{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:44:52Z","timestamp":1788565492209,"version":"build-2803163510"},"publisher-location":"Cham","reference-count":190,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783031802928","type":"print"},{"value":"9783031802935","type":"electronic"}],"license":[{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,25]],"date-time":"2024-09-25T00:00:00Z","timestamp":1727222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/164_2024_721","type":"book-chapter","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T19:02:10Z","timestamp":1727204530000},"page":"33-60","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Natural Products to Promote Vascular Health"],"prefix":"10.1007","author":[{"given":"Val\u00e9rie B.","family":"Schini-Kerth","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahima","family":"Diouf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hira","family":"Muzammel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amissi","family":"Said","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Auger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,9,25]]},"reference":[{"issue":"13","key":"721_CR1","doi-asserted-by":"publisher","first-page":"1992","DOI":"10.3390\/cells11131992","volume":"11","author":"IY Abdelgawad","year":"2022","unstructured":"Abdelgawad IY, Agostinucci K, Ismail SG, Grant MKO, Zordoky BNEA (2022) Hy926 cells and HUVECs share similar senescence phenotypes but respond differently to the senolytic drug ABT-263. Cells 11(13):1992. https:\/\/doi.org\/10.3390\/cells11131992","journal-title":"Cells"},{"issue":"1","key":"721_CR2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1053\/euhj.1999.1759","volume":"21","author":"S Agewall","year":"2000","unstructured":"Agewall S, Wright S, Doughty RN, Whalley GA, Duxbury M, Sharpe N (2000) Does a glass of red wine improve endothelial function? Eur Heart J 21(1):74\u201378","journal-title":"Eur Heart J"},{"issue":"1","key":"721_CR3","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1021\/jf048919f","volume":"53","author":"NA Al-Awwadi","year":"2005","unstructured":"Al-Awwadi NA, Araiz C, Bornet A, Delbosc S, Cristol JP, Linck N, Azay J, Teissedre PL, Cros G (2005) Extracts enriched in different polyphenolic families normalize increased cardiac NADPH oxidase expression while having differential effects on insulin resistance, hypertension, and cardiac hypertrophy in high-fructose-fed rats. J Agric Food Chem 53(1):151\u2013157. https:\/\/doi.org\/10.1021\/jf048919f","journal-title":"J Agric Food Chem"},{"issue":"3","key":"721_CR4","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/HJR.0b013e3282f4832f","volume":"15","author":"N Alexopoulos","year":"2008","unstructured":"Alexopoulos N, Vlachopoulos C, Aznaouridis K, Baou K, Vasiliadou C, Pietri P, Xaplanteris P, Stefanadi E, Stefanadis C (2008) The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil 15(3):300\u2013305. https:\/\/doi.org\/10.1097\/HJR.0b013e3282f4832f","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"issue":"10","key":"721_CR5","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1161\/CIRCRESAHA.116.307475","volume":"118","author":"I Alfaras","year":"2016","unstructured":"Alfaras I, Di Germanio C, Bernier M, Csiszar A, Ungvari Z, Lakatta EG, De Cabo R (2016) Pharmacological strategies to retard cardiovascular ageing. Circ Res 118(10):1626\u20131642. https:\/\/doi.org\/10.1161\/CIRCRESAHA.116.307475","journal-title":"Circ Res"},{"issue":"3","key":"721_CR6","doi-asserted-by":"publisher","first-page":"e57883","DOI":"10.1371\/journal.pone.0057883","volume":"8","author":"M Alhosin","year":"2013","unstructured":"Alhosin M, Anselm E, Rashid S, Kim JH, Frota Madeira SV, Bronner C, Schini-Kerth VB (2013) Redox-sensitive up-regulation of eNOS by purple grape juice in endothelial cells: role of PI3-kinase\/Akt, P38 MAPK, JNK, FoxO1 and FoxO3a. PLoS One 8(3):e57883. https:\/\/doi.org\/10.1371\/journal.pone.0057883","journal-title":"PLoS One"},{"key":"721_CR7","doi-asserted-by":"publisher","first-page":"104169","DOI":"10.1016\/j.jff.2020.104169","volume":"74","author":"AM Alves-Santos","year":"2020","unstructured":"Alves-Santos AM, Sugizaki CSA, Lima GC, Naves MMV (2020) Prebiotic effect of dietary polyphenols: a systematic review. J Funct Foods 74:104169. https:\/\/doi.org\/10.1016\/j.jff.2020.104169","journal-title":"J Funct Foods"},{"issue":"9","key":"721_CR8","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1017\/S0007114512003406","volume":"108","author":"R Andriantsitohaina","year":"2012","unstructured":"Andriantsitohaina R, Auger C, Chataigneau T, Etienne-Selloum N, Li H, Martinez MC, Schini-Kerth VB, Laher I (2012) Molecular mechanisms of the cardiovascular protective effects of polyphenols. Br J Nutr 108(9):1532\u20131549. https:\/\/doi.org\/10.1017\/S0007114512003406","journal-title":"Br J Nutr"},{"issue":"2","key":"721_CR9","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1016\/j.cardiores.2006.08.004","volume":"73","author":"E Anselm","year":"2007","unstructured":"Anselm E, Chataigneau M, Ndiaye M, Chataigneau T, Schini-Kerth VB (2007) Grape juice causes endothelium-dependent relaxation via a redox-sensitive Src- and Akt-dependent activation of eNOS. Cardiovasc Res 73(2):404\u2013413. S0008-6363(06)00356-7 [pii]. https:\/\/doi.org\/10.1016\/j.cardiores.2006.08.004","journal-title":"Cardiovasc Res"},{"issue":"2","key":"721_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/ptr.4977","volume":"28","author":"S Asgary","year":"2014","unstructured":"Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M (2014) Clinical evaluation of blood pressure lowering, endothelial function improving, hypolipidemic and anti-inflammatory effects of pomegranate juice in hypertensive subjects. Phytother Res 28(2):193\u2013199. https:\/\/doi.org\/10.1002\/ptr.4977","journal-title":"Phytother Res"},{"issue":"8","key":"721_CR11","doi-asserted-by":"crossref","first-page":"1535S","DOI":"10.1093\/jn\/138.8.1535S","volume":"138","author":"C Auger","year":"2008","unstructured":"Auger C, Mullen W, Hara Y, Crozier A (2008) Bioavailability of polyphenon E Flavan-3-Ols in humans with an ileostomy. J Nutr 138(8):1535S\u20131542S","journal-title":"J Nutr"},{"issue":"1","key":"721_CR12","first-page":"38","volume":"20","author":"C Auger","year":"2009","unstructured":"Auger C, Chataigneau T, Schini-Kerth VB (2009) Vascular protection by grape-derived polyphenols. Agro Food Ind Hi-Tech 20(1):38\u201340","journal-title":"Agro Food Ind Hi-Tech"},{"issue":"1","key":"721_CR13","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.bbrc.2010.01.112","volume":"393","author":"C Auger","year":"2010","unstructured":"Auger C, Kim JH, Chabert P, Chaabi M, Anselm E, Lanciaux X, Lobstein A, Schini-Kerth VB (2010a) The EGCg-induced redox-sensitive activation of endothelial nitric oxide synthase and relaxation are critically dependent on hydroxyl moieties. Biochem Biophys Res Commun 393(1):162\u2013167. https:\/\/doi.org\/10.1016\/j.bbrc.2010.01.112","journal-title":"Biochem Biophys Res Commun"},{"issue":"Suppl 2","key":"721_CR14","doi-asserted-by":"publisher","first-page":"S171","DOI":"10.1002\/mnfr.200900602","volume":"54","author":"C Auger","year":"2010","unstructured":"Auger C, Chaabi M, Anselm E, Lobstein A, Schini-Kerth VB (2010b) The red wine extract-induced activation of endothelial nitric oxide synthase is mediated by a great variety of polyphenolic compounds. Mol Nutr Food Res 54(Suppl 2):S171\u2013S183. https:\/\/doi.org\/10.1002\/mnfr.200900602","journal-title":"Mol Nutr Food Res"},{"issue":"5","key":"721_CR15","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1039\/c1fo10040h","volume":"2","author":"C Auger","year":"2011","unstructured":"Auger C, Kim JH, Trinh S, Chataigneau T, Popken AM, Schini-Kerth VB (2011) Fruit juice-Induced endothelium-dependent relaxations in isolated porcine coronary arteries: evaluation of different fruit juices and purees and optimization of a red fruit juice blend. Food Funct 2(5):245\u2013250. https:\/\/doi.org\/10.1039\/c1fo10040h","journal-title":"Food Funct"},{"issue":"1","key":"721_CR16","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1089\/jmf.2013.0183","volume":"18","author":"C Auger","year":"2015","unstructured":"Auger C, Pollet B, Arnold C, Marx C, Schini-Kerth VB (2015) Great heterogeneity of commercial fruit juices to induce endothelium-dependent relaxations in isolated porcine coronary arteries: role of the phenolic content and composition. J Med Food 18(1):128\u2013136","journal-title":"J Med Food"},{"issue":"1","key":"721_CR17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1097\/FJC.0000000000000382","volume":"68","author":"C Auger","year":"2016","unstructured":"Auger C, Said A, Nguyen PN, Chabert P, Idris-Khodja N, Schini-Kerth VB (2016) Potential of food and natural products to promote endothelial and vascular health. J Cardiovasc Pharmacol 68(1):11\u201318. https:\/\/doi.org\/10.1097\/FJC.0000000000000382","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"721_CR18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0021-9150(01)00412-9","volume":"158","author":"M Aviram","year":"2001","unstructured":"Aviram M, Dornfeld L (2001) Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis 158(1):195\u2013198","journal-title":"Atherosclerosis"},{"issue":"3","key":"721_CR19","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1016\/j.clnu.2003.10.002","volume":"23","author":"M Aviram","year":"2004","unstructured":"Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, Volkova N, Presser D, Attias J, Liker H, Hayek T (2004) Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr 23(3):423\u2013433. https:\/\/doi.org\/10.1016\/j.clnu.2003.10.002","journal-title":"Clin Nutr"},{"issue":"1","key":"721_CR20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2008.03.002","volume":"49","author":"T Baluchnejadmojarad","year":"2008","unstructured":"Baluchnejadmojarad T, Roghani M (2008) Chronic administration of Genistein improves aortic reactivity of Streptozotocin-diabetic rats: mode of action. Vascul Pharmacol 49(1):1\u20135","journal-title":"Vascul Pharmacol"},{"issue":"3","key":"721_CR21","doi-asserted-by":"publisher","first-page":"H942","DOI":"10.1152\/ajpheart.00724.2001","volume":"282","author":"I Bernatova","year":"2002","unstructured":"Bernatova I, Pechanova O, Babal P, Kysela S, Stvrtina S, Andriantsitohaina R (2002) Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension. Am J Physiol Heart Circ Physiol 282(3):H942\u2013H948. https:\/\/doi.org\/10.1152\/ajpheart.00724.2001","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"721_CR22","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/jch.12546","volume":"17","author":"C Bleakley","year":"2015","unstructured":"Bleakley C, Hamilton PK, Pumb R, Harbinson M, McVeigh GE (2015) Endothelial function in hypertension: victim or culprit? J Clin Hypertens (Greenwich) 17(8):651\u2013654","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"5","key":"721_CR23","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1097\/01.fjc.0000211762.06271.ce","volume":"47","author":"M Boban","year":"2006","unstructured":"Boban M, Modun D, Music I, Vukovic J, Brizic I, Salamunic I, Obad A, Palada I, Dujic Z (2006) Red wine Induced modulation of vascular function: separating the role of polyphenols, ethanol, and urates. J Cardiovasc Pharmacol 47(5):695\u2013701. https:\/\/doi.org\/10.1097\/01.fjc.0000211762.06271.ce","journal-title":"J Cardiovasc Pharmacol"},{"key":"721_CR24","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1159\/000358899","volume-title":"Interdisciplinary topics in gerontology and geriatrics","author":"J Campisi","year":"2014","unstructured":"Campisi J, Robert L (2014) Cell senescence: role in ageing and age-related diseases. In: Robert L, Fulop T (eds) Interdisciplinary topics in gerontology and geriatrics, vol 39. S. Karger AG, pp 45\u201361. https:\/\/doi.org\/10.1159\/000358899"},{"issue":"3","key":"721_CR25","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1017\/S0007114520004237","volume":"126","author":"RA Carnauba","year":"2021","unstructured":"Carnauba RA, Hassimotto NMA, Lajolo FM (2021) Estimated dietary polyphenol intake and major food sources of the Brazilian population. Br J Nutr 126(3):441\u2013448. https:\/\/doi.org\/10.1017\/S0007114520004237","journal-title":"Br J Nutr"},{"issue":"1","key":"721_CR26","doi-asserted-by":"publisher","first-page":"e8554","DOI":"10.1371\/journal.pone.0008554","volume":"5","author":"M Chalopin","year":"2010","unstructured":"Chalopin M, Tesse A, Martinez MC, Rognan D, Arnal JF, Andriantsitohaina R (2010) Estrogen receptor alpha as a key target of red wine polyphenols action on the endothelium. PLoS One 5(1):e8554. https:\/\/doi.org\/10.1371\/journal.pone.0008554","journal-title":"PLoS One"},{"issue":"6","key":"721_CR27","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1097\/FJC.0b013e3181760fa5","volume":"51","author":"S-L Chan","year":"2008","unstructured":"Chan S-L, Capdeville-Atkinson C, Atkinson J (2008a) Red wine polyphenols improve endothelium-dependent dilation in rat cerebral arterioles. J Cardiovasc Pharmacol 51(6):553\u2013558. https:\/\/doi.org\/10.1097\/FJC.0b013e3181760fa5","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"721_CR28","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1097\/FJC.0b013e318163a946","volume":"51","author":"SL Chan","year":"2008","unstructured":"Chan SL, Tabellion A, Bagrel D, Perrin-Sarrado C, Capdeville-Atkinson C, Atkinson J (2008b) Impact of chronic treatment with red wine polyphenols (RWP) on cerebral arterioles in the spontaneous hypertensive rat. J Cardiovasc Pharmacol 51(3):304\u2013310. https:\/\/doi.org\/10.1097\/FJC.0b013e318163a946","journal-title":"J Cardiovasc Pharmacol"},{"key":"721_CR29","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/978-3-319-23246-1_5","volume-title":"Advances in geroscience","author":"YA Chiao","year":"2016","unstructured":"Chiao YA, Lakatta E, Ungvari Z, Dai D-F, Rabinovitch P (2016) Cardiovascular disease and ageing. In: Sierra F, Kohanski R (eds) Advances in geroscience. Springer, Cham, pp 121\u2013160. https:\/\/doi.org\/10.1007\/978-3-319-23246-1_5"},{"issue":"8","key":"721_CR30","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1161\/CIRCRESAHA.112.275636","volume":"111","author":"G Chiva-Blanch","year":"2012","unstructured":"Chiva-Blanch G, Urpi-Sarda M, Ros E, Arranz S, Valderas-Martinez P, Casas R, Sacanella E, Llorach R, Lamuela-Raventos RM, Andres-Lacueva C, Estruch R (2012) Dealcoholized red wine decreases systolic and diastolic blood pressure and increases plasma nitric oxide: short communication. Circ Res 111(8):1065\u20131068. https:\/\/doi.org\/10.1161\/CIRCRESAHA.112.275636","journal-title":"Circ Res"},{"issue":"3","key":"721_CR31","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1093\/alcalc\/agt007","volume":"48","author":"G Chiva-Blanch","year":"2013","unstructured":"Chiva-Blanch G, Arranz S, Lamuela-Raventos RM, Estruch R (2013) Effects of wine, alcohol and polyphenols on cardiovascular disease risk factors: evidences from human studies. Alcohol Alcohol 48(3):270\u2013277. https:\/\/doi.org\/10.1093\/alcalc\/agt007","journal-title":"Alcohol Alcohol"},{"issue":"5","key":"721_CR32","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0002-9149(01)01738-6","volume":"88","author":"EJ Chou","year":"2001","unstructured":"Chou EJ, Keevil JG, Aeschlimann S, Wiebe DA, Folts JD, Stein JH (2001) Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart Disease. Am J Cardiol 88(5):553\u2013555","journal-title":"Am J Cardiol"},{"issue":"1","key":"721_CR33","first-page":"53","volume":"10","author":"HH Chow","year":"2001","unstructured":"Chow HH, Cai Y, Alberts DS, Hakim I, Dorr R, Shahi F, Crowell JA, Yang CS, Hara Y (2001) Phase I pharmacokinetic study of tea polyphenols following single-dose administration of Epigallocatechin Gallate and Polyphenon E. Cancer Epidemiol Biomarkers Prev 10(1):53\u201358","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"14","key":"721_CR34","doi-asserted-by":"publisher","first-page":"6156","DOI":"10.1021\/jf804045b","volume":"57","author":"E Cienfuegos-Jovellanos","year":"2009","unstructured":"Cienfuegos-Jovellanos E, Quinones Mdel M, Muguerza B, Moulay L, Miguel M, Aleixandre A (2009) Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans. J Agric Food Chem 57(14):6156\u20136162. https:\/\/doi.org\/10.1021\/jf804045b","journal-title":"J Agric Food Chem"},{"key":"721_CR35","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","volume":"5","author":"J-P Copp\u00e9","year":"2010","unstructured":"Copp\u00e9 J-P, Desprez P-Y, Krtolica A, Campisi J (2010) The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu Rev Pathol 5:99\u2013118. https:\/\/doi.org\/10.1146\/annurev-pathol-121808-102144","journal-title":"Annu Rev Pathol"},{"key":"721_CR36","first-page":"27","volume-title":"Plants: diet and health","author":"A Crozier","year":"2008","unstructured":"Crozier A (2008) Classification and biosynthesis of secondary plant products: an overview. In: Plants: diet and health. Blackwell Science Ltd, pp 27\u201348"},{"issue":"8","key":"721_CR37","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1039\/b802662a","volume":"26","author":"A Crozier","year":"2009","unstructured":"Crozier A, Jaganath IB, Clifford MN (2009) Dietary phenolics: chemistry, bioavailability and effects on health. Nat Prod Rep 26(8):1001\u20131043. https:\/\/doi.org\/10.1039\/b802662a","journal-title":"Nat Prod Rep"},{"issue":"12","key":"721_CR38","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1248\/bpb.b12-00598","volume":"35","author":"X Cui","year":"2012","unstructured":"Cui X, Liu X, Feng H, Zhao S, Gao H (2012) Grape seed proanthocyanidin extracts enhance endothelial nitric oxide synthase expression through 5\u2019-AMP activated protein kinase\/Surtuin 1-Krupple like factor 2 pathway and modulate blood pressure in Ouabain Induced hypertensive rats. Biol Pharm Bull 35(12):2192\u20132197","journal-title":"Biol Pharm Bull"},{"issue":"11","key":"721_CR39","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.3390\/molecules25112601","volume":"25","author":"R D\u2019Agostino","year":"2020","unstructured":"D\u2019Agostino R, Barberio L, Gatto M, Muzzalupo I, Mandal\u00e0 M (2020) Extra virgin olive oil phenols dilate the rat mesenteric artery by activation of BKCa2+ channels in smooth muscle cells. Molecules 25(11):2601. https:\/\/doi.org\/10.3390\/molecules25112601","journal-title":"Molecules"},{"key":"721_CR40","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.atherosclerosis.2017.06.028","volume":"263","author":"M D\u2019Apolito","year":"2017","unstructured":"D\u2019Apolito M, Colia AL, Lasalvia M, Capozzi V, Falcone MP, Pettoello-Mantovani M, Brownlee M, Maffione AB, Giardino I (2017) Urea-induced ROS accelerate senescence in endothelial progenitor cells. Atherosclerosis 263:127\u2013136. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2017.06.028","journal-title":"Atherosclerosis"},{"issue":"2","key":"721_CR41","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.bbrc.2010.12.060","volume":"404","author":"S Dal-Ros","year":"2011","unstructured":"Dal-Ros S, Zoll J, Lang AL, Auger C, Keller N, Bronner C, Geny B, Schini-Kerth VB (2011) Chronic intake of red wine polyphenols by young rats prevents ageing-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. Biochem Biophys Res Commun 404(2):743\u2013749","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"721_CR42","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.bbrc.2012.02.031","volume":"419","author":"S Dal-Ros","year":"2012","unstructured":"Dal-Ros S, Bronner C, Auger C, Schini-Kerth VB (2012) Red wine polyphenols improve an established ageing-related endothelial dysfunction in the mesenteric artery of middle-aged rats: role of oxidative stress. Biochem Biophys Res Commun 419(2):381\u2013387. https:\/\/doi.org\/10.1016\/j.bbrc.2012.02.031","journal-title":"Biochem Biophys Res Commun"},{"issue":"8","key":"721_CR43","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1212\/01.wnl.0000180600.09719.53","volume":"65","author":"L Dauchet","year":"2005","unstructured":"Dauchet L, Amouyel P, Dallongeville J (2005) Fruit and vegetable consumption and risk of stroke: a meta-analysis of cohort studies. Neurology 65(8):1193\u20131197","journal-title":"Neurology"},{"issue":"10","key":"721_CR44","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/jn\/136.10.2588","volume":"136","author":"L Dauchet","year":"2006","unstructured":"Dauchet L, Amouyel P, Hercberg S, Dallongeville J (2006) Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr 136(10):2588\u20132593","journal-title":"J Nutr"},{"issue":"6","key":"721_CR45","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/ajcn\/85.6.1650","volume":"85","author":"L Dauchet","year":"2007","unstructured":"Dauchet L, Kesse-Guyot E, Czernichow S, Bertrais S, Estaquio C, Peneau S, Vergnaud AC, Chat-Yung S, Castetbon K, Deschamps V, Brindel P, Hercberg S (2007) Dietary patterns and blood pressure change over 5-y follow-up in the SU.VI.MAX cohort. Am J Clin Nutr 85(6):1650\u20131656","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"721_CR46","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/01.fjc.0000133060.10597.3c","volume":"44","author":"RS de Moura","year":"2004","unstructured":"de Moura RS, Miranda DZ, Pinto AC, Sicca RF, Souza MA, Rubenich LM, Carvalho LC, Rangel BM, Tano T, Madeira SV, Resende AC (2004) Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. J Cardiovasc Pharmacol 44(3):302\u2013309","journal-title":"J Cardiovasc Pharmacol"},{"issue":"1","key":"721_CR47","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.niox.2007.04.005","volume":"17","author":"F de Nigris","year":"2007","unstructured":"de Nigris F, Balestrieri ML, Williams-Ignarro S, D\u2019Armiento FP, Fiorito C, Ignarro LJ, Napoli C (2007) The influence of pomegranate fruit extract in comparison to regular pomegranate juice and seed oil on nitric oxide and arterial function in obese Zucker rats. Nitric Oxide 17(1):50\u201354. https:\/\/doi.org\/10.1016\/j.niox.2007.04.005","journal-title":"Nitric Oxide"},{"issue":"10","key":"721_CR48","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1161\/CIRCULATIONAHA.106.652859","volume":"115","author":"JE Deanfield","year":"2007","unstructured":"Deanfield JE, Halcox JP, Rabelink TJ (2007) Endothelial function and dysfunction: testing and clinical relevance. Circulation 115(10):1285\u20131295. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.652859","journal-title":"Circulation"},{"key":"721_CR49","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1089\/ars.2012.4581","volume":"18","author":"D Del Rio","year":"2012","unstructured":"Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A (2012) Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal 18:1818. https:\/\/doi.org\/10.1089\/ars.2012.4581","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"721_CR50","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejim.2011.07.014","volume":"23","author":"A Di Castelnuovo","year":"2012","unstructured":"Di Castelnuovo A, Di Giuseppe R, Iacoviello L, De Gaetano G (2012) Consumption of cocoa, tea and coffee and risk of cardiovascular disease. Eur J Intern Med 23(1):15\u201325. https:\/\/doi.org\/10.1016\/j.ejim.2011.07.014","journal-title":"Eur J Intern Med"},{"key":"721_CR51","doi-asserted-by":"crossref","first-page":"934","DOI":"10.3945\/ajcn.110.004242","volume":"93","author":"MM Dohadwala","year":"2011","unstructured":"Dohadwala MM, Hamburg NM, Holbrook M, Kim BH, Duess MA, Levit A, Titas M, Chung WB, Vincent FB, Caiano TL, Frame AA, Keaney JF, Vita JA (2011) Effects of concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin Nutr 93:934\u2013940","journal-title":"Am J Clin Nutr"},{"issue":"7","key":"721_CR52","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1161\/CIRCRESAHA.118.312563","volume":"123","author":"AJ Donato","year":"2018","unstructured":"Donato AJ, Machin DR, Lesniewski LA (2018) Mechanisms of dysfunction in the Ageing vasculature and role in age-related disease. Circ Res 123(7):825\u2013848. https:\/\/doi.org\/10.1161\/CIRCRESAHA.118.312563","journal-title":"Circ Res"},{"issue":"1","key":"721_CR53","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1159\/000354847","volume":"3","author":"DW Droste","year":"2013","unstructured":"Droste DW, Iliescu C, Vaillant M, Gantenbein M, De Bremaeker N, Lieunard C, Velez T, Meyer M, Guth T, Kuemmerle A, Chioti A (2013) A daily glass of red wine and lifestyle changes do not affect arterial blood pressure and heart rate in patients with carotid arteriosclerosis after 4 and 20 weeks. Cerebrovasc Extra 3(1):121\u2013129","journal-title":"Cerebrovasc Extra"},{"issue":"14","key":"721_CR54","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1056\/NEJMoa1501451","volume":"374","author":"H Du","year":"2016","unstructured":"Du H, Li L, Bennett D, Guo Y, Key TJ, Bian Z, Sherliker P, Gao H, Chen Y, Yang L, Chen J, Wang S, Du R, Su H, Collins R, Peto R, Chen Z (2016) Fresh fruit consumption and major cardiovascular disease in China. N Engl J Med 374(14):1332\u20131343. https:\/\/doi.org\/10.1056\/NEJMoa1501451","journal-title":"N Engl J Med"},{"issue":"1","key":"721_CR55","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1038\/sj.bjp.0704064","volume":"133","author":"J Duarte","year":"2001","unstructured":"Duarte J, Perez-Palencia R, Vargas F, Ocete MA, Perez-Vizcaino F, Zarzuelo A, Tamargo J (2001) Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br J Pharmacol 133(1):117\u2013124. https:\/\/doi.org\/10.1038\/sj.bjp.0704064","journal-title":"Br J Pharmacol"},{"issue":"9","key":"721_CR56","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1097\/00004872-200209000-00031","volume":"20","author":"J Duarte","year":"2002","unstructured":"Duarte J, Jimenez R, O\u2019Valle F, Galisteo M, Perez-Palencia R, Vargas F, Perez-Vizcaino F, Zarzuelo A, Tamargo J (2002) Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats. J Hypertens 20(9):1843\u20131854","journal-title":"J Hypertens"},{"issue":"2","key":"721_CR57","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.CIR.104.2.151","volume":"104","author":"SJ Duffy","year":"2001","unstructured":"Duffy SJ, Keaney JF, Holbrook M, Gokce N, Swerdloff PL, Frei B, Vita JA (2001) Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation 104(2):151\u2013156","journal-title":"Circulation"},{"issue":"3","key":"721_CR58","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1080\/07315724.2004.10719361","volume":"23","author":"MB Engler","year":"2004","unstructured":"Engler MB, Engler MM, Chen CY, Malloy MJ, Browne A, Chiu EY, Kwak HK, Milbury P, Paul SM, Blumberg J, Mietus-Snyder ML (2004) Flavonoid-rich dark chocolate improves endothelial function and increases plasma Epicatechin concentrations in healthy adults. J Am Coll Nutr 23(3):197\u2013204","journal-title":"J Am Coll Nutr"},{"issue":"2","key":"721_CR59","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/ajcn\/87.2.323","volume":"87","author":"I Erlund","year":"2008","unstructured":"Erlund I, Koli R, Alfthan G, Marniemi J, Puukka P, Mustonen P, Mattila P, Jula A (2008) Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 87(2):323\u2013331","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"721_CR60","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1152\/japplphysiol.91353.2008","volume":"106","author":"JD Erusalimsky","year":"2009","unstructured":"Erusalimsky JD (2009) Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 106(1):326\u2013332. https:\/\/doi.org\/10.1152\/japplphysiol.91353.2008","journal-title":"J Appl Physiol"},{"issue":"1","key":"721_CR61","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1093\/ajcn\/88.1.58","volume":"88","author":"Z Faridi","year":"2008","unstructured":"Faridi Z, Njike VY, Dutta S, Ali A, Katz DL (2008) Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr 88(1):58\u201363. 88\/1\/58 [pii]","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"721_CR62","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1042\/CS20090096","volume":"117","author":"M Feletou","year":"2009","unstructured":"Feletou M, Vanhoutte PM (2009) EDHF: an update. Clin Sci 117(4):139\u2013155. https:\/\/doi.org\/10.1042\/CS20090096","journal-title":"Clin Sci"},{"issue":"2 Pt 2","key":"721_CR63","first-page":"H774","volume":"265","author":"DF Fitzpatrick","year":"1993","unstructured":"Fitzpatrick DF, Hirschfield SL, Coffey RG (1993) Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 265(2 Pt 2):H774\u2013H778","journal-title":"Am J Physiol"},{"issue":"1","key":"721_CR64","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00005344-199507000-00015","volume":"26","author":"DF Fitzpatrick","year":"1995","unstructured":"Fitzpatrick DF, Hirschfield SL, Ricci T, Jantzen P, Coffey RG (1995) Endothelium-dependent vasorelaxation caused by various plant extracts. J Cardiovasc Pharmacol 26(1):90\u201395","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"721_CR65","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.3390\/ijms24032057","volume":"24","author":"S Franceschelli","year":"2023","unstructured":"Franceschelli S, De Cecco F, Pesce M, Ripari P, Guagnano MT, Nuevo AB, Grilli A, Sancilio S, Speranza L (2023) Hydroxytyrosol reduces foam cell formation and endothelial inflammation regulating the PPAR\u03b3\/LXR\u03b1\/ABCA1 pathway. Int J Mol Sci 24(3):2057. https:\/\/doi.org\/10.3390\/ijms24032057","journal-title":"Int J Mol Sci"},{"issue":"5789","key":"721_CR66","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","volume":"288","author":"RF Furchgott","year":"1980","unstructured":"Furchgott RF, Zawadzki JV (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288(5789):373\u2013376","journal-title":"Nature"},{"issue":"4","key":"721_CR67","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1055\/s-2004-818945","volume":"70","author":"M Galisteo","year":"2004","unstructured":"Galisteo M, Garcia-Saura MF, Jimenez R, Villar IC, Wangensteen R, Zarzuelo A, Vargas F, Duarte J (2004) Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with Verapamil. Planta Med 70(4):334\u2013341. https:\/\/doi.org\/10.1055\/s-2004-818945","journal-title":"Planta Med"},{"issue":"8","key":"721_CR68","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1002\/iub.1185","volume":"65","author":"M Galleano","year":"2013","unstructured":"Galleano M, Bernatova I, Puzserova A, Balis P, Sestakova N, Pechanova O, Fraga CG (2013) (\u2212)-Epicatechin reduces blood pressure and improves vasorelaxation in spontaneously hypertensive rats by NO-mediated mechanism. IUBMB Life 65(8):710\u2013715","journal-title":"IUBMB Life"},{"issue":"1\u20132","key":"721_CR69","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11010-005-4503-0","volume":"270","author":"MF Garcia-Saura","year":"2005","unstructured":"Garcia-Saura MF, Galisteo M, Villar IC, Bermejo A, Zarzuelo A, Vargas F, Duarte J (2005) Effects of chronic quercetin treatment in experimental renovascular hypertension. Mol Cell Biochem 270(1\u20132):147\u2013155","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"721_CR70","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.freeradbiomed.2011.09.015","volume":"52","author":"M Gomez-Guzman","year":"2012","unstructured":"Gomez-Guzman M, Jimenez R, Sanchez M, Zarzuelo MJ, Galindo P, Quintela AM, Lopez-Sepulveda R, Romero M, Tamargo J, Vargas F, Perez-Vizcaino F, Duarte J (2012) Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and Endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension. Free Radic Biol Med 52(1):70\u201379. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.09.015","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"721_CR71","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/HJH.0b013e328326066c","volume":"27","author":"D Grassi","year":"2009","unstructured":"Grassi D, Mulder TP, Draijer R, Desideri G, Molhuizen HO, Ferri C (2009) Black tea consumption dose-dependently improves flow-mediated dilation in healthy males. J Hypertens 27(4):774\u2013781","journal-title":"J Hypertens"},{"issue":"2","key":"721_CR72","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1097\/HJH.0000000000000412","volume":"33","author":"D Grassi","year":"2015","unstructured":"Grassi D, Desideri G, Necozione S, di Giosia P, Barnabei R, Allegaert L, Bernaert H, Ferri C (2015) Cocoa consumption dose-dependently improves flow-mediated dilation and arterial stiffness decreasing blood pressure in healthy individuals. J Hypertens 33(2):294\u2013303","journal-title":"J Hypertens"},{"issue":"7","key":"721_CR73","doi-asserted-by":"crossref","first-page":"e103247","DOI":"10.1371\/journal.pone.0103247","volume":"9","author":"A Greyling","year":"2014","unstructured":"Greyling A, Ras RT, Zock PL, Lorenz M, Hopman MT, Thijssen DH, Draijer R (2014) The effect of black tea on blood pressure: a systematic review with meta-analysis of randomized controlled trials. PLoS One 9(7):e103247","journal-title":"PLoS One"},{"issue":"17","key":"721_CR74","doi-asserted-by":"publisher","first-page":"2034","DOI":"10.1161\/01.CIR.0000093661.90582.c4","volume":"108","author":"KK Griendling","year":"2003","unstructured":"Griendling KK, FitzGerald GA (2003) Oxidative stress and cardiovascular injury: part II: animal and human studies. Circulation 108(17):2034\u20132040. https:\/\/doi.org\/10.1161\/01.CIR.0000093661.90582.c4","journal-title":"Circulation"},{"issue":"5","key":"721_CR75","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1161\/01.RES.86.5.494","volume":"86","author":"KK Griendling","year":"2000","unstructured":"Griendling KK, Sorescu D, Ushio-Fukai M (2000) NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 86(5):494\u2013501","journal-title":"Circ Res"},{"issue":"2","key":"721_CR76","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-277X.2009.01021.x","volume":"23","author":"SM Hampton","year":"2010","unstructured":"Hampton SM, Isherwood C, Kirkpatrick VJ, Lynne-Smith AC, Griffin BA (2010) The influence of alcohol consumed with a meal on endothelial function in healthy individuals. J Hum Nutr Diet 23(2):120\u2013125","journal-title":"J Hum Nutr Diet"},{"issue":"12","key":"721_CR77","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1016\/S0002-9149(01)02137-3","volume":"88","author":"M Hashimoto","year":"2001","unstructured":"Hashimoto M, Kim S, Eto M, Iijima K, Ako J, Yoshizumi M, Akishita M, Kondo K, Itakura H, Hosoda K, Toba K, Ouchi Y (2001) Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery. Am J Cardiol 88(12):1457\u20131460. A9","journal-title":"Am J Cardiol"},{"issue":"3","key":"721_CR78","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/0014-4827(65)90211-9","volume":"37","author":"L Hayflick","year":"1965","unstructured":"Hayflick L (1965) The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37(3):614\u2013636. https:\/\/doi.org\/10.1016\/0014-4827(65)90211-9","journal-title":"Exp Cell Res"},{"issue":"9507","key":"721_CR79","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1016\/S0140-6736(06)68069-0","volume":"367","author":"FJ He","year":"2006","unstructured":"He FJ, Nowson CA, MacGregor GA (2006) Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet 367(9507):320\u2013326. https:\/\/doi.org\/10.1016\/S0140-6736(06)68069-0","journal-title":"Lancet"},{"issue":"9","key":"721_CR80","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/sj.jhh.1002212","volume":"21","author":"FJ He","year":"2007","unstructured":"He FJ, Nowson CA, Lucas M, MacGregor GA (2007) Increased consumption of fruit and vegetables is related to a reduced risk of coronary heart disease: meta-analysis of cohort studies. J Hum Hypertens 21(9):717\u2013728","journal-title":"J Hum Hypertens"},{"issue":"19","key":"721_CR81","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1093\/eurheartj\/ehi333","volume":"26","author":"AG Herman","year":"2005","unstructured":"Herman AG, Moncada S (2005) Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis. Eur Heart J 26(19):1945\u20131955","journal-title":"Eur Heart J"},{"issue":"2","key":"721_CR82","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1042\/cs1020195","volume":"102","author":"JM Hodgson","year":"2002","unstructured":"Hodgson JM, Puddey IB, Burke V, Watts GF, Beilin LJ (2002) Regular ingestion of black tea improves brachial artery vasodilator function. Clin Sci 102(2):195\u2013201","journal-title":"Clin Sci"},{"issue":"2","key":"721_CR83","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archinte.172.2.186","volume":"172","author":"JM Hodgson","year":"2012","unstructured":"Hodgson JM, Puddey IB, Woodman RJ et al (2012) Effects of black tea on blood pressure: a randomized controlled trial. Arch Intern Med 172(2):186\u2013188","journal-title":"Arch Intern Med"},{"issue":"11","key":"721_CR84","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1016\/j.jand.2020.06.016","volume":"120","author":"Q Huang","year":"2020","unstructured":"Huang Q, Braffett BH, Simmens SJ, Young HA, Ogden CL (2020) Dietary polyphenol intake in US adults and 10-year trends: 2007-2016. J Acad Nutr Diet 120(11):1821\u20131833. https:\/\/doi.org\/10.1016\/j.jand.2020.06.016","journal-title":"J Acad Nutr Diet"},{"issue":"12","key":"721_CR85","doi-asserted-by":"publisher","first-page":"932","DOI":"10.18632\/ageing.100520","volume":"4","author":"S Hubackova","year":"2012","unstructured":"Hubackova S, Krejcikova K, Bartek J, Hodny Z (2012) IL1- and TGF\u03b2-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine \u2018Bystander Senescence\u2019. Ageing 4(12):932\u2013951. https:\/\/doi.org\/10.18632\/ageing.100520","journal-title":"Ageing"},{"issue":"2","key":"721_CR86","doi-asserted-by":"publisher","first-page":"e32039","DOI":"10.1371\/journal.pone.0032039","volume":"7","author":"N Idris Khodja","year":"2012","unstructured":"Idris Khodja N, Chataigneau T, Auger C, Schini-Kerth VB (2012) Grape-derived polyphenols improve ageing-related endothelial dysfunction in rat mesenteric artery: role of oxidative stress and the angiotensin system. PLoS One 7(2):e32039. https:\/\/doi.org\/10.1371\/journal.pone.0032039","journal-title":"PLoS One"},{"issue":"17","key":"721_CR87","doi-asserted-by":"publisher","first-page":"6403","DOI":"10.3390\/molecules28176403","volume":"28","author":"I Iqbal","year":"2023","unstructured":"Iqbal I, Wilairatana P, Saqib F, Nasir B, Wahid M, Latif MF, Iqbal A, Naz R, Mubarak MS (2023) Plant polyphenols and their potential benefits on cardiovascular health: a review. Molecules 28(17):6403. https:\/\/doi.org\/10.3390\/molecules28176403","journal-title":"Molecules"},{"issue":"7","key":"721_CR88","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1016\/j.freeradbiomed.2011.06.017","volume":"51","author":"A Ishisaka","year":"2011","unstructured":"Ishisaka A, Ichikawa S, Sakakibara H, Piskula MK, Nakamura T, Kato Y, Ito M, Miyamoto K, Tsuji A, Kawai Y, Terao J (2011) Accumulation of orally administered quercetin in brain tissue and its antioxidative effects in rats. Free Radic Biol Med 51(7):1329\u20131336. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2011.06.017","journal-title":"Free Radic Biol Med"},{"issue":"3","key":"721_CR89","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/j.freeradbiomed.2007.05.007","volume":"43","author":"R Jimenez","year":"2007","unstructured":"Jimenez R, Lopez-Sepulveda R, Kadmiri M, Romero M, Vera R, Sanchez M, Vargas F, O\u2019Valle F, Zarzuelo A, Duenas M, Santos-Buelga C, Duarte J (2007) Polyphenols restore endothelial function in DOCA-salt hypertension: role of Endothelin-1 and NADPH oxidase. Free Radic Biol Med 43(3):462\u2013473. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2007.05.007","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"721_CR90","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1017\/S0007114507838992","volume":"99","author":"N Jochmann","year":"2008","unstructured":"Jochmann N, Lorenz M, Krosigk A, Martus P, Bohm V, Baumann G, Stangl K, Stangl V (2008) The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Br J Nutr 99(4):863\u2013868. https:\/\/doi.org\/10.1017\/S0007114507838992","journal-title":"Br J Nutr"},{"issue":"3","key":"721_CR91","doi-asserted-by":"publisher","first-page":"816","DOI":"10.3390\/ijms19030816","volume":"19","author":"H Joo","year":"2018","unstructured":"Joo H, Choi S, Lee Y, Lee E, Park M, Park K, Kim C-S, Lim Y, Park J-T, Jeon B (2018) Anthocyanin-rich extract from red Chinese cabbage alleviates vascular inflammation in endothelial cells and Apo E\u2212\/\u2212 mice. Int J Mol Sci 19(3):816. https:\/\/doi.org\/10.3390\/ijms19030816","journal-title":"Int J Mol Sci"},{"issue":"2\u20133","key":"721_CR92","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.vph.2009.05.002","volume":"51","author":"MO Kane","year":"2009","unstructured":"Kane MO, Anselm E, Rattmann YD, Auger C, Schini-Kerth VB (2009) Role of gender and estrogen receptors in the rat aorta endothelium-dependent relaxation to red wine polyphenols. Vascul Pharmacol 51(2\u20133):140\u2013146. https:\/\/doi.org\/10.1016\/j.vph.2009.05.002","journal-title":"Vascul Pharmacol"},{"issue":"5","key":"721_CR93","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1007\/s00424-009-0759-7","volume":"459","author":"MO Kane","year":"2010","unstructured":"Kane MO, Etienne-Selloum N, Madeira SV, Sarr M, Walter A, Dal-Ros S, Schott C, Chataigneau T, Schini-Kerth VB (2010) Endothelium-derived contracting factors mediate the Ang II-Induced endothelial dysfunction in the rat aorta: preventive effect of red wine polyphenols. Pflugers Arch 459(5):671\u2013679. https:\/\/doi.org\/10.1007\/s00424-009-0759-7","journal-title":"Pflugers Arch"},{"issue":"4","key":"721_CR94","first-page":"369","volume":"59","author":"MO Kane","year":"2015","unstructured":"Kane MO, Sene M, Anselm E, Dal S, Schini-Kerth VB, Augier C (2015) Role of AMP-activated protein kinase in NO- and EDHF-mediated endothelium-dependent relaxations to red wine polyphenols. Indian J Physiol Pharmacol 59(4):369\u2013379","journal-title":"Indian J Physiol Pharmacol"},{"issue":"2","key":"721_CR95","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.abb.2008.01.022","volume":"476","author":"Y Kawai","year":"2008","unstructured":"Kawai Y, Ishisaka A, Saito S, Uchida K, Shibata N, Kobayashi M, Fukuchi Y, Naito M, Terao J (2008a) Immunochemical detection of flavonoid glycosides: development, specificity, and application of novel monoclonal antibodies. Arch Biochem Biophys 476(2):124\u2013132. https:\/\/doi.org\/10.1016\/j.abb.2008.01.022","journal-title":"Arch Biochem Biophys"},{"issue":"14","key":"721_CR96","doi-asserted-by":"publisher","first-page":"9424","DOI":"10.1074\/jbc.M706571200","volume":"283","author":"Y Kawai","year":"2008","unstructured":"Kawai Y, Nishikawa T, Shiba Y, Saito S, Murota K, Shibata N, Kobayashi M, Kanayama M, Uchida K, Terao J (2008b) Macrophage as a target of quercetin glucuronides in human atherosclerotic arteries: implication in the anti-atherosclerotic mechanism of dietary flavonoids. J Biol Chem 283(14):9424\u20139434. https:\/\/doi.org\/10.1074\/jbc.M706571200","journal-title":"J Biol Chem"},{"issue":"3","key":"721_CR97","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1016\/j.bbrc.2008.07.086","volume":"374","author":"Y Kawai","year":"2008","unstructured":"Kawai Y, Tanaka H, Murota K, Naito M, Terao J (2008c) (\u2212)-Epicatechin Gallate accumulates in foamy macrophages in human atherosclerotic aorta: implication in the anti-atherosclerotic actions of tea Catechins. Biochem Biophys Res Commun 374(3):527\u2013532. https:\/\/doi.org\/10.1016\/j.bbrc.2008.07.086","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"721_CR98","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1093\/gerona\/glv213","volume":"71","author":"S Khemais-Benkhiat","year":"2016","unstructured":"Khemais-Benkhiat S, Idris-Khodja N, Ribeiro TP, Silva GC, Abbas M, Kheloufi M, Lee J-O, Toti F, Auger C, Schini-Kerth VB (2016) The redox-sensitive induction of the local angiotensin system promotes both premature and replicative endothelial senescence: preventive effect of a standardized crataegus extract. J Gerontol A Biol Sci Med Sci 71(12):1581\u20131590. https:\/\/doi.org\/10.1093\/gerona\/glv213","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"721_CR99","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1111\/jcmm.14233","volume":"24","author":"S Khemais-Benkhiat","year":"2020","unstructured":"Khemais-Benkhiat S, Belcastro E, Idris-Khodja N, Park S-H, Amoura L, Abbas M, Auger C, Kessler L, Mayoux E, Toti F, Schini-Kerth VB (2020) Angiotensin II-Induced redox-sensitive SGLT1 and 2 expression promotes high glucose-Induced endothelial cell senescence. J Cell Mol Med 24(3):2109\u20132122. https:\/\/doi.org\/10.1111\/jcmm.14233","journal-title":"J Cell Mol Med"},{"issue":"1","key":"721_CR100","doi-asserted-by":"publisher","first-page":"47","DOI":"10.5483\/BMBRep.2019.52.1.293","volume":"52","author":"E-C Kim","year":"2019","unstructured":"Kim E-C, Kim J-R (2019) Senotherapeutics: emerging strategy for healthy ageing and age-related disease. BMB Rep 52(1):47\u201355. https:\/\/doi.org\/10.5483\/BMBRep.2019.52.1.293","journal-title":"BMB Rep"},{"issue":"18","key":"721_CR101","doi-asserted-by":"publisher","first-page":"13736","DOI":"10.1074\/jbc.M609725200","volume":"282","author":"JA Kim","year":"2007","unstructured":"Kim JA, Formoso G, Li Y, Potenza MA, Marasciulo FL, Montagnani M, Quon MJ (2007) Epigallocatechin Gallate, a green tea polyphenol, mediates NO-dependent vasodilation using signaling pathways in vascular endothelium requiring reactive oxygen species and Fyn. J Biol Chem 282(18):13736\u201313745. https:\/\/doi.org\/10.1074\/jbc.M609725200","journal-title":"J Biol Chem"},{"key":"721_CR102","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.niox.2013.08.002","volume":"35","author":"JH Kim","year":"2013","unstructured":"Kim JH, Auger C, Kurita I, Anselm E, Rivoarilala LO, Lee HJ, Lee KW, Schini-Kerth VB (2013) Aronia melanocarpa juice, a rich source of polyphenols, induces endothelium-dependent relaxations in porcine coronary arteries via the redox-sensitive activation of endothelial nitric oxide synthase. Nitric Oxide 35:54\u201364. https:\/\/doi.org\/10.1016\/j.niox.2013.08.002","journal-title":"Nitric Oxide"},{"issue":"2","key":"721_CR103","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1016\/j.advnut.2023.01.002","volume":"14","author":"T Kiyimba","year":"2023","unstructured":"Kiyimba T, Yiga P, Bamuwamye M, Ogwok P, Van der Schueren B, Matthys C (2023) Efficacy of dietary polyphenols from whole foods and purified food polyphenol extracts in optimizing cardiometabolic health: a meta-analysis of randomized controlled trials. Adv Nutr 14(2):270\u2013282. https:\/\/doi.org\/10.1016\/j.advnut.2023.01.002","journal-title":"Adv Nutr"},{"issue":"6","key":"721_CR104","first-page":"596","volume":"12","author":"J Lekakis","year":"2005","unstructured":"Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, Skaltsounis AL, Kremastinos DT (2005) Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 12(6):596\u2013600","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"721_CR105","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3389\/fphar.2016.00529","volume":"7","author":"D Leonetti","year":"2017","unstructured":"Leonetti D, Soleti R, Clere N, Vergori L, Jacques C, Duluc L, Dourguia C, Mart\u00ednez MC, Andriantsitohaina R (2017) Estrogen receptor \u03b1 participates to the beneficial effect of red wine polyphenols in a mouse model of obesity-related disorders. Front Pharmacol 7:7. https:\/\/doi.org\/10.3389\/fphar.2016.00529","journal-title":"Front Pharmacol"},{"issue":"3","key":"721_CR106","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1161\/01.CIR.0000153339.27064.14","volume":"111","author":"A Lerman","year":"2005","unstructured":"Lerman A, Zeiher AM (2005) Endothelial function: cardiac events. Circulation 111(3):363\u2013368","journal-title":"Circulation"},{"key":"721_CR107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.mad.2019.05.001","volume":"181","author":"W Li","year":"2019","unstructured":"Li W, Qin L, Feng R, Hu G, Sun H, He Y, Zhang R (2019) Emerging senolytic agents derived from natural products. Mech Ageing Dev 181:1\u20136. https:\/\/doi.org\/10.1016\/j.mad.2019.05.001","journal-title":"Mech Ageing Dev"},{"issue":"4","key":"721_CR108","doi-asserted-by":"publisher","first-page":"3711","DOI":"10.3892\/mmr.2016.5699","volume":"14","author":"Y Liang","year":"2016","unstructured":"Liang Y, Wang J, Gao H, Wang Q, Zhang J, Qiu J (2016) Beneficial effects of grape seed proanthocyanidin extract on arterial remodeling in spontaneously hypertensive rats via protecting against oxidative stress. Mol Med Rep 14(4):3711\u20133718. https:\/\/doi.org\/10.3892\/mmr.2016.5699","journal-title":"Mol Med Rep"},{"issue":"1","key":"721_CR109","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.ajcnut.2023.05.001","volume":"118","author":"X Lin","year":"2023","unstructured":"Lin X, Zhao J, Ge S, Lu H, Xiong Q, Guo X, Li L, He S, Wang J, Peng F, Fan Y, Zuo X, Tian C, Ying C (2023) Dietary polyphenol intake and risk of hypertension: an 18-y nationwide cohort study in China. Am J Clin Nutr 118(1):264\u2013272. https:\/\/doi.org\/10.1016\/j.ajcnut.2023.05.001","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"721_CR110","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.1161\/HYPERTENSIONAHA.107.107672","volume":"51","author":"R Lopez-Sepulveda","year":"2008","unstructured":"Lopez-Sepulveda R, Jimenez R, Romero M, Zarzuelo MJ, Sanchez M, Gomez-Guzman M, Vargas F, O\u2019Valle F, Zarzuelo A, Perez-Vizcaino F, Duarte J (2008) Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Hypertension 51(4):1088\u20131095. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.107.107672","journal-title":"Hypertension"},{"issue":"1","key":"721_CR111","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/01.fjc.0000162769.83324.c1","volume":"46","author":"A Machha","year":"2005","unstructured":"Machha A, Mustafa MR (2005) Chronic treatment with flavonoids prevents endothelial dysfunction in spontaneously hypertensive rat aorta. J Cardiovasc Pharmacol 46(1):36\u201340","journal-title":"J Cardiovasc Pharmacol"},{"issue":"5","key":"721_CR112","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1159\/000194271","volume":"46","author":"SV Madeira","year":"2009","unstructured":"Madeira SV, Auger C, Anselm E, Chataigneau M, Chataigneau T, Soares de Moura R, Schini-Kerth VB (2009) eNOS activation Induced by a polyphenol-rich grape skin extract in porcine coronary arteries. J Vasc Res 46(5):406\u2013416. 000194271 [pii]. https:\/\/doi.org\/10.1159\/000194271","journal-title":"J Vasc Res"},{"issue":"3","key":"721_CR113","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/jmf.2000.3.141","volume":"3","author":"MA Maher","year":"2000","unstructured":"Maher MA, Mataczynski H, Stefaniak HM, Wilson T (2000) Cranberry juice induces nitric oxide-dependent vasodilation in vitro and its infusion transiently reduces blood pressure in anesthetized rats. J Med Food 3(3):141\u2013147","journal-title":"J Med Food"},{"issue":"6","key":"721_CR114","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1038\/sj.bjp.0704603","volume":"135","author":"S Martin","year":"2002","unstructured":"Martin S, Andriambeloson E, Takeda K, Andriantsitohaina R (2002) Red wine polyphenols increase calcium in bovine aortic endothelial cells: a basis to elucidate signalling pathways leading to nitric oxide production. Br J Pharmacol 135(6):1579\u20131587. https:\/\/doi.org\/10.1038\/sj.bjp.0704603","journal-title":"Br J Pharmacol"},{"issue":"10","key":"721_CR115","doi-asserted-by":"publisher","first-page":"8735","DOI":"10.1039\/D0FO00981D","volume":"11","author":"A Mas-Capdevila","year":"2020","unstructured":"Mas-Capdevila A, Iglesias-Carres L, Arola-Arnal A, Su\u00e1rez M, Bravo FI, Muguerza B (2020) Changes in arterial blood pressure caused by long-term administration of grape seed proanthocyanidins in rats with established hypertension. Food Funct 11(10):8735\u20138742. https:\/\/doi.org\/10.1039\/D0FO00981D","journal-title":"Food Funct"},{"issue":"3","key":"721_CR116","doi-asserted-by":"publisher","first-page":"538","DOI":"10.3945\/ajcn.114.092189","volume":"101","author":"D Mastroiacovo","year":"2015","unstructured":"Mastroiacovo D, Kwik-Uribe C, Grassi D, Necozione S, Raffaele A, Pistacchio L, Righetti R, Bocale R, Lechiara MC, Marini C, Ferri C, Desideri G (2015) Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the cocoa, cognition, and ageing (CoCoA) study \u2013 a randomized controlled trial. Am J Clin Nutr 101(3):538\u2013548. https:\/\/doi.org\/10.3945\/ajcn.114.092189","journal-title":"Am J Clin Nutr"},{"issue":"2","key":"721_CR117","doi-asserted-by":"publisher","first-page":"E92","DOI":"10.3390\/antiox9020092","volume":"9","author":"A Matute","year":"2020","unstructured":"Matute A, Tabart J, Cheramy-Bien J-P, Pirotte B, Kevers C, Auger C, Schini-Kerth V, Dommes J, Defraigne J-O, Pincemail J (2020) Compared phenolic compound contents of 22 commercial fruit and vegetable juices: relationship to ex-vivo vascular reactivity and potential in vivo projection. Antioxid (Basel) 9(2):E92. https:\/\/doi.org\/10.3390\/antiox9020092","journal-title":"Antioxid (Basel)"},{"issue":"9","key":"721_CR118","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1001\/jama.2017.0947","volume":"317","author":"R Micha","year":"2017","unstructured":"Micha R, Pe\u00f1alvo JL, Cudhea F, Imamura F, Rehm CD, Mozaffarian D (2017) Association between dietary factors and mortality from heart disease, stroke, and type 2 diabetes in the United States. JAMA 317(9):912. https:\/\/doi.org\/10.1001\/jama.2017.0947","journal-title":"JAMA"},{"issue":"13","key":"721_CR119","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1161\/01.CIR.0000013836.85741.17","volume":"105","author":"T Minamino","year":"2002","unstructured":"Minamino T, Miyauchi H, Yoshida T, Ishida Y, Yoshida H, Komuro I (2002) Endothelial cell senescence in human atherosclerosis: role of telomere in endothelial dysfunction. Circulation 105(13):1541\u20131544","journal-title":"Circulation"},{"issue":"1","key":"721_CR120","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3177\/jnsv.45.95","volume":"45","author":"K Mizutani","year":"1999","unstructured":"Mizutani K, Ikeda K, Kawai Y, Yamori Y (1999) Extract of wine phenolics improves aortic biomechanical properties in stroke-prone spontaneously hypertensive rats (SHRSP). J Nutr Sci Vitaminol (Tokyo) 45(1):95\u2013106","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"6","key":"721_CR121","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/j.freeradbiomed.2010.06.010","volume":"49","author":"P Mladenka","year":"2010","unstructured":"Mladenka P, Zatloukalova L, Filipsky T, Hrdina R (2010) Cardiovascular effects of flavonoids are not caused only by direct antioxidant activity. Free Radic Biol Med 49(6):963\u2013975. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2010.06.010","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"721_CR122","first-page":"109","volume":"43","author":"S Moncada","year":"1991","unstructured":"Moncada S, Palmer RM, Higgs EA (1991) Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 43(2):109\u2013142","journal-title":"Pharmacol Rev"},{"issue":"23","key":"721_CR123","doi-asserted-by":"publisher","first-page":"00724","DOI":"10.1016\/j.jtha.2023.09.022","volume":"S1538\u2013S7836","author":"A Mroueh","year":"2023","unstructured":"Mroueh A, Fakih W, Carmona A, Trimaille A, Matsushita K, Marchandot B, Qureshi AW, Gong D-S, Auger C, Sattler L, Reydel A, Hess S, Oulehri W, Vollmer O, Lessinger J-M, Meyer N, Pieper MP, Jesel L, B\u00e4ck M, Schini-Kerth V, Morel O (2023) COVID-19 promotes endothelial dysfunction and thrombogenicity: role of proinflammatory cytokines\/SGLT2 prooxidant pathway. J Thromb Haemost S1538\u2013S7836(23):00724\u201300729. https:\/\/doi.org\/10.1016\/j.jtha.2023.09.022","journal-title":"J Thromb Haemost"},{"issue":"2","key":"721_CR124","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbrc.2003.09.028","volume":"310","author":"M Ndiaye","year":"2003","unstructured":"Ndiaye M, Chataigneau T, Andriantsitohaina R, Stoclet JC, Schini-Kerth VB (2003) Red wine polyphenols cause endothelium-dependent EDHF-mediated relaxations in porcine coronary arteries via a redox-sensitive mechanism. Biochem Biophys Res Commun 310(2):371\u2013377. S0006291X03018151 [pii]","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"721_CR125","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1096\/fj.04-2146fje","volume":"19","author":"M Ndiaye","year":"2005","unstructured":"Ndiaye M, Chataigneau M, Lobysheva I, Chataigneau T, Schini-Kerth VB (2005) Red wine polyphenol-induced, endothelium-dependent NO-mediated relaxation is due to the redox-sensitive PI3-kinase\/Akt-dependent phosphorylation of endothelial NO-synthase in the isolated porcine coronary artery. FASEB J 19(3):455\u2013457. 04-2146fje [pii]. https:\/\/doi.org\/10.1096\/fj.04-2146fje","journal-title":"FASEB J"},{"issue":"1","key":"721_CR126","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/jn\/134.1.38","volume":"134","author":"H Negishi","year":"2004","unstructured":"Negishi H, Xu JW, Ikeda K, Njelekela M, Nara Y, Yamori Y (2004) Black and green tea polyphenols attenuate blood pressure increases in stroke-prone spontaneously hypertensive rats. J Nutr 134(1):38\u201342","journal-title":"J Nutr"},{"key":"721_CR127","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1472-6882-13-27","volume":"13","author":"P Nyadjeu","year":"2013","unstructured":"Nyadjeu P, Nguelefack-Mbuyo EP, Atsamo AD, Nguelefack TB, Dongmo AB, Kamanyi A (2013) Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-Induced hypertensive rats. BMC Complement Altern Med 13:27","journal-title":"BMC Complement Altern Med"},{"key":"721_CR128","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.freeradbiomed.2018.03.018","volume":"122","author":"M-H Oak","year":"2018","unstructured":"Oak M-H, Auger C, Belcastro E, Park S-H, Lee H-H, Schini-Kerth VB (2018) Potential mechanisms underlying cardiovascular protection by polyphenols: role of the endothelium. Free Radic Biol Med 122:161\u2013170. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2018.03.018","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"721_CR129","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.numecd.2014.01.016","volume":"24","author":"I Onakpoya","year":"2014","unstructured":"Onakpoya I, Spencer E, Heneghan C, Thompson M (2014) The effect of green tea on blood pressure and lipid profile: a systematic review and meta-analysis of randomized clinical trials. Nutr Metab Cardiovasc Dis 24(8):823\u2013836","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"10","key":"721_CR130","doi-asserted-by":"crossref","first-page":"e13609","DOI":"10.1371\/journal.pone.0013609","volume":"5","author":"LM Oude Griep","year":"2010","unstructured":"Oude Griep LM, Geleijnse JM, Kromhout D, Ock\u00e9 MC, Verschuren WMM (2010) Raw and processed fruit and vegetable consumption and 10-year coronary heart disease incidence in a population-based cohort study in The Netherlands. PLoS One 5(10):e13609","journal-title":"PLoS One"},{"key":"721_CR131","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.arr.2016.05.011","volume":"29","author":"I Pantsulaia","year":"2016","unstructured":"Pantsulaia I, Ciszewski WM, Niewiarowska J (2016) Senescent endothelial cells: potential modulators of immunosenescence and ageing. Ageing Res Rev 29:13\u201325. https:\/\/doi.org\/10.1016\/j.arr.2016.05.011","journal-title":"Ageing Res Rev"},{"issue":"7","key":"721_CR132","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1097\/01.hjh.0000234108.08368.01","volume":"24","author":"C Papamichael","year":"2006","unstructured":"Papamichael C, Karatzi K, Karatzis E, Papaioannou TG, Katsichti P, Zampelas A, Lekakis J (2006) Combined acute effects of red wine consumption and cigarette smoking on Haemodynamics of Young smokers. J Hypertens 24(7):1287\u20131292. https:\/\/doi.org\/10.1097\/01.hjh.0000234108.08368.01","journal-title":"J Hypertens"},{"issue":"1\u20134","key":"721_CR133","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/biof.5520220128","volume":"22","author":"YK Park","year":"2004","unstructured":"Park YK, Kim JS, Kang MH (2004) Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trial. Biofactors 22(1\u20134):145\u2013147","journal-title":"Biofactors"},{"issue":"2","key":"721_CR134","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1017\/S0007114515004328","volume":"115","author":"E Park","year":"2016","unstructured":"Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B (2016) Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr 115(2):226\u2013238. https:\/\/doi.org\/10.1017\/S0007114515004328","journal-title":"Br J Nutr"},{"issue":"1","key":"721_CR135","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/s12933-020-00997-7","volume":"19","author":"S-H Park","year":"2020","unstructured":"Park S-H, Farooq MA, Gaertner S, Bruckert C, Qureshi AW, Lee H-H, Benrahla D, Pollet B, Stephan D, Ohlmann P, Lessinger J-M, Mayoux E, Auger C, Morel O, Schini-Kerth VB (2020) Empagliflozin improved systolic blood pressure, endothelial dysfunction and heart remodeling in the metabolic syndrome ZSF1 rat. Cardiovasc Diabetol 19(1):19. https:\/\/doi.org\/10.1186\/s12933-020-00997-7","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"721_CR136","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12933-021-01252-3","volume":"20","author":"S-H Park","year":"2021","unstructured":"Park S-H, Belcastro E, Hasan H, Matsushita K, Marchandot B, Abbas M, Toti F, Auger C, Jesel L, Ohlmann P, Morel O, Schini-Kerth VB (2021) Angiotensin II-Induced upregulation of SGLT1 and 2 contributes to human microparticle-stimulated endothelial senescence and dysfunction: protective effect of Gliflozins. Cardiovasc Diabetol 20(1):65. https:\/\/doi.org\/10.1186\/s12933-021-01252-3","journal-title":"Cardiovasc Diabetol"},{"issue":"10","key":"721_CR137","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.3390\/antiox11102026","volume":"11","author":"PD Patil","year":"2022","unstructured":"Patil PD, Melo AC, Westwood BM, Tallant EA, Gallagher PE (2022) A Polyphenol-rich extract from Muscadine grapes prevents hypertension-induced diastolic dysfunction and oxidative stress. Antioxidants 11(10):2026. https:\/\/doi.org\/10.3390\/antiox11102026","journal-title":"Antioxidants"},{"issue":"8","key":"721_CR138","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1097\/01.hjh.0000133734.32125.c7","volume":"22","author":"O Pechanova","year":"2004","unstructured":"Pechanova O, Bernatova I, Babal P, Martinez MC, Kysela S, Stvrtina S, Andriantsitohaina R (2004) Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension. J Hypertens 22(8):1551\u20131559","journal-title":"J Hypertens"},{"issue":"3","key":"721_CR139","doi-asserted-by":"publisher","first-page":"R771","DOI":"10.1152\/ajpregu.00147.2005","volume":"289","author":"N Peng","year":"2005","unstructured":"Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM (2005) Antihypertensive and cognitive effects of grape polyphenols in estrogen-depleted, female, spontaneously hypertensive rats. Am J Physiol Regul Integr Comp Physiol 289(3):R771\u2013R775. https:\/\/doi.org\/10.1152\/ajpregu.00147.2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"721_CR140","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1017\/S0007114516004426","volume":"117","author":"Z Pons","year":"2017","unstructured":"Pons Z, Margalef M, Bravo FI, Arola-Arnal A, Muguerza B (2017) Chronic administration of grape-seed polyphenols attenuates the development of hypertension and improves other cardiometabolic risk factors associated with the metabolic syndrome in cafeteria diet-fed rats. Br J Nutr 117(2):200\u2013208. https:\/\/doi.org\/10.1017\/S0007114516004426","journal-title":"Br J Nutr"},{"issue":"5","key":"721_CR141","doi-asserted-by":"publisher","first-page":"E1378","DOI":"10.1152\/ajpendo.00698.2006","volume":"292","author":"MA Potenza","year":"2007","unstructured":"Potenza MA, Marasciulo FL, Tarquinio M, Tiravanti E, Colantuono G, Federici A, Kim JA, Quon MJ, Montagnani M (2007) EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I\/R injury in SHR. Am J Physiol Endocrinol Metab 292(5):E1378\u2013E1387. https:\/\/doi.org\/10.1152\/ajpendo.00698.2006","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"2","key":"721_CR142","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1080\/07315724.2006.10719525","volume":"25","author":"HG Preuss","year":"2006","unstructured":"Preuss HG, Echard B, Polansky MM, Anderson R (2006) Whole cinnamon and aqueous extracts ameliorate sucrose-induced blood pressure elevations in spontaneously hypertensive rats. J Am Coll Nutr 25(2):144\u2013150","journal-title":"J Am Coll Nutr"},{"issue":"3","key":"721_CR143","doi-asserted-by":"publisher","first-page":"e16974","DOI":"10.1371\/journal.pone.0016974","volume":"6","author":"RT Ras","year":"2011","unstructured":"Ras RT, Zock PL, Draijer R (2011) Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS One 6(3):e16974. https:\/\/doi.org\/10.1371\/journal.pone.0016974","journal-title":"PLoS One"},{"issue":"3","key":"721_CR144","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/diseases6030060","volume":"6","author":"Z Rasines-Perea","year":"2018","unstructured":"Rasines-Perea Z, Ky I, Cros G, Crozier A, Teissedre P-L (2018) Grape pomace: antioxidant activity, potential effect against hypertension and metabolites characterization after intake. Diseases 6(3):60. https:\/\/doi.org\/10.3390\/diseases6030060","journal-title":"Diseases"},{"issue":"3","key":"721_CR145","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","volume":"22","author":"S Reagan-Shaw","year":"2008","unstructured":"Reagan-Shaw S, Nihal M, Ahmad N (2008) Dose translation from animal to human studies revisited. FASEB J 22(3):659\u2013661. https:\/\/doi.org\/10.1096\/fj.07-9574LSF","journal-title":"FASEB J"},{"issue":"8808","key":"721_CR146","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/0140-6736(92)91277-F","volume":"339","author":"S Renaud","year":"1992","unstructured":"Renaud S, de Lorgeril M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart Disease. Lancet 339(8808):1523\u20131526","journal-title":"Lancet"},{"issue":"4","key":"721_CR147","doi-asserted-by":"publisher","first-page":"415","DOI":"10.3390\/nu9040415","volume":"9","author":"J Rienks","year":"2017","unstructured":"Rienks J, Barbaresko J, N\u00f6thlings U (2017) Association of polyphenol biomarkers with cardiovascular disease and mortality risk: a systematic review and meta-analysis of observational studies. Nutrients 9(4):415. https:\/\/doi.org\/10.3390\/nu9040415","journal-title":"Nutrients"},{"issue":"6","key":"721_CR148","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1016\/j.bcp.2008.11.027","volume":"77","author":"L Rivera","year":"2009","unstructured":"Rivera L, Moron R, Zarzuelo A, Galisteo M (2009) Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats. Biochem Pharmacol 77(6):1053\u20131063. https:\/\/doi.org\/10.1016\/j.bcp.2008.11.027","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"721_CR149","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.3945\/ajcn.113.066639","volume":"98","author":"A Rodriguez-Mateos","year":"2013","unstructured":"Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP (2013) Intake and time dependence of blueberry flavonoid\u2013induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. Am J Clin Nutr 98(5):1179\u20131191. https:\/\/doi.org\/10.3945\/ajcn.113.066639","journal-title":"Am J Clin Nutr"},{"issue":"2\u20133","key":"721_CR150","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.vph.2009.04.003","volume":"51","author":"M Roghani","year":"2009","unstructured":"Roghani M, Baluchnejadmojarad T (2009) Chronic epigallocatechin-Gallate improves aortic reactivity of diabetic rats: underlying mechanisms. Vascul Pharmacol 51(2\u20133):84\u201389. https:\/\/doi.org\/10.1016\/j.vph.2009.04.003","journal-title":"Vascul Pharmacol"},{"issue":"Suppl 2","key":"721_CR151","doi-asserted-by":"publisher","first-page":"S148","DOI":"10.1002\/ptr.3032","volume":"24","author":"M Roghani","year":"2010","unstructured":"Roghani M, Baluchnejadmojarad T (2010) Mechanisms underlying vascular effect of chronic resveratrol in streptozotocin-diabetic rats. Phytother Res 24(Suppl 2):S148\u2013S154. https:\/\/doi.org\/10.1002\/ptr.3032","journal-title":"Phytother Res"},{"issue":"1","key":"721_CR152","first-page":"21","volume":"11","author":"A Rostami","year":"2015","unstructured":"Rostami A, Khalili M, Haghighat N, Eghtesadi S, Shidfar F, Heidari I, Ebrahimpour-Koujan S, Eghtesadi M (2015) High-cocoa polyphenol-rich chocolate improves blood pressure in patients with diabetes and hypertension. ARYA Atheroscler 11(1):21\u201329","journal-title":"ARYA Atheroscler"},{"issue":"1","key":"721_CR153","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/01.hjh.0000198029.22472.d9","volume":"24","author":"M Sanchez","year":"2006","unstructured":"Sanchez M, Galisteo M, Vera R, Villar IC, Zarzuelo A, Tamargo J, Perez-Vizcaino F, Duarte J (2006) Quercetin downregulates NADPH oxidase, increases eNOS activity and prevents endothelial dysfunction in spontaneously hypertensive rats. J Hypertens 24(1):75\u201384","journal-title":"J Hypertens"},{"issue":"4","key":"721_CR154","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.cardiores.2006.05.022","volume":"71","author":"M Sarr","year":"2006","unstructured":"Sarr M, Chataigneau M, Martins S, Schott C, El Bedoui J, Oak MH, Muller B, Chataigneau T, Schini-Kerth VB (2006) Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res 71(4):794\u2013802. https:\/\/doi.org\/10.1016\/j.cardiores.2006.05.022","journal-title":"Cardiovasc Res"},{"issue":"4","key":"721_CR155","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1073\/pnas.0510168103","volume":"103","author":"H Schroeter","year":"2006","unstructured":"Schroeter H, Heiss C, Balzer J, Kleinbongard P, Keen CL, Hollenberg NK, Sies H, Kwik-Uribe C, Schmitz HH, Kelm M (2006) (\u2212)-Epicatechin mediates beneficial effects of Flavanol-Rich cocoa on vascular function in humans. Proc Natl Acad Sci U S A 103(4):1024\u20131029. https:\/\/doi.org\/10.1073\/pnas.0510168103","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"721_CR156","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1042\/CS20100476","volume":"120","author":"DR Seals","year":"2011","unstructured":"Seals DR, Jablonski KL, Donato AJ (2011) Ageing and vascular endothelial function in humans. Clin Sci (Lond) 120(9):357\u2013375. https:\/\/doi.org\/10.1042\/CS20100476","journal-title":"Clin Sci (Lond)"},{"issue":"2","key":"721_CR157","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.nutres.2009.01.001","volume":"29","author":"KS Shaughnessy","year":"2009","unstructured":"Shaughnessy KS, Boswall IA, Scanlan AP, Gottschall-Pass KT, Sweeney MI (2009) Diets containing blueberry extract lower blood pressure in spontaneously hypertensive stroke-prone rats. Nutr Res 29(2):130\u2013138. https:\/\/doi.org\/10.1016\/j.nutres.2009.01.001","journal-title":"Nutr Res"},{"issue":"1","key":"721_CR158","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1038\/35036093","volume":"1","author":"JW Shay","year":"2000","unstructured":"Shay JW, Wright WE (2000) Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol 1(1):72\u201376. https:\/\/doi.org\/10.1038\/35036093","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"6","key":"721_CR159","doi-asserted-by":"publisher","first-page":"5528","DOI":"10.3892\/mmr.2016.5929","volume":"14","author":"X Shen","year":"2016","unstructured":"Shen X, Wang M, Bi X, Zhang J, Wen S, Fu G, Xia L (2016) Resveratrol prevents endothelial progenitor cells from senescence and reduces the oxidative reaction via PPAR-\u03b3\/HO-1 pathways. Mol Med Rep 14(6):5528\u20135534. https:\/\/doi.org\/10.3892\/mmr.2016.5929","journal-title":"Mol Med Rep"},{"key":"721_CR160","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.exger.2017.04.006","volume":"93","author":"GC Silva","year":"2017","unstructured":"Silva GC, Abbas M, Khemais-Benkhiat S, Burban M, Ribeiro TP, Toti F, Idris-Khodja N, C\u00f4rtes SF, Schini-Kerth VB (2017) Replicative senescence promotes prothrombotic responses in endothelial cells: role of NADPH oxidase- and cyclooxygenase-derived oxidative stress. Exp Gerontol 93:7\u201315. https:\/\/doi.org\/10.1016\/j.exger.2017.04.006","journal-title":"Exp Gerontol"},{"key":"721_CR161","doi-asserted-by":"publisher","first-page":"a1344","DOI":"10.1136\/bmj.a1344","volume":"337","author":"F Sofi","year":"2008","unstructured":"Sofi F, Cesari F, Abbate R, Gensini GF, Casini A (2008) Adherence to Mediterranean diet and health status: meta-analysis. BMJ 337:a1344. https:\/\/doi.org\/10.1136\/bmj.a1344","journal-title":"BMJ"},{"issue":"12","key":"721_CR162","doi-asserted-by":"publisher","first-page":"2769","DOI":"10.1017\/S1368980013003169","volume":"17","author":"F Sofi","year":"2014","unstructured":"Sofi F, Macchi C, Abbate R, Gensini GF, Casini A (2014) Mediterranean diet and health status: an updated meta-analysis and a proposal for a literature-based adherence score. Public Health Nutr 17(12):2769\u20132782. https:\/\/doi.org\/10.1017\/S1368980013003169","journal-title":"Public Health Nutr"},{"issue":"Suppl 1","key":"721_CR163","doi-asserted-by":"publisher","first-page":"S44","DOI":"10.1002\/mnfr.200800169","volume":"53","author":"A Stalmach","year":"2009","unstructured":"Stalmach A, Troufflard S, Serafini M, Crozier A (2009) Absorption, metabolism and excretion of Choladi green tea Flavan-3-Ols by humans. Mol Nutr Food Res 53(Suppl 1):S44\u2013S53. https:\/\/doi.org\/10.1002\/mnfr.200800169","journal-title":"Mol Nutr Food Res"},{"issue":"4","key":"721_CR164","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/0091-7435(92)90062-M","volume":"21","author":"I Stensvold","year":"1992","unstructured":"Stensvold I, Tverdal A, Solvoll K, Foss OP (1992) Tea consumption. Relationship to cholesterol, blood pressure, and coronary and total mortality. Prev Med 21(4):546\u2013553","journal-title":"Prev Med"},{"issue":"8","key":"721_CR165","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1248\/bpb.b15-00012","volume":"38","author":"Y Sun","year":"2015","unstructured":"Sun Y, Hu X, Hu G, Xu C, Jiang H (2015) Curcumin attenuates hydrogen peroxide-Induced premature senescence via the activation of SIRT1 in human umbilical vein endothelial cells. Biol Pharm Bull 38(8):1134\u20131141. https:\/\/doi.org\/10.1248\/bpb.b15-00012","journal-title":"Biol Pharm Bull"},{"issue":"6","key":"721_CR166","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.1097\/01.hjh.0000226196.67052.c0","volume":"24","author":"A Suzuki","year":"2006","unstructured":"Suzuki A, Yamamoto N, Jokura H, Yamamoto M, Fujii A, Tokimitsu I, Saito I (2006) Chlorogenic acid attenuates hypertension and improves endothelial function in spontaneously hypertensive rats. J Hypertens 24(6):1065\u20131073. https:\/\/doi.org\/10.1097\/01.hjh.0000226196.67052.c0","journal-title":"J Hypertens"},{"issue":"2","key":"721_CR167","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1161\/01.HYP.38.2.274","volume":"38","author":"S Taddei","year":"2001","unstructured":"Taddei S, Virdis A, Ghiadoni L, Salvetti G, Bernini G, Magagna A, Salvetti A (2001) Age-related reduction of NO availability and oxidative stress in humans. Hypertension 38(2):274\u2013279","journal-title":"Hypertension"},{"issue":"8","key":"721_CR168","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1001\/jama.290.8.1029","volume":"290","author":"D Taubert","year":"2003","unstructured":"Taubert D, Berkels R, Roesen R, Klaus W (2003) Chocolate and blood pressure in elderly individuals with isolated systolic hypertension. JAMA 290(8):1029\u20131030. https:\/\/doi.org\/10.1001\/jama.290.8.1029","journal-title":"JAMA"},{"issue":"7","key":"721_CR169","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1017\/S0007114515000562","volume":"114","author":"TE Tjelle","year":"2015","unstructured":"Tjelle TE, Holtung L, Bohn SK, Aaby K, Thoresen M, Wiik SA, Paur I, Karlsen AS, Retterstol K, Iversen PO, Blomhoff R (2015) Polyphenol-rich juices reduce blood pressure measures in a randomised controlled trial in high normal and hypertensive volunteers. Br J Nutr 114(7):1054\u20131063","journal-title":"Br J Nutr"},{"key":"721_CR170","doi-asserted-by":"publisher","first-page":"588000","DOI":"10.3389\/fphys.2020.588000","volume":"11","author":"T Tropea","year":"2020","unstructured":"Tropea T, Greenwood SL, Sibley CP, Cottrell EC (2020) Grape seed extract polyphenols improve resistance artery function in pregnant eNOS\u2013\/\u2013 mice. Front Physiol 11:588000. https:\/\/doi.org\/10.3389\/fphys.2020.588000","journal-title":"Front Physiol"},{"key":"721_CR171","doi-asserted-by":"publisher","unstructured":"Tsao CW, Aday AW, Almarzooq ZI, Alonso A, Beaton AZ, Bittencourt MS, Boehme AK, Buxton AE, Carson AP, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Ferguson JF, Generoso G, Ho JE, Kalani R, Khan SS, Kissela BM, Knutson KL, Levine DA, Lewis TT, Liu J, Loop MS, Ma J, Mussolino ME, Navaneethan SD, Perak AM, Poudel R, Rezk-Hanna M, Roth GA, Schroeder EB, Shah SH, Thacker EL, VanWagner LB, Virani SS, Voecks JH, Wang N-Y, Yaffe K, Martin SS, on behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee (2022) Heart disease and stroke statistics \u2013 2022 update: a report from the American Heart Association. Circulation 145(8). https:\/\/doi.org\/10.1161\/CIR.0000000000001052","DOI":"10.1161\/CIR.0000000000001052"},{"key":"721_CR172","doi-asserted-by":"publisher","unstructured":"Tsao CW, Aday AW, Almarzooq ZI, Anderson CAM, Arora P, Avery CL, Baker-Smith CM, Beaton AZ, Boehme AK, Buxton AE, Commodore-Mensah Y, Elkind MSV, Evenson KR, Eze-Nliam C, Fugar S, Generoso G, Heard DG, Hiremath S, Ho JE, Kalani R, Kazi DS, Ko D, Levine DA, Liu J, Ma J, Magnani JW, Michos ED, Mussolino ME, Navaneethan SD, Parikh NI, Poudel R, Rezk-Hanna M, Roth GA, Shah NS, St-Onge M-P, Thacker EL, Virani SS, Voeks JH, Wang N-Y, Wong ND, Wong SS, Yaffe K, Martin SS, on behalf of the American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee (2023) Heart disease and stroke statistics\u20142023 update: a report from the American Heart Association. Circulation 147(8). https:\/\/doi.org\/10.1161\/CIR.0000000000001123","DOI":"10.1161\/CIR.0000000000001123"},{"issue":"1","key":"721_CR173","doi-asserted-by":"publisher","first-page":"11855","DOI":"10.1038\/s41598-022-15976-z","volume":"12","author":"R Urata","year":"2022","unstructured":"Urata R, Ikeda K, Yamazaki E, Ueno D, Katayama A, Shin-Ya M, Ohgitani E, Mazda O, Matoba S (2022) Senescent endothelial cells are predisposed to SARS-CoV-2 infection and subsequent endothelial dysfunction. Sci Rep 12(1):11855. https:\/\/doi.org\/10.1038\/s41598-022-15976-z","journal-title":"Sci Rep"},{"issue":"4","key":"721_CR174","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1253\/circj.CJ-08-1169","volume":"73","author":"PM Vanhoutte","year":"2009","unstructured":"Vanhoutte PM (2009) Endothelial dysfunction: the first step toward coronary arteriosclerosis. Circ J 73(4):595\u2013601","journal-title":"Circ J"},{"issue":"1","key":"721_CR175","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/apha.12646","volume":"219","author":"PM Vanhoutte","year":"2017","unstructured":"Vanhoutte PM, Shimokawa H, Feletou M, Tang EH (2017) Endothelial dysfunction and vascular disease \u2013 a 30th anniversary update. Acta Physiol 219(1):22\u201396","journal-title":"Acta Physiol"},{"issue":"3","key":"721_CR176","doi-asserted-by":"publisher","first-page":"1300","DOI":"10.1124\/jpet.105.085530","volume":"314","author":"R Vera","year":"2005","unstructured":"Vera R, Galisteo M, Villar IC, Sanchez M, Zarzuelo A, Perez-Vizcaino F, Duarte J (2005) Soy Isoflavones improve endothelial function in spontaneously hypertensive rats in an estrogen-independent manner: role of nitric-oxide synthase, superoxide, and cyclooxygenase metabolites. J Pharmacol Exp Ther 314(3):1300\u20131309. https:\/\/doi.org\/10.1124\/jpet.105.085530","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"721_CR177","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/01.CIR.0000028581.07992.56","volume":"106","author":"JA Vita","year":"2002","unstructured":"Vita JA, Keaney JF (2002) Endothelial function: a barometer for cardiovascular risk? Circulation 106(6):640\u2013642","journal-title":"Circulation"},{"issue":"1","key":"721_CR178","doi-asserted-by":"publisher","first-page":"030006052098536","DOI":"10.1177\/0300060520985363","volume":"49","author":"D Wang","year":"2021","unstructured":"Wang D, Hou J, Wan J, Yang Y, Liu S, Li X, Li W, Dai X, Zhou P, Liu W, Wang P (2021) Dietary chlorogenic acid ameliorates oxidative stress and improves endothelial function in diabetic mice via Nrf2 activation. J Int Med Res 49(1):030006052098536. https:\/\/doi.org\/10.1177\/0300060520985363","journal-title":"J Int Med Res"},{"key":"721_CR179","unstructured":"Wilkins E, Wilson L, Wickramasinghe K, Bhatnagar P, Leal J, Luengo-Fernandez R, Burns R, Rayner M, Townsend N (2017) European Cardiovascular Disease Statistics 2017; European Heart Network: Brussels"},{"key":"721_CR180","unstructured":"World Health Organization (2023) WHO Fact Sheet \u2013 Cardiovascular diseases (CVDs). World Health Organization. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds). Accessed 20 Oct 2023"},{"issue":"9","key":"721_CR181","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1017\/S0007114520001993","volume":"124","author":"Y Yang","year":"2020","unstructured":"Yang Y, Dong J-Y, Cui R, Muraki I, Yamagishi K, Sawada N, Iso H, Tsugane S (2020) For the Japan public health center-based prospective study group. Consumption of flavonoid-rich fruits and risk of CHD: a prospective cohort study. Br J Nutr 124(9):952\u2013959. https:\/\/doi.org\/10.1017\/S0007114520001993","journal-title":"Br J Nutr"},{"issue":"18","key":"721_CR182","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1161\/CIRCULATIONAHA.106.678276","volume":"115","author":"J Yeboah","year":"2007","unstructured":"Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM (2007) Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: the cardiovascular health study. Circulation 115(18):2390\u20132397. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.106.678276","journal-title":"Circulation"},{"issue":"6","key":"721_CR183","doi-asserted-by":"publisher","first-page":"1280","DOI":"10.1080\/10408398.2014.989958","volume":"57","author":"K Zaheer","year":"2017","unstructured":"Zaheer K, Humayoun Akhtar M (2017) An updated review of dietary Isoflavones: nutrition, processing, bioavailability and impacts on human health. Crit Rev Food Sci Nutr 57(6):1280\u20131293. https:\/\/doi.org\/10.1080\/10408398.2014.989958","journal-title":"Crit Rev Food Sci Nutr"},{"issue":"4","key":"721_CR184","doi-asserted-by":"publisher","first-page":"1359","DOI":"10.1007\/s00394-015-0950-x","volume":"55","author":"R Zamora-Ros","year":"2016","unstructured":"Zamora-Ros R, Knaze V, Rothwell JA, H\u00e9mon B, Moskal A, Overvad K, Tj\u00f8nneland A, Kyr\u00f8 C, Fagherazzi G, Boutron-Ruault M-C, Touillaud M, Katzke V, K\u00fchn T, Boeing H, F\u00f6rster J, Trichopoulou A, Valanou E, Peppa E, Palli D, Agnoli C, Ricceri F, Tumino R, De Magistris MS, Peeters PHM, Bueno-de-Mesquita HB, Engeset D, Skeie G, Hjart\u00e5ker A, Men\u00e9ndez V, Agudo A, Molina-Montes E, Huerta JM, Barricarte A, Amiano P, Sonestedt E, Nilsson LM, Landberg R, Key TJ, Khaw K-T, Wareham NJ, Lu Y, Slimani N, Romieu I, Riboli E, Scalbert A (2016) Dietary polyphenol intake in Europe: the European prospective investigation into cancer and nutrition (EPIC) study. Eur J Nutr 55(4):1359\u20131375. https:\/\/doi.org\/10.1007\/s00394-015-0950-x","journal-title":"Eur J Nutr"},{"issue":"12","key":"721_CR185","doi-asserted-by":"publisher","first-page":"e0143814","DOI":"10.1371\/journal.pone.0143814","volume":"10","author":"E Zhang","year":"2015","unstructured":"Zhang E, Guo Q, Gao H, Xu R, Teng S, Wu Y (2015) Metformin and resveratrol inhibited high glucose-induced metabolic memory of endothelial senescence through SIRT1\/P300\/P53\/P21 pathway. PLoS One 10(12):e0143814. https:\/\/doi.org\/10.1371\/journal.pone.0143814","journal-title":"PLoS One"},{"issue":"9","key":"721_CR186","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1139\/cjpp-2020-0583","volume":"99","author":"L Zhang","year":"2021","unstructured":"Zhang L, Zheng J, Tie X, Lin T, Yang W, Li Z, Zou Y, Guan G, Liu P, Luo W, Li Z (2021) Pterostilbene and its nicotinate derivative ameliorated vascular endothelial senescence and elicited endothelium-dependent relaxations via activation of Sirtuin 1. Can J Physiol Pharmacol 99(9):900\u2013909. https:\/\/doi.org\/10.1139\/cjpp-2020-0583","journal-title":"Can J Physiol Pharmacol"},{"issue":"4","key":"721_CR187","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s10654-022-00858-5","volume":"37","author":"B Zhao","year":"2022","unstructured":"Zhao B, Gan L, Yu K, M\u00e4nnist\u00f6 S, Huang J, Albanes D (2022) Relationship between chocolate consumption and overall and cause-specific mortality, systematic review and updated meta-analysis. Eur J Epidemiol 37(4):321\u2013333. https:\/\/doi.org\/10.1007\/s10654-022-00858-5","journal-title":"Eur J Epidemiol"},{"key":"721_CR188","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2022.12.006","volume":"365","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Li D, Huang T (2023) Associations of dietary flavonoids and subclasses with total and cardiovascular mortality among 369,827 older people: the NIH-AARP diet and health study. Atherosclerosis 365:1\u20138. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2022.12.006","journal-title":"Atherosclerosis"},{"issue":"11","key":"721_CR189","doi-asserted-by":"publisher","first-page":"1524","DOI":"10.1373\/clinchem.2011.167361","volume":"57","author":"Y Zhu","year":"2011","unstructured":"Zhu Y, Xia M, Yang Y, Liu F, Li Z, Hao Y, Mi M, Jin T, Ling W (2011) Purified anthocyanin supplementation improves endothelial function via NO-cGMP activation in hypercholesterolemic individuals. Clin Chem 57(11):1524\u20131533. https:\/\/doi.org\/10.1373\/clinchem.2011.167361","journal-title":"Clin Chem"},{"issue":"4","key":"721_CR190","doi-asserted-by":"publisher","first-page":"644","DOI":"10.1111\/acel.12344","volume":"14","author":"Y Zhu","year":"2015","unstructured":"Zhu Y, Tchkonia T, Pirtskhalava T, Gower AC, Ding H, Giorgadze N, Palmer AK, Ikeno Y, Hubbard GB, Lenburg M, O\u2019Hara SP, LaRusso NF, Miller JD, Roos CM, Verzosa GC, LeBrasseur NK, Wren JD, Farr JN, Khosla S, Stout MB, McGowan SJ, Fuhrmann-Stroissnigg H, Gurkar AU, Zhao J, Colangelo D, Dorronsoro A, Ling YY, Barghouthy AS, Navarro DC, Sano T, Robbins PD, Niedernhofer LJ, Kirkland JL (2015) The Achilles\u2019 heel of senescent cells: from transcriptome to senolytic drugs. Ageing Cell 14(4):644\u2013658. https:\/\/doi.org\/10.1111\/acel.12344","journal-title":"Ageing Cell"}],"container-title":["Handbook of Experimental Pharmacology","Natural Products as Sources of Novel Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2024_721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T21:07:21Z","timestamp":1737580041000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2024_721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,25]]},"ISBN":["9783031802928","9783031802935"],"references-count":190,"URL":"https:\/\/doi.org\/10.1007\/164_2024_721","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,25]]},"assertion":[{"value":"25 September 2024","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}