{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:40:42Z","timestamp":1777066842153,"version":"3.51.4"},"publisher-location":"Cham","reference-count":144,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032244314","type":"print"},{"value":"9783032244321","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/164_2025_753","type":"book-chapter","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T15:23:01Z","timestamp":1759850581000},"page":"147-171","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Naturally Occurring H2S-Donors in Vascular Diseases"],"prefix":"10.1007","author":[{"given":"Lorenzo","family":"Flori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Spezzini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Piragine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Citi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Calderone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alma","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,8]]},"reference":[{"key":"753_CR1","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1523\/jneurosci.16-03-01066.1996","volume":"16","author":"K Abe","year":"1996","unstructured":"Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16:1066\u20131071. https:\/\/doi.org\/10.1523\/jneurosci.16-03-01066.1996","journal-title":"J Neurosci"},{"key":"753_CR2","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/s41371-019-0273-0","volume":"33","author":"A Aboonabi","year":"2019","unstructured":"Aboonabi A, Meyer RR, Singh I (2019) The association between metabolic syndrome components and the development of atherosclerosis. J Hum Hypertens 33:844\u2013855","journal-title":"J Hum Hypertens"},{"key":"753_CR3","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.phymed.2018.10.023","volume":"54","author":"D Aekthammarat","year":"2019","unstructured":"Aekthammarat D, Pannangpetch P, Tangsucharit P (2019) Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats. Phytomedicine 54:9\u201316","journal-title":"Phytomedicine"},{"key":"753_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110605","volume":"130","author":"D Aekthammarat","year":"2020","unstructured":"Aekthammarat D, Tangsucharit P, Pannangpetch P, Sriwantana T, Sibmooh N (2020) Moringa oleifera leaf extract enhances endothelial nitric oxide production leading to relaxation of resistance artery and lowering of arterial blood pressure. Biomed Pharmacother 130:110605","journal-title":"Biomed Pharmacother"},{"key":"753_CR5","doi-asserted-by":"publisher","first-page":"619","DOI":"10.3390\/antiox9070619","volume":"9","author":"J Ansary","year":"2020","unstructured":"Ansary J, Forbes-Hern\u00e1ndez TY, Gil E, Cianciosi D, Zhang J, Elexpuru-Zabaleta M, Simal-Gandara J, Giampieri F, Battino M (2020) Potential health benefit of garlic based on human intervention studies: a brief overview. Antioxidants 9:619","journal-title":"Antioxidants"},{"key":"753_CR6","doi-asserted-by":"publisher","first-page":"712","DOI":"10.3945\/ajcn.113.065235","volume":"98","author":"CN Armah","year":"2013","unstructured":"Armah CN, Traka MH, Dainty JR, Defernez M, Janssens A, Leung W, Doleman JF, Potter JF, Mithen RF (2013) A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function. Am J Clin Nutr 98:712\u2013722. https:\/\/doi.org\/10.3945\/ajcn.113.065235","journal-title":"Am J Clin Nutr"},{"key":"753_CR7","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jep.2003.06.001","volume":"90","author":"MZ Ashraf","year":"2004","unstructured":"Ashraf MZ, Hussain ME, Fahim M (2004) Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide. J Ethnopharmacol 90:5\u20139. https:\/\/doi.org\/10.1016\/j.jep.2003.06.001","journal-title":"J Ethnopharmacol"},{"key":"753_CR8","first-page":"859","volume":"26","author":"R Ashraf","year":"2013","unstructured":"Ashraf R, Khan RA, Ashraf I, Qureshi AA (2013) Effects of Allium sativum (garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci 26:859\u2013863","journal-title":"Pak J Pharm Sci"},{"key":"753_CR9","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1097\/HJH.0000000000001356","volume":"35","author":"Z Bahadoran","year":"2017","unstructured":"Bahadoran Z, Mirmiran P, Momenan AA, Azizi F (2017) Allium vegetable intakes and the incidence of cardiovascular disease, hypertension, chronic kidney disease, and type 2 diabetes in adults: a longitudinal follow-up study. J Hypertens 35:1909\u20131916","journal-title":"J Hypertens"},{"key":"753_CR10","doi-asserted-by":"publisher","first-page":"1755","DOI":"10.3390\/nu16111755","volume":"16","author":"N Bara-Ledesma","year":"2024","unstructured":"Bara-Ledesma N, Jimenez-Esteban J, Fabregate M, Fabregate-Fuente R, Cymberknop LJ, Castillo-Martinez P, Navarro-Fayos MT, Gomez del Olmo V, Saban-Ruiz J (2024) Effect of encapsulated purple garlic oil on microvascular function and the components of metabolic syndrome: a randomized placebo-controlled study\u2014the ENDOTALLIUM study. Nutrients 16:1755","journal-title":"Nutrients"},{"key":"753_CR11","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1017\/s002966511200016x","volume":"71","author":"LN Barrera","year":"2012","unstructured":"Barrera LN, Cassidy A, Johnson IT, Bao Y, Belshaw NJ (2012) Epigenetic and antioxidant effects of dietary isothiocyanates and selenium: potential implications for cancer chemoprevention. Proc Nutr Soc 71:237\u2013245. https:\/\/doi.org\/10.1017\/s002966511200016x","journal-title":"Proc Nutr Soc"},{"key":"753_CR12","doi-asserted-by":"publisher","first-page":"7512","DOI":"10.1021\/acs.jmedchem.7b00888","volume":"60","author":"E Barresi","year":"2017","unstructured":"Barresi E, Nesi G, Citi V, Piragine E, Piano I, Taliani S, Da Settimo F, Rapposelli S, Testai L, Breschi MC (2017) Iminothioethers as hydrogen sulfide donors: from the gasotransmitter release to the vascular effects. J Med Chem 60:7512\u20137523","journal-title":"J Med Chem"},{"key":"753_CR13","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.pharep.2015.01.005","volume":"67","author":"J Be\u0142towski","year":"2015","unstructured":"Be\u0142towski J (2015) Hydrogen sulfide in pharmacology and medicine--An update. Pharmacol Rep 67:647\u2013658. https:\/\/doi.org\/10.1016\/j.pharep.2015.01.005","journal-title":"Pharmacol Rep"},{"key":"753_CR14","doi-asserted-by":"publisher","first-page":"17977","DOI":"10.1073\/pnas.0705710104","volume":"104","author":"GA Benavides","year":"2007","unstructured":"Benavides GA, Squadrito GL, Mills RW, Patel HD, Isbell TS, Patel RP, Darley-Usmar VM, Doeller JE, Kraus DW (2007) Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci USA 104:17977\u201317982. https:\/\/doi.org\/10.1073\/pnas.0705710104","journal-title":"Proc Natl Acad Sci USA"},{"key":"753_CR15","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.niox.2014.12.008","volume":"46","author":"A Berenyiova","year":"2015","unstructured":"Berenyiova A, Grman M, Mijuskovic A, Stasko A, Misak A, Nagy P, Ondriasova E, Cacanyiova S, Brezova V, Feelisch M, Ondrias K (2015) The reaction products of sulfide and S-nitrosoglutathione are potent vasorelaxants. Nitric Oxide 46:123\u2013130. https:\/\/doi.org\/10.1016\/j.niox.2014.12.008","journal-title":"Nitric Oxide"},{"key":"753_CR16","doi-asserted-by":"publisher","first-page":"12591","DOI":"10.3390\/molecules190812591","volume":"19","author":"J Borlinghaus","year":"2014","unstructured":"Borlinghaus J, Albrecht F, Gruhlke MC, Nwachukwu ID, Slusarenko AJ (2014) Allicin: chemistry and biological properties. Molecules 19:12591\u201312618","journal-title":"Molecules"},{"key":"753_CR17","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1161\/atvbaha.110.209783","volume":"30","author":"M Bucci","year":"2010","unstructured":"Bucci M, Papapetropoulos A, Vellecco V, Zhou Z, Pyriochou A, Roussos C, Roviezzo F, Brancaleone V, Cirino G (2010) Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity. Arterioscler Thromb Vasc Biol 30:1998\u20132004. https:\/\/doi.org\/10.1161\/atvbaha.110.209783","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"753_CR18","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1517\/17460441.2016.1122590","volume":"11","author":"V Calderone","year":"2016","unstructured":"Calderone V, Martelli A, Testai L, Citi V, Breschi MC (2016) Using hydrogen sulfide to design and develop drugs. Expert Opin Drug Discov 11:163\u2013175. https:\/\/doi.org\/10.1517\/17460441.2016.1122590","journal-title":"Expert Opin Drug Discov"},{"key":"753_CR19","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.3390\/antiox10101611","volume":"10","author":"C-Y Chen","year":"2021","unstructured":"Chen C-Y, Tsai T-Y, Chen B-H (2021) Effects of black garlic extract and nanoemulsion on the deoxy corticosterone acetate-salt induced hypertension and its associated mild cognitive impairment in rats. Antioxidants 10:1611","journal-title":"Antioxidants"},{"key":"753_CR20","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2021.104309","volume":"141","author":"J Chen","year":"2022","unstructured":"Chen J, Ding X, Chen W, Chen S, Guan Q, Wen J, Chen Z (2022) VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery. Microvasc Res 141:104309","journal-title":"Microvasc Res"},{"key":"753_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012461","volume":"5","author":"B Christiansen","year":"2010","unstructured":"Christiansen B, Bellostas Muguerza N, Petersen AM, Kveiborg B, Madsen CR, Thomas H, Ihlemann N, S\u00f8rensen JC, K\u00f8ber L, S\u00f8rensen H, Torp-Pedersen C, Dom\u00ednguez H (2010) Ingestion of broccoli sprouts does not improve endothelial function in humans with hypertension. PLoS One 5:e12461. https:\/\/doi.org\/10.1371\/journal.pone.0012461","journal-title":"PLoS One"},{"key":"753_CR22","doi-asserted-by":"publisher","first-page":"15593","DOI":"10.3390\/ijms232415593","volume":"23","author":"V Ciccone","year":"2022","unstructured":"Ciccone V, Piragine E, Gorica E, Citi V, Testai L, Pagnotta E, Matteo R, Pecchioni N, Montanaro R, Di Cesare ML (2022) Anti-inflammatory effect of the natural H2S-donor erucin in vascular endothelium. Int J Mol Sci 23:15593","journal-title":"Int J Mol Sci"},{"key":"753_CR23","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1152\/physrev.00028.2021","volume":"103","author":"G Cirino","year":"2023","unstructured":"Cirino G, Szabo C, Papapetropoulos A (2023) Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs. Physiol Rev 103:31\u2013276","journal-title":"Physiol Rev"},{"key":"753_CR24","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1055\/s-0034-1368591","volume":"80","author":"V Citi","year":"2014","unstructured":"Citi V, Martelli A, Testai L, Marino A, Breschi MC, Calderone V (2014) Hydrogen sulfide releasing capacity of natural isothiocyanates: is it a reliable explanation for the multiple biological effects of Brassicaceae? Planta Med 80:610\u2013613. https:\/\/doi.org\/10.1055\/s-0034-1368591","journal-title":"Planta Med"},{"key":"753_CR25","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/ptr.6278","volume":"33","author":"V Citi","year":"2019","unstructured":"Citi V, Piragine E, Pagnotta E, Ugolini L, Di Cesare ML, Testai L, Ghelardini C, Lazzeri L, Calderone V, Martelli A (2019) Anticancer properties of erucin, an H2S-releasing isothiocyanate, on human pancreatic adenocarcinoma cells (AsPC-1). Phytother Res 33:845\u2013855","journal-title":"Phytother Res"},{"key":"753_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105039","volume":"159","author":"V Citi","year":"2020","unstructured":"Citi V, Martelli A, Bucci M, Piragine E, Testai L, Vellecco V, Cirino G, Calderone V (2020) Searching for novel hydrogen sulfide donors: the vascular effects of two thiourea derivatives. Pharmacol Res 159:105039","journal-title":"Pharmacol Res"},{"key":"753_CR27","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.jare.2020.05.015","volume":"27","author":"V Citi","year":"2021","unstructured":"Citi V, Martelli A, Gorica E, Brogi S, Testai L, Calderone V (2021) Role of hydrogen sulfide in endothelial dysfunction: pathophysiology and therapeutic approaches. J Adv Res 27:99\u2013113","journal-title":"J Adv Res"},{"key":"753_CR28","doi-asserted-by":"crossref","unstructured":"Citi V, Piragine E, Calderone V, Martelli A (2022) Hydrogen sulfide: the hidden player of isothiocyanates pharmacology. In: Hydrogen sulfide: chemical biology basics, detection methods, therapeutic applications, and case studies, pp 261\u2013292","DOI":"10.1002\/9781119799900.ch11"},{"key":"753_CR29","doi-asserted-by":"publisher","first-page":"9161","DOI":"10.1073\/pnas.1202916109","volume":"109","author":"C Coletta","year":"2012","unstructured":"Coletta C, Papapetropoulos A, Erdelyi K, Olah G, M\u00f3dis K, Panopoulos P, Asimakopoulou A, Ger\u00f6 D, Sharina I, Martin E, Szabo C (2012) Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation. Proc Natl Acad Sci USA 109:9161\u20139166. https:\/\/doi.org\/10.1073\/pnas.1202916109","journal-title":"Proc Natl Acad Sci USA"},{"key":"753_CR30","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12916-024-03577-8","volume":"22","author":"EL Connolly","year":"2024","unstructured":"Connolly EL, Liu AH, Radavelli-Bagatini S, Shafaei A, Boyce MC, Wood LG, McCahon L, Koch H, Sim M, Hill CR (2024) Cruciferous vegetables lower blood pressure in adults with mildly elevated blood pressure in a randomized, controlled, crossover trial: the VEgetableS for vaScular hEaLth (VESSEL) study. BMC Med 22:353","journal-title":"BMC Med"},{"key":"753_CR31","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110240","volume":"128","author":"T Cui","year":"2020","unstructured":"Cui T, Liu W, Chen S, Yu C, Li Y, Zhang J-Y (2020) Antihypertensive effects of allicin on spontaneously hypertensive rats via vasorelaxation and hydrogen sulfide mechanisms. Biomed Pharmacother 128:110240","journal-title":"Biomed Pharmacother"},{"key":"753_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.niox.2017.10.010","volume":"81","author":"E Dong\u00f3","year":"2018","unstructured":"Dong\u00f3 E, Beliczai-Marosi G, Dybvig AS, Kiss L (2018) The mechanism of action and role of hydrogen sulfide in the control of vascular tone. Nitric Oxide 81:75\u201387","journal-title":"Nitric Oxide"},{"key":"753_CR33","doi-asserted-by":"publisher","first-page":"363","DOI":"10.3390\/jcm12010363","volume":"12","author":"Z Du","year":"2023","unstructured":"Du Z, Qin Y (2023) Dyslipidemia and cardiovascular disease: current knowledge, existing challenges, and new opportunities for management strategies. J Clin Med 12:363","journal-title":"J Clin Med"},{"key":"753_CR34","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.imr.2016.12.002","volume":"6","author":"H Dubey","year":"2017","unstructured":"Dubey H, Singh A, Patole AM, Tenpe CR (2017) Antihypertensive effect of allicin in dexamethasone-induced hypertensive rats. Integr Med Res 6:60\u201365","journal-title":"Integr Med Res"},{"key":"753_CR35","doi-asserted-by":"publisher","first-page":"4381","DOI":"10.1038\/ncomms5381","volume":"5","author":"M Eberhardt","year":"2014","unstructured":"Eberhardt M, Dux M, Namer B, Miljkovic J, Cordasic N, Will C, Kichko TI, de la Roche J, Fischer M, Su\u00e1rez SA, Bikiel D, Dorsch K, Leffler A, Babes A, Lampert A, Lennerz JK, Jacobi J, Mart\u00ed MA, Doctorovich F, H\u00f6gest\u00e4tt ED, Zygmunt PM, Ivanovic-Burmazovic I, Messlinger K, Reeh P, Filipovic MR (2014) H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun 5:4381. https:\/\/doi.org\/10.1038\/ncomms5381","journal-title":"Nat Commun"},{"key":"753_CR36","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/s0895-7061(00)01298-x","volume":"14","author":"A Elkayam","year":"2001","unstructured":"Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Sadetzki S, Rosenthal T (2001) The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. Am J Hypertens 14:377\u2013381. https:\/\/doi.org\/10.1016\/s0895-7061(00)01298-x","journal-title":"Am J Hypertens"},{"key":"753_CR37","doi-asserted-by":"publisher","first-page":"39613","DOI":"10.1038\/srep39613","volume":"7","author":"A Elosta","year":"2017","unstructured":"Elosta A, Slevin M, Rahman K, Ahmed N (2017) Aged garlic has more potent antiglycation and antioxidant properties compared to fresh garlic extract in vitro. Sci Rep 7:39613","journal-title":"Sci Rep"},{"key":"753_CR38","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1139\/cjpp-2015-0267","volume":"94","author":"AR El-Sheakh","year":"2016","unstructured":"El-Sheakh AR, Ghoneim HA, Suddek GM, Ammar ESM (2016) Attenuation of oxidative stress, inflammation, and endothelial dysfunction in hypercholesterolemic rabbits by allicin. Can J Physiol Pharmacol 94:216\u2013224. https:\/\/doi.org\/10.1139\/cjpp-2015-0267","journal-title":"Can J Physiol Pharmacol"},{"key":"753_CR39","first-page":"3281","volume":"11","author":"L Flori","year":"2023","unstructured":"Flori L, Montanaro R, Pagnotta E, Ugolini L, Righetti L, Martelli A, Di Cesare ML, Ghelardini C, Brancaleone V, Testai L (2023) Erucin exerts cardioprotective effects on ischemia\/reperfusion injury through the modulation of mitoKATP channels. Biomedicine 11:3281","journal-title":"Biomedicine"},{"key":"753_CR40","doi-asserted-by":"publisher","first-page":"543","DOI":"10.3390\/antiox13050543","volume":"13","author":"L Flori","year":"2024","unstructured":"Flori L, Benedetti G, Calderone V, Testai L (2024a) Hydrogen sulfide and irisin, potential allies in ensuring cardiovascular health. Antioxidants 13:543. https:\/\/doi.org\/10.3390\/antiox13050543","journal-title":"Antioxidants"},{"key":"753_CR41","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122491","volume":"341","author":"L Flori","year":"2024","unstructured":"Flori L, Piragine E, Calderone V, Testai L (2024b) Role of hydrogen sulfide in the regulation of lipid metabolism: implications on cardiovascular health. Life Sci 341:122491. https:\/\/doi.org\/10.1016\/j.lfs.2024.122491","journal-title":"Life Sci"},{"key":"753_CR42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/cc9257","volume":"14","author":"F Ganster","year":"2010","unstructured":"Ganster F, Burban M, de La Bourdonnaye M, Fizanne L, Douay O, Loufrani L, Mercat A, Cal\u00e8s P, Radermacher P, Henrion D (2010) Effects of hydrogen sulfide on hemodynamics, inflammatory response and oxidative stress during resuscitated hemorrhagic shock in rats. Crit Care 14:1\u201311","journal-title":"Crit Care"},{"key":"753_CR43","doi-asserted-by":"publisher","first-page":"3850402","DOI":"10.1155\/2016\/3850402","volume":"2016","author":"EM Garc\u00eda-Trejo","year":"2016","unstructured":"Garc\u00eda-Trejo EM, Arellano-Buend\u00eda AS, Arg\u00fcello-Garc\u00eda R, Loredo-Mendoza ML, Garc\u00eda-Arroyo FE, Arellano-Mendoza MG, Castillo-Hern\u00e1ndez MC, Guevara-Balc\u00e1zar G, Tapia E, S\u00e1nchez-Lozada LG (2016) Effects of allicin on hypertension and cardiac function in chronic kidney disease. Oxidative Med Cell Longev 2016:3850402","journal-title":"Oxidative Med Cell Longev"},{"key":"753_CR44","doi-asserted-by":"publisher","first-page":"2641","DOI":"10.1002\/ptr.8183","volume":"38","author":"S Genah","year":"2024","unstructured":"Genah S, Ciccone V, Filippelli A, Simonis V, Martelli A, Piragine E, Pagnotta E, Pecchioni N, Calderone V, Morbidelli L (2024) Erucin, a natural isothiocyanate, exerts pro-angiogenic properties in cultured endothelial cells and reverts angiogenic impairment induced by high glucose. Phytother Res 38:2641\u20132655","journal-title":"Phytother Res"},{"key":"753_CR45","unstructured":"Han C-H, Liu J-C, Chen K-H, Lin Y-S, Chen C-T, Fan C-T, Lee H-L, Liu D-Z, Hou W-C (2011) Antihypertensive activities of processed garlic on spontaneously hypertensive rats and hypertensive humans. Bot Stud 52"},{"key":"753_CR46","doi-asserted-by":"publisher","first-page":"769s","DOI":"10.1093\/jn\/136.3.769S","volume":"136","author":"A Harauma","year":"2006","unstructured":"Harauma A, Moriguchi T (2006) Aged garlic extract improves blood pressure in spontaneously hypertensive rats more safely than raw garlic. J Nutr 136:769s\u2013773s. https:\/\/doi.org\/10.1093\/jn\/136.3.769S","journal-title":"J Nutr"},{"key":"753_CR47","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1124\/jpet.115.227017","volume":"356","author":"ER Hedegaard","year":"2016","unstructured":"Hedegaard ER, Gouliaev A, Winther AK, Arcanjo DD, Aalling M, Renaltan NS, Wood ME, Whiteman M, Skovgaard N, Simonsen U (2016) Involvement of potassium channels and calcium-independent mechanisms in hydrogen sulfide-induced relaxation of rat mesenteric small arteries. J Pharmacol Exp Ther 356:53\u201363. https:\/\/doi.org\/10.1124\/jpet.115.227017","journal-title":"J Pharmacol Exp Ther"},{"key":"753_CR48","first-page":"737","volume-title":"Homocysteine: biochemistry, molecular biology and role in disease","author":"A Hermann","year":"2021","unstructured":"Hermann A, Sitdikova G (2021) Homocysteine: biochemistry, molecular biology and role in disease, vol 11. MDPI, p 737"},{"key":"753_CR49","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1097\/mnh.0000000000000096","volume":"24","author":"KM Holwerda","year":"2015","unstructured":"Holwerda KM, Karumanchi SA, Lely AT (2015) Hydrogen sulfide: role in vascular physiology and pathology. Curr Opin Nephrol Hypertens 24:170\u2013176. https:\/\/doi.org\/10.1097\/mnh.0000000000000096","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"753_CR50","doi-asserted-by":"publisher","first-page":"2001116","DOI":"10.1002\/mnfr.202001116","volume":"65","author":"CN Hsu","year":"2021","unstructured":"Hsu CN, Hou CY, Chang-Chien GP, Lin S, Tain YL (2021) Maternal garlic oil supplementation prevents high-fat diet-induced hypertension in adult rat offspring: implications of H2S-generating pathway in the gut and kidneys. Mol Nutr Food Res 65:2001116","journal-title":"Mol Nutr Food Res"},{"key":"753_CR51","doi-asserted-by":"publisher","first-page":"6797","DOI":"10.1080\/10408398.2022.2043821","volume":"63","author":"VM Imaizumi","year":"2023","unstructured":"Imaizumi VM, Laurindo LF, Manzan B, Guiguer EL, Oshiiwa M, Otoboni AMMB, Araujo AC, Tofano RJ, Barbalho SM (2023) Garlic: a systematic review of the effects on cardiovascular diseases. Crit Rev Food Sci Nutr 63:6797\u20136819","journal-title":"Crit Rev Food Sci Nutr"},{"key":"753_CR52","doi-asserted-by":"publisher","first-page":"9100","DOI":"10.3390\/ijms21239100","volume":"21","author":"JN Jeremic","year":"2020","unstructured":"Jeremic JN, Jakovljevic VL, Zivkovic VI, Srejovic IM, Bradic JV, Milosavljevic IM, Mitrovic SL, Jovicic NU, Bolevich SB, Svistunov AA (2020) Garlic derived diallyl trisulfide in experimental metabolic syndrome: metabolic effects and cardioprotective role. Int J Mol Sci 21:9100","journal-title":"Int J Mol Sci"},{"key":"753_CR53","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1089\/ars.2009.2894","volume":"12","author":"B Jiang","year":"2010","unstructured":"Jiang B, Tang G, Cao K, Wu L, Wang R (2010) Molecular mechanism for H(2)S-induced activation of K(ATP) channels. Antioxid Redox Signal 12:1167\u20131178. https:\/\/doi.org\/10.1089\/ars.2009.2894","journal-title":"Antioxid Redox Signal"},{"key":"753_CR54","doi-asserted-by":"publisher","first-page":"1831","DOI":"10.1177\/1535370217732325","volume":"242","author":"S Jin","year":"2017","unstructured":"Jin S, Teng X, Xiao L, Xue H, Guo Q, Duan X, Chen Y, Wu Y (2017) Hydrogen sulfide ameliorated L-NAME-induced hypertensive heart disease by the Akt\/eNOS\/NO pathway. Exp Biol Med 242:1831\u20131841","journal-title":"Exp Biol Med"},{"key":"753_CR55","doi-asserted-by":"publisher","first-page":"G532","DOI":"10.1152\/ajpgi.00281.2014","volume":"308","author":"M Kang","year":"2015","unstructured":"Kang M, Hashimoto A, Gade A, Akbarali HI (2015) Interaction between hydrogen sulfide-induced sulfhydration and tyrosine nitration in the KATP channel complex. Am J Physiol Gastrointest Liver Physiol 308:G532\u2013G539. https:\/\/doi.org\/10.1152\/ajpgi.00281.2014","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"753_CR56","first-page":"H853","volume":"318","author":"Y Kang","year":"2020","unstructured":"Kang Y, Zhang G, Huang EC, Huang J, Cai J, Cai L, Wang S, Keller BB (2020) Sulforaphane prevents right ventricular injury and reduces pulmonary vascular remodeling in pulmonary arterial hypertension. Am J Phys Heart Circ Phys 318:H853\u2013H866","journal-title":"Am J Phys Heart Circ Phys"},{"key":"753_CR57","first-page":"107","volume":"20","author":"F Kianian","year":"2021","unstructured":"Kianian F, Marefati N, Boskabady M, Ghasemi SZ, Boskabady MH (2021) Pharmacological properties of Allium cepa, preclinical and clinical evidences; a review. Iran J Pharm Res 20:107","journal-title":"Iran J Pharm Res"},{"key":"753_CR58","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00702-016-1600-z","volume":"123","author":"H Kimura","year":"2016","unstructured":"Kimura H (2016) Hydrogen polysulfide (H 2 S n) signaling along with hydrogen sulfide (H 2 S) and nitric oxide (NO). J Neural Transm 123:1235\u20131245","journal-title":"J Neural Transm"},{"key":"753_CR59","doi-asserted-by":"publisher","first-page":"896","DOI":"10.3390\/biom11060896","volume":"11","author":"H Kimura","year":"2021","unstructured":"Kimura H (2021) Hydrogen sulfide (H2S) and polysulfide (H2Sn) signaling: the first 25 years. Biomolecules 11:896","journal-title":"Biomolecules"},{"key":"753_CR60","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1073\/pnas.1321871111","volume":"111","author":"AL King","year":"2014","unstructured":"King AL, Polhemus DJ, Bhushan S, Otsuka H, Kondo K, Nicholson CK, Bradley JM, Islam KN, Calvert JW, Tao YX, Dugas TR, Kelley EE, Elrod JW, Huang PL, Wang R, Lefer DJ (2014) Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent. Proc Natl Acad Sci USA 111:3182\u20133187. https:\/\/doi.org\/10.1073\/pnas.1321871111","journal-title":"Proc Natl Acad Sci USA"},{"key":"753_CR61","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.niox.2013.07.002","volume":"35","author":"GK Kolluru","year":"2013","unstructured":"Kolluru GK, Shen X, Bir SC, Kevil CG (2013) Hydrogen sulfide chemical biology: pathophysiological roles and detection. Nitric Oxide 35:5\u201320. https:\/\/doi.org\/10.1016\/j.niox.2013.07.002","journal-title":"Nitric Oxide"},{"key":"753_CR62","doi-asserted-by":"publisher","first-page":"041","DOI":"10.17352\/2455-2976.000168","volume":"8","author":"OM Kravchuk","year":"2021","unstructured":"Kravchuk OM, Goshovska YV, Korkach YP, Sagach VF, Nagre SW, Bhosle KN (2021) Garlic supplement lowers blood pressure in 40-60 years old hypertensive individuals, regulates oxidative stress, plasma cholesterol and protrombin index. J Cardiovasc Med Cardiol 8:041\u2013047","journal-title":"J Cardiovasc Med Cardiol"},{"key":"753_CR63","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.nut.2012.03.016","volume":"29","author":"VN Larijani","year":"2013","unstructured":"Larijani VN, Ahmadi N, Zeb I, Khan F, Flores F, Budoff M (2013) Beneficial effects of aged garlic extract and coenzyme Q10 on vascular elasticity and endothelial function: the FAITH randomized clinical trial. Nutrition 29:71\u201375. https:\/\/doi.org\/10.1016\/j.nut.2012.03.016","journal-title":"Nutrition"},{"key":"753_CR64","doi-asserted-by":"publisher","first-page":"765s","DOI":"10.1093\/jn\/136.3.765S","volume":"136","author":"BH Lau","year":"2006","unstructured":"Lau BH (2006) Suppression of LDL oxidation by garlic compounds is a possible mechanism of cardiovascular health benefit. J Nutr 136:765s\u2013768s. https:\/\/doi.org\/10.1093\/jn\/136.3.765S","journal-title":"J Nutr"},{"issue":"Suppl 1","key":"753_CR65","doi-asserted-by":"publisher","first-page":"S42","DOI":"10.1002\/mnfr.200900278","volume":"54","author":"YP Lei","year":"2010","unstructured":"Lei YP, Liu CT, Sheen LY, Chen HW, Lii CK (2010) Diallyl disulfide and diallyl trisulfide protect endothelial nitric oxide synthase against damage by oxidized low-density lipoprotein. Mol Nutr Food Res 54(Suppl 1):S42\u2013S52. https:\/\/doi.org\/10.1002\/mnfr.200900278","journal-title":"Mol Nutr Food Res"},{"key":"753_CR66","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.niox.2013.07.001","volume":"35","author":"Q Li","year":"2013","unstructured":"Li Q, Lancaster JR Jr (2013) Chemical foundations of hydrogen sulfide biology. Nitric Oxide 35:21\u201334. https:\/\/doi.org\/10.1016\/j.niox.2013.07.001","journal-title":"Nitric Oxide"},{"key":"753_CR67","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.tips.2007.11.003","volume":"29","author":"L Li","year":"2008","unstructured":"Li L, Moore PK (2008) Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air? Trends Pharmacol Sci 29:84\u201390. https:\/\/doi.org\/10.1016\/j.tips.2007.11.003","journal-title":"Trends Pharmacol Sci"},{"key":"753_CR68","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1146\/annurev-pharmtox-010510-100505","volume":"51","author":"L Li","year":"2011","unstructured":"Li L, Rose P, Moore PK (2011) Hydrogen sulfide and cell signaling. Annu Rev Pharmacol Toxicol 51:169\u2013187. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010510-100505","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"753_CR69","doi-asserted-by":"publisher","first-page":"4196","DOI":"10.1021\/acs.orglett.5b01962","volume":"17","author":"D Liang","year":"2015","unstructured":"Liang D, Wu H, Wong MW, Huang D (2015) Diallyl Trisulfide is a fast H2S donor, but Diallyl Disulfide is a slow one: the reaction pathways and intermediates of glutathione with polysulfides. Org Lett 17:4196\u20134199. https:\/\/doi.org\/10.1021\/acs.orglett.5b01962","journal-title":"Org Lett"},{"key":"753_CR70","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.biopha.2016.07.003","volume":"83","author":"Y Lin","year":"2016","unstructured":"Lin Y, Chen Y, Zhu N, Zhao S, Fan J, Liu E (2016) Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation. Biomed Pharmacother 83:466\u2013476. https:\/\/doi.org\/10.1016\/j.biopha.2016.07.003","journal-title":"Biomed Pharmacother"},{"key":"753_CR71","doi-asserted-by":"publisher","first-page":"5977","DOI":"10.1021\/acs.orglett.9b02117","volume":"21","author":"Y Lin","year":"2019","unstructured":"Lin Y, Yang X, Lu Y, Liang D, Huang D (2019) Isothiocyanates as H2S donors triggered by cysteine: reaction mechanism and structure and activity relationship. Org Lett 21:5977\u20135980","journal-title":"Org Lett"},{"key":"753_CR72","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ejphar.2014.01.010","volume":"725","author":"LL Liu","year":"2014","unstructured":"Liu LL, Yan L, Chen YH, Zeng GH, Zhou Y, Chen HP, Peng WJ, He M, Huang QR (2014) A role for diallyl trisulfide in mitochondrial antioxidative stress contributes to its protective effects against vascular endothelial impairment. Eur J Pharmacol 725:23\u201331. https:\/\/doi.org\/10.1016\/j.ejphar.2014.01.010","journal-title":"Eur J Pharmacol"},{"key":"753_CR73","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113802","volume":"155","author":"W Liu","year":"2022","unstructured":"Liu W, Xu S, Liang S, Duan C, Xu Z, Zhao L, Wen F, Li Q, Li Y, Zhang J (2022) Hypertensive vascular and cardiac remodeling protection by allicin in spontaneous hypertension rats via CaMK II\/NF-\u03baB pathway. Biomed Pharmacother 155:113802","journal-title":"Biomed Pharmacother"},{"key":"753_CR74","doi-asserted-by":"publisher","first-page":"2117","DOI":"10.3390\/nu15092117","volume":"15","author":"S Liu","year":"2023","unstructured":"Liu S, Zhang Y, Zheng X, Wang Z, Wang P, Zhang M, Shen M, Bao Y, Li D (2023) Sulforaphane inhibits foam cell formation and atherosclerosis via mechanisms involving the modulation of macrophage cholesterol transport and the related phenotype. Nutrients 15:2117","journal-title":"Nutrients"},{"key":"753_CR75","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2023.109531","volume":"124","author":"M Lu","year":"2024","unstructured":"Lu M, Pan J, Hu Y, Ding L, Li Y, Cui X, Zhang M, Zhang Z, Li C (2024) Advances in the study of vascular related protective effect of garlic (Allium sativum) extract and compounds. J Nutr Biochem 124:109531","journal-title":"J Nutr Biochem"},{"key":"753_CR76","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1002\/ptr.6159","volume":"32","author":"E Lucarini","year":"2018","unstructured":"Lucarini E, Micheli L, Trallori E, Citi V, Martelli A, Testai L, De Nicola GR, Iori R, Calderone V, Ghelardini C (2018) Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H2S release in vivo. Phytother Res 32:2226\u20132234","journal-title":"Phytother Res"},{"key":"753_CR77","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.phrs.2012.12.005","volume":"70","author":"A Martelli","year":"2013","unstructured":"Martelli A, Testai L, Breschi MC, Lawson K, McKay NG, Miceli F, Taglialatela M, Calderone V (2013a) Vasorelaxation by hydrogen sulphide involves activation of Kv7 potassium channels. Pharmacol Res 70:27\u201334. https:\/\/doi.org\/10.1016\/j.phrs.2012.12.005","journal-title":"Pharmacol Res"},{"key":"753_CR78","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1021\/ml400239a","volume":"4","author":"A Martelli","year":"2013","unstructured":"Martelli A, Testai L, Citi V, Marino A, Pugliesi I, Barresi E, Nesi G, Rapposelli S, Taliani S, Da Settimo F, Breschi MC, Calderone V (2013b) Arylthioamides as H2S donors: l-cysteine-activated releasing properties and vascular effects in vitro and in vivo. ACS Med Chem Lett 4:904\u2013908. https:\/\/doi.org\/10.1021\/ml400239a","journal-title":"ACS Med Chem Lett"},{"key":"753_CR79","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.vph.2013.11.003","volume":"60","author":"A Martelli","year":"2014","unstructured":"Martelli A, Testai L, Citi V, Marino A, Bellagambi FG, Ghimenti S, Breschi MC, Calderone V (2014) Pharmacological characterization of the vascular effects of aryl isothiocyanates: is hydrogen sulfide the real player? Vasc Pharmacol 60:32\u201341","journal-title":"Vasc Pharmacol"},{"key":"753_CR80","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1089\/ars.2019.7888","volume":"32","author":"A Martelli","year":"2020","unstructured":"Martelli A, Citi V, Testai L, Brogi S, Calderone V (2020a) Organic isothiocyanates as hydrogen sulfide donors. Antioxid Redox Signal 32:110\u2013144","journal-title":"Antioxid Redox Signal"},{"key":"753_CR81","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1111\/bph.14645","volume":"177","author":"A Martelli","year":"2020","unstructured":"Martelli A, Piragine E, Citi V, Testai L, Pagnotta E, Ugolini L, Lazzeri L, Di Cesare Mannelli L, Manzo OL, Bucci M (2020b) Erucin exhibits vasorelaxing effects and antihypertensive activity by H2S-releasing properties. Br J Pharmacol 177:824\u2013835","journal-title":"Br J Pharmacol"},{"key":"753_CR82","doi-asserted-by":"publisher","first-page":"961","DOI":"10.3390\/antiox10060961","volume":"10","author":"A Martelli","year":"2021","unstructured":"Martelli A, Piragine E, Gorica E, Citi V, Testai L, Pagnotta E, Lazzeri L, Pecchioni N, Ciccone V, Montanaro R (2021) The H2S-donor erucin exhibits protective effects against vascular inflammation in human endothelial and smooth muscle cells. Antioxidants 10:961","journal-title":"Antioxidants"},{"key":"753_CR83","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106947","volume":"196","author":"A Martelli","year":"2023","unstructured":"Martelli A, di Villa Bianca RE, Cirino G, Sorrentino R, Calderone V, Bucci M (2023) Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: classification, differences and relevance in preclinical and clinical studies. Pharmacol Res 196:106947","journal-title":"Pharmacol Res"},{"key":"753_CR84","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1016\/j.numecd.2016.04.008","volume":"26","author":"T Matsui","year":"2016","unstructured":"Matsui T, Nakamura N, Ojima A, Nishino Y, Yamagishi SI (2016) Sulforaphane reduces advanced glycation end products (AGEs)-induced inflammation in endothelial cells and rat aorta. Nutr Metab Cardiovasc Dis 26:797\u2013807. https:\/\/doi.org\/10.1016\/j.numecd.2016.04.008","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"753_CR85","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.568861","volume":"11","author":"T Meng","year":"2020","unstructured":"Meng T, Qin W, Liu B (2020) SIRT1 antagonizes oxidative stress in diabetic vascular complication. Front Endocrinol 11:568861","journal-title":"Front Endocrinol"},{"key":"753_CR86","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1002\/biof.5520220154","volume":"22","author":"M Murashima","year":"2004","unstructured":"Murashima M, Watanabe S, Zhuo XG, Uehara M, Kurashige A (2004) Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one-week intake of broccoli sprouts. Biofactors 22:271\u2013275. https:\/\/doi.org\/10.1002\/biof.5520220154","journal-title":"Biofactors"},{"key":"753_CR87","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1161\/circresaha.111.240242","volume":"109","author":"AK Mustafa","year":"2011","unstructured":"Mustafa AK, Sikka G, Gazi SK, Steppan J, Jung SM, Bhunia AK, Barodka VM, Gazi FK, Barrow RK, Wang R, Amzel LM, Berkowitz DE, Snyder SH (2011) Hydrogen sulfide as endothelium-derived hyperpolarizing factor sulfhydrates potassium channels. Circ Res 109:1259\u20131268. https:\/\/doi.org\/10.1161\/circresaha.111.240242","journal-title":"Circ Res"},{"key":"753_CR88","first-page":"H1437","volume":"311","author":"JS Naik","year":"2016","unstructured":"Naik JS, Osmond JM, Walker BR, Kanagy NL (2016) Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels. Am J Phys Heart Circ Phys 311:H1437\u2013H1444","journal-title":"Am J Phys Heart Circ Phys"},{"key":"753_CR89","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1016\/j.jnutbio.2014.03.011","volume":"25","author":"P Nallasamy","year":"2014","unstructured":"Nallasamy P, Si H, Babu PV, Pan D, Fu Y, Brooke EA, Shah H, Zhen W, Zhu H, Liu D, Li Y, Jia Z (2014) Sulforaphane reduces vascular inflammation in mice and prevents TNF-\u03b1-induced monocyte adhesion to primary endothelial cells through interfering with the NF-\u03baB pathway. J Nutr Biochem 25:824\u2013833. https:\/\/doi.org\/10.1016\/j.jnutbio.2014.03.011","journal-title":"J Nutr Biochem"},{"key":"753_CR90","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.3923\/pjbs.2008.1569.1575","volume":"11","author":"MK Naseri","year":"2008","unstructured":"Naseri MK, Arabian M, Badavi M, Ahangarpour A (2008) Vasorelaxant and hypotensive effects of Allium cepa peel hydroalcoholic extract in rat. Pak J Biol Sci 11:1569\u20131575. https:\/\/doi.org\/10.3923\/pjbs.2008.1569.1575","journal-title":"Pak J Biol Sci"},{"key":"753_CR91","first-page":"213","volume":"26","author":"CR Nwokocha","year":"2011","unstructured":"Nwokocha CR, Ozolua RI, Owu DU, Nwokocha MI, Ugwu AC (2011) Antihypertensive properties of Allium sativum (garlic) on normotensive and two kidney one clip hypertensive rats. Niger J Physiol Sci 26:213\u2013218","journal-title":"Niger J Physiol Sci"},{"key":"753_CR92","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094228","volume":"9","author":"R Padiya","year":"2014","unstructured":"Padiya R, Chowdhury D, Borkar R, Srinivas R, Pal Bhadra M, Banerjee SK (2014) Garlic attenuates cardiac oxidative stress via activation of PI3K\/AKT\/Nrf2-Keap1 pathway in fructose-fed diabetic rat. PLoS One 9:e94228. https:\/\/doi.org\/10.1371\/journal.pone.0094228","journal-title":"PLoS One"},{"key":"753_CR93","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109182","volume":"111","author":"J Pan","year":"2023","unstructured":"Pan J, Wang R, Pei Y, Wang D, Wu N, Ji Y, Tang Q, Liu L, Cheng K, Liu Q (2023) Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension via inhibiting inflammation and oxidative stress. J Nutr Biochem 111:109182","journal-title":"J Nutr Biochem"},{"key":"753_CR94","doi-asserted-by":"publisher","first-page":"581","DOI":"10.3390\/biom12040581","volume":"12","author":"E Piragine","year":"2022","unstructured":"Piragine E, Citi V, Lawson K, Calderone V, Martelli A (2022a) Potential effects of natural H2S-donors in hypertension management. Biomolecules 12:581","journal-title":"Biomolecules"},{"key":"753_CR95","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106519","volume":"185","author":"E Piragine","year":"2022","unstructured":"Piragine E, Petri D, Giometto S, Martelli A, Lucenteforte E, Calderone V (2022b) Potential effects of Alliaceae and Brassicaceae edible plants on blood glucose levels in patients with type 2 diabetes: a systematic review and meta-analysis of clinical trials. Pharmacol Res 185:106519","journal-title":"Pharmacol Res"},{"key":"753_CR96","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.3390\/biom13071023","volume":"13","author":"E Piragine","year":"2023","unstructured":"Piragine E, Malanima MA, Lucenteforte E, Martelli A, Calderone V (2023) Circulating levels of hydrogen sulfide (H2S) in patients with age-related diseases: a systematic review and meta-analysis. Biomolecules 13:1023","journal-title":"Biomolecules"},{"key":"753_CR97","doi-asserted-by":"crossref","unstructured":"Piragine E, Malanima MA, Ceccanti C, Guidi L, Martelli A, Lucenteforte E, Calderone V (2024) Alliaceae versus Brassicaceae for Dyslipidemia: state of the art and future perspectives. Systematic review and meta-analysis of clinical studies. Phytother Res","DOI":"10.1002\/ptr.8350"},{"key":"753_CR98","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1111\/bph.14514","volume":"176","author":"G Pozsgai","year":"2019","unstructured":"Pozsgai G, B\u00e1tai IZ, Pint\u00e9r E (2019) Effects of sulfide and polysulfides transmitted by direct or signal transduction-mediated activation of TRPA1 channels. Br J Pharmacol 176:628\u2013645","journal-title":"Br J Pharmacol"},{"key":"753_CR99","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/bs.afnr.2019.02.008","volume":"90","author":"M Prieto","year":"2019","unstructured":"Prieto M, L\u00f3pez CJ, Simal-Gandara J (2019) Glucosinolates: molecular structure, breakdown, genetic, bioavailability, properties and healthy and adverse effects. Adv Food Nutr Res 90:305\u2013350","journal-title":"Adv Food Nutr Res"},{"issue":"4","key":"753_CR100","first-page":"139","volume":"45","author":"E Rahmatinia","year":"2024","unstructured":"Rahmatinia E, Amidi B, Naderi N, Ahmadipour S, Ahmadvand H, Pahlevan-Fallahy M-T, Ghorbanzadeh V, Nazari A (2024) Randomized, double-blind clinical trial evaluating the impact of freeze-dried garlic extract capsules on blood pressure, lipid profile, and nitric oxide levels in individuals at risk for hypertension. Horm Mol Biol Clin Invest 45(4):139\u2013147","journal-title":"Horm Mol Biol Clin Invest"},{"key":"753_CR101","doi-asserted-by":"publisher","first-page":"1558","DOI":"10.3390\/foods12071558","volume":"12","author":"L Recinella","year":"2023","unstructured":"Recinella L, Libero ML, Citi V, Chiavaroli A, Martelli A, Foligni R, Mannozzi C, Acquaviva A, Di Simone S, Calderone V (2023) Anti-inflammatory and vasorelaxant effects induced by an aqueous aged black garlic extract supplemented with vitamins D, C, and B12 on cardiovascular system. Foods 12:1558","journal-title":"Foods"},{"key":"753_CR102","first-page":"1472","volume":"19","author":"K Ried","year":"2020","unstructured":"Ried K (2020) Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: a review and meta-analysis. Exp Ther Med 19:1472\u20131478","journal-title":"Exp Ther Med"},{"key":"753_CR103","doi-asserted-by":"publisher","first-page":"122","DOI":"10.3389\/fnut.2018.00122","volume":"5","author":"K Ried","year":"2018","unstructured":"Ried K, Travica N, Sali A (2018) The effect of kyolic aged garlic extract on gut microbiota, inflammation, and cardiovascular markers in hypertensives: the GarGIC trial. Front Nutr 5:122","journal-title":"Front Nutr"},{"key":"753_CR104","doi-asserted-by":"publisher","first-page":"295","DOI":"10.3390\/nu11020295","volume":"11","author":"C Rodrigues","year":"2019","unstructured":"Rodrigues C, Percival SS (2019) Immunomodulatory effects of glutathione, garlic derivatives, and hydrogen sulfide. Nutrients 11:295","journal-title":"Nutrients"},{"key":"753_CR105","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1271\/bbb.67.1305","volume":"67","author":"Y Sakai","year":"2003","unstructured":"Sakai Y, Murakami T, Yamamoto Y (2003) Antihypertensive effects of onion on NO synthase inhibitor-induced hypertensive rats and spontaneously hypertensive rats. Biosci Biotechnol Biochem 67:1305\u20131311. https:\/\/doi.org\/10.1271\/bbb.67.1305","journal-title":"Biosci Biotechnol Biochem"},{"key":"753_CR106","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1002\/(sici)1097-010x(19981015)282:3<310::aid-jez4>3.0.co;2-p","volume":"282","author":"DG Searcy","year":"1998","unstructured":"Searcy DG, Lee SH (1998) Sulfur reduction by human erythrocytes. J Exp Zool 282:310\u2013322. https:\/\/doi.org\/10.1002\/(sici)1097-010x(19981015)282:3<310::aid-jez4>3.0.co;2-p","journal-title":"J Exp Zool"},{"key":"753_CR107","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1038\/ajh.2011.200","volume":"25","author":"GV Senanayake","year":"2012","unstructured":"Senanayake GV, Banigesh A, Wu L, Lee P, Juurlink BH (2012) The dietary phase 2 protein inducer sulforaphane can normalize the kidney epigenome and improve blood pressure in hypertensive rats. Am J Hypertens 25:229\u2013235. https:\/\/doi.org\/10.1038\/ajh.2011.200","journal-title":"Am J Hypertens"},{"key":"753_CR108","doi-asserted-by":"publisher","first-page":"3691","DOI":"10.3390\/nu15173691","volume":"15","author":"JC Serrano","year":"2023","unstructured":"Serrano JC, Castro-Boqu\u00e9 E, Garc\u00eda-Carrasco A, Mor\u00e1n-Valero MI, Gonz\u00e1lez-Hedstr\u00f6m D, Berm\u00fadez-L\u00f3pez M, Valdivielso JM, Espinel AE, Portero-Ot\u00edn M (2023) Antihypertensive effects of an optimized aged garlic extract in subjects with Grade I hypertension and antihypertensive drug therapy: a randomized, triple-blind controlled trial. Nutrients 15:3691","journal-title":"Nutrients"},{"key":"753_CR109","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1016\/j.ejmech.2017.10.068","volume":"143","author":"B Severino","year":"2018","unstructured":"Severino B, Corvino A, Fiorino F, Luciano P, Frecentese F, Magli E, Saccone I, Di Vaio P, Citi V, Calderone V (2018) 1, 2, 4-Thiadiazolidin-3, 5-diones as novel hydrogen sulfide donors. Eur J Med Chem 143:1677\u20131686","journal-title":"Eur J Med Chem"},{"key":"753_CR110","first-page":"1457","volume":"19","author":"K Shaikh","year":"2020","unstructured":"Shaikh K, Kinninger A, Cherukuri L, Birudaraju D, Nakanishi R, Almeida S, Jayawardena E, Shekar C, Flores F, Hamal S (2020) Aged garlic extract reduces low attenuation plaque in coronary arteries of patients with diabetes: a randomized, double-blind, placebo-controlled study. Exp Ther Med 19:1457\u20131461","journal-title":"Exp Ther Med"},{"key":"753_CR111","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/s0378-8741(03)00080-1","volume":"86","author":"AM Sharifi","year":"2003","unstructured":"Sharifi AM, Darabi R, Akbarloo N (2003) Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat. J Ethnopharmacol 86:219\u2013224. https:\/\/doi.org\/10.1016\/s0378-8741(03)00080-1","journal-title":"J Ethnopharmacol"},{"key":"753_CR112","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.etap.2018.12.008","volume":"66","author":"NM Shawky","year":"2019","unstructured":"Shawky NM, Shehatou GS, Suddek GM, Gameil NM (2019) Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats. Environ Toxicol Pharmacol 66:43\u201354","journal-title":"Environ Toxicol Pharmacol"},{"key":"753_CR113","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.vph.2015.03.005","volume":"71","author":"HN Siti","year":"2015","unstructured":"Siti HN, Kamisah Y, Kamsiah J (2015) The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review). Vasc Pharmacol 71:40\u201356. https:\/\/doi.org\/10.1016\/j.vph.2015.03.005","journal-title":"Vasc Pharmacol"},{"key":"753_CR114","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.phymed.2015.10.014","volume":"23","author":"IA Sobenin","year":"2016","unstructured":"Sobenin IA, Andrianova IV, Lakunin KY, Karagodin VP, Bobryshev YV, Orekhov AN (2016) Anti-atherosclerotic effects of garlic preparation in freeze injury model of atherosclerosis in cholesterol-fed rabbits. Phytomedicine 23:1235\u20131239. https:\/\/doi.org\/10.1016\/j.phymed.2015.10.014","journal-title":"Phytomedicine"},{"key":"753_CR115","doi-asserted-by":"publisher","first-page":"2388","DOI":"10.1002\/ptr.8181","volume":"38","author":"J Spezzini","year":"2024","unstructured":"Spezzini J, Piragine E, Flori L, Calderone V, Martelli A (2024) Natural H2S-donors: a new pharmacological opportunity for the management of overweight and obesity. Phytother Res 38:2388\u20132405","journal-title":"Phytother Res"},{"key":"753_CR116","doi-asserted-by":"publisher","first-page":"H2431","DOI":"10.1152\/ajpheart.00384.2006","volume":"291","author":"X Sun","year":"2006","unstructured":"Sun X, Ku DD (2006) Allicin in garlic protects against coronary endothelial dysfunction and right heart hypertrophy in pulmonary hypertensive rats. Am J Physiol Heart Circ Physiol 291:H2431\u2013H2438. https:\/\/doi.org\/10.1152\/ajpheart.00384.2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"753_CR117","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.biochi.2022.04.013","volume":"199","author":"D Szl\u0119zak","year":"2022","unstructured":"Szl\u0119zak D, Hutsch T, Ufnal M, Wr\u00f3bel M (2022) Heart and kidney H2S production is reduced in hypertensive and older rats. Biochimie 199:130\u2013138","journal-title":"Biochimie"},{"key":"753_CR118","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1016\/j.biopha.2018.03.131","volume":"102","author":"M Szuli\u0144ska","year":"2018","unstructured":"Szuli\u0144ska M, Kr\u0119gielska-Naro\u017cna M, \u015awi\u0105tek J, Sty\u015b P, Ku\u017anar-Kami\u0144ska B, Jakubowski H, Walkowiak J, Bogda\u0144ski P (2018) Garlic extract favorably modifies markers of endothelial function in obese patients\u2013randomized double blind placebo-controlled nutritional intervention. Biomed Pharmacother 102:792\u2013797","journal-title":"Biomed Pharmacother"},{"key":"753_CR119","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.phrs.2016.09.006","volume":"113","author":"L Testai","year":"2016","unstructured":"Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Mannelli LDC, Martelli A, Citi V, Breschi MC, Levi R (2016) The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia\/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. Pharmacol Res 113:290\u2013299","journal-title":"Pharmacol Res"},{"key":"753_CR120","doi-asserted-by":"publisher","first-page":"910","DOI":"10.3390\/antiox10060910","volume":"10","author":"L Testai","year":"2021","unstructured":"Testai L, Brancaleone V, Flori L, Montanaro R, Calderone V (2021) Modulation of EndMT by hydrogen sulfide in the prevention of cardiovascular fibrosis. Antioxidants 10:910","journal-title":"Antioxidants"},{"key":"753_CR121","doi-asserted-by":"publisher","first-page":"2616","DOI":"10.1002\/ptr.7479","volume":"36","author":"L Testai","year":"2022","unstructured":"Testai L, Pagnotta E, Piragine E, Flori L, Citi V, Martelli A, Mannelli LDC, Ghelardini C, Matteo R, Suriano S (2022) Cardiovascular benefits of Eruca sativa mill. Defatted seed meal extract: potential role of hydrogen sulfide. Phytother Res 36:2616\u20132627","journal-title":"Phytother Res"},{"key":"753_CR122","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115728","volume":"215","author":"L Testai","year":"2023","unstructured":"Testai L, Montanaro R, Flori L, Pagnotta E, Vellecco V, Gorica E, Ugolini L, Righetti L, Brancaleone V, Bucci M (2023) Persulfidation of mitoKv7. 4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia\/reperfusion injury. Biochem Pharmacol 215:115728","journal-title":"Biochem Pharmacol"},{"key":"753_CR123","doi-asserted-by":"publisher","first-page":"3435","DOI":"10.3390\/foods11213435","volume":"11","author":"FS Thomaz","year":"2022","unstructured":"Thomaz FS, Tan YP, Williams CM, Ward LC, Worrall S, Panchal SK (2022) Wasabi (eutrema japonicum) reduces obesity and blood pressure in diet-induced metabolic syndrome in rats. Foods 11:3435","journal-title":"Foods"},{"key":"753_CR124","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jare.2020.06.005","volume":"27","author":"D Tian","year":"2021","unstructured":"Tian D, Teng X, Jin S, Chen Y, Xue H, Xiao L, Wu Y (2021) Endogenous hydrogen sulfide improves vascular remodeling through PPAR\u03b4\/SOCS3 signaling. J Adv Res 27:115\u2013125","journal-title":"J Adv Res"},{"key":"753_CR125","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.niox.2014.12.012","volume":"46","author":"L Tomasova","year":"2015","unstructured":"Tomasova L, Pavlovicova M, Malekova L, Misak A, Kristek F, Grman M, Cacanyiova S, Tomasek M, Tomaskova Z, Perry A (2015) Effects of AP39, a novel triphenylphosphonium derivatised anethole dithiolethione hydrogen sulfide donor, on rat haemodynamic parameters and chloride and calcium Cav3 and RyR2 channels. Nitric Oxide 46:131\u2013144","journal-title":"Nitric Oxide"},{"key":"753_CR126","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116960","volume":"318","author":"S Varade","year":"2024","unstructured":"Varade S, Nadella M, Hirake A, Bhausaheb Mungase S, Ali A, Adela R (2024) Effect of garlic on the components of metabolic syndrome: a systematic review and meta-analysis of randomized controlled trials. J Ethnopharmacol 318:116960","journal-title":"J Ethnopharmacol"},{"key":"753_CR127","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/475216","volume":"2011","author":"MA Vazquez-Prieto","year":"2011","unstructured":"Vazquez-Prieto MA, Rodriguez Lanzi C, Lembo C, Galmarini CR, Miatello RM (2011) Garlic and onion attenuates vascular inflammation and oxidative stress in fructose-fed rats. J Nutr Metab 2011:475216. https:\/\/doi.org\/10.1155\/2011\/475216","journal-title":"J Nutr Metab"},{"key":"753_CR128","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1152\/physrev.00017.2011","volume":"92","author":"R Wang","year":"2012","unstructured":"Wang R (2012) Physiological implications of hydrogen sulfide: a whiff exploration that blossomed. Physiol Rev 92:791\u2013896. https:\/\/doi.org\/10.1152\/physrev.00017.2011","journal-title":"Physiol Rev"},{"key":"753_CR129","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1161\/HYPERTENSIONAHA.122.19456","volume":"80","author":"R Wang","year":"2023","unstructured":"Wang R (2023) Roles of hydrogen sulfide in hypertension development and its complications: what, so what, now what. Hypertension 80:936\u2013944","journal-title":"Hypertension"},{"key":"753_CR130","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1161\/atvbaha.108.179333","volume":"29","author":"Y Wang","year":"2009","unstructured":"Wang Y, Zhao X, Jin H, Wei H, Li W, Bu D, Tang X, Ren Y, Tang C, Du J (2009) Role of hydrogen sulfide in the development of atherosclerotic lesions in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol 29:173\u2013179. https:\/\/doi.org\/10.1161\/atvbaha.108.179333","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"753_CR131","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1016\/j.tips.2015.05.007","volume":"36","author":"R Wang","year":"2015","unstructured":"Wang R, Szabo C, Ichinose F, Ahmed A, Whiteman M, Papapetropoulos A (2015) The role of H2S bioavailability in endothelial dysfunction. Trends Pharmacol Sci 36:568\u2013578","journal-title":"Trends Pharmacol Sci"},{"key":"753_CR132","doi-asserted-by":"publisher","first-page":"750s","DOI":"10.1093\/jn\/136.3.750S","volume":"136","author":"N Weiss","year":"2006","unstructured":"Weiss N, Ide N, Abahji T, Nill L, Keller C, Hoffmann U (2006) Aged garlic extract improves homocysteine-induced endothelial dysfunction in macro- and microcirculation. J Nutr 136:750s\u2013754s. https:\/\/doi.org\/10.1093\/jn\/136.3.750S","journal-title":"J Nutr"},{"key":"753_CR133","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1002\/ptr.1663","volume":"19","author":"MJ Williams","year":"2005","unstructured":"Williams MJ, Sutherland WH, McCormick MP, Yeoman DJ, de Jong SA (2005) Aged garlic extract improves endothelial function in men with coronary artery disease. Phytother Res 19:314\u2013319. https:\/\/doi.org\/10.1002\/ptr.1663","journal-title":"Phytother Res"},{"key":"753_CR134","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s0024-3205(02)01708-3","volume":"71","author":"RK Wilson","year":"2002","unstructured":"Wilson RK, Kwan TK, Kwan CY, Sorger GJ (2002) Effects of papaya seed extract and benzyl isothiocyanate on vascular contraction. Life Sci 71:497\u2013507. https:\/\/doi.org\/10.1016\/s0024-3205(02)01708-3","journal-title":"Life Sci"},{"key":"753_CR135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12906-020-02932-5","volume":"20","author":"M Wlosinska","year":"2020","unstructured":"Wlosinska M, Nilsson A-C, Hlebowicz J, Hauggaard A, Kjellin M, Fakhro M, Lindstedt S (2020) The effect of aged garlic extract on the atherosclerotic process\u2013a randomized double-blind placebo-controlled trial. BMC Complement Med Ther 20:1\u201310","journal-title":"BMC Complement Med Ther"},{"key":"753_CR136","doi-asserted-by":"publisher","first-page":"3171","DOI":"10.2337\/db16-0020","volume":"65","author":"L Xie","year":"2016","unstructured":"Xie L, Gu Y, Wen M, Zhao S, Wang W, Ma Y, Meng G, Han Y, Wang Y, Liu G, Moore PK, Wang X, Wang H, Zhang Z, Yu Y, Ferro A, Huang Z, Ji Y (2016a) Hydrogen sulfide induces Keap1 S-sulfhydration and suppresses diabetes-accelerated atherosclerosis via Nrf2 activation. Diabetes 65:3171\u20133184. https:\/\/doi.org\/10.2337\/db16-0020","journal-title":"Diabetes"},{"key":"753_CR137","doi-asserted-by":"publisher","first-page":"6043038","DOI":"10.1155\/2016\/6043038","volume":"2016","author":"ZZ Xie","year":"2016","unstructured":"Xie ZZ, Liu Y, Bian JS (2016b) Hydrogen sulfide and cellular redox homeostasis. Oxidative Med Cell Longev 2016:6043038. https:\/\/doi.org\/10.1155\/2016\/6043038","journal-title":"Oxidative Med Cell Longev"},{"key":"753_CR138","doi-asserted-by":"publisher","first-page":"2329","DOI":"10.3109\/13880209.2016.1138314","volume":"54","author":"S Yamagishi","year":"2016","unstructured":"Yamagishi S, Matsui T (2016) Protective role of sulphoraphane against vascular complications in diabetes. Pharm Biol 54:2329\u20132339. https:\/\/doi.org\/10.3109\/13880209.2016.1138314","journal-title":"Pharm Biol"},{"key":"753_CR139","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1016\/j.fct.2013.04.001","volume":"57","author":"L Yi","year":"2013","unstructured":"Yi L, Su Q (2013) Molecular mechanisms for the anti-cancer effects of diallyl disulfide. Food Chem Toxicol 57:362\u2013370. https:\/\/doi.org\/10.1016\/j.fct.2013.04.001","journal-title":"Food Chem Toxicol"},{"key":"753_CR140","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.102941","volume":"88","author":"E Zaorska","year":"2019","unstructured":"Zaorska E, Hutsch T, Gawry\u015b-Kopczy\u0144ska M, Ostaszewski R, Ufnal M, Koszelewski D (2019) Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure. Bioorg Chem 88:102941","journal-title":"Bioorg Chem"},{"key":"753_CR141","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113273","volume":"152","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wu Q, Liu J, Zhang Z, Ma X, Zhang Y, Zhu J, Thring RW, Wu M, Gao Y (2022) Sulforaphane alleviates high fat diet-induced insulin resistance via AMPK\/Nrf2\/GPx4 axis. Biomed Pharmacother 152:113273","journal-title":"Biomed Pharmacother"},{"key":"753_CR142","doi-asserted-by":"publisher","first-page":"6008","DOI":"10.1093\/emboj\/20.21.6008","volume":"20","author":"W Zhao","year":"2001","unstructured":"Zhao W, Zhang J, Lu Y, Wang R (2001) The vasorelaxant effect of H(2)S as a novel endogenous gaseous K(ATP) channel opener. EMBO J 20:6008\u20136016. https:\/\/doi.org\/10.1093\/emboj\/20.21.6008","journal-title":"EMBO J"},{"key":"753_CR143","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1016\/j.phrs.2016.06.029","volume":"111","author":"Z Zhou","year":"2016","unstructured":"Zhou Z, Martin E, Sharina I, Esposito I, Szabo C, Bucci M, Cirino G, Papapetropoulos A (2016) Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide. Pharmacol Res 111:556\u2013562. https:\/\/doi.org\/10.1016\/j.phrs.2016.06.029","journal-title":"Pharmacol Res"},{"key":"753_CR144","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118831","volume":"267","author":"M-L Zhu","year":"2021","unstructured":"Zhu M-L, Zhao F-R, Zhu T-T, Wang Q-Q, Wu Z-Q, Song P, Xu J, Wan G-R, Yin Y-L, Li P (2021) The antihypertension effect of hydrogen sulfide (H2S) is induced by activating VEGFR2 signaling pathway. Life Sci 267:118831","journal-title":"Life Sci"}],"container-title":["Handbook of Experimental Pharmacology","Hydrogen Sulfide: A Toxicant with Healing Potential"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2025_753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:02:56Z","timestamp":1777064576000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2025_753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783032244314","9783032244321"],"references-count":144,"URL":"https:\/\/doi.org\/10.1007\/164_2025_753","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"8 October 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}