{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T23:24:50Z","timestamp":1767309890732,"version":"3.48.0"},"publisher-location":"Cham","reference-count":288,"publisher":"Springer Nature Switzerland","isbn-type":[{"type":"print","value":"9783032132284"},{"type":"electronic","value":"9783032132291"}],"license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025]]},"DOI":"10.1007\/164_2025_773","type":"book-chapter","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:06:24Z","timestamp":1761739584000},"page":"277-318","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GPCR Biased Signaling in Cancer"],"prefix":"10.1007","author":[{"given":"Ariella C.","family":"Avigad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melody","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengyu","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Levin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosie J.","family":"Blodgett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera S.","family":"Donnenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert D.","family":"Donnenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick L.","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Bartlett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunhong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"773_CR1","doi-asserted-by":"publisher","first-page":"3717","DOI":"10.1002\/jcp.30847","volume":"237","author":"B Aamna","year":"2022","unstructured":"Aamna B, Dan AK, Sahu R, Behera SK, Parida S (2022) Deciphering the signaling mechanisms of \u03b2-arrestin1 and \u03b2-arrestin2 in regulation of cancer cell cycle and metastasis. J Cell Physiol 237:3717\u20133733","journal-title":"J Cell Physiol"},{"key":"773_CR2","doi-asserted-by":"publisher","unstructured":"Abballe L, Alfano V, Antonacci C, Cefalo MG, Cacchione A, Del Baldo G, Pezzullo M, Po A, Moretti M, Mastronuzzi A, De Smaele E, Ferretti E, Locatelli F, Miele E (2023) \u03b2-arrestin1-E2F1-ac axis regulates physiological apoptosis and cell cycle exit in cellular models of early postnatal cerebellum. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2023.990711","DOI":"10.3389\/fcell.2023.990711"},{"key":"773_CR3","doi-asserted-by":"publisher","first-page":"2258","DOI":"10.1111\/jth.14277","volume":"16","author":"GN Adams","year":"2018","unstructured":"Adams GN, Sharma BK, Rosenfeldt L, Frederick M, Flick MJ, Witte DP, Mosnier LO, Harmel-Laws E, Steinbrecher KA, Palumbo JS (2018) Protease-activated receptor-1 impedes prostate and intestinal tumor progression in mice. J Thromb Haemost 16:2258\u20132269","journal-title":"J Thromb Haemost"},{"key":"773_CR4","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1016\/j.cpt.2022.12.002","volume":"1","author":"H Ahmed","year":"2023","unstructured":"Ahmed H, Mahmud AR, Siddiquee MF, Shahriar A, Biswas P, Shimul MEK, Ahmed SZ, Ema TI, Rahman N, Khan MA, Mizan MFR, Emran TB (2023) Role of T cells in cancer immunotherapy: opportunities and challenges. Cancer Pathog Ther 1:116\u2013126","journal-title":"Cancer Pathog Ther"},{"key":"773_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2025.108849","volume":"270","author":"S Ahn","year":"2025","unstructured":"Ahn S, Kaipparettu BA (2025) G-protein coupled receptors in metabolic reprogramming and cancer. Pharmacol Ther 270:108849","journal-title":"Pharmacol Ther"},{"key":"773_CR6","doi-asserted-by":"publisher","first-page":"8855","DOI":"10.1074\/jbc.M808463200","volume":"284","author":"S Ahn","year":"2009","unstructured":"Ahn S, Kim J, Hara MR, Ren XR, Lefkowitz RJ (2009) Beta-Arrestin-2 mediates anti-apoptotic signaling through regulation of BAD phosphorylation. J Biol Chem 284:8855\u20138865","journal-title":"J Biol Chem"},{"key":"773_CR7","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.3390\/cells10061390","volume":"10","author":"S Aiello","year":"2021","unstructured":"Aiello S, Casiraghi F (2021) Lysophosphatidic acid: promoter of Cancer progression and of tumor microenvironment development. A promising target for anticancer therapies? Cells 10:1390","journal-title":"Cells"},{"key":"773_CR8","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ejphar.2014.02.007","volume":"729","author":"L Ajram","year":"2014","unstructured":"Ajram L, Begg M, Slack R, Cryan J, Hall D, Hodgson S, Ford A, Barnes A, Swieboda D, Mousnier A, Solari R (2014) Internalization of the chemokine receptor CCR4 can be evoked by orthosteric and allosteric receptor antagonists. Eur J Pharmacol 729:75\u201385","journal-title":"Eur J Pharmacol"},{"key":"773_CR9","first-page":"805","volume":"34","author":"M Alaa","year":"2009","unstructured":"Alaa M, Suzuki M, Yoshino M, Tian L, Suzuki H, Nagato K, Fujiwara T, Wada H, Moriya Y, Hoshino H, Motohashi S, Yoshida S, Shibuya K, Hiroshima K, Nakatani Y, Abdrabou A, Elkholy M, Mahfouz T, Yoshino I (2009) Prostaglandin E2 receptor 2 overexpression in squamous cell carcinoma of the lung correlates with p16INK4A methylation and an unfavorable prognosis. Int J Oncol 34:805\u2013812","journal-title":"Int J Oncol"},{"key":"773_CR10","doi-asserted-by":"publisher","first-page":"2187","DOI":"10.7314\/APJCP.2015.16.6.2187","volume":"16","author":"KM Alblazi","year":"2015","unstructured":"Alblazi KM, Siar CH (2015) Cellular protrusions\u2013lamellipodia, filopodia, invadopodia and podosomes\u2013and their roles in progression of orofacial tumours: current understanding. Asian Pac J Cancer Prev 16:2187\u20132191","journal-title":"Asian Pac J Cancer Prev"},{"key":"773_CR11","doi-asserted-by":"publisher","first-page":"4201","DOI":"10.1002\/1873-3468.14017","volume":"594","author":"N Arang","year":"2020","unstructured":"Arang N, Gutkind JS (2020) G protein-coupled receptors and heterotrimeric G proteins as cancer drivers. FEBS Lett 594:4201\u20134232","journal-title":"FEBS Lett"},{"key":"773_CR12","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1042\/CS20240426","volume":"138","author":"PF Arndt","year":"2024","unstructured":"Arndt PF, Turkowski K, Cekay MJ, Eul B, Grimminger F, Savai R (2024) Endothelin and the tumor microenvironment: a finger in every pie. Clin Sci (Lond) 138:617\u2013634","journal-title":"Clin Sci (Lond)"},{"key":"773_CR13","doi-asserted-by":"publisher","first-page":"13","DOI":"10.3390\/cancers13184720","volume":"13","author":"PJ Asif","year":"2021","unstructured":"Asif PJ, Longobardi C, Hahne M, Medema JP (2021) The role of Cancer-associated fibroblasts in Cancer invasion and metastasis. Cancers (Basel) 13:13","journal-title":"Cancers (Basel)"},{"key":"773_CR14","doi-asserted-by":"publisher","first-page":"114","DOI":"10.3389\/fphar.2019.00114","volume":"10","author":"A Bagnato","year":"2019","unstructured":"Bagnato A, Rosano L (2019) New routes in GPCR\/beta-Arrestin-driven signaling in Cancer progression and metastasis. Front Pharmacol 10:114","journal-title":"Front Pharmacol"},{"key":"773_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/S1043-2760(02)00010-3","volume":"14","author":"A Bagnato","year":"2003","unstructured":"Bagnato A, Spinella F (2003) Emerging role of endothelin-1 in tumor angiogenesis. Trends Endocrinol Metab 14:44\u201350","journal-title":"Trends Endocrinol Metab"},{"key":"773_CR16","doi-asserted-by":"crossref","unstructured":"Balijepalli P, Sitton CC, Meier KE (2021) Lysophosphatidic acid signaling in Cancer cells: what makes LPA so special? Cells 10","DOI":"10.3390\/cells10082059"},{"key":"773_CR17","doi-asserted-by":"publisher","first-page":"16287","DOI":"10.1074\/jbc.274.23.16287","volume":"274","author":"J Barlic","year":"1999","unstructured":"Barlic J, Khandaker MH, Mahon E, Andrews J, DeVries ME, Mitchell GB, Rahimpour R, Tan CM, Ferguson SS, Kelvin DJ (1999) Beta-arrestins regulate interleukin-8-induced CXCR1 internalization. J Biol Chem 274:16287\u201316294","journal-title":"J Biol Chem"},{"key":"773_CR18","doi-asserted-by":"publisher","unstructured":"Barnes WG, Reiter E, Violin JD, Ren XR, Milligan Lefkowitz RJ (2005) beta-Arrestin 1 and Galphaq\/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.M412924200","DOI":"10.1074\/jbc.M412924200"},{"key":"773_CR19","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.cell.2005.11.010","volume":"123","author":"JM Beaulieu","year":"2005","unstructured":"Beaulieu JM, Caron MG (2005) Beta-arrestin goes nuclear. Cell 123:755\u2013757","journal-title":"Cell"},{"key":"773_CR20","doi-asserted-by":"publisher","first-page":"141","DOI":"10.3389\/fendo.2013.00141","volume":"4","author":"A Belfiore","year":"2013","unstructured":"Belfiore A, Perks CM (2013) Grand challenges in cancer endocrinology: endocrine related cancers, an expanding concept. Front Endocrinol (Lausanne) 4:141","journal-title":"Front Endocrinol (Lausanne)"},{"key":"773_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12964-018-0233-2","volume":"16","author":"P Berning","year":"2018","unstructured":"Berning P, Schaefer C, Clemens D, Korsching E, Dirksen U, Potratz J (2018) The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling. Cell Commun Signal 16:21","journal-title":"Cell Commun Signal"},{"key":"773_CR22","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/ncb821","volume":"4","author":"M Bhattacharya","year":"2002","unstructured":"Bhattacharya M, Anborgh PH, Babwah AV, Dale LB, Dobransky T, Benovic JL, Feldman RD, Verdi JM, Rylett RJ, Ferguson SS (2002) Beta-arrestins regulate a Ral-GDS Ral effector pathway that mediates cytoskeletal reorganization. Nat Cell Biol 4:547\u2013555","journal-title":"Nat Cell Biol"},{"key":"773_CR23","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.3389\/fimmu.2020.02109","volume":"11","author":"ME Bianchi","year":"2020","unstructured":"Bianchi ME, Mezzapelle R (2020) The chemokine receptor CXCR4 in cell proliferation and tissue regeneration. Front Immunol 11:2109","journal-title":"Front Immunol"},{"key":"773_CR24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.coemr.2020.07.011","volume":"16","author":"CA Birch","year":"2021","unstructured":"Birch CA, Molinar-Inglis O, Trejo J (2021) Subcellular hot spots of GPCR signaling promote vascular inflammation. Curr Opin Endocr Metab Res 16:37\u201342","journal-title":"Curr Opin Endocr Metab Res"},{"key":"773_CR25","doi-asserted-by":"publisher","first-page":"6233","DOI":"10.1007\/s11033-023-08479-1","volume":"50","author":"M Bocchi","year":"2023","unstructured":"Bocchi M, de Sousa Pereira N, de Oliveira KB, Amarante MK (2023) Involvement of CXCL12\/CXCR4 axis in colorectal cancer: a mini-review. Mol Biol Rep 50:6233\u20136239","journal-title":"Mol Biol Rep"},{"key":"773_CR26","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1038\/s41598-021-80974-6","volume":"11","author":"SY Bostanabad","year":"2021","unstructured":"Bostanabad SY, Noyan S, Dedeoglu BG, Gurdal H (2021) Overexpression of beta-Arrestins inhibits proliferation and motility in triple negative breast cancer cells. Sci Rep 11:1539","journal-title":"Sci Rep"},{"key":"773_CR27","doi-asserted-by":"publisher","first-page":"1714","DOI":"10.1200\/JCO.2017.77.6385","volume":"36","author":"JR Brahmer","year":"2018","unstructured":"Brahmer JR, Lacchetti C, Schneider BJ, Atkins MB, Brassil KJ, Caterino JM, Chau I, Ernstoff MS, Gardner JM, Ginex P, Hallmeyer S, Holter Chakrabarty J, Leighl NB, Mammen JS, McDermott DF, Naing A, Nastoupil LJ, Phillips T, Porter LD, Puzanov I, Reichner CA, Santomasso BD, Seigel C, Spira A, Suarez-Almazor ME, Wang Y, Weber JS, Wolchok JD, Thompson JA, Network National Comprehensive Cancer (2018) Management of Immune-Related Adverse Events in patients treated with immune checkpoint inhibitor therapy: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol 36:1714\u20131768","journal-title":"J Clin Oncol"},{"key":"773_CR28","doi-asserted-by":"publisher","first-page":"1492","DOI":"10.1073\/pnas.0510562103","volume":"103","author":"FG Buchanan","year":"2006","unstructured":"Buchanan FG, Gorden DL, Matta P, Shi Q, Matrisian LM, DuBois RN (2006) Role of beta-arrestin 1 in the metastatic progression of colorectal cancer. Proc Natl Acad Sci USA 103:1492\u20131497","journal-title":"Proc Natl Acad Sci USA"},{"key":"773_CR29","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1182\/blood-2005-08-3182","volume":"107","author":"JA Burger","year":"2006","unstructured":"Burger JA, Kipps TJ (2006) CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107:1761\u20131767","journal-title":"Blood"},{"key":"773_CR30","doi-asserted-by":"publisher","first-page":"461","DOI":"10.21873\/cgp.20272","volume":"18","author":"C Cao","year":"2021","unstructured":"Cao C, Zhang Y, Cheng J, Wu F, Niu X, Hu X, Duan X, Fu X, Zhang J, Zhang X, Ao Y (2021) Beta-Arrestin2 inhibits the apoptosis and facilitates the proliferation of fibroblast-like Synoviocytes in diffuse-type Tenosynovial Giant cell tumor. Cancer Genomics Proteomics 18:461\u2013470","journal-title":"Cancer Genomics Proteomics"},{"key":"773_CR31","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/S0959-4388(98)80058-5","volume":"8","author":"CV Carman","year":"1998","unstructured":"Carman CV, Benovic JL (1998) G-protein-coupled receptors: turn-ons and turn-offs. Curr Opin Neurobiol 8:335\u2013344","journal-title":"Curr Opin Neurobiol"},{"key":"773_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.bbrc.2017.01.003","volume":"483","author":"AP Carneiro","year":"2017","unstructured":"Carneiro AP, Fonseca-Alaniz MH, Dallan LAO, Miyakawa AA, Krieger JE (2017) Beta-arrestin is critical for early shear stress-induced Akt\/eNOS activation in human vascular endothelial cells. Biochem Biophys Res Commun 483:75\u201381","journal-title":"Biochem Biophys Res Commun"},{"key":"773_CR33","doi-asserted-by":"publisher","first-page":"7250","DOI":"10.1158\/0008-5472.CAN-13-3583","volume":"74","author":"C Cekic","year":"2014","unstructured":"Cekic C, Day YJ, Sag D, Linden J (2014) Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. Cancer Res 74:7250\u20137259","journal-title":"Cancer Res"},{"key":"773_CR34","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/B978-0-12-411638-2.00002-1","volume":"124","author":"S Chatterjee","year":"2014","unstructured":"Chatterjee S, Behnam Azad B, Nimmagadda S (2014) The intricate role of CXCR4 in cancer. Adv Cancer Res 124:31\u201382","journal-title":"Adv Cancer Res"},{"key":"773_CR35","doi-asserted-by":"publisher","first-page":"28","DOI":"10.3390\/vaccines4030028","volume":"4","author":"B Chaudhary","year":"2016","unstructured":"Chaudhary B, Elkord E (2016) Regulatory T cells in the tumor microenvironment and Cancer progression: role and therapeutic targeting. Vaccines (Basel) 4:28","journal-title":"Vaccines (Basel)"},{"key":"773_CR36","doi-asserted-by":"publisher","first-page":"3288","DOI":"10.3390\/cells10123288","volume":"10","author":"PK Chaudhary","year":"2021","unstructured":"Chaudhary PK, Kim S (2021) An insight into GPCR and G-proteins as Cancer drivers. Cells 10:3288","journal-title":"Cells"},{"key":"773_CR37","doi-asserted-by":"publisher","first-page":"4558","DOI":"10.1073\/pnas.1815515116","volume":"116","author":"IX Chen","year":"2019","unstructured":"Chen IX, Chauhan VP, Posada J, Ng MR, Wu MW, Adstamongkonkul P, Huang P, Lindeman N, Langer R, Jain RK (2019) Blocking CXCR4 alleviates desmoplasia, increases T-lymphocyte infiltration, and improves immunotherapy in metastatic breast cancer. Proc Natl Acad Sci USA 116:4558\u20134566","journal-title":"Proc Natl Acad Sci USA"},{"key":"773_CR38","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.3390\/genes14051008","volume":"14","author":"C Chen","year":"2023","unstructured":"Chen C, Liu X, Chang CY, Wang HY, Wang RF (2023) The interplay between T cells and Cancer: the basis of immunotherapy. Genes (Basel) 14:1008","journal-title":"Genes (Basel)"},{"key":"773_CR39","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1189\/jlb.0908551","volume":"86","author":"R Cheung","year":"2009","unstructured":"Cheung R, Malik M, Ravyn V, Tomkowicz B, Ptasznik A, Collman RG (2009) An arrestin-dependent multi-kinase signaling complex mediates MIP-1beta\/CCL4 signaling and chemotaxis of primary human macrophages. J Leukoc Biol 86:833\u2013845","journal-title":"J Leukoc Biol"},{"key":"773_CR40","doi-asserted-by":"crossref","unstructured":"Chu YD, Yeh CT (2020) The molecular function and clinical role of thyroid stimulating hormone receptor in Cancer cells. Cells 9","DOI":"10.3390\/cells9071730"},{"key":"773_CR41","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.lfs.2014.01.078","volume":"118","author":"R Cianfrocca","year":"2014","unstructured":"Cianfrocca R, Tocci P, Semprucci E, Spinella F, Di Castro V, Bagnato A, Rosano L (2014) Beta-Arrestin 1 is required for endothelin-1-induced NF-kappaB activation in ovarian cancer cells. Life Sci 118:179\u2013184","journal-title":"Life Sci"},{"key":"773_CR42","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1158\/1078-0432.CCR-11-0641","volume":"18","author":"SW Cole","year":"2012","unstructured":"Cole SW, Sood AK (2012) Molecular pathways: beta-adrenergic signaling in cancer. Clin Cancer Res 18:1201\u20131206","journal-title":"Clin Cancer Res"},{"key":"773_CR43","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.tips.2020.10.001","volume":"41","author":"AC Cornwell","year":"2020","unstructured":"Cornwell AC, Feigin ME (2020) Unintended effects of GPCR-targeted drugs on the Cancer phenotype. Trends Pharmacol Sci 41:1006\u20131022","journal-title":"Trends Pharmacol Sci"},{"key":"773_CR44","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1124\/molpharm.124.000942","volume":"106","author":"JM Crecelius","year":"2024","unstructured":"Crecelius JM, Manz AR, Benzow S, Marchese A (2024) Receptor determinants for beta-Arrestin functional specificity at C-X-C chemokine receptor 5. Mol Pharmacol 106:287\u2013297","journal-title":"Mol Pharmacol"},{"key":"773_CR45","doi-asserted-by":"crossref","unstructured":"Crudden C, Song D, Cismas S, Trocme E, Pasca S, Calin GA, Girnita A, Girnita L (2019) Below the surface: IGF-1R therapeutic targeting and its endocytic journey. Cells 8","DOI":"10.3390\/cells8101223"},{"key":"773_CR46","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.550824","volume":"11","author":"G D\u2019Agostino","year":"2020","unstructured":"D\u2019Agostino G, Artinger M, Locati M, Perez L, Legler DF, Bianchi ME, Ruegg C, Thelen M, Marchese A, Rocchi MBL, Cecchinato V, Uguccioni M (2020) Beta-Arrestin1 and beta-Arrestin2 are required to support the activity of the CXCL12\/HMGB1 Heterocomplex on CXCR4. Front Immunol 11:550824","journal-title":"Front Immunol"},{"key":"773_CR47","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","volume":"41","author":"KE de Visser","year":"2023","unstructured":"de Visser KE, Joyce JA (2023) The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth. Cancer Cell 41:374\u2013403","journal-title":"Cancer Cell"},{"key":"773_CR48","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1146\/annurev.physiol.69.022405.154804","volume":"69","author":"KA DeFea","year":"2007","unstructured":"DeFea KA (2007) Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization. Annu Rev Physiol 69:535\u2013560","journal-title":"Annu Rev Physiol"},{"key":"773_CR49","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1038\/s41419-024-06730-6","volume":"15","author":"D Del Rio","year":"2024","unstructured":"Del Rio D, Masi I, Caprara V, Ottavi F, Albertini Petroni G, Salvati E, Trisciuoglio D, Giannitelli SM, Bagnato A, Mauri E, Spadaro F, Rosano L (2024) The beta-arrestin1\/endothelin axis bolsters ovarian fibroblast-dependent invadosome activity and cancer cell metastatic potential. Cell Death Dis 15:358","journal-title":"Cell Death Dis"},{"key":"773_CR50","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41571-021-00549-2","volume":"19","author":"R Dhanasekaran","year":"2022","unstructured":"Dhanasekaran R, Auid-Orcid Deutzmann A, Mahauad-Fernandez WD, Auid-Orcid Hansen AS, Gouw AM, Felsher DW (2022) The MYC oncogene \u2013 the grand orchestrator of cancer growth and immune evasion. Nat Rev Clin Oncol 19:23\u201336","journal-title":"Nat Rev Clin Oncol"},{"key":"773_CR51","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1007\/s00262-024-03801-7","volume":"73","author":"K Dickinson","year":"2024","unstructured":"Dickinson K, Yee EJ, Vigil I, Schulick RD, Zhu Y (2024) GPCRs: emerging targets for novel T cell immune checkpoint therapy. Cancer Immunol Immunother 73:253","journal-title":"Cancer Immunol Immunother"},{"key":"773_CR52","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1212\/CON.0000000000000943","volume":"26","author":"J Dietrich","year":"2020","unstructured":"Dietrich J (2020) Neurotoxicity of Cancer therapies. Continuum (Minneap Minn) 26:1646\u20131672","journal-title":"Continuum (Minneap Minn)"},{"key":"773_CR53","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1038\/s41419-025-07507-1","volume":"16","author":"YF Ding","year":"2025","unstructured":"Ding YF, Ho KH, Lee WJ, Chen LH, Hsieh FK, Tung MC, Lin SH, Hsiao M, Yang SF, Yang YC, Chien MH (2025) Cyclic increase in the histamine receptor H1-ADAM9-snail\/slug axis as a potential therapeutic target for EMT-mediated progression of oral squamous cell carcinoma. Cell Death Dis 16:191","journal-title":"Cell Death Dis"},{"key":"773_CR54","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.ejca.2012.05.005","volume":"49","author":"UM Domanska","year":"2013","unstructured":"Domanska UM, Kruizinga RC, Nagengast WB, Timmer-Bosscha H, Huls G, de Vries EG, Walenkamp AM (2013) A review on CXCR4\/CXCL12 axis in oncology: no place to hide. Eur J Cancer 49:219\u2013230","journal-title":"Eur J Cancer"},{"key":"773_CR55","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.biopsych.2016.09.025","volume":"81","author":"JH Dong","year":"2017","unstructured":"Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, Yang F, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Yi F, Lin A, Kahsai AW, Cahill TJ 3rd, Chen ZY, Yu X, Sun JP (2017) Adaptive activation of a stress response pathway improves learning and memory through Gs and beta-Arrestin-1-regulated lactate metabolism. Biol Psychiatry 81:654\u2013670","journal-title":"Biol Psychiatry"},{"key":"773_CR56","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41467-024-45167-5","volume":"15","author":"T Dong","year":"2024","unstructured":"Dong T, Hu G, Fan Z, Wang H, Gao Y, Wang S, Xu H, Yaffe MB, Vander Heiden MG, Lv G, Chen J (2024) Activation of GPR3-beta-arrestin2-PKM2 pathway in Kupffer cells stimulates glycolysis and inhibits obesity and liver pathogenesis. Nat Commun 15:807","journal-title":"Nat Commun"},{"key":"773_CR57","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301091","volume":"37","author":"NV Dwivedi","year":"2023","unstructured":"Dwivedi NV, Datta S, El-Kersh K, Sadikot RT, Ganti AK, Batra SK, Jain M (2023) GPCRs and fibroblast heterogeneity in fibroblast-associated diseases. FASEB J 37:e23101","journal-title":"FASEB J"},{"key":"773_CR58","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1177\/1087057114557233","volume":"20","author":"H Eishingdrelo","year":"2014","unstructured":"Eishingdrelo H, Sun W, Li H, Wang L, Eishingdrelo A, Dai S, McKew JC, Zheng W (2014) ERK and \u03b2-Arrestin interaction: a converging point of signaling pathways for multiple types of cell surface receptors. J Biomol Screen 20:341\u2013349","journal-title":"J Biomol Screen"},{"issue":"1","key":"773_CR59","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.canlet.2012.08.018","volume":"328","author":"E Fagiani","year":"2013","unstructured":"Fagiani E, Christofori G (2013) Angiopoietins in angiogenesis. Cancer Lett 328(1):18\u201326. https:\/\/doi.org\/10.1016\/j.canlet.2012.08.018","journal-title":"Cancer Lett"},{"key":"773_CR60","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1177\/1753425913501098","volume":"20","author":"H Fan","year":"2014","unstructured":"Fan H (2014) Beta-Arrestins 1 and 2 are critical regulators of inflammation. Innate Immun 20:451\u2013460","journal-title":"Innate Immun"},{"key":"773_CR61","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41418-020-00704-9","volume":"28","author":"Y Fang","year":"2021","unstructured":"Fang Y, Jiang Q, Li S, Zhu H, Rong X, Song N, Ding X, Liu J, Chen M, Song M, Ding J, Ming L, Guangyu W, Gang H (2021) Opposing functions of \u03b2-arrestin 1 and 2 in Parkinson\u2019s disease via microglia inflammation and Nprl3. Cell Death Differ 28:1822\u20131836","journal-title":"Cell Death Differ"},{"key":"773_CR62","doi-asserted-by":"publisher","first-page":"8870","DOI":"10.1038\/s41598-021-85408-x","volume":"11","author":"DM Favara","year":"2021","unstructured":"Favara DM, Liebscher I, Jazayeri A, Nambiar M, Sheldon H, Banham AH, Harris AL (2021) Elevated expression of the adhesion GPCR ADGRL4\/ELTD1 promotes endothelial sprouting angiogenesis without activating canonical GPCR signalling. Sci Rep 11:8870","journal-title":"Sci Rep"},{"key":"773_CR63","doi-asserted-by":"publisher","unstructured":"Feitelson MA, Arzumanyan A, Kulathinal RJ, Blain SW, Holcombe RF, Mahajna J, Marino M, Martinez-Chantar ML, Nawroth R, Sanchez-Garcia I, Sharma D, Saxena NK, Singh N, Vlachostergios PJ, Guo S, Honoki K, Fujii H, Georgakilas AG, Bilsland A, Amedei A, Niccolai E, Amin A, Ashraf SS, Boosani CS, Guha G, Ciriolo MR, Aquilano K, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Keith WN, Nowsheen S (2015) Sustained proliferation in cancer: mechanisms and novel therapeutic targets. Semin Cancer Biol. https:\/\/doi.org\/10.1016\/j.semcancer.2015.02.006","DOI":"10.1016\/j.semcancer.2015.02.006"},{"key":"773_CR64","doi-asserted-by":"publisher","first-page":"7478","DOI":"10.1073\/pnas.112198299","volume":"99","author":"AM Fong","year":"2002","unstructured":"Fong AM, Premont RT, Richardson RM, Yu Y-RA, Lefkowitz RJ, Patel DD (2002) Defective lymphocyte chemotaxis in \u03b2-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci 99:7478\u20137483","journal-title":"Proc Natl Acad Sci"},{"key":"773_CR65","doi-asserted-by":"publisher","first-page":"8294","DOI":"10.18632\/aging.102320","volume":"11","author":"D Fu","year":"2019","unstructured":"Fu D, Li P, Sheng Q, Lv Z (2019) Beta-arrestin-2 enhances intestinal epithelial apoptosis in necrotizing enterocolitis. Aging (Albany NY) 11:8294\u20138312","journal-title":"Aging (Albany NY)"},{"key":"773_CR66","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1038\/jid.2014.117","volume":"134","author":"E Gaffal","year":"2014","unstructured":"Gaffal E, Jakobs M, Glodde N, Schr\u00f6der R, Kostenis E, T\u00fcting T (2014) \u03b2-Arrestin 2 inhibits Proinflammatory chemokine production and attenuates contact allergic inflammation in the skin. J Invest Dermatol 134:2131\u20132137","journal-title":"J Invest Dermatol"},{"key":"773_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2024.08.011","volume":"401","author":"F Gao","year":"2024","unstructured":"Gao F, Mu W, Fan J, Shen J (2024a) Beta-arrestin2 promotes angiogenesis of liver sinusoidal endothelial cells through the VEGF\/VEGFR2 pathway to aggravate cirrhosis. Toxicol Lett 401:1\u201312","journal-title":"Toxicol Lett"},{"key":"773_CR68","doi-asserted-by":"publisher","unstructured":"Gao PP, Li L, Chen TT, Li N, Li MQ, Zhang HJ, Chen YN, Zhang SH, Wei W, Sun WY (2024b) Beta-arrestin2: an emerging player and potential therapeutic target in inflammatory immune diseases. Acta Pharmacol Sin. https:\/\/doi.org\/10.1038\/s41401-024-01390-w","DOI":"10.1038\/s41401-024-01390-w"},{"key":"773_CR69","doi-asserted-by":"publisher","first-page":"8837640","DOI":"10.1155\/mi\/8837640","volume":"2025","author":"X Gao","year":"2025","unstructured":"Gao X, Jing D, Zhang Y, Zhu F, Yang Y, Zhou G (2025) Unveiling the role of GRK2: from immune regulation to Cancer therapeutics. Mediat Inflamm 2025:8837640","journal-title":"Mediat Inflamm"},{"key":"773_CR70","doi-asserted-by":"publisher","first-page":"34418","DOI":"10.1074\/jbc.M300573200","volume":"278","author":"L Ge","year":"2003","unstructured":"Ge L, Ly Y, Hollenberg M, DeFea K (2003) A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. J Biol Chem 278:34418\u201334426","journal-title":"J Biol Chem"},{"key":"773_CR71","doi-asserted-by":"publisher","first-page":"55419","DOI":"10.1074\/jbc.M410312200","volume":"279","author":"L Ge","year":"2004","unstructured":"Ge L, Shenoy SK, Lefkowitz RJ, DeFea K (2004) Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. J Biol Chem 279:55419\u201355424","journal-title":"J Biol Chem"},{"key":"773_CR72","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1158\/2326-6066.CIR-18-0763","volume":"7","author":"Y Ge","year":"2019","unstructured":"Ge Y, Bohm HH, Rathinasamy A, Xydia M, Hu X, Pincha M, Umansky L, Breyer C, Hillier M, Bonertz A, Sevko A, Domschke C, Schuetz F, Frebel H, Dettling S, Herold-Mende C, Reissfelder C, Weitz J, Umansky V, Beckhove P (2019) Tumor-specific regulatory T cells from the bone marrow orchestrate antitumor immunity in breast Cancer. Cancer Immunol Res 7:1998\u20132012","journal-title":"Cancer Immunol Res"},{"key":"773_CR73","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41392-020-00367-5","volume":"6","author":"LHM Geraldo","year":"2021","unstructured":"Geraldo LHM, Tcls Spohr RFD, Amaral AF, Garcia C, Mendes FA, Freitas C, dosSantos MF, Lima FRS (2021) Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies. Signal Transduct Target Ther 6:45","journal-title":"Signal Transduct Target Ther"},{"key":"773_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175586","volume":"949","author":"S Ghalehbandi","year":"2023","unstructured":"Ghalehbandi S, Yuzugulen J, Pranjol MZI, Pourgholami MH (2023) The role of VEGF in cancer-induced angiogenesis and research progress of drugs targeting VEGF. Eur J Pharmacol 949:175586","journal-title":"Eur J Pharmacol"},{"key":"773_CR75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/bs.mcb.2015.10.007","volume":"132","author":"A Gidon","year":"2016","unstructured":"Gidon A, Feinstein TN, Xiao K, Vilardaga JP (2016) Studying the regulation of endosomal cAMP production in GPCR signaling. Methods Cell Biol 132:109\u2013126","journal-title":"Methods Cell Biol"},{"key":"773_CR76","doi-asserted-by":"publisher","first-page":"2000","DOI":"10.1158\/0008-5472.CAN-08-2360","volume":"69","author":"M Gobert","year":"2009","unstructured":"Gobert M, Treilleux I, Bendriss-Vermare N, Bachelot T, Goddard-Leon S, Arfi V, Biota C, Doffin AC, Durand I, Olive D, Perez S, Pasqual N, Faure C, Ray-Coquard I, Puisieux A, Caux C, Blay JY, Menetrier-Caux C (2009) Regulatory T cells recruited through CCL22\/CCR4 are selectively activated in lymphoid infiltrates surrounding primary breast tumors and lead to an adverse clinical outcome. Cancer Res 69:2000\u20132009","journal-title":"Cancer Res"},{"key":"773_CR77","doi-asserted-by":"crossref","unstructured":"Habrowska-Gorczynska DE, Koziel MJ, Kowalska K, Piastowska-Ciesielska AW (2021) FOXO3a and its regulators in prostate Cancer. Int J Mol Sci 22","DOI":"10.3390\/ijms222212530"},{"key":"773_CR78","doi-asserted-by":"publisher","first-page":"RP99373","DOI":"10.7554\/eLife.99373","volume":"13","author":"H Hahn","year":"2025","unstructured":"Hahn H, Daly C, Little J 4th, Perry-Hauser NA, Flores-Espinoza E, Inoue A, Plouffe B, Thomsen ARB (2025) Endosomal chemokine receptor signalosomes regulate central mechanisms underlying cell migration. elife 13:RP99373","journal-title":"elife"},{"key":"773_CR79","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fonc.2020.00221","volume":"10","author":"Y Haibe","year":"2020","unstructured":"Haibe Y, Kreidieh M, El Hajj H, Khalifeh I, Mukherji D, Temraz S, Shamseddine A (2020) Resistance mechanisms to anti-angiogenic therapies in Cancer. Front Oncol 10:221","journal-title":"Front Oncol"},{"key":"773_CR80","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.ccell.2016.12.006","volume":"31","author":"CJ Halbrook","year":"2017","unstructured":"Halbrook CJ, Lyssiotis CA (2017) Employing metabolism to improve the diagnosis and treatment of pancreatic Cancer. Cancer Cell 31:5\u201319","journal-title":"Cancer Cell"},{"key":"773_CR81","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3892\/ol.2011.291","volume":"2","author":"N Han","year":"2011","unstructured":"Han N, Jin K, He K, Cao J, Teng L (2011) Protease-activated receptors in cancer: A systematic review. Oncol Lett 2:599\u2013608","journal-title":"Oncol Lett"},{"key":"773_CR82","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","volume":"12","author":"D Hanahan","year":"2022","unstructured":"Hanahan D (2022) Hallmarks of Cancer: new dimensions. Cancer Discov 12:31\u201346","journal-title":"Cancer Discov"},{"key":"773_CR83","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100:57\u201370","journal-title":"Cell"},{"key":"773_CR84","doi-asserted-by":"publisher","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","volume":"144","author":"D Hanahan","year":"2011","unstructured":"Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646\u2013674","journal-title":"Cell"},{"key":"773_CR85","doi-asserted-by":"crossref","unstructured":"Harrison M, Zinovkin D, Pranjol MZI (2024) Endothelin-1 and its role in Cancer and potential therapeutic opportunities. Biomedicine 12","DOI":"10.3390\/biomedicines12030511"},{"key":"773_CR86","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1038\/nrd.2017.178","volume":"16","author":"AS Hauser","year":"2017","unstructured":"Hauser AS, Attwood MM, Rask-Andersen M, Schioth HB, Gloriam DE (2017) Trends in GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov 16:829\u2013842","journal-title":"Nat Rev Drug Discov"},{"issue":"41\u201354","key":"773_CR87","volume":"172","author":"AS Hauser","year":"2018","unstructured":"Hauser AS, Chavali S, Masuho I, Jahn LJ, Martemyanov KA, Gloriam DE, Babu MM (2018) Pharmacogenomics of GPCR drug targets. Cell 172(41\u201354):e19","journal-title":"Cell"},{"key":"773_CR88","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1007\/s10875-010-9492-4","volume":"31","author":"Z Hu","year":"2011","unstructured":"Hu Z, Huang Y, Liu Y, Sun Y, Zhou Y, Gu M, Chen Y, Xia R, Chen S, Deng A, Zhong R (2011) beta-Arrestin 1 modulates functions of autoimmune T cells from primary biliary cirrhosis patients. J Clin Immunol 31:346\u2013355","journal-title":"J Clin Immunol"},{"key":"773_CR89","doi-asserted-by":"publisher","unstructured":"Hu S, Wang D, Wu J, Jin J, Wei W, Sun W (2013) Involvement of \u03b2-arrestins in cancer progression. Mol Biol Rep. https:\/\/doi.org\/10.1007\/s11033-012-2148-0","DOI":"10.1007\/s11033-012-2148-0"},{"key":"773_CR90","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1186\/s12943-025-02336-4","volume":"24","author":"S Huang","year":"2025","unstructured":"Huang S, Zhu J, Yu L, Huang Y, Hu Y (2025) Cancer-nervous system crosstalk: from biological mechanism to therapeutic opportunities. Mol Cancer 24:133","journal-title":"Mol Cancer"},{"key":"773_CR91","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1111\/febs.14466","volume":"285","author":"CE Hughes","year":"2018","unstructured":"Hughes CE, Nibbs RJB (2018) A guide to chemokines and their receptors. FEBS J 285:2944\u20132971","journal-title":"FEBS J"},{"key":"773_CR92","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1124\/mol.104.006270","volume":"67","author":"DL Hunton","year":"2005","unstructured":"Hunton DL, Barnes WG, Kim J, Ren X-R, Violin JD, Reiter E, Milligan G, Patel DD, Lefkowitz RJ (2005) \u03b2-arrestin 2-dependent angiotensin II type 1A receptor-mediated pathway of chemotaxis. Mol Pharmacol 67:1229\u20131236","journal-title":"Mol Pharmacol"},{"key":"773_CR93","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.cmet.2017.03.008","volume":"25","author":"AS Husted","year":"2017","unstructured":"Husted AS, Trauelsen M, Rudenko O, Hjorth SA, Schwartz TW (2017) GPCR-mediated signaling of metabolites. Cell Metab 25:777\u2013796","journal-title":"Cell Metab"},{"key":"773_CR94","doi-asserted-by":"publisher","first-page":"2517","DOI":"10.1007\/s00018-013-1498-7","volume":"71","author":"M Jaber","year":"2014","unstructured":"Jaber M, Maoz M, Kancharla A, Agranovich D, Peretz T, Grisaru-Granovsky S, Uziely B, Bar-Shavit R (2014) Protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer. Cell Mol Life Sci 71:2517\u20132533","journal-title":"Cell Mol Life Sci"},{"key":"773_CR95","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1007\/s00018-016-2424-6","volume":"74","author":"M Jaber","year":"2017","unstructured":"Jaber M, Maoz M, Kancharla A, Agranovich D, Peretz T, Grisaru-Granovsky S, Uziely B, Bar-Shavit R (2017) Erratum to: protease-activated-receptor-2 affects protease-activated-receptor-1-driven breast cancer. Cell Mol Life Sci 74:571\u2013577","journal-title":"Cell Mol Life Sci"},{"key":"773_CR96","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2025.108806","volume":"269","author":"T Jayakody","year":"2025","unstructured":"Jayakody T, Budagoda DK, Mendis K, Dilshan WD, Bethmage D, Dissasekara R, Dawe GS (2025) Biased agonism in peptide-GPCRs: A structural perspective. Pharmacol Ther 269:108806","journal-title":"Pharmacol Ther"},{"key":"773_CR97","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1097\/FJC.0000000000000482","volume":"70","author":"PY Jean-Charles","year":"2017","unstructured":"Jean-Charles PY, Sudha K, Shenoy SK (2017) G protein-coupled receptor signaling through \u03b2-arrestin-dependent mechanisms. J Cardiovasc Pharmacol 70:142\u2013158. https:\/\/doi.org\/10.1097\/FJC.0000000000000482","journal-title":"J Cardiovasc Pharmacol"},{"key":"773_CR98","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/B978-0-12-394440-5.00014-0","volume":"118","author":"D Jiang","year":"2013","unstructured":"Jiang D, Xie T, Liang J, Noble PW (2013) Beta-Arrestins in the immune system. Prog Mol Biol Transl Sci 118:359\u2013393","journal-title":"Prog Mol Biol Transl Sci"},{"key":"773_CR99","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41419-018-0299-1","volume":"9","author":"LP Jiang","year":"2018","unstructured":"Jiang LP, Fan SQ, Xiong QX, Zhou YC, Yang ZZ, Li GF, Huang YC, Wu MG, Shen QS, Liu K, Yang CP, Chen YB (2018) GRK5 functions as an oncogenic factor in non-small-cell lung cancer. Cell Death Dis 9:295","journal-title":"Cell Death Dis"},{"key":"773_CR100","doi-asserted-by":"publisher","first-page":"40606","DOI":"10.18632\/oncotarget.16506","volume":"8","author":"G Jin","year":"2017","unstructured":"Jin G, Sakitani K, Wang H, Jin Y, Dubeykovskiy A, Worthley DL, Tailor Y, Wang TC (2017) The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis. Oncotarget 8:40606\u201340619","journal-title":"Oncotarget"},{"key":"773_CR101","doi-asserted-by":"crossref","unstructured":"Kahsai AW, Pakharukova N, Kwon HY, Shah KS, Liang-Lin JG, Del Real CT, Shim PJ, Lee MA, Ngo VA, Shreiber BN, Liu S, Schwalb AM, Espinoza EF, Thomas BN, Kunzle CA, Smith JS, Wang J, Kim J, Zhang X, Rockman HA, Thomsen ARB, Rein LAM, Shi L, Ahn S, Masoudi A, Lefkowitz RJ (2025) Small-molecule modulation of beta-arrestins. bioRxiv","DOI":"10.1101\/2024.12.27.630464"},{"key":"773_CR102","doi-asserted-by":"publisher","unstructured":"Kallifatidis G, Mamouni K, Lokeshwar BL (2020) The role of \u03b2-Arrestins in regulating stem cell phenotypes in Normal and tumorigenic cells. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms21239310","DOI":"10.3390\/ijms21239310"},{"key":"773_CR103","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.1158\/1078-0432.CCR-08-0543","volume":"15","author":"LE Kandalaft","year":"2009","unstructured":"Kandalaft LE, Facciabene A, Buckanovich RJ, Coukos G (2009) Endothelin B receptor, a new target in cancer immune therapy. Clin Cancer Res 15:4521\u20134528","journal-title":"Clin Cancer Res"},{"key":"773_CR104","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.cell.2005.09.011","volume":"123","author":"J Kang","year":"2005","unstructured":"Kang J, Shi Y, Xiang B, Qu B, Su W, Zhu M, Zhang M, Bao G, Wang F, Zhang X, Yang R, Fan F, Chen X, Pei G, Ma L (2005) A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. Cell 123:833\u2013847","journal-title":"Cell"},{"key":"773_CR105","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/s41419-019-1375-x","volume":"10","author":"H Kanki","year":"2019","unstructured":"Kanki H, Sasaki T, Matsumura S, Yokawa S, Yukami T, Shimamura M, Sakaguchi M, Furuno T, Suzuki T, Mochizuki H (2019) Beta-arrestin-2 in PAR-1-biased signaling has a crucial role in endothelial function via PDGF-beta in stroke. Cell Death Dis 10:100","journal-title":"Cell Death Dis"},{"key":"773_CR106","first-page":"1781","volume":"16","author":"A Kaparianos","year":"2012","unstructured":"Kaparianos A, Argyropoulou E, Spiropoulos K (2012) The role of Beta-arrestins in respiratory pathophysiology and tumorigenesis: going a step beyond the cell surface. Eur Rev Med Pharmacol Sci 16:1781\u20131794","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"773_CR107","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1038\/s42003-020-01504-0","volume":"3","author":"AJ Kennedy","year":"2020","unstructured":"Kennedy AJ, Sundstrom L, Geschwindner S, Poon EKY, Jiang Y, Chen R, Cooke R, Johnstone S, Madin A, Lim J, Liu Q, Lohman RJ, Nordqvist A, Friden-Saxin M, Yang W, Brown DG, Fairlie DP, Dekker N (2020) Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition. Commun Biol 3:782","journal-title":"Commun Biol"},{"key":"773_CR108","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1158\/1541-7786.MCR-09-0511","volume":"8","author":"JI Kim","year":"2010","unstructured":"Kim JI, Lakshmikanthan V, Frilot N, Daaka Y (2010) Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. Mol Cancer Res 8:569\u2013577","journal-title":"Mol Cancer Res"},{"key":"773_CR109","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1038\/s41419-023-05945-3","volume":"14","author":"JY Kim","year":"2023","unstructured":"Kim JY, Shin JH, Kim MJ, Kang Y, Lee JS, Son J, Jeong SK, Kim D, Kim DH, Chun E, Lee KY (2023) Beta-arrestin 2 negatively regulates lung cancer progression by inhibiting the TRAF6 signaling axis for NF-kappaB activation and autophagy induced by TLR3 and TLR4. Cell Death Dis 14:422","journal-title":"Cell Death Dis"},{"key":"773_CR110","doi-asserted-by":"crossref","unstructured":"Klussmeier A, Aurich S, Niederstadt L, Wiedenmann B, Grotzinger C (2022) Secretin receptor as a target in gastrointestinal Cancer: expression analysis and ligand development. Biomedicine 10","DOI":"10.1101\/2022.01.31.478443"},{"key":"773_CR111","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.1111\/cas.13619","volume":"109","author":"Z Kong","year":"2018","unstructured":"Kong Z, Deng T, Zhang M, Zhao Z, Liu Y, Luo L, Cai C, Wu W, Duan X (2018) Beta-arrestin1-medieated inhibition of FOXO3a contributes to prostate cancer cell growth in vitro and in vivo. Cancer Sci 109:1834\u20131842","journal-title":"Cancer Sci"},{"key":"773_CR112","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1007\/978-3-642-41199-1_16","volume":"219","author":"S Kook","year":"2014","unstructured":"Kook S, Gurevich VV, Gurevich EV (2014) Arrestins in apoptosis. Handb Exp Pharmacol 219:309\u2013339","journal-title":"Handb Exp Pharmacol"},{"key":"773_CR113","doi-asserted-by":"crossref","unstructured":"Korbecki J, Kupnicka P, Barczak K, Bosiacki M, Zietek P, Chlubek D, Baranowska-Bosiacka I (2023) The role of CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 ligands in molecular cancer processes and clinical aspects of acute myeloid leukemia (AML). Cancers (Basel) 15","DOI":"10.3390\/cancers15184555"},{"key":"773_CR114","first-page":"259","volume":"9","author":"C Kourek","year":"2022","unstructured":"Kourek C, Touloupaki M, Rempakos A, Loritis K, Tsougkos E, Paraskevaidis I, Briasoulis A (2022) Cardioprotective strategies from cardiotoxicity in Cancer patients: a comprehensive review. J Cardiovasc Dev Dis 9:259","journal-title":"J Cardiovasc Dev Dis"},{"key":"773_CR115","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.1158\/0008-5472.CAN-05-0216","volume":"65","author":"K Krysan","year":"2005","unstructured":"Krysan K, Reckamp KL, Dalwadi H, Sharma S, Rozengurt E, Dohadwala M, Dubinett SM (2005) Prostaglandin E2 activates mitogen-activated protein kinase\/Erk pathway signaling and cell proliferation in non-small cell lung cancer cells in an epidermal growth factor receptor-independent manner. Cancer Res 65:6275\u20136281","journal-title":"Cancer Res"},{"key":"773_CR116","doi-asserted-by":"crossref","unstructured":"Kulik G (2019) ADRB2-targeting therapies for prostate Cancer. Cancers (Basel) 11","DOI":"10.3390\/cancers11030358"},{"key":"773_CR117","doi-asserted-by":"publisher","first-page":"e473","DOI":"10.1016\/j.bja.2020.09.021","volume":"125","author":"D Lambert","year":"2020","unstructured":"Lambert D, Calo G (2020) Approval of oliceridine (TRV130) for intravenous use in moderate to severe pain in adults. Br J Anaesth 125:e473\u2013ee74","journal-title":"Br J Anaesth"},{"key":"773_CR118","doi-asserted-by":"crossref","unstructured":"Lappano R, Maggiolini M (2023) Role of the G protein-coupled receptors in Cancer and stromal cells: from functions to novel therapeutic perspectives. Cells 12","DOI":"10.3390\/cells12040626"},{"key":"773_CR119","doi-asserted-by":"publisher","first-page":"21507","DOI":"10.1074\/jbc.M700176200","volume":"282","author":"NY Lee","year":"2007","unstructured":"Lee NY, Blobe GC (2007) The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells. J Biol Chem 282:21507\u201321517","journal-title":"J Biol Chem"},{"key":"773_CR120","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3390\/biom11010009","volume":"11","author":"C Lee","year":"2020","unstructured":"Lee C, Viswanathan G, Choi I, Jassal C, Kohlmann T, Rajagopal S (2020) Beta-Arrestins and receptor signaling in the vascular endothelium. Biomolecules 11:9","journal-title":"Biomolecules"},{"key":"773_CR121","doi-asserted-by":"publisher","first-page":"E133","DOI":"10.1038\/35017152","volume":"2","author":"RJ Lefkowitz","year":"2000","unstructured":"Lefkowitz RJ (2000) The superfamily of heptahelical receptors. Nat Cell Biol 2:E133\u2013E136","journal-title":"Nat Cell Biol"},{"key":"773_CR122","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/j.1365-201X.2007.01693.x","volume":"190","author":"RJ Lefkowitz","year":"2007","unstructured":"Lefkowitz RJ (2007) Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf) 190:9\u201319","journal-title":"Acta Physiol (Oxf)"},{"key":"773_CR123","doi-asserted-by":"publisher","first-page":"6366","DOI":"10.1002\/anie.201301924","volume":"52","author":"RJ Lefkowitz","year":"2013","unstructured":"Lefkowitz RJ (2013) A brief history of G-protein coupled receptors (Nobel Lecture). Angew Chem Int Ed Engl 52:6366\u20136378","journal-title":"Angew Chem Int Ed Engl"},{"key":"773_CR124","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1126\/science.1109237","volume":"308","author":"RJ Lefkowitz","year":"2005","unstructured":"Lefkowitz RJ, Shenoy SK (2005) Transduction of receptor signals by beta-arrestins. Science 308:512\u2013517","journal-title":"Science"},{"key":"773_CR125","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.molimm.2011.07.021","volume":"49","author":"P Li","year":"2011","unstructured":"Li P, Cook JA, Gilkeson GS, Luttrell LM, Wang L, Borg KT, Halushka PV, Fan H (2011) Increased expression of beta-arrestin 1 and 2 in murine models of rheumatoid arthritis: isoform specific regulation of inflammation. Mol Immunol 49:64\u201374","journal-title":"Mol Immunol"},{"issue":"36\u201352","key":"773_CR126","volume":"40","author":"H Li","year":"2022","unstructured":"Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, Kuo WL, Halpin A, Gibbons DL, Yagita H, Zhao Z, Pang D, Ren G, Yee C, Lee JJ, Yu D (2022) The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell 40(36\u201352):e9","journal-title":"Cancer Cell"},{"key":"773_CR127","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1186\/s12935-024-03535-7","volume":"24","author":"KR Limbu","year":"2024","unstructured":"Limbu KR, Chhetri RB, Kim S, Shrestha J, Oh YS, Baek DJ, Park EY (2024) Targeting sphingosine 1-phosphate and sphingosine kinases in pancreatic cancer: mechanisms and therapeutic potential. Cancer Cell Int 24:353","journal-title":"Cancer Cell Int"},{"key":"773_CR128","doi-asserted-by":"crossref","unstructured":"Lin YH, Lin YC, Chen CC (2021) Lysophosphatidic acid receptor antagonists and Cancer: the current trends, clinical implications, and trials. Cells 10","DOI":"10.3390\/cells10071629"},{"key":"773_CR129","doi-asserted-by":"publisher","first-page":"1030831","DOI":"10.3389\/fimmu.2022.1030831","volume":"13","author":"Y Lin","year":"2022","unstructured":"Lin Y, Zhou X, Ni Y, Zhao X, Liang X (2022) Metabolic reprogramming of the tumor immune microenvironment in ovarian cancer: a novel orientation for immunotherapy. Front Immunol 13:1030831","journal-title":"Front Immunol"},{"key":"773_CR130","doi-asserted-by":"publisher","first-page":"1523751","DOI":"10.3389\/fonc.2025.1523751","volume":"15","author":"P Liu","year":"2025","unstructured":"Liu P, Sun Z (2025) Chemokines and their receptors in the esophageal carcinoma tumor microenvironment: key factors for metastasis and progression. Front Oncol 15:1523751","journal-title":"Front Oncol"},{"key":"773_CR131","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1038\/s41392-023-01460-1","volume":"8","author":"ZL Liu","year":"2023","unstructured":"Liu ZL, Chen HH, Zheng LL, Sun LP, Shi L (2023) Angiogenic signaling pathways and anti-angiogenic therapy for cancer. Signal Transduct Target Ther 8:198","journal-title":"Signal Transduct Target Ther"},{"key":"773_CR132","doi-asserted-by":"publisher","first-page":"2322","DOI":"10.4239\/wjd.v15.i12.2322","volume":"15","author":"J Liu","year":"2024","unstructured":"Liu J, Song XY, Li XT, Yang M, Wang F, Han Y, Jiang Y, Lei YX, Jiang M, Zhang W, Tang DQ (2024a) Beta-Arrestin-2 enhances endoplasmic reticulum stress-induced glomerular endothelial cell injury by activating transcription factor 6 in diabetic nephropathy. World J Diabetes 15:2322\u20132337","journal-title":"World J Diabetes"},{"key":"773_CR133","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1161\/CIRCRESAHA.124.323067","volume":"135","author":"S Liu","year":"2024","unstructured":"Liu S, Anderson PJ, Rajagopal S, Lefkowitz RJ, Rockman HA (2024b) G protein-coupled receptors: A century of research and discovery. Circ Res 135:174\u2013197","journal-title":"Circ Res"},{"key":"773_CR134","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1038\/s41573-025-01139-y","volume":"24","author":"JS Lorente","year":"2025","unstructured":"Lorente JS, Sokolov AV, Ferguson G, Schioth HB, Hauser AS, Gloriam DE (2025) GPCR drug discovery: new agents, targets and indications. Nat Rev Drug Discov 24:458\u2013479","journal-title":"Nat Rev Drug Discov"},{"key":"773_CR135","doi-asserted-by":"publisher","first-page":"74ra23","DOI":"10.1126\/scitranslmed.3001564","volume":"3","author":"AK Lovgren","year":"2011","unstructured":"Lovgren AK, Kovacs JJ, Xie T, Potts EN, Li Y, Foster WM, Liang J, Meltzer EB, Jiang D, Lefkowitz RJ, Noble PW (2011) Beta-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Sci Transl Med 3:74ra23","journal-title":"Sci Transl Med"},{"key":"773_CR136","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1007\/s00018-019-03351-7","volume":"77","author":"R Lugano","year":"2020","unstructured":"Lugano R, Ramachandran M, Dimberg A (2020) Tumor angiogenesis: causes, consequences, challenges and opportunities. Cell Mol Life Sci 77:1745\u20131770","journal-title":"Cell Mol Life Sci"},{"key":"773_CR137","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41419-024-07095-6","volume":"15","author":"Y Luo","year":"2024","unstructured":"Luo Y, Lu J, Lei Z, Rao D, Wang T, Fu C, Zhu H, Zhang Z, Liao Z, Liang H, Huang W (2024) GPR56 facilitates hepatocellular carcinoma metastasis by promoting the TGF-beta signaling pathway. Cell Death Dis 15:715","journal-title":"Cell Death Dis"},{"key":"773_CR138","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/s41571-023-00776-9","volume":"20","author":"MB Lustberg","year":"2023","unstructured":"Lustberg MB, Kuderer NM, Desai A, Bergerot C, Lyman GH (2023) Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship. Nat Rev Clin Oncol 20:527\u2013542","journal-title":"Nat Rev Clin Oncol"},{"key":"773_CR139","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1126\/science.283.5402.655","volume":"283","author":"LM Luttrell","year":"1999","unstructured":"Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ, Lin F, Kawakatsu H, Owada K, Luttrell DK, Caron MG, Lefkowitz RJ (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283:655\u2013661","journal-title":"Science"},{"key":"773_CR140","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1007\/s12094-022-03052-x","volume":"25","author":"J Lv","year":"2023","unstructured":"Lv J, Liu J, Chao G, Zhang S (2023) PARs in the inflammation-cancer transformation of CRC. Clin Transl Oncol 25:1242\u20131251","journal-title":"Clin Transl Oncol"},{"key":"773_CR141","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1242\/jcs.03338","volume":"120","author":"L Ma","year":"2007","unstructured":"Ma L, Pei G (2007) Beta-arrestin signaling and regulation of transcription. J Cell Sci 120:213\u2013218. https:\/\/doi.org\/10.1242\/jcs.03338","journal-title":"J Cell Sci"},{"key":"773_CR142","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1016\/j.febslet.2008.03.039","volume":"582","author":"LM Machesky","year":"2008","unstructured":"Machesky LM (2008) Lamellipodia and filopodia in metastasis and invasion. FEBS Lett 582:2102\u20132111","journal-title":"FEBS Lett"},{"key":"773_CR143","first-page":"1461","volume":"19","author":"S Maekawa","year":"2008","unstructured":"Maekawa S, Iwasaki A, Shirakusa T, Kawakami T, Yanagisawa J, Tanaka T, Shibaguchi H, Kinugasa T, Kuroki M, Kuroki M (2008) Association between the expression of chemokine receptors CCR7 and CXCR3, and lymph node metastatic potential in lung adenocarcinoma. Oncol Rep 19:1461\u20131468","journal-title":"Oncol Rep"},{"key":"773_CR144","doi-asserted-by":"crossref","unstructured":"Mamouni K, Kim J, Lokeshwar BL, Kallifatidis G (2021) ARRB1 regulates metabolic reprogramming to promote glycolysis in stem cell-like bladder Cancer cells. Cancers (Basel) 13","DOI":"10.3390\/cancers13081809"},{"key":"773_CR145","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1080\/13543784.2024.2388567","volume":"33","author":"EA Martino","year":"2024","unstructured":"Martino EA, Bruzzese A, Labanca C, Mendicino F, Lucia E, Olivito V, Stanzione G, Zimbo A, Pozzi S, Neri A, Morabito F, Vigna E, Gentile M (2024) Investigational CXCR4 inhibitors in early phase development for the treatment of hematological malignancies. Expert Opin Investig Drugs 33:915\u2013924","journal-title":"Expert Opin Investig Drugs"},{"key":"773_CR146","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/978-3-642-41199-1_17","volume":"219","author":"KW McGovern","year":"2014","unstructured":"McGovern KW, DeFea KA (2014) Molecular mechanisms underlying beta-arrestin-dependent chemotaxis and actin-cytoskeletal reorganization. Handb Exp Pharmacol 219:341\u2013359","journal-title":"Handb Exp Pharmacol"},{"key":"773_CR147","doi-asserted-by":"publisher","unstructured":"Mo W, Zhang L, Yang G, Zhai J, Hu Z, Chen Y, Chen X, Hui L, Huang R, Hu G (2008) Nuclear beta-arrestin1 functions as a scaffold for the dephosphorylation of STAT1 and moderates the antiviral activity of IFN-gamma. Mol Cell. https:\/\/doi.org\/10.1016\/j.molcel.2008.06.017","DOI":"10.1016\/j.molcel.2008.06.017"},{"key":"773_CR148","doi-asserted-by":"publisher","first-page":"1494411","DOI":"10.3389\/fendo.2025.1494411","volume":"16","author":"L Molina Calistro","year":"2025","unstructured":"Molina Calistro L, Arancibia Y, Olivera MA, Domke S, Torres RF (2025) Interaction of GPER-1 with the endocrine signaling axis in breast cancer. Front Endocrinol (Lausanne) 16:1494411","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1613\u201330","key":"773_CR149","volume":"56","author":"MA Moreno Ayala","year":"2023","unstructured":"Moreno Ayala MA, Campbell TF, Zhang C, Dahan N, Bockman A, Prakash V, Feng L, Sher T, DuPage M (2023) CXCR3 expression in regulatory T cells drives interactions with type I dendritic cells in tumors to restrict CD8(+) T cell antitumor immunity. Immunity 56(1613\u201330):e5","journal-title":"Immunity"},{"key":"773_CR150","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117534","volume":"249","author":"K Mortezaee","year":"2020","unstructured":"Mortezaee K (2020) CXCL12\/CXCR4 axis in the microenvironment of solid tumors: a critical mediator of metastasis. Life Sci 249:117534","journal-title":"Life Sci"},{"key":"773_CR151","first-page":"46","volume":"3","author":"D Mukherjee","year":"2013","unstructured":"Mukherjee D, Zhao J (2013) The role of chemokine receptor CXCR4 in breast cancer metastasis. Am J Cancer Res 3:46\u201357","journal-title":"Am J Cancer Res"},{"key":"773_CR152","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.ygyno.2016.02.026","volume":"141","author":"A Munkarah","year":"2016","unstructured":"Munkarah A, Mert I, Chhina J, Hamid S, Poisson L, Hensley-Alford S, Giri S, Rattan R (2016) Targeting of free fatty acid receptor 1 in EOC: A novel strategy to restrict the adipocyte-EOC dependence. Gynecol Oncol 141:72\u201379","journal-title":"Gynecol Oncol"},{"key":"773_CR153","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1017\/S1462399407000476","volume":"9","author":"M Murph","year":"2007","unstructured":"Murph M, Mills GB (2007) Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression. Expert Rev Mol Med 9:1\u201318","journal-title":"Expert Rev Mol Med"},{"key":"773_CR154","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1084\/jem.20181494","volume":"216","author":"A Nakai","year":"2019","unstructured":"Nakai A, Fujimoto J, Miyata H, Stumm R, Narazaki M, Schulz S, Baba Y, Kumanogoh A, Suzuki K (2019) The COMMD3\/8 complex determines GRK6 specificity for chemoattractant receptors. J Exp Med 216:1630\u20131647","journal-title":"J Exp Med"},{"key":"773_CR155","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI200113640","volume":"108","author":"C Nataraj","year":"2001","unstructured":"Nataraj C, Thomas DW, Tilley SL, Nguyen MT, Mannon R, Koller BH, Coffman TM (2001) Receptors for prostaglandin E(2) that regulate cellular immune responses in the mouse. J Clin Invest 108:1229\u20131235","journal-title":"J Clin Invest"},{"key":"773_CR156","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.3390\/pharmaceutics14061303","volume":"14","author":"C Navarro","year":"2022","unstructured":"Navarro C, Ortega A, Santeliz R, Garrido B, Chacin M, Galban N, Vera I, De Sanctis JB, Bermudez V (2022) Metabolic reprogramming in cancer cells: emerging molecular mechanisms and novel therapeutic approaches. Pharmaceutics 14:1303","journal-title":"Pharmaceutics"},{"key":"773_CR157","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/s13578-020-00497-x","volume":"10","author":"HT Nguyen","year":"2020","unstructured":"Nguyen HT, Reyes-Alcaraz A, Yong HJ, Nguyen LP, Park H-K, Inoue A, Lee CS, Seong JY, Hwang J-I (2020) CXCR7: a \u03b2-arrestin-biased receptor that potentiates cell migration and recruits \u03b2-arrestin2 exclusively through g\u03b2\u03b3 subunits and GRK2. Cell Biosci 10:134","journal-title":"Cell Biosci"},{"key":"773_CR158","doi-asserted-by":"publisher","first-page":"213","DOI":"10.2147\/vhrm.2006.2.3.213","volume":"2","author":"N Nishida","year":"2006","unstructured":"Nishida N, Yano H, Nishida T, Kamura T, Kojiro M (2006) Angiogenesis in cancer. Vasc Health Risk Manag 2:213\u2013219","journal-title":"Vasc Health Risk Manag"},{"key":"773_CR159","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.ceb.2014.01.005","volume":"27","author":"M O\u2019Hayre","year":"2014","unstructured":"O\u2019Hayre M, Degese MS, Gutkind JS (2014) Novel insights into G protein and G protein-coupled receptor signaling in cancer. Curr Opin Cell Biol 27:126\u2013135","journal-title":"Curr Opin Cell Biol"},{"key":"773_CR160","doi-asserted-by":"crossref","unstructured":"Olejarz W, Kubiak-Tomaszewska G, Chrzanowska A, Lorenc T (2020) Exosomes in angiogenesis and anti-angiogenic therapy in cancers. Int J Mol Sci 21","DOI":"10.3390\/ijms21165840"},{"key":"773_CR161","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.715877","volume":"12","author":"C Oliveira de Souza","year":"2021","unstructured":"Oliveira de Souza C, Sun X, Oh D (2021) Metabolic functions of G protein-coupled receptors and beta-Arrestin-mediated signaling pathways in the pathophysiology of type 2 diabetes and obesity. Front Endocrinol (Lausanne) 12:715877","journal-title":"Front Endocrinol (Lausanne)"},{"key":"773_CR162","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/sj.bjc.6605588","volume":"102","author":"N Panupinthu","year":"2010","unstructured":"Panupinthu N, Lee HY, Mills GB (2010) Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression. Br J Cancer 102:941\u2013946","journal-title":"Br J Cancer"},{"key":"773_CR163","doi-asserted-by":"publisher","first-page":"5521","DOI":"10.3390\/ijms26072934","volume":"26","author":"R Patnaik","year":"2025","unstructured":"Patnaik R, Varghese RL, Banerjee Y (2025) Selective modulation of PAR-2-driven inflammatory pathways by Oleocanthal: attenuation of TNF-alpha and calcium dysregulation in colorectal Cancer models. Int J Mol Sci 26:5521","journal-title":"Int J Mol Sci"},{"key":"773_CR164","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.molcel.2013.02.024","volume":"50","author":"C Pelzel","year":"2013","unstructured":"Pelzel C, Begitt A, Wenta N, Vinkemeier U (2013) Evidence against a role for \u03b2-Arrestin1 in STAT1 Dephosphorylation and the inhibition of interferon-\u03b3 signaling. Mol Cell 50:149\u2013156","journal-title":"Mol Cell"},{"key":"773_CR165","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1038\/nrm908","volume":"3","author":"KL Pierce","year":"2002","unstructured":"Pierce KL, Premont RT, Lefkowitz RJ (2002) Seven-transmembrane receptors. Nat Rev Mol Cell Biol 3:639\u2013650","journal-title":"Nat Rev Mol Cell Biol"},{"key":"773_CR166","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1158\/0008-5472.CAN-14-0681","volume":"75","author":"S Pillai","year":"2015","unstructured":"Pillai S, Trevino J, Rawal B, Singh S, Kovacs M, Li X, Schell M, Haura E, Bepler G, Chellappan S (2015) Beta-arrestin-1 mediates nicotine-induced metastasis through E2F1 target genes that modulate epithelial-mesenchymal transition. Cancer Res 75:1009\u20131020","journal-title":"Cancer Res"},{"key":"773_CR167","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031827","volume":"7","author":"C Pourreyron","year":"2012","unstructured":"Pourreyron C, Reilly L, Proby C, Panteleyev A, Fleming C, McLean K, South AP, Foerster J (2012) Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical Wnt signalling is repressed. PLoS One 7:e31827","journal-title":"PLoS One"},{"key":"773_CR168","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1476-5381.2011.01810.x","volume":"166","author":"DR Poyner","year":"2012","unstructured":"Poyner DR, Hay DL (2012) Secretin family (class B) G protein-coupled receptors\u2014from molecular to clinical perspectives. Br J Pharmacol 166:1\u20133","journal-title":"Br J Pharmacol"},{"key":"773_CR169","doi-asserted-by":"publisher","DOI":"10.1016\/j.mbm.2024.100064","volume":"2","author":"L Pratiwi","year":"2024","unstructured":"Pratiwi L, Elisa E, Sutanto H (2024) Probing the protrusions: lamellipodia and filopodia in cancer invasion and beyond. Mechanobiol Med 2:100064","journal-title":"Mechanobiol Med"},{"key":"773_CR170","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/s41392-025-02241-8","volume":"10","author":"T Pu","year":"2025","unstructured":"Pu T, Sun J, Ren G, Li H (2025) Neuro-immune crosstalk in cancer: mechanisms and therapeutic implications. Signal Transduct Target Ther 10:176","journal-title":"Signal Transduct Target Ther"},{"key":"773_CR171","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.tem.2020.11.008","volume":"32","author":"SP Pydi","year":"2021","unstructured":"Pydi SP, Barella LF, Meister J, Wess J (2021) Key metabolic functions of beta-Arrestins: studies with novel mouse models. Trends Endocrinol Metab 32:118\u2013129","journal-title":"Trends Endocrinol Metab"},{"key":"773_CR172","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1186\/s12944-024-02196-9","volume":"23","author":"Y Qi","year":"2024","unstructured":"Qi Y, Wang Y, Yuan J, Xu Y, Pan H (2024) Unveiling the therapeutic promise: exploring lysophosphatidic acid (LPA) signaling in malignant bone tumors for novel cancer treatments. Lipids Health Dis 23:204","journal-title":"Lipids Health Dis"},{"key":"773_CR173","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3389\/fonc.2019.01370","volume":"9","author":"S Quintero-Fabian","year":"2019","unstructured":"Quintero-Fabian S, Arreola R, Becerril-Villanueva E, Torres-Romero JC, Arana-Argaez V, Lara-Riegos J, Ramirez-Camacho MA, Alvarez-Sanchez ME (2019) Role of matrix Metalloproteinases in angiogenesis and cancer. Front Oncol 9:1370","journal-title":"Front Oncol"},{"key":"773_CR174","doi-asserted-by":"publisher","first-page":"5699","DOI":"10.4049\/jimmunol.180.8.5699","volume":"180","author":"SK Raghuwanshi","year":"2008","unstructured":"Raghuwanshi SK, Nasser MW, Chen X, Strieter RM, Richardson RM (2008) Depletion of beta-arrestin-2 promotes tumor growth and angiogenesis in a murine model of lung cancer. J Immunol 180:5699\u20135706","journal-title":"J Immunol"},{"key":"773_CR175","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1084\/jem.20170277","volume":"216","author":"M Rapp","year":"2019","unstructured":"Rapp M, Wintergerst MWM, Kunz WG, Vetter VK, Knott MML, Lisowski D, Haubner S, Moder S, Thaler R, Eiber S, Meyer B, Rohrle N, Piseddu I, Grassmann S, Layritz P, Kuhnemuth B, Stutte S, Bourquin C, von Andrian UH, Endres S, Anz D (2019) CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes. J Exp Med 216:1170\u20131181","journal-title":"J Exp Med"},{"key":"773_CR176","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41388-021-02069-w","volume":"41","author":"SAK Rasheed","year":"2022","unstructured":"Rasheed SAK, Subramanyan LV, Lim WK, Udayappan UK, Wang M, Casey PJ (2022) The emerging roles of Galpha12\/13 proteins on the hallmarks of cancer in solid tumors. Oncogene 41:147\u2013158","journal-title":"Oncogene"},{"key":"773_CR177","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ccell.2017.11.007","volume":"33","author":"BW Renz","year":"2018","unstructured":"Renz BW, Takahashi R, Tanaka T, Macchini M, Hayakawa Y, Dantes Z, Maurer HC, Chen X, Jiang Z, Westphalen CB, Ilmer M, Valenti G, Mohanta SK, Habenicht AJR, Middelhoff M, Chu T, Nagar K, Tailor Y, Casadei R, Di Marco M, Kleespies A, Friedman RA, Remotti H, Reichert M, Worthley DL, Neumann J, Werner J, Iuga AC, Olive KP, Wang TC (2018) beta2 adrenergic-Neurotrophin feedforward loop promotes pancreatic Cancer. Cancer Cell 33:75\u201390 e7","journal-title":"Cancer Cell"},{"key":"773_CR178","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115804","volume":"168","author":"F Ricci","year":"2023","unstructured":"Ricci F, Di Credico A, Gaggi G, Iannetti G, Ghinassi B, Gallina S, Olshansky B, Di Baldassarre A (2023) Metoprolol disrupts inflammatory response of human cardiomyocytes via \u03b2-arrestin2 biased agonism and NF-\u03baB signaling modulation. Biomed Pharmacother 168:115804","journal-title":"Biomed Pharmacother"},{"key":"773_CR179","doi-asserted-by":"publisher","first-page":"e178109","DOI":"10.1172\/JCI178109","volume":"134","author":"HA Rockman","year":"2024","unstructured":"Rockman HA, Lefkowitz RJ (2024) G protein-coupled receptors: from radioligand binding to cellular signaling. J Clin Invest 134:e178109","journal-title":"J Clin Invest"},{"key":"773_CR180","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1007\/s12307-011-0088-1","volume":"4","author":"J Rolin","year":"2011","unstructured":"Rolin J, Maghazachi AA (2011) Effects of lysophospholipids on tumor microenvironment. Cancer Microenviron 4:393\u2013403","journal-title":"Cancer Microenviron"},{"key":"773_CR181","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1172\/JCI9775","volume":"107","author":"P Romagnani","year":"2001","unstructured":"Romagnani P, Annunziato F, Lasagni L, Lazzeri E, Beltrame C, Francalanci M, Uguccioni M, Galli G, Cosmi L, Maurenzig L, Baggiolini M, Maggi E, Romagnani S, Serio M (2001) Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity. J Clin Invest 107:53\u201363","journal-title":"J Clin Invest"},{"key":"773_CR182","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s13046-016-0401-4","volume":"35","author":"L Rosano","year":"2016","unstructured":"Rosano L, Bagnato A (2016) Beta-arrestin1 at the cross-road of endothelin-1 signaling in cancer. J Exp Clin Cancer Res 35:121","journal-title":"J Exp Clin Cancer Res"},{"key":"773_CR183","volume-title":"International review of cell and molecular biology","author":"L Rosan\u00f2","year":"2019","unstructured":"Rosan\u00f2 L, Bagnato A (2019) Chapter 4: new insights into the regulation of the actin cytoskeleton dynamics by GPCR\/\u03b2-arrestin in cancer invasion and metastasis. In: Galluzzi L (ed) International review of cell and molecular biology. Academic"},{"key":"773_CR184","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s40364-025-00778-y","volume":"13","author":"A Rueda","year":"2025","unstructured":"Rueda A, Serna N, Mangues R, Villaverde A, Unzueta U (2025) Targeting the chemokine receptor CXCR4 for cancer therapies. Biomark Res 13:68","journal-title":"Biomark Res"},{"issue":"Suppl 2","key":"773_CR185","doi-asserted-by":"publisher","first-page":"S36","DOI":"10.1016\/S0049-3848(10)70010-4","volume":"125","author":"W Ruf","year":"2010","unstructured":"Ruf W, Yokota N, Schaffner F (2010) Tissue factor in cancer progression and angiogenesis. Thromb Res 125(Suppl 2):S36\u2013S38","journal-title":"Thromb Res"},{"key":"773_CR186","doi-asserted-by":"publisher","first-page":"1104521","DOI":"10.3389\/fonc.2023.1104521","volume":"13","author":"JW Ryu","year":"2023","unstructured":"Ryu JW, Shin HY, Kim HS, Han GH, Kim JW, Lee HN, Cho H, Chung JY, Kim JH (2023) Prognostic value of beta-Arrestins in combination with glucocorticoid receptor in epithelial ovarian cancer. Front Oncol 13:1104521","journal-title":"Front Oncol"},{"key":"773_CR187","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s43042-024-00485-7","volume":"25","author":"M Saddam","year":"2024","unstructured":"Saddam M, Paul SK, Habib MA, Fahim MA, Mimi A, Islam S, Paul B, Helal MMU (2024) Emerging biomarkers and potential therapeutics of the BCL-2 protein family: the apoptotic and anti-apoptotic context. Egypt J Med Hum Genet 25:12","journal-title":"Egypt J Med Hum Genet"},{"key":"773_CR188","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3389\/fimmu.2019.00147","volume":"10","author":"N Salazar","year":"2019","unstructured":"Salazar N, Zabel BA (2019) Support of tumor endothelial cells by chemokine receptors. Front Immunol 10:147","journal-title":"Front Immunol"},{"key":"773_CR189","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188499","volume":"1875","author":"A Salem","year":"2021","unstructured":"Salem A, Alotaibi M, Mroueh R, Basheer HA, Afarinkia K (2021) CCR7 as a therapeutic target in Cancer. Biochim Biophys Acta Rev Cancer 1875:188499","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"773_CR190","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpet.2025.103573","volume":"392","author":"C Salmeron","year":"2025","unstructured":"Salmeron C, Tomas Bort E, Sriram K, Javadi-Paydar M, Smitham JE, Pham K, Grose RP, McCormick PJ, DiNardo A, Weitz J, Tiriac H, Lowy AM, Insel PA (2025) Histamine H1 receptor: A potential therapeutic target for pancreatic ductal adenocarcinoma. J Pharmacol Exp Ther 392:103573","journal-title":"J Pharmacol Exp Ther"},{"key":"773_CR191","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.18632\/oncotarget.1426","volume":"4","author":"PJ Sarvaiya","year":"2013","unstructured":"Sarvaiya PJ, Guo D, Ulasov I, Gabikian P, Lesniak MS (2013) Chemokines in tumor progression and metastasis. Oncotarget 4:2171\u20132185","journal-title":"Oncotarget"},{"key":"773_CR192","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.ygcen.2004.12.018","volume":"142","author":"HB Schioth","year":"2005","unstructured":"Schioth HB, Fredriksson R (2005) The GRAFS classification system of G-protein coupled receptors in comparative perspective. Gen Comp Endocrinol 142:94\u2013101","journal-title":"Gen Comp Endocrinol"},{"key":"773_CR193","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1084\/jem.20111739","volume":"209","author":"M Schiraldi","year":"2012","unstructured":"Schiraldi M, Raucci A, Munoz LM, Livoti E, Celona B, Venereau E, Apuzzo T, De Marchis F, Pedotti M, Bachi A, Thelen M, Varani L, Mellado M, Proudfoot A, Bianchi ME, Uguccioni M (2012) HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4. J Exp Med 209:551\u2013563","journal-title":"J Exp Med"},{"key":"773_CR194","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.702726","volume":"12","author":"EN Scott","year":"2021","unstructured":"Scott EN, Gocher AM, Workman CJ, Vignali DAA (2021) Regulatory T cells: barriers of immune infiltration into the tumor microenvironment. Front Immunol 12:702726","journal-title":"Front Immunol"},{"key":"773_CR195","doi-asserted-by":"publisher","first-page":"11977","DOI":"10.3748\/wjg.v20.i34.11977","volume":"20","author":"S Sedda","year":"2014","unstructured":"Sedda S, Marafini I, Caruso R, Pallone F, Monteleone G (2014) Proteinase activated-receptors-associated signaling in the control of gastric cancer. World J Gastroenterol 20:11977\u201311984","journal-title":"World J Gastroenterol"},{"key":"773_CR196","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.908156","volume":"12","author":"K Shah","year":"2022","unstructured":"Shah K, Mallik SB, Gupta P, Iyer A (2022) Targeting tumour-associated fibroblasts in cancers. Front Oncol 12:908156","journal-title":"Front Oncol"},{"key":"773_CR197","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/gene.2015.37","volume":"16","author":"D Sharma","year":"2015","unstructured":"Sharma D, Parameswaran N (2015) Multifaceted role of beta-arrestins in inflammation and disease. Genes Immun 16:499\u2013513","journal-title":"Genes Immun"},{"key":"773_CR198","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1038\/onc.2011.238","volume":"31","author":"SK Shenoy","year":"2012","unstructured":"Shenoy SK, Han S, Zhao YL, Hara MR, Oliver T, Cao Y, Dewhirst MW (2012) Beta-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression. Oncogene 31:282\u2013292","journal-title":"Oncogene"},{"key":"773_CR199","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/ni1489","volume":"8","author":"Y Shi","year":"2007","unstructured":"Shi Y, Feng Y, Kang J, Liu C, Li Z, Li D, Cao W, Qiu J, Guo Z, Bi E, Zang L, Lu C, Zhang JZ, Pei G (2007) Critical regulation of CD4+ T cell survival and autoimmunity by beta-arrestin 1. Nat Immunol 8:817\u2013824","journal-title":"Nat Immunol"},{"key":"773_CR200","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/bs.acr.2020.01.001","volume":"145","author":"AK Shukla","year":"2020","unstructured":"Shukla AK, Dwivedi-Agnihotri H (2020) Structure and function of beta-arrestins, their emerging role in breast cancer, and potential opportunities for therapeutic manipulation. Adv Cancer Res 145:139\u2013156","journal-title":"Adv Cancer Res"},{"key":"773_CR201","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1016\/j.tibs.2011.06.003","volume":"36","author":"AK Shukla","year":"2011","unstructured":"Shukla AK, Xiao K, Lefkowitz RJ (2011) Emerging paradigms of beta-arrestin-dependent seven transmembrane receptor signaling. Trends Biochem Sci 36:457\u2013469","journal-title":"Trends Biochem Sci"},{"key":"773_CR202","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1038\/labinvest.3700181","volume":"84","author":"S Singh","year":"2004","unstructured":"Singh S, Singh UP, Grizzle WE, Lillard JW Jr (2004) CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Investig 84:1666\u20131676","journal-title":"Lab Investig"},{"key":"773_CR203","first-page":"1569","volume":"3","author":"R Singh","year":"2011","unstructured":"Singh R, Lillard JW Jr, Singh S (2011) Chemokines: key players in cancer progression and metastasis. Front Biosci (Schol Ed) 3:1569\u20131582","journal-title":"Front Biosci (Schol Ed)"},{"key":"773_CR204","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1016\/B978-0-12-394440-5.00015-2","volume":"118","author":"PM Sobolesky","year":"2013","unstructured":"Sobolesky PM, Moussa O (2013a) The role of beta-arrestins in cancer. Prog Mol Biol Transl Sci 118:395\u2013411","journal-title":"Prog Mol Biol Transl Sci"},{"key":"773_CR205","volume-title":"Progress in molecular biology and translational science","author":"PM Sobolesky","year":"2013","unstructured":"Sobolesky PM, Moussa O (2013b) Chapter 15: The role of \u03b2-Arrestins in Cancer. In: Luttrell LM (ed) Progress in molecular biology and translational science. Academic"},{"key":"773_CR206","first-page":"631","volume":"41","author":"Q Song","year":"2018","unstructured":"Song Q, Ji Q, Li Q (2018) The role and mechanism of beta-arrestins in cancer invasion and metastasis (review). Int J Mol Med 41:631\u2013639","journal-title":"Int J Mol Med"},{"key":"773_CR207","first-page":"31","volume":"24","author":"M Strazza","year":"2017","unstructured":"Strazza M, Mor A (2017) Consider the chemokines: a review of the interplay between chemokines and T cell subset function. Discov Med 24:31\u201339","journal-title":"Discov Med"},{"key":"773_CR208","doi-asserted-by":"publisher","first-page":"5396","DOI":"10.4049\/jimmunol.175.8.5396","volume":"175","author":"Y Su","year":"2005","unstructured":"Su Y, Raghuwanshi SK, Yu Y, Nanney LB, Richardson RM, Richmond A (2005) Altered CXCR2 signaling in beta-arrestin-2-deficient mouse models. J Immunol 175:5396\u20135402","journal-title":"J Immunol"},{"key":"773_CR209","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1007\/s00262-008-0494-5","volume":"57","author":"Y Su","year":"2008","unstructured":"Su Y, Huang X, Raskovalova T, Zacharia L, Lokshin A, Jackson E, Gorelik E (2008) Cooperation of adenosine and prostaglandin E2 (PGE2) in amplification of cAMP-PKA signaling and immunosuppression. Cancer Immunol Immunother 57:1611\u20131623","journal-title":"Cancer Immunol Immunother"},{"key":"773_CR210","doi-asserted-by":"publisher","first-page":"5734","DOI":"10.1038\/onc.2017.179","volume":"36","author":"N Suleymanova","year":"2017","unstructured":"Suleymanova N, Crudden C, Shibano T, Worrall C, Oprea I, Tica A, Calin GA, Girnita A, Girnita L (2017) Functional antagonism of beta-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes. Oncogene 36:5734\u20135744","journal-title":"Oncogene"},{"key":"773_CR211","doi-asserted-by":"publisher","first-page":"35808","DOI":"10.1038\/srep35808","volume":"6","author":"JJ Sun","year":"2016","unstructured":"Sun JJ, Yang HT, Niu GJ, Feng XW, Lan JF, Zhao XF, Wang JX (2016a) \u03b2-Arrestin 1\u2019s Interaction with TC45 Attenuates Stat signaling by dephosphorylating Stat to inhibit antimicrobial peptide expression. Sci Rep 6:35808","journal-title":"Sci Rep"},{"key":"773_CR212","doi-asserted-by":"publisher","first-page":"35609","DOI":"10.1038\/srep35609","volume":"6","author":"W-Y Sun","year":"2016","unstructured":"Sun W-Y, Shan-Shan H, Jing-Jing W, Huang Q, Ma Y, Wang Q-T, Chen J-Y, Wei W (2016b) Down-regulation of \u03b2-arrestin2 promotes tumour invasion and indicates poor prognosis of hepatocellular carcinoma. Sci Rep 6:35609","journal-title":"Sci Rep"},{"key":"773_CR213","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1038\/s41401-018-0049-z","volume":"39","author":"WY Sun","year":"2018","unstructured":"Sun WY, Wu JJ, Peng WT, Sun JC, Wei W (2018) The role of G protein-coupled receptor kinases in the pathology of malignant tumors. Acta Pharmacol Sin 39:1699\u20131705","journal-title":"Acta Pharmacol Sin"},{"key":"773_CR214","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1002\/cam4.1339","volume":"7","author":"K Suvarna","year":"2018","unstructured":"Suvarna K, Honda K, Kondoh Y, Osada H, Watanabe N (2018) Identification of a small-molecule ligand of beta-arrestin1 as an inhibitor of stromal fibroblast cell migration accelerated by cancer cells. Cancer Med 7:883\u2013893","journal-title":"Cancer Med"},{"key":"773_CR215","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.957981","volume":"14","author":"T Szenasi","year":"2023","unstructured":"Szenasi T, Turu G, Hunyady L (2023) Interactions between beta-arrestin proteins and the cytoskeletal system, and their relevance to neurodegenerative disorders. Front Endocrinol (Lausanne) 14:957981","journal-title":"Front Endocrinol (Lausanne)"},{"key":"773_CR216","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2025.152268","volume":"127","author":"M Tamura","year":"2025","unstructured":"Tamura M, Takai M, Yamamoto M, Yashiro N, Taniguchi A, Kusumoto Y, Nagano S, Shimomura N, Tsujiuchi T (2025) Lysophosphatidic acid (LPA) receptor signaling enhances malignant potential in highly migratory lung cancer cells under hypoxic conditions. Acta Histochem 127:152268","journal-title":"Acta Histochem"},{"key":"773_CR217","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1111\/j.1349-7006.2005.00059.x","volume":"96","author":"T Tanaka","year":"2005","unstructured":"Tanaka T, Bai Z, Srinoulprasert Y, Yang BG, Hayasaka H, Miyasaka M (2005) Chemokines in tumor progression and metastasis. Cancer Sci 96:317\u2013322","journal-title":"Cancer Sci"},{"key":"773_CR218","doi-asserted-by":"publisher","first-page":"14993","DOI":"10.3390\/ijms241914993","volume":"24","author":"AC Tirado-Garibay","year":"2023","unstructured":"Tirado-Garibay AC, Falcon-Ruiz EA, Ochoa-Zarzosa A, Lopez-Meza JE (2023) GPER: an estrogen receptor key in metastasis and Tumoral microenvironments. Int J Mol Sci 24:14993","journal-title":"Int J Mol Sci"},{"key":"773_CR219","doi-asserted-by":"publisher","first-page":"609","DOI":"10.3389\/fendo.2019.00609","volume":"10","author":"P Tocci","year":"2019","unstructured":"Tocci P, Rosano L, Bagnato A (2019) Targeting Endothelin-1 receptor\/beta-Arrestin-1 Axis in ovarian Cancer: from basic research to a therapeutic approach. Front Endocrinol (Lausanne) 10:609","journal-title":"Front Endocrinol (Lausanne)"},{"key":"773_CR220","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1186\/s13046-021-01827-8","volume":"40","author":"P Tocci","year":"2021","unstructured":"Tocci P, Blandino G, Bagnato A (2021) YAP and endothelin-1 signaling: an emerging alliance in cancer. J Exp Clin Cancer Res 40:27","journal-title":"J Exp Clin Cancer Res"},{"key":"773_CR221","doi-asserted-by":"publisher","first-page":"753","DOI":"10.14740\/jocmr4387","volume":"12","author":"VD Upadhyaya","year":"2020","unstructured":"Upadhyaya VD, Douedi S, Garcia B, Gonzalez J, Udongwo N, Wei J, Nai Q, Asif A, Sen S (2020) Mechanism and effect of Beta-blockers on pancreatic adenocarcinoma: a literature review. J Clin Med Res 12:753\u2013757","journal-title":"J Clin Med Res"},{"key":"773_CR222","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.jpha.2020.01.001","volume":"10","author":"S Usman","year":"2020","unstructured":"Usman S, Khawer M, Rafique S, Naz Z, Saleem K (2020) The current status of anti-GPCR drugs against different cancers. J Pharm Anal 10:517\u2013521","journal-title":"J Pharm Anal"},{"key":"773_CR223","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.molcel.2012.10.018","volume":"49","author":"JP Vaque","year":"2013","unstructured":"Vaque JP, Dorsam RT, Feng X, Iglesias-Bartolome R, Forsthoefel DJ, Chen Q, Debant A, Seeger MA, Ksander BR, Teramoto H, Gutkind JS (2013) A genome-wide RNAi screen reveals a trio-regulated rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors. Mol Cell 49:94\u2013108","journal-title":"Mol Cell"},{"key":"773_CR224","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1007\/s10456-014-9420-y","volume":"17","author":"NS Vasudev","year":"2014","unstructured":"Vasudev NS, Reynolds AR (2014) Anti-angiogenic therapy for cancer: current progress, unresolved questions and future directions. Angiogenesis 17:471\u2013494","journal-title":"Angiogenesis"},{"key":"773_CR225","doi-asserted-by":"publisher","first-page":"7219","DOI":"10.1158\/0008-5472.CAN-08-0419","volume":"68","author":"HH Versteeg","year":"2008","unstructured":"Versteeg HH, Schaffner F, Kerver M, Ellies LG, Andrade-Gordon P, Mueller BM, Ruf W (2008) Protease-activated receptor (PAR) 2, but not PAR1, signaling promotes the development of mammary adenocarcinoma in polyoma middle T mice. Cancer Res 68:7219\u20137227","journal-title":"Cancer Res"},{"key":"773_CR226","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.ccr.2006.02.023","volume":"9","author":"B Visentin","year":"2006","unstructured":"Visentin B, Vekich JA, Sibbald BJ, Cavalli AL, Moreno KM, Matteo RG, Garland WA, Lu Y, Yu S, Hall HS, Kundra V, Mills GB, Sabbadini RA (2006) Validation of an anti-sphingosine-1-phosphate antibody as a potential therapeutic in reducing growth, invasion, and angiogenesis in multiple tumor lineages. Cancer Cell 9:225\u2013238","journal-title":"Cancer Cell"},{"key":"773_CR227","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1189\/jlb.0606373","volume":"80","author":"A Vroon","year":"2006","unstructured":"Vroon A, Heijnen CJ, Kavelaars A (2006) GRKs and arrestins: regulators of migration and inflammation. J Leukoc Biol 80:1214\u20131221","journal-title":"J Leukoc Biol"},{"key":"773_CR228","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1016\/j.phrs.2011.01.002","volume":"63","author":"R Wang","year":"2011","unstructured":"Wang R, Dashwood RH (2011) Endothelins and their receptors in cancer: identification of therapeutic targets. Pharmacol Res 63:519\u2013524","journal-title":"Pharmacol Res"},{"key":"773_CR229","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.7314\/APJCP.2012.13.11.5671","volume":"13","author":"LG Wang","year":"2012","unstructured":"Wang LG, Su BH, Du JJ (2012) Expression of beta-arrestin 1 in gastric cardiac adenocarcinoma and its relation with progression. Asian Pac J Cancer Prev 13:5671\u20135675","journal-title":"Asian Pac J Cancer Prev"},{"key":"773_CR230","doi-asserted-by":"publisher","first-page":"26999","DOI":"10.1038\/srep26999","volume":"6","author":"C Wang","year":"2016","unstructured":"Wang C, Zeng X, Zhou Z, Zhao J, Pei G (2016) \u03b2-arrestin-1 contributes to brown fat function and directly interacts with PPAR\u03b1 and PPAR\u03b3. Sci Rep 6:26999","journal-title":"Sci Rep"},{"key":"773_CR231","doi-asserted-by":"publisher","first-page":"1022688","DOI":"10.3389\/fonc.2022.1022688","volume":"12","author":"X Wang","year":"2022","unstructured":"Wang X, Zhang Y, Wang S, Ni H, Zhao P, Chen G, Xu B, Yuan L (2022) The role of CXCR3 and its ligands in cancer. Front Oncol 12:1022688","journal-title":"Front Oncol"},{"issue":"2281\u201397","key":"773_CR232","volume":"36","author":"X Wei","year":"2024","unstructured":"Wei X, Wu D, Li J, Wu M, Li Q, Che Z, Cheng X, Cheng Q, Yin F, Zhang H, Wang X, Abtahi S, Zuo L, Hang L, Ma L, Kuo WT, Liu X, Turner JR, Wang H, Xiao J, Wang F (2024) Myeloid beta-arrestin 2 depletion attenuates metabolic dysfunction-associated steatohepatitis via the metabolic reprogramming of macrophages. Cell Metab 36(2281\u201397):e7","journal-title":"Cell Metab"},{"key":"773_CR233","doi-asserted-by":"crossref","unstructured":"Wess J (2022) The two beta-Arrestins regulate distinct metabolic processes: studies with novel mutant mouse models. Int J Mol Sci 23","DOI":"10.3390\/ijms23010495"},{"key":"773_CR234","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1152\/physrev.00003.2005","volume":"85","author":"N Wettschureck","year":"2005","unstructured":"Wettschureck N, Offermanns S (2005) Mammalian G proteins and their cell type specific functions. Physiol Rev 85:1159\u20131204","journal-title":"Physiol Rev"},{"key":"773_CR235","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.molmed.2010.11.004","volume":"17","author":"EJ Whalen","year":"2011","unstructured":"Whalen EJ, Rajagopal S, Lefkowitz RJ (2011) Therapeutic potential of beta-arrestin- and G protein-biased agonists. Trends Mol Med 17:126\u2013139","journal-title":"Trends Mol Med"},{"key":"773_CR236","doi-asserted-by":"publisher","first-page":"212","DOI":"10.3389\/fimmu.2013.00212","volume":"4","author":"TL Whiteside","year":"2013","unstructured":"Whiteside TL, Jackson EK (2013) Adenosine and prostaglandin e2 production by human inducible regulatory T cells in health and disease. Front Immunol 4:212","journal-title":"Front Immunol"},{"key":"773_CR237","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ceb.2013.10.008","volume":"27","author":"JW Wisler","year":"2014","unstructured":"Wisler JW, Xiao K, Thomsen ARB, Lefkowitz RJ (2014) Recent developments in biased agonism. Curr Opin Cell Biol 27:18\u201324","journal-title":"Curr Opin Cell Biol"},{"key":"773_CR238","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1007\/s10555-015-9599-4","volume":"34","author":"MZ Wojtukiewicz","year":"2015","unstructured":"Wojtukiewicz MZ, Hempel D, Sierko E, Tucker SC, Honn KV (2015) Protease-activated receptors (PARs)--biology and role in cancer invasion and metastasis. Cancer Metastasis Rev 34:775\u2013796","journal-title":"Cancer Metastasis Rev"},{"key":"773_CR239","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079481","volume":"8","author":"SC Wong","year":"2013","unstructured":"Wong SC, He CW, Chan CM, Chan AK, Wong HT, Cheung MT, Luk LL, Au TC, Chiu MK, Ma BB, Chan AT (2013) Clinical significance of frizzled homolog 3 protein in colorectal cancer patients. PLoS One 8:e79481","journal-title":"PLoS One"},{"key":"773_CR240","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.7314\/APJCP.2014.15.2.1041","volume":"15","author":"JX Wu","year":"2014","unstructured":"Wu JX, Shan FX, Zheng JN, Pei DS (2014) \u03b2-arrestin promotes c-Jun N-terminal kinase mediated apoptosis via a GABA(B)R\u00b7\u03b2-arrestin\u00b7JNK signaling module. Asian Pac J Cancer Prev 15:1041\u20131046","journal-title":"Asian Pac J Cancer Prev"},{"key":"773_CR241","doi-asserted-by":"publisher","first-page":"11062","DOI":"10.1074\/jbc.REV119.005601","volume":"294","author":"V Wu","year":"2019","unstructured":"Wu V, Yeerna H, Nohata N, Chiou J, Harismendy O, Raimondi F, Inoue A, Russell RB, Tamayo P, Gutkind JS (2019) Illuminating the Onco-GPCRome: novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy. J Biol Chem 294:11062\u201311086","journal-title":"J Biol Chem"},{"key":"773_CR242","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1038\/s41590-023-01529-7","volume":"24","author":"VH Wu","year":"2023","unstructured":"Wu VH, Yung BS, Faraji F, Saddawi-Konefka R, Wang Z, Wenzel AT, Song MJ, Pagadala MS, Clubb LM, Chiou J, Sinha S, Matic M, Raimondi F, Hoang TS, Berdeaux R, Vignali DAA, Iglesias-Bartolome R, Carter H, Ruppin E, Mesirov JP, Gutkind JS (2023) The GPCR-Galpha(s)-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure. Nat Immunol 24:1318\u20131330","journal-title":"Nat Immunol"},{"key":"773_CR243","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12964-024-01585-y","volume":"22","author":"Y Xia","year":"2024","unstructured":"Xia Y, Wang S, Sun Y, Wang W, Chang S, Zhang Z, Zhao C (2024) Frizzled class receptor 5 contributes to ovarian cancer chemoresistance through aldehyde dehydrogenase 1A1. Cell Commun Signal 22:194","journal-title":"Cell Commun Signal"},{"key":"773_CR244","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.cellsig.2017.09.013","volume":"41","author":"K Xiao","year":"2018","unstructured":"Xiao K, Sun J (2018) Elucidating structural and molecular mechanisms of beta-arrestin-biased agonism at GPCRs via MS-based proteomics. Cell Signal 41:56\u201364","journal-title":"Cell Signal"},{"key":"773_CR245","doi-asserted-by":"publisher","first-page":"12011","DOI":"10.1073\/pnas.0704849104","volume":"104","author":"K Xiao","year":"2007","unstructured":"Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK, Yates JR 3rd, Lefkowitz RJ (2007) Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci USA 104:12011\u201312016","journal-title":"Proc Natl Acad Sci USA"},{"key":"773_CR246","doi-asserted-by":"publisher","first-page":"15299","DOI":"10.1073\/pnas.1008461107","volume":"107","author":"K Xiao","year":"2010","unstructured":"Xiao K, Sun J, Kim J, Rajagopal S, Zhai B, Villen J, Haas W, Kovacs JJ, Shukla AK, Hara MR, Hernandez M, Lachmann A, Zhao S, Lin Y, Cheng Y, Mizuno K, Ma\u2019ayan A, Gygi SP, Lefkowitz RJ (2010) Global phosphorylation analysis of beta-arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR). Proc Natl Acad Sci USA 107:15299\u201315304","journal-title":"Proc Natl Acad Sci USA"},{"key":"773_CR247","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3390\/cancers10070227","volume":"10","author":"Y Xu","year":"2018","unstructured":"Xu Y (2018) Lysophospholipid signaling in the epithelial ovarian Cancer tumor microenvironment. Cancers (Basel) 10:227","journal-title":"Cancers (Basel)"},{"key":"773_CR248","doi-asserted-by":"publisher","first-page":"2229","DOI":"10.1111\/jgh.15115","volume":"35","author":"X Xu","year":"2020","unstructured":"Xu X, Lei Y, Zhou H, Guo Y, Liu H, Jiang J, Yang Y, Wu B (2020) Beta-Arrestin1 is involved in hepatocellular carcinoma metastasis via extracellular signal-regulated kinase-mediated epithelial-mesenchymal transition. J Gastroenterol Hepatol 35:2229\u20132240","journal-title":"J Gastroenterol Hepatol"},{"key":"773_CR249","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1038\/s41420-022-00818-8","volume":"8","author":"Y Xu","year":"2022","unstructured":"Xu Y, Wang J, Wang X, Zhou X, Tang J, Jie X, Yang X, Rao X, Xu Y, Xing B, Li Z, Wu G (2022) Targeting ADRB2 enhances sensitivity of non-small cell lung cancer to VEGFR2 tyrosine kinase inhibitors. Cell Death Discov 8:36","journal-title":"Cell Death Discov"},{"key":"773_CR250","doi-asserted-by":"publisher","first-page":"1449126","DOI":"10.3389\/fimmu.2024.1449126","volume":"15","author":"K Xu","year":"2024","unstructured":"Xu K, Wang L, Lin M, He G (2024) Update on protease-activated receptor 2 in inflammatory and autoimmune dermatological diseases. Front Immunol 15:1449126","journal-title":"Front Immunol"},{"key":"773_CR251","doi-asserted-by":"publisher","first-page":"e240369","DOI":"10.1530\/ETJ-24-0369","volume":"14","author":"S Xu","year":"2025","unstructured":"Xu S, Peng Y, Li X, Li H, Liu T, Li X, Du Y (2025) TSHR in thyroid cancer: bridging biological insights to targeted strategies. Eur Thyroid J 14:e240369","journal-title":"Eur Thyroid J"},{"key":"773_CR252","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.bbamcr.2006.07.001","volume":"1773","author":"H Yamaguchi","year":"2007","unstructured":"Yamaguchi H, Condeelis J (2007) Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 1773:642\u2013652","journal-title":"Biochim Biophys Acta"},{"key":"773_CR253","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2025.101098","volume":"96","author":"M Yamamoto","year":"2025","unstructured":"Yamamoto M, Takai M, Yashiro N, Tamura M, Kusumoto Y, Nagano S, Taniguchi A, Shimomura N, Tsujiuchi T (2025) Lysophosphatidic acid (LPA) receptor signaling modulates cellular functions of colon cancer cells under cobalt chloride-induced hypoxic conditions. Adv Biol Regul 96:101098","journal-title":"Adv Biol Regul"},{"key":"773_CR254","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108199","volume":"239","author":"I Yaman","year":"2022","unstructured":"Yaman I, Agac Cobanoglu D, Xie T, Ye Y, Amit M (2022) Advances in understanding cancer-associated neurogenesis and its implications on the neuroimmune axis in cancer. Pharmacol Ther 239:108199","journal-title":"Pharmacol Ther"},{"key":"773_CR255","doi-asserted-by":"publisher","first-page":"9717","DOI":"10.3748\/wjg.v21.i33.9717","volume":"21","author":"Y Yan","year":"2015","unstructured":"Yan Y, Wang LF, Wang RF (2015) Role of cancer-associated fibroblasts in invasion and metastasis of gastric cancer. World J Gastroenterol 21:9717\u20139726","journal-title":"World J Gastroenterol"},{"key":"773_CR256","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1158\/0008-5472.CAN-13-1268","volume":"74","author":"L Yang","year":"2014","unstructured":"Yang L, Friedland S, Corson N, Xu L (2014) GPR56 inhibits melanoma growth by internalizing and degrading its ligand TG2. Cancer Res 74:1022\u20131031","journal-title":"Cancer Res"},{"key":"773_CR257","doi-asserted-by":"publisher","first-page":"7369","DOI":"10.1038\/ncomms8369","volume":"6","author":"Y Yang","year":"2015","unstructured":"Yang Y, Guo Y, Tan S, Ke B, Tao J, Liu H, Jiang J, Chen J, Chen G, Wu B (2015) Beta-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling. Nat Commun 6:7369","journal-title":"Nat Commun"},{"key":"773_CR258","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.3389\/fimmu.2020.01371","volume":"11","author":"Y Yang","year":"2020","unstructured":"Yang Y, Li C, Liu T, Dai X, Bazhin AV (2020) Myeloid-derived suppressor cells in tumors: from mechanisms to antigen specificity and microenvironmental regulation. Front Immunol 11:1371","journal-title":"Front Immunol"},{"key":"773_CR259","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41392-020-00435-w","volume":"6","author":"D Yang","year":"2021","unstructured":"Yang D, Zhou Q, Labroska V, Qin S, Darbalaei S, Wu Y, Yuliantie E, Xie L, Tao H, Cheng J, Liu Q, Zhao S, Shui W, Jiang Y, Wang MW (2021) G protein-coupled receptors: structure- and function-based drug discovery. Signal Transduct Target Ther 6:7","journal-title":"Signal Transduct Target Ther"},{"key":"773_CR260","doi-asserted-by":"publisher","first-page":"2778","DOI":"10.1007\/s12094-024-03831-8","volume":"27","author":"Y Yang","year":"2025","unstructured":"Yang Y, Ma X, Li Y, Jin L, Zhou X (2025) The evolving tumor-associated adipose tissue microenvironment in breast cancer: from cancer initiation to metastatic outgrowth. Clin Transl Oncol 27:2778\u20132788","journal-title":"Clin Transl Oncol"},{"key":"773_CR261","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1080\/00365521.2017.1281435","volume":"52","author":"X Ye","year":"2017","unstructured":"Ye X, Liu S, Hu M, Song Y, Huang H, Zhong Y (2017) CCR5 expression in inflammatory bowel disease and its correlation with inflammatory cells and beta-arrestin2 expression. Scand J Gastroenterol 52:551\u2013557","journal-title":"Scand J Gastroenterol"},{"key":"773_CR262","doi-asserted-by":"publisher","first-page":"1375543","DOI":"10.3389\/fcell.2024.1375543","volume":"12","author":"J Yin","year":"2024","unstructured":"Yin J, Zhu W, Feng S, Yan P, Qin S (2024) The role of cancer-associated fibroblasts in the invasion and metastasis of colorectal cancer. Front Cell Dev Biol 12:1375543","journal-title":"Front Cell Dev Biol"},{"key":"773_CR263","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1093\/jnci\/djn378","volume":"100","author":"S Yu","year":"2008","unstructured":"Yu S, Murph MM, Lu Y, Liu S, Hall HS, Liu J, Stephens C, Fang X, Mills GB (2008) Lysophosphatidic acid receptors determine tumorigenicity and aggressiveness of ovarian cancer cells. J Natl Cancer Inst 100:1630\u20131642","journal-title":"J Natl Cancer Inst"},{"key":"773_CR264","doi-asserted-by":"publisher","first-page":"189","DOI":"10.7150\/ijbs.22896","volume":"14","author":"S Yu","year":"2018","unstructured":"Yu S, Sun L, Jiao Y, Lee LTO (2018) The role of G protein-coupled receptor kinases in Cancer. Int J Biol Sci 14:189\u2013203","journal-title":"Int J Biol Sci"},{"key":"773_CR265","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2123231119","volume":"119","author":"H Yu","year":"2022","unstructured":"Yu H, Wang M, Zhang T, Cao L, Li Z, Du Y, Hai Y, Gao X, Ji J, Wu J (2022) Dual roles of beta-arrestin 1 in mediating cell metabolism and proliferation in gastric cancer. Proc Natl Acad Sci USA 119:e2123231119","journal-title":"Proc Natl Acad Sci USA"},{"key":"773_CR266","doi-asserted-by":"publisher","unstructured":"Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, Pei G (2009) Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell. https:\/\/doi.org\/10.1016\/j.cell.2009.08.038","DOI":"10.1016\/j.cell.2009.08.038"},{"key":"773_CR267","doi-asserted-by":"publisher","first-page":"958","DOI":"10.3390\/cancers11070958","volume":"11","author":"CC Yun","year":"2019","unstructured":"Yun CC (2019) Lysophosphatidic acid and Autotaxin-associated effects on the initiation and progression of colorectal cancer. Cancers (Basel) 11:958","journal-title":"Cancers (Basel)"},{"key":"773_CR268","doi-asserted-by":"publisher","first-page":"1543","DOI":"10.3390\/ijms19051543","volume":"19","author":"CM Zeng","year":"2018","unstructured":"Zeng CM, Chen Z, Fu L (2018) Frizzled receptors as potential therapeutic targets in human cancers. Int J Mol Sci 19:1543","journal-title":"Int J Mol Sci"},{"key":"773_CR269","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154197","volume":"240","author":"S Zeng","year":"2022","unstructured":"Zeng S, Liang Y, Hu H, Wang F, Liang L (2022) Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer. Pathol Res Pract 240:154197","journal-title":"Pathol Res Pract"},{"key":"773_CR270","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.136","volume":"7","author":"Y Zhan","year":"2016","unstructured":"Zhan Y, Xu C, Liu Z, Yang Y, Tan S, Yang Y, Jiang J, Liu H, Chen J, Wu B (2016) Beta-Arrestin1 inhibits chemotherapy-induced intestinal stem cell apoptosis and mucositis. Cell Death Dis 7:e2229","journal-title":"Cell Death Dis"},{"key":"773_CR271","first-page":"1203","volume":"20","author":"H Zhang","year":"2019","unstructured":"Zhang H, He B (2019) SDF1\/CXCR4 axis plays a role in angiogenesis during the degeneration of intervertebral discs. Mol Med Rep 20:1203\u20131211","journal-title":"Mol Med Rep"},{"key":"773_CR272","doi-asserted-by":"publisher","first-page":"3801","DOI":"10.4049\/jimmunol.0801548","volume":"182","author":"Y Zhang","year":"2009","unstructured":"Zhang Y, Liu Q, Zhang M, Yu Y, Liu X, Cao X (2009) Fas signal promotes lung cancer growth by recruiting myeloid-derived suppressor cells via cancer cell-derived PGE2. J Immunol 182:3801\u20133808","journal-title":"J Immunol"},{"key":"773_CR273","doi-asserted-by":"publisher","first-page":"8933","DOI":"10.1074\/jbc.M116.770420","volume":"292","author":"YX Zhang","year":"2017","unstructured":"Zhang YX, Li XF, Yuan GQ, Hu H, Song XY, Li JY, Miao XK, Zhou TX, Yang WL, Zhang XW, Mou LY, Wang R (2017) Beta-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G(2)\/M phase transition. J Biol Chem 292:8933\u20138947","journal-title":"J Biol Chem"},{"key":"773_CR274","first-page":"1294","volume":"10","author":"L Zhang","year":"2020","unstructured":"Zhang L, Pan J, Chen W, Jiang J, Huang J (2020a) Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment. Am J Cancer Res 10:1294\u20131307","journal-title":"Am J Cancer Res"},{"key":"773_CR275","first-page":"2741","volume":"36","author":"L Zhang","year":"2020","unstructured":"Zhang L, Wang F, Yao X, Ma S, Zhang L, Qin Z (2020b) Progress in targeting therapy of cancer metastasis by CCL21\/CCR7 axis. Sheng Wu Gong Cheng Xue Bao 36:2741\u20132754","journal-title":"Sheng Wu Gong Cheng Xue Bao"},{"key":"773_CR276","doi-asserted-by":"publisher","first-page":"6000","DOI":"10.1038\/s41467-020-19849-9","volume":"11","author":"Y Zhang","year":"2020","unstructured":"Zhang Y, Li M, Li L, Qian G, Wang Y, Chen Z, Liu J, Fang C, Huang F, Guo D, Zou Q, Chu Y, Yan D (2020c) Beta-arrestin 2 as an activator of cGAS-STING signaling and target of viral immune evasion. Nat Commun 11:6000","journal-title":"Nat Commun"},{"key":"773_CR277","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.4149\/neo_2022_220513N511","volume":"69","author":"M Zhang","year":"2022","unstructured":"Zhang M, Guan WB, Li JL, Li LX, Wang KZ, Wang RF, Wang LF (2022) Cancer-associated fibroblasts subtypes and role in invasion and metastasis of gastric cancer. Neoplasma 69:1277\u20131288","journal-title":"Neoplasma"},{"key":"773_CR278","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1186\/s12943-024-02156-y","volume":"23","author":"A Zhang","year":"2024","unstructured":"Zhang A, Fan T, Liu Y, Yu G, Li C, Jiang Z (2024a) Regulatory T cells in immune checkpoint blockade antitumor therapy. Mol Cancer 23:251","journal-title":"Mol Cancer"},{"key":"773_CR279","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41392-024-01848-7","volume":"9","author":"S Zhang","year":"2024","unstructured":"Zhang S, Xiao X, Yi Y, Wang X, Zhu L, Shen Y, Lin D, Chen W (2024b) Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets. Signal Transduct Target Ther 9:149","journal-title":"Signal Transduct Target Ther"},{"key":"773_CR280","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1016\/B978-0-12-394440-5.00016-4","volume":"118","author":"J Zhao","year":"2013","unstructured":"Zhao J, Pei G (2013) Arrestins in metabolic regulation. Prog Mol Biol Transl Sci 118:413\u2013427","journal-title":"Prog Mol Biol Transl Sci"},{"key":"773_CR281","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/978-1-4939-9158-7_14","volume":"1957","author":"Y Zhao","year":"2019","unstructured":"Zhao Y, Xiao K (2019) Proteomic analysis of the beta-Arrestin Interactomes. Methods Mol Biol 1957:217\u2013232","journal-title":"Methods Mol Biol"},{"key":"773_CR282","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1158\/1078-0432.CCR-08-1611","volume":"15","author":"P Zhou","year":"2009","unstructured":"Zhou P, Zheng X, Zhang H, Liu Y, Zheng P (2009) B7 blockade alters the balance between regulatory T cells and tumor-reactive T cells for immunotherapy of cancer. Clin Cancer Res 15:960\u2013970","journal-title":"Clin Cancer Res"},{"key":"773_CR283","first-page":"801","volume":"16","author":"Y Zhou","year":"2018","unstructured":"Zhou Y, Cao HB, Li WJ, Zhao L (2018) The CXCL12 (SDF-1)\/CXCR4 chemokine axis: oncogenic properties, molecular targeting, and synthetic and natural product CXCR4 inhibitors for cancer therapy. Chin J Nat Med 16:801\u2013810","journal-title":"Chin J Nat Med"},{"key":"773_CR284","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1186\/1471-2407-8-218","volume":"8","author":"YM Zhu","year":"2008","unstructured":"Zhu YM, Azahri NS, Yu DC, Woll PJ (2008) Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. BMC Cancer 8:218","journal-title":"BMC Cancer"},{"key":"773_CR285","doi-asserted-by":"publisher","unstructured":"Zhuang LN, Hu W-x, Xin S-m, Zhao J, Pei G (2011) Beta-arrestin-1 protein represses adipogenesis and inflammatory responses through its interaction with peroxisome proliferator-activated receptor-gamma (PPARgamma). J Biol Chem. https:\/\/doi.org\/10.1074\/jbc.M111.256099","DOI":"10.1074\/jbc.M111.256099"},{"key":"773_CR286","doi-asserted-by":"crossref","unstructured":"Zielinska KA, Katanaev VL (2020) The signaling duo CXCL12 and CXCR4: chemokine fuel for breast Cancer tumorigenesis. Cancers (Basel) 12","DOI":"10.3390\/cancers12103071"},{"key":"773_CR287","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1096\/fj.07-9046com","volume":"22","author":"L Zou","year":"2008","unstructured":"Zou L, Yang R, Chai J, Pei G (2008) Rapid xenograft tumor progression in beta-arrestin1 transgenic mice due to enhanced tumor angiogenesis. FASEB J 22:355\u2013364","journal-title":"FASEB J"},{"key":"773_CR288","doi-asserted-by":"publisher","first-page":"20634","DOI":"10.1074\/jbc.M701391200","volume":"282","author":"M Zoudilova","year":"2007","unstructured":"Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA (2007) Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. J Biol Chem 282:20634\u201320646","journal-title":"J Biol Chem"}],"container-title":["Handbook of Experimental Pharmacology","Pharmacology of GPCRs Biased Signaling and Agonists"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2025_773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T23:22:33Z","timestamp":1767309753000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2025_773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"ISBN":["9783032132284","9783032132291"],"references-count":288,"URL":"https:\/\/doi.org\/10.1007\/164_2025_773","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"type":"print","value":"0171-2004"},{"type":"electronic","value":"1865-0325"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"30 October 2025","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}