{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T06:23:52Z","timestamp":1774592632787,"version":"3.50.1"},"publisher-location":"Cham","reference-count":138,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783030829834","type":"print"},{"value":"9783030829841","type":"electronic"}],"license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021]]},"DOI":"10.1007\/164_2021_463","type":"book-chapter","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T23:32:35Z","timestamp":1635291155000},"page":"41-80","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Organic Cation Transporter Expression and Function in the CNS"],"prefix":"10.1007","author":[{"given":"Douglas H.","family":"Sweet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"463_CR1","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1093\/oxfordjournals.molbev.a004044","volume":"19","author":"Y Acimovic","year":"2002","unstructured":"Acimovic Y, Coe RC (2002) Molecular evolution of the equilibrative nucleoside transporter family: identification of novel family members in prokaryotes and eukaryotes. Mol Biol Evol 19:2199\u20132210","journal-title":"Mol Biol Evol"},{"key":"463_CR2","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1124\/dmd.105.006932","volume":"34","author":"Y Alnouti","year":"2006","unstructured":"Alnouti Y, Petrick JS, Klaassen CD (2006) Tissue distribution and ontogeny of organic cation transporters in mice. Drug Metab Dispos 34:477\u2013482. https:\/\/doi.org\/10.1124\/dmd.105.006932","journal-title":"Drug Metab Dispos"},{"key":"463_CR3","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.neuropharm.2006.01.005","volume":"50","author":"A Amphoux","year":"2006","unstructured":"Amphoux A, Vialou V, Drescher E et al (2006) Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology 50:941\u2013952. https:\/\/doi.org\/10.1016\/j.neuropharm.2006.01.005","journal-title":"Neuropharmacology"},{"key":"463_CR4","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1038\/jcbfm.2012.109","volume":"32","author":"P Andr\u00e9","year":"2012","unstructured":"Andr\u00e9 P, Saubam\u00e9a B, Cochois-Gu\u00e9gan V et al (2012) Transport of biogenic amine neurotransmitters at the mouse blood-retina and blood-brain barriers by uptake1 and uptake2. J Cereb Blood Flow Metab 32:1989\u20132001. https:\/\/doi.org\/10.1038\/jcbfm.2012.109","journal-title":"J Cereb Blood Flow Metab"},{"key":"463_CR5","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1124\/jpet.112.191577","volume":"341","author":"B Astorga","year":"2012","unstructured":"Astorga B, Ekins S, Morales M, Wright SH (2012) Molecular determinants of ligand selectivity for the human multidrug and toxin extruder proteins MATE1 and MATE2-K. J Pharmacol Exp Ther 341:743\u2013755. https:\/\/doi.org\/10.1124\/jpet.112.191577","journal-title":"J Pharmacol Exp Ther"},{"key":"463_CR6","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1038\/mp.2011.87","volume":"17","author":"A Bacq","year":"2012","unstructured":"Bacq A, Balasse L, Biala G et al (2012) Organic cation transporter 2 controls brain norepinephrine and serotonin clearance and antidepressant response. Mol Psychiatry 17:926\u2013939. https:\/\/doi.org\/10.1038\/mp.2011.87","journal-title":"Mol Psychiatry"},{"key":"463_CR7","doi-asserted-by":"publisher","first-page":"18976","DOI":"10.1073\/pnas.0800466105","volume":"105","author":"NL Baganz","year":"2008","unstructured":"Baganz NL, Horton RE, Calderon AS et al (2008) Organic cation transporter 3: keeping the brake on extracellular serotonin in serotonin-transporter-deficient mice. Proc Natl Acad Sci U S A 105:18976\u201318981. https:\/\/doi.org\/10.1073\/pnas.0800466105","journal-title":"Proc Natl Acad Sci U S A"},{"key":"463_CR8","doi-asserted-by":"publisher","first-page":"3873","DOI":"10.1007\/s00204-017-2008-8","volume":"91","author":"M Bai","year":"2017","unstructured":"Bai M, Ma Z, Sun D et al (2017) Multiple drug transporters mediate the placental transport of sulpiride. Arch Toxicol 91:3873\u20133884. https:\/\/doi.org\/10.1007\/s00204-017-2008-8","journal-title":"Arch Toxicol"},{"key":"463_CR9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1124\/mol.63.3.489","volume":"63","author":"D Bednarczyk","year":"2003","unstructured":"Bednarczyk D, Ekins S, Wikel JH, Wright SH (2003) Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol 63:489\u2013498. https:\/\/doi.org\/10.1124\/mol.63.3.489","journal-title":"Mol Pharmacol"},{"key":"463_CR10","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/j.1471-4159.2004.02752.x","volume":"91","author":"V Berezowski","year":"2004","unstructured":"Berezowski V, Miecz D, Marsza\u0142ek M et al (2004) Involvement of OCTN2 and B0,+ in the transport of carnitine through an in vitro model of the blood-brain barrier. J Neurochem 91:860\u2013872. https:\/\/doi.org\/10.1111\/j.1471-4159.2004.02752.x","journal-title":"J Neurochem"},{"key":"463_CR11","doi-asserted-by":"publisher","first-page":"990","DOI":"10.1124\/dmd.113.055095","volume":"42","author":"KH Boxberger","year":"2014","unstructured":"Boxberger KH, Hagenbuch B, Lampe JN (2014) Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake. Drug Metab Dispos 42:990\u2013995. https:\/\/doi.org\/10.1124\/dmd.113.055095","journal-title":"Drug Metab Dispos"},{"key":"463_CR12","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1038\/sj.bjp.0702065","volume":"125","author":"T Breidert","year":"1998","unstructured":"Breidert T, Spitzenberger F, Gr\u00fcndemann D, Sch\u00f6mig E (1998) Catecholamine transport by the organic cation transporter type 1 (OCT1). Br J Pharmacol 125:218\u2013224. https:\/\/doi.org\/10.1038\/sj.bjp.0702065","journal-title":"Br J Pharmacol"},{"key":"463_CR13","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1124\/mol.54.2.342","volume":"54","author":"AE Busch","year":"1998","unstructured":"Busch AE, Karbach U, Miska D et al (1998) Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine. Mol Pharmacol 54:342\u2013352. https:\/\/doi.org\/10.1124\/mol.54.2.342","journal-title":"Mol Pharmacol"},{"key":"463_CR14","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1002\/jcp.22054","volume":"223","author":"MM Cano","year":"2010","unstructured":"Cano MM, Calonge ML, Ilundain AA (2010) Expression of OCTN2 and OCTN3 in the apical membrane of rat renal cortex and medulla. J Cell Physiol 223:451\u2013459. https:\/\/doi.org\/10.1002\/jcp.22054","journal-title":"J Cell Physiol"},{"key":"463_CR15","doi-asserted-by":"publisher","unstructured":"Chaves C, Campanelli F, Chapy H et al (2020) An interspecies molecular and functional study of organic cation transporters at the blood-brain barrier: from rodents to humans. Pharmaceutics 12. https:\/\/doi.org\/10.3390\/pharmaceutics12040308","DOI":"10.3390\/pharmaceutics12040308"},{"key":"463_CR16","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/mp.2014.86","volume":"20","author":"T Courouss\u00e9","year":"2015","unstructured":"Courouss\u00e9 T, Bacq A, Belzung C et al (2015) Brain organic cation transporter 2 controls response and vulnerability to stress and GSK3\u03b2 signaling. Mol Psychiatry 20:889\u2013900. https:\/\/doi.org\/10.1038\/mp.2014.86","journal-title":"Mol Psychiatry"},{"key":"463_CR17","doi-asserted-by":"publisher","first-page":"8043","DOI":"10.1073\/pnas.0900358106","volume":"106","author":"M Cui","year":"2009","unstructured":"Cui M, Aras R, Christian WV et al (2009) The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway. Proc Natl Acad Sci U S A 106:8043\u20138048. https:\/\/doi.org\/10.1073\/pnas.0900358106","journal-title":"Proc Natl Acad Sci U S A"},{"key":"463_CR18","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.neuroscience.2007.01.072.EXPRESSION","volume":"146","author":"A Dahlin","year":"2007","unstructured":"Dahlin A, Xia L, Kong W et al (2007) Expression and immunolocalization of the plasma membrane monoamine transporter in the brain. Neuroscience 146:1193\u20131211. https:\/\/doi.org\/10.1016\/j.neuroscience.2007.01.072.EXPRESSION","journal-title":"Neuroscience"},{"key":"463_CR19","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1124\/jpet.110.170142","volume":"335","author":"H Duan","year":"2010","unstructured":"Duan H, Wang J (2010) Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3. J Pharmacol Exp Ther 335:743\u2013753. https:\/\/doi.org\/10.1124\/jpet.110.170142","journal-title":"J Pharmacol Exp Ther"},{"key":"463_CR20","doi-asserted-by":"publisher","first-page":"3535","DOI":"10.1074\/jbc.M112.436972","volume":"288","author":"H Duan","year":"2013","unstructured":"Duan H, Wang J (2013) Impaired monoamine and organic cation uptake in choroid plexus in mice with targeted disruption of the plasma membrane monoamine transporter (Slc29a4) gene. J Biol Chem 288:3535\u20133544. https:\/\/doi.org\/10.1074\/jbc.M112.436972","journal-title":"J Biol Chem"},{"key":"463_CR21","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1124\/mol.105.016832","volume":"68","author":"K Engel","year":"2005","unstructured":"Engel K, Wang J (2005) Interaction of organic cations with a newly identified plasma membrane monoamine transporter. Mol Pharmacol 68:1397\u20131407. https:\/\/doi.org\/10.1124\/mol.105.016832","journal-title":"Mol Pharmacol"},{"key":"463_CR22","doi-asserted-by":"publisher","first-page":"50042","DOI":"10.1074\/jbc.M407913200","volume":"279","author":"K Engel","year":"2004","unstructured":"Engel K, Zhou M, Wang J (2004) Identification and characterization of a novel monoamine transporter in the human brain. J Biol Chem 279:50042\u201350049. https:\/\/doi.org\/10.1074\/jbc.M407913200","journal-title":"J Biol Chem"},{"key":"463_CR23","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.2174\/13816128113199990456","volume":"20","author":"CA Farthing","year":"2014","unstructured":"Farthing CA, Sweet DH (2014) Expression and function of organic cation and anion transporters (SLC22 family) in the CNS. Curr Pharm Des 20:1472\u20131486. https:\/\/doi.org\/10.2174\/13816128113199990456","journal-title":"Curr Pharm Des"},{"key":"463_CR24","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.brainres.2005.09.016","volume":"1063","author":"N Feng","year":"2005","unstructured":"Feng N, Mo B, Johnson PL et al (2005) Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus. Brain Res 1063:69\u201376. https:\/\/doi.org\/10.1016\/j.brainres.2005.09.016","journal-title":"Brain Res"},{"key":"463_CR25","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.yhbeh.2009.03.023","volume":"56","author":"N Feng","year":"2009","unstructured":"Feng N, Telefont M, Kelly KJ et al (2009) Local perfusion of corticosterone in the rat medial hypothalamus potentiates d-fenfluramine-induced elevations of extracellular 5-HT concentrations. Horm Behav 56:149\u2013157. https:\/\/doi.org\/10.1016\/j.yhbeh.2009.03.023","journal-title":"Horm Behav"},{"key":"463_CR26","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.phrs.2018.11.013","volume":"140","author":"VR Garbarino","year":"2019","unstructured":"Garbarino VR, Santos TA, Nelson AR et al (2019) Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice. Pharmacol Res 140:21\u201332. https:\/\/doi.org\/10.1016\/j.phrs.2018.11.013","journal-title":"Pharmacol Res"},{"key":"463_CR27","doi-asserted-by":"publisher","first-page":"8758","DOI":"10.1523\/JNEUROSCI.0570-06.2006","volume":"26","author":"PJ Gasser","year":"2006","unstructured":"Gasser PJ, Lowry CA, Orchinik M (2006) Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci 26:8758\u20138766. https:\/\/doi.org\/10.1523\/JNEUROSCI.0570-06.2006","journal-title":"J Neurosci"},{"key":"463_CR28","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1002\/cne.21921","volume":"512","author":"PJ Gasser","year":"2009","unstructured":"Gasser PJ, Orchinik M, Raju I, Lowry CA (2009) Distribution of organic cation transporter 3, a corticosterone-sensitive monoamine transporter, in the rat brain. J Comp Neurol 512:529\u2013555. https:\/\/doi.org\/10.1002\/cne.21921","journal-title":"J Comp Neurol"},{"key":"463_CR29","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1007\/s00429-016-1315-9.Organic","volume":"222","author":"PJ Gasser","year":"2017","unstructured":"Gasser PJ, Hurley MM, Chan J, Pickel VM (2017) Organic cation transporter 3 (OCT3) is localized to intracellular and surface membranes in select glial and neuronal cells within the basolateral amygdaloid complex of both rats and mice. Brain Struct Funct 222:1913\u20131928. https:\/\/doi.org\/10.1007\/s00429-016-1315-9.Organic","journal-title":"Brain Struct Funct"},{"key":"463_CR30","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/clpt.2013.175","volume":"94","author":"EG Geier","year":"2013","unstructured":"Geier EG, Chen EC, Webb A et al (2013) Profiling solute carrier transporters in the human blood-brain barrier. Clin Pharmacol Ther 94:636\u2013639. https:\/\/doi.org\/10.1038\/clpt.2013.175","journal-title":"Clin Pharmacol Ther"},{"key":"463_CR31","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.nbd.2005.08.002","volume":"21","author":"A Gerhard","year":"2006","unstructured":"Gerhard A, Pavese N, Hotton G et al (2006) In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson\u2019s disease. Neurobiol Dis 21:404\u2013412. https:\/\/doi.org\/10.1016\/j.nbd.2005.08.002","journal-title":"Neurobiol Dis"},{"key":"463_CR32","doi-asserted-by":"publisher","first-page":"1706","DOI":"10.1111\/ejn.13968","volume":"48","author":"TL Gilman","year":"2018","unstructured":"Gilman TL, George CM, Vitela M et al (2018) Constitutive plasma membrane monoamine transporter (PMAT, Slc29a4) deficiency subtly affects anxiety-like and coping behaviours. Eur J Neurosci 48:1706\u20131716. https:\/\/doi.org\/10.1111\/ejn.13968","journal-title":"Eur J Neurosci"},{"key":"463_CR33","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1089\/dna.1997.16.871","volume":"16","author":"V Gorboulev","year":"1997","unstructured":"Gorboulev V, Ulzheimer JC, Akhoundova A et al (1997) Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol 16:871\u2013881. https:\/\/doi.org\/10.1089\/dna.1997.16.871","journal-title":"DNA Cell Biol"},{"key":"463_CR34","doi-asserted-by":"publisher","first-page":"1556","DOI":"10.1002\/hep.510290530","volume":"29","author":"R Green","year":"1999","unstructured":"Green R, Lo K, Sterritt C, Beier D (1999) Cloning and functional expression of a mouse liver organic cation transporter. Hepatology 29:1556\u20131562","journal-title":"Hepatology"},{"key":"463_CR35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/372549a0","volume":"372","author":"D Grundemann","year":"1994","unstructured":"Grundemann D, Gorboulev V, Gambaryan S et al (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549\u2013552","journal-title":"Nature"},{"key":"463_CR36","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/372549a0","volume":"372","author":"D Gr\u00fcndemann","year":"1994","unstructured":"Gr\u00fcndemann D, Gorboulev V, Gambaryan S et al (1994) Drug excretion mediated by a new prototype of polyspecific transporter. Nature 372:549\u2013552","journal-title":"Nature"},{"key":"463_CR37","doi-asserted-by":"publisher","first-page":"10408","DOI":"10.1074\/jbc.272.16.10408","volume":"272","author":"D Gr\u00fcndemann","year":"1997","unstructured":"Gr\u00fcndemann D, Babin-Ebell J, Martel F et al (1997) Primary structure and functional expression of the apical organic cation transporter from kidney epithelial LLC-PK1 cells. J Biol Chem 272:10408\u201310413. https:\/\/doi.org\/10.1074\/jbc.272.16.10408","journal-title":"J Biol Chem"},{"key":"463_CR38","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/1557","volume":"1","author":"D Grundemann","year":"1998","unstructured":"Grundemann D, Schechinger B, Rappold GA, Schomig E (1998) Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1:349\u2013351. https:\/\/doi.org\/10.1038\/1557","journal-title":"Nat Neurosci"},{"key":"463_CR39","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/1557","volume":"1","author":"D Gr\u00fcndemann","year":"1998","unstructured":"Gr\u00fcndemann D, Schechinger B, Rappold GA, Sch\u00f6mig E (1998) Molecular identification of the corticosterone-sensitive extraneuronal catecholamine transporter. Nat Neurosci 1:349\u2013351. https:\/\/doi.org\/10.1038\/1557","journal-title":"Nat Neurosci"},{"key":"463_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/mol.56.1.1","volume":"56","author":"D Gr\u00fcndemann","year":"1999","unstructured":"Gr\u00fcndemann D, Liebich G, Kiefer N et al (1999) Selective substrates for non-neuronal monoamine transporters. Mol Pharmacol 56:1\u201310. https:\/\/doi.org\/10.1124\/mol.56.1.1","journal-title":"Mol Pharmacol"},{"key":"463_CR41","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1007\/s00210-009-0479-8","volume":"381","author":"B Haenisch","year":"2010","unstructured":"Haenisch B, B\u00f6nisch H (2010) Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics. Naunyn Schmiedeberg\u2019s Arch Pharmacol 381:33\u201339. https:\/\/doi.org\/10.1007\/s00210-009-0479-8","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"463_CR42","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s00210-012-0781-8","volume":"385","author":"B Haenisch","year":"2012","unstructured":"Haenisch B, Drescher E, Thiemer L et al (2012) Interaction of antidepressant and antipsychotic drugs with the human organic cation transporters hOCT1, hOCT2 and hOCT3. Naunyn Schmiedeberg\u2019s Arch Pharmacol 385:1017\u20131023. https:\/\/doi.org\/10.1007\/s00210-012-0781-8","journal-title":"Naunyn Schmiedeberg\u2019s Arch Pharmacol"},{"key":"463_CR43","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1002\/glia.23153","volume":"65","author":"Q He","year":"2017","unstructured":"He Q, Wang Q, Yuan C, Wang Y (2017) Downregulation of miR-7116-5p in microglia by MPP+ sensitizes TNF-\u03b1 production to induce dopaminergic neuron damage. Glia 65:1251\u20131263. https:\/\/doi.org\/10.1002\/glia.23153","journal-title":"Glia"},{"key":"463_CR44","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jchemneu.2013.04.007","volume":"52","author":"JE Hill","year":"2013","unstructured":"Hill JE, Gasser PJ (2013) Organic cation transporter 3 is densely expressed in the intercalated cell groups of the amygdala: anatomical evidence for a stress hormone-sensitive dopamine clearance system. J Chem Neuroanat 52:36\u201343. https:\/\/doi.org\/10.1016\/j.jchemneu.2013.04.007","journal-title":"J Chem Neuroanat"},{"key":"463_CR45","doi-asserted-by":"publisher","first-page":"4546","DOI":"10.1111\/ejn.14927","volume":"52","author":"KM Holleran","year":"2020","unstructured":"Holleran KM, Rose JH, Fordahl SC et al (2020) Organic cation transporter 3 and the dopamine transporter differentially regulate catecholamine uptake in the basolateral amygdala and nucleus accumbens. Eur J Neurosci 52:4546\u20134562. https:\/\/doi.org\/10.1111\/ejn.14927","journal-title":"Eur J Neurosci"},{"key":"463_CR46","doi-asserted-by":"publisher","first-page":"4601","DOI":"10.1172\/JCI136796","volume":"130","author":"KM Huang","year":"2020","unstructured":"Huang KM, Leblanc AF, Uddin ME et al (2020) Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice. J Clin Invest 130:4601\u20134606. https:\/\/doi.org\/10.1172\/JCI136796","journal-title":"J Clin Invest"},{"key":"463_CR47","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1046\/j.1471-4159.2003.01566.x","volume":"84","author":"M Inazu","year":"2003","unstructured":"Inazu M, Takeda H, Matsumiya T (2003) Expression and functional characterization of the extraneuronal monoamine transporter in normal human astrocytes. J Neurochem 84:43\u201352. https:\/\/doi.org\/10.1046\/j.1471-4159.2003.01566.x","journal-title":"J Neurochem"},{"key":"463_CR48","doi-asserted-by":"publisher","first-page":"1427","DOI":"10.1111\/j.1471-4159.2005.03299.x","volume":"94","author":"M Inazu","year":"2005","unstructured":"Inazu M, Takeda H, Matsumiya T (2005) Molecular and functional characterization of an Na+-independent choline transporter in rat astrocytes. J Neurochem 94:1427\u20131437. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03299.x","journal-title":"J Neurochem"},{"key":"463_CR49","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1111\/j.1471-4159.2006.03757.x","volume":"97","author":"M Inazu","year":"2006","unstructured":"Inazu M, Takeda H, Maehara K et al (2006) Functional expression of the organic cation\/carnitine transporter 2 in rat astrocytes. J Neurochem 97:424\u2013434. https:\/\/doi.org\/10.1111\/j.1471-4159.2006.03757.x","journal-title":"J Neurochem"},{"key":"463_CR50","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1007\/s11064-017-2350-5","volume":"43","author":"T Ishimoto","year":"2018","unstructured":"Ishimoto T, Nakamichi N, Nishijima H et al (2018) Carnitine\/organic cation transporter OCTN1 negatively regulates activation in murine cultured microglial cells. Neurochem Res 43:107\u2013119. https:\/\/doi.org\/10.1007\/s11064-017-2350-5","journal-title":"Neurochem Res"},{"key":"463_CR51","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1007\/s00213-019-05203-5","volume":"236","author":"KA Iyer","year":"2019","unstructured":"Iyer KA, Alix K, Eltit JM et al (2019) Multi-modal antidepressant-like action of 6- and 7-chloro-2-aminodihydroquinazolines in the mouse tail suspension test. Psychopharmacology 236:2093\u20132104. https:\/\/doi.org\/10.1007\/s00213-019-05203-5","journal-title":"Psychopharmacology"},{"key":"463_CR52","doi-asserted-by":"publisher","first-page":"2599","DOI":"10.1016\/j.biocel.2009.08.020","volume":"41","author":"E Januszewicz","year":"2009","unstructured":"Januszewicz E, Pajak B, Gajkowska B et al (2009) Organic cation\/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist. Int J Biochem Cell Biol 41:2599\u20132609. https:\/\/doi.org\/10.1016\/j.biocel.2009.08.020","journal-title":"Int J Biochem Cell Biol"},{"key":"463_CR53","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1007\/s11064-010-0131-5","volume":"35","author":"E Januszewicz","year":"2010","unstructured":"Januszewicz E, Bekisz M, Mozrzymas JW, Na\u0142ecz KA (2010) High affinity carnitine transporters from OCTN family in neural cells. Neurochem Res 35:743\u2013748. https:\/\/doi.org\/10.1007\/s11064-010-0131-5","journal-title":"Neurochem Res"},{"key":"463_CR54","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1007\/s11095-010-0076-z","volume":"27","author":"Y Kato","year":"2010","unstructured":"Kato Y, Kubo Y, Iwata D et al (2010) Gene knockout and metabolome analysis of carnitine\/organic cation transporter OCTN1. Pharm Res 27:832\u2013840. https:\/\/doi.org\/10.1007\/s11095-010-0076-z","journal-title":"Pharm Res"},{"key":"463_CR55","doi-asserted-by":"publisher","first-page":"15971","DOI":"10.1074\/jbc.273.26.15971","volume":"273","author":"R Kekuda","year":"1998","unstructured":"Kekuda R, Prasad PD, Wu X et al (1998) Cloning and functional characterization of a potential-sensitive, polyspecific organic cation transporter (OCT3) most abundantly expressed in placenta. J Biol Chem 273:15971\u201315979","journal-title":"J Biol Chem"},{"key":"463_CR56","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1046\/j.1471-4159.2001.00621.x","volume":"79","author":"Y Kido","year":"2001","unstructured":"Kido Y, Tamai I, Ohnari A et al (2001) Functional relevance of carnitine transporter OCTN2 to brain distribution of L-camitine and acetyl-L-carnitine across the blood-brain barrier. J Neurochem 79:959\u2013969. https:\/\/doi.org\/10.1046\/j.1471-4159.2001.00621.x","journal-title":"J Neurochem"},{"key":"463_CR57","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.neulet.2005.03.014","volume":"382","author":"K Kitaichi","year":"2005","unstructured":"Kitaichi K, Fukuda M, Nakayama H et al (2005) Behavioral changes following antisense oligonucleotide-induced reduction of organic cation transporter-3 in mice. Neurosci Lett 382:195\u2013200. https:\/\/doi.org\/10.1016\/j.neulet.2005.03.014","journal-title":"Neurosci Lett"},{"key":"463_CR58","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1146\/annurev.physiol.60.1.243","volume":"60","author":"H Koepsell","year":"1998","unstructured":"Koepsell H (1998) Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol 60:243\u2013266. https:\/\/doi.org\/10.1146\/annurev.physiol.60.1.243","journal-title":"Annu Rev Physiol"},{"key":"463_CR59","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1124\/pr.118.015578","volume":"72","author":"H Koepsell","year":"2020","unstructured":"Koepsell H (2020) Organic cation transporters in health and disease. Pharmacol Rev 72:253\u2013319. https:\/\/doi.org\/10.1124\/pr.118.015578","journal-title":"Pharmacol Rev"},{"key":"463_CR60","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1258\/002367788780746511","volume":"22","author":"T Koizumi","year":"1988","unstructured":"Koizumi T, Nikaidoi H, Nonomura A, Yoneda T (1988) Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2\u00b0 strain of mouse with similarities to Reye\u2019s syndrome. Lab Anim 22:83\u201387. https:\/\/doi.org\/10.1258\/002367788780746511","journal-title":"Lab Anim"},{"key":"463_CR61","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1124\/pr.108.000869","volume":"63","author":"A Kristensen","year":"2011","unstructured":"Kristensen A, Andersen J, Jorgensen T et al (2011) SLC6 neurotransmitter transporters: structure, function, and regulation. Pharmacol Rev 63:585\u2013640","journal-title":"Pharmacol Rev"},{"key":"463_CR62","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S0006-291X(02)02946-7","volume":"301","author":"AM Lamhonwah","year":"2003","unstructured":"Lamhonwah AM, Skaug J, Scherer SW, Tein I (2003) A third human carnitine\/organic cation transporter (OCTN3) as a candidate for the 5q31 Crohn\u2019s disease locus (IBD5). Biochem Biophys Res Commun 301:98\u2013101. https:\/\/doi.org\/10.1016\/S0006-291X(02)02946-7","journal-title":"Biochem Biophys Res Commun"},{"key":"463_CR63","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1016\/j.bbrc.2005.10.170","volume":"338","author":"AM Lamhonwah","year":"2005","unstructured":"Lamhonwah AM, Ackerley CA, Tilups A et al (2005) OCTN3 is a mammalian peroxisomal membrane carnitine transporter. Biochem Biophys Res Commun 338:1966\u20131972. https:\/\/doi.org\/10.1016\/j.bbrc.2005.10.170","journal-title":"Biochem Biophys Res Commun"},{"key":"463_CR64","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.braindev.2007.05.005","volume":"30","author":"AM Lamhonwah","year":"2008","unstructured":"Lamhonwah AM, Hawkins CE, Tam C et al (2008) Expression patterns of the organic cation\/carnitine transporter family in adult murine brain. Brain and Development 30:31\u201342. https:\/\/doi.org\/10.1016\/j.braindev.2007.05.005","journal-title":"Brain and Development"},{"issue":"FEB","key":"463_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fphar.2013.00014","volume":"4","author":"RWS Li","year":"2013","unstructured":"Li RWS, Yang C, Kwan YW et al (2013) Involvement of organic cation transporter-3 and plasma membrane monoamine transporter in serotonin uptake in human brain vascular smooth muscle cells. Front Pharmacol 4(FEB):1\u20138. https:\/\/doi.org\/10.3389\/fphar.2013.00014","journal-title":"Front Pharmacol"},{"key":"463_CR66","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1002\/bdd.2104","volume":"38","author":"L Li","year":"2017","unstructured":"Li L, Weng Y, Wang W et al (2017) Multiple organic cation transporters contribute to the renal transport of sulpiride. Biopharm Drug Dispos 38:526\u2013534. https:\/\/doi.org\/10.1002\/bdd.2104","journal-title":"Biopharm Drug Dispos"},{"key":"463_CR67","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1471-4159.2010.06801.x","volume":"114","author":"C-J Lin","year":"2010","unstructured":"Lin C-J, Tai Y, Huang M-T et al (2010) Cellular localization of the organic cation transporters, OCT1 and OCT2, in brain microvessel endothelial cells and its implication for MPTP transport across the blood-brain barrier and MPTP-induced dopaminergic toxicity in rodents. J Neurochem 114:717\u2013727. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.06801.x","journal-title":"J Neurochem"},{"key":"463_CR68","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1165\/rcmb.2004-0363OC","volume":"33","author":"KS Lips","year":"2005","unstructured":"Lips KS, Volk C, Schmitt BM et al (2005) Polyspecific cation transporters mediate luminal release of acetylcholine from bronchial epithelium. Am J Respir Cell Mol Biol 33:79\u201388. https:\/\/doi.org\/10.1165\/rcmb.2004-0363OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"463_CR69","doi-asserted-by":"publisher","first-page":"590","DOI":"10.1006\/bbrc.1998.9708","volume":"252","author":"KM Lu","year":"1998","unstructured":"Lu KM, Nishimori H, Nakamura Y et al (1998) A missense mutation of mouse OCTN2, a sodium-dependent carnitine cotransporter, in the juvenile visceral steatosis mouse. Biochem Biophys Res Commun 252:590\u2013594. https:\/\/doi.org\/10.1006\/bbrc.1998.9708","journal-title":"Biochem Biophys Res Commun"},{"key":"463_CR70","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.pbb.2015.01.004","volume":"131","author":"CA Marcinkiewcz","year":"2015","unstructured":"Marcinkiewcz CA, Devine DP (2015) Modulation of OCT3 expression by stress, and antidepressant-like activity of decynium-22 in an animal model of depression. Pharmacol Biochem Behav 131:33\u201341. https:\/\/doi.org\/10.1016\/j.pbb.2015.01.004","journal-title":"Pharmacol Biochem Behav"},{"key":"463_CR71","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00424-013-1335-8","volume":"466","author":"V Massmann","year":"2014","unstructured":"Massmann V, Edemir B, Schlatter E et al (2014) The organic cation transporter 3 (OCT3) as molecular target of psychotropic drugs: transport characteristics and acute regulation of cloned murine OCT3. Pflugers Arch Eur J Physiol 466:517\u2013527. https:\/\/doi.org\/10.1007\/s00424-013-1335-8","journal-title":"Pflugers Arch Eur J Physiol"},{"key":"463_CR72","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1681\/ASN.2006030205","volume":"17","author":"S Masuda","year":"2006","unstructured":"Masuda S, Terada T, Yonezawa A et al (2006) Identification and functional characterization of a new human kidney-specific H+\/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol 17:2127\u20132135. https:\/\/doi.org\/10.1681\/ASN.2006030205","journal-title":"J Am Soc Nephrol"},{"key":"463_CR73","doi-asserted-by":"publisher","first-page":"2408","DOI":"10.1038\/s41386-018-0053-5","volume":"43","author":"FP Mayer","year":"2018","unstructured":"Mayer FP, Schmid D, Owens WA et al (2018) An unsuspected role for organic cation transporter 3 in the actions of amphetamine. Neuropsychopharmacology 43:2408\u20132417. https:\/\/doi.org\/10.1038\/s41386-018-0053-5","journal-title":"Neuropsychopharmacology"},{"key":"463_CR74","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1471-4159.2007.05024.x","volume":"104","author":"D Miecz","year":"2008","unstructured":"Miecz D, Januszewicz E, Czeredys M et al (2008) Localization of organic cation\/carnitine transporter (OCTN2) in cells forming the blood-brain barrier. J Neurochem 104:113\u2013123. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.05024.x","journal-title":"J Neurochem"},{"key":"463_CR75","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1002\/2211-5463.12183","volume":"7","author":"Y Miura","year":"2017","unstructured":"Miura Y, Yoshikawa T, Naganuma F et al (2017) Characterization of murine polyspecific monoamine transporters. FEBS Open Bio 7:237\u2013248. https:\/\/doi.org\/10.1002\/2211-5463.12183","journal-title":"FEBS Open Bio"},{"key":"463_CR76","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1016\/j.bbrc.2004.08.112","volume":"323","author":"J Monte","year":"2004","unstructured":"Monte J, Nagle M, Eraly S, Nigam S (2004) Identification of a novel murine organic anion transporter family member, OAT6, expressed in olfactory mucosa. Biochem Biophys Res Commun 323:429\u2013436","journal-title":"Biochem Biophys Res Commun"},{"key":"463_CR77","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1007\/s003359900976","volume":"10","author":"KA Mooslehner","year":"1999","unstructured":"Mooslehner KA, Allen ND (1999) Cloning of the mouse organic cation transporter 2 gene, Slc22a2, from an enhancer-trap transgene integration locus. Mamm Genome 10:218\u2013224. https:\/\/doi.org\/10.1007\/s003359900976","journal-title":"Mamm Genome"},{"key":"463_CR78","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1016\/j.neuint.2012.08.004","volume":"61","author":"N Nakamichi","year":"2012","unstructured":"Nakamichi N, Taguchi T, Hosotani H et al (2012) Functional expression of carnitine\/organic cation transporter OCTN1 in mouse brain neurons: possible involvement in neuronal differentiation. Neurochem Int 61:1121\u20131132. https:\/\/doi.org\/10.1016\/j.neuint.2012.08.004","journal-title":"Neurochem Int"},{"key":"463_CR79","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1016\/j.brainres.2007.09.072","volume":"1184","author":"H Nakayama","year":"2007","unstructured":"Nakayama H, Kitaichi K, Ito Y et al (2007) The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res 1184:260\u2013269. https:\/\/doi.org\/10.1016\/j.brainres.2007.09.072","journal-title":"Brain Res"},{"key":"463_CR80","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s00210-007-0219-x","volume":"376","author":"AT Nies","year":"2008","unstructured":"Nies AT, Herrmann E, Brom M, Keppler D (2008) Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1). Naunyn Schmiedeberg's Arch Pharmacol 376:449\u2013461. https:\/\/doi.org\/10.1007\/s00210-007-0219-x","journal-title":"Naunyn Schmiedeberg's Arch Pharmacol"},{"key":"463_CR81","doi-asserted-by":"publisher","first-page":"2005","DOI":"10.1124\/dmd.108.022087","volume":"36","author":"T Okura","year":"2008","unstructured":"Okura T, Hattori A, Takano Y et al (2008) Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone. Drug Metab Dispos 36:2005\u20132013. https:\/\/doi.org\/10.1124\/dmd.108.022087","journal-title":"Drug Metab Dispos"},{"key":"463_CR82","doi-asserted-by":"publisher","first-page":"3924","DOI":"10.1002\/jps.22594","volume":"100","author":"T Okura","year":"2011","unstructured":"Okura T, Kato S, Takano Y et al (2011) Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers. J Pharm Sci 100:3924\u20133938. https:\/\/doi.org\/10.1002\/jps.22594","journal-title":"J Pharm Sci"},{"key":"463_CR83","doi-asserted-by":"publisher","first-page":"17923","DOI":"10.1073\/pnas.0506483102","volume":"102","author":"M Otsuka","year":"2005","unstructured":"Otsuka M, Matsumoto T, Morimoto R et al (2005) A human transporter protein that mediates the final excretion step for toxic organic cations. Proc Natl Acad Sci U S A 102:17923\u201317928. https:\/\/doi.org\/10.1073\/pnas.0506483102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"463_CR84","doi-asserted-by":"publisher","first-page":"4440","DOI":"10.1016\/j.bmcl.2017.08.008","volume":"27","author":"X Pan","year":"2017","unstructured":"Pan X, Iyer KA, Sweet DH et al (2017) A new chemotype inhibitor for the human organic cation transporter 3 (hOCT3). Bioorg Med Chem Lett 27:4440\u20134445. https:\/\/doi.org\/10.1016\/j.bmcl.2017.08.008","journal-title":"Bioorg Med Chem Lett"},{"key":"463_CR85","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.1208\/s12248-014-9649-9","volume":"16","author":"JNDS Pereira","year":"2014","unstructured":"Pereira JNDS, Tadjerpisheh S, Abed MA et al (2014) The poorly membrane permeable antipsychotic drugs amisulpride and sulpiride are substrates of the organic cation transporters from the slc22 family. AAPS J 16:1247\u20131256. https:\/\/doi.org\/10.1208\/s12248-014-9649-9","journal-title":"AAPS J"},{"key":"463_CR86","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/j.bbamem.2011.12.014","volume":"1818","author":"L Pochini","year":"2012","unstructured":"Pochini L, Scalise M, Galluccio M et al (2012) The human OCTN1 (SLC22A4) reconstituted in liposomes catalyzes acetylcholine transport which is defective in the mutant L503F associated to the Crohn\u2019s disease. Biochim Biophys Acta Biomembr 1818:559\u2013565. https:\/\/doi.org\/10.1016\/j.bbamem.2011.12.014","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"463_CR87","doi-asserted-by":"publisher","first-page":"1256","DOI":"10.1111\/j.1460-9568.1996.tb01294.x","volume":"8","author":"H Russ","year":"1996","unstructured":"Russ H, Staudt K, Martel F et al (1996) The extraneuronal transporter for monoamine transmitters exists in cells derived from human central nervous system glia. Eur J Neurosci 8:1256\u20131264","journal-title":"Eur J Neurosci"},{"key":"463_CR88","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1124\/mol.117.111443","volume":"94","author":"PJ Sandoval","year":"2018","unstructured":"Sandoval PJ, Zorn KM, Clark AM et al (2018) Assessment of substrate-dependent ligand interactions at the organic cation transporter OCT2 using six model substrates s. Mol Pharmacol 94:1057\u20131068. https:\/\/doi.org\/10.1124\/mol.117.111443","journal-title":"Mol Pharmacol"},{"key":"463_CR89","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1002\/jnr.10521","volume":"71","author":"A Schmitt","year":"2003","unstructured":"Schmitt A, Mossner R, Gossmann A et al (2003) Organic cation transporter capable of transporting serotonin is up-regulated in serotonin transporter-deficient mice. J Neurosci Res 71:701\u2013709. https:\/\/doi.org\/10.1002\/jnr.10521","journal-title":"J Neurosci Res"},{"key":"463_CR90","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/bdd.2112","volume":"39","author":"R Shi","year":"2018","unstructured":"Shi R, Yang Y, Xu Z et al (2018) Renal vectorial transport of berberine mediated by organic cation transporter 2 (OCT2) and multidrug and toxin extrusion proteins 1 (MATE1) in rats. Biopharm Drug Dispos 39:47\u201358. https:\/\/doi.org\/10.1002\/bdd.2112","journal-title":"Biopharm Drug Dispos"},{"key":"463_CR91","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/j.ejps.2018.11.010","volume":"127","author":"R Shi","year":"2019","unstructured":"Shi R, Xu Z, Xu X et al (2019) Organic cation transporter and multidrug and toxin extrusion 1 co-mediated interaction between metformin and berberine. Eur J Pharm Sci 127:282\u2013290. https:\/\/doi.org\/10.1016\/j.ejps.2018.11.010","journal-title":"Eur J Pharm Sci"},{"key":"463_CR92","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jchemneu.2016.09.006","volume":"83\u201384","author":"Y Shirasaka","year":"2017","unstructured":"Shirasaka Y, Lee N, Duan H et al (2017) Interspecies comparison of the functional characteristics of plasma membrane monoamine transporter (PMAT) between human, rat and mouse. J Chem Neuroanat 83\u201384:99\u2013106. https:\/\/doi.org\/10.1016\/j.jchemneu.2016.09.006","journal-title":"J Chem Neuroanat"},{"key":"463_CR93","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuron.2006.01.022","volume":"49","author":"AR Simard","year":"2006","unstructured":"Simard AR, Soulet D, Gowing G et al (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer\u2019s disease. Neuron 49:489\u2013502. https:\/\/doi.org\/10.1016\/j.neuron.2006.01.022","journal-title":"Neuron"},{"key":"463_CR94","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1124\/dmd.30.2.212","volume":"30","author":"AL Slitt","year":"2002","unstructured":"Slitt AL, Cherrington NJ, Hartley DP et al (2002) Tissue distribution and renal developmental changes in rat organic cation transporter mRNA levels. Drug Metab Dispos 30:212\u2013219. https:\/\/doi.org\/10.1124\/dmd.30.2.212","journal-title":"Drug Metab Dispos"},{"key":"463_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pbio.2006571","volume":"17","author":"W Song","year":"2019","unstructured":"Song W, Luo Q, Zhang Y et al (2019) Organic cation transporter 3 (Oct3) is a distinct catecholamines clearance route in adipocytes mediating the beiging of white adipose tissue. PLoS Biol 17:1\u201328. https:\/\/doi.org\/10.1371\/journal.pbio.2006571","journal-title":"PLoS Biol"},{"key":"463_CR96","doi-asserted-by":"publisher","first-page":"11199","DOI":"10.1073\/pnas.1305321110","volume":"110","author":"JA Sprowl","year":"2013","unstructured":"Sprowl JA, Ciarimboli G, Lancaster CS et al (2013) Oxaliplatin-induced neurotoxicity is dependent on the organic cation transporter OCT2. Proc Natl Acad Sci U S A 110:11199\u201311204. https:\/\/doi.org\/10.1073\/pnas.1305321110","journal-title":"Proc Natl Acad Sci U S A"},{"key":"463_CR97","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1124\/mol.104.004713","volume":"67","author":"WM Suhre","year":"2005","unstructured":"Suhre WM, Ekins S, Chang C et al (2005) Molecular determinants of substrate\/inhibitor binding to the human and rabbit renal organic cation transporters hOCT2 and rbOCT2. Mol Pharmacol 67:1067\u20131077. https:\/\/doi.org\/10.1124\/mol.104.004713","journal-title":"Mol Pharmacol"},{"key":"463_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pnpbp.2013.11.005","volume":"49","author":"S Sun","year":"2014","unstructured":"Sun S, Wang K, Lei H et al (2014) Inhibition of organic cation transporter 2 and 3 may be involved in the mechanism of the antidepressant-like action of berberine. Prog Neuro-Psychopharmacol Biol Psychiatry 49:1\u20136. https:\/\/doi.org\/10.1016\/j.pnpbp.2013.11.005","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"463_CR99","doi-asserted-by":"publisher","first-page":"F890","DOI":"10.1152\/ajprenal.1999.277.6.f890","volume":"277","author":"DH Sweet","year":"1999","unstructured":"Sweet DH, Pritchard JB (1999) rOCT2 is a basolateral potential-driven carrier, not an organic cation\/proton exchanger. Am J Physiol Ren Physiol 277:F890\u2013F898. https:\/\/doi.org\/10.1152\/ajprenal.1999.277.6.f890","journal-title":"Am J Physiol Ren Physiol"},{"key":"463_CR100","doi-asserted-by":"publisher","first-page":"41611","DOI":"10.1074\/jbc.M108472200","volume":"276","author":"DH Sweet","year":"2001","unstructured":"Sweet DH, Miller DS, Pritchard JB (2001) Ventricular choline transport: a role for organic cation transporter 2 expressed in choroid plexus. J Biol Chem 276:41611\u201341619. https:\/\/doi.org\/10.1074\/jbc.M108472200","journal-title":"J Biol Chem"},{"key":"463_CR101","doi-asserted-by":"publisher","first-page":"2558","DOI":"10.1016\/j.xphs.2017.05.006","volume":"106","author":"H Takano","year":"2017","unstructured":"Takano H, Ito S, Zhang X et al (2017) Possible role of organic cation transporters in the distribution of [11C] sulpiride, a dopamine D2 receptor antagonist. J Pharm Sci 106:2558\u20132565. https:\/\/doi.org\/10.1016\/j.xphs.2017.05.006","journal-title":"J Pharm Sci"},{"key":"463_CR102","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0014-5793(97)01441-5","volume":"419","author":"I Tamai","year":"1997","unstructured":"Tamai I, Yabuuchi H, Nezu JI et al (1997) Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. FEBS Lett 419:107\u2013111. https:\/\/doi.org\/10.1016\/S0014-5793(97)01441-5","journal-title":"FEBS Lett"},{"key":"463_CR103","doi-asserted-by":"publisher","first-page":"20378","DOI":"10.1074\/jbc.273.32.20378","volume":"273","author":"I Tamai","year":"1998","unstructured":"Tamai I, Ohashi R, Nezu JI et al (1998) Molecular and functional identification of sodium ion-dependent, high affinity human carnitine transporter OCTN2. J Biol Chem 273:20378\u201320382. https:\/\/doi.org\/10.1074\/jbc.273.32.20378","journal-title":"J Biol Chem"},{"key":"463_CR104","doi-asserted-by":"publisher","first-page":"40064","DOI":"10.1074\/jbc.M005340200","volume":"275","author":"I Tamai","year":"2000","unstructured":"Tamai I, Ohashi R, Nezu JI et al (2000) Molecular and functional characterization of organic cation\/carnitine transporter family in mice. J Biol Chem 275:40064\u201340072. https:\/\/doi.org\/10.1074\/jbc.M005340200","journal-title":"J Biol Chem"},{"key":"463_CR105","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1021\/mp0340082","volume":"1","author":"I Tamai","year":"2004","unstructured":"Tamai I, Nakanishi T, Kobayashi D et al (2004) Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations. Mol Pharm 1:57\u201366. https:\/\/doi.org\/10.1021\/mp0340082","journal-title":"Mol Pharm"},{"key":"463_CR106","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.1007\/s11095-006-9016-3","volume":"23","author":"T Terada","year":"2006","unstructured":"Terada T, Masuda S, Asaka JI et al (2006) Molecular cloning, functional characterization and tissue distribution of rat H+\/organic cation antiporter MATE1. Pharm Res 23:1696\u20131701. https:\/\/doi.org\/10.1007\/s11095-006-9016-3","journal-title":"Pharm Res"},{"key":"463_CR107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0005-2736(97)00207-1","volume":"1369","author":"S Terashita","year":"1998","unstructured":"Terashita S, Dresser MJ, Zhang L et al (1998) Molecular cloning and functional expression of a rabbit renal organic cation transporter. Biochim Biophys Acta Biomembr 1369:1\u20136. https:\/\/doi.org\/10.1016\/S0005-2736(97)00207-1","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"463_CR108","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1152\/ajprenal.00312.2006","volume":"292","author":"M Tsuda","year":"2007","unstructured":"Tsuda M, Terada T, Asaka JI et al (2007) Oppositely directed H+ gradient functions as a driving force of rat H+\/organic cation antiporter MATE1. Am J Physiol Ren Physiol 292:593\u2013598. https:\/\/doi.org\/10.1152\/ajprenal.00312.2006","journal-title":"Am J Physiol Ren Physiol"},{"key":"463_CR109","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.bcp.2013.06.019","volume":"86","author":"MV Tzvetkov","year":"2013","unstructured":"Tzvetkov MV, dos Santos Pereira JN, Meineke I et al (2013) Morphine is a substrate of the organic cation transporter OCT1 and polymorphisms in OCT1 gene affect morphine pharmacokinetics after codeine administration. Biochem Pharmacol 86:666\u2013678. https:\/\/doi.org\/10.1016\/j.bcp.2013.06.019","journal-title":"Biochem Pharmacol"},{"key":"463_CR110","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1111\/jnc.13147","volume":"134","author":"Y Uchida","year":"2015","unstructured":"Uchida Y, Zhang Z, Tachikawa M, Terasaki T (2015) Quantitative targeted absolute proteomics of rat blood-cerebrospinal fluid barrier transporters: comparison with a human specimen. J Neurochem 134:1104\u20131115. https:\/\/doi.org\/10.1111\/jnc.13147","journal-title":"J Neurochem"},{"key":"463_CR111","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1006\/geno.1998.5639","volume":"55","author":"S Verhaagh","year":"1999","unstructured":"Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999) Cloning of the mouse and human solute carrier 22a3 (Slc22a3\/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26\u2013q27. Genomics 55:209\u2013218","journal-title":"Genomics"},{"key":"463_CR112","doi-asserted-by":"publisher","first-page":"2846","DOI":"10.1523\/JNEUROSCI.5147-03.2004","volume":"24","author":"V Vialou","year":"2004","unstructured":"Vialou V, Amphoux A, Zwart R et al (2004) Organic cation transporter 3 (Slc22a3) is implicated in salt-intake regulation. J Neurosci 24:2846\u20132851. https:\/\/doi.org\/10.1523\/JNEUROSCI.5147-03.2004","journal-title":"J Neurosci"},{"key":"463_CR113","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1016\/j.neuroscience.2006.09.058","volume":"144","author":"V Vialou","year":"2007","unstructured":"Vialou V, Balasse L, Dumas S et al (2007) Neurochemical characterization of pathways expressing plasma membrane monoamine transporter in the rat brain. Neuroscience 144:616\u2013622. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.09.058","journal-title":"Neuroscience"},{"key":"463_CR114","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1111\/j.1471-4159.2008.05506.x","volume":"106","author":"V Vialou","year":"2008","unstructured":"Vialou V, Balasse L, Callebert J et al (2008) Altered aminergic neurotransmission in the brain of organic cation transporter 3-deficient mice. J Neurochem 106:1471\u20131482. https:\/\/doi.org\/10.1111\/j.1471-4159.2008.05506.x","journal-title":"J Neurochem"},{"key":"463_CR115","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1002\/cpt.442","volume":"100","author":"J Wang","year":"2016","unstructured":"Wang J (2016) The plasma membrane monoamine transporter (PMAT): structure, function, and role in organic cation disposition. Clin Pharmacol Ther 100:489\u2013499. https:\/\/doi.org\/10.1002\/cpt.442","journal-title":"Clin Pharmacol Ther"},{"key":"463_CR116","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1152\/physrev.00040.2003.-Organic","volume":"84","author":"SH Wright","year":"2004","unstructured":"Wright SH, Dantzler WH (2004) Molecular and cellular physiology of renal organic cation and anion transport. Am J Physiol Physiol 84:987\u20131049. https:\/\/doi.org\/10.1152\/physrev.00040.2003.-Organic","journal-title":"Am J Physiol Physiol"},{"key":"463_CR117","doi-asserted-by":"publisher","first-page":"32776","DOI":"10.1074\/jbc.273.49.32776","volume":"273","author":"X Wu","year":"1998","unstructured":"Wu X, Kekuda R, Huang W et al (1998a) Identity of the organic cation transporter OCT3 as the extraneuronal monoamine transporter (uptake2) and evidence for the expression of the transporter in the brain. J Biol Chem 273:32776\u201332786. https:\/\/doi.org\/10.1074\/jbc.273.49.32776","journal-title":"J Biol Chem"},{"key":"463_CR118","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1006\/bbrc.1998.8669","volume":"246","author":"X Wu","year":"1998","unstructured":"Wu X, Prasad PD, Leibach FH, Ganapathy V (1998b) cDNA sequence, transport function, and genomic organization of human OCTN2, a new member of the organic cation transporter family. Biochem Biophys Res Commun 246:589\u2013595. https:\/\/doi.org\/10.1006\/bbrc.1998.8669","journal-title":"Biochem Biophys Res Commun"},{"key":"463_CR119","first-page":"1482","volume":"290","author":"X Wu","year":"1999","unstructured":"Wu X, Huang W, Prasad PD et al (1999) Functional characteristics and tissue distribution pattern of organic cation transporter 2 (OCTN2), an organic cation\/carnitine transporter. J Pharmacol Exp Ther 290:1482\u20131492","journal-title":"J Pharmacol Exp Ther"},{"key":"463_CR120","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/S0005-2736(00)00189-9","volume":"1466","author":"X Wu","year":"2000","unstructured":"Wu X, George RL, Huang W et al (2000) Structural and functional characteristics and tissue distribution pattern of rat OCTN1, an organic cation transporter, cloned from placenta. Biochim Biophys Acta Biomembr 1466:315\u2013327. https:\/\/doi.org\/10.1016\/S0005-2736(00)00189-9","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"463_CR121","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/jcbfm.2014.162","volume":"35","author":"KC Wu","year":"2015","unstructured":"Wu KC, Lu YH, Peng YH et al (2015a) Decreased expression of organic cation transporters, Oct1 and Oct2, in brain microvessels and its implication to MPTP-induced dopaminergic toxicity in aged mice. J Cereb Blood Flow Metab 35:37\u201347. https:\/\/doi.org\/10.1038\/jcbfm.2014.162","journal-title":"J Cereb Blood Flow Metab"},{"key":"463_CR122","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1111\/jnc.13363","volume":"135","author":"KC Wu","year":"2015","unstructured":"Wu KC, Lu YH, Peng YH et al (2015b) Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxins. J Neurochem 135:1178\u20131188. https:\/\/doi.org\/10.1111\/jnc.13363","journal-title":"J Neurochem"},{"key":"463_CR123","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s00702-009-0205-1","volume":"116","author":"T Wultsch","year":"2009","unstructured":"Wultsch T, Grimberg G, Schmitt A et al (2009) Decreased anxiety in mice lacking the organic cation transporter 3. J Neural Trans 116:689\u2013697. https:\/\/doi.org\/10.1007\/s00702-009-0205-1","journal-title":"J Neural Trans"},{"key":"463_CR124","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1080\/00498254.2017.1300707","volume":"48","author":"L Xiao","year":"2018","unstructured":"Xiao L, Xue Y, Zhang C et al (2018) The involvement of multidrug and toxin extrusion protein 1 in the distribution and excretion of berberine. Xenobiotica 48:314\u2013323","journal-title":"Xenobiotica"},{"key":"463_CR125","first-page":"768","volume":"289","author":"H Yabuuchi","year":"1999","unstructured":"Yabuuchi H, Tamai I, Nezu JI et al (1999) Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther 289:768\u2013773","journal-title":"J Pharmacol Exp Ther"},{"key":"463_CR126","doi-asserted-by":"publisher","first-page":"1355","DOI":"10.1111\/j.1471-4159.1973.tb06022.x","volume":"21","author":"H Yamamura","year":"1973","unstructured":"Yamamura H, Snyder S (1973) High affinity transport of choline into synaptosomes of rat brain. J Neurochem 21:1355\u20131374","journal-title":"J Neurochem"},{"key":"463_CR127","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1002\/glia.22484","volume":"61","author":"T Yoshikawa","year":"2013","unstructured":"Yoshikawa T, Naganuma F, Iida T et al (2013) Molecular mechanism of histamine clearance by primary human astrocytes. Glia 61:905\u2013916. https:\/\/doi.org\/10.1002\/glia.22484","journal-title":"Glia"},{"key":"463_CR128","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1124\/mol.51.6.913","volume":"51","author":"L Zhang","year":"1997","unstructured":"Zhang L, Dresser MJ, Gray AT et al (1997) Cloning and functional expression of a human liver organic cation transporter. Mol Pharmacol 51:913\u2013921","journal-title":"Mol Pharmacol"},{"key":"463_CR129","first-page":"354","volume":"286","author":"L Zhang","year":"1998","unstructured":"Zhang L, Schaner ME, Giacomini KM (1998) Functional characterization of an organic cation transporter (hOCT1) in a transiently transfected human cell line (HeLa). J Pharmacol Exp Ther 286:354\u2013361","journal-title":"J Pharmacol Exp Ther"},{"key":"463_CR130","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1152\/ajprenal.00367.2001","volume":"283","author":"X Zhang","year":"2002","unstructured":"Zhang X, Evans KK, Wright SH (2002) Molecular cloning of rabbit organic cation transporter rbOCT2 and functional comparisons with rbOCT1. Am J Physiol Ren Physiol 283:124\u2013133. https:\/\/doi.org\/10.1152\/ajprenal.00367.2001","journal-title":"Am J Physiol Ren Physiol"},{"key":"463_CR131","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1152\/ajprenal.00102.2007","volume":"293","author":"X Zhang","year":"2007","unstructured":"Zhang X, Cherrington NJ, Wright SH (2007) Molecular identification and functional characterization of rabbit MATE1 and MATE2-K. Am J Physiol Ren Physiol 293:360\u2013370. https:\/\/doi.org\/10.1152\/ajprenal.00102.2007","journal-title":"Am J Physiol Ren Physiol"},{"key":"463_CR132","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.bcp.2006.09.008","volume":"73","author":"M Zhou","year":"2007","unstructured":"Zhou M, Engel K, Wang J (2007) Evidence for significant contribution of a newly identified monoamine transporter (PMAT) to serotonin uptake in the human brain. Biochem Pharmacol 73:147\u2013154. https:\/\/doi.org\/10.1016\/j.bcp.2006.09.008","journal-title":"Biochem Pharmacol"},{"key":"463_CR133","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1471-4159.2010.06738.x","volume":"114","author":"H-J Zhu","year":"2010","unstructured":"Zhu H-J, Appel DI, Gr\u00fcndemann D, Markowitz JS (2010) Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem 114:142\u2013149. https:\/\/doi.org\/10.1111\/j.1471-4159.2010.06738.x","journal-title":"J Neurochem"},{"key":"463_CR134","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.phrs.2012.01.008","volume":"65","author":"H-J Zhu","year":"2012","unstructured":"Zhu H-J, Appel DI, Gr\u00fcndemann D et al (2012a) Evaluation of organic cation transporter 3 (SLC22A3) inhibition as a potential mechanism of antidepressant action. Pharmacol Res 65:491\u2013496. https:\/\/doi.org\/10.1016\/j.phrs.2012.01.008","journal-title":"Pharmacol Res"},{"key":"463_CR135","doi-asserted-by":"publisher","first-page":"1897","DOI":"10.1038\/jcbfm.2012.92","volume":"32","author":"P Zhu","year":"2012","unstructured":"Zhu P, Hata R, Ogasawara M et al (2012b) Targeted disruption of organic cation transporter 3 (Oct3) ameliorates ischemic brain damage through modulating histamine and regulatory T cells. J Cereb Blood Flow Metab 32:1897\u20131908. https:\/\/doi.org\/10.1038\/jcbfm.2012.92","journal-title":"J Cereb Blood Flow Metab"},{"key":"463_CR136","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1007\/s11095-018-2526-y","volume":"35","author":"P Zhu","year":"2018","unstructured":"Zhu P, Ye Z, Guo D et al (2018) Irinotecan alters the disposition of morphine via inhibition of organic cation transporter 1 (OCT1) and 2 (OCT2). Pharm Res 35:243. https:\/\/doi.org\/10.1007\/s11095-018-2526-y","journal-title":"Pharm Res"},{"key":"463_CR137","doi-asserted-by":"publisher","first-page":"1312","DOI":"10.1124\/dmd.108.023762","volume":"37","author":"O Zolk","year":"2009","unstructured":"Zolk O, Solbach TF, K\u00f6nig J, Fromm MF (2009) Functional characterization of the human organic cation transporter 2 variant p.270Ala>Ser. Drug Metab Dispos 37:1312\u20131318. https:\/\/doi.org\/10.1124\/dmd.108.023762","journal-title":"Drug Metab Dispos"},{"key":"463_CR138","doi-asserted-by":"publisher","first-page":"4188","DOI":"10.1128\/mcb.21.13.4188-4196.2001","volume":"21","author":"R Zwart","year":"2001","unstructured":"Zwart R, Verhaagh S, Buitelaar M et al (2001) Impaired activity of the extraneuronal monoamine transporter system known as uptake-2 in Orct3\/Slc22a3-deficient mice. Mol Cell Biol 21:4188\u20134196. https:\/\/doi.org\/10.1128\/mcb.21.13.4188-4196.2001","journal-title":"Mol Cell Biol"}],"container-title":["Handbook of Experimental Pharmacology","Organic Cation Transporters in the Central Nervous System"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2021_463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T23:35:42Z","timestamp":1635291342000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2021_463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"ISBN":["9783030829834","9783030829841"],"references-count":138,"URL":"https:\/\/doi.org\/10.1007\/164_2021_463","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"assertion":[{"value":"8 May 2021","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}