CR80","doi-asserted-by":"crossref","first-page":"4108","DOI":"10.1021\/jm981129a","volume":"42","author":"LG Fr\u00f6hlich","year":"1999","unstructured":"Fr\u00f6hlich LG et al (1999) Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: structure-activity relationship of antagonists of (6R)-5,6,7,8-tetrahydrobiopterin cofactor. J Med Chem 42(20):4108\u20134121","journal-title":"J Med Chem"},{"issue":"11","key":"382_CR81","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1172\/JCI9551","volume":"105","author":"T Fukai","year":"2000","unstructured":"Fukai T et al (2000) Regulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training. J Clin Invest 105(11):1631\u20131639","journal-title":"J Clin Invest"},{"key":"382_CR82","doi-asserted-by":"publisher","unstructured":"Fulton DJR (2016) Transcriptional and posttranslational regulation of eNOS in the endothelium. Adv Pharmacol:29\u201364. https:\/\/doi.org\/10.1016\/bs.apha.2016.04.001","DOI":"10.1016\/bs.apha.2016.04.001"},{"issue":"43","key":"382_CR83","doi-asserted-by":"crossref","first-page":"35943","DOI":"10.1074\/jbc.M504606200","volume":"280","author":"D Fulton","year":"2005","unstructured":"Fulton D et al (2005) Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83. J Biol Chem 280(43):35943\u201335952","journal-title":"J Biol Chem"},{"key":"382_CR84","doi-asserted-by":"publisher","unstructured":"Ganster RW et al (2001) Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF- B. Proc Natl Acad Sci 98(15):8638\u20138643. https:\/\/doi.org\/10.1073\/pnas.151239498","DOI":"10.1073\/pnas.151239498"},{"key":"382_CR85","doi-asserted-by":"publisher","unstructured":"Gantner BN, LaFond KM, Bonini MG (2020) Nitric oxide in cellular adaptation and disease. Redox Biol 34:101550. https:\/\/doi.org\/10.1016\/j.redox.2020.101550","DOI":"10.1016\/j.redox.2020.101550"},{"issue":"2","key":"382_CR86","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/bph.14522","volume":"176","author":"V Garcia","year":"2019","unstructured":"Garcia V, Sessa WC (2019) Endothelial NOS: perspective and recent developments. Br J Pharmacol 176(2):189\u2013196","journal-title":"Br J Pharmacol"},{"issue":"11","key":"382_CR87","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1038\/nchembio.115","volume":"4","author":"ED Garcin","year":"2008","unstructured":"Garcin ED et al (2008) Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase. Nat Chem Biol 4(11):700\u2013707","journal-title":"Nat Chem Biol"},{"issue":"43","key":"382_CR88","doi-asserted-by":"crossref","first-page":"26669","DOI":"10.1016\/S0021-9258(18)47071-8","volume":"269","author":"EP Garvey","year":"1994","unstructured":"Garvey EP et al (1994) Potent and selective inhibition of human nitric oxide synthases. Inhibition by non-amino acid isothioureas. J Biol Chem 269(43):26669\u201326676","journal-title":"J Biol Chem"},{"issue":"8","key":"382_CR89","doi-asserted-by":"crossref","first-page":"4959","DOI":"10.1074\/jbc.272.8.4959","volume":"272","author":"EP Garvey","year":"1997","unstructured":"Garvey EP et al (1997) 1400W is a slow, tight binding, and highly selective inhibitor of inducible nitric-oxide synthase in vitro and in vivo. J Biol Chem 272(8):4959\u20134963","journal-title":"J Biol Chem"},{"key":"382_CR90","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.niox.2019.04.007","volume":"89","author":"V Gebhart","year":"2019","unstructured":"Gebhart V et al (2019) Site and mechanism of uncoupling of nitric-oxide synthase: uncoupling by monomerization and other misconceptions. Nitric Oxide Biol Chem 89:14\u201321","journal-title":"Nitric Oxide Biol Chem"},{"key":"382_CR91","doi-asserted-by":"publisher","unstructured":"Ghosh A, Chawla-Sarkar M, Stuehr DJ (2011) Hsp90 interacts with inducible NO synthase client protein in its heme-free state and then drives heme insertion by an ATP-dependent process. FASEB J:2049\u20132060. https:\/\/doi.org\/10.1096\/fj.10-180554","DOI":"10.1096\/fj.10-180554"},{"issue":"14","key":"382_CR92","doi-asserted-by":"crossref","first-page":"4228","DOI":"10.1016\/j.bmcl.2011.05.073","volume":"21","author":"U Gr\u00e4dler","year":"2011","unstructured":"Gr\u00e4dler U et al (2011) Novel nanomolar imidazo[4,5-b]pyridines as selective nitric oxide synthase (iNOS) inhibitors: SAR and structural insights. Bioorg Med Chem Lett 21(14):4228\u20134232","journal-title":"Bioorg Med Chem Lett"},{"key":"382_CR93","doi-asserted-by":"publisher","unstructured":"Grover R et al (1999) An open-label dose escalation study of the nitric oxide synthase inhibitor, NG-methyl-L-arginine hydrochloride (546C88), in patients with septic shock. Crit Care Med:913\u2013922. https:\/\/doi.org\/10.1097\/00003246-199905000-00025","DOI":"10.1097\/00003246-199905000-00025"},{"issue":"1\u20132","key":"382_CR94","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.brainres.2003.08.063","volume":"993","author":"KK Haga","year":"2003","unstructured":"Haga KK et al (2003) The neuronal nitric oxide synthase inhibitor, TRIM, as a neuroprotective agent: effects in models of cerebral ischaemia using histological and magnetic resonance imaging techniques. Brain Res 993(1\u20132):42\u201353","journal-title":"Brain Res"},{"issue":"10","key":"382_CR95","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1096\/fj.02-0633fje","volume":"17","author":"TT Hansel","year":"2003","unstructured":"Hansel TT et al (2003) A selective inhibitor of inducible nitric oxide synthase inhibits exhaled breath nitric oxide in healthy volunteers and asthmatics. FASEB J 17(10):1298\u20131300","journal-title":"FASEB J"},{"issue":"22","key":"382_CR96","doi-asserted-by":"crossref","first-page":"9254","DOI":"10.1073\/pnas.0700332104","volume":"104","author":"MM Haque","year":"2007","unstructured":"Haque MM et al (2007) A connecting hinge represses the activity of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A 104(22):9254\u20139259","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"36","key":"382_CR97","doi-asserted-by":"crossref","first-page":"30105","DOI":"10.1074\/jbc.M112.339697","volume":"287","author":"MM Haque","year":"2012","unstructured":"Haque MM et al (2012) Control of electron transfer and catalysis in neuronal nitric-oxide synthase (nNOS) by a hinge connecting its FMN and FAD-NADPH domains. J Biol Chem 287(36):30105\u201330116","journal-title":"J Biol Chem"},{"key":"382_CR98","doi-asserted-by":"publisher","unstructured":"Heiss E, Dirsch V (2014) Regulation of eNOS enzyme activity by posttranslational modification. Curr Pharm Des:3503\u20133513. https:\/\/doi.org\/10.2174\/13816128113196660745","DOI":"10.2174\/13816128113196660745"},{"issue":"2","key":"382_CR99","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1136\/annrheumdis-2012-202239","volume":"72","author":"M-P Hellio le Graverand","year":"2013","unstructured":"Hellio le Graverand M-P et al (2013) A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee. Ann Rheum Dis 72(2):187\u2013195","journal-title":"Ann Rheum Dis"},{"issue":"46","key":"382_CR100","doi-asserted-by":"crossref","first-page":"35786","DOI":"10.1074\/jbc.M005976200","volume":"275","author":"B Hemmens","year":"2000","unstructured":"Hemmens B et al (2000) Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. J Biol Chem 275(46):35786\u201335791","journal-title":"J Biol Chem"},{"issue":"11","key":"382_CR101","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1474-4422(12)70225-9","volume":"11","author":"MD Hill","year":"2012","unstructured":"Hill MD et al (2012) Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Neurol 11(11):942\u2013950","journal-title":"Lancet Neurol"},{"issue":"10227","key":"382_CR102","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0140-6736(20)30258-0","volume":"395","author":"MD Hill","year":"2020","unstructured":"Hill MD et al (2020) Efficacy and safety of nerinetide for the treatment of acute ischaemic stroke (ESCAPE-NA1): a multicentre, double-blind, randomised controlled trial. Lancet 395(10227):878\u2013887","journal-title":"Lancet"},{"issue":"1","key":"382_CR103","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1007\/s11940-011-0155-4","volume":"14","author":"J Hoffmann","year":"2012","unstructured":"Hoffmann J, Goadsby PJ (2012) New agents for acute treatment of migraine: CGRP receptor antagonists, iNOS inhibitors. Curr Treat Options Neurol 14(1):50\u201359","journal-title":"Curr Treat Options Neurol"},{"issue":"12","key":"382_CR104","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1177\/0333102410370875","volume":"30","author":"HO H\u00f8ivik","year":"2010","unstructured":"H\u00f8ivik HO et al (2010) Lack of efficacy of the selective iNOS inhibitor GW274150 in prophylaxis of migraine headache. Cephalalgia Int J headache 30(12):1458\u20131467","journal-title":"Cephalalgia Int J headache"},{"issue":"1","key":"382_CR105","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.sjpain.2012.08.002","volume":"4","author":"A Hougaard","year":"2013","unstructured":"Hougaard A et al (2013) The nitric oxide synthase inhibitor and serotonin-receptor agonist NXN-188 during the aura phase of migraine with aura: a randomized, double-blind, placebo-controlled cross-over study. Scand J Pain 4(1):48\u201352","journal-title":"Scand J Pain"},{"issue":"5180","key":"382_CR106","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1126\/science.7522345","volume":"265","author":"Z Huang","year":"1994","unstructured":"Huang Z et al (1994) Effects of cerebral ischemia in mice deficient in neuronal nitric oxide synthase. Science 265(5180):1883\u20131885","journal-title":"Science"},{"key":"382_CR107","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2172-2-11","volume":"2","author":"DA Hume","year":"2001","unstructured":"Hume DA et al (2001) Macrophages exposed continuously to lipopolysaccharide and other agonists that act via toll-like receptors exhibit a sustained and additive activation state. BMC Immunol 2:11","journal-title":"BMC Immunol"},{"issue":"6","key":"382_CR108","first-page":"H2524","volume":"285","author":"F Ichinose","year":"2003","unstructured":"Ichinose F et al (2003) A selective inducible NOS dimerization inhibitor prevents systemic, cardiac, and pulmonary hemodynamic dysfunction in endotoxemic mice. Am J Phys Heart Circ Phys 285(6):H2524\u2013H2530","journal-title":"Am J Phys Heart Circ Phys"},{"issue":"1","key":"382_CR109","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2174\/156720210790820190","volume":"7","author":"Y Ito","year":"2010","unstructured":"Ito Y et al (2010) Nitric oxide production during cerebral ischemia and reperfusion in eNOS- and nNOS-knockout mice. Curr Neurovasc Res 7(1):23\u201331","journal-title":"Curr Neurovasc Res"},{"key":"382_CR110","doi-asserted-by":"publisher","unstructured":"Jaffrey SR et al (2002) Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Proc Natl Acad Sci:3199\u20133204. https:\/\/doi.org\/10.1073\/pnas.261705799","DOI":"10.1073\/pnas.261705799"},{"issue":"2","key":"382_CR111","first-page":"275","volume":"26","author":"K J\u00e4rvinen","year":"2008","unstructured":"J\u00e4rvinen K et al (2008) Selective iNOS inhibitor 1400W enhances anti-catabolic IL-10 and reduces destructive MMP-10 in OA cartilage. Survey of the effects of 1400W on inflammatory mediators produced by OA cartilage as detected by protein antibody array. Clin Exp Rheumatol 26(2):275\u2013282","journal-title":"Clin Exp Rheumatol"},{"key":"382_CR112","first-page":"ii50","volume":"43","author":"JE Johnston","year":"2004","unstructured":"Johnston JE et al (2004) A novel inducible nitric oxide synthase (iNOS) inhibitor influences aggrecan mRNA levels in osteoarthritic (OA) chondrocytes. Rheumatology 43:ii50","journal-title":"Rheumatology"},{"key":"382_CR113","doi-asserted-by":"publisher","unstructured":"Jones LH (2012) Chemistry and biology of biomolecule nitration. Chem Biol:1086\u20131092. https:\/\/doi.org\/10.1016\/j.chembiol.2012.07.019","DOI":"10.1016\/j.chembiol.2012.07.019"},{"issue":"7","key":"382_CR114","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1161\/CIRCRESAHA.110.222968","volume":"107","author":"S-B Jung","year":"2010","unstructured":"Jung S-B et al (2010) Histone deacetylase 3 antagonizes aspirin-stimulated endothelial nitric oxide production by reversing aspirin-induced lysine acetylation of endothelial nitric oxide synthase. Circ Res 107(7):877\u2013887","journal-title":"Circ Res"},{"issue":"3","key":"382_CR115","first-page":"1128","volume":"298","author":"E Kankuri","year":"2001","unstructured":"Kankuri E et al (2001) Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine. J Pharmacol Exp Ther 298(3):1128\u20131132","journal-title":"J Pharmacol Exp Ther"},{"key":"382_CR116","doi-asserted-by":"publisher","unstructured":"Kelleher ZT et al (2007) NOS2 regulation of NF-\u03baB byS-Nitrosylation of p65. J Biol Chem:30667\u201330672. https:\/\/doi.org\/10.1074\/jbc.m705929200","DOI":"10.1074\/jbc.m705929200"},{"issue":"4","key":"382_CR117","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1161\/HYPERTENSIONAHA.114.04538","volume":"65","author":"SG Khan","year":"2015","unstructured":"Khan SG et al (2015) Impaired neuronal nitric oxide synthase-mediated vasodilator responses to mental stress in essential hypertension. Hypertension 65(4):903\u2013909","journal-title":"Hypertension"},{"key":"382_CR118","doi-asserted-by":"publisher","unstructured":"Khan SG et al (2017) The human coronary vasodilatory response to acute mental stress is mediated by neuronal nitric oxide synthase. Am J Phys Heart Circ Phys:H578\u2013H583. https:\/\/doi.org\/10.1152\/ajpheart.00745.2016","DOI":"10.1152\/ajpheart.00745.2016"},{"issue":"6","key":"382_CR119","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1164\/ajrccm.151.6.7767537","volume":"151","author":"SA Kharitonov","year":"1995","unstructured":"Kharitonov SA et al (1995) Allergen-induced late asthmatic reactions are associated with elevation of exhaled nitric oxide. Am J Respir Crit Care Med 151(6):1894\u20131899","journal-title":"Am J Respir Crit Care Med"},{"key":"382_CR120","doi-asserted-by":"publisher","unstructured":"Kielstein JT, Sydow K, Thum T (2007) Tilarginine in patients with acute myocardial infarction and cardiogenic shock. JAMA:969. https:\/\/doi.org\/10.1001\/jama.298.9.971-a","DOI":"10.1001\/jama.298.9.971-a"},{"key":"382_CR121","doi-asserted-by":"publisher","unstructured":"Kleinschnitz C et al (2016) NOS knockout or inhibition but not disrupting PSD-95-NOS interaction protect against ischemic brain damage. J Cereb Blood Flow Metab:1508\u20131512. https:\/\/doi.org\/10.1177\/0271678x16657094","DOI":"10.1177\/0271678x16657094"},{"key":"382_CR122","doi-asserted-by":"publisher","unstructured":"Knowles RG, Moncada S (1994) Nitric oxide synthases in mammals. Biochem J:249\u2013258. https:\/\/doi.org\/10.1042\/bj2980249","DOI":"10.1042\/bj2980249"},{"issue":"4","key":"382_CR123","first-page":"77","volume":"132","author":"DE Korzhevski\u012d","year":"2007","unstructured":"Korzhevski\u012d DE et al (2007) Immunocytochemical demonstration of neuronal NO-synthase in rat brain cells. Morfologiia 132(4):77\u201380","journal-title":"Morfologiia"},{"issue":"Pt 3","key":"382_CR124","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1042\/bj3400745","volume":"340","author":"P Kotsonis","year":"1999","unstructured":"Kotsonis P et al (1999) Autoinhibition of neuronal nitric oxide synthase: distinct effects of reactive nitrogen and oxygen species on enzyme activity. Biochem J 340(Pt 3):745\u2013752","journal-title":"Biochem J"},{"issue":"52","key":"382_CR125","doi-asserted-by":"crossref","first-page":"49133","DOI":"10.1074\/jbc.M011469200","volume":"276","author":"P Kotsonis","year":"2001","unstructured":"Kotsonis P et al (2001) Structural basis for pterin antagonism in nitric-oxide synthase. Development of novel 4-oxo-pteridine antagonists of (6R)-5,6,7,8-tetrahydrobiopterin. J Biol Chem 276(52):49133\u201349141","journal-title":"J Biol Chem"},{"key":"382_CR126","doi-asserted-by":"publisher","unstructured":"Kubes P, Suzuki M, Granger DN (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci:4651\u20134655. https:\/\/doi.org\/10.1073\/pnas.88.11.4651","DOI":"10.1073\/pnas.88.11.4651"},{"issue":"25","key":"382_CR127","doi-asserted-by":"crossref","first-page":"22546","DOI":"10.1074\/jbc.M302227200","volume":"278","author":"N Kuzkaya","year":"2003","unstructured":"Kuzkaya N et al (2003) Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 278(25):22546\u201322554","journal-title":"J Biol Chem"},{"issue":"6","key":"382_CR128","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ejpain.2005.07.004","volume":"10","author":"CJ LaBuda","year":"2006","unstructured":"LaBuda CJ et al (2006) Antinociceptive activity of the selective iNOS inhibitor AR-C102222 in rodent models of inflammatory, neuropathic and post-operative pain. Eur J Pain 10(6):505\u2013512","journal-title":"Eur J Pain"},{"issue":"7","key":"382_CR129","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.leukres.2007.11.026","volume":"32","author":"MC Levesque","year":"2008","unstructured":"Levesque MC et al (2008) CLL cell apoptosis induced by nitric oxide synthase inhibitors: correlation with lipid solubility and NOS1 dissociation constant. Leuk Res 32(7):1061\u20131070","journal-title":"Leuk Res"},{"key":"382_CR130","doi-asserted-by":"publisher","unstructured":"Li H et al (1999) Crystal structures of zinc-free and -bound heme domain of human inducible nitric-oxide synthase. J Biol Chem:21276\u201321284. https:\/\/doi.org\/10.1074\/jbc.274.30.21276","DOI":"10.1074\/jbc.274.30.21276"},{"issue":"46","key":"382_CR131","doi-asserted-by":"crossref","first-page":"15222","DOI":"10.1021\/bi0513610","volume":"44","author":"H Li","year":"2005","unstructured":"Li H et al (2005) Exploring the binding conformations of bulkier dipeptide amide inhibitors in constitutive nitric oxide synthases. Biochemistry 44(46):15222\u201315229","journal-title":"Biochemistry"},{"issue":"6","key":"382_CR132","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/HJH.0000000000000587","volume":"33","author":"Q Li","year":"2015","unstructured":"Li Q, Youn J-Y, Cai H (2015) Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension. J Hypertens 33(6):1128\u20131136","journal-title":"J Hypertens"},{"key":"382_CR133","doi-asserted-by":"publisher","unstructured":"Lin MI et al (2003) Phosphorylation of threonine 497 in endothelial nitric-oxide synthase coordinates the coupling of l-arginine metabolism to efficient nitric oxide production. J Biol Chem:44719\u201344726. https:\/\/doi.org\/10.1074\/jbc.m302836200","DOI":"10.1074\/jbc.m302836200"},{"issue":"3","key":"382_CR134","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.4049\/jimmunol.1102527","volume":"188","author":"AC Liu","year":"2012","unstructured":"Liu AC et al (2012) Induction of endothelial nitric oxide synthase expression by IL-17 in human vascular endothelial cells: implications for vascular remodeling in transplant vasculopathy. J Immunol 188(3):1544\u20131550","journal-title":"J Immunol"},{"issue":"13","key":"382_CR135","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1084\/jem.20090449","volume":"206","author":"AE Loot","year":"2009","unstructured":"Loot AE et al (2009) Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase. J Exp Med 206(13):2889\u20132896","journal-title":"J Exp Med"},{"issue":"1","key":"382_CR136","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.CCM.0000105581.01815.C6","volume":"32","author":"A L\u00f3pez","year":"2004","unstructured":"L\u00f3pez A et al (2004) Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med 32(1):21\u201330","journal-title":"Crit Care Med"},{"issue":"7","key":"382_CR137","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/s41419-019-1731-x","volume":"10","author":"P Luo","year":"2019","unstructured":"Luo P et al (2019) Preso regulates NMDA receptor-mediated excitotoxicity via modulating nitric oxide and calcium responses after traumatic brain injury. Cell Death Dis 10(7):496","journal-title":"Cell Death Dis"},{"key":"382_CR138","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev.immunol.15.1.323","volume":"15","author":"J MacMicking","year":"1997","unstructured":"MacMicking J, Xie QW, Nathan C (1997) Nitric oxide and macrophage function. Annu Rev Immunol 15:323\u2013350","journal-title":"Annu Rev Immunol"},{"key":"382_CR139","doi-asserted-by":"publisher","unstructured":"Mallinder PR, Wallace AV, Allenby G (2009) Identification of iNOS inhibitors using InteraX\u2122. J Biomol Screen:263\u2013272. https:\/\/doi.org\/10.1177\/1087057109331476","DOI":"10.1177\/1087057109331476"},{"key":"382_CR140","doi-asserted-by":"publisher","unstructured":"Man HSJ et al (2018) Angiogenic patterning by STEEL, an endothelial-enriched long noncoding RNA. Proc Natl Acad Sci:2401\u20132406. https:\/\/doi.org\/10.1073\/pnas.1715182115","DOI":"10.1073\/pnas.1715182115"},{"key":"382_CR141","doi-asserted-by":"publisher","unstructured":"Masters BSS et al (1996) Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO as a cellular signal. FASEB J:552\u2013558. https:\/\/doi.org\/10.1096\/fasebj.10.5.8621055","DOI":"10.1096\/fasebj.10.5.8621055"},{"key":"382_CR142","doi-asserted-by":"publisher","unstructured":"Matsumoto M (2013) Faculty opinions recommendation of safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial. Faculty Opin Post Publ Peer Rev Biomed Lit. https:\/\/doi.org\/10.3410\/f.717961804.793478082","DOI":"10.3410\/f.717961804.793478082"},{"issue":"14","key":"382_CR143","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1021\/jm020074g","volume":"45","author":"H Matter","year":"2002","unstructured":"Matter H et al (2002) Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors. J Med Chem 45(14):2923\u20132941","journal-title":"J Med Chem"},{"issue":"15","key":"382_CR144","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1021\/jm050007x","volume":"48","author":"H Matter","year":"2005","unstructured":"Matter H et al (2005) Structural analysis of isoform-specific inhibitors targeting the tetrahydrobiopterin binding site of human nitric oxide synthases. J Med Chem 48(15):4783\u20134792","journal-title":"J Med Chem"},{"key":"382_CR145","doi-asserted-by":"crossref","first-page":"478","DOI":"10.3389\/fimmu.2014.00478","volume":"5","author":"JT Mattila","year":"2014","unstructured":"Mattila JT, Thomas AC (2014) Nitric oxide synthase: non-canonical expression patterns. Front Immunol 5:478","journal-title":"Front Immunol"},{"issue":"8","key":"382_CR146","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.tcm.2010.02.007","volume":"19","author":"N Melikian","year":"2009","unstructured":"Melikian N et al (2009) Neuronal nitric oxide synthase and human vascular regulation. Trends Cardiovasc Med 19(8):256\u2013262","journal-title":"Trends Cardiovasc Med"},{"issue":"7","key":"382_CR147","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/PL00000317","volume":"51","author":"AF Mendes","year":"2002","unstructured":"Mendes AF et al (2002) Role of nitric oxide in the activation of NF-kappaB, AP-1 and NOS II expression in articular chondrocytes. Inflam Res 51(7):369\u2013375","journal-title":"Inflam Res"},{"key":"382_CR148","doi-asserted-by":"publisher","unstructured":"Mercer PF et al (2015) Translational models of lung disease. Clin Sci:235\u2013256. https:\/\/doi.org\/10.1042\/cs20140373","DOI":"10.1042\/cs20140373"},{"issue":"6","key":"382_CR149","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1161\/01.STR.29.6.1248","volume":"29","author":"K Nanri","year":"1998","unstructured":"Nanri K et al (1998) The selective inhibitor of neuronal nitric oxide synthase, 7-nitroindazole, reduces the delayed neuronal damage due to forebrain ischemia in rats. Stroke 29(6):1248\u20131253; discussion 1253\u20134","journal-title":"Stroke"},{"key":"382_CR150","doi-asserted-by":"publisher","unstructured":"Nathan C (2006) Role of iNOS in human host defense. Science:1874b\u20131875b. https:\/\/doi.org\/10.1126\/science.312.5782.1874b","DOI":"10.1126\/science.312.5782.1874b"},{"key":"382_CR151","doi-asserted-by":"crossref","unstructured":"Nedvetsky PI, Sessa WC, Schmidt HHHW (2002) There\u2019s NO binding like NOS binding: protein-protein interactions in NO\/cGMP signaling. Proc Natl Acad Sci U S A:16510\u201316512","DOI":"10.1073\/pnas.262701999"},{"issue":"5","key":"382_CR152","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1172\/JCI116092","volume":"90","author":"K Nishida","year":"1992","unstructured":"Nishida K et al (1992) Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J Clin Invest 90(5):2092\u20132096","journal-title":"J Clin Invest"},{"key":"382_CR153","doi-asserted-by":"publisher","unstructured":"O\u2019Dell T et al (1994) Endothelial NOS and the blockade of LTP by NOS inhibitors in mice lacking neuronal NOS. Science:542\u2013546. https:\/\/doi.org\/10.1126\/science.7518615","DOI":"10.1126\/science.7518615"},{"issue":"2","key":"382_CR154","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(00)02471-9","volume":"871","author":"MJ O\u2019Neill","year":"2000","unstructured":"O\u2019Neill MJ et al (2000) ARL 17477, a selective nitric oxide synthase inhibitor, with neuroprotective effects in animal models of global and focal cerebral ischaemia. Brain Res 871(2):234\u2013244","journal-title":"Brain Res"},{"key":"382_CR155","doi-asserted-by":"publisher","unstructured":"Ohtsuka M et al (2002) PPA250 [3-(2,4-Difluorophenyl)-6\u20132-[4-(1H-imidazol-1-ylmethyl) Phenoxy]ethoxy-2-phenylpyridine], a novel orally effective inhibitor of the dimerization of inducible nitric-oxide synthase, exhibits an anti-inflammatory effect in animal models of chronic arthritis. J Pharmacol Exp Ther:52\u201357. https:\/\/doi.org\/10.1124\/jpet.102.035857","DOI":"10.1124\/jpet.102.035857"},{"key":"382_CR156","doi-asserted-by":"publisher","unstructured":"Ota KT et al (2010) Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learn Mem:221\u2013235. https:\/\/doi.org\/10.1101\/lm.1592510","DOI":"10.1101\/lm.1592510"},{"issue":"5","key":"382_CR157","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1111\/bcp.13870","volume":"85","author":"C Ott","year":"2019","unstructured":"Ott C et al (2019) Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers. Br J Clin Pharmacol 85(5):900\u2013907","journal-title":"Br J Clin Pharmacol"},{"key":"382_CR158","doi-asserted-by":"publisher","unstructured":"Ouyang J et al (2005) Effect of a novel inducible nitric oxide synthase inhibitor in prevention of rat chronic aortic rejections. Transplantation:1386\u20131392. https:\/\/doi.org\/10.1097\/01.tp.0000159144.08519.e2","DOI":"10.1097\/01.tp.0000159144.08519.e2"},{"issue":"1","key":"382_CR159","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","volume":"87","author":"P Pacher","year":"2007","unstructured":"Pacher P, Beckman JS, Liaudet L (2007) Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87(1):315\u2013424","journal-title":"Physiol Rev"},{"key":"382_CR160","doi-asserted-by":"publisher","unstructured":"Pan J et al (1996) Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation. Biochem J:889\u2013894. https:\/\/doi.org\/10.1042\/bj3140889","DOI":"10.1042\/bj3140889"},{"issue":"Pt 1","key":"382_CR161","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1042\/bj3560043","volume":"356","author":"MM Pantke","year":"2001","unstructured":"Pantke MM et al (2001) Pterin interactions with distinct reductase activities of NO synthase. Biochem J 356(Pt 1):43\u201351","journal-title":"Biochem J"},{"key":"382_CR162","doi-asserted-by":"publisher","unstructured":"Peng H-M et al (2012) Modulation of Heme\/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS Ubiquitination. J Biol Chem:1556\u20131565. https:\/\/doi.org\/10.1074\/jbc.m111.323295","DOI":"10.1074\/jbc.m111.323295"},{"key":"382_CR163","doi-asserted-by":"publisher","unstructured":"Percival JM (2011) nNOS regulation of skeletal muscle fatigue and exercise performance. Biophys Rev:209\u2013217. https:\/\/doi.org\/10.1007\/s12551-011-0060-9","DOI":"10.1007\/s12551-011-0060-9"},{"issue":"2","key":"382_CR164","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.nbd.2004.10.018","volume":"18","author":"FJ P\u00e9rez-Asensio","year":"2005","unstructured":"P\u00e9rez-Asensio FJ et al (2005) Inhibition of iNOS activity by 1400W decreases glutamate release and ameliorates stroke outcome after experimental ischemia. Neurobiol Dis 18(2):375\u2013384","journal-title":"Neurobiol Dis"},{"issue":"1","key":"382_CR165","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1093\/cvr\/28.1.34","volume":"28","author":"A Petros","year":"1994","unstructured":"Petros A et al (1994) Effects of a nitric oxide synthase inhibitor in humans with septic shock. Cardiovasc Res 28(1):34\u201339","journal-title":"Cardiovasc Res"},{"issue":"6","key":"382_CR166","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1476-5381.1996.tb15557.x","volume":"118","author":"S Pfeiffer","year":"1996","unstructured":"Pfeiffer S et al (1996) Inhibition of nitric oxide synthesis by NG-nitro-L-arginine methyl ester (L-NAME): requirement for bioactivation to the free acid, NG-nitro-L-arginine. Br J Pharmacol 118(6):1433\u20131440","journal-title":"Br J Pharmacol"},{"key":"382_CR167","doi-asserted-by":"publisher","unstructured":"Raman CS et al (1998) Crystal structure of constitutive endothelial nitric oxide synthase. Cell:939\u2013950. https:\/\/doi.org\/10.1016\/s0092-8674(00)81718-3","DOI":"10.1016\/s0092-8674(00)81718-3"},{"key":"382_CR168","doi-asserted-by":"publisher","unstructured":"Ramasamy S et al (2014) Probing the mechanism of tetrahydrobiopterin radical reduction within NO synthases. Nitric Oxide:138\u2013139. https:\/\/doi.org\/10.1016\/j.niox.2014.09.118","DOI":"10.1016\/j.niox.2014.09.118"},{"issue":"35","key":"382_CR169","doi-asserted-by":"crossref","first-page":"24921","DOI":"10.1074\/jbc.274.35.24921","volume":"274","author":"A Reif","year":"1999","unstructured":"Reif A et al (1999) Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase. J Biol Chem 274(35):24921\u201324929","journal-title":"J Biol Chem"},{"key":"382_CR170","doi-asserted-by":"publisher","unstructured":"Reif DW et al (2000) Discovery and development of neuronal nitric oxide synthase inhibitors. Free Rad Biol Med:1470\u20131477. https:\/\/doi.org\/10.1016\/s0891-5849(00)00250-1","DOI":"10.1016\/s0891-5849(00)00250-1"},{"key":"382_CR171","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/1471-2164-8-271","volume":"8","author":"D Rico","year":"2007","unstructured":"Rico D et al (2007) Identification of conserved domains in the promoter regions of nitric oxide synthase 2: implications for the species-specific transcription and evolutionary differences. BMC Genom 8:271","journal-title":"BMC Genom"},{"issue":"47","key":"382_CR172","doi-asserted-by":"crossref","first-page":"13915","DOI":"10.1021\/bi026313j","volume":"41","author":"RJ Rosenfeld","year":"2002","unstructured":"Rosenfeld RJ et al (2002a) Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency. Biochemistry 41(47):13915\u201313925","journal-title":"Biochemistry"},{"key":"382_CR173","doi-asserted-by":"publisher","unstructured":"Rosenfeld RJ et al (2002b) Human endothelial nitric oxide synthase with 5-nitroindazole bound. https:\/\/doi.org\/10.2210\/pdb1m9q\/pdb","DOI":"10.2210\/pdb1m9q\/pdb"},{"key":"382_CR174","doi-asserted-by":"publisher","unstructured":"Rosenfeld RJ et al (2002c) Human endothelial nitric oxide synthase with 6-nitroindazole bound. https:\/\/doi.org\/10.2210\/pdb1m9m\/pdb","DOI":"10.2210\/pdb1m9m\/pdb"},{"key":"382_CR175","doi-asserted-by":"publisher","unstructured":"Rosenfeld RJ et al (2002d) Human endothelial nitric oxide synthase with 7-Nitroindazole bound. https:\/\/doi.org\/10.2210\/pdb1m9k\/pdb","DOI":"10.2210\/pdb1m9k\/pdb"},{"key":"382_CR176","doi-asserted-by":"publisher","unstructured":"Rosenfeld RJ et al (2002e) Inducible nitric oxide synthase with 5-nitroindazole bound. https:\/\/doi.org\/10.2210\/pdb1m8i\/pdb","DOI":"10.2210\/pdb1m8i\/pdb"},{"issue":"3","key":"382_CR177","first-page":"136","volume":"11","author":"R Salem","year":"2007","unstructured":"Salem R, Mebazaa A (2007) Nitric oxide inhibition rapidly increases blood pressure with no change in outcome in cardiogenic shock: the TRIUMPH trial. Crit Care Soc Crit Care Med 11(3):136","journal-title":"Crit Care Soc Crit Care Med"},{"key":"382_CR178","doi-asserted-by":"publisher","unstructured":"Salerno JC et al (1997) An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase. J Biol Chem:29769\u201329777. https:\/\/doi.org\/10.1074\/jbc.272.47.29769","DOI":"10.1074\/jbc.272.47.29769"},{"issue":"3","key":"382_CR179","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1111\/j.1365-201X.2004.01296.x","volume":"181","author":"P Sandstrom","year":"2004","unstructured":"Sandstrom P et al (2004) Highly selective iNOS inhibition and sphincter of Oddi motility in the Australian possum. Acta Physiol Scand 181(3):321\u2013331","journal-title":"Acta Physiol Scand"},{"issue":"1","key":"382_CR180","first-page":"e10","volume":"30","author":"P Sandstrom","year":"2005","unstructured":"Sandstrom P et al (2005) Highly selective inhibition of inducible nitric oxide synthase ameliorates experimental acute pancreatitis. Pancreas 30(1):e10\u2013e15","journal-title":"Pancreas"},{"key":"382_CR181","doi-asserted-by":"publisher","unstructured":"Sattler R, Tymianski M (2000) Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med:3\u201313. https:\/\/doi.org\/10.1007\/s001090000077","DOI":"10.1007\/s001090000077"},{"key":"382_CR182","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.phrs.2015.08.001","volume":"100","author":"K Scheschowitsch","year":"2015","unstructured":"Scheschowitsch K et al (2015) Rapid NOS-1-derived nitric oxide and peroxynitrite formation act as signaling agents for inducible NOS-2 expression in vascular smooth muscle cells. Pharmacol Res 100:73\u201384","journal-title":"Pharmacol Res"},{"key":"382_CR183","doi-asserted-by":"publisher","unstructured":"Schinzel R, Tegtmeier F (2017) Nitric oxide synthase inhibitors in traumatic brain injury. New Ther Traumatic Brain Injury:133\u2013144. https:\/\/doi.org\/10.1016\/b978-0-12-802686-1.00008-0","DOI":"10.1016\/b978-0-12-802686-1.00008-0"},{"key":"382_CR184","doi-asserted-by":"publisher","unstructured":"Schleicher M et al (2009) The Akt1-eNOS Axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal:ra41. https:\/\/doi.org\/10.1126\/scisignal.2000343","DOI":"10.1126\/scisignal.2000343"},{"issue":"2","key":"382_CR185","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0014-2999(88)90101-X","volume":"154","author":"HH Schmidt","year":"1988","unstructured":"Schmidt HH et al (1988) Arginine is a physiological precursor of endothelium-derived nitric oxide. Eur J Pharmacol 154(2):213\u2013216","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"382_CR186","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1073\/pnas.88.2.365","volume":"88","author":"HH Schmidt","year":"1991","unstructured":"Schmidt HH et al (1991) Purification of a soluble isoform of guanylyl cyclase-activating-factor synthase. Proc Natl Acad Sci U S A 88(2):365\u2013369","journal-title":"Proc Natl Acad Sci U S A"},{"key":"382_CR187","doi-asserted-by":"publisher","unstructured":"Schmidt HHHW et al (1992) Calcium\/calmodulin-dependent nitric oxide synthase type I: a biopteroflavoprotein with calcium\/calmodulin-independent diaphorase and reductase activities. Biochemistry:3243\u20133249. https:\/\/doi.org\/10.1021\/bi00127a028","DOI":"10.1021\/bi00127a028"},{"key":"382_CR188","doi-asserted-by":"publisher","unstructured":"Schmidt HHHW, Harald HH, Walter U (1994) NO at work. Cell:919\u2013925. https:\/\/doi.org\/10.1016\/0092-8674(94)90267-4","DOI":"10.1016\/0092-8674(94)90267-4"},{"issue":"5","key":"382_CR189","doi-asserted-by":"crossref","first-page":"C803","DOI":"10.1152\/ajpcell.00457.2005","volume":"291","author":"CD Searles","year":"2006","unstructured":"Searles CD (2006) Transcriptional and posttranscriptional regulation of endothelial nitric oxide synthase expression. Am J Physiol Cell Physiol 291(5):C803\u2013C816","journal-title":"Am J Physiol Cell Physiol"},{"issue":"15","key":"382_CR190","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/CIRCULATIONAHA.107.744540","volume":"117","author":"MD Seddon","year":"2008","unstructured":"Seddon MD et al (2008) Neuronal nitric oxide synthase regulates basal microvascular tone in humans in vivo. Circulation 117(15):1991\u20131996","journal-title":"Circulation"},{"issue":"20","key":"382_CR191","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.1161\/CIRCULATIONAHA.108.822205","volume":"119","author":"M Seddon","year":"2009","unstructured":"Seddon M et al (2009) Effects of neuronal nitric oxide synthase on human coronary artery diameter and blood flow in vivo. Circulation 119(20):2656\u20132662","journal-title":"Circulation"},{"issue":"2","key":"382_CR192","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1074\/jbc.274.2.930","volume":"274","author":"N Sennequier","year":"1999","unstructured":"Sennequier N, Wolan D, Stuehr DJ (1999) Antifungal imidazoles block assembly of inducible NO synthase into an active dimer. J Biol Chem 274(2):930\u2013938","journal-title":"J Biol Chem"},{"issue":"2","key":"382_CR193","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1161\/01.RES.74.2.349","volume":"74","author":"WC Sessa","year":"1994","unstructured":"Sessa WC et al (1994) Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ Res 74(2):349\u2013353","journal-title":"Circ Res"},{"issue":"2","key":"382_CR194","first-page":"254","volume":"30","author":"M Seymour","year":"2012","unstructured":"Seymour M et al (2012) Ultrasonographic measures of synovitis in an early phase clinical trial: a double-blind, randomised, placebo and comparator controlled phase IIa trial of GW274150 (a selective inducible nitric oxide synthase inhibitor) in rheumatoid arthritis. Clin Exp Rheumatol 30(2):254\u2013261","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"382_CR195","doi-asserted-by":"crossref","first-page":"H1277","DOI":"10.1152\/ajpheart.00927.2012","volume":"304","author":"H Shabeeh","year":"2013","unstructured":"Shabeeh H et al (2013) Differential role of endothelial versus neuronal nitric oxide synthase in the regulation of coronary blood flow during pacing-induced increases in cardiac workload. Am J Physiol Heart Circulat Physiol 304(9):H1277\u2013H1282","journal-title":"Am J Physiol Heart Circulat Physiol"},{"issue":"5","key":"382_CR196","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.116.08792","volume":"69","author":"H Shabeeh","year":"2017","unstructured":"Shabeeh H et al (2017) Blood pressure in healthy humans is regulated by neuronal NO synthase. Hypertension 69(5):970\u2013976","journal-title":"Hypertension"},{"issue":"6","key":"382_CR197","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbagen.2011.07.010","volume":"1820","author":"N Shahani","year":"2012","unstructured":"Shahani N, Sawa A (2012) Protein S-nitrosylation: role for nitric oxide signaling in neuronal death. Biochim Biophys Acta 1820(6):736\u2013742","journal-title":"Biochim Biophys Acta"},{"key":"382_CR198","doi-asserted-by":"publisher","unstructured":"Sherman PA et al (1993) Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line. Biochemistry:11600\u201311605. https:\/\/doi.org\/10.1021\/bi00094a017","DOI":"10.1021\/bi00094a017"},{"issue":"10","key":"382_CR199","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1164\/rccm.200704-588OC","volume":"176","author":"D Singh","year":"2007","unstructured":"Singh D et al (2007) Selective inducible nitric oxide synthase inhibition has no effect on allergen challenge in asthma. Am J Respir Crit Care Med 176(10):988\u2013993","journal-title":"Am J Respir Crit Care Med"},{"key":"382_CR200","doi-asserted-by":"publisher","unstructured":"Smith AD et al (2005) Use of exhaled nitric oxide measurements to guide treatment in chronic asthma. New Engl J Med:2163\u20132173. https:\/\/doi.org\/10.1056\/nejmoa043596","DOI":"10.1056\/nejmoa043596"},{"key":"382_CR201","doi-asserted-by":"publisher","unstructured":"Smith BC et al (2013) Nitric oxide synthase domain interfaces regulate electron transfer and calmodulin activation. Proc Natl Acad Sci:E3577\u2013E3586. https:\/\/doi.org\/10.1073\/pnas.1313331110","DOI":"10.1073\/pnas.1313331110"},{"key":"382_CR202","doi-asserted-by":"publisher","unstructured":"Song Y, Zweier JL, Yong XIA (2001) Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2 \/calmodulin binding. Biochem J 357. https:\/\/doi.org\/10.1042\/0264-6021:3550357","DOI":"10.1042\/0264-6021:3550357"},{"issue":"19","key":"382_CR203","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1089\/neu.2014.3344","volume":"31","author":"JF Stover","year":"2014","unstructured":"Stover JF et al (2014) Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized phase IIa trial (NOSTRA). J Neurotrauma 31(19):1599\u20131606","journal-title":"J Neurotrauma"},{"issue":"2","key":"382_CR204","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bph.14533","volume":"176","author":"DJ Stuehr","year":"2019","unstructured":"Stuehr DJ, Haque MM (2019) Nitric oxide synthase enzymology in the 20 years after the Nobel prize. Br J Pharmacol 176(2):177\u2013188","journal-title":"Br J Pharmacol"},{"key":"382_CR205","doi-asserted-by":"publisher","unstructured":"Stuehr D, Pou S, Rosen GM (2001) Oxygen reduction by nitric-oxide synthases. J Biol Chem:14533\u201314536. https:\/\/doi.org\/10.1074\/jbc.r100011200","DOI":"10.1074\/jbc.r100011200"},{"issue":"18","key":"382_CR206","doi-asserted-by":"crossref","first-page":"2392","DOI":"10.1161\/01.CIR.0000034719.08848.26","volume":"106","author":"MJ Szabolcs","year":"2002","unstructured":"Szabolcs MJ et al (2002) Effects of selective inhibitors of nitric oxide synthase-2 dimerization on acute cardiac allograft rejection. Circulation 106(18):2392\u20132396","journal-title":"Circulation"},{"key":"382_CR207","doi-asserted-by":"publisher","unstructured":"Teerlink T (2007) Tilarginine in patients with acute myocardial infarction and cardiogenic shock. JAMA:969. https:\/\/doi.org\/10.1001\/jama.298.9.971-b","DOI":"10.1001\/jama.298.9.971-b"},{"issue":"1","key":"382_CR208","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s13063-020-4107-8","volume":"21","author":"F Tegtmeier","year":"2020","unstructured":"Tegtmeier F et al (2020a) Correction to: efficacy of Ronopterin (VAS203) in patients with moderate and severe traumatic brain injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised, double blind, multi-Centre study. Trials 21(1):172","journal-title":"Trials"},{"issue":"1","key":"382_CR209","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13063-019-3965-4","volume":"21","author":"F Tegtmeier","year":"2020","unstructured":"Tegtmeier F et al (2020b) Efficacy of Ronopterin (VAS203) in patients with moderate and severe traumatic brain injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind, multi-centre study. Trials 21(1):80","journal-title":"Trials"},{"key":"382_CR210","doi-asserted-by":"publisher","unstructured":"Thomas SR, Chen K, Keaney JF (2002) Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem:6017\u20136024. https:\/\/doi.org\/10.1074\/jbc.m109107200","DOI":"10.1074\/jbc.m109107200"},{"issue":"15","key":"382_CR211","first-page":"3300","volume":"57","author":"LL Thomsen","year":"1997","unstructured":"Thomsen LL et al (1997) Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor. Cancer Res 57(15):3300\u20133304","journal-title":"Cancer Res"},{"key":"382_CR212","doi-asserted-by":"publisher","unstructured":"Tinker A, Wallace A (2006) Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases? Curr Top Med Chem:77\u201392. https:\/\/doi.org\/10.2174\/156802606775270297","DOI":"10.2174\/156802606775270297"},{"key":"382_CR213","doi-asserted-by":"publisher","unstructured":"Tinker AC et al (2003) 1,2-dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo. J Med Chem:913\u2013916. https:\/\/doi.org\/10.1021\/jm0255926","DOI":"10.1021\/jm0255926"},{"issue":"4","key":"382_CR214","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1124\/mol.107.041319","volume":"73","author":"M Tiso","year":"2008","unstructured":"Tiso M et al (2008) BYK191023 (2-[2-(4-methoxy-pyridin-2-yl)-ethyl]-3h-imidazo[4,5-b]pyridine) is an NADPH- and time-dependent irreversible inhibitor of inducible nitric-oxide synthase. Mol Pharmacol 73(4):1244\u20131253","journal-title":"Mol Pharmacol"},{"issue":"15","key":"382_CR215","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1001\/jama.297.15.joc70035","volume":"297","author":"TRIUMPH Investigators","year":"2007","unstructured":"TRIUMPH Investigators et al (2007) Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: the TRIUMPH randomized controlled trial. JAMA 297(15):1657\u20131666","journal-title":"JAMA"},{"issue":"1","key":"382_CR216","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0003-4975(98)01363-0","volume":"67","author":"EE Tseng","year":"1999","unstructured":"Tseng EE et al (1999) Nitric oxide mediates neurologic injury after hypothermic circulatory arrest. Ann Thorac Surg 67(1):65\u201371","journal-title":"Ann Thorac Surg"},{"key":"382_CR217","doi-asserted-by":"crossref","unstructured":"Vamvakas S, Schmidt HH (1997) Just say NO to cancer? J Natl Cancer Inst:406\u2013407","DOI":"10.1093\/jnci\/89.6.406"},{"issue":"3","key":"382_CR218","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/0091270008329548","volume":"49","author":"BJ Van der Schueren","year":"2009","unstructured":"Van der Schueren BJ et al (2009) Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine? J Clin Pharmacol 49(3):281\u2013290","journal-title":"J Clin Pharmacol"},{"key":"382_CR219","doi-asserted-by":"publisher","unstructured":"van Hoogdalem E-J et al (2019) First-in-human study of the safety, tolerability, pharmacokinetics and - preliminary dynamics of neuroprotectant 2-iminobiotin in healthy subjects. Curr Clin Pharmacol. https:\/\/doi.org\/10.2174\/1574884714666191017111109","DOI":"10.2174\/1574884714666191017111109"},{"issue":"1","key":"382_CR220","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.clinthera.2010.01.006","volume":"32","author":"D Vaughan","year":"2010","unstructured":"Vaughan D et al (2010) Safety and pharmacokinetics of NXN-188 after single and multiple doses in five phase I, randomized, double-blind, parallel studies in healthy adult volunteers. Clin Ther 32(1):146\u2013160","journal-title":"Clin Ther"},{"issue":"7","key":"382_CR221","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1053\/joca.2001.0431","volume":"9","author":"K Vuolteenaho","year":"2001","unstructured":"Vuolteenaho K et al (2001) Regulation of the nitric oxide production resulting from the glucocorticoid-insensitive expression of iNOS in human osteoarthritic cartilage. Osteoarthritis Cartilage OARS Osteoarthritis Res Soc 9(7):597\u2013605","journal-title":"Osteoarthritis Cartilage OARS Osteoarthritis Res Soc"},{"key":"382_CR222","doi-asserted-by":"crossref","unstructured":"Wei X et al (2020) Direct current electric field stimulates nitric oxide production and promotes NO-dependent angiogenesis: involvement of the PI3K\/Akt signaling pathway. Journal of vascular research, pp.:1\u201311","DOI":"10.1159\/000506517"},{"issue":"3","key":"382_CR223","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1182\/blood.V86.3.1184.1184","volume":"86","author":"JB Weinberg","year":"1995","unstructured":"Weinberg JB et al (1995) Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. Blood 86(3):1184\u20131195","journal-title":"Blood"},{"key":"382_CR224","doi-asserted-by":"publisher","unstructured":"Werner ER, Schmidt HHW (2000) Nitric-oxide-synthase inhibitors II \u2014 Pterin antagonists\/anti-pterins. Nitric Oxide:137\u2013158. https:\/\/doi.org\/10.1007\/978-3-642-57077-3_7","DOI":"10.1007\/978-3-642-57077-3_7"},{"issue":"3","key":"382_CR225","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.freeradbiomed.2005.03.028","volume":"39","author":"M Willmot","year":"2005","unstructured":"Willmot M et al (2005) Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review. Free Radic Biol Med 39(3):412\u2013425","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"382_CR226","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1111\/j.1365-2982.2007.00940.x","volume":"19","author":"CM Woods","year":"2007","unstructured":"Woods CM et al (2007) Selective iNOS inhibition enhances spontaneous gallbladder motility in the Australian possum. Neurogastroenterol Mot 19(6):497\u2013503","journal-title":"Neurogastroenterol Mot"},{"key":"382_CR227","doi-asserted-by":"publisher","unstructured":"Wynia-Smith SL, Smith BC (2017) Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases. Nitric Oxide:52\u201360. https:\/\/doi.org\/10.1016\/j.niox.2016.10.001","DOI":"10.1016\/j.niox.2016.10.001"},{"key":"382_CR228","doi-asserted-by":"publisher","unstructured":"Yuan Z et al (2004) Evidence of nuclear localization of neuronal nitric oxide synthase in cultured astrocytes of rats. Life Sci:3199\u20133209. https:\/\/doi.org\/10.1016\/j.lfs.2003.10.037","DOI":"10.1016\/j.lfs.2003.10.037"},{"key":"382_CR229","doi-asserted-by":"publisher","unstructured":"Zamora R, Vodovotz Y, Billiar TR (2000) Inducible nitric oxide synthase and inflammatory diseases. Mol Med:347\u2013373. https:\/\/doi.org\/10.1007\/bf03401781","DOI":"10.1007\/bf03401781"},{"issue":"4","key":"382_CR230","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1097\/00004647-199607000-00009","volume":"16","author":"ZG Zhang","year":"1996","unstructured":"Zhang ZG et al (1996) ARL 17477, a potent and selective neuronal NOS inhibitor decreases infarct volume after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 16(4):599\u2013604","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"382_CR231","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.niox.2009.03.001","volume":"20","author":"L Zhou","year":"2009","unstructured":"Zhou L, Zhu D-Y (2009) Neuronal nitric oxide synthase: structure, subcellular localization, regulation, and clinical implications. Nitric Oxide Biol Chem 20(4):223\u2013230","journal-title":"Nitric Oxide Biol Chem"},{"issue":"12","key":"382_CR232","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/nm.2245","volume":"16","author":"L Zhou","year":"2010","unstructured":"Zhou L et al (2010) Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95. Nat Med 16(12):1439\u20131443","journal-title":"Nat Med"},{"key":"382_CR233","doi-asserted-by":"crossref","first-page":"971","DOI":"10.3389\/fphar.2017.00971","volume":"8","author":"K Zitta","year":"2017","unstructured":"Zitta K et al (2017) 2-Iminobiotin superimposed on hypothermia protects human neuronal cells from hypoxia-induced cell damage: an study. Front Pharmacol 8:971","journal-title":"Front Pharmacol"}],"container-title":["Handbook of Experimental Pharmacology","Reactive Oxygen Species"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2020_382","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,23]],"date-time":"2021-02-23T13:23:37Z","timestamp":1614086617000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/164_2020_382"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"ISBN":["9783030685096","9783030685102"],"references-count":233,"URL":"https:\/\/doi.org\/10.1007\/164_2020_382","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020]]},"assertion":[{"value":"15 August 2020","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}