{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:10:36Z","timestamp":1787238636407,"version":"build-2736575974"},"publisher-location":"Berlin, Heidelberg","reference-count":189,"publisher":"Springer Berlin Heidelberg","content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026]]},"DOI":"10.1007\/164_2026_803","type":"book-chapter","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:28:36Z","timestamp":1779132516000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Are There Common Mechanisms and Consequences of Placental Endothelial Dysfunction in Women with Gestational Diabetes Mellitus and Pre-eclampsia?"],"prefix":"10.1007","author":[{"given":"Katherin","family":"Silva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Carlos","family":"Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilcia","family":"Sauceda-Acosta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Sobrevia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"issue":"1","key":"803_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","volume":"170","author":"E Abalos","year":"2013","unstructured":"Abalos E, Cuesta C, Grosso AL, Chou D, Say L (2013) Global and regional estimates of preeclampsia and eclampsia: a systematic review. Eur J Obstet Gynecol Reprod Biol 170(1):1\u20137. https:\/\/doi.org\/10.1016\/j.ejogrb.2013.05.005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"803_CR2","doi-asserted-by":"publisher","first-page":"1036","DOI":"10.4236\/ojog.2020.1080097","volume":"10","author":"A Aboelfath","year":"2020","unstructured":"Aboelfath A, Sharaf El din M (2020) Predictive factors of successful treatment of gestational diabetes with metformin monotherapy. Open J Obstet Gynecol 10:1036\u20131044. https:\/\/doi.org\/10.4236\/ojog.2020.1080097","journal-title":"Open J Obstet Gynecol"},{"issue":"9","key":"803_CR3","doi-asserted-by":"publisher","first-page":"2018","DOI":"10.2337\/dc10-0572","volume":"33","author":"MM Agarwal","year":"2010","unstructured":"Agarwal MM, Dhatt GS, Shah SM (2010) Gestational diabetes mellitus: simplifying the international association of diabetes and pregnancy diagnostic algorithm using fasting plasma glucose. Diabetes Care 33(9):2018\u20132020. https:\/\/doi.org\/10.2337\/dc10-0572","journal-title":"Diabetes Care"},{"issue":"9321","key":"803_CR4","doi-asserted-by":"publisher","first-page":"1877","DOI":"10.1016\/S0140-6736(02)08778-0","volume":"359","author":"D Altman","year":"2002","unstructured":"Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J, Smith D, Magpie Trial Collaboration Group (2002) Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo-controlled trial. Lancet 359(9321):1877\u20131890. https:\/\/doi.org\/10.1016\/S0140-6736(02)08778-0","journal-title":"Lancet"},{"issue":"2","key":"803_CR5","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1097\/AOG.0000000000002498","volume":"131","author":"American College of Obstetricians and Gynecologists (ACOG)","year":"2018","unstructured":"American College of Obstetricians and Gynecologists (ACOG) (2018) Practice Bulletin No. 190 summary: gestational diabetes mellitus. Obstet Gynecol 131(2):406\u2013408. https:\/\/doi.org\/10.1097\/AOG.0000000000002498","journal-title":"Obstet Gynecol"},{"issue":"6","key":"803_CR6","doi-asserted-by":"publisher","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","volume":"135","author":"American College of Obstetricians and Gynecologists (ACOG)","year":"2020","unstructured":"American College of Obstetricians and Gynecologists (ACOG) (2020) Gestational hypertension and preeclampsia. Practice Bulletin, Number 222. Obstet Gynecol 135(6):e237\u2013e260. https:\/\/doi.org\/10.1097\/AOG.0000000000003891","journal-title":"Obstet Gynecol"},{"issue":"Suppl 1","key":"803_CR7","doi-asserted-by":"publisher","first-page":"S282","DOI":"10.2337\/dc24-S015","volume":"47","author":"American Diabetes Association Professional Practice Committee","year":"2024","unstructured":"American Diabetes Association Professional Practice Committee (2024) 15. Management of Diabetes in pregnancy: standards of care in diabetes-2024. Diabetes Care 47(Suppl 1):S282\u2013S294. https:\/\/doi.org\/10.2337\/dc24-S015","journal-title":"Diabetes Care"},{"issue":"Suppl 1","key":"803_CR8","doi-asserted-by":"publisher","first-page":"S27","DOI":"10.2337\/dc26-S002","volume":"49","author":"American Diabetes Association Professional Practice Committee for Diabetes*","year":"2026","unstructured":"American Diabetes Association Professional Practice Committee for Diabetes* (2026) 2. Diagnosis and classification of diabetes: standards of care in diabetes\u20142026. Diabetes Care 49(Suppl 1):S27\u2013S49. https:\/\/doi.org\/10.2337\/dc26-S002","journal-title":"Diabetes Care"},{"issue":"9","key":"803_CR9","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","volume":"16","author":"JD Aplin","year":"2020","unstructured":"Aplin JD, Myers JE, Timms K, Westwood M (2020) Tracking placental development in health and disease. Nat Rev Endocrinol 16(9):479\u2013494. https:\/\/doi.org\/10.1038\/s41574-020-0372-6","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"803_CR10","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1134\/S0012496623700722","volume":"513","author":"KA Artemieva","year":"2023","unstructured":"Artemieva KA, Stepanova YV, Stepanova II, Shamarakova MV, Tikhonova NB, Nizyaeva NV, Tsakhilova SG, Mikhaleva LM (2023) Morfofunctional and molecular changes in placenta and peripheral blood in preeclampsia and gestational diabetes mellitus. Dokl Biol Sci 513(1):387\u2013394. https:\/\/doi.org\/10.1134\/S0012496623700722","journal-title":"Dokl Biol Sci"},{"issue":"1","key":"803_CR11","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1186\/s12872-025-04941-z","volume":"25","author":"P Asiimwe","year":"2025","unstructured":"Asiimwe P, Nambozi G, Brennaman L, Ngonzi J, Ruzaaza G (2025) Effectiveness of low-dose aspirin in reducing the risk of preeclampsia in women with chronic hypertension: an integrative literature review. BMC Cardiovasc Disord 25(1):554. https:\/\/doi.org\/10.1186\/s12872-025-04941-z","journal-title":"BMC Cardiovasc Disord"},{"key":"803_CR12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h102","volume":"350","author":"M Balsells","year":"2015","unstructured":"Balsells M, Garc\u00eda-Patterson A, Sol\u00e0 I, Roqu\u00e9 M, Gich I, Corcoy R (2015) Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. BMJ 350:h102. https:\/\/doi.org\/10.1136\/bmj.h102","journal-title":"BMJ"},{"issue":"12","key":"803_CR13","doi-asserted-by":"publisher","first-page":"2025","DOI":"10.3390\/nu17122025","volume":"17","author":"D Baroutis","year":"2025","unstructured":"Baroutis D, Katsianou E, Athanasiou D, Giannakaki AG, Antsaklis P, Theodora M, Daskalakis G, Eleftheriades M (2025) DASH diet and preeclampsia prevention: a literature review. Nutrients 17(12):2025. https:\/\/doi.org\/10.3390\/nu17122025","journal-title":"Nutrients"},{"key":"803_CR14","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2024.111890","volume":"217","author":"B Bastian","year":"2024","unstructured":"Bastian B, Smithers LG, Pape A, Davis W, Fu K, Francois M (2024) Early screening and diagnosis of gestational diabetes mellitus (GDM) and its impact on perinatal outcomes. Diab Res Clin Prac 217:111890. https:\/\/doi.org\/10.1016\/j.diabres.2024.111890","journal-title":"Diab Res Clin Prac"},{"issue":"2","key":"803_CR15","doi-asserted-by":"publisher","first-page":"92","DOI":"10.2337\/diaspect.29.2.92","volume":"29","author":"AK Blum","year":"2016","unstructured":"Blum AK (2016) Insulin use in pregnancy: an update. Diabetes Spectr 29(2):92\u201397. https:\/\/doi.org\/10.2337\/diaspect.29.2.92","journal-title":"Diabetes Spectr"},{"issue":"3","key":"803_CR16","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1161\/HYPERTENSIONAHA.121.18415","volume":"79","author":"JN Bone","year":"2022","unstructured":"Bone JN, Sandhu A, Abalos ED, Khalil A, Singer J, Prasad S, Omar S, Vidler M, von Dadelszen P, Magee LA (2022) Oral antihypertensives for nonsevere pregnancy hypertension: systematic review, network meta- and trial sequential analyses. Hypertension 79(3):614\u2013628. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.121.18415","journal-title":"Hypertension"},{"issue":"24","key":"803_CR18","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","volume":"54","author":"FC Bull","year":"2020","unstructured":"Bull FC, Al-Ansari SS, Biddle S, Borodulin K, Buman MP, Cardon G, Carty C, Chaput JP, Chastin S, Chou R, Dempsey PC, DiPietro L, Ekelund U, Firth J, Friedenreich CM, Garcia L, Gichu M, Jago R, Katzmarzyk PT, Lambert E, Leitzmann M, Milton K, Ortega FB, Ranasinghe C, Stamatakis E, Tiedemann A, Troiano RP, van der Ploeg HP, Wari V, Willumsen JF (2020) World Health Organization 2020 guidelines on physical activity and sedentary behaviour. Br J Sports Med 54(24):1451\u20131462. https:\/\/doi.org\/10.1136\/bjsports-2020-102955","journal-title":"Br J Sports Med"},{"issue":"4","key":"803_CR19","doi-asserted-by":"publisher","first-page":"S6.e1","DOI":"10.1016\/j.ajog.2015.07.050","volume":"213","author":"GJ Burton","year":"2015","unstructured":"Burton GJ, Jauniaux E (2015) What is the placenta? Am J Obstet Gynecol 213(4):S6.e1\u2013S6.e4. https:\/\/doi.org\/10.1016\/j.ajog.2015.07.050","journal-title":"Am J Obstet Gynecol"},{"key":"803_CR20","doi-asserted-by":"publisher","unstructured":"Byford AR, Fakonti G, Shao Z, Soni S, Earle SL, Bajarwan M, Morley LC, Holder B, Scott EM, Forbes K (2025) Endothelial-to-mesenchymal transition in the fetoplacental macrovasculature and microvasculature in pregnancies complicated by gestational diabetes. J Physiol. https:\/\/doi.org\/10.1113\/JP287931","DOI":"10.1113\/JP287931"},{"key":"803_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.mam.2019.01.001","volume":"66","author":"C Cabal\u00edn","year":"2019","unstructured":"Cabal\u00edn C, Villalobos-Labra R, Toledo F, Sobrevia L (2019) Involvement of A2B adenosine receptors as anti-inflammatory in gestational diabesity. Mol Asp Med 66:31\u201339. https:\/\/doi.org\/10.1016\/j.mam.2019.01.001","journal-title":"Mol Asp Med"},{"issue":"8","key":"803_CR22","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.1111\/dom.16450","volume":"27","author":"Y Cai","year":"2025","unstructured":"Cai Y, Liu J, Wang Q, Ren X, Xie J, Yu J, Xiao Y, Zhang Y, Chen X, Hong A (2025) Mechanisms of vascular endothelial cell injury triggered by blood glucose changes in gestational diabetes mellitus. Diabetes Obes Metab 27(8):4203\u20134219. https:\/\/doi.org\/10.1111\/dom.16450","journal-title":"Diabetes Obes Metab"},{"key":"803_CR23","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.placenta.2021.05.002","volume":"113","author":"I Carrasco-Wong","year":"2021","unstructured":"Carrasco-Wong I, Aguilera-Olgu\u00edn M, Escalona-Rivano R et al (2021) Syncytiotrophoblast stress in early onset preeclampsia: the issues perpetuating the syndrome. Placenta 113:57\u201366. https:\/\/doi.org\/10.1016\/j.placenta.2021.05.002","journal-title":"Placenta"},{"key":"803_CR1000","doi-asserted-by":"publisher","unstructured":"Cawyer CR, Horvat D, Leonard D, Allen SR, Jones RO, Zawieja DC, Kuehl TJ, Uddin MN (2014) Hyperglycemia impairs cytotrophoblast function via stress signaling. Am J Obstet Gynecol 211(5):541.e1-8. https:\/\/doi.org\/10.1016\/j.ajog.2014.04.033","DOI":"10.1016\/j.ajog.2014.04.033"},{"issue":"8","key":"803_CR24","doi-asserted-by":"publisher","first-page":"1620","DOI":"10.2337\/dbi22-0015","volume":"71","author":"L Chen","year":"2022","unstructured":"Chen L (2022) Metabolomic markers in early pregnancy for gestational diabetes mellitus. Diabetes 71(8):1620\u20131622. https:\/\/doi.org\/10.2337\/dbi22-0015","journal-title":"Diabetes"},{"key":"803_CR25","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanwpc.2025.101582","volume":"59","author":"Y Chen","year":"2025","unstructured":"Chen Y, Nguyen-Hoang L, Dinh LT, Nguyen DA, Pooh RK, Shiozaki A, Zheng M, Hu Y, Ma R, Kusuma A, Wataganara T, Choolani MA, Kaneko M, Luewan S, Chang TY, Chaiyasit N, Nanthakomon T, Jiang Y, Shaw SW, Leung WC, Mohamad AS, Aguilar A, Lau SL, Lee NMW, Liu J, Sahota DS, Chong MKC, Papastefanou I, Poon LC (2025a) Effect of aspirin on small for gestational age neonates in pregnancies at high-risk for preeclampsia: a secondary analysis of a cluster randomised clinical trial. Lancet Reg Health West Pac 59:101582. https:\/\/doi.org\/10.1016\/j.lanwpc.2025.101582","journal-title":"Lancet Reg Health West Pac"},{"key":"803_CR26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2024.156802","volume":"185","author":"X Chen","year":"2025","unstructured":"Chen X, Nie X, Lin X, Wang Y, Zhang L, Chen Z, Lin M (2025b) Regulation of keratinocyte barrier function and inflammatory response by the EGFR-STAT3 pathway: potential therapeutic implications of osimertinib and afatinib. Cytokine 185:156802. https:\/\/doi.org\/10.1016\/j.cyto.2024.156802","journal-title":"Cytokine"},{"issue":"8","key":"803_CR27","doi-asserted-by":"publisher","first-page":"4532","DOI":"10.3390\/ijms25084532","volume":"25","author":"YT Chiang","year":"2024","unstructured":"Chiang YT, Seow KM, Chen KH (2024) The pathophysiological, genetic, and hormonal changes in preeclampsia: a systematic review of the molecular mechanisms. Int J Mol Sci 25(8):4532. https:\/\/doi.org\/10.3390\/ijms25084532","journal-title":"Int J Mol Sci"},{"key":"803_CR28","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.placenta.2018.04.011","volume":"69","author":"DI Chiarello","year":"2018","unstructured":"Chiarello DI, Mar\u00edn R, Proverbio F, Coronado P, Toledo F, Salsoso R, Guti\u00e9rrez J, Sobrevia L (2018a) Mechanisms of the effect of magnesium salts in preeclampsia. Placenta 69:134\u2013139. https:\/\/doi.org\/10.1016\/j.placenta.2018.04.011","journal-title":"Placenta"},{"key":"803_CR29","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.mam.2017.12.002","volume":"60","author":"DI Chiarello","year":"2018","unstructured":"Chiarello DI, Salsoso R, Toledo F, Mate A, V\u00e1zquez CM, Sobrevia L (2018b) Foetoplacental communication via extracellular vesicles in normal pregnancy and preeclampsia. Mol Asp Med 60:69\u201380. https:\/\/doi.org\/10.1016\/j.mam.2017.12.002","journal-title":"Mol Asp Med"},{"key":"803_CR30","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.semcdb.2022.03.039","volume":"131","author":"T Cindrova-Davies","year":"2022","unstructured":"Cindrova-Davies T, Sferruzzi-Perri AN (2022) Human placental development and function. Semin Cell Dev Biol 131:66\u201377. https:\/\/doi.org\/10.1016\/j.semcdb.2022.03.039","journal-title":"Semin Cell Dev Biol"},{"issue":"4","key":"803_CR31","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13671","volume":"232","author":"M Cornejo","year":"2021","unstructured":"Cornejo M, Fuentes G, Valero P, Vega S, Grismaldo A, Toledo F, Pardo F, Moore-Carrasco R, Subiabre M, Casanello P, Faas MM, van Goor H, Sobrevia L (2021) Gestational diabesity and foetoplacental vascular dysfunction. Acta Physiol (Oxf) 232(4):e13671. https:\/\/doi.org\/10.1111\/apha.13671","journal-title":"Acta Physiol (Oxf)"},{"issue":"4","key":"803_CR32","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsem-2024-002176","volume":"10","author":"EJM C\u00f4t\u00e9","year":"2024","unstructured":"C\u00f4t\u00e9 EJM, Benton M, Gardner R, Tribe R (2024) Balancing benefits and risks of exercise in pregnancy: a qualitative analysis of social media discussion. BMJ Open Sport Exerc Med 10(4):e002176. https:\/\/doi.org\/10.1136\/bmjsem-2024-002176","journal-title":"BMJ Open Sport Exerc Med"},{"issue":"7","key":"803_CR33","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1161\/CIRCULATIONAHA.124.073302","volume":"151","author":"M Countouris","year":"2025","unstructured":"Countouris M, Mahmoud Z, Cohen JB, Crousillat D, Hameed AB, Harrington CM, Hauspurg A, Honigberg MC, Lewey J, Lindley K, McLaughlin MM, Sachdev N, Sarma A, Shapero K, Sinkey R, Tita A, Wong KE, Yang E, Cho L, Bello NA (2025) Hypertension in pregnancy and postpartum: current standards and opportunities to improve care. Circulation 151(7):490\u2013507. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.124.073302","journal-title":"Circulation"},{"key":"803_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-3-031-32554-0_1","volume":"1428","author":"A Covarrubias","year":"2023","unstructured":"Covarrubias A, Aguilera-Olgu\u00edn M, Carrasco-Wong I, Pardo F, D\u00edaz-Astudillo P, Mart\u00edn SS (2023) Feto-placental unit: from development to function. Adv Exp Med Biol 1428:1\u201329. https:\/\/doi.org\/10.1007\/978-3-031-32554-0_1","journal-title":"Adv Exp Med Biol"},{"issue":"7","key":"803_CR35","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13071126","volume":"13","author":"PHCM da Silva","year":"2023","unstructured":"da Silva PHCM, Santos KF, da Silva L, da Costa CCP, Santos RDS, Reis AADS (2023) MicroRNAs associated with the pathophysiological mechanisms of gestational diabetes mellitus: a systematic review for building a panel of miRNAs. J Pers Med 13(7):1126. https:\/\/doi.org\/10.3390\/jpm13071126","journal-title":"J Pers Med"},{"issue":"14","key":"803_CR36","doi-asserted-by":"publisher","first-page":"1705","DOI":"10.1093\/cvr\/cvx202","volume":"113","author":"SCA de Jager","year":"2017","unstructured":"de Jager SCA, Hoefer IE (2017) Beyond the matrix: MMP2 as critical regulator of inflammation-mediated vascular dysfunction. Cardiovasc Res 113(14):1705\u20131707. https:\/\/doi.org\/10.1093\/cvr\/cvx202","journal-title":"Cardiovasc Res"},{"issue":"5","key":"803_CR37","doi-asserted-by":"publisher","first-page":"658","DOI":"10.4103\/2230-8210.163202","volume":"19","author":"MC Deepaklal","year":"2015","unstructured":"Deepaklal MC, Joseph K, Rekha K, Nandita T (2015) Insulin aspart in patients with gestational diabetes mellitus and pregestational diabetes mellitus. Indian J Endocrinol Metab 19(5):658\u2013662. https:\/\/doi.org\/10.4103\/2230-8210.163202","journal-title":"Indian J Endocrinol Metab"},{"issue":"4","key":"803_CR38","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1038\/s41581-022-00670-0","volume":"19","author":"E Deer","year":"2023","unstructured":"Deer E, Herrock O, Campbell N, Cornelius D, Fitzgerald S, Amaral LM, LaMarca B (2023) The role of immune cells and mediators in preeclampsia. Nat Rev Nephrol 19(4):257\u2013270. https:\/\/doi.org\/10.1038\/s41581-022-00670-0","journal-title":"Nat Rev Nephrol"},{"key":"803_CR39","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/5142918","volume":"2022","author":"D Di Filippo","year":"2022","unstructured":"Di Filippo D, Ahmadzai M, Chang MHY, Horgan K, Ong RM, Darling J, Akhtar M, Henry A, Welsh A (2022) Continuous glucose monitoring for the diagnosis of gestational diabetes mellitus: a pilot study. J Diabetes Res 2022:5142918. https:\/\/doi.org\/10.1155\/2022\/5142918","journal-title":"J Diabetes Res"},{"issue":"1","key":"803_CR40","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1186\/s12884-023-05496-7","volume":"23","author":"D Di Filippo","year":"2023","unstructured":"Di Filippo D, Henry A, Bell C, Haynes S, Chang MHY, Darling J, Welsh A (2023) A new continuous glucose monitor for the diagnosis of gestational diabetes mellitus: a pilot study. BMC Pregnancy Childbirth 23(1):186. https:\/\/doi.org\/10.1186\/s12884-023-05496-7","journal-title":"BMC Pregnancy Childbirth"},{"issue":"12","key":"803_CR41","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.numecd.2014.06.005","volume":"24","author":"P Di Fulvio","year":"2014","unstructured":"Di Fulvio P, Pandolfi A, Formoso G, Di Silvestre S, Di Tomo P, Giardinelli A, De Marco A, Di Pietro N, Taraborrelli M, Sancilio S, Di Pietro R, Piantelli M, Consoli A (2014) Features of endothelial dysfunction in umbilical cord vessels of women with gestational diabetes. Nutr Metab Cardiovasc Dis 24(12):1337\u20131345. https:\/\/doi.org\/10.1016\/j.numecd.2014.06.005","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"1\u20132","key":"803_CR42","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1080\/19336918.2015.1127467","volume":"10","author":"FI D\u00edaz-P\u00e9rez","year":"2016","unstructured":"D\u00edaz-P\u00e9rez FI, Hiden U, Gauster M, Lang I, Konya V, Heinemann A, L\u00f6gl J, Saffery R, Desoye G, Cvitic S (2016) Post-transcriptional down regulation of ICAM-1 in feto-placental endothelium in GDM. Cell Adhes Migr 10(1\u20132):18\u201327. https:\/\/doi.org\/10.1080\/19336918.2015.1127467","journal-title":"Cell Adhes Migr"},{"issue":"1","key":"803_CR43","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-22-0170","volume":"256","author":"S Dinesen","year":"2022","unstructured":"Dinesen S, El-Faitarouni A, Dalgaard LT (2022) Circulating microRNAs associated with gestational diabetes mellitus: useful biomarkers? J Endocrinol 256(1):e220170. https:\/\/doi.org\/10.1530\/JOE-22-0170","journal-title":"J Endocrinol"},{"issue":"7","key":"803_CR44","doi-asserted-by":"publisher","first-page":"6186","DOI":"10.3390\/ijms24076186","volume":"24","author":"S Dinesen","year":"2023","unstructured":"Dinesen S, El-Faitarouni A, Frisk NLS, S\u00f8rensen AE, Dalgaard LT (2023) Circulating microRNA as biomarkers for gestational diabetes mellitus-a systematic review and meta-analysis. Int J Mol Sci 24(7):6186. https:\/\/doi.org\/10.3390\/ijms24076186","journal-title":"Int J Mol Sci"},{"issue":"2","key":"803_CR45","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.3390\/ijms24021795","volume":"24","author":"CX Dong","year":"2023","unstructured":"Dong CX, Malecki C, Robertson E, Hambly B, Jeremy R (2023) Molecular mechanisms in genetic aortopathy-signaling pathways and potential interventions. Int J Mol Sci 24(2):1795. https:\/\/doi.org\/10.3390\/ijms24021795","journal-title":"Int J Mol Sci"},{"issue":"7","key":"803_CR46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201319","volume":"13","author":"BM Donovan","year":"2018","unstructured":"Donovan BM, Nidey NL, Jasper EA, Robinson JG, Bao W, Saftlas AF, Ryckman KK (2018) First trimester prenatal screening biomarkers and gestational diabetes mellitus: a systematic review and meta-analysis. PLoS One 13(7):e0201319. https:\/\/doi.org\/10.1371\/journal.pone.0201319","journal-title":"PLoS One"},{"issue":"1","key":"803_CR47","doi-asserted-by":"publisher","first-page":"60","DOI":"10.3390\/jpm13010060","volume":"13","author":"Y Duo","year":"2022","unstructured":"Duo Y, Song S, Zhang Y, Qiao X, Xu J, Zhang J, Peng Z, Chen Y, Nie X, Sun Q, Yang X, Wang A, Sun W, Fu Y, Dong Y, Lu Z, Yuan T, Zhao W (2022) Predictability of HOMA-IR for gestational diabetes mellitus in early pregnancy based on different first trimester bmi values. J Pers Med 13(1):60. https:\/\/doi.org\/10.3390\/jpm13010060","journal-title":"J Pers Med"},{"issue":"1","key":"803_CR49","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04269-2","volume":"21","author":"DA Elhag","year":"2023","unstructured":"Elhag DA, Al Khodor S (2023) Exploring the potential of microRNA as a diagnostic tool for gestational diabetes. J Transl Med 21(1):392. https:\/\/doi.org\/10.1186\/s12967-023-04269-2","journal-title":"J Transl Med"},{"issue":"7","key":"803_CR50","doi-asserted-by":"publisher","first-page":"1448","DOI":"10.3390\/ijms18071448","volume":"18","author":"Y Espino","year":"2017","unstructured":"Espino Y, Sosa S, Flores-Pliego A, Espejel-Nu\u00f1ez A, Medina-Bastidas D, Vadillo-Ortega F, Zaga-Clavellina V, Estrada-Gutierrez G (2017) New insights into the role of matrix metalloproteinases in preeclampsia. Int J Mol Sci 18(7):1448. https:\/\/doi.org\/10.3390\/ijms18071448","journal-title":"Int J Mol Sci"},{"key":"803_CR51","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.freeradbiomed.2025.06.007","volume":"237","author":"K Etchegaray-Armijo","year":"2025","unstructured":"Etchegaray-Armijo K, Bustos-Arriagada E, Navarro-Rosenblatt D, Vera C, Garmendia ML, Sobrevia L, L\u00f3pez-Alarc\u00f3n C, Casanello P (2025) Biomarkers of oxidative stress in maternal plasma, umbilical cord and placenta of patients with gestational diabetes: a systematic review and meta-analysis. Free Radic Biol Med 237:650\u2013665. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2025.06.007","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"803_CR52","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1093\/cvr\/cvp410","volume":"86","author":"M Far\u00edas","year":"2010","unstructured":"Far\u00edas M, Puebla C, Westermeier F, Jo MJ, Pastor-Anglada M, Casanello P, Sobrevia L (2010) Nitric oxide reduces SLC29A1 promoter activity and adenosine transport involving transcription factor complex hCHOP-C\/EBPalpha in human umbilical vein endothelial cells from gestational diabetes. Cardiovasc Res 86(1):45\u201354. https:\/\/doi.org\/10.1093\/cvr\/cvp410","journal-title":"Cardiovasc Res"},{"issue":"6","key":"803_CR53","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1111\/aogs.13540","volume":"98","author":"EJ Flint","year":"2019","unstructured":"Flint EJ, Cerdeira AS, Redman CW, Vatish M (2019) The role of angiogenic factors in the management of preeclampsia. Acta Obstet Gynecol Scand 98(6):700\u2013707. https:\/\/doi.org\/10.1111\/aogs.13540","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"3","key":"803_CR54","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1161\/ATVBAHA.114.304730","volume":"35","author":"I Floris","year":"2015","unstructured":"Floris I, Descamps B, Vardeu A, Miti\u0107 T, Posadino AM, Shantikumar S, Sala-Newby G, Capobianco G, Mangialardi G, Howard L, Dessole S, Urrutia R, Pintus G, Emanueli C (2015) Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2. Arterioscler Thromb Vasc Biol 35(3):664\u2013674. https:\/\/doi.org\/10.1161\/ATVBAHA.114.304730","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"803_CR55","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1002\/uog.7621","volume":"35","author":"JM Foidart","year":"2010","unstructured":"Foidart JM, Munaut C, Chantraine F, Akolekar R, Nicolaides KH (2010) Maternal plasma soluble endoglin at 11-13 weeks\u2019 gestation in pre-eclampsia. Ultrasound Obstet Gynecol 35(6):680\u2013687. https:\/\/doi.org\/10.1002\/uog.7621","journal-title":"Ultrasound Obstet Gynecol"},{"key":"803_CR56","doi-asserted-by":"publisher","first-page":"1618","DOI":"10.1007\/s00125-026-06679-5","volume":"69","author":"G Fuentes","year":"2026","unstructured":"Fuentes G, Valero P, Cornejo M, Silva K, Ram\u00edrez MA, Gonz\u00e1lez DR, Hillebrands JL, van Goor H, Sobrevia L (2026) Maternal pre-pregnancy BMI differentially regulates intracellular pH in human umbilical vein endothelium from gestational diabetes mellitus pregnancies, with alkalinisation-associated reduction of adenosine transport in normal weight pregnancies. Diabetologia 69:1618\u20131642. https:\/\/doi.org\/10.1007\/s00125-026-06679-5","journal-title":"Diabetologia"},{"issue":"2","key":"803_CR57","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.bpobgyn.2014.04.025","volume":"29","author":"R Gabbay-Benziv","year":"2015","unstructured":"Gabbay-Benziv R, Baschat AA (2015) Gestational diabetes as one of the \u201cgreat obstetrical syndromes\u201d\u2013the maternal, placental, and fetal dialog. Best Pract Res Clin Obstet Gynaecol 29(2):150\u2013155. https:\/\/doi.org\/10.1016\/j.bpobgyn.2014.04.025","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"issue":"1","key":"803_CR58","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1530\/EJE-17-0486","volume":"178","author":"I Gante","year":"2018","unstructured":"Gante I, Melo L, Dores J, Ruas L, Almeida MDC (2018) Metformin in gestational diabetes mellitus: predictors of poor response. Eur J Endocrinol 178(1):129\u2013135. https:\/\/doi.org\/10.1530\/EJE-17-0486","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"803_CR59","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbad489","volume":"25","author":"D Gao","year":"2023","unstructured":"Gao D, Ren L, Hao YD, Schaduangrat N, Liu XW, Yuan SS, Yang YH, Wang Y, Shoombuatong W, Ding H (2023) The role of ncRNA regulatory mechanisms in diseases-case on gestational diabetes. Brief Bioinform 25(1):bbad489. https:\/\/doi.org\/10.1093\/bib\/bbad489","journal-title":"Brief Bioinform"},{"issue":"2","key":"803_CR60","doi-asserted-by":"publisher","first-page":"e21","DOI":"10.1161\/HYP.0000000000000208","volume":"79","author":"VD Garovic","year":"2022","unstructured":"Garovic VD, Dechend R, Easterling T, Karumanchi SA, McMurtry Baird S, Magee LA, Rana S, Vermunt JV, August P, American Heart Association Council on Hypertension; Council on the Kidney in Cardiovascular Disease, Kidney in Heart Disease Science Committee; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Lifestyle and Cardiometabolic Health; Council on Peripheral Vascular Disease; and Stroke Council (2022) Hypertension in pregnancy: diagnosis, blood pressure goals, and pharmacotherapy: a scientific statement from the American heart association. Hypertension 79(2):e21\u2013e41. https:\/\/doi.org\/10.1161\/HYP.0000000000000208","journal-title":"Hypertension"},{"issue":"2","key":"803_CR61","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12020431","volume":"12","author":"C Garrido-Gim\u00e9nez","year":"2023","unstructured":"Garrido-Gim\u00e9nez C, Cruz-Lemini M, \u00c1lvarez FV, Nan MN, Carretero F, Fern\u00e1ndez-Oliva A, Mora J, S\u00e1nchez-Garc\u00eda O, Garc\u00eda-Osuna \u00c1, Alijotas-Reig J, Llurba E, On Behalf Of The EuroPE Working Group (2023) Predictive model for preeclampsia combining sFlt-1, PlGF, NT-proBNP, and uric acid as biomarkers. J Clin Med 12(2):431. https:\/\/doi.org\/10.3390\/jcm12020431","journal-title":"J Clin Med"},{"issue":"6","key":"803_CR62","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/s00018-022-04377-0","volume":"79","author":"M Gauster","year":"2022","unstructured":"Gauster M, Moser G, Wernitznig S, Kupper N, Huppertz B (2022) Early human trophoblast development: from morphology to function. Cell Mol Life Sci 79(6):345. https:\/\/doi.org\/10.1007\/s00018-022-04377-0","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"803_CR63","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1161\/HYPERTENSIONAHA.115.06071","volume":"67","author":"EE Gillis","year":"2016","unstructured":"Gillis EE, Mooney JN, Garrett MR, Granger JP, Sasser JM (2016) Sildenafil treatment ameliorates the maternal syndrome of preeclampsia and rescues fetal growth in the Dahl salt-sensitive rat. Hypertension 67(3):647\u2013653. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.115.06071","journal-title":"Hypertension"},{"issue":"7","key":"803_CR64","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.tem.2020.03.003","volume":"31","author":"J Gingrich","year":"2020","unstructured":"Gingrich J, Ticiani E, Veiga-Lopez A (2020) Placenta disrupted: endocrine disrupting chemicals and pregnancy. Trends Endocrinol Metab 31(7):508\u2013524. https:\/\/doi.org\/10.1016\/j.tem.2020.03.003","journal-title":"Trends Endocrinol Metab"},{"issue":"1","key":"803_CR65","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s11302-015-9491-2","volume":"12","author":"E Guzm\u00e1n-Guti\u00e9rrez","year":"2016","unstructured":"Guzm\u00e1n-Guti\u00e9rrez E, Armella A, Toledo F, Pardo F, Leiva A, Sobrevia L (2016) Insulin requires A1 adenosine receptors expression to reverse gestational diabetes-increased L-arginine transport in human umbilical vein endothelium. Purinergic Signal 12(1):175\u2013190. https:\/\/doi.org\/10.1007\/s11302-015-9491-2","journal-title":"Purinergic Signal"},{"issue":"3","key":"803_CR66","doi-asserted-by":"publisher","first-page":"283","DOI":"10.2337\/diab.39.3.283","volume":"39","author":"SM Haffner","year":"1990","unstructured":"Haffner SM, Stern MP, Mitchell BD, Hazuda HP, Patterson JK (1990) Incidence of type II diabetes in Mexican Americans predicted by fasting insulin and glucose levels, obesity, and body-fat distribution. Diabetes 39(3):283\u2013288. https:\/\/doi.org\/10.2337\/diab.39.3.283","journal-title":"Diabetes"},{"issue":"2","key":"803_CR67","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.pharmthera.2006.08.003","volume":"113","author":"G Hask\u00f3","year":"2007","unstructured":"Hask\u00f3 G, Pacher P, Deitch EA, Vizi ES (2007) Shaping of monocyte and macrophage function by adenosine receptors. Pharmacol Ther 113(2):264\u2013275. https:\/\/doi.org\/10.1016\/j.pharmthera.2006.08.003","journal-title":"Pharmacol Ther"},{"issue":"1","key":"803_CR68","doi-asserted-by":"publisher","first-page":"24308","DOI":"10.1038\/s41598-025-10576-z","volume":"15","author":"Y He","year":"2025","unstructured":"He Y, Ni Q, Zhang C, Zhou L, Li S, Tao Y, Liu L (2025) GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation. Sci Rep 15(1):24308. https:\/\/doi.org\/10.1038\/s41598-025-10576-z","journal-title":"Sci Rep"},{"key":"803_CR69","doi-asserted-by":"publisher","first-page":"A017","DOI":"10.1161\/hyp.72.suppl_1.017","volume":"72","author":"E Hitzerd","year":"2018","unstructured":"Hitzerd E, Glisic M, Colafella KM, de Vries R, Schoenmakers S, Merkus D, Reiss IK, Danser AH, Simons SH (2018) Effect of sildenafil on nitric oxide-mediated vasodilation in the human placenta: an ex-vivo placental perfusion study. Hypertension 72:A017. https:\/\/doi.org\/10.1161\/hyp.72.suppl_1.017","journal-title":"Hypertension"},{"issue":"10220","key":"803_CR70","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/S0140-6736(19)32973-3","volume":"395","author":"MK Hoffman","year":"2020","unstructured":"Hoffman MK, Goudar SS, Kodkany BS, Metgud M, Somannavar M, Okitawutshu J, Lokangaka A, Tshefu A, Bose CL, Mwapule A, Mwenechanya M, Chomba E, Carlo WA, Chicuy J, Figueroa L, Garces A, Krebs NF, Jessani S, Zehra F, Saleem S, Goldenberg RL, Kurhe K, Das P, Patel A, Hibberd PL, Achieng E, Nyongesa P, Esamai F, Liechty EA, Goco N, Hemingway-Foday J, Moore J, Nolen TL, McClure EM, Koso-Thomas M, Miodovnik M, Silver R, Derman RJ, ASPIRIN Study Group (2020) Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial. Lancet 395(10220):285\u2013293. https:\/\/doi.org\/10.1016\/S0140-6736(19)32973-3","journal-title":"Lancet"},{"issue":"4","key":"803_CR71","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1093\/humupd\/dmae007","volume":"30","author":"M Horvat Mercnik","year":"2024","unstructured":"Horvat Mercnik M, Schliefsteiner C, Sanchez-Duffhues G, Wadsack C (2024) TGF\u03b2 signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy. Hum Reprod Update 30(4):442\u2013471. https:\/\/doi.org\/10.1093\/humupd\/dmae007","journal-title":"Hum Reprod Update"},{"issue":"1","key":"803_CR72","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2023.2183049","volume":"39","author":"E Hosseini","year":"2023","unstructured":"Hosseini E, Mokhtari Z, Salehi Abargouei A, Mishra GD, Amani R (2023) Maternal circulating leptin, tumor necrosis factor-alpha, and interleukine-6 in association with gestational diabetes mellitus: a systematic review and meta-analysis. Gynecol Endocrinol 39(1):2183049. https:\/\/doi.org\/10.1080\/09513590.2023.2183049","journal-title":"Gynecol Endocrinol"},{"issue":"16","key":"803_CR73","doi-asserted-by":"publisher","first-page":"8622","DOI":"10.3390\/ijms22168622","volume":"22","author":"X Hu","year":"2021","unstructured":"Hu X, Zhang L (2021) Uteroplacental circulation in normal pregnancy and preeclampsia: functional adaptation and maladaptation. Int J Mol Sci 22(16):8622. https:\/\/doi.org\/10.3390\/ijms22168622","journal-title":"Int J Mol Sci"},{"issue":"5","key":"803_CR74","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2022.108186","volume":"36","author":"Z Huifen","year":"2022","unstructured":"Huifen Z, Yaping X, Meijing Z, Huibin H, Chunhong L, Fengfeng H, Yaping Z (2022) Effects of moderate-intensity resistance exercise on blood glucose and pregnancy outcome in patients with gestational diabetes mellitus: a randomized controlled trial. J Diabetes Complicat 36(5):108186. https:\/\/doi.org\/10.1016\/j.jdiacomp.2022.108186","journal-title":"J Diabetes Complicat"},{"issue":"6","key":"803_CR75","doi-asserted-by":"publisher","first-page":"H1560","DOI":"10.1152\/ajpheart.00584.2025","volume":"329","author":"N Hula","year":"2025","unstructured":"Hula N, Escalera D, Goulopoulou S (2025) Extracellular vesicles in preeclampsia: drivers of vascular dysfunction and inflammation. Am J Phys 329(6):H1560\u2013H1574. https:\/\/doi.org\/10.1152\/ajpheart.00584.2025","journal-title":"Am J Phys"},{"issue":"6","key":"803_CR76","doi-asserted-by":"publisher","first-page":"953","DOI":"10.3390\/biom10060953","volume":"10","author":"MK Jena","year":"2020","unstructured":"Jena MK, Sharma NR, Petitt M, Maulik D, Nayak NR (2020) Pathogenesis of preeclampsia and therapeutic approaches targeting the placenta. Biomolecules 10(6):953. https:\/\/doi.org\/10.3390\/biom10060953","journal-title":"Biomolecules"},{"issue":"1\u20132","key":"803_CR77","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.jri.2005.10.007","volume":"70","author":"Y Jonsson","year":"2006","unstructured":"Jonsson Y, Rub\u00e8r M, Matthiesen L, Berg G, Nieminen K, Sharma S, Ernerudh J, Ekerfelt C (2006) Cytokine mapping of sera from women with preeclampsia and normal pregnancies. J Reprod Immunol 70(1\u20132):83\u201391. https:\/\/doi.org\/10.1016\/j.jri.2005.10.007","journal-title":"J Reprod Immunol"},{"issue":"1","key":"803_CR78","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1186\/s12933-025-02645-4","volume":"24","author":"Y Jung","year":"2025","unstructured":"Jung Y, Lee SM, Lee J, Kim Y, Lee W, Koo JN, Oh IH, Kang KH, Kim BJ, Kim SM, Lee J, Kim JH, Bae Y, Kim SY, Kim GM, Joo SK, Lee DH, Moon JH, Koo BK, Shin S, Norwitz ER, Hwang GS, Park JS, Kim W (2025) Metabolomic profiling reveals early biomarkers of gestational diabetes mellitus and associated hepatic steatosis. Cardiovasc Diabetol 24(1):125. https:\/\/doi.org\/10.1186\/s12933-025-02645-4","journal-title":"Cardiovasc Diabetol"},{"issue":"2S","key":"803_CR80","doi-asserted-by":"publisher","first-page":"S1182","DOI":"10.1016\/j.ajog.2020.11.029","volume":"226","author":"NA Kametas","year":"2022","unstructured":"Kametas NA, Nzelu D, Nicolaides KH (2022) Chronic hypertension and superimposed preeclampsia: screening and diagnosis. Am J Obstet Gynecol 226(2S):S1182\u2013S1195. https:\/\/doi.org\/10.1016\/j.ajog.2020.11.029","journal-title":"Am J Obstet Gynecol"},{"issue":"4","key":"803_CR81","doi-asserted-by":"publisher","first-page":"BE01","DOI":"10.7860\/JCDR\/2014\/7969.4261","volume":"8","author":"M Kar","year":"2014","unstructured":"Kar M (2014) Role of biomarkers in early detection of preeclampsia. J Clin Diagn Res 8(4):BE01\u2013BBE4. https:\/\/doi.org\/10.7860\/JCDR\/2014\/7969.4261","journal-title":"J Clin Diagn Res"},{"issue":"Suppl 3","key":"803_CR82","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/1471-0528.17607","volume":"130","author":"A Kavi","year":"2023","unstructured":"Kavi A, Hoffman MK, Somannavar MS, Metgud MC, Goudar SS, Moore J, Nielsen E, Goco N, McClure EM, Lokangaka A, Tshefu A, Bauserman M, Mwenechanya M, Chomba E, Carlo WA, Figueroa L, Krebs NF, Jessani S, Saleem S, Goldenberg RL, Das P, Patel A, Hibberd PL, Esamai F, Bucher S, Koso-Thomas M, Silver R, Derman RJ (2023) Aspirin delays the onset of hypertensive disorders of pregnancy among nulliparous pregnant women: a secondary analysis of the ASPIRIN trial. BJOG 130(Suppl 3):16\u201325. https:\/\/doi.org\/10.1111\/1471-0528.17607","journal-title":"BJOG"},{"issue":"1\u20132","key":"803_CR83","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.jri.2012.10.002","volume":"96","author":"A Kestlerov\u00e1","year":"2012","unstructured":"Kestlerov\u00e1 A, Feyereisl J, Frisov\u00e1 V, M\u011bchurov\u00e1 A, \u0160\u016fla K, Zima T, B\u011bl\u00e1\u010dek J, Madar J (2012) Immunological and biochemical markers in preeclampsia. J Reprod Immunol 96(1\u20132):90\u201394. https:\/\/doi.org\/10.1016\/j.jri.2012.10.002","journal-title":"J Reprod Immunol"},{"key":"803_CR84","unstructured":"Khodaee F (2025) Computational modeling of biological function. PhD thesis, Massachusetts Institute of Technology"},{"key":"803_CR85","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.freeradbiomed.2017.01.010","volume":"104","author":"J Kim","year":"2017","unstructured":"Kim J, Lee KS, Kim JH, Lee DK, Park M, Choi S, Park W, Kim S, Choi YK, Hwang JY, Choe J, Won MH, Jeoung D, Lee H, Ryoo S, Ha KS, Kwon YG, Kim YM (2017) Aspirin prevents TNF-\u03b1-induced endothelial cell dysfunction by regulating the NF-\u03baB-dependent miR-155\/eNOS pathway: role of a miR-155\/eNOS axis in preeclampsia. Free Radic Biol Med 104:185\u2013198. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.01.010","journal-title":"Free Radic Biol Med"},{"issue":"12","key":"803_CR86","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9121756","volume":"9","author":"J Kornacki","year":"2021","unstructured":"Kornacki J, Gutaj P, Kalantarova A, Sibiak R, Jankowski M, Wender-Ozegowska E (2021) Endothelial dysfunction in pregnancy complications. Biomedicines 9(12):1756. https:\/\/doi.org\/10.3390\/biomedicines9121756","journal-title":"Biomedicines"},{"issue":"6","key":"803_CR87","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1189\/jlb.0113043","volume":"94","author":"B Koscs\u00f3","year":"2013","unstructured":"Koscs\u00f3 B, Cs\u00f3ka B, K\u00f3kai E, N\u00e9meth ZH, Pacher P, Vir\u00e1g L, Leibovich SJ, Hask\u00f3 G (2013) Adenosine augments IL-10-induced STAT3 signaling in M2c macrophages. J Leukoc Biol 94(6):1309\u20131315. https:\/\/doi.org\/10.1189\/jlb.0113043","journal-title":"J Leukoc Biol"},{"issue":"22","key":"803_CR89","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216082","volume":"24","author":"H Kwon","year":"2023","unstructured":"Kwon H, Jung YJ, Lee Y, Son GH, Kim HO, Maeng YS, Kwon JY (2023) Impaired angiogenic function of fetal endothelial progenitor cells via PCDH10 in gestational diabetes mellitus. Int J Mol Sci 24(22):16082. https:\/\/doi.org\/10.3390\/ijms242216082","journal-title":"Int J Mol Sci"},{"issue":"6","key":"803_CR90","doi-asserted-by":"publisher","first-page":"1577","DOI":"10.2337\/dc12-1731","volume":"36","author":"M Lacroix","year":"2013","unstructured":"Lacroix M, Battista MC, Doyon M, M\u00e9nard J, Ardilouze JL, Perron P, Hivert MF (2013) Lower adiponectin levels at first trimester of pregnancy are associated with increased insulin resistance and higher risk of developing gestational diabetes mellitus. Diabetes Care 36(6):1577\u20131583. https:\/\/doi.org\/10.2337\/dc12-1731","journal-title":"Diabetes Care"},{"issue":"3","key":"803_CR91","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2174\/1570161114666160222115158","volume":"14","author":"A Leiva","year":"2016","unstructured":"Leiva A, Fuenzalida B, Barros E, Sobrevia B, Salsoso R, S\u00e1ez T, Villalobos R, Silva L, Chiarello I, Toledo F, Guti\u00e9rrez J, Sanhueza C, Pardo F, Sobrevia L (2016) Nitric oxide is a central common metabolite in vascular dysfunction associated with diseases of human pregnancy. Curr Vasc Pharmacol 14(3):237\u2013259. https:\/\/doi.org\/10.2174\/1570161114666160222115158","journal-title":"Curr Vasc Pharmacol"},{"key":"803_CR92","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/649070","volume":"2012","author":"J Lepercq","year":"2012","unstructured":"Lepercq J, Lin J, Hall GC, Wang E, Dain MP, Riddle MC, Home PD (2012) Meta-analysis of maternal and neonatal outcomes associated with the use of insulin glargine versus NPH insulin during pregnancy. Obstet Gynecol Int 2012:649070. https:\/\/doi.org\/10.1155\/2012\/649070","journal-title":"Obstet Gynecol Int"},{"issue":"2","key":"803_CR93","doi-asserted-by":"publisher","DOI":"10.31083\/CEOG27065","volume":"52","author":"H Li","year":"2025","unstructured":"Li H, Yin B, Jiang N, Zhu B (2025) Effect of combined gestational diabetes mellitus and preeclampsia on pregnancy outcomes. Clin Exp Obstet Gynecol 52(2):27065. https:\/\/doi.org\/10.31083\/CEOG27065","journal-title":"Clin Exp Obstet Gynecol"},{"issue":"3","key":"803_CR94","doi-asserted-by":"publisher","DOI":"10.1177\/14791641231173627","volume":"20","author":"X Liang","year":"2023","unstructured":"Liang X, Zhang J, Wang Y, Wu Y, Liu H, Feng W, Si Z, Sun R, Hao Z, Guo H, Li X, Xu T, Wang M, Nan Z, Lv Y, Shang X (2023) Comparative study of microvascular structural changes in the gestational diabetic placenta. Diab Vasc Dis Res 20(3):14791641231173627. https:\/\/doi.org\/10.1177\/14791641231173627","journal-title":"Diab Vasc Dis Res"},{"issue":"1","key":"803_CR95","doi-asserted-by":"publisher","DOI":"10.1080\/0167482X.2024.2344079","volume":"45","author":"X Lin","year":"2024","unstructured":"Lin X, Yong J, Gan M, Tang S, Du J (2024) Impact of low-dose aspirin exposure on obstetrical outcomes: a meta-analysis. J Psychosom Obstet Gynaecol 45(1):2344079. https:\/\/doi.org\/10.1080\/0167482X.2024.2344079","journal-title":"J Psychosom Obstet Gynaecol"},{"issue":"1","key":"803_CR96","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1186\/s13098-025-01843-0","volume":"17","author":"S Lingaiah","year":"2025","unstructured":"Lingaiah S, V\u00e4\u00e4r\u00e4sm\u00e4ki M, \u00d6hman H, Kajantie E, Keikkala E, Mustaniemi S (2025) Associations of early pregnancy high-sensitivity C-reactive protein levels with subsequent gestational diabetes: a Finnish gestational diabetes study. Diabetol Metab Syndr 17(1):266. https:\/\/doi.org\/10.1186\/s13098-025-01843-0","journal-title":"Diabetol Metab Syndr"},{"issue":"1","key":"803_CR97","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1186\/s12967-023-04472-1","volume":"21","author":"M Liu","year":"2023","unstructured":"Liu M, Niu Y, Ma K, Leung PCK, Chen ZJ, Wei D, Li Y (2023) Identification of novel first-trimester serum biomarkers for early prediction of preeclampsia. J Transl Med 21(1):634. https:\/\/doi.org\/10.1186\/s12967-023-04472-1","journal-title":"J Transl Med"},{"issue":"3","key":"803_CR98","doi-asserted-by":"publisher","first-page":"372","DOI":"10.2337\/dc18-1646","volume":"42","author":"WL Lowe Jr","year":"2019","unstructured":"Lowe WL Jr, Scholtens DM, Kuang A, Linder B, Lawrence JM, Lebenthal Y, McCance D, Hamilton J, Nodzenski M, Talbot O, Brickman WJ, Clayton P, Ma RC, Tam WH, Dyer AR, Catalano PM, Lowe LP, Metzger BE, HAPO Follow-up Study Cooperative Research Group (2019) Hyperglycemia and Adverse Pregnancy Outcome Follow-Up Study (HAPO FUS): maternal gestational diabetes mellitus and childhood glucose metabolism. Diabetes Care 42(3):372\u2013380. https:\/\/doi.org\/10.2337\/dc18-1646","journal-title":"Diabetes Care"},{"issue":"4","key":"803_CR99","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1007\/s00404-015-3692-3","volume":"292","author":"S Lv","year":"2015","unstructured":"Lv S, Wang J, Xu Y (2015) Safety of insulin analogs during pregnancy: a meta-analysis. Arch Gynecol Obstet 292(4):749\u2013756. https:\/\/doi.org\/10.1007\/s00404-015-3692-3","journal-title":"Arch Gynecol Obstet"},{"key":"803_CR100","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1146\/annurev-cellbio-100814-125620","volume":"31","author":"E Maltepe","year":"2015","unstructured":"Maltepe E, Fisher SJ (2015) Placenta: the forgotten organ. Annu Rev Cell Dev Biol 31:523\u2013552. https:\/\/doi.org\/10.1146\/annurev-cellbio-100814-125620","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"22","key":"803_CR101","doi-asserted-by":"publisher","first-page":"2262","DOI":"10.1001\/jama.2021.7444","volume":"325","author":"T Martens","year":"2021","unstructured":"Martens T, Beck RW, Bailey R, Ruedy KJ, Calhoun P, Peters AL, Pop-Busui R, Philis-Tsimikas A, Bao S, Umpierrez G, Davis G, Kruger D, Bhargava A, Young L, McGill JB, Aleppo G, Nguyen QT, Orozco I, Biggs W, Lucas KJ, Polonsky WH, Buse JB, Price D, Bergenstal RM, MOBILE Study Group (2021) Effect of continuous glucose monitoring on glycemic control in patients with type 2 diabetes treated with basal insulin: a randomized clinical trial. JAMA 325(22):2262\u20132272. https:\/\/doi.org\/10.1001\/jama.2021.7444","journal-title":"JAMA"},{"issue":"3","key":"803_CR102","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/1471-0528.17304","volume":"130","author":"V Mart\u00ednez-Vizca\u00edno","year":"2023","unstructured":"Mart\u00ednez-Vizca\u00edno V, Sanabria-Mart\u00ednez G, Fern\u00e1ndez-Rodr\u00edguez R, Cavero-Redondo I, Pascual-Morena C, \u00c1lvarez-Bueno C, Mart\u00ednez-Hortelano JA (2023) Exercise during pregnancy for preventing gestational diabetes mellitus and hypertensive disorders: an umbrella review of randomised controlled trials and an updated meta-analysis. BJOG 130(3):264\u2013275. https:\/\/doi.org\/10.1111\/1471-0528.17304","journal-title":"BJOG"},{"issue":"4","key":"803_CR103","doi-asserted-by":"publisher","first-page":"771","DOI":"10.2337\/dc06-1887","volume":"30","author":"ER Mathiesen","year":"2007","unstructured":"Mathiesen ER, Kinsley B, Amiel SA, Heller S, McCance D, Duran S, Bellaire S, Raben A, Insulin Aspart Pregnancy Study Group (2007) Maternal glycemic control and hypoglycemia in type 1 diabetic pregnancy: a randomized trial of insulin aspart versus human insulin in 322 pregnant women. Diabetes Care 30(4):771\u2013776. https:\/\/doi.org\/10.2337\/dc06-1887","journal-title":"Diabetes Care"},{"key":"803_CR104","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3389\/fendo.2020.00655","volume":"11","author":"CJ McElwain","year":"2020","unstructured":"McElwain CJ, Tuboly E, McCarthy FP, McCarthy CM (2020) Mechanisms of endothelial dysfunction in pre-eclampsia and gestational diabetes mellitus: windows into future cardiometabolic health? Front Endocrinol (Lausanne) 11:655. https:\/\/doi.org\/10.3389\/fendo.2020.00655","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"5","key":"803_CR105","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1111\/aogs.14523","volume":"102","author":"C McNestry","year":"2023","unstructured":"McNestry C, Killeen SL, Crowley RK, McAuliffe FM (2023) Pregnancy complications and later life women\u2019s health. Acta Obstet Gynecol Scand 102(5):523\u2013531. https:\/\/doi.org\/10.1111\/aogs.14523","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"19","key":"803_CR106","doi-asserted-by":"publisher","first-page":"5736","DOI":"10.3390\/jcm11195736","volume":"11","author":"R Modzelewski","year":"2022","unstructured":"Modzelewski R, Stefanowicz-Rutkowska MM, Matuszewski W, Bandurska-Stankiewicz EM (2022) Gestational diabetes mellitus-recent literature review. J Clin Med 11(19):5736. https:\/\/doi.org\/10.3390\/jcm11195736","journal-title":"J Clin Med"},{"issue":"1","key":"803_CR107","doi-asserted-by":"publisher","first-page":"3","DOI":"10.4093\/dmj.2021.0335","volume":"46","author":"JH Moon","year":"2022","unstructured":"Moon JH, Jang HC (2022) Gestational diabetes mellitus: diagnostic approaches and maternal-offspring complications. Diabetes Metab J 46(1):3\u201314. https:\/\/doi.org\/10.4093\/dmj.2021.0335","journal-title":"Diabetes Metab J"},{"issue":"5","key":"803_CR108","doi-asserted-by":"publisher","first-page":"507","DOI":"10.3109\/14767058.2012.736564","volume":"26","author":"NM Mordwinkin","year":"2013","unstructured":"Mordwinkin NM, Ouzounian JG, Yedigarova L, Montoro MN, Louie SG, Rodgers KE (2013) Alteration of endothelial function markers in women with gestational diabetes and their foetuses. J Matern Fetal Neonatal Med 26(5):507\u2013512. https:\/\/doi.org\/10.3109\/14767058.2012.736564","journal-title":"J Matern Fetal Neonatal Med"},{"key":"803_CR109","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4882061","volume":"2022","author":"A Mu","year":"2022","unstructured":"Mu A, Chen Y, Lv Y, Wang W (2022) Exercise-diet therapy combined with insulin aspart injection for the treatment of gestational diabetes mellitus: a study on clinical effect and its impact. Comput Math Methods Med 2022:4882061. https:\/\/doi.org\/10.1155\/2022\/4882061","journal-title":"Comput Math Methods Med"},{"issue":"1","key":"803_CR110","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/0002-9378(92)91863-6","volume":"166","author":"L Myatt","year":"1992","unstructured":"Myatt L, Brewer AS, Langdon G, Brockman DE (1992) Attenuation of the vasoconstrictor effects of thromboxane and endothelin by nitric oxide in the human fetal-placental circulation. Am J Obstet Gynecol 166(1):224\u2013230. https:\/\/doi.org\/10.1016\/0002-9378(92)91863-6","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"803_CR111","doi-asserted-by":"publisher","first-page":"e91","DOI":"10.1097\/MJT.0000000000001095","volume":"27","author":"A Napoli","year":"2020","unstructured":"Napoli A (2020) Insulin therapy and diabetic pregnancy. Am J Ther 27(1):e91\u2013e105. https:\/\/doi.org\/10.1097\/MJT.0000000000001095","journal-title":"Am J Ther"},{"key":"803_CR112","volume-title":"Hypertension in pregnancy: diagnosis and management","author":"National Institute for Health and Care Excellence (NICE)","year":"2019","unstructured":"National Institute for Health and Care Excellence (NICE) (2019) Hypertension in pregnancy: diagnosis and management. National Institute for Health and Care Excellence (NICE), London. PMID: 31498578"},{"key":"803_CR113","volume-title":"Diabetes in pregnancy: management from preconception to the postnatal period","author":"National Institute for Health and Care Excellence (NICE)","year":"2020","unstructured":"National Institute for Health and Care Excellence (NICE) (2020) Diabetes in pregnancy: management from preconception to the postnatal period. National Institute for Health and Care Excellence (NICE), London. PMID: 32212588"},{"issue":"12","key":"803_CR114","doi-asserted-by":"publisher","first-page":"8260","DOI":"10.4049\/jimmunol.175.12.8260","volume":"175","author":"ZH N\u00e9meth","year":"2005","unstructured":"N\u00e9meth ZH, Lutz CS, Cs\u00f3ka B, Deitch EA, Leibovich SJ, Gause WC, Tone M, Pacher P, Vizi ES, Hask\u00f3 G (2005) Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J Immunol 175(12):8260\u20138270. https:\/\/doi.org\/10.4049\/jimmunol.175.12.8260","journal-title":"J Immunol"},{"issue":"7","key":"803_CR115","doi-asserted-by":"publisher","first-page":"2493","DOI":"10.1021\/acssensors.3c00689","volume":"8","author":"CM Nguyen","year":"2023","unstructured":"Nguyen CM, Sallam M, Islam MS, Clack K, Soda N, Nguyen NT, Shiddiky MJA (2023) Placental exosomes as biomarkers for maternal diseases: current advances in isolation, characterization, and detection. ACS Sens 8(7):2493\u20132513. https:\/\/doi.org\/10.1021\/acssensors.3c00689","journal-title":"ACS Sens"},{"issue":"21","key":"803_CR116","doi-asserted-by":"publisher","first-page":"7731","DOI":"10.3390\/app10217731","volume":"10","author":"A Nikolov","year":"2020","unstructured":"Nikolov A, Popovski N, Hristova I (2020) Collagenases MMP-1, MMP-13, and tissue inhibitors TIMP-1, TIMP-2: their role in healthy and complicated pregnancy and potential as preeclampsia biomarkers\u2014a brief review. Appl Sci 10(21):7731. https:\/\/doi.org\/10.3390\/app10217731","journal-title":"Appl Sci"},{"issue":"2","key":"803_CR117","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2020.101975","volume":"50","author":"R Nirupama","year":"2021","unstructured":"Nirupama R, Divyashree S, Janhavi P, Muthukumar SP, Ravindra PV (2021) Preeclampsia: pathophysiology and management. J Gynecol Obstet Hum Reprod 50(2):101975. https:\/\/doi.org\/10.1016\/j.jogoh.2020.101975","journal-title":"J Gynecol Obstet Hum Reprod"},{"issue":"2","key":"803_CR118","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011880.pub2","volume":"2","author":"SM O\u2019Neill","year":"2017","unstructured":"O\u2019Neill SM, Kenny LC, Khashan AS, West HM, Smyth RM, Kearney PM (2017) Different insulin types and regimens for pregnant women with pre-existing diabetes. Cochrane Database Syst Rev 2(2):CD011880. https:\/\/doi.org\/10.1002\/14651858.CD011880.pub2","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"803_CR119","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ejogrb.2003.07.001","volume":"113","author":"I Ostlund","year":"2004","unstructured":"Ostlund I, Haglund B, Hanson U (2004) Gestational diabetes and preeclampsia. Eur J Obstet Gynecol Reprod Biol 113(1):12\u201316. https:\/\/doi.org\/10.1016\/j.ejogrb.2003.07.001","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"5","key":"803_CR120","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1161\/HYPERTENSIONAHA.117.09690","volume":"70","author":"ND Paauw","year":"2017","unstructured":"Paauw ND, Terstappen F, Ganzevoort W, Joles JA, Gremmels H, Lely AT (2017) Sildenafil during pregnancy: a preclinical meta-analysis on fetal growth and maternal blood pressure. Hypertension 70(5):998\u20131006. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.117.09690","journal-title":"Hypertension"},{"issue":"21","key":"803_CR121","doi-asserted-by":"publisher","first-page":"6390","DOI":"10.3390\/jcm11216390","volume":"11","author":"K Pankiewicz","year":"2022","unstructured":"Pankiewicz K, Szczerba E, Fija\u0142kowska A, Sierdzi\u0144ski J, Issat T, Maciejewski TM (2022) The impact of coexisting gestational diabetes mellitus on the course of preeclampsia. J Clin Med 11(21):6390. https:\/\/doi.org\/10.3390\/jcm11216390","journal-title":"J Clin Med"},{"issue":"2","key":"803_CR122","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/0002-9378(89)90481-X","volume":"160","author":"VM Parisi","year":"1989","unstructured":"Parisi VM, Walsh SW (1989) Fetoplacental vascular responses to prostacyclin after thromboxane-induced vasoconstriction. Am J Obstet Gynecol 160(2):502\u2013507. https:\/\/doi.org\/10.1016\/0002-9378(89)90481-X","journal-title":"Am J Obstet Gynecol"},{"issue":"8","key":"803_CR124","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26083605","volume":"26","author":"K Petkova-Parlapanska","year":"2025","unstructured":"Petkova-Parlapanska K, Kostadinova-Slavova D, Angelova M, Sadi J Al-Dahwi R, Georgieva E, Goycheva P, Karamalakova Y, Nikolova G (2025) Oxidative stress and antioxidant status in pregnant women with gestational diabetes mellitus and late-onset complication of pre-eclampsia. Int J Mol Sci 26(8):3605. https:\/\/doi.org\/10.3390\/ijms26083605","journal-title":"Int J Mol Sci"},{"issue":"10","key":"803_CR125","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1111\/j.1464-5491.2007.02247.x","volume":"24","author":"DJ Pettitt","year":"2007","unstructured":"Pettitt DJ, Ospina P, Howard C, Zisser H, Jovanovic L (2007) Efficacy, safety and lack of immunogenicity of insulin aspart compared with regular human insulin for women with gestational diabetes mellitus. Diabet Med 24(10):1129\u20131135. https:\/\/doi.org\/10.1111\/j.1464-5491.2007.02247.x","journal-title":"Diabet Med"},{"issue":"6","key":"803_CR126","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2215\/CJN.12081115","volume":"11","author":"E Phipps","year":"2016","unstructured":"Phipps E, Prasanna D, Brima W, Jim B (2016) Preeclampsia: updates in pathogenesis, definitions, and guidelines. Clin J Am Soc Nephrol 11(6):1102\u20131113. https:\/\/doi.org\/10.2215\/CJN.12081115","journal-title":"Clin J Am Soc Nephrol"},{"issue":"19","key":"803_CR127","doi-asserted-by":"publisher","first-page":"2020","DOI":"10.1001\/jama.2018.14854","volume":"320","author":"KL Piercy","year":"2018","unstructured":"Piercy KL, Troiano RP, Ballard RM, Carlson SA, Fulton JE, Galuska DA, George SM, Olson RD (2018) The physical activity guidelines for Americans. JAMA 320(19):2020\u20132028. https:\/\/doi.org\/10.1001\/jama.2018.14854","journal-title":"JAMA"},{"issue":"4 Pt A","key":"803_CR129","doi-asserted-by":"publisher","first-page":"1192","DOI":"10.1016\/j.bbadis.2018.01.032","volume":"1864","author":"MA Ram\u00edrez","year":"2018","unstructured":"Ram\u00edrez MA, Morales J, Cornejo M, Blanco EH, Mancilla-Sierpe E, Toledo F, Beltr\u00e1n AR, Sobrevia L (2018) Intracellular acidification reduces l-arginine transport via system y+L but not via system y+\/CATs and nitric oxide synthase activity in human umbilical vein endothelial cells. Biochim Biophys Acta Mol Basis Dis 1864(4 Pt A):1192\u20131202. https:\/\/doi.org\/10.1016\/j.bbadis.2018.01.032","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"803_CR130","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1488127","volume":"15","author":"A Ramos","year":"2024","unstructured":"Ramos A, Youssef L, Molina P, Torramad\u00e9-Moix S, Martinez-Sanchez J, Moreno-Casta\u00f1o AB, Blasco M, Guill\u00e9n-Olmos E, De Moner B, Pino M, Tortajada M, Camacho M, Borrell M, Crovetto F, Ramirez-Bajo MJ, Ventura-Aguiar P, Banon-Maneus E, Rovira J, Escolar G, Carreras E, Gratacos E, Diaz-Ricart M, Crispi F, Palomo M (2024) Circulating extracellular vesicles and neutrophil extracellular traps contribute to endothelial dysfunction in preeclampsia. Front Immunol 15:1488127. https:\/\/doi.org\/10.3389\/fimmu.2024.1488127","journal-title":"Front Immunol"},{"issue":"4","key":"803_CR131","doi-asserted-by":"publisher","first-page":"S9.e1","DOI":"10.1016\/j.ajog.2015.08.003","volume":"213","author":"CW Redman","year":"2015","unstructured":"Redman CW, Staff AC (2015) Preeclampsia, biomarkers, syncytiotrophoblast stress, and placental capacity. Am J Obstet Gynecol 213(4):S9.e1\u2013S9.e4. https:\/\/doi.org\/10.1016\/j.ajog.2015.08.003","journal-title":"Am J Obstet Gynecol"},{"key":"803_CR132","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1111371","volume":"10","author":"Y Ren","year":"2023","unstructured":"Ren Y, Zhao Y, Yang X, Shen C, Luo H (2023) Application of low dose aspirin in pre-eclampsia. Front Med (Lausanne) 10:1111371. https:\/\/doi.org\/10.3389\/fmed.2023.1111371","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"803_CR133","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1515\/jpm-2021-0315","volume":"50","author":"MM Ribeiro","year":"2021","unstructured":"Ribeiro MM, Andrade A, Nunes I (2021) Physical exercise in pregnancy: benefits, risks and prescription. J Perinat Med 50(1):4\u201317. https:\/\/doi.org\/10.1515\/jpm-2021-0315","journal-title":"J Perinat Med"},{"issue":"12","key":"803_CR134","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1056\/NEJM200003233421202","volume":"342","author":"PM Ridker","year":"2000","unstructured":"Ridker PM, Hennekens CH, Buring JE, Rifai N (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N Engl J Med 342(12):836\u2013843. https:\/\/doi.org\/10.1056\/NEJM200003233421202","journal-title":"N Engl J Med"},{"issue":"9","key":"803_CR135","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.2337\/dc09-0688","volume":"32","author":"S Riskin-Mashiah","year":"2009","unstructured":"Riskin-Mashiah S, Younes G, Damti A, Auslender R (2009) First-trimester fasting hyperglycemia and adverse pregnancy outcomes. Diabetes Care 32(9):1639\u20131643. https:\/\/doi.org\/10.2337\/dc09-0688","journal-title":"Diabetes Care"},{"issue":"1","key":"803_CR136","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2017-000456","volume":"6","author":"JA Rowan","year":"2018","unstructured":"Rowan JA, Rush EC, Plank LD, Lu J, Obolonkin V, Coat S, Hague WM (2018) Metformin in gestational diabetes: the offspring follow-up (MiG TOFU): body composition and metabolic outcomes at 7-9 years of age. BMJ Open Diabetes Res Care 6(1):e000456. https:\/\/doi.org\/10.1136\/bmjdrc-2017-000456","journal-title":"BMJ Open Diabetes Res Care"},{"key":"803_CR137","doi-asserted-by":"publisher","first-page":"3253","DOI":"10.1113\/JP290546","volume":"604","author":"M Rudge","year":"2026","unstructured":"Rudge M, Magalhaes C, Fran\u00e7a D, Costa R, Silva K, Calderon I, Sobrevia L (2026) Reframing gestational diabetes mellitus through two new paradigms: early detection and lifelong intergenerational follow-up. J Physiol 604:3253\u20133264. https:\/\/doi.org\/10.1113\/JP290546","journal-title":"J Physiol"},{"issue":"4","key":"803_CR138","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3390\/nu17040680","volume":"17","author":"ML Ruiz-Mart\u00ednez","year":"2025","unstructured":"Ruiz-Mart\u00ednez ML, G\u00f3mez-D\u00edaz RA, Valdez Gonz\u00e1lez AL, \u00c1ngeles Mej\u00eda S, Mondrag\u00f3n Gonz\u00e1lez R, D\u00edaz Flores M, Salda\u00f1a Espinoza RC, Ram\u00edrez-Garc\u00eda LA, D\u00edaz Vel\u00e1zquez MF, Wacher NH (2025) Association of oxidative stress markers with incident hyperglycemia in gestational diabetes mellitus in an educational intervention. Nutrients 17(4):680. https:\/\/doi.org\/10.3390\/nu17040680","journal-title":"Nutrients"},{"key":"803_CR139","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.placenta.2017.01.072","volume":"51","author":"A Saavedra","year":"2017","unstructured":"Saavedra A, Rojas S, Haensgen A, Cid M, Gonz\u00e1lez M, Far\u00edas M, Villalobos-Labra R, Leiva A, Sobrevia L (2017) Maternal obesity associates with foetoplacental vascular dysfunction involving endoplasmic reticulum stress and altered insulin vascular reactivity. Placenta 51:119. https:\/\/doi.org\/10.1016\/j.placenta.2017.01.072","journal-title":"Placenta"},{"issue":"6","key":"803_CR140","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1002\/uog.19040","volume":"51","author":"E Sabri\u00e1","year":"2018","unstructured":"Sabri\u00e1 E, Lequerica-Fern\u00e1ndez P, Lafuente-Ganuza P, Eguia-\u00c1ngeles E, Escudero AI, Mart\u00ednez-Morillo E, Barcel\u00f3 C, \u00c1lvarez FV (2018) Addition of N-terminal pro-B natriuretic peptide to soluble fms-like tyrosine kinase-1\/placental growth factor ratio >\u200938 improves prediction of pre-eclampsia requiring delivery within 1\u2009week: a longitudinal cohort study. Ultrasound Obstet Gynecol 51(6):758\u2013767. https:\/\/doi.org\/10.1002\/uog.19040","journal-title":"Ultrasound Obstet Gynecol"},{"key":"803_CR141","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.placenta.2018.04.010","volume":"66","author":"T S\u00e1ez","year":"2018","unstructured":"S\u00e1ez T, de Vos P, Kuipers J, Sobrevia L, Faas MM (2018) Fetoplacental endothelial exosomes modulate high D-glucose-induced endothelial dysfunction. Placenta 66:26\u201335. https:\/\/doi.org\/10.1016\/j.placenta.2018.04.010","journal-title":"Placenta"},{"issue":"8","key":"803_CR142","first-page":"154","volume":"64","author":"T Saito","year":"2023","unstructured":"Saito T, Suzuki T, Hori Y (2023) Role of sulfatase in adhesion and internalization of Staphylococcus aureus by human corneal epithelial cells. Invest Ophthalmol Vis Sci 64(8):154","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"803_CR143","doi-asserted-by":"publisher","first-page":"598","DOI":"10.2337\/db15-0966","volume":"65","author":"C Salomon","year":"2016","unstructured":"Salomon C, Scholz-Romero K, Sarker S, Sweeney E, Kobayashi M, Correa P, Longo S, Duncombe G, Mitchell MD, Rice GE, Illanes SE (2016) Gestational diabetes mellitus is associated with changes in the concentration and bioactivity of placenta-derived exosomes in maternal circulation across gestation. Diabetes 65(3):598\u2013609. https:\/\/doi.org\/10.2337\/db15-0966","journal-title":"Diabetes"},{"key":"803_CR144","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.mam.2016.12.003","volume":"55","author":"R Salsoso","year":"2017","unstructured":"Salsoso R, Far\u00edas M, Guti\u00e9rrez J, Pardo F, Chiarello DI, Toledo F, Leiva A, Mate A, V\u00e1zquez CM, Sobrevia L (2017) Adenosine and preeclampsia. Mol Asp Med 55:126\u2013139. https:\/\/doi.org\/10.1016\/j.mam.2016.12.003","journal-title":"Mol Asp Med"},{"issue":"1","key":"803_CR145","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165993","volume":"1867","author":"R Salsoso","year":"2021","unstructured":"Salsoso R, Mate A, Toledo F, V\u00e1zquez CM, Sobrevia L (2021) Insulin requires A2B adenosine receptors to modulate the L-arginine\/nitric oxide signalling in the human fetoplacental vascular endothelium from late-onset preeclampsia. Biochim Biophys Acta Mol basis Dis 1867(1):165993. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165993","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"803_CR146","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.placenta.2005.01.011","volume":"27","author":"R San Martin","year":"2006","unstructured":"San Martin R, Sobrevia L (2006) Gestational diabetes and the adenosine\/L-arginine\/nitric oxide (ALANO) pathway in human umbilical vein endothelium. Placenta 27:1\u201310","journal-title":"Placenta"},{"issue":"4","key":"803_CR147","doi-asserted-by":"publisher","first-page":"H1633","DOI":"10.1152\/ajpheart.00575.2004","volume":"288","author":"A Sato","year":"2005","unstructured":"Sato A, Terata K, Miura H, Toyama K, Loberiza FR Jr, Hatoum OA, Saito T, Sakuma I, Gutterman DD (2005) Mechanism of vasodilation to adenosine in coronary arterioles from patients with heart disease. Am J Phys 288(4):H1633\u2013H1640. https:\/\/doi.org\/10.1152\/ajpheart.00575.2004","journal-title":"Am J Phys"},{"issue":"3","key":"803_CR148","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.earlhumdev.2011.08.004","volume":"88","author":"S Schneider","year":"2012","unstructured":"Schneider S, Freerksen N, R\u00f6hrig S, Hoeft B, Maul H (2012) Gestational diabetes and preeclampsia\u2013similar risk factor profiles? Early Hum Dev 88(3):179\u2013184. https:\/\/doi.org\/10.1016\/j.earlhumdev.2011.08.004","journal-title":"Early Hum Dev"},{"issue":"4","key":"803_CR149","doi-asserted-by":"publisher","first-page":"H793","DOI":"10.1152\/ajpheart.00223.2024","volume":"327","author":"KS Schwartz","year":"2024","unstructured":"Schwartz KS, Hernandez PV, Maurer GS, Wetzel EM, Sun M, Jalal DI, Stanhewicz AE (2024) Impaired microvascular insulin-dependent dilation in women with a history of gestational diabetes. Am J Phys 327(4):H793\u2013H803. https:\/\/doi.org\/10.1152\/ajpheart.00223.2024","journal-title":"Am J Phys"},{"issue":"3","key":"803_CR151","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2022.101417","volume":"69","author":"SA Sebastian","year":"2023","unstructured":"Sebastian SA, Co EL, Mehendale M, Hameed M (2023) Insulin analogs in the treatment of type II diabetes and future perspectives. Dis Mon 69(3):101417. https:\/\/doi.org\/10.1016\/j.disamonth.2022.101417","journal-title":"Dis Mon"},{"issue":"1","key":"803_CR152","doi-asserted-by":"crossref","first-page":"17+","DOI":"10.2337\/diaclin.23.1.17","volume":"23","author":"TL Setji","year":"2005","unstructured":"Setji TL, Brown AJ, Feinglos MN (2005) Gestational diabetes mellitus. Clin Diabetes 23(1):17+. Gale OneFile: Health and Medicine, link.gale.com\/apps\/doc\/A128869783\/HRCA?u=anon~ee90dc1a&sid=googleScholar&xid=f2e88a4a. Accessed 17 Apr 2026","journal-title":"Clin Diabetes"},{"issue":"21","key":"803_CR153","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1097\/CM9.0000000000002337","volume":"135","author":"Y Shen","year":"2022","unstructured":"Shen Y, Zheng Y, Su Y, Jiang S, Ma X, Hu J, Li C, Huang Y, Teng Y, Bao Y, Tao M, Zhou J (2022) Insulin sensitivity, \u03b2 cell function, and adverse pregnancy outcomes in women with gestational diabetes. Chin Med J 135(21):2541\u20132546. https:\/\/doi.org\/10.1097\/CM9.0000000000002337","journal-title":"Chin Med J"},{"key":"803_CR154","doi-asserted-by":"publisher","unstructured":"Shi L, Garc\u00eda Zorba CI, Dickerson MA, Bayer CL. Emerging ultrasound-based imaging of the placenta during complications of pregnancy. Placenta 2026. S0143-4004(26) 00089-5 https:\/\/doi.org\/10.1016\/j.placenta.2026.03.011","DOI":"10.1016\/j.placenta.2026.03.011"},{"issue":"9","key":"803_CR155","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s11906-020-01082-w","volume":"22","author":"RG Sinkey","year":"2020","unstructured":"Sinkey RG, Battarbee AN, Bello NA, Ives CW, Oparil S, Tita ATN (2020) Prevention, diagnosis, and management of hypertensive disorders of pregnancy: a comparison of international guidelines. Curr Hypertens Rep 22(9):66. https:\/\/doi.org\/10.1007\/s11906-020-01082-w","journal-title":"Curr Hypertens Rep"},{"key":"803_CR156","doi-asserted-by":"publisher","unstructured":"Smirnakis KV, Plati A, Wolf M, Thadhani R, Ecker JL (2007) Predicting gestational diabetes: choosing the optimal early serum marker. Am J Obstet Gynecol 196(4). https:\/\/doi.org\/10.1016\/j.ajog.2006.12.011","DOI":"10.1016\/j.ajog.2006.12.011"},{"key":"803_CR157","doi-asserted-by":"publisher","unstructured":"Sobrevia L (2026) Endothelial physiology in metabolic diseases: from cells to patients. J Physiol. https:\/\/doi.org\/10.1113\/JP290342","DOI":"10.1113\/JP290342"},{"key":"803_CR158","first-page":"136","volume-title":"Obstetricia","author":"L Sobrevia","year":"2011","unstructured":"Sobrevia L, Casanello P (2011) Placenta. In: P\u00e9rez-S\u00e1nchez A, Donoso-Si\u00f1a E (eds) Obstetricia. Mediterr\u00e1neo, Santiago, pp 136\u2013176"},{"issue":"12","key":"803_CR159","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165948","volume":"1866","author":"L Sobrevia","year":"2020","unstructured":"Sobrevia L, Valero P, Grismaldo A, Villalobos-Labra R, Pardo F, Subiabre M, Armstrong G, Toledo F, Veja S, Cornejo M, Fuentes G, Mar\u00edn R (2020) Mitochondrial dysfunction in the fetoplacental unit in gestational diabetes mellitus. Biochim Biophys Acta Mol basis Dis 1866(12):165948. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165948","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"key":"803_CR160","volume-title":"Foetal programming in obesity and diabetes","author":"L Sobrevia","year":"2026","unstructured":"Sobrevia L, Silva K, Valero P, Catalano P, Casanello P (2026) Obesity in pregnancy and risk and consequences of metabolic diseases. In: Sobrevia L (ed) Foetal programming in obesity and diabetes. Elsevier. The International Union of Physiological Sciences (IUPS) Chapter 2 (In press)"},{"issue":"5","key":"803_CR161","doi-asserted-by":"publisher","first-page":"2227","DOI":"10.1210\/endo.133.5.8404674","volume":"133","author":"RL Sorenson","year":"1993","unstructured":"Sorenson RL, Brelje TC, Roth C (1993) Effects of steroid and lactogenic hormones on islets of Langerhans: a new hypothesis for the role of pregnancy steroids in the adaptation of islets to pregnancy. Endocrinology 133(5):2227\u20132234. https:\/\/doi.org\/10.1210\/endo.133.5.8404674","journal-title":"Endocrinology"},{"key":"803_CR162","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.placenta.2017.08.006","volume":"58","author":"EM Speer","year":"2017","unstructured":"Speer EM, Lin X, Murthy A, Hou W, Islam S, Hanna N (2017) Pentoxifylline inhibits lipopolysaccharide-induced inflammatory mediators in human second trimester placenta explants. Placenta 58:60\u201366. https:\/\/doi.org\/10.1016\/j.placenta.2017.08.006","journal-title":"Placenta"},{"issue":"9741","key":"803_CR163","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1016\/S0140-6736(10)60279-6","volume":"376","author":"EA Steegers","year":"2010","unstructured":"Steegers EA, von Dadelszen P, Duvekot JJ, Pijnenborg R (2010) Pre-eclampsia. Lancet 376(9741):631\u2013644. https:\/\/doi.org\/10.1016\/S0140-6736(10)60279-6","journal-title":"Lancet"},{"issue":"3","key":"803_CR164","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/uog.14799","volume":"45","author":"H Stepan","year":"2015","unstructured":"Stepan H, Herraiz I, Schlembach D, Verlohren S, Brennecke S, Chantraine F, Klein E, Lapaire O, Llurba E, Ramoni A, Vatish M, Wertaschnigg D, Galindo A (2015) Implementation of the sFlt-1\/PlGF ratio for prediction and diagnosis of pre-eclampsia in singleton pregnancy: implications for clinical practice. Ultrasound Obstet Gynecol 45(3):241\u2013246. https:\/\/doi.org\/10.1002\/uog.14799","journal-title":"Ultrasound Obstet Gynecol"},{"issue":"2","key":"803_CR165","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.12.021","volume":"1866","author":"M Subiabre","year":"2020","unstructured":"Subiabre M, Villalobos-Labra R, Silva L, Fuentes G, Toledo F, Sobrevia L (2020) Role of insulin, adenosine, and adipokine receptors in the foetoplacental vascular dysfunction in gestational diabetes mellitus. Biochim Biophys Acta Mol basis Dis 1866(2):165370. https:\/\/doi.org\/10.1016\/j.bbadis.2018.12.021","journal-title":"Biochim Biophys Acta Mol basis Dis"},{"issue":"11","key":"803_CR166","doi-asserted-by":"publisher","first-page":"2695","DOI":"10.1002\/jcp.24993","volume":"230","author":"SA Sultan","year":"2015","unstructured":"Sultan SA, Liu W, Peng Y, Roberts W, Whitelaw D, Graham AM (2015) The role of maternal gestational diabetes in inducing fetal endothelial dysfunction. J Cell Physiol 230(11):2695\u20132705. https:\/\/doi.org\/10.1002\/jcp.24993","journal-title":"J Cell Physiol"},{"issue":"5","key":"803_CR167","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1210\/endrev\/bnac003","volume":"43","author":"A Sweeting","year":"2022","unstructured":"Sweeting A, Wong J, Murphy HR, Ross GP (2022) A clinical update on gestational diabetes mellitus. Endocr Rev 43(5):763\u2013793. https:\/\/doi.org\/10.1210\/endrev\/bnac003","journal-title":"Endocr Rev"},{"key":"803_CR168","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1186\/1471-2172-11-59","volume":"11","author":"A Szarka","year":"2010","unstructured":"Szarka A, Rig\u00f3 J Jr, L\u00e1z\u00e1r L, Beko G, Molvarec A (2010) Circulating cytokines, chemokines and adhesion molecules in normal pregnancy and preeclampsia determined by multiplex suspension array. BMC Immunol 11:59. https:\/\/doi.org\/10.1186\/1471-2172-11-59","journal-title":"BMC Immunol"},{"key":"803_CR169","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.placenta.2020.08.020","volume":"101","author":"K Tenenbaum-Gavish","year":"2020","unstructured":"Tenenbaum-Gavish K, Sharabi-Nov A, Binyamin D, M\u00f8ller HJ, Danon D, Rothman L, Hadar E, Idelson A, Vogel I, Koren O, Nicolaides KH, Gronbaek H, Meiri H (2020) First trimester biomarkers for prediction of gestational diabetes mellitus. Placenta 101:80\u201389. https:\/\/doi.org\/10.1016\/j.placenta.2020.08.020","journal-title":"Placenta"},{"key":"803_CR170","doi-asserted-by":"publisher","unstructured":"Tokic S, Novakovic B, Leopold-Posch B, M\u00fchlberger M, Hoch D, L\u00f6gl J, Bernhart EM, Saffery R, Desoye G, Hiden U (2024) The RhoA guanine exchange factor ABR: a glucose-sensitive mediator of actin reorganization in feto-placental arterial endothelial cells altered by gestational diabetes mellitus. J Physiol. https:\/\/doi.org\/10.1113\/JP285910","DOI":"10.1113\/JP285910"},{"issue":"14","key":"803_CR171","doi-asserted-by":"publisher","first-page":"7569","DOI":"10.3390\/ijms25147569","volume":"25","author":"J Torres-Torres","year":"2024","unstructured":"Torres-Torres J, Espino-Y-Sosa S, Martinez-Portilla R, Borboa-Olivares H, Estrada-Gutierrez G, Acevedo-Gallegos S, Ruiz-Ramirez E, Velasco-Espin M, Cerda-Flores P, Ramirez-Gonzalez A, Rojas-Zepeda L (2024) A narrative review on the pathophysiology of preeclampsia. Int J Mol Sci 25(14):7569. https:\/\/doi.org\/10.3390\/ijms25147569","journal-title":"Int J Mol Sci"},{"key":"803_CR172","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.placenta.2022.03.085","volume":"122","author":"A Valenzuela","year":"2022","unstructured":"Valenzuela A, Guerra C, Mu\u00f1oz F, Cornejo M, Valero P, Sobrevia L (2022) Glycaemic dynamics in women with gestational diabetes mellitus. Placenta 122:21. https:\/\/doi.org\/10.1016\/j.placenta.2022.03.085","journal-title":"Placenta"},{"issue":"7","key":"803_CR173","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagen.2022.130134","volume":"1866","author":"P Valero","year":"2022","unstructured":"Valero P, Salas R, Pardo F, Cornejo M, Fuentes G, Vega S, Grismaldo A, Hillebrands JL, van der Beek EM, van Goor H, Sobrevia L (2022) Glycaemia dynamics in gestational diabetes mellitus. Biochim Biophys Acta Gen Subj 1866(7):130134. https:\/\/doi.org\/10.1016\/j.bbagen.2022.130134","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"4","key":"803_CR174","doi-asserted-by":"publisher","first-page":"C502","DOI":"10.1152\/ajpcell.00137.2018","volume":"315","author":"KM Varberg","year":"2018","unstructured":"Varberg KM, Garretson RO, Blue EK, Chu C, Gohn CR, Tu W, Haneline LS (2018) Transgelin induces dysfunction of fetal endothelial colony-forming cells from gestational diabetic pregnancies. Am J Phys 315(4):C502\u2013C515. https:\/\/doi.org\/10.1152\/ajpcell.00137.2018","journal-title":"Am J Phys"},{"issue":"7","key":"803_CR175","doi-asserted-by":"publisher","first-page":"1627","DOI":"10.3390\/biomedicines13071627","volume":"13","author":"A Varthaliti","year":"2025","unstructured":"Varthaliti A, Lygizos V, Fanaki M, Pergialiotis V, Papapanagiotou A, Pappa K, Theodora M, Daskalaki MA, Antsaklis P, Daskalakis G (2025) The role of IL-6 and TNF-\u03b1 as early biomarkers in the prediction and diagnosis of gestational diabetes mellitus. Biomedicine 13(7):1627. https:\/\/doi.org\/10.3390\/biomedicines13071627","journal-title":"Biomedicine"},{"issue":"Pt 1","key":"803_CR176","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1113\/jphysiol.2004.068288","volume":"560","author":"G V\u00e1squez","year":"2004","unstructured":"V\u00e1squez G, Sanhueza F, V\u00e1squez R, Gonz\u00e1lez M, Mart\u00edn RS, Casanello P, Sobrevia L (2004) Role of adenosine transport in gestational diabetes-induced L-arginine transport and nitric oxide synthesis in human umbilical vein endothelium. J Physiol 560(Pt 1):111\u2013122. https:\/\/doi.org\/10.1113\/jphysiol.2004.068288","journal-title":"J Physiol"},{"issue":"12","key":"803_CR178","doi-asserted-by":"publisher","first-page":"3345","DOI":"10.2337\/dc14-1530","volume":"37","author":"LV Viana","year":"2014","unstructured":"Viana LV, Gross JL, Azevedo MJ (2014) Dietary intervention in patients with gestational diabetes mellitus: a systematic review and meta-analysis of randomized clinical trials on maternal and newborn outcomes. Diabetes Care 37(12):3345\u20133355. https:\/\/doi.org\/10.2337\/dc14-1530","journal-title":"Diabetes Care"},{"key":"803_CR179","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5947859","volume":"2017","author":"R Villalobos-Labra","year":"2017","unstructured":"Villalobos-Labra R, Silva L, Subiabre M, Araos J, Salsoso R, Fuenzalida B, S\u00e1ez T, Toledo F, Gonz\u00e1lez M, Quezada C, Pardo F, Chiarello DI, Leiva A, Sobrevia L (2017) Akt\/mTOR role in human foetoplacental vascular insulin resistance in diseases of pregnancy. J Diabetes Res 2017:5947859. https:\/\/doi.org\/10.1155\/2017\/5947859","journal-title":"J Diabetes Res"},{"issue":"22","key":"803_CR180","doi-asserted-by":"publisher","DOI":"10.3390\/ijms252212195","volume":"25","author":"I Vornic","year":"2024","unstructured":"Vornic I, Buciu V, Furau CG, Gaje PN, Ceausu RA, Dumitru CS, Barb AC, Novacescu D, Cumpanas AA, Latcu SC, Cut TG, Zara F (2024) Oxidative stress and placental pathogenesis: a contemporary overview of potential biomarkers and emerging therapeutics. Int J Mol Sci 25(22):12195. https:\/\/doi.org\/10.3390\/ijms252212195","journal-title":"Int J Mol Sci"},{"issue":"9","key":"803_CR181","doi-asserted-by":"publisher","first-page":"2101","DOI":"10.1038\/s41423-021-00739-z","volume":"18","author":"F Wang","year":"2021","unstructured":"Wang F, Qualls AE, Marques-Fernandez L, Colucci F (2021) Biology and pathology of the uterine microenvironment and its natural killer cells. Cell Mol Immunol 18(9):2101\u20132113. https:\/\/doi.org\/10.1038\/s41423-021-00739-z","journal-title":"Cell Mol Immunol"},{"key":"803_CR183","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2021.109050","volume":"183","author":"H Wang","year":"2022","unstructured":"Wang H, Li N, Chivese T, Werfalli M, Sun H, Yuen L, Hoegfeldt CA, Elise Powe C, Immanuel J, Karuranga S, Divakar H, Levitt N, Li C, Simmons D, Yang X, IDF Diabetes Atlas Committee Hyperglycaemia in Pregnancy Special Interest Group (2022) IDF Diabetes Atlas: estimation of global and regional gestational diabetes mellitus prevalence for 2021 by international association of diabetes in Pregnancy Study Group\u2019s Criteria. Diabetes Res Clin Pract 183:109050. https:\/\/doi.org\/10.1016\/j.diabres.2021.109050","journal-title":"Diabetes Res Clin Pract"},{"issue":"5","key":"803_CR184","doi-asserted-by":"publisher","first-page":"1640","DOI":"10.1210\/endo.137.5.8612496","volume":"137","author":"AJ Weinhaus","year":"1996","unstructured":"Weinhaus AJ, Stout LE, Sorenson RL (1996) Glucokinase, hexokinase, glucose transporter 2, and glucose metabolism in islets during pregnancy and prolactin-treated islets in vitro: mechanisms for long term up-regulation of islets. Endocrinology 137(5):1640\u20131649. https:\/\/doi.org\/10.1210\/endo.137.5.8612496","journal-title":"Endocrinology"},{"issue":"6","key":"803_CR185","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.2337\/db11-0155","volume":"60","author":"F Westermeier","year":"2011","unstructured":"Westermeier F, Salom\u00f3n C, Gonz\u00e1lez M, Puebla C, Guzm\u00e1n-Guti\u00e9rrez E, Cifuentes F, Leiva A, Casanello P, Sobrevia L (2011) Insulin restores gestational diabetes mellitus-reduced adenosine transport involving differential expression of insulin receptor isoforms in human umbilical vein endothelium. Diabetes 60(6):1677\u20131687. https:\/\/doi.org\/10.2337\/db11-0155","journal-title":"Diabetes"},{"key":"803_CR186","doi-asserted-by":"publisher","first-page":"2317","DOI":"10.3389\/fimmu.2019.02317","volume":"10","author":"F Yang","year":"2019","unstructured":"Yang F, Zheng Q, Jin L (2019) Dynamic function and composition changes of immune cells during normal and pathological pregnancy at the maternal-fetal interface. Front Immunol 10:2317. https:\/\/doi.org\/10.3389\/fimmu.2019.02317","journal-title":"Front Immunol"},{"issue":"1","key":"803_CR187","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001310","volume":"8","author":"MN Yang","year":"2020","unstructured":"Yang MN, Chiu HC, Wang WJ, Fang F, Zhang GH, Zhu H, Zhang L, Zhang DL, Du Q, He H, Huang R, Liu X, Li F, Zhang J, Ouyang F, Hua X, Luo ZC (2020) Sex dimorphism in the associations of gestational diabetes with cord blood adiponectin and retinol-binding protein 4. BMJ Open Diabetes Res Care 8(1):e001310. https:\/\/doi.org\/10.1136\/bmjdrc-2020-001310","journal-title":"BMJ Open Diabetes Res Care"},{"issue":"1","key":"803_CR188","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1186\/s12884-024-06651-4","volume":"24","author":"MN Yang","year":"2024","unstructured":"Yang MN, Zhang L, Wang WJ, Huang R, He H, Zheng T, Zhang GH, Fang F, Cheng J, Li F, Ouyang F, Li J, Zhang J, Luo ZC (2024a) Prediction of gestational diabetes mellitus by multiple biomarkers at early gestation. BMC Pregnancy Childbirth 24(1):601. https:\/\/doi.org\/10.1186\/s12884-024-06651-4","journal-title":"BMC Pregnancy Childbirth"},{"key":"803_CR189","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2024.111643","volume":"210","author":"X Yang","year":"2024","unstructured":"Yang X, QimeiZhong, Huang M, Li L, Tang C, Luo S, Wang L, Qi H (2024b) Causal relationship between gestational diabetes and preeclampsia: a bidirectional mendelian randomization analysis. Diabetes Res Clin Pract 210:111643. https:\/\/doi.org\/10.1016\/j.diabres.2024.111643","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"803_CR190","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1186\/s12916-025-04258-w","volume":"23","author":"J Yang","year":"2025","unstructured":"Yang J, Cao Y, Qian F, Grewal J, Sacks DB, Chen Z, Tsai MY, Chen J, Zhang C (2025) Early prediction of gestational diabetes mellitus based on systematically selected multi-panel biomarkers and clinical accessibility-a longitudinal study of a multi-racial pregnant cohort. BMC Med 23(1):430. https:\/\/doi.org\/10.1186\/s12916-025-04258-w","journal-title":"BMC Med"},{"issue":"24","key":"803_CR191","doi-asserted-by":"publisher","first-page":"8553","DOI":"10.26355\/eurrev_201812_16617","volume":"22","author":"HH Ye","year":"2018","unstructured":"Ye HH, Yang SH, Zhang Y (2018) MEG3 damages fetal endothelial function induced by gestational diabetes mellitus via AKT pathway. Eur Rev Med Pharmacol Sci 22(24):8553\u20138560. https:\/\/doi.org\/10.26355\/eurrev_201812_16617","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"803_CR192","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1016\/j.biopha.2017.01.087","volume":"88","author":"Y Yin","year":"2017","unstructured":"Yin Y, Feng Y, Zhao H, Zhao Z, Yua H, Xu J, Che H (2017) SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. Biomed Pharmacother 88:449\u2013458. https:\/\/doi.org\/10.1016\/j.biopha.2017.01.087","journal-title":"Biomed Pharmacother"},{"issue":"5","key":"803_CR193","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1016\/j.ajog.2004.03.074","volume":"191","author":"Y Yogev","year":"2004","unstructured":"Yogev Y, Xenakis EM, Langer O (2004) The association between preeclampsia and the severity of gestational diabetes: the impact of glycemic control. Am J Obstet Gynecol 191(5):1655\u20131660. https:\/\/doi.org\/10.1016\/j.ajog.2004.03.074","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"803_CR194","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1056\/NEJMoa1414838","volume":"374","author":"H Zeisler","year":"2016","unstructured":"Zeisler H, Llurba E, Chantraine F, Vatish M, Staff AC, Sennstr\u00f6m M, Olovsson M, Brennecke SP, Stepan H, Allegranza D, Dilba P, Schoedl M, Hund M, Verlohren S (2016) Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia. N Engl J Med 374(1):13\u201322. https:\/\/doi.org\/10.1056\/NEJMoa1414838","journal-title":"N Engl J Med"},{"issue":"4","key":"803_CR195","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1159\/000447836","volume":"39","author":"J Zhou","year":"2016","unstructured":"Zhou J, Ni X, Huang X, Yao J, He Q, Wang K, Duan T (2016) Potential role of hyperglycemia in fetoplacental endothelial dysfunction in gestational diabetes mellitus. Cell Physiol Biochem 39(4):1317\u20131328. https:\/\/doi.org\/10.1159\/000447836","journal-title":"Cell Physiol Biochem"},{"issue":"8","key":"803_CR196","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2337\/db21-1093","volume":"71","author":"Y Zhu","year":"2022","unstructured":"Zhu Y, Barupal DK, Ngo AL, Quesenberry CP, Feng J, Fiehn O, Ferrara A (2022) Predictive metabolomic markers in early to mid-pregnancy for gestational diabetes mellitus: a prospective test and validation study. Diabetes 71(8):1807\u20131817. https:\/\/doi.org\/10.2337\/db21-1093","journal-title":"Diabetes"},{"key":"803_CR197","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/549412","volume":"2015","author":"A Zimna","year":"2015","unstructured":"Zimna A, Kurpisz M (2015) Hypoxia-inducible factor-1 in physiological and pathophysiological angiogenesis: applications and therapies. Biomed Res Int 2015:549412. https:\/\/doi.org\/10.1155\/2015\/549412","journal-title":"Biomed Res Int"}],"container-title":["Handbook of Experimental Pharmacology"],"original-title":[],"link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/164_2026_803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T19:28:41Z","timestamp":1779132521000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/164_2026_803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":189,"URL":"https:\/\/doi.org\/10.1007\/164_2026_803","relation":{},"ISSN":["0171-2004","1865-0325"],"issn-type":[{"value":"0171-2004","type":"print"},{"value":"1865-0325","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"19 May 2026","order":1,"name":"first_online","label":"First Online","group":{"name":"ChapterHistory","label":"Chapter History"}}]}}