{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T03:17:25Z","timestamp":1781320645057,"version":"3.54.1"},"publisher-location":"Cham","reference-count":151,"publisher":"Springer International Publishing","isbn-type":[{"value":"9783031667756","type":"print"},{"value":"9783031667763","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024]]},"DOI":"10.1007\/164_2024_719","type":"book-chapter","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T19:01:58Z","timestamp":1718737318000},"page":"297-332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Adrenoceptors and Hypertension"],"prefix":"10.1007","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2827-214X","authenticated-orcid":false,"given":"Spoorthy","family":"Kulkarni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6598-9399","authenticated-orcid":false,"given":"Ian B.","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"719_CR1","unstructured":"Agency UHS (2021) Blood pressure: are your pipes in good working order? https:\/\/www.gov.uk\/government\/organisations\/uk-health-security-agency. https:\/\/ukhsa.blog.gov.uk\/2021\/09\/06\/blood-pressure-are-your-pipes-in-good-working-order\/"},{"key":"719_CR2","doi-asserted-by":"publisher","unstructured":"Ahles, A., Engelhardt, S. (2023). Genetic Variants of Adrenoceptors. In: Handbook of Experimental Pharmacology. Springer, Berlin, Heidelberg. https:\/\/doi.org\/10.1007\/164_2023_676","DOI":"10.1007\/164_2023_676"},{"key":"719_CR3","doi-asserted-by":"crossref","unstructured":"Al Khaja KAJ, Sequeira RP, Alkhaja AK, Damanhori AHH (2014) Drug treatment of hypertension in pregnancy: a critical review of adult guideline recommendations. J Hypertens 32(3)","DOI":"10.1097\/HJH.0000000000000069"},{"issue":"3","key":"719_CR4","first-page":"611","volume":"20","author":"A Albillos","year":"1994","unstructured":"Albillos A, Lled\u00f3 JL, Ba\u00f1ares R, Rossi I, Iborra J, Calleja JL et al (1994) Hemodynamic effects of \u03b1-adrenergic blockade with prazosin in cirrhotic patients with portal hypertension. Hepatology 20(3):611\u2013617","journal-title":"Hepatology"},{"issue":"1","key":"719_CR5","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1161\/01.CIR.6.1.131","volume":"6","author":"EV Allen","year":"1952","unstructured":"Allen EV (1952) Sympathectomy for essential hypertension. Circulation 6(1):131\u2013140","journal-title":"Circulation"},{"issue":"8","key":"719_CR6","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1177\/000331979404500801","volume":"45","author":"MA Alpert","year":"1994","unstructured":"Alpert MA, Concannon MD, Mukerji B, Mukerji V (1994) Pharmacotherapy of chronic pulmonary arterial hypertension: value and limitations: part I: primary pulmonary hypertension. Angiology 45(8):667\u2013676","journal-title":"Angiology"},{"issue":"2","key":"719_CR7","first-page":"95","volume":"15","author":"A Al-Sharefi","year":"2019","unstructured":"Al-Sharefi A, Javaid U, Perros P, Ealing J, Truran P, Nag S et al (2019) Clinical presentation and outcomes of phaeochromocytomas\/paragangliomas in neurofibromatosis type 1. Eur Endocrinol 15(2):95\u2013100","journal-title":"Eur Endocrinol"},{"issue":"2","key":"719_CR8","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1161\/01.HYP.14.2.177","volume":"14","author":"EA Anderson","year":"1989","unstructured":"Anderson EA, Sinkey CA, Lawton WJ, Mark AL (1989) Elevated sympathetic nerve activity in borderline hypertensive humans. Evidence from direct intraneural recordings. Hypertension 14(2):177\u2013183","journal-title":"Hypertension"},{"issue":"3","key":"719_CR9","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1038\/sj.bjp.0706048","volume":"144","author":"JG Baker","year":"2005","unstructured":"Baker JG (2005) The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol 144(3):317\u2013322","journal-title":"Br J Pharmacol"},{"issue":"3","key":"719_CR10","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1136\/thoraxjnl-2016-208412","volume":"72","author":"JG Baker","year":"2017","unstructured":"Baker JG, Wilcox RG (2017) \u03b2-Blockers, heart disease and COPD: current controversies and uncertainties. Thorax 72(3):271\u2013276","journal-title":"Thorax"},{"key":"719_CR11","doi-asserted-by":"crossref","unstructured":"Baker J, Balaji P, Bond R, Bylund D, Eikenburg D, Graham R et al (2023) Adrenoceptors in GtoPdb 2023(1):2023","DOI":"10.2218\/gtopdb\/F4\/2023.1"},{"issue":"6","key":"719_CR12","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1002\/hep.1840360612","volume":"36","author":"R Banares","year":"2002","unstructured":"Banares R, Moitinho E, Matilla A, Garcia-Pagan JC, Lampreave JL, Piera C et al (2002) Randomized comparison of long-term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis. Hepatology 36(6):1367\u20131373","journal-title":"Hepatology"},{"issue":"7","key":"719_CR13","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1136\/hrt.2008.150888","volume":"95","author":"E Barbato","year":"2009","unstructured":"Barbato E (2009) Role of adrenergic receptors in human coronary vasomotion. Heart 95(7):603\u2013608","journal-title":"Heart"},{"issue":"25","key":"719_CR14","doi-asserted-by":"publisher","first-page":"2006","DOI":"10.1093\/eurheartj\/ehz300","volume":"40","author":"T Beaney","year":"2019","unstructured":"Beaney T, Burrell LM, Castillo RR, Charchar FJ, Cro S, Damasceno A et al (2019) May measurement month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension. Eur Heart J 40(25):2006\u20132017","journal-title":"Eur Heart J"},{"issue":"15","key":"719_CR15","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1056\/NEJMoa1402670","volume":"370","author":"DL Bhatt","year":"2014","unstructured":"Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT et al (2014) A controlled trial of renal denervation for resistant hypertension. N Engl J Med 370(15):1393\u20131401","journal-title":"N Engl J Med"},{"issue":"6","key":"719_CR16","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1111\/j.1365-2125.1984.tb02413.x","volume":"17","author":"D Bihari","year":"1984","unstructured":"Bihari D, Westaby D, Gimson A, Crossley I, Harry J, Williams R (1984) Reductions in portal pressure by selective beta 2-adrenoceptor blockade in patients with cirrhosis and portal hypertension. Br J Clin Pharmacol 17(6):753\u2013757","journal-title":"Br J Clin Pharmacol"},{"issue":"2","key":"719_CR17","first-page":"243","volume":"8","author":"V Bisogni","year":"2016","unstructured":"Bisogni V, Pengo MF, Maiolino G, Rossi GP (2016) The sympathetic nervous system and catecholamines metabolism in obstructive sleep apnoea. J Thorac Dis 8(2):243\u2013254","journal-title":"J Thorac Dis"},{"issue":"1","key":"719_CR18","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/imj.12590","volume":"45","author":"S Bloom","year":"2015","unstructured":"Bloom S, Kemp W, Lubel J (2015) Portal hypertension: pathophysiology, diagnosis and management. Intern Med J 45(1):16\u201326","journal-title":"Intern Med J"},{"issue":"6","key":"719_CR19","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1002\/hep.1840040617","volume":"4","author":"J Bosch","year":"1984","unstructured":"Bosch J, Masti R, Kravetz D, Bruix J, Gaya J, Rigau J, Rodes J (1984) Effects of propranolol on azygos venous blood flow and hepatic and systemic hemodynamics in cirrhosis. Hepatology 4(6):1200\u20131205","journal-title":"Hepatology"},{"issue":"1 Suppl","key":"719_CR20","doi-asserted-by":"publisher","first-page":"S121","DOI":"10.1016\/j.jhep.2015.01.003","volume":"62","author":"J Bosch","year":"2015","unstructured":"Bosch J, Groszmann RJ, Shah VH (2015) Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments. J Hepatol 62(1 Suppl):S121\u2013S130","journal-title":"J Hepatol"},{"issue":"3","key":"719_CR21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1111\/j.1365-2125.1994.tb04342.x","volume":"38","author":"AJ Bowman","year":"1994","unstructured":"Bowman AJ, Chen CP, Ford GA (1994) Nitric oxide mediated venodilator effects of nebivolol. Br J Clin Pharmacol 38(3):199\u2013204","journal-title":"Br J Clin Pharmacol"},{"issue":"3","key":"719_CR22","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1161\/01.RES.59.3.297","volume":"59","author":"MR Bristow","year":"1986","unstructured":"Bristow MR, Ginsburg R, Umans V, Fowler M, Minobe W, Rasmussen R et al (1986) Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure. Circ Res 59(3):297\u2013309","journal-title":"Circ Res"},{"issue":"4","key":"719_CR23","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0009-9236(03)00223-6","volume":"74","author":"O-E Brodde","year":"2003","unstructured":"Brodde O-E, Stein CM (2003) The Gly389Arg \u03b21-adrenergic receptor polymorphism: a predictor of response to \u03b2-blocker treatment? Clin Pharmacol Ther 74(4):299\u2013302","journal-title":"Clin Pharmacol Ther"},{"issue":"6","key":"719_CR24","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1007\/s003950170003","volume":"96","author":"O-E Brodde","year":"2001","unstructured":"Brodde O-E, Bruck H, Leineweber K, Seyfarth T (2001) Presence, distribution and physiological function of adrenergic and muscarinic receptor subtypes in the human heart. Basic Res Cardiol 96(6):528\u2013538","journal-title":"Basic Res Cardiol"},{"issue":"6","key":"719_CR25","doi-asserted-by":"publisher","first-page":"E1479","DOI":"10.1152\/ajpendo.00664.2007","volume":"293","author":"DB Bylund","year":"2007","unstructured":"Bylund DB (2007) Alpha- and beta-adrenergic receptors: Ahlquist\u2019s landmark hypothesis of a single mediator with two receptors. Am J Physiol Endocrinol Metab 293(6):E1479\u2013E1481","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"719_CR26","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1152\/japplphysiol.90401.2008","volume":"105","author":"DD Christou","year":"2008","unstructured":"Christou DD, Seals DR (2008) Decreased maximal heart rate with aging is related to reduced \u03b2-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate. J Appl Physiol 105(1):24\u201329","journal-title":"J Appl Physiol"},{"issue":"1","key":"719_CR27","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1152\/advan.00074.2010","volume":"35","author":"PS Clifford","year":"2011","unstructured":"Clifford PS (2011) Local control of blood flow. Adv Physiol Educ 35(1):5\u201315","journal-title":"Adv Physiol Educ"},{"issue":"2","key":"719_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1751-7176.2011.00553.x","volume":"14","author":"JR Cockcroft","year":"2012","unstructured":"Cockcroft JR, Pedersen ME (2012) \u03b2-Blockade: benefits beyond blood pressure reduction? J Clin Hypertens (Greenwich) 14(2):112\u2013120","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"3","key":"719_CR29","first-page":"1067","volume":"274","author":"JR Cockcroft","year":"1995","unstructured":"Cockcroft JR, Chowienczyk PJ, Brett SE, Chen CP, Dupont AG, Nueten LV et al (1995) Nebivolol vasodilates human forearm vasculature: evidence for an L-arginine\/NO-dependent mechanism. J Pharmacol Exp Ther 274(3):1067","journal-title":"J Pharmacol Exp Ther"},{"issue":"10159","key":"719_CR30","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1016\/S0140-6736(18)32225-6","volume":"392","author":"Collaborators GRF","year":"2018","unstructured":"Collaborators GRF (2018) Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392(10159) 1474-547X (Electronic):1923\u20131994","journal-title":"Lancet"},{"issue":"8306","key":"719_CR31","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/S0140-6736(82)90067-8","volume":"2","author":"JC Colman","year":"1982","unstructured":"Colman JC, Jennings GL, McLean AJ, Mignot PR, Dudley FJ (1982) Propranolol in decompensated alcoholic cirrhosis. Lancet 2(8306):1040\u20131041","journal-title":"Lancet"},{"issue":"2090-004X (Prin","key":"719_CR32","first-page":"6138132","volume":"2020","author":"B Cvenkel","year":"2020","unstructured":"Cvenkel B, Kolko M (2020) Current medical therapy and future trends in the management of glaucoma treatment. J Ophthalmol 2020(2090-004X (Print)):6138132","journal-title":"J Ophthalmol"},{"issue":"2","key":"719_CR33","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1093\/ajcn\/25.2.231","volume":"25","author":"LK Dahl","year":"1972","unstructured":"Dahl LK (1972) Salt and hypertension. Am J Clin Nutr 25(2):231\u2013244","journal-title":"Am J Clin Nutr"},{"issue":"9311","key":"719_CR34","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/S0140-6736(02)08089-3","volume":"359","author":"B Dahl\u00f6f","year":"2002","unstructured":"Dahl\u00f6f B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U et al (2002) Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet 359(9311):995\u20131003","journal-title":"Lancet"},{"issue":"9489","key":"719_CR35","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1016\/S0140-6736(05)67185-1","volume":"366","author":"B Dahl\u00f6f","year":"2005","unstructured":"Dahl\u00f6f B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M et al (2005) Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian cardiac outcomes trial-blood pressure lowering arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 366(9489):895\u2013906","journal-title":"Lancet"},{"issue":"4","key":"719_CR36","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.jhep.2021.12.022","volume":"76","author":"R de Franchis","year":"2022","unstructured":"de Franchis R, Bosch J, Garcia-Tsao G, Reiberger T, Ripoll C, Abraldes JG et al (2022) Baveno VII \u2013 renewing consensus in portal hypertension. J Hepatol 76(4):959\u2013974","journal-title":"J Hepatol"},{"issue":"1","key":"719_CR37","doi-asserted-by":"publisher","first-page":"S118","DOI":"10.1038\/sj.jhh.1001356","volume":"16","author":"V DeQuattro","year":"2002","unstructured":"DeQuattro V, Li D (2002) Sympatholytic therapy in primary hypertension: a user friendly role for the future. J Hum Hypertens 16(1):S118\u2013SS23","journal-title":"J Hum Hypertens"},{"issue":"2","key":"719_CR38","doi-asserted-by":"publisher","first-page":"R245","DOI":"10.1152\/ajpregu.00647.2009","volume":"298","author":"GF DiBona","year":"2009","unstructured":"DiBona GF, Esler M (2009) Translational medicine: the antihypertensive effect of renal denervation. Am J Physiol Regul Integr Comp Physiol 298(2):R245\u2013RR53","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"719_CR39","doi-asserted-by":"publisher","first-page":"22","DOI":"10.2174\/1573402114666180918102735","volume":"15","author":"GT do Vale","year":"2019","unstructured":"do Vale GT, Ceron CS, Gonzaga NA, Simplicio JA, Padovan JC (2019) Three generations of beta-blockers: history, class differences and clinical applicability. Curr Hypertens Rev 15(1):22\u201331","journal-title":"Curr Hypertens Rev"},{"issue":"17","key":"719_CR40","doi-asserted-by":"publisher","first-page":"9487","DOI":"10.1073\/pnas.94.17.9487","volume":"94","author":"AD Eckhart","year":"1997","unstructured":"Eckhart AD, Yang N, Xin X, Faber JE (1997) Characterization of the \u03b11B-adrenergic receptor gene promoter region and hypoxia regulatory elements in vascular smooth\u2009muscle. Proc Natl Acad Sci 94(17):9487\u20139492","journal-title":"Proc Natl Acad Sci"},{"issue":"8","key":"719_CR41","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1056\/NEJM197702242960801","volume":"296","author":"M Esler","year":"1977","unstructured":"Esler M, Julius S, Zweifler A, Randall O, Harburg E, Gardiner H, DeQuattro V (1977) Mild high-renin essential hypertension. N Engl J Med 296(8):405\u2013411","journal-title":"N Engl J Med"},{"issue":"1","key":"719_CR42","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1161\/01.HYP.11.1.3","volume":"11","author":"M Esler","year":"1988","unstructured":"Esler M, Jennings G, Korner P, Willett I, Dudley F, Hasking G et al (1988) Assessment of human sympathetic nervous system activity from measurements of norepinephrine turnover. Hypertension 11(1):3\u201320","journal-title":"Hypertension"},{"issue":"4","key":"719_CR43","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1152\/physrev.1990.70.4.963","volume":"70","author":"M Esler","year":"1990","unstructured":"Esler M, Jennings G, Lambert G, Meredith I, Horne M, Eisenhofer G (1990) Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions. Physiol Rev 70(4):963\u2013985","journal-title":"Physiol Rev"},{"issue":"10022","key":"719_CR44","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/S0140-6736(15)01225-8","volume":"387","author":"D Ettehad","year":"2016","unstructured":"Ettehad D, Emdin CA, Kiran A, Anderson SG, Callender T, Emberson J et al (2016) Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 387(10022):957\u2013967","journal-title":"Lancet"},{"issue":"5","key":"719_CR45","doi-asserted-by":"publisher","first-page":"H2316","DOI":"10.1152\/ajpheart.00792.2006","volume":"292","author":"JE Faber","year":"2007","unstructured":"Faber JE, Szymeczek CL, Cotecchia S, Thomas SA, Tanoue A, Tsujimoto G, Zhang H (2007) Alpha1-adrenoceptor-dependent vascular hypertrophy and remodeling in murine hypoxic pulmonary hypertension. Am J Physiol Heart Circ Physiol 292(5):H2316\u2013H2323","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"719_CR46","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1038\/s41371-023-00875-1","volume":"38","author":"L Faconti","year":"2024","unstructured":"Faconti L, Kulkarni S, Delles C, Kapil V, Lewis P, Glover M et al (2024) Diagnosis and management of primary hyperaldosteronism in patients with hypertension: a practical approach endorsed by the British and Irish hypertension society. J Hum Hypertens 38(1):8\u201318","journal-title":"J Hum Hypertens"},{"issue":"4","key":"719_CR47","first-page":"334","volume":"45","author":"FM Findlay","year":"1936","unstructured":"Findlay FM (1936) Hypertension: its surgical approach. Cal West Med 45(4):334\u2013340","journal-title":"Cal West Med"},{"issue":"2","key":"719_CR48","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1001\/jama.2016.19043","volume":"317","author":"MH Forouzanfar","year":"2017","unstructured":"Forouzanfar MH, Liu P, Roth GA, Ng M, Biryukov S, Marczak L et al (2017) Global burden of hypertension and systolic blood pressure of at least 110 to 115 mmHg, 1990-2015. JAMA 317(2):165\u2013182","journal-title":"JAMA"},{"issue":"6","key":"719_CR49","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.1161\/01.CIR.92.6.1448","volume":"92","author":"RR Freedman","year":"1995","unstructured":"Freedman RR, Baer RP, Mayes MD (1995) Blockade of vasospastic attacks by \u03b12-adrenergic but not \u03b11-adrenergic antagonists in idiopathic Raynaud\u2019s disease. Circulation 92(6):1448\u20131451","journal-title":"Circulation"},{"key":"719_CR50","doi-asserted-by":"crossref","unstructured":"Fujio H, Nakamura K, Matsubara H, Kusano KF, Miyaji K, Nagase S et al (2006) Carvedilol inhibits proliferation of cultured pulmonary artery smooth muscle cells of patients with idiopathic pulmonary arterial hypertension. J Cardiovasc Pharmacol 47(2)","DOI":"10.1097\/01.fjc.0000201359.58174.c8"},{"issue":"5","key":"719_CR51","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1210\/jc.2015-4061","volume":"101","author":"JW Funder","year":"2016","unstructured":"Funder JW, Carey RM, Mantero F, Murad MH, Reincke M, Shibata H et al (2016) The management of primary aldosteronism: case detection, diagnosis, and treatment: an endocrine society clinical practice Guideline. J Clin Endocrinol Metabol 101(5):1889\u20131916","journal-title":"J Clin Endocrinol Metabol"},{"key":"719_CR52","doi-asserted-by":"publisher","first-page":"100721","DOI":"10.1016\/j.cophys.2023.100721","volume":"36","author":"J Gambardella","year":"2023","unstructured":"Gambardella J, Fiordelisi A, Avvisato R, Buonaiuto A, Cerasuolo FA, Sorriento D, Iaccarino G (2023) Adrenergic receptors in endothelial and vascular smooth muscle cells. Curr Opin Physio 36:100721","journal-title":"Curr Opin Physio"},{"issue":"4","key":"719_CR53","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1161\/HYPERTENSIONAHA.114.03738","volume":"64","author":"A Gamboa","year":"2014","unstructured":"Gamboa A, Okamoto LE, Arnold AC, Figueroa RA, Diedrich A, Raj SR et al (2014) Autonomic blockade improves insulin sensitivity in obese subjects. Hypertension 64(4):867\u2013874","journal-title":"Hypertension"},{"issue":"2","key":"719_CR54","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/0091-7435(87)90087-9","volume":"16","author":"RJ Garrison","year":"1987","unstructured":"Garrison RJ, Kannel WB, Stokes J, Castelli WP (1987) Incidence and precursors of hypertension in young adults: the Framingham offspring study. Prev Med 16(2):235\u2013251","journal-title":"Prev Med"},{"issue":"15","key":"719_CR55","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1001\/jama.283.15.1967","volume":"283","author":"Group ACR","year":"2000","unstructured":"Group ACR (2000) Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). ALLHAT Collaborative Research Group. JAMA 283(15):1967\u20131975","journal-title":"JAMA"},{"issue":"22","key":"719_CR56","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1056\/NEJMoa1511939","volume":"373","author":"SR Group","year":"2015","unstructured":"Group SR, Wright JT Jr, Williamson JD, Whelton PK, Snyder JK, Sink KM et al (2015) A randomized trial of intensive versus standard blood-pressure control. N Engl J Med 373(22):2103\u20132116","journal-title":"N Engl J Med"},{"issue":"2","key":"719_CR57","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1080\/08037050801972923","volume":"17","author":"H Gudmundsdottir","year":"2008","unstructured":"Gudmundsdottir H, Strand AH, H\u00f8ieggen A, Reims HM, Westheim AS, Eide IK et al (2008) Do screening blood pressure and plasma catecholamines predict development of hypertension? Twenty-year follow-up of middle-aged men. Blood Press 17(2):94\u2013103","journal-title":"Blood Press"},{"issue":"10","key":"719_CR58","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1016\/S0149-2918(99)80052-6","volume":"21","author":"RM Guthrie","year":"1999","unstructured":"Guthrie RM, Siegel RL (1999) A multicenter, community-based study of doxazosin in the treatment of concomitant hypertension and symptomatic benign prostatic hyperplasia: the hypertension and BPH intervention trial (HABIT). Clin Ther 21(10):1732\u20131748","journal-title":"Clin Ther"},{"issue":"5014","key":"719_CR59","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1126\/science.2063193","volume":"252","author":"AC Guyton","year":"1991","unstructured":"Guyton AC (1991) Blood pressure control \u2013 special role of the kidneys and body fluids. Science 252(5014):1813\u20131816","journal-title":"Science"},{"issue":"10","key":"719_CR60","first-page":"2248","volume":"10","author":"AC Guyton","year":"1969","unstructured":"Guyton AC, Fau-Coleman TG, Coleman TG (1969) Quantitative analysis of the pathophysiology of hypertension. J Am Soc Nephrol 10(10):2248\u20132258. 1046\u20136673 (Print)","journal-title":"J Am Soc Nephrol"},{"issue":"4\u20136","key":"719_CR61","first-page":"436","volume":"14","author":"J Harlos","year":"2008","unstructured":"Harlos J, Heidland A (2008) Hypertension as cause and consequence of renal disease in the 19th century. Am J Nephrol 14(4\u20136):436\u2013442","journal-title":"Am J Nephrol"},{"issue":"4","key":"719_CR62","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1681\/ASN.2019060599","volume":"31","author":"L Hering","year":"2020","unstructured":"Hering L, Rahman M, Hoch H, Mark\u00f3 L, Yang G, Reil A et al (2020) \u03b12A-Adrenoceptors modulate renal sympathetic neurotransmission and protect against hypertensive kidney disease. J Am Soc Nephrol 31(4):783\u2013798","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"719_CR63","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1042\/cs0630029","volume":"63","author":"P Hillon","year":"1982","unstructured":"Hillon P, Blanchet L, Lebrec D (1982) Effect of propranolol on hepatic blood flow in normal and portal hypertensive rats. Clin Sci 63(1):29\u201332","journal-title":"Clin Sci"},{"issue":"1","key":"719_CR64","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.119.13820","volume":"75","author":"TC Hinton","year":"2020","unstructured":"Hinton TC, Adams ZH, Baker RP, Hope KA, Paton JFR, Hart EC, Nightingale AK (2020) Investigation and treatment of high blood pressure in young people. Hypertension 75(1):16\u201322","journal-title":"Hypertension"},{"issue":"6","key":"719_CR65","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1161\/CIRCRESAHA.112.272682","volume":"111","author":"HP Holthoff","year":"2012","unstructured":"Holthoff HP, Zeibig S, Jahns-Boivin V, Bauer J, Lohse MJ, K\u00e4\u00e4b S et al (2012) Detection of anti-\u03b21-AR autoantibodies in heart failure by a cell-based competition ELISA. Circ Res 111(6):675\u2013684","journal-title":"Circ Res"},{"issue":"2","key":"719_CR66","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1001\/archinte.1931.00140200003001","volume":"47","author":"LM Hurxthal","year":"1931","unstructured":"Hurxthal LM (1931) Blood pressure before and after operation in hyperthyroidism. Arch Intern Med 47(2):167\u2013181","journal-title":"Arch Intern Med"},{"issue":"12","key":"719_CR67","doi-asserted-by":"publisher","first-page":"2337","DOI":"10.1253\/circj.CJ-09-0213","volume":"73","author":"M Ishikawa","year":"2009","unstructured":"Ishikawa M, Sato N, Asai K, Takano T, Mizuno K (2009) Effects of a pure alpha\/beta-adrenergic receptor blocker on monocrotaline-induced pulmonary arterial hypertension with right ventricular hypertrophy in rats. Circ J 73(12):2337\u20132341","journal-title":"Circ J"},{"issue":"20","key":"719_CR68","doi-asserted-by":"publisher","first-page":"2424","DOI":"10.1161\/hc4501.099308","volume":"104","author":"PP Jones","year":"2001","unstructured":"Jones PP, Shapiro LF, Keisling GA, Jordan J, Shannon JR, Quaife RA, Seals DR (2001) Altered autonomic support of arterial blood pressure with age in healthy men. Circulation 104(20):2424\u20132429","journal-title":"Circulation"},{"issue":"2, Part 2","key":"719_CR69","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/0002-8703(88)90557-1","volume":"116","author":"S Julius","year":"1988","unstructured":"Julius S (1988) Transition from high cardiac output to elevated vascular resistance in hypertension. Am Heart J 116(2, Part 2):600\u2013606","journal-title":"Am Heart J"},{"key":"719_CR70","doi-asserted-by":"crossref","unstructured":"Julius S, Krause L, Schork NJ, Mejia AD, Jones KA, van de Ven C et al (1991) Hyperkinetic borderline hypertension in Tecumseh, Michigan. J Hypertens 9(1)","DOI":"10.1097\/00004872-199109010-00012"},{"issue":"1","key":"719_CR71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.2165\/11530710-000000000-00000","volume":"70","author":"O Kamp","year":"2010","unstructured":"Kamp O, Metra M, Bugatti S, Bettari L, Dei Cas A, Petrini N, Dei CL (2010) Nebivolol: haemodynamic effects and clinical significance of combined beta-blockade and nitric oxide release. Drugs 70(1):41\u201356","journal-title":"Drugs"},{"issue":"7","key":"719_CR72","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1056\/NEJM200102153440707","volume":"344","author":"I Klein","year":"2001","unstructured":"Klein I, Ojamaa K (2001) Thyroid hormone and the cardiovascular system. N Engl J Med 344(7):501\u2013509","journal-title":"N Engl J Med"},{"key":"719_CR73","doi-asserted-by":"crossref","unstructured":"Kopp UC (2011) Integrated systems physiology: from molecule to function to disease. Neural Control of renal function. Morgan & Claypool Life Sciences Copyright \u00a9 2011 by Morgan & Claypool Life Sciences, San Rafael","DOI":"10.4199\/C00034ED1V01Y201106ISP022"},{"key":"719_CR74","doi-asserted-by":"crossref","unstructured":"Kurnik D, Li C, Sofowora GG, Friedman EA, Muszkat M, Xie H-G et al (2008) Beta-1-adrenoceptor genetic variants and ethnicity independently affect response to beta-blockade. Pharmacogenet Genomics 18(10)","DOI":"10.1097\/FPC.0b013e328309733f"},{"issue":"5","key":"719_CR75","doi-asserted-by":"publisher","first-page":"518.e1","DOI":"10.1016\/j.ajog.2020.11.004","volume":"224","author":"J Lai","year":"2021","unstructured":"Lai J, Syngelaki A, Nicolaides KH, von Dadelszen P, Magee LA (2021) Impact of new definitions of preeclampsia at term on identification of adverse maternal and perinatal outcomes. Am J Obstet Gynecol 224(5):518.e1\u2013518e11","journal-title":"Am J Obstet Gynecol"},{"issue":"5","key":"719_CR76","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1161\/HYPERTENSIONAHA.107.094649","volume":"50","author":"E Lambert","year":"2007","unstructured":"Lambert E, Straznicky N, Schlaich M, Esler M, Dawood T, Hotchkin E, Lambert G (2007) Differing pattern of sympathoexcitation in normal-weight and obesity-related hypertension. Hypertension 50(5):862\u2013868","journal-title":"Hypertension"},{"issue":"2","key":"719_CR77","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1152\/physrev.1959.39.2.183","volume":"39","author":"NA Lassen","year":"1959","unstructured":"Lassen NA (1959) Cerebral blood flow and oxygen consumption in man. Physiol Rev 39(2):183\u2013238","journal-title":"Physiol Rev"},{"key":"719_CR78","doi-asserted-by":"crossref","unstructured":"Lebrec D, Nouel O, Corbic M, Benhamou JP. Propranolol \u2013 a medical treatment for portal hypertension? Lancet 1980;2(8187):180\u2013182","DOI":"10.1016\/S0140-6736(80)90063-X"},{"issue":"23","key":"719_CR79","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1056\/NEJM198112033052302","volume":"305","author":"D Lebrec","year":"1981","unstructured":"Lebrec D, Poynard T, Hillon P, Benhamou JP (1981) Propranolol for prevention of recurrent gastrointestinal bleeding in patients with cirrhosis: a controlled study. N Engl J Med 305(23):1371\u20131374","journal-title":"N Engl J Med"},{"issue":"5","key":"719_CR80","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1002\/hep.1840020502","volume":"2","author":"D Lebrec","year":"1982","unstructured":"Lebrec D, Hillon P, Munoz C, Goldfarb G, Nouel O, Benhamou JP (1982) The effect of propranolol on portal hypertension in patients with cirrhosis: a hemodynamic study. Hepatology 2(5):523\u2013527","journal-title":"Hepatology"},{"issue":"9","key":"719_CR81","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1001\/jama.1945.02860430001001","volume":"129","author":"RL Levy","year":"1945","unstructured":"Levy RL, White PD, Stroud WD, Hillman CC (1945) Transient tachycardia: prognostic significance alone and in association with transient hypertension. JAMA 129(9):585\u2013588","journal-title":"JAMA"},{"issue":"1","key":"719_CR82","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41371-023-00882-2","volume":"38","author":"P Lewis","year":"2024","unstructured":"Lewis P, George J, Kapil V, Poulter NR, Partridge S, Goodman J et al (2024) Adult hypertension referral pathway and therapeutic management: British and Irish hypertension society position statement. J Hum Hypertens 38(1):3\u20137","journal-title":"J Hum Hypertens"},{"issue":"2","key":"719_CR83","first-page":"1605","volume":"20","author":"L Ling","year":"2019","unstructured":"Ling L, Li G, Wang G, Meng D, Li Z, Zhang C (2019) Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis. Mol Med Rep 20(2):1605\u20131612","journal-title":"Mol Med Rep"},{"issue":"5276","key":"719_CR84","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1126\/science.273.5276.803","volume":"273","author":"RE Link","year":"1996","unstructured":"Link RE, Desai K, Hein L, Stevens ME, Chruscinski A, Bernstein D et al (1996) Cardiovascular regulation in mice lacking \u03b12-adrenergic receptor subtypes b and c. Science 273(5276):803\u2013805","journal-title":"Science"},{"issue":"10","key":"719_CR85","doi-asserted-by":"publisher","first-page":"300060520931625","DOI":"10.1177\/0300060520931625","volume":"48","author":"JY Liu","year":"2020","unstructured":"Liu JY, Guo LN, Peng WZ, Jiang Y, Wang AL, Guo XM, Xu ZS (2020) Efficacy and safety of nebivolol in hypertensive patients: a meta-analysis of randomized controlled trials. J Int Med Res 48(10):300060520931625","journal-title":"J Int Med Res"},{"issue":"3","key":"719_CR86","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1161\/HYPERTENSIONAHA.109.146290","volume":"55","author":"SJE Lucas","year":"2010","unstructured":"Lucas SJE, Tzeng YC, Galvin SD, Thomas KN, Ogoh S, Ainslie PN (2010) Influence of changes in blood pressure on cerebral perfusion and oxygenation. Hypertension 55(3):698\u2013705","journal-title":"Hypertension"},{"issue":"Suppl 2","key":"719_CR87","first-page":"107s","volume":"8","author":"P Lund-Johansen","year":"1979","unstructured":"Lund-Johansen P (1979) Comparative haemodynamic effects of labetalol, timolol, prazosin and the combination of tolamolol and prazosin. Br J Clin Pharmacol 8(Suppl 2):107s\u2013111s","journal-title":"Br J Clin Pharmacol"},{"key":"719_CR88","unstructured":"Lund-Johansen P (1983) Haemodynamics in essential hypertension. JIS R (ed)"},{"issue":"5_supplement","key":"719_CR89","doi-asserted-by":"publisher","first-page":"III54","DOI":"10.1161\/01.HYP.18.5_Suppl.III54","volume":"18","author":"P Lund-Johansen","year":"1991","unstructured":"Lund-Johansen P (1991) Twenty-year follow-up of hemodynamics in essential hypertension during rest and exercise. Hypertension 18(5_supplement):III54","journal-title":"Hypertension"},{"issue":"2","key":"719_CR90","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1365-2125.1979.tb00917.x","volume":"7","author":"P Lund-Johansen","year":"1979","unstructured":"Lund-Johansen P, Bakke OM (1979) Haemodynamic effects and plasma concentrations of labetalol during long-term treatment of essential hypertension. Br J Clin Pharmacol 7(2):169\u2013174","journal-title":"Br J Clin Pharmacol"},{"issue":"3","key":"719_CR91","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1007\/BF03029729","volume":"5","author":"P Lund-Johansen","year":"1991","unstructured":"Lund-Johansen P, Omvik P (1991) Acute and chronic hemodynamic effects of drugs with different actions on adrenergic receptors: a comparison between alpha blockers and different types of beta blockers with and without vasodilating effect. Cardiovasc Drugs Ther 5(3):605\u2013615","journal-title":"Cardiovasc Drugs Ther"},{"key":"719_CR92","doi-asserted-by":"crossref","unstructured":"Mah GT, Tejani AM, Musini VM (2009) Methyldopa for primary hypertension. Cochrane Database Syst Rev 4","DOI":"10.1002\/14651858.CD003893.pub3"},{"issue":"0959-5287 (Prin","key":"719_CR93","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1177\/095952877405700118","volume":"57","author":"FA Mahomed","year":"1874","unstructured":"Mahomed FA (1874) The etiology of Bright\u2019s disease and the Prealbuminuric stage. Med Chir Trans 57(0959-5287 (Print))):197\u2013228","journal-title":"Med Chir Trans"},{"key":"719_CR94","unstructured":"Mancia G, Kreutz R, Brunstr\u00f6m M, Burnier M, Grassi G, Januszewicz A et al (2023) ESH guidelines for the management of arterial hypertension the task force for the management of arterial hypertension of the European Society of Hypertension: endorsed by the International Society of Hypertension (ISH) and the European Renal Association (ERA). J Hypertens 41(12)"},{"issue":"2","key":"719_CR95","doi-asserted-by":"publisher","first-page":"S1006","DOI":"10.1016\/j.ajog.2020.10.052","volume":"226","author":"G Masini","year":"2022","unstructured":"Masini G, Foo LF, Tay J, Wilkinson IB, Valensise H, Gyselaers W, Lees CC (2022) Preeclampsia has two phenotypes which require different treatment strategies. Am J Obstet Gynecol 226(2):S1006\u2013S1S18","journal-title":"Am J Obstet Gynecol"},{"issue":"3","key":"719_CR96","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1002\/hep.1840100302","volume":"10","author":"R Mastai","year":"1989","unstructured":"Mastai R, Bosch J, Bruix J, Navasa M, Kravetz D, Rodes J (1989) Beta-blockade with propranolol and hepatic artery blood flow in patients with cirrhosis. Hepatology 10(3):269\u2013272","journal-title":"Hepatology"},{"issue":"13","key":"719_CR97","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1056\/NEJM199304013281303","volume":"328","author":"BJ Materson","year":"1993","unstructured":"Materson BJ, Reda DJ, Cushman WC, Massie BM, Freis ED, Kochar MS et al (1993) Single-drug therapy for hypertension in men \u2013 a comparison of six antihypertensive agents with placebo. N Engl J Med 328(13):914\u2013921","journal-title":"N Engl J Med"},{"issue":"3","key":"719_CR98","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1161\/01.HYP.0000200713.44895.38","volume":"47","author":"KA Matthews","year":"2006","unstructured":"Matthews KA, Zhu S, Tucker DC, Whooley MA (2006) Blood pressure reactivity to psychological stress and coronary calcification in the coronary artery risk development in young adults study. Hypertension 47(3):391\u2013395","journal-title":"Hypertension"},{"issue":"1","key":"719_CR99","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1007\/s12170-020-00663-3","volume":"15","author":"JD Mayeux","year":"2021","unstructured":"Mayeux JD, Pan IZ, Dechand J, Jacobs JA, Jones TL, McKellar SH et al (2021) Management of pulmonary arterial hypertension. Curr Cardiovasc Risk Rep 15(1):2","journal-title":"Curr Cardiovasc Risk Rep"},{"issue":"3","key":"719_CR100","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1080\/080370502760050421","volume":"11","author":"A Mazza","year":"2002","unstructured":"Mazza A, Gil-Extremera B, Maldonato A, Toutouzas T, Pessina AC (2002) Nebivolol vs amlodipine as first-line treatment of essential arterial hypertension in the elderly. Blood Press 11(3):182\u2013188","journal-title":"Blood Press"},{"issue":"4","key":"719_CR101","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.ando.2011.05.004","volume":"72","author":"A Mazza","year":"2011","unstructured":"Mazza A, Beltramello G, Armigliato M, Montemurro D, Zorzan S, Zuin M et al (2011) Arterial hypertension and thyroid disorders: what is important to know in clinical practice? Ann Endocrinol 72(4):296\u2013303","journal-title":"Ann Endocrinol"},{"issue":"3","key":"719_CR102","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s12020-013-0007-y","volume":"45","author":"A Mazza","year":"2014","unstructured":"Mazza A, Armigliato M, Marzola MC, Schiavon L, Montemurro D, Vescovo G et al (2014) Anti-hypertensive treatment in pheochromocytoma and paraganglioma: current management and therapeutic features. Endocrine 45(3):469\u2013478","journal-title":"Endocrine"},{"issue":"3","key":"719_CR103","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1161\/01.HYP.0000137983.45556.6e","volume":"44","author":"CM McEniery","year":"2004","unstructured":"McEniery CM, Schmitt M, Qasem A, Webb DJ, Avolio AP, Wilkinson IB, Cockcroft JR (2004) Nebivolol increases arterial distensibility in vivo. Hypertension 44(3):305\u2013310","journal-title":"Hypertension"},{"issue":"4","key":"719_CR104","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1038\/s41581-019-0244-2","volume":"16","author":"KT Mills","year":"2020","unstructured":"Mills KT, Stefanescu A, He J (2020) The global epidemiology of hypertension. Nat Rev Nephrol 16(4):223\u2013237","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"719_CR105","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1161\/01.RES.73.2.252","volume":"73","author":"JK Miyashiro","year":"1993","unstructured":"Miyashiro JK, Feigl EO (1993) Feedforward control of coronary blood flow via coronary beta-receptor stimulation. Circ Res 73(2):252\u2013263","journal-title":"Circ Res"},{"issue":"s8","key":"719_CR106","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1524-6175.2006.05836.x","volume":"8","author":"M Moser","year":"2006","unstructured":"Moser M (2006) Historical perspectives on the management of hypertension. J Clin Hypertens 8(s8):15\u201320","journal-title":"J Clin Hypertens"},{"key":"719_CR107","unstructured":"National Institute for Health and Care Excellence (NICE) (2019) Hypertension in pregnancy: diagnosis and management [Internet]"},{"key":"719_CR108","unstructured":"NICE (2022) National Institute for Health and Care Excellence. Hypertension in adults: diagnosis and management. NICE Guideline [NG136]. https:\/\/www.niceorguk\/guidance\/ng136"},{"issue":"7","key":"719_CR109","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1111\/jch.13277","volume":"20","author":"E O\u2019Brien","year":"2018","unstructured":"O\u2019Brien E, Kario K, Staessen JA, de la Sierra A, Ohkubo T (2018) Patterns of ambulatory blood pressure: clinical relevance and application. J Clin Hypertens (Greenwich) 20(7):1112\u20131115","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"4","key":"719_CR110","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/BF01856510","volume":"4","author":"P Omvik","year":"1990","unstructured":"Omvik P, Lund-Johansen P (1990) The initial hemodynamic response to newer antihypertensive agents at rest and during exercise: review of visacor, doxazosin, nisoldipine, tiapamil, perindoprilat, pinacidil, dilevalol, and carvedilol. Cardiovasc Drugs Ther 4(4):1135\u20131143","journal-title":"Cardiovasc Drugs Ther"},{"issue":"4","key":"719_CR111","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1007\/s11906-015-0537-1","volume":"17","author":"G Parati","year":"2015","unstructured":"Parati G, Ochoa JE, Lombardi C, Bilo G (2015) Blood pressure variability: assessment, predictive value, and potential as a therapeutic target. Curr Hypertens Rep 17(4):23","journal-title":"Curr Hypertens Rep"},{"issue":"6824","key":"719_CR112","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1136\/bmj.304.6824.405","volume":"304","author":"MW Party","year":"1992","unstructured":"Party MW (1992) Medical Research Council trial of treatment of hypertension in older adults: principal results. MRC Working Party. BMJ. Clinical research ed 304(6824):405\u2013412","journal-title":"BMJ"},{"issue":"2","key":"719_CR113","doi-asserted-by":"publisher","first-page":"R287","DOI":"10.1152\/ajpregu.00123.2002","volume":"283","author":"M Philipp","year":"2002","unstructured":"Philipp M, Brede M, Hein L (2002) Physiological significance of \u03b12-adrenergic receptor subtype diversity: one receptor is not enough. Am J Physiol Regul Integr Comp Physiol 283(2):R287\u2013RR95","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"5635","key":"719_CR114","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1136\/bmj.1.5635.7","volume":"1","author":"BN Prichard","year":"1969","unstructured":"Prichard BN, Gillam PM (1969) Treatment of hypertension with propranolol. Br Med J 1(5635):7\u201316","journal-title":"Br Med J"},{"issue":"4","key":"719_CR115","doi-asserted-by":"publisher","first-page":"e00602","DOI":"10.1002\/prp2.602","volume":"8","author":"RGW Proudman","year":"2020","unstructured":"Proudman RGW, Pupo AS, Baker JG (2020) The affinity and selectivity of \u03b1-adrenoceptor antagonists, antidepressants, and antipsychotics for the human \u03b11A, \u03b11B, and \u03b11D-adrenoceptors. Pharmacol Res Perspect 8(4):e00602","journal-title":"Pharmacol Res Perspect"},{"issue":"2","key":"719_CR116","doi-asserted-by":"publisher","first-page":"e00936","DOI":"10.1002\/prp2.936","volume":"10","author":"RGW Proudman","year":"2022","unstructured":"Proudman RGW, Akinaga J, Baker JG (2022) The affinity and selectivity of \u03b1-adrenoceptor antagonists, antidepressants and antipsychotics for the human \u03b12A, \u03b12B, and \u03b12C-adrenoceptors and comparison with human \u03b11 and \u03b2-adrenoceptors. Pharmacol Res Perspect 10(2):e00936","journal-title":"Pharmacol Res Perspect"},{"issue":"3","key":"719_CR117","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1136\/bjo.2005.081224","volume":"90","author":"HA Quigley","year":"2006","unstructured":"Quigley HA, Broman AT (2006) The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 90(3):262","journal-title":"Br J Ophthalmol"},{"issue":"4","key":"719_CR118","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1136\/gut.50.4.571","volume":"50","author":"H Reynaert","year":"2002","unstructured":"Reynaert H, Thompson MG, Thomas T, Geerts A (2002) Hepatic stellate cells: role in microcirculation and pathophysiology of portal hypertension. Gut 50(4):571","journal-title":"Gut"},{"issue":"1756\u20131833 (Elec","key":"719_CR119","doi-asserted-by":"publisher","first-page":"e067924","DOI":"10.1136\/bmj-2021-067924","volume":"376","author":"SC Rison","year":"2022","unstructured":"Rison SC, Carvalho C, Rull G, Robson J (2022) Investigating hypertension in younger patients. BMJ. Clinical research ed 376(1756\u20131833 (Electronic)):e067924","journal-title":"BMJ"},{"issue":"1","key":"719_CR120","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.amjms.2020.08.012","volume":"361","author":"AM Rivas","year":"2021","unstructured":"Rivas AM, Pena C, Kopel J, Dennis JA, Nugent K (2021) Hypertension and hyperthyroidism: association and pathogenesis. Am J Med Sci 361(1):3\u20137","journal-title":"Am J Med Sci"},{"issue":"5","key":"719_CR121","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1080\/08037050410016500","volume":"13","author":"T Rosenthal","year":"2004","unstructured":"Rosenthal T (2004) Contemplating the history of drug therapy for hypertension. Blood Press 13(5):262\u2013271","journal-title":"Blood Press"},{"issue":"1","key":"719_CR122","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1532-5415.1985.tb02854.x","volume":"33","author":"I Saito","year":"1985","unstructured":"Saito I, Ito K, Saruta T (1985) The effect of age on blood pressure in hyperthyroidism. J Am Geriatr Soc 33(1):19\u201322","journal-title":"J Am Geriatr Soc"},{"issue":"6","key":"719_CR123","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1378\/chest.115.6.1708","volume":"115","author":"SS Salvi","year":"1999","unstructured":"Salvi SS (1999) Alpha1-adrenergic hypothesis for pulmonary hypertension. Chest 115(6):1708\u20131719","journal-title":"Chest"},{"issue":"2","key":"719_CR124","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jacc.2012.10.011","volume":"61","author":"G Savarese","year":"2013","unstructured":"Savarese G, Costanzo P, Cleland John George F, Vassallo E, Ruggiero D, Rosano G, Perrone-Filardi P (2013) A meta-analysis reporting effects of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients without heart failure. J Am Coll Cardiol 61(2):131\u2013142","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"719_CR125","doi-asserted-by":"publisher","first-page":"116","DOI":"10.2165\/00002512-199101020-00004","volume":"1","author":"PJ Scarpace","year":"1991","unstructured":"Scarpace PJ, Turner N, Mader SL (1991) \u03b2-Adrenergic function in aging. Drugs Aging 1(2):116\u2013129","journal-title":"Drugs Aging"},{"key":"719_CR126","doi-asserted-by":"publisher","first-page":"102814","DOI":"10.1016\/j.autneu.2021.102814","volume":"234","author":"T Schlereth","year":"2021","unstructured":"Schlereth T, Morellini N, Lismont NCAM, Lemper C, Birklein F, Drummond PD (2021) Alpha 1 adrenoceptor expression in skin, nerves and blood vessels of patients with painful diabetic neuropathy. Auton Neurosci 234:102814","journal-title":"Auton Neurosci"},{"issue":"11","key":"719_CR127","doi-asserted-by":"publisher","first-page":"1254","DOI":"10.1161\/CIRCULATIONAHA.113.003904","volume":"129","author":"EW Seely","year":"2014","unstructured":"Seely EW, Ecker J (2014) Chronic hypertension in pregnancy. Circulation 129(11):1254\u20131261","journal-title":"Circulation"},{"issue":"5","key":"719_CR128","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1161\/HYPERTENSIONAHA.116.08792","volume":"69","author":"H Shabeeh","year":"2017","unstructured":"Shabeeh H, Khan S, Jiang B, Brett S, Melikian N, Casadei B et al (2017) Blood pressure in healthy humans is regulated by neuronal NO synthase. Hypertension 69(5):970\u2013976","journal-title":"Hypertension"},{"issue":"5","key":"719_CR129","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1161\/HYPERTENSIONAHA.110.154898","volume":"56","author":"C Shibao","year":"2010","unstructured":"Shibao C, Okamoto LE, Gamboa A, Yu C, Diedrich A, Raj SR et al (2010) Comparative efficacy of Yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure. Hypertension 56(5):847\u2013851","journal-title":"Hypertension"},{"issue":"5","key":"719_CR130","first-page":"407","volume":"40","author":"VA Skeberdis","year":"2004","unstructured":"Skeberdis VA (2004) Structure and function of beta3-adrenergic receptors. Medicina (Kaunas) 40(5):407\u2013413","journal-title":"Medicina (Kaunas)"},{"issue":"2","key":"719_CR131","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1023\/A:1007784109255","volume":"13","author":"C Smith","year":"1999","unstructured":"Smith C, Teitler M (1999) Beta-blocker selectivity at cloned human Beta1- and Beta2-adrenergic receptors. Cardiovasc Drugs Ther 13(2):123\u2013126","journal-title":"Cardiovasc Drugs Ther"},{"issue":"16","key":"719_CR132","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1001\/jama.1953.03690160001001","volume":"152","author":"RH Smithwick","year":"1953","unstructured":"Smithwick RH, Thompson JE (1953) Splanchnicectomy for essential hypertension: results in 1,266 cases. JAMA 152(16):1501\u20131504","journal-title":"JAMA"},{"issue":"5","key":"719_CR133","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/0024-3205(83)90796-8","volume":"33","author":"GL Stiles","year":"1983","unstructured":"Stiles GL, Taylor S, Lefkowitz RJ (1983) Human cardiac beta-adrenergic receptors: subtype heterogeneity delineated by direct radioligand binding. Life Sci 33(5):467\u2013473","journal-title":"Life Sci"},{"issue":"5914","key":"719_CR134","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1136\/bmj.2.5914.298","volume":"2","author":"GS Stokes","year":"1974","unstructured":"Stokes GS, Weber MA (1974) Prazosin: preliminary report and comparative studies with other antihypertensive agents. Br Med J 2(5914):298\u2013300","journal-title":"Br Med J"},{"issue":"5897","key":"719_CR135","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1136\/bmj.1.5897.60","volume":"1","author":"GS Stokes","year":"1974","unstructured":"Stokes GS, Weber MA, Thornell IR (1974) Beta-blockers and plasma renin activity in hypertension. Br Med J 1(5897):60\u201362","journal-title":"Br Med J"},{"key":"719_CR136","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1536\/ihj.19.66","volume":"19","author":"S Tanaka","year":"1978","unstructured":"Tanaka S, Fau-Takeshita A, Takeshita A, Fau-Tomoike H, Tomoike H, Fau-Nakamura M, Nakamura M (1978) Role of autonomic and non-autonomic circulatory components in borderline hypertension in young men. Jpn Heart J 19:66\u201373. 0021-4868 (Print)","journal-title":"Jpn Heart J"},{"issue":"6","key":"719_CR137","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1016\/j.jhep.2020.05.011","volume":"73","author":"L Tellez","year":"2020","unstructured":"Tellez L, Ibanez-Samaniego L, Perez Del Villar C, Yotti R, Martinez J, Carrion L et al (2020) Non-selective beta-blockers impair global circulatory homeostasis and renal function in cirrhotic patients with refractory ascites. J Hepatol 73(6):1404\u20131414","journal-title":"J Hepatol"},{"key":"719_CR138","doi-asserted-by":"crossref","unstructured":"Thomopoulos C, Parati G, Zanchetti A (2015) Effects of blood pressure-lowering on outcome incidence in hypertension: 5. Head-to-head comparisons of various classes of antihypertensive drugs \u2013 overview and meta-analyses. J Hypertens 33(7)","DOI":"10.1097\/HJH.0000000000000614"},{"issue":"9395","key":"719_CR139","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.1016\/S0140-6736(03)14739-3","volume":"362","author":"F Turnbull","year":"2003","unstructured":"Turnbull F, Blood Pressure Lowering Treatment Trialists Collaboration (2003) Effects of different blood-pressure-lowering regimens on major cardiovascular events: results of prospectively-designed overviews of randomised trials. Lancet 362(9395):1527\u20131535","journal-title":"Lancet"},{"issue":"2","key":"719_CR140","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/sj.jhh.1000571","volume":"12","author":"L Van Nueten","year":"1998","unstructured":"Van Nueten L, Taylor FR, Robertson JIS (1998) Nebivolol vs atenolol and placebo in essential hypertension: a double-blind randomised trial. J Hum Hypertens 12(2):135\u2013140","journal-title":"J Hum Hypertens"},{"issue":"16","key":"719_CR141","doi-asserted-by":"publisher","first-page":"2088","DOI":"10.1093\/eurheartj\/ehs075","volume":"33","author":"LC van Vark","year":"2012","unstructured":"van Vark LC, Bertrand M, Akkerhuis KM, Brugts JJ, Fox K, Mourad J-J, Boersma E (2012) Angiotensin-converting enzyme inhibitors reduce mortality in hypertension: a meta-analysis of randomized clinical trials of renin\u2013angiotensin\u2013aldosterone system inhibitors involving 158 998 patients. Eur Heart J 33(16):2088\u20132097","journal-title":"Eur Heart J"},{"issue":"10","key":"719_CR142","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1161\/01.CIR.96.10.3423","volume":"96","author":"M Vaz","year":"1997","unstructured":"Vaz M, Jennings G, Turner A, Cox H, Lambert G, Esler M (1997) Regional sympathetic nervous activity and oxygen consumption in obese normotensive human subjects. Circulation 96(10):3423\u20133429","journal-title":"Circulation"},{"issue":"5","key":"719_CR143","first-page":"290","volume":"132","author":"RO Vaz-de-Melo","year":"2014","unstructured":"Vaz-de-Melo RO, Giollo-J\u00fanior LT, Martinelli DD, Moreno-J\u00fanior H, Mota-Gomes MA, Cipullo JP et al (2014) Nebivolol reduces central blood pressure in stage I hypertensive patients: experimental single cohort study. Sao Paulo medical journal =. Rev Paul Med 132(5):290\u2013296","journal-title":"Rev Paul Med"},{"issue":"10","key":"719_CR144","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1161\/01.CIR.0000140724.90898.D3","volume":"110","author":"S Velez-Roa","year":"2004","unstructured":"Velez-Roa S, Ciarka A, Najem B, Vachiery JL, Naeije R, van de Borne P (2004) Increased sympathetic nerve activity in pulmonary artery hypertension. Circulation 110(10):1308\u20131312","journal-title":"Circulation"},{"issue":"10181","key":"719_CR145","doi-asserted-by":"publisher","first-page":"1597","DOI":"10.1016\/S0140-6736(18)31875-0","volume":"393","author":"C Villanueva","year":"2019","unstructured":"Villanueva C, Albillos A, Genesca J, Garcia-Pagan JC, Calleja JL, Aracil C et al (2019) Beta blockers to prevent decompensation of cirrhosis in patients with clinically significant portal hypertension (PREDESCI): a randomised, double-blind, placebo-controlled, multicentre trial. Lancet 393(10181):1597\u20131608","journal-title":"Lancet"},{"issue":"4","key":"719_CR146","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1002\/hep.1840070406","volume":"7","author":"J Vorobioff","year":"1987","unstructured":"Vorobioff J, Picabea E, Villavicencio R, Puccini V, Rossi O, Bordato J, Audano M (1987) Acute and chronic hemodynamic effects of propranolol in unselected cirrhotic patients. Hepatology 7(4):648\u2013653","journal-title":"Hepatology"},{"issue":"1756\u20131833 (Elec","key":"719_CR147","doi-asserted-by":"publisher","first-page":"l5119","DOI":"10.1136\/bmj.l5119","volume":"366","author":"K Webster","year":"2019","unstructured":"Webster K, Fishburn S, Maresh M, Findlay SC, Chappell LC, Guideline C (2019) Diagnosis and management of hypertension in pregnancy: summary of updated NICE guidance. BMJ. Clinical research ed 366(1756\u20131833 (Electronic)):l5119","journal-title":"BMJ"},{"issue":"2","key":"719_CR148","doi-asserted-by":"publisher","first-page":"e1921618","DOI":"10.1001\/jamanetworkopen.2019.21618","volume":"3","author":"J Wei","year":"2020","unstructured":"Wei J, Galaviz KI, Kowalski AJ, Magee MJ, Haw JS, Narayan KMV, Ali MK (2020) Comparison of cardiovascular events among users of different classes of antihypertension medications: a systematic review and network meta-analysis. JAMA Netw Open 3(2):e1921618","journal-title":"JAMA Netw Open"},{"issue":"2","key":"719_CR149","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/0002-9343(77)90316-3","volume":"62","author":"P Weidmann","year":"1977","unstructured":"Weidmann P, Hirsch D, Beretta-Piccoli C, Reubi FC, Ziegler WH (1977) Interrelations among blood pressure, blood volume, plasma renin activity and urinary catecholamines in benign essential hypertension. Am J Med 62(2):209\u2013218","journal-title":"Am J Med"},{"issue":"1","key":"719_CR150","first-page":"Cd002003","volume":"1","author":"CS Wiysonge","year":"2017","unstructured":"Wiysonge CS, Bradley HA, Volmink J, Mayosi BM, Opie LH (2017) Beta-blockers for hypertension. Cochrane Database Syst Rev 1(1):Cd002003","journal-title":"Cochrane Database Syst Rev"},{"issue":"7 Pt 1","key":"719_CR151","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/S0895-7061(01)01293-6","volume":"14","author":"MR Wofford","year":"2001","unstructured":"Wofford MR, Anderson DC, Brown CA, Jones DW, Miller ME, Hall JE (2001) Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects. Am J Hypertens 14(7 Pt 1):694\u2013698","journal-title":"Am J Hypertens"}],"container-title":["Handbook of Experimental Pharmacology","Adrenoceptors"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2024_719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T19:07:06Z","timestamp":1725390426000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2024_719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"ISBN":["9783031667756","9783031667763"],"references-count":151,"URL":"https:\/\/doi.org\/10.1007\/164_2024_719","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"assertion":[{"value":"19 June 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}