{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:40:21Z","timestamp":1777066821068,"version":"3.51.4"},"publisher-location":"Cham","reference-count":112,"publisher":"Springer Nature Switzerland","isbn-type":[{"value":"9783032244314","type":"print"},{"value":"9783032244321","type":"electronic"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/164_2025_755","type":"book-chapter","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T17:57:35Z","timestamp":1760464655000},"page":"123-146","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Hydrogen Sulfide-Derived Perivascular Adipose Tissue in Vascular Diseases"],"prefix":"10.1007","author":[{"given":"Emma","family":"Mitidieri","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Indolfi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Brancaleone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Sorrentino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"d\u2019Emmanuele di Villa Bianca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"755_CR1","doi-asserted-by":"publisher","first-page":"4747","DOI":"10.1113\/JP271006","volume":"593","author":"F Aalbaek","year":"2015","unstructured":"Aalbaek F, Bonde L, Kim S, Boedtkjer E (2015) The Journal of Physiology Perivascular tissue inhibits rho-kinase-dependent smooth muscle Ca2+ sensitivity and endothelium-dependent H2S signalling in rat coronary arteries. J Physiol 593:4747\u20134764","journal-title":"J Physiol"},{"key":"755_CR2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.613989","volume":"12","author":"S Abramavicius","year":"2021","unstructured":"Abramavicius S, Petersen AG, Renaltan NS, Prat-Duran J, Torregrossa R, Stankevicius E, Whiteman M, Simonsen U (2021) GYY4137 and sodium hydrogen sulfide relaxations are inhibited by L-cysteine and KV7 channel blockers in rat small mesenteric arteries. Front Pharmacol 12:613989","journal-title":"Front Pharmacol"},{"key":"755_CR3","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.3390\/cells12081196","volume":"12","author":"A Ahmed","year":"2023","unstructured":"Ahmed A, Bibi A, Valoti M, Fusi F (2023) Perivascular adipose tissue and vascular smooth muscle tone: friends or foes? Cells 12:1196","journal-title":"Cells"},{"key":"755_CR4","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/bph.12479","volume":"171","author":"TA Almabrouk","year":"2014","unstructured":"Almabrouk TA, Ewart MA, Salt IP, Kennedy S (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases. Br J Pharmacol 171:595\u2013617","journal-title":"Br J Pharmacol"},{"issue":"44","key":"755_CR5","doi-asserted-by":"publisher","first-page":"3827","DOI":"10.1093\/eurheartj\/ehad484","volume":"12","author":"C Antoniades","year":"2023","unstructured":"Antoniades C, Tousoulis D, Vavlukis M, Fleming I, Duncker DJ, Eringa E, Manfrini O, Antonopoulos AS, Oikonomou E, Padr\u00f3 T, Trifunovic-Zamaklar D, De Luca G, Guzik T, Cenko E, Djordjevic-Dikic A, Crea F (2023) Perivascular adipose tissue as a source of therapeutic targets and clinical biomarkers. Eur Heart J 12(44):3827\u20133844","journal-title":"Eur Heart J"},{"key":"755_CR6","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1006\/bbrc.1999.0255","volume":"257","author":"Y Arita","year":"1999","unstructured":"Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257:79\u201383","journal-title":"Biochem Biophys Res Commun"},{"key":"755_CR7","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1111\/bph.12171","volume":"169","author":"A Asimakopoulou","year":"2013","unstructured":"Asimakopoulou A, Panopoulos P, Chasapis CT, Coletta C, Zhou Z, Cirino G, Giannis A, Szabo C, Spyroulias GA, Papapetropoulos A (2013) Selectivity of commonly used pharmacological inhibitors for cystathionine \u03b2 synthase (CBS) and cystathionine \u03b3 lyase (CSE). Br J Pharmacol 169:922\u2013932","journal-title":"Br J Pharmacol"},{"key":"755_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12872-016-0320-5","volume":"16","author":"T Auguet","year":"2016","unstructured":"Auguet T, Aragones G, Guiu-Jurado E, Berlanga A, Curriu M, Martinez S, Alibalic A, Aguilar C, Camara M-L, Hern\u00e0ndez E, Ruyra X, Martin-Paredero V, Richart C (2016) Adipo\/cytokines in atherosclerotic secretomes: increased visfatin levels in unstable carotid plaque. BMC Cardiovasc Disord 16:149","journal-title":"BMC Cardiovasc Disord"},{"key":"755_CR9","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1139\/cjpp-2013-0001","volume":"91","author":"J Be\u0142towski","year":"2013","unstructured":"Be\u0142towski J (2013) Endogenous hydrogen sulfide in perivascular adipose tissue: role in the regulation of vascular tone in physiology and pathology. Can J Physiol Pharmacol 91:889\u2013898","journal-title":"Can J Physiol Pharmacol"},{"issue":"1","key":"755_CR10","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.04.107","volume":"241","author":"J Beltowski","year":"2015","unstructured":"Beltowski J (2015) High fat diet-induced obesity augments H2S in perivascular adipose tissue by cannabinoid-mediated decrease in mitochondrial biogenesis; Proceedings of the 83rd Congress of European Atherosclerosis Society. Atherosclerosis 241(1):e28","journal-title":"Atherosclerosis"},{"key":"755_CR11","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1089\/ars.2011.4358","volume":"17","author":"J Be\u0142towski","year":"2012","unstructured":"Be\u0142towski J, Jamroz-Wi\u015bniewska A (2012) Modulation of h(2)s metabolism by statins: a new aspect of cardiovascular pharmacology. Antioxid Redox Signal 17:81\u201394","journal-title":"Antioxid Redox Signal"},{"key":"755_CR12","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3390\/molecules22010063","volume":"22","author":"J Be\u0142towski","year":"2016","unstructured":"Be\u0142towski J, Jamroz-Wi\u015bniewska A (2016) Hydrogen sulfide in the adipose tissue-physiology, pathology and a target for pharmacotherapy. Molecules 22:63","journal-title":"Molecules"},{"key":"755_CR13","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1139\/cjpp-2014-0543","volume":"93","author":"J Be\u0142towski","year":"2015","unstructured":"Be\u0142towski J, Guranowski A, Jamroz-Wi\u015bniewska A, Wolski A, Ha\u0142as K (2015) Hydrogen-sulfide-mediated vasodilatory effect of nucleoside 5\u2032-monophosphorothioates in perivascular adipose tissue. Can J Physiol Pharmacol 93:585\u2013595","journal-title":"Can J Physiol Pharmacol"},{"key":"755_CR14","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.atherosclerosis.2005.02.014","volume":"182","author":"MS Burnett","year":"2005","unstructured":"Burnett MS, Lee CW, Kinnaird TD, Stabile E, Durrani S, Dullum MK, Devaney JM, Fishman C, Stamou S, Canos D, Zbinden S, Clavijo LC, Jang GJ, Andrews JA, Zhu J, Epstein SE (2005) The potential role of resistin in atherogenesis. Atherosclerosis 182:241\u2013248","journal-title":"Atherosclerosis"},{"key":"755_CR15","first-page":"295","volume":"70","author":"S Cacanyiova","year":"2019","unstructured":"Cacanyiova S, Majzunova M, Golas S, Berenyiova A (2019) The role of perivascular adipose tissue and endogenous hydrogen sulfide in vasoactive responses of isolated mesenteric arteries in normotensive and spontaneously hypertensive rats. J Physiol Pharmacol 70:295\u2013306","journal-title":"J Physiol Pharmacol"},{"key":"755_CR16","doi-asserted-by":"publisher","first-page":"2886","DOI":"10.3390\/molecules25122886","volume":"25","author":"S Cacanyiova","year":"2020","unstructured":"Cacanyiova S, Krskova K, Zorad S, Frimmel K, Drobna M, Valaskova Z, Misak A, Golas S, Breza J, Breza J Jr, Berenyiova A (2020) Arterial hypertension and plasma glucose modulate the vasoactive effects of nitroso-sulfide coupled signaling in human intrarenal arteries. Molecules 25:2886","journal-title":"Molecules"},{"key":"755_CR17","doi-asserted-by":"publisher","first-page":"2949","DOI":"10.2337\/db10-0582","volume":"59","author":"J Chang","year":"2010","unstructured":"Chang J, Li Y, Huang Y, Lam KS, Hoo RL, Wong WT, Cheng KK, Wang Y, Vanhoutte PM, Xu A (2010) Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase\/p16INK4A signaling pathway. Diabetes 59:2949\u20132959","journal-title":"Diabetes"},{"key":"755_CR18","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.1161\/ATVBAHA.120.312464","volume":"40","author":"L Chang","year":"2020","unstructured":"Chang L, Garcia-Barrio MT, Chen YE (2020) Perivascular adipose tissue regulates vascular function by targeting vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 40:1094\u20131109","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"755_CR19","doi-asserted-by":"publisher","first-page":"H193","DOI":"10.1152\/ajpheart.00431.2009","volume":"299","author":"C Chen","year":"2010","unstructured":"Chen C, Jiang J, L\u00fc J-M, Chai H, Wang X, Lin PH, Yao Q (2010) Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol 299:H193\u2013H201","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"755_CR20","doi-asserted-by":"publisher","first-page":"1387","DOI":"10.2337\/db06-1580","volume":"56","author":"KK Cheng","year":"2007","unstructured":"Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A (2007) Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabete 56:1387\u20131394","journal-title":"Diabete"},{"key":"755_CR21","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1253\/circj.72.1249","volume":"72","author":"S Chu","year":"2008","unstructured":"Chu S, Ding W, Li K, Pang Y, Tang C (2008) Plasma resistin associated with myocardium injury in patients with acute coronary syndrome. Circ J 72:1249\u20131253","journal-title":"Circ J"},{"key":"755_CR22","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.vph.2017.05.004","volume":"93-95","author":"J Donovan","year":"2017","unstructured":"Donovan J, Wong PS, Roberts R, Garle MJ, Alexander SPH, Dunn WR, Ralevic V (2017) A critical role for cystathionine-\u03b2-synthase in hydrogen sulfide-mediated hypoxic relaxation of the coronary artery. Vascular Pharmacol 93-95:20\u201332","journal-title":"Vascular Pharmacol"},{"key":"755_CR23","doi-asserted-by":"publisher","first-page":"13126","DOI":"10.1111\/apha.13126","volume":"224","author":"J Donovan","year":"2018","unstructured":"Donovan J, Wong PS, Garle MJ, Alexander SPH, Dunn WR, Ralevic V (2018) Coronary artery hypoxic vasorelaxation is augmented by perivascular adipose tissue through a mechanism involving hydrogen sulphide and cystathionine-\u03b2-synthase. Acta Physiol 224:13126","journal-title":"Acta Physiol"},{"key":"755_CR24","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1080\/13102818.2014.991565","volume":"29","author":"R Emilova","year":"2015","unstructured":"Emilova R, Dimitrova D, Mladenov M, Daneva T, Schubert R, Gagov H (2015) Cystathionine gamma-lyase of perivascular adipose tissue with reversed regulatory effect in diabetic rat artery. Biotechnol Biotechnol Equip 29:147\u2013151","journal-title":"Biotechnol Biotechnol Equip"},{"key":"755_CR25","doi-asserted-by":"publisher","first-page":"2174","DOI":"10.1097\/HJH.0b013e328330a900","volume":"27","author":"L Fang","year":"2009","unstructured":"Fang L, Zhao J, Chen Y, Ma T, Xu G, Tang C, Liu X, Geng B (2009) Hydrogen sulfide derived from periadventitial adipose tissue is a vasodilator. J Hypertens 27:2174\u20132185","journal-title":"J Hypertens"},{"key":"755_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.clim.2009.07.013","volume":"133","author":"M Filkov\u00e1","year":"2009","unstructured":"Filkov\u00e1 M, Haluz\u00edk M, Gay S, Senolt L (2009) The role of resistin as a regulator of inflammation: Implications for various human pathologies. Clin Immunol 133:157\u2013170","journal-title":"Clin Immunol"},{"key":"755_CR27","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1161\/01.ATV.0000220381.40739.dd","volume":"26","author":"B Galvez","year":"2006","unstructured":"Galvez B, de Castro J, Herold D, Dubrovska G, Arribas S, Gonz\u00e0lez MC, Aranguez I, Luft FC, Ramos MP, Gollasch M, Alfonso MSF (2006) Perivascular adipose tissue and mesenteric vascular function in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol 26:1297\u20131302","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"755_CR28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1677\/JOE-07-0284","volume":"197","author":"B Galvez-Prieto","year":"2008","unstructured":"Galvez-Prieto B, Bolbrinker J, Stucchi P, de Las Heras AI, Merino B, Arribas S, Ruiz-Gayo M, Huber M, Wehland M, Kreutz M, Fernandez-Alfonso MS (2008) Comparative expression analysis of the renin-angiotensin system components between white and brown perivascular adipose tissue. J Endocrinol 197:55\u201364","journal-title":"J Endocrinol"},{"key":"755_CR29","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/sj.bjp.0707228","volume":"151","author":"YJ Gao","year":"2007","unstructured":"Gao YJ, Lu C, Su LY, Sharma AM, Lee RM (2007) Modulation of vascular function by perivascular adipose tissue: the role of endothelium and hydrogen peroxide. Br J Pharmacol 151:323\u2013331","journal-title":"Br J Pharmacol"},{"key":"755_CR30","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.tem.2015.04.003","volume":"26","author":"M Gil-Ortega","year":"2015","unstructured":"Gil-Ortega M, Somoza B, Huang Y, Gollasch M, Fernandez-Alfonso MS (2015) Regional differences in perivascular adipose tissue impacting vascular homeostasis. Trends Endocrinol Metab 26:367\u2013375","journal-title":"Trends Endocrinol Metab"},{"issue":"12","key":"755_CR31","doi-asserted-by":"publisher","first-page":"457","DOI":"10.3390\/biom12030457","volume":"16","author":"S Golas","year":"2022","unstructured":"Golas S, Berenyiova A, Majzunova M, Drobna M, Tuorkey MJ, Cacanyiova S (2022) The vasoactive effect of perivascular adipose tissue and hydrogen sulfide in thoracic aortas of normotensive and spontaneously hypertensive rats. Biomolecules 16(12):457","journal-title":"Biomolecules"},{"key":"755_CR32","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1111\/j.1476-5381.2011.01430.x","volume":"165","author":"M Gollasch","year":"2012","unstructured":"Gollasch M (2012) Vasodilator signals from perivascular adipose tissue. Br J Pharmacol 165:633\u2013642","journal-title":"Br J Pharmacol"},{"key":"755_CR33","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1161\/CIRCULATIONAHA.108.821181","volume":"119","author":"AS Greenstein","year":"2009","unstructured":"Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, Pemberton PW, Malik RA et al (2009) Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 119:1661\u20131670","journal-title":"Circulation"},{"key":"755_CR34","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/878052","volume":"2012","author":"W Guo","year":"2012","unstructured":"Guo W, Kan JT, Cheng ZY, Chen JF, Shen YQ, Xu J, Wu D, Zhu YZ (2012) Hydrogen sulfide as an endogenous modulator in mitochondria and mitochondria dysfunction. Oxidative Med Cell Longev 2012:878052","journal-title":"Oxidative Med Cell Longev"},{"key":"755_CR35","first-page":"505","volume":"54","author":"T Guzik","year":"2007","unstructured":"Guzik T, Mangalat D, Korbut R (2007) Adipocytokines\u2014novel link between inflammation and vascular function? J Physiol Pharmacol 54:505\u2013528","journal-title":"J Physiol Pharmacol"},{"key":"755_CR36","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41580-023-00680-1","volume":"25","author":"CE Hagberg","year":"2024","unstructured":"Hagberg CE, Spalding KL (2024) White adipocyte dysfunction and obesity-associated pathologies in humans. Nat Rev Mol Cell Biol 25:270\u2013289. Erratum in: Nat Rev Mol Cell Biol. 2024;25:333","journal-title":"Nat Rev Mol Cell Biol"},{"key":"755_CR37","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1038\/nm.3361","volume":"19","author":"M Harms","year":"2013","unstructured":"Harms M, Seale P (2013) Brown and beige fat: development, function and therapeutic potential. Nat Med 19:1252\u20131263","journal-title":"Nat Med"},{"key":"755_CR38","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1124\/jpet.115.227017","volume":"356","author":"ER Hedegaard","year":"2016","unstructured":"Hedegaard ER, Gouliaev A, Winther AK, Arcanjo DD, Aalling M, Renaltan NS, Wood ME, Whiteman M, Skovgaard N, Simonsen U (2016) Involvement of potassium channels and calcium-independent mechanisms in hydrogen sulfide-induced relaxation of rat mesenteric small arteries. J Pharmacol Exp Ther 356:53\u201363","journal-title":"J Pharmacol Exp Ther"},{"key":"755_CR39","doi-asserted-by":"publisher","first-page":"R97","DOI":"10.1530\/JOE-18-0598","volume":"241","author":"CT Herz","year":"2019","unstructured":"Herz CT, Kiefer FW (2019) Adipose tissue browning in mice and humans. J Endocrinol 241:R97\u2013R109","journal-title":"J Endocrinol"},{"key":"755_CR40","doi-asserted-by":"publisher","first-page":"1595","DOI":"10.1161\/01.ATV.20.6.1595","volume":"20","author":"K Hotta","year":"2000","unstructured":"Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y, Iwahashi H, Kuriyama H, Ouchi N, Maeda K, Nishida M, Kihara S, Sakai N, Nakajima T, Hasegawa K, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Hanafusa T, Matsuzawa Y (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol 20:1595\u20131599","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"755_CR41","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3109\/10641960902993129","volume":"32","author":"F Huang","year":"2010","unstructured":"Huang F, Lezama MAR, Ontiveros JAP, Bravo G, Villafana S, Estela del-Rio-Navarro B, Hong E (2010) Effect of losartan on vascular function in fructose-fed rats: the role of perivascular adipose tissue. Clin Exp Hypertens 32:98\u2013104","journal-title":"Clin Exp Hypertens"},{"key":"755_CR42","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.3390\/antiox12081644","volume":"12","author":"D Huang","year":"2023","unstructured":"Huang D, Jing G, Zhu S (2023) Regulation of mitochondrial respiration by hydrogen sulfide. Antioxidants (Basel). 12:1644","journal-title":"Antioxidants (Basel)."},{"key":"755_CR43","doi-asserted-by":"publisher","first-page":"32794","DOI":"10.1371\/journal.pone.0032794","volume":"7","author":"M Hulsmans","year":"2012","unstructured":"Hulsmans M, Van Dooren E, Mathieu C, Holvoet P (2012) Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin. PLoS One 7:32794","journal-title":"PLoS One"},{"key":"755_CR44","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1152\/ajpheart.00053.2013","volume":"305","author":"H Kawahito","year":"2013","unstructured":"Kawahito H, Yamada H, Irie D, Kato T, Akakabe Y, Kishida S, Takata H, Wakana N, Ogata T, Ikeda K, Ueyama T, Matoba S, Mori Y, Matsubara H (2013) Periaortic adipose tissue-specific activation of the renin-angiotensin system contributes to atherosclerosis development in uninephrectomized apoE\u2212\/\u2212 mice. Am J Physiol Heart Circ Physiol 305:667\u2013675","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"755_CR45","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1016\/j.bbrc.2003.12.104","volume":"314","author":"D Kawanami","year":"2004","unstructured":"Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, Manabe I, Utsunomiya K, Nagai R (2004) Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun 314:415\u2013419","journal-title":"Biochem Biophys Res Commun"},{"key":"755_CR46","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1292\/jvms.12-0537","volume":"75","author":"K Kazama","year":"2013","unstructured":"Kazama K, Okada M, Hara Y, Yamawaki H (2013) A novel adipocytokine, omentin, inhibits agonists-induced increases of blood pressure in rats. J Vet Med Sci 75:1029\u20131034","journal-title":"J Vet Med Sci"},{"key":"755_CR47","doi-asserted-by":"publisher","first-page":"H1714","DOI":"10.1152\/ajpheart.00048.2014","volume":"306","author":"K Kazama","year":"2014","unstructured":"Kazama K, Okada M, Yamawaki H (2014a) A novel adipocytokine, omentin, inhibits platelet-derived growth factor-BB-induced vascular smooth muscle cell migration through antioxidative mechanism. Am J Physiol Heart Circ Physiol 306:H1714","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"755_CR48","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.bbrc.2014.08.070","volume":"452","author":"K Kazama","year":"2014","unstructured":"Kazama K, Okada M, Yamawaki H (2014b) A novel adipocytokine, omentin, inhibits monocrotaline-induced pulmonary arterial hypertension in rats. Biochem Biophys Res Commun 452:142\u2013146","journal-title":"Biochem Biophys Res Commun"},{"key":"755_CR49","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1253\/circj.CJ-09-0661","volume":"74","author":"J Ketonen","year":"2010","unstructured":"Ketonen J, Shi J, Martonen E, Mervaala E (2010) Periadventitial adipose tissue promotes endothelial dysfunction via oxidative stress in diet-induced obese C57Bl\/6 mice. Circ J 74:1479\u20131487","journal-title":"Circ J"},{"key":"755_CR50","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/S0031-6997(24)01434-0","volume":"52","author":"S Kim","year":"2000","unstructured":"Kim S, Iwao H (2000) Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 52:11\u201334","journal-title":"Pharmacol Rev"},{"key":"755_CR51","doi-asserted-by":"publisher","first-page":"2569","DOI":"10.1161\/ATVBAHA.120.312470","volume":"40","author":"HW Kim","year":"2020","unstructured":"Kim HW, Shi H, Winkler MA, Lee R, Weintraub NL (2020) Perivascular adipose tissue and vascular perturbation\/atherosclerosis. Arterioscler Thromb Vasc Biol 40:2569\u20132576","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"755_CR52","doi-asserted-by":"publisher","first-page":"41951","DOI":"10.1371\/journal.pone.0041951","volume":"7","author":"C Kohn","year":"2012","unstructured":"Kohn C, Schleifenbaum J, Szijarto IA, Marko L, Dubrovska G, Huang Y, Gollasch M (2012) Differential effects of cystathionine-gamma-lyase dependent vasodilatory H2S in periadventitial vasoregulation of rat and mouse aortas. PLoS One 7:41951","journal-title":"PLoS One"},{"key":"755_CR53","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1097\/HJH.0b013e328324ed86","volume":"27","author":"RM Lee","year":"2009","unstructured":"Lee RM, Lu C, Su LY, Gao YJ (2009) Endothelium-dependent relaxation factor released by perivascular adipose tissue. J Hypertens 27:782\u2013790","journal-title":"J Hypertens"},{"key":"755_CR54","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1161\/CIRCULATIONAHA.111.027375","volume":"124","author":"YC Lee","year":"2011","unstructured":"Lee YC, Chang HH, Chiang CL, Liu CH, Yeh JI, Chen MF, Chen PY, Kuo JS, Lee TJ (2011) Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. Circulation 124:1160\u20131171","journal-title":"Circulation"},{"key":"755_CR55","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.plefa.2018.11.011","volume":"147","author":"RH Lee","year":"2019","unstructured":"Lee RH, Couto E Silva A, Possoit HE, Lerner FM, Chen PY, Azizbayeva R, Citadin CT, Wu CY, Neumann JT, Lin HW (2019) Palmitic acid methyl ester is a novel neuroprotective agent against cardiac arrest. Prostaglandins Leukot Essent Fatty Acids 147:6\u201314","journal-title":"Prostaglandins Leukot Essent Fatty Acids"},{"key":"755_CR57","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.ejphar.2012.09.026","volume":"698","author":"R Li","year":"2013","unstructured":"Li R, Andersen I, Aleke J, Golubinskaya V, Gustafsson H, Nilsson H (2013) Reduced anti-contractile effect of perivascular adipose tissue on mesenteric small arteries from spontaneously hypertensive rats: role of Kv7 channels. Eur J Pharmacol 698:310\u2013315","journal-title":"Eur J Pharmacol"},{"key":"755_CR58","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1177\/1535370214527903","volume":"239","author":"H Li","year":"2014","unstructured":"Li H, Wang YP, Zhang LN, Tian G (2014) Perivascular adipose tissue-derived leptin promotes vascular smooth muscle cell phenotypic switching via p38 mitogen-activated protein kinase in metabolic syndrome rats. Exp Biol Med (Maywood) 239:954\u2013965","journal-title":"Exp Biol Med (Maywood)"},{"key":"755_CR59","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.697720","volume":"12","author":"X Li","year":"2021","unstructured":"Li X, Ma Z, Zhu YZ (2021) Regional heterogeneity of perivascular adipose tissue: morphology, origin, and secretome. Front Pharmacol 12:697720","journal-title":"Front Pharmacol"},{"key":"755_CR60","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.diabres.2011.03.001","volume":"93","author":"R Liu","year":"2011","unstructured":"Liu R, Wang X, Bu P (2011) Omentin-1 is associated with carotid atherosclerosis in patients with metabolic syndrome. Diabetes Res Clin Pract 93:21\u201325","journal-title":"Diabetes Res Clin Pract"},{"key":"755_CR61","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1124\/jpet.119.263517","volume":"373","author":"CH Liu","year":"2020","unstructured":"Liu CH, Hsu HJ, Tseng TL, Lin T, Weng WH, Chen MF, Lee TJF (2020) COMT-catalyzed palmitic acid methyl ester biosynthesis in perivascular adipose tissue and its potential role against hypertension. J Pharmacol Exp Ther 373:175\u2013183","journal-title":"J Pharmacol Exp Ther"},{"key":"755_CR62","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1096\/fj.02-0024com","volume":"16","author":"M L\u00f6hn","year":"2002","unstructured":"L\u00f6hn M, Dubrovska G, Lauterbach B, Luft FC, Gollasch M, Sharma AM (2002) Periadventitial fat releases a vascular relaxing factor. FASEB J 16:1057\u20131063","journal-title":"FASEB J"},{"key":"755_CR63","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ejphar.2010.02.006","volume":"634","author":"C Lu","year":"2010","unstructured":"Lu C, Su L-Y, Lee RMKW, Gao Y-J (2010) Mechanisms for perivascular adipose tissue-mediated potentiation of vascular contraction to perivascular neuronal stimulation: the role of adipocyte-derived angiotensin II. Eur J Pharmacol 634:107\u2013112","journal-title":"Eur J Pharmacol"},{"key":"755_CR64","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ejphar.2011.01.023","volume":"656","author":"C Lu","year":"2011","unstructured":"Lu C, Su LY, Lee RM, Gao YJ (2011) Alterations in perivascular adipose tissue structure and function in hypertension. Eur J Pharmacol 656:68\u201373","journal-title":"Eur J Pharmacol"},{"key":"755_CR65","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.3389\/fphar.2018.01226","volume":"26(9)","author":"J Luo","year":"2018","unstructured":"Luo J, Huang L, Wang A, Liu Y, Cai R, Li W, Zhou MS (2018) Resistin-induced endoplasmic reticulum stress contributes to the impairment of insulin signaling in endothelium. Front Pharmacol 26(9):1226. Erratum in: Front Pharmacol. 2018; 9:1446","journal-title":"Front Pharmacol"},{"key":"755_CR66","doi-asserted-by":"publisher","first-page":"786","DOI":"10.1152\/ajpheart.00697.2012","volume":"304","author":"FM Lynch","year":"2013","unstructured":"Lynch FM, Withers SB, Yao Z, Werner ME, Edwards G, Weston AH, Heagerty AM (2013) Perivascular adipose tissue-derived adiponectin activates BK(Ca) channels to induce anticontractile responses. Am J Physiol Heart Circ Physiol 304:786\u2013795","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"755_CR67","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/hr.2010.11","volume":"33","author":"L Ma","year":"2010","unstructured":"Ma L, Ma S, He H, Yang D, Chen X, Luo Z, Liu D, Zhu Z (2010) Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK\/mTOR pathway in high-fat diet-induced obese rats. Hypertens Res 33:446\u2013453","journal-title":"Hypertens Res"},{"key":"755_CR68","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ejcts.2007.11.007","volume":"33","author":"M Malinowski","year":"2008","unstructured":"Malinowski M, Deja MA, Golba KS, Roleder T, Biernat J, Wos S (2008) Perivascular tissue of internal thoracic artery releases potent nitric oxide and prostacyclin-independent anticontractile factor. Eur J Cardiothorac Surg 33:225\u2013231","journal-title":"Eur J Cardiothorac Surg"},{"key":"755_CR69","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1161\/CIRCULATIONAHA.112.001133","volume":"127","author":"M Margaritis","year":"2013","unstructured":"Margaritis M, Antonopoulos AS, Digby J, Lee R, Reilly S, Coutinho P, Shirodaria C, Sayeed R, Petrou M, De Silva R, Jalilzadeh S, Demosthenous M, Bakogiannis C, Tousoulis D, Stefanadis C, Choudhury RP, Casadei B, Channon KM, Antoniades C (2013) Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation 127:2209\u20132221","journal-title":"Circulation"},{"key":"755_CR70","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/j.1476-5381.2011.01404.x","volume":"165","author":"CY Miao","year":"2012","unstructured":"Miao CY, Li ZY (2012) The role of perivascular adipose tissue in vascular smooth muscle cell growth. Br J Pharmacol 165:43\u2013658","journal-title":"Br J Pharmacol"},{"key":"755_CR71","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1089\/ars.2021.0147","volume":"37","author":"E Mitidieri","year":"2022","unstructured":"Mitidieri E et al (2022) The role of perivascular adipose tissue-derived hydrogen sulfide in the control of vascular homeostasis. Antioxid Redox Signal 37:84\u201397","journal-title":"Antioxid Redox Signal"},{"key":"755_CR72","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.cardiores.2006.01.015","volume":"70","author":"H Mu","year":"2006","unstructured":"Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C (2006) Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res 70:146\u2013157","journal-title":"Cardiovasc Res"},{"key":"755_CR73","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.niox.2018.12.011","volume":"84","author":"N N\u00f3brega","year":"2019","unstructured":"N\u00f3brega N, Ara\u00fajo NF, Reis D, Facine LM, Miranda CAS, Mota GC, Aires RD, Capettini LDSA, Cruz JDS, Bonaventura D (2019) Hydrogen peroxide and nitric oxide induce anticontractile effect of perivascular adipose tissue via renin angiotensin system activation. Nitric Oxide 84:50\u201359","journal-title":"Nitric Oxide"},{"key":"755_CR74","doi-asserted-by":"publisher","first-page":"3496","DOI":"10.1111\/bph.13705","volume":"174","author":"R Nosalski","year":"2017","unstructured":"Nosalski R, Guzik TJ (2017) Perivascular adipose tissue inflammation in vascular disease. Br J Pharmacol 174:3496\u20133513","journal-title":"Br J Pharmacol"},{"issue":"12","key":"755_CR75","doi-asserted-by":"publisher","first-page":"1919","DOI":"10.3390\/antiox12111919","volume":"26","author":"PB Oliveira","year":"2023","unstructured":"Oliveira PB, Zochio GP, Caetano ESP, da Silva MLS, Dias-Junior CA (2023) Vasodilator responses of perivascular adipose tissue-derived hydrogen sulfide stimulated with L-cysteine in pregnancy hypertension-induced endothelial dysfunction in rats. Antioxidants (Basel) 26(12):1919","journal-title":"Antioxidants (Basel)"},{"key":"755_CR76","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1161\/CIRCULATIONAHA.112.001238","volume":"128","author":"MK Owen","year":"2013","unstructured":"Owen MK, Witzmann FA, McKenney ML, Lai X, Berwick ZC, Moberly SP, Alloosh M, Sturek M, Tune JD (2013) Perivascular adipose tissue potentiates contraction of coronary vascular smooth muscle: Influence of obesity. Circulation 128:9\u201318","journal-title":"Circulation"},{"key":"755_CR77","first-page":"10.1002","volume":"33","author":"PA Peri-Okonny","year":"2016","unstructured":"Peri-Okonny PA, Ayers C, Maalouf N, Das SR, de Lemos JA, Berry JD, Turer AT, Neeland IJ, Scherer PE, Vongpatanasin W (2016) Adiponectin protects against incident hypertension independent of body fat distribution: observations from the Dallas Heart Study. Diabetes Metab Res Rev 33:10.1002","journal-title":"Diabetes Metab Res Rev"},{"key":"755_CR78","doi-asserted-by":"publisher","first-page":"3482","DOI":"10.1111\/bph.13767","volume":"174","author":"JG Ramirez","year":"2017","unstructured":"Ramirez JG, O\u2019Malley EJ, Ho WSV (2017) Pro-contractile effects of perivascular fat in health and disease. Br J Pharmacol 174:3482\u20133495","journal-title":"Br J Pharmacol"},{"key":"755_CR79","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1161\/01.CIR.0000155620.10387.43","volume":"111","author":"MP Reilly","year":"2005","unstructured":"Reilly MP, Lehrke M, Wolfe ML, Rohatgi A, Lazar MA, Rader DJ (2005) Resistin is an inflammatory marker of atherosclerosis in humans. Circulation 111:932\u2013939","journal-title":"Circulation"},{"key":"755_CR80","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1089\/acm.2012.0086","volume":"19","author":"K Sarvottam","year":"2013","unstructured":"Sarvottam K, Magan D, Yadav RK, Mehta N, Mahapatra SC (2013) Adiponectin, interleukin-6, and cardiovascular disease risk factors are modified by a short-term yoga-based lifestyle intervention in overweight and obese men. J Altern Complement Med 19:397\u2013402","journal-title":"J Altern Complement Med"},{"key":"755_CR81","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1097\/HJH.0b013e32833c20d5","volume":"28","author":"J Schleifenbaum","year":"2010","unstructured":"Schleifenbaum J, K\u00f6hn C, Voblova N, Dubrovska G, Zavarirskaya O, Gloe T, Crean CS, Luft FC, Huang Y, Schubert R, Gollasch M (2010) Systemic peripheral artery relaxation by KCNQ channel openers and hydrogen sulfide. J Hypertens 28:1875\u20131882","journal-title":"J Hypertens"},{"key":"755_CR82","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.atherosclerosis.2011.08.017","volume":"219","author":"R Shibata","year":"2011","unstructured":"Shibata R, Ouchi N, Kikuchi R, Takahashi R, Takeshita K, Kataoka Y, Ohashi K, Ikeda N, Kihara S, Murohara T (2011) Circulating omentin is associated with coronary artery disease in men. Atherosclerosis 219:811\u2013814","journal-title":"Atherosclerosis"},{"key":"755_CR83","doi-asserted-by":"publisher","first-page":"E1253","DOI":"10.1152\/ajpendo.00572.2004","volume":"290","author":"AR Shuldiner","year":"2006","unstructured":"Shuldiner AR, Fried SK, McLenithan JC, Gong DW (2006) Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action. Am J Physiol Endocrinol Metab 290:E1253\u2013E1261","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"755_CR84","doi-asserted-by":"publisher","first-page":"6897","DOI":"10.1038\/s41598-019-43326-z","volume":"9","author":"HY Small","year":"2019","unstructured":"Small HY, McNeilly S, Mary S, Sheikh AM, Delles C (2019) Resistin mediates sex-dependent effects of perivascular adipose tissue on vascular function in the shrsp. Sci Rep 9:6897","journal-title":"Sci Rep"},{"key":"755_CR85","first-page":"277","volume":"13","author":"EE Soltis","year":"1991","unstructured":"Soltis EE, Cassis LA (1991) Influence of perivascular adipose tissue on rat aortic smooth muscle responsiveness. Clin Exp Hypertens A 13:277\u2013296","journal-title":"Clin Exp Hypertens A"},{"key":"755_CR86","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI129167","volume":"130","author":"A Song","year":"2020","unstructured":"Song A, Dai W, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA (2020) Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. J Clin Invest 130:247\u2013257","journal-title":"J Clin Invest"},{"key":"755_CR87","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1111\/1440-1681.13550","volume":"48","author":"AS Sousa","year":"2021","unstructured":"Sousa AS, Sponton ACS, Delbin MA (2021) Perivascular adipose tissue and microvascular endothelial dysfunction in obese mice: Beneficial effects of aerobic exercise in adiponectin receptor (AdipoR1) and peNOS(Ser1177). Clin Exp Pharmacol Physiol 48:1430\u20131440","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"755_CR88","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1097\/FJC.0000000000000917","volume":"76","author":"E Souza-Paula","year":"2020","unstructured":"Souza-Paula E, Polonio LCC, Zochio GP, Pinho da Silva K, Kushima H, Dias-Junior CA (2020) Anticontractile effect of perivascular adipose tissue but not of endothelium is enhanced by hydrogen sulfide stimulation in hypertensive pregnant rat aortae. J Cardiovasc Pharmacol 76:715\u2013729","journal-title":"J Cardiovasc Pharmacol"},{"key":"755_CR89","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1038\/35053000","volume":"409","author":"CM Steppan","year":"2001","unstructured":"Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature 409:307\u2013312","journal-title":"Nature"},{"key":"755_CR90","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1016\/j.cmet.2016.04.011","volume":"23","author":"JH Stern","year":"2016","unstructured":"Stern JH, Rutkowski JM, Scherer PE (2016) Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab 23:770\u2013784","journal-title":"Cell Metab"},{"key":"755_CR91","doi-asserted-by":"publisher","first-page":"2099","DOI":"10.1111\/bph.12369","volume":"171","author":"C Szabo","year":"2014","unstructured":"Szabo C, Ransy C, M\u00f3dis K, Andriamihaja M, Murghes B, Coletta C, Olah G, Yanagi K, Bouillaud F (2014) Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms. Br J Pharmacol 171:2099\u20132122","journal-title":"Br J Pharmacol"},{"key":"755_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/CS20110151","volume":"122","author":"T Szasz","year":"2012","unstructured":"Szasz T, Webb RC (2012) Perivascular adipose tissue: more than just structural support. Clin Sci (Lond) 122:1\u201312","journal-title":"Clin Sci (Lond)"},{"key":"755_CR93","doi-asserted-by":"publisher","first-page":"105","DOI":"10.2147\/VHRM.S33760","volume":"9","author":"T Szasz","year":"2013","unstructured":"Szasz T, Bomfim GF, Webb RC (2013) The influence of perivascular adipose tissue on vascular homeostasis. Vasc Health Risk Manag 9:105\u2013116","journal-title":"Vasc Health Risk Manag"},{"key":"755_CR94","doi-asserted-by":"publisher","first-page":"79","DOI":"10.4103\/2277-9175.156526","volume":"4","author":"Z Tahergorabi","year":"2015","unstructured":"Tahergorabi Z, Khazaei M (2015) Leptin and its cardiovascular effects: focus on angiogenesis. Adv Biomed Res 4:79","journal-title":"Adv Biomed Res"},{"key":"755_CR95","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.1161\/ATVBAHA.114.303032","volume":"34","author":"JY Tano","year":"2014","unstructured":"Tano JY, Schleifenbaum J, Gollasch M (2014) Perivascular adipose tissue, potassium channels, and vascular dysfunction. Arterioscler Thromb Vasc Biol 34:1827\u20131830","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"755_CR96","doi-asserted-by":"publisher","first-page":"2826","DOI":"10.2337\/db09-1881","volume":"59","author":"L Tedesco","year":"2010","unstructured":"Tedesco L, Valerio A, Dossena M, Cardile A, Ragni M, Pagano C, Pagotto U, Carruba MO, Vettor R, Nisoli E (2010) Cannabinoid receptor stimulation impairs mitochondrial biogenesis in mouse white adipose tissue, muscle, and liver: the role of eNOS, p38 MAPK, and AMPK pathways. Diabetes 59:2826\u20132836","journal-title":"Diabetes"},{"key":"755_CR97","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115728","volume":"215","author":"L Testai","year":"2023","unstructured":"Testai L, Montanaro R, Flori L, Pagnotta E, Vellecco V, Gorica E, Ugolini L, Righetti L, Brancaleone V, Bucci M, Piragine E, Martelli A, Di Cesare Mannelli L, Ghelardini C, Calderone V (2023) Persulfidation of mitoKv7.4 channels contributes to the cardioprotective effects of the H2S-donor Erucin against ischemia\/reperfusion injury. Biochem Pharmacol 215:115728","journal-title":"Biochem Pharmacol"},{"key":"755_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1152\/physrev.00017.2012","volume":"93","author":"P Trayhurn","year":"2013","unstructured":"Trayhurn P (2013) Hypoxia and adipose tissue function and dysfunction in obesity. Physiol Rev 93:1\u201321","journal-title":"Physiol Rev"},{"key":"755_CR99","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1096\/fj.14-258129","volume":"29","author":"Y Uemura","year":"2015","unstructured":"Uemura Y, Shibata R, Kanemura N, Ohashi K, Kambara T, Hiramatsu-Ito M, Enomoto T, Yuasa D, Joki Y, Matsuo K, Ito M, Hayakawa S, Ogawa H, Murohara T, Ouchi N (2015) Adipose-derived protein omentin prevents neointimal formation after arterial injury. FASEB J 29:141\u2013151","journal-title":"FASEB J"},{"key":"755_CR100","doi-asserted-by":"publisher","first-page":"403","DOI":"10.2174\/1570161112666140423220628","volume":"12","author":"J Van de Voorde","year":"2014","unstructured":"Van de Voorde J, Boydens C, Pauwels B, Decaluwe K (2014) Perivascular adipose tissue, inflammation and vascular dysfunction in obesity. Curr Vasc Pharmacol 12:403\u2013411","journal-title":"Curr Vasc Pharmacol"},{"key":"755_CR101","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1161\/01.HYP.0000140058.28994.ec","volume":"44","author":"S Verlohren","year":"2004","unstructured":"Verlohren S, Dubrovska G, Tsang SY, Essin K, Luft FC, Huang Y, Gollasch M (2004) Visceral periadventitial adipose tissue regulates arterial tone of mesenteric arteries. Hypertension 44:271\u2013276","journal-title":"Hypertension"},{"key":"755_CR102","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1093\/cvr\/cvn288","volume":"81","author":"P Wang","year":"2009","unstructured":"Wang P, Xu TY, Guan YF, Su DF, Fan GR, Miao CY (2009) Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor: role of nicotinamide mononucleotide. Cardiovasc Res 81:370\u2013380","journal-title":"Cardiovasc Res"},{"key":"755_CR103","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/bph.12157","volume":"169","author":"AH Weston","year":"2013","unstructured":"Weston AH, Egner I, Dong Y, Porter EL, Heagerty AM, Edwards G (2013) Stimulated release of a hyperpolarizing factor (ADHF) from mesenteric artery perivascular adipose tissue: involvement of myocyte BKCa channels and adiponectin. Br J Pharmacol 169:1500\u20131509","journal-title":"Br J Pharmacol"},{"key":"755_CR104","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1210\/jcem.86.5.7463","volume":"86","author":"C Weyer","year":"2001","unstructured":"Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930\u20131935","journal-title":"J Clin Endocrinol Metab"},{"key":"755_CR105","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1161\/ATVBAHA.114.303031","volume":"34","author":"SB Withers","year":"2014","unstructured":"Withers SB, Bussey CE, Saxton SN, Melrose HM, Watkins AE, Heagerty AM (2014) Mechanisms of adiponectin-associated perivascular function in vascular disease. Arterioscler Thromb Vasc Biol 34:1637\u20131642","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"755_CR106","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1093\/eurheartj\/ehl246","volume":"27","author":"R Wolk","year":"2006","unstructured":"Wolk R, Somers VK (2006) Leptin and vascular function: friend or foe? Eur Heart J 27:2263\u20132265","journal-title":"Eur Heart J"},{"key":"755_CR107","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1152\/ajpheart.00765.2011","volume":"302","author":"A Xu","year":"2012","unstructured":"Xu A, Vanhoutte PM (2012) Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. Am J Physiol Heart Circ Physiol 302:1231\u20131240","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"755_CR108","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.beem.2013.09.003","volume":"28","author":"T Yamauchi","year":"2014","unstructured":"Yamauchi T, Iwabu M, Okada-Iwabu M, Kadowaki T (2014) Adiponectin receptors: a review of their structure, function and how they work. Best Pract Res Clin Endocrinol Metab 28:15\u201323","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"755_CR109","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.bbrc.2010.02.053","volume":"393","author":"H Yamawaki","year":"2010","unstructured":"Yamawaki H, Tsubaki N, Mukohda M, Okada M, Hara Y (2010) Omentin, a novel adipokine, induces vasodilation in rat isolated blood vessels. Biochem Biophys Res Commun 393:668\u2013672","journal-title":"Biochem Biophys Res Commun"},{"key":"755_CR110","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.cyto.2006.05.005","volume":"34","author":"S Yaturu","year":"2006","unstructured":"Yaturu S, Daberry RP, Rains J, Jain S (2006) Resistin and adiponectin levels in subjects with coronary artery disease and type 2 diabetes. Cytokine 34:219\u2013223","journal-title":"Cytokine"},{"key":"755_CR111","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1055\/a-0867-1333","volume":"51","author":"PL Yu","year":"2019","unstructured":"Yu PL, Wang C, Li W, Zhang FX (2019) Visfatin level and the risk of hypertension and cerebrovascular accident: a systematic review and meta-analysis. Horm Metab Res 51:220\u2013229","journal-title":"Horm Metab Res"},{"key":"755_CR112","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1161\/HYPERTENSIONAHA.112.197566","volume":"61","author":"O Zavaritskaya","year":"2013","unstructured":"Zavaritskaya O, Zhuravleva N, Schleifenbaum J, Gloe T, Devermann L, Kluge R, Mladenov M, Frey M, Gagov H, F\u00e9sus G, Gallosch M, Schubert R (2013) Role of KCNQ channels in skeletal muscle arteries and periadventitial vascular dysfunction. Hypertension 61:151\u2013159","journal-title":"Hypertension"},{"key":"755_CR113","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1161\/ATVBAHA.108.178061","volume":"29","author":"P Zhang","year":"2009","unstructured":"Zhang P, Wang Y, Fan Y, Tang Z, Wang N (2009) Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arterioscler Thromb Vasc Biol 29:67\u201374","journal-title":"Arterioscler Thromb Vasc Biol"}],"container-title":["Handbook of Experimental Pharmacology","Hydrogen Sulfide: A Toxicant with Healing Potential"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2025_755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:02:15Z","timestamp":1777064535000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2025_755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783032244314","9783032244321"],"references-count":112,"URL":"https:\/\/doi.org\/10.1007\/164_2025_755","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"15 October 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}