{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T16:17:34Z","timestamp":1777565854251,"version":"3.51.4"},"publisher-location":"Vienna","reference-count":189,"publisher":"Springer Vienna","isbn-type":[{"value":"9783211282533","type":"print"},{"value":"9783211322345","type":"electronic"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006]]},"DOI":"10.1007\/3-211-32234-5_1","type":"book-chapter","created":{"date-parts":[[2006,3,23]],"date-time":"2006-03-23T06:40:15Z","timestamp":1143096015000},"page":"3-32","source":"Crossref","is-referenced-by-count":7,"title":["Gene Technology Based Therapies in the Brain"],"prefix":"10.1007","author":[{"given":"T.","family":"Wirth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yl\u00e4-Herttuala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","reference":[{"key":"1_CR1","unstructured":"Abeloff MD et al (2000) Clinical oncology, 2nd edn. Churchill, Livinstone"},{"issue":"17","key":"1_CR2","doi-asserted-by":"publisher","first-page":"2315","DOI":"10.1089\/104303400750038435","volume":"11","author":"J.A. Alisky","year":"2000","unstructured":"Alisky JA, Davidson BL (2000) Gene therapy for amyotrophic lateral sclerosis and other motor neuron diseases. Hum Gene Ther 11(17): 2315\u20132330","journal-title":"Hum Gene Ther"},{"issue":"2","key":"1_CR3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1227\/00006123-198708000-00012","volume":"21","author":"M. Ammirati","year":"1987","unstructured":"Ammirati M et al (1987) Effect of the extent of surgical resection on survival and quality of life in patients with supratentorial glioblastomas and anaplastic astrocytomas. Neurosurgery 21(2): 201\u2013206","journal-title":"Neurosurgery"},{"issue":"3","key":"1_CR4","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1089\/10430340360535751","volume":"14","author":"D.M. Anderson","year":"2003","unstructured":"Anderson DM et al (2003) Stability of mRNA\/cationic lipid lipoplex in human and rat cerebrospinal fluid: methods and evidence for non-viral mRNA gene delivery into the central nervous system. Hum Gene Ther 14(3): 191\u2013202","journal-title":"Hum Gene Ther"},{"issue":"9","key":"1_CR5","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1089\/104303402753812458","volume":"13","author":"G. Ascadi","year":"2002","unstructured":"Ascadi G et al (2002) Increased survival and function of SOD 1 mice after glial-cell derived neurotrophic factor gene therapy. Hum Gene Ther 13(9): 1047\u20131059","journal-title":"Hum Gene Ther"},{"issue":"5","key":"1_CR6","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/hmg\/9.5.803","volume":"9","author":"M. Azzous","year":"2000","unstructured":"Azzous M et al (2000) Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of adeno-associated virus encoding Bcl-2. Hum Mol Genet 9(5): 803\u2013811","journal-title":"Hum Mol Genet"},{"key":"1_CR7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature02544","volume":"429","author":"M. Azzous","year":"2004","unstructured":"Azzous M et al (2004) VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429: 413\u2013417","journal-title":"Nature"},{"issue":"12","key":"1_CR8","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1089\/10430340050111377","volume":"11","author":"A.C. Bachoud-Levi","year":"2000","unstructured":"Bachoud-Levi AC et al (2000) Neuroprotective gene therapy for Huntington\u2019s disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Hum Gene Ther 11(12): 1723\u20131729","journal-title":"Hum Gene Ther"},{"key":"1_CR9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0079-6123(08)64036-4","volume":"117","author":"A.C. Bachoud-Levi","year":"1998","unstructured":"Bachoud-Levi AC et al (1998) Prospective for cell and gene therapy in Huntington\u2019s disease. Prog Brain Res 117: 511\u2013524","journal-title":"Prog Brain Res"},{"issue":"18","key":"1_CR10","doi-asserted-by":"publisher","first-page":"2987","DOI":"10.1089\/10430349950016393","volume":"10","author":"A.P. Bemelmans","year":"1999","unstructured":"Bemelmans AP et al (1999) Brain-derived neurotrophic factors-mediated protection of striatal neurons in an excitotoxic rat model of Huntington\u2019s disease, demonstrated by adenoviral gene transfer. Hum Gene Ther 10(18): 2987\u20132997","journal-title":"Hum Gene Ther"},{"key":"1_CR11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1161\/01.STR.28.3.609","volume":"28","author":"A. Bethel","year":"1997","unstructured":"Bethel A et al (1997) Intravenous basic fibroblast growth factor-2 decreases brain injury resulting from focal ischemia in cats. Stroke 28: 609\u2013615","journal-title":"Stroke"},{"key":"1_CR12","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1073\/pnas.91.6.2076","volume":"91","author":"R.H. Bobo","year":"1994","unstructured":"Bobo RH et al (1994) Convection-enhanced delivery of macromolecules in the brain. Proc Natl Acad Sci 91: 2076\u20132080","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"1_CR13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tins.2004.03.002","volume":"27","author":"S. Boill\u00e9e","year":"2004","unstructured":"Boill\u00e9e S and Cleveland DW (2004) Gene therapy for ALS delivers. Trends Neurosci 27(5): 235\u2013238","journal-title":"Trends Neurosci"},{"issue":"11","key":"1_CR14","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/sj.gt.3302047","volume":"10","author":"W.J. Bowers","year":"2003","unstructured":"Bowers WJ et al (2003) Immune responses to replication-defective HSV-1 type vectors within the CNS: implication for gene therapy. Gene Ther 10(11): 941\u2013945","journal-title":"Gene Ther"},{"issue":"11","key":"1_CR15","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/S1359-6446(03)02719-3","volume":"8","author":"M. Brown","year":"2003","unstructured":"Brown M (2003) Gene therapy success for Alzheimer\u2019s. Drug Discov Today 8(11): 474\u20135","journal-title":"Drug Discov Today"},{"key":"1_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-5173(01)00861-4","volume":"229","author":"M.D. Brown","year":"2001","unstructured":"Brown MD et al (2001) Gene delivery with synthetic (non-viral) carriers. Int J Pharm 229: 1\u201321","journal-title":"Int J Pharm"},{"key":"1_CR17","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1146\/annurev.neuro.27.070203.144244","volume":"27","author":"L.I. Bruijn","year":"2004","unstructured":"Bruijn LI et al (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu Rev Neurosci 27: 723\u2013749","journal-title":"Annu Rev Neurosci"},{"issue":"4","key":"1_CR18","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/0306-4522(95)00068-T","volume":"66","author":"A.P. Byrnes","year":"1995","unstructured":"Byrnes AP et al (1995) Adenovirus gene transfer causes inflammation in the brain. Neuroscience 66(4): 1015\u20131024","journal-title":"Neuroscience"},{"issue":"4","key":"1_CR19","first-page":"349","volume":"4","author":"M.A. Cabrera-Salazar","year":"2002","unstructured":"Cabrera-Salazar MA et al (2002) Gene therapy for the lysosomal storage disorders. Curr Opin Mol Ther 4(4): 349\u2013358","journal-title":"Curr Opin Mol Ther"},{"key":"1_CR20","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1126\/science.288.5466.669","volume":"288","author":"M. Cavazzana-Calvo","year":"2000","unstructured":"Cavazzana-Calvo M et al (2000) Gene therapy of a human severe combined immunodeficiency (SCID)-XI disease. Science 288: 669\u2013672","journal-title":"Science"},{"issue":"2","key":"1_CR21","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1227\/01.NEU.0000073532.05714.2B","volume":"53","author":"E.A. Chiocca","year":"2003","unstructured":"Chiocca EA (2003) Gene therapy: a primer for neurosurgens. Neurosurgery 53(2): 364\u2013373","journal-title":"Neurosurgery"},{"key":"1_CR22","first-page":"1437","volume-title":"Virology","author":"M. Coffin","year":"1990","unstructured":"Coffin M (1990) Retroviridae and their replication. In: Fields BN, Knipe DM (eds) Virology. Raven Press Ltd, New York, p 1437\u20131500"},{"key":"1_CR23","first-page":"702","volume":"2","author":"T.A. Connors","year":"1995","unstructured":"Connors TA (1995) The choice of prodrugs for gene directed enzyme prodrug therapy of cancer. Gene Ther 2: 702\u2013709","journal-title":"Gene Ther"},{"issue":"16","key":"1_CR24","first-page":"1525","volume":"14","author":"P. Cordelier","year":"2003","unstructured":"Cordelier P et al (2003) Inhibition of HIV-1 in the central nervous system by IFN-alpha2 delivered by an SV40 vector. J Interferon Cytokin Res 14(16): 1525\u20131533","journal-title":"J Interferon Cytokin Res"},{"issue":"1","key":"1_CR25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.expneurol.2003.12.013","volume":"187","author":"M.T. Cruz Da","year":"2004","unstructured":"Da Cruz MT et al (2004) Improving lipoplex-mediated gene transfer into C6 glioma cells and primary neurons. Exp Neurol 187(1): 65\u201375","journal-title":"Exp Neurol"},{"issue":"8","key":"1_CR26","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1038\/sj.cgt.7700724","volume":"11","author":"K. Datta","year":"2004","unstructured":"Datta K et al (2004) Senzitazing glioma cells to cisplatin by abrogating the p53 response with antisense oligonucleotides. Cancer Gene Ther 11(8): 525\u2013531","journal-title":"Cancer Gene Ther"},{"issue":"3","key":"1_CR27","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00006123-200003000-00001","volume":"46","author":"H.H. Dietrich","year":"2000","unstructured":"Dietrich HH and Dacey RG (2000) Molecular keys to the problems of cerebral vasospasm. Neurosurgery 46(3): 517\u201329","journal-title":"Neurosurgery"},{"key":"1_CR28","first-page":"221","volume":"76","author":"M.J. Durin","year":"2003","unstructured":"Durin MJ et al (2003) Development and optimization of adeno-associated virus vector transfer into the central nervous system. Methods Mol Med 76: 221\u2013236","journal-title":"Methods Mol Med"},{"key":"1_CR29","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.266.5189.1399","volume":"266","author":"M.J. During","year":"1994","unstructured":"During MJ et al (1994) Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science 266: 1399\u2013403","journal-title":"Science"},{"issue":"4","key":"1_CR30","first-page":"758","volume":"63","author":"O. Eberhardt","year":"2004","unstructured":"Eberhardt O, Schulz JB (2004) Gene therapy in Parkinson\u2019s disease. Cell Tissue Res 63(4): 758\u2013769","journal-title":"Cell Tissue Res"},{"issue":"6","key":"1_CR31","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1016\/j.ymthe.2003.09.013","volume":"8","author":"J.L. Eberling","year":"2003","unstructured":"Eberling JL et al (2003) In vivo PET imaging of gene expression in parkinsonian monkeys. Mol Ther 8(6): 873\u20135","journal-title":"Mol Ther"},{"issue":"6","key":"1_CR32","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1002\/jgm.619","volume":"6","author":"M.L. Edelstein","year":"2004","unstructured":"Edelstein ML et al (2004) Gene therapy clinical trials worldwide 1989\u20132004 \u2014 an overview. J Gene Med 6(6): 597\u2013602","journal-title":"J Gene Med"},{"key":"1_CR33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1385\/MN:26:2-3:183","volume":"26","author":"M.U. Ehrengruber","year":"2002","unstructured":"Ehrengruber MU (2002) Alphaviral vectors for gene transfer into neurons. Mol Neurobiol 26: 183\u2013201","journal-title":"Mol Neurobiol"},{"issue":"1","key":"1_CR34","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2174\/1566524023363112","volume":"2","author":"Y. Eto","year":"2002","unstructured":"Eto Y, Ohashi T (2002) Novel treatment for neuronopathic lysosomal storage diseases \u2014 cell therapy\/gene therapy. Curr Mol Med 2(1): 83\u201389","journal-title":"Curr Mol Med"},{"key":"1_CR35","first-page":"179","volume":"18","author":"J.K. Fazakerley","year":"2004","unstructured":"Fazakerley JK (2004) Semliki forest virus infection of laboratory mice: a model to study the pathogenesis of viral encephalitis. Arch Virol Suppl 18: 179\u2013190","journal-title":"Arch Virol Suppl"},{"issue":"4","key":"1_CR36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S1052-5149(02)00028-X","volume":"12","author":"P.E. Fecci","year":"2000","unstructured":"Fecci PE, Gromeier M, Sampson JH (2000) Viruses in the treatment of brain tumors. Neuroimaging Clin N Am 12(4): 553\u2013570","journal-title":"Neuroimaging Clin N Am"},{"issue":"11","key":"1_CR37","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1038\/nm1197-1295","volume":"3","author":"F.K. Ferrari","year":"1997","unstructured":"Ferrari FK et al (1997) New developments in the generation of Ad-free, high titer rAAV gene theraby vectors. Nat Med 3(11): 1295\u20131297","journal-title":"Nat Med"},{"issue":"1","key":"1_CR38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1006\/mthe.2000.0229","volume":"3","author":"R. Finkelstein","year":"2001","unstructured":"Finkelstein R, Baughman RW, and Steele FR (2001) Harvesting the neural gene therapy fruit. Mol Ther 3(1): 3\u20137","journal-title":"Mol Ther"},{"key":"1_CR39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/329065a0","volume":"329","author":"W. Fisher","year":"1987","unstructured":"Fisher W (1987) Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329: 65\u201368","journal-title":"Nature"},{"issue":"1","key":"1_CR40","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/sj.gt.3300569","volume":"5","author":"F. Friedlos","year":"1998","unstructured":"Friedlos F et al (1998) Gene directed enzyme prodrug therapy: quantitative bystander cytotoxicity and DNA damage induced by CB 1954 in cells expressing bacterial nitroreductase. Gene Ther 5(1): 105\u2013112","journal-title":"Gene Ther"},{"issue":"24","key":"1_CR41","first-page":"8996","volume":"63","author":"M.A. Friese","year":"2003","unstructured":"Friese MA et al (2003) MICA\/NKG2D-mediated immunogene therapy of experimental gliomas. Cancer Res 63(24): 8996\u20139006","journal-title":"Cancer Res"},{"issue":"7","key":"1_CR42","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1038\/nrm1423","volume":"5","author":"A.H. Futerman","year":"2004","unstructured":"Futerman AH, van Meer G (2004) The cell biology of lysosomal storage disorders. Nat Rev Mol Cell Biol 5(7): 554\u2013565","journal-title":"Nat Rev Mol Cell Biol"},{"key":"1_CR43","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S1054-3589(08)60895-9","volume":"42","author":"D.M. Gash","year":"1998","unstructured":"Gash DM, Gerhardt GA, Hoffer BJ (1998) Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates. Adv Pharmacol 42: 911\u2013915","journal-title":"Adv Pharmacol"},{"issue":"3","key":"1_CR44","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/BF01052628","volume":"26","author":"L. Ge","year":"1995","unstructured":"Ge L et al (1995) Gene therapeutic approaches to primary and metastatic brain tumors: II. Ribozyme-mediated suppression of CD44 expression. J Neurooncol 26(3): 251\u2013257","journal-title":"J Neurooncol"},{"issue":"5","key":"1_CR45","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nbt0597-462","volume":"15","author":"C.K. Goldman","year":"1997","unstructured":"Goldman CK et al (1997) In vitro and in vivo gene delivery mediated by a synthetic polycationic amino polymer. Nat Biotech 15(5): 462\u2013466","journal-title":"Nat Biotech"},{"issue":"10","key":"1_CR46","doi-asserted-by":"publisher","first-page":"1821","DOI":"10.1038\/sj.onc.1207321","volume":"23","author":"C. Gomez-Manzano","year":"2004","unstructured":"Gomez-Manzano C et al (2004) A novel E1A-E1B mutant adenovirus induces glioma regression in vivo. Oncogene 23(10): 1821\u20131828","journal-title":"Oncogene"},{"key":"1_CR47","doi-asserted-by":"publisher","first-page":"4069","DOI":"10.1158\/0008-5472.CAN-04-1243","volume":"64","author":"C.S. Gondi","year":"2004","unstructured":"Gondi CS et al (2004) Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas. Cancer Res 64: 4069\u20134077","journal-title":"Cancer Res"},{"issue":"5587","key":"1_CR48","first-page":"1116","volume":"297","author":"M. Greg","year":"2002","unstructured":"Greg M (2002) Breaking down barriers. Science 297(5587): 1116\u20131118","journal-title":"Science"},{"issue":"5","key":"1_CR49","first-page":"503","volume":"3","author":"M. Gromeier","year":"2001","unstructured":"Gromeier M, Wimmer E (2001) Viruses for the treatment of malignant glioma. Curr Opin Mol Ther 3(5): 503\u2013508","journal-title":"Curr Opin Mol Ther"},{"issue":"2","key":"1_CR50","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/00019052-200404000-00011","volume":"17","author":"E. Gutierrez-Delicado","year":"2004","unstructured":"Gutierrez-Delicado E, Serratosa JM (2004) Genetics of epilepsies. Curr Opin Neurol 17(2): 147\u2013153","journal-title":"Curr Opin Neurol"},{"issue":"8","key":"1_CR51","doi-asserted-by":"publisher","first-page":"1076","DOI":"10.1038\/nm901","volume":"9","author":"R.P. Haberman","year":"2003","unstructured":"Haberman RP et al (2003) Attenuation of seizures and neuronal death by adeno-associated virus vector galanin expression and secretion. Nat Med 9(8): 1076\u20131080","journal-title":"Nat Med"},{"issue":"3","key":"1_CR52","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1056\/NEJM200301163480314","volume":"348","author":"S. Hacein-Bey-Abina","year":"2003","unstructured":"Hacein-Bey-Abina S et al (2003) A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency. N Engl J Med 348(3): 255\u20136","journal-title":"N Engl J Med"},{"key":"1_CR53","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nn863","volume":"5","author":"P. Hagell","year":"2002","unstructured":"Hagell P et al (2002) Dyskinesias following neural transplantation in Parkinsons disease. Nat Neurosci 5: 627\u2013628","journal-title":"Nat Neurosci"},{"issue":"3","key":"1_CR54","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1188\/04.CJON.263-267","volume":"8","author":"M. Haluska","year":"2004","unstructured":"Haluska M, Anthony ML (2004) Osmotic blood-brain barrier modification for the treatment of malignant brain tumors. CJON 8(3): 263\u2013267","journal-title":"CJON"},{"issue":"11","key":"1_CR55","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00004647-200111000-00006","volume":"21","author":"B. Hoehn","year":"2001","unstructured":"Hoehn B et al (2001) Overexpression of HSP72 after induction of experimental stroke protects neurons from ischemic damage. J Cereb Blood Flow Metab 21(11): 1303\u20131309","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"1_CR56","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11910-003-0003-3","volume":"3","author":"P. Hogarth","year":"2003","unstructured":"Hogarth P (2003) Huntington\u2019s disease: a decade beyond gene discovery. Curr Neurol Neurosci Rep 3(4): 279\u2013284","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"10","key":"1_CR57","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1038\/nbt879","volume":"21","author":"K. Howard","year":"2003","unstructured":"Howard K (2003) First Parkinson gene therapy trial launches. Nat. Biotech 21(10): 1117\u20138","journal-title":"Nat. Biotech"},{"issue":"5","key":"1_CR58","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1089\/10430340252837198","volume":"13","author":"G. Hsich","year":"2002","unstructured":"Hsich G, Sena-Esteves M, Breakefield XO (2002) Critical issues in gene therapy for neurologic disease. Hum Gene Ther 13(5): 579\u2013604","journal-title":"Hum Gene Ther"},{"issue":"3","key":"1_CR59","first-page":"864","volume":"61","author":"T. Ichikawa","year":"2001","unstructured":"Ichikawa T et al (2001) Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector. Cancer Res 61(3): 864\u2013868","journal-title":"Cancer Res"},{"issue":"5","key":"1_CR60","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1016\/j.ymthe.2004.08.002","volume":"10","author":"A. Immonen","year":"2004","unstructured":"Immonen A et al (2004) AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomized, controlled study. Mol Ther 10(5): 967\u201372","journal-title":"Mol Ther"},{"issue":"6","key":"1_CR61","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/jnr.10719","volume":"73","author":"J. Jakobsson","year":"2003","unstructured":"Jakobsson J et al (2003) Targeted transgene expression in rat brain using lentiviral vectors. J Neurosci Res 73(6): 876\u2013885","journal-title":"J Neurosci Res"},{"issue":"6","key":"1_CR62","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1002\/jnr.10719","volume":"73","author":"J. Jakobsson","year":"2003","unstructured":"Jakobsson J et al (2003) Targeted transgene expression in rat using lentiviral vectors. J Neurosci Res 73(6): 876\u2013885","journal-title":"J Neurosci Res"},{"issue":"11","key":"1_CR63","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/sj.gt.3302037","volume":"10","author":"K. Joos","year":"2003","unstructured":"Joos K, Chirmule N (2003) Immunity to adenovirus and adenoassociated viral vectors: implications for gene therapy. Gene Ther 10(11): 955\u2013963","journal-title":"Gene Ther"},{"issue":"3","key":"1_CR64","first-page":"253","volume":"103","author":"K. Kajiwara","year":"2000","unstructured":"Kajiwara K et al (2000) Humoral immune response to adenovirus vectors in the brain. J Neuroimmunol 103(3): 253\u2013265","journal-title":"J Neuroimmunol"},{"key":"1_CR65","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1126\/science.1086137","volume":"301","author":"B.K. Kaspar","year":"2003","unstructured":"Kaspar BK et al (2003) Retrograde viral delivery of IGF-1 prolongs survival in a mouse model. Science 301: 839\u2013842","journal-title":"Science"},{"issue":"3","key":"1_CR66","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/S0733-8619(02)00010-5","volume":"20","author":"E.M. Kaye","year":"2002","unstructured":"Kaye EM, Sena-Esteves M (2002) Gene therapy for the central nervous system in the lysosomal storage disorders. Neurol Clin 20(3): 879\u2013901","journal-title":"Neurol Clin"},{"issue":"7","key":"1_CR67","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/S0166-2236(03)00164-4","volume":"26","author":"D. Kirik","year":"2003","unstructured":"Kirik D, Bjorklund A (2003) Modeling CNS neurodegeneration by overexpression of disease causing proteins using viral vectors. Trends Neurosci 26(7): 386\u2013392","journal-title":"Trends Neurosci"},{"key":"1_CR68","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1023\/A:1006487412567","volume":"50","author":"M. Kirsch","year":"2000","unstructured":"Kirsch M et al (2000) Anti-angiogenic treatment strategies for malignant brain tumors. J Neurooncol 50: 149\u2013163","journal-title":"J Neurooncol"},{"issue":"6","key":"1_CR69","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1038\/sj.gt.3301889","volume":"10","author":"J.K. Koponen","year":"2003","unstructured":"Koponen JK et al (2003) Doxycycline-regulated lentiviral vector system with a novel reverse transactivator rtTA2S-M2 shows a tight control of gene expression in vitro and in vivo. Gene Ther 10(6): 459\u2013466","journal-title":"Gene Ther"},{"key":"1_CR70","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1126\/science.290.5492.767","volume":"290","author":"J. Kordower","year":"2000","unstructured":"Kordower J et al (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson\u2019s disease. Science 290: 767\u2013773","journal-title":"Science"},{"issue":"16","key":"1_CR71","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1089\/hum.1996.7.16-1989","volume":"7","author":"C.M. Kramm","year":"1996","unstructured":"Kramm CM et al (1996) Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Ther 7(16): 1989\u20131994","journal-title":"Hum Gene Ther"},{"issue":"4785","key":"1_CR72","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1126\/science.3798108","volume":"235","author":"L.F. Kromer","year":"1987","unstructured":"Kromer LF (1987) Nerve growth factor treatment after brain injury prevents neuronal death. Science 235(4785): 214\u2013216","journal-title":"Science"},{"issue":"4","key":"1_CR73","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/sj.gt.3301905","volume":"10","author":"S. Kugler","year":"2003","unstructured":"Kugler S et al (2003) Human synapsin 1 gene promoter confers highly neuron-specific long-term transgene expression from an adenoviral vector in the adult rat brain depending on the transduced area. Gene Ther 10(4): 337\u2013347","journal-title":"Gene Ther"},{"issue":"10","key":"1_CR74","first-page":"2454","volume":"63","author":"S.S. Lakka","year":"2003","unstructured":"Lakka SS et al (2003) Synergistic down-regulation of urokinase plasminogen activator receptor and matrix metalloproteinase-9 in SNB19 glioblastoma cells efficiently inhibits glioma cell invasion, angiogenesis, and tumor growth. Cancer Res 63(10): 2454\u20132461","journal-title":"Cancer Res"},{"issue":"8","key":"1_CR75","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/BF02725338","volume":"7","author":"J.P. Lamont","year":"2000","unstructured":"Lamont JP et al (2000) A prospective phase II trial of ONYX-015 adenovirus and chemotherapy in recurrent squamous cell carcinoma of the head and neck (the Baylor experience). Ann Surg Oncol 7(8): 588\u2013592","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"1_CR76","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1002\/jgm.245","volume":"4","author":"P. Lampela","year":"2002","unstructured":"Lampela P et al (2002) The use of low-molecular-weight PEIs as gene carriers in the monkey fibroblastoma and rabbit smooth muscle cell culture. J Gene Med 4(2): 205\u2013214","journal-title":"J Gene Med"},{"issue":"24","key":"1_CR77","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1038\/sj.gt.3301854","volume":"9","author":"P. Lehtolainen","year":"2002","unstructured":"Lehtolainen P et al (2002) Baculovirus exhibits restricted cell type specificity in rat brain: a comparison of baculovirus-and adenovirus mediated intracerebral gene transfer in vivo. Gene Ther 9(24): 1693\u20131699","journal-title":"Gene Ther"},{"issue":"10","key":"1_CR78","doi-asserted-by":"publisher","first-page":"8545","DOI":"10.1074\/jbc.M109431200","volume":"277","author":"P. Lehtolainen","year":"2002","unstructured":"Lehtolainen P et al (2002) Clining and characterization of Scavidin, a fusion protein for the targeted delivery of biotinylated molecules. J Biol Chem 277(10): 8545\u20138550","journal-title":"J Biol Chem"},{"issue":"25","key":"1_CR79","doi-asserted-by":"publisher","first-page":"2090","DOI":"10.1038\/sj.gt.3302120","volume":"10","author":"P. Lehtolainen","year":"2003","unstructured":"Lehtolainen P et al (2003) Targeting of biotinylated compounds to its target tissue using a low-density lipoprotein receptor-avidin fusion protein. Gene Ther 10(25): 2090\u20132097","journal-title":"Gene Ther"},{"issue":"2","key":"1_CR80","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0005-2736(02)00474-1","volume":"1564","author":"D. Lesage","year":"2002","unstructured":"Lesage D et al (2002) Evaluation and optimization on DNA delivery into gliosarcoma 9L cells by a cholesterol-based cationic liposome. Biochim Biophys Acta 1564(2): 393\u2013402","journal-title":"Biochim Biophys Acta"},{"issue":"16","key":"1_CR81","doi-asserted-by":"publisher","first-page":"1962","DOI":"10.1161\/01.CIR.0000015365.49180.05","volume":"105","author":"H. Lin","year":"2002","unstructured":"Lin H et al (2002) Cyclooxygenase-1 and bicistronic cyclooxygenase-1\/prostacyclin synthase gene transfer protects against ischemic cerebral infarction. Circulation 105(16): 1962\u20131969","journal-title":"Circulation"},{"issue":"1","key":"1_CR82","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1038\/sj.gt.3302126","volume":"11","author":"B.H. Liu","year":"2004","unstructured":"Liu BH et al (2004) CMV enhancer\/human PDGF-beta promoter for neuron specific transgene expression. Gene Ther 11(1): 52\u201360","journal-title":"Gene Ther"},{"issue":"1","key":"1_CR83","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1080\/07853890310016315","volume":"36","author":"E. Lou","year":"2004","unstructured":"Lou E (2004) Oncolytic viral therapy and immunotherapy of malignant brain tumors: two potential new approaches of translational research. Ann Med 36(1): 2\u20138","journal-title":"Ann Med"},{"issue":"11","key":"1_CR84","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/sj.gt.3302048","volume":"10","author":"P.R. Lowenstein","year":"2003","unstructured":"Lowenstein PR, Castro MG (2003) inflammation and adaptive immune responses to adenoviral vectors injected into the brain: peculiarities, mechanisms, and consequences. Gene Ther 10(11): 946\u2013954","journal-title":"Gene Ther"},{"issue":"1","key":"1_CR85","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/sj.gt.3302186","volume":"11","author":"P.R. Lowenstein","year":"2004","unstructured":"Lowenstein PR (2004) Immunological needles in the gene therapy haystack: applying a genetic paradigm to gene therapy. Gene Ther 11(1): 1\u20133","journal-title":"Gene Ther"},{"issue":"5","key":"1_CR86","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1097\/00006123-200011000-00039","volume":"47","author":"J.C. L\u00fcders","year":"2000","unstructured":"L\u00fcders JC et al (2000) Adenoviral gene transfer of nitric oxide synthase increases cerebral blood flow in rats. Neurosurgery 47(5): 1206\u20131217","journal-title":"Neurosurgery"},{"issue":"3","key":"1_CR87","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0014-5793(01)02707-7","volume":"504","author":"K. Lundstrom","year":"2001","unstructured":"Lundstrom K et al (2001) Semliki Forest virus vectors: efficient vehicles for in vitro and in vivo gene delivery. FEBS Lett 504(3): 99\u2013103","journal-title":"FEBS Lett"},{"key":"1_CR88","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1126\/science.1074549","volume":"298","author":"J. Luo","year":"2002","unstructured":"Luo J et al (2002) Subthalamic GAD gene therapy in a Parkinson\u2019s disease rat model. Science 298: 425\u2013429","journal-title":"Science"},{"issue":"[Suppl] 1","key":"1_CR89","first-page":"88","volume":"1","author":"J.C. MacMillan","year":"1994","unstructured":"MacMillan JC et al (1994) Clinical considerations in gene therapy of Huntington\u2019s disease. Gene Ther 1[Suppl] 1: 88","journal-title":"Gene Ther"},{"issue":"11","key":"1_CR90","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1517\/14712598.4.11.1771","volume":"4","author":"T.J. McCown","year":"2004","unstructured":"McCown TJ (2004) The clinical potential of antiepileptic gene therapy. Expert Opin Biol Ther 4(11): 1771\u20131776","journal-title":"Expert Opin Biol Ther"},{"issue":"1\u20132","key":"1_CR91","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molbrainres.2004.12.007","volume":"135","author":"S.W. McPhee","year":"2005","unstructured":"McPhee SW et al (2005) Effects of AAV-2-mediated aspartoacylase gene transfer in the tremor rat model of Canavan disease. Brain Res Mol Brain Res 135(1\u20132): 112\u2013121","journal-title":"Brain Res Mol Brain Res"},{"issue":"6","key":"1_CR92","first-page":"513","volume":"3","author":"Y. Manome","year":"1996","unstructured":"Manome Y et al (1996) Gene therapy for malignant gliomas using replication incompetent retroviral and adenoviral vectors encoding the cytochrome P450 2B1 gene together with cyclophosphamide. Gene Ther 3(6): 513\u2013520","journal-title":"Gene Ther"},{"issue":"10","key":"1_CR93","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1038\/sj.gt.3301205","volume":"7","author":"J.M. Markert","year":"2000","unstructured":"Markert JM et al (2000) Conditionally replicating herpes simplex virus mutant, GS07 for the treatment of malignant glioma: results of a phase I trial. Gene Ther 7(10): 867\u2013874","journal-title":"Gene Ther"},{"issue":"6","key":"1_CR94","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1523\/JNEUROSCI.23-06-01992.2003","volume":"23","author":"R.A. Marr","year":"2003","unstructured":"Marr RA et al (2003) Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci 23(6): 1992\u20131996","journal-title":"J Neurosci"},{"issue":"1\u20132","key":"1_CR95","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1385\/JMN:22:1-2:5","volume":"22","author":"R.A. Marr","year":"2004","unstructured":"Marr RA et al (2004) Neprilysin regulates amyloid Beta peptide levels. J Mol Neurosci 22(1\u20132): 5\u201311","journal-title":"J Mol Neurosci"},{"key":"1_CR96","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"M.P. Mattson","year":"2004","unstructured":"Mattson MP (2004) Pathways towards and away from Alzheimer\u2019s disease. Nature 430: 631\u2013639","journal-title":"Nature"},{"issue":"2","key":"1_CR97","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/S0014-4886(03)00044-X","volume":"181","author":"J.L. McBride","year":"2003","unstructured":"McBride JL et al (2003) Structural and functional neuroprotection in a rat model of Huntington\u2019s disease by viral gene transfer of GDNF. Exp Neurol 181(2): 213\u2013223","journal-title":"Exp Neurol"},{"issue":"24","key":"1_CR98","first-page":"5738","volume":"58","author":"C.R. Miller","year":"1998","unstructured":"Miller CR et al (1998) Differential susceptibility of primary and established human glioma cells to adenovirus infection: targeting via the epidermal growth factor receptor achieves fibre receptor-independent gene transfer. Cancer Res 58(24): 5738\u20135748","journal-title":"Cancer Res"},{"issue":"3","key":"1_CR99","first-page":"773","volume":"62","author":"C.R. Miller","year":"2002","unstructured":"Miller CR et al (2002) Intratumoral 5-fluorouracil produced by cytosine deaminase\/5-fluorocytosin gene therapy is effective for experimental human glioblastoma. Cancer Res 62(3): 773\u2013780","journal-title":"Cancer Res"},{"key":"1_CR100","doi-asserted-by":"crossref","first-page":"4239","DOI":"10.1128\/MCB.10.8.4239","volume":"10","author":"D.G. Miller","year":"1990","unstructured":"Miller DG et al (1990) Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol Cell Biol 10: 4239\u20134242","journal-title":"Mol Cell Biol"},{"issue":"51","key":"1_CR101","doi-asserted-by":"publisher","first-page":"7824","DOI":"10.1038\/sj.onc.1205893","volume":"21","author":"S. Mohanam","year":"2002","unstructured":"Mohanam S et al (2002) Modulation of invasive properties of human glioblastoma cells stably expressing amino-terminal fragment of urokinase-type plasminogen activator. Oncogene 21(51): 7824\u20137830","journal-title":"Oncogene"},{"issue":"5","key":"1_CR102","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1097\/00062752-200209000-00007","volume":"9","author":"P.E. Monahan","year":"2002","unstructured":"Monahan PE, White GC 2nd (2002) Hemophilia gene therapy: update. Curr Opin Hematol 9(5): 430\u2013436","journal-title":"Curr Opin Hematol"},{"key":"1_CR103","first-page":"279","volume":"1","author":"F.L. Moolten","year":"1994","unstructured":"Moolten FL (1994) Drug sensitivity (\u201csuicide\u201d) genes for selective cancer chemotherapy. Cancer Gene Ther 1: 279\u2013287","journal-title":"Cancer Gene Ther"},{"key":"1_CR104","doi-asserted-by":"crossref","unstructured":"Morishita R et al (2004) Safety Evaluation of Clinical Gene Therapy Using Hepatocyte Growth Factor to Treat Peripheral Arterial Disease. Hypertension Jul 6 [Epub ahead of print]","DOI":"10.1161\/01.HYP.0000136394.08900.ed"},{"issue":"2","key":"1_CR105","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2174\/1566523043346453","volume":"4","author":"R. Morishita","year":"2004","unstructured":"Morishita R et al (2004) Therapeutic angiogenesis using hepatocyte growth factor (HGF). Curr Gene Ther 4(2): 199\u2013206","journal-title":"Curr Gene Ther"},{"issue":"24","key":"1_CR106","first-page":"5731","volume":"58","author":"S. Moriuchi","year":"1998","unstructured":"Moriuchi S et al (1998) Enhanced tumor cell killing in the presence of ganciclovir by herpes simplex virus type 1 vector-directed coexpression of human tumor necrosis factor-alpha and herpes simplex virus thymidine kinase. Cancer Res 58(24): 5731\u20135737","journal-title":"Cancer Res"},{"key":"1_CR107","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0167-7799(99)01416-X","volume":"18","author":"A. Mountain","year":"2000","unstructured":"Mountain A (2000) Gene therapy: the first decade. TIBTECH 18: 119\u2013128","journal-title":"TIBTECH"},{"key":"1_CR108","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1126\/science.272.5259.263","volume":"272","author":"L. Naldini","year":"1996","unstructured":"Naldini L et al (1996) In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science 272: 263\u2013267","journal-title":"Science"},{"issue":"1","key":"1_CR109","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S0140525X00037237","volume":"18","author":"E.A. Neuwelt","year":"1995","unstructured":"Neuwelt EA et al (1995) Gene replacement therapy in the central nervous system \u2014 viral vector-mediated therapy of global neurodegenerative disease. Behav Brain Sci 18(1): 1\u20139","journal-title":"Behav Brain Sci"},{"issue":"1","key":"1_CR110","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1227\/00006123-198007000-00007","volume":"7","author":"G. Neuwelt","year":"1980","unstructured":"Neuwelt G et al (1980) Reversible osmotic blood-brain barrier disruption in humans: implications for the chemotherapy of malignant brain tumors. Neurosurgery 7(1): 44\u201352","journal-title":"Neurosurgery"},{"issue":"3","key":"1_CR111","doi-asserted-by":"crossref","first-page":"584","DOI":"10.3171\/jns.2003.98.3.0584","volume":"98","author":"T.T. Nguyen","year":"2003","unstructured":"Nguyen TT et al (2003) Convective distribution of macromolecules in the primate brain demonstrated using computerized tomography and magnetic resonance imaging. J Neurosurg 98(3): 584\u2013590","journal-title":"J Neurosurg"},{"issue":"8","key":"1_CR112","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1016\/S1359-6446(02)02243-2","volume":"7","author":"M. Ogris","year":"2002","unstructured":"Ogris M, Wagner E (2002) Targeting tumors with non-viral gene delivery systems. Drug Discov Today 7(8): 479\u2013485","journal-title":"Drug Discov Today"},{"key":"1_CR113","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1161\/01.STR.29.9.1959","volume":"29","author":"H. Onoue","year":"1998","unstructured":"Onoue H et al (1998) Expression and function of recombinant endothelial nitric oxide synthase gene in canine basilar artery after experimental subarachnoid hemorrhage. Stroke 29: 1959\u20131966","journal-title":"Stroke"},{"key":"1_CR114","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1016\/S0165-6147(02)02056-4","volume":"23","author":"A.M. Palmer","year":"2002","unstructured":"Palmer AM et al (2002) Pharmacotherapy for Alzheimer\u2019s disease: progress and prospects. Trends Pharmacol Sci 23: 426\u2013433","journal-title":"Trends Pharmacol Sci"},{"issue":"9","key":"1_CR115","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1200\/JCO.2004.10.005","volume":"22","author":"D.H. Palmer","year":"2004","unstructured":"Palmer DH et al (2004) Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitro-reductase to patients with resectable liver cancer. J Clin Oncol 22(9): 1546\u20131552","journal-title":"J Clin Oncol"},{"key":"1_CR116","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0896-6273(02)01054-1","volume":"36","author":"W.M. Pardridge","year":"2002","unstructured":"Pardridge WM (2002) Drug and gene delivery to the brain: the vascular route. Neuron 36: 555\u2013558","journal-title":"Neuron"},{"issue":"4","key":"1_CR117","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/S0896-6273(02)01054-1","volume":"36","author":"W.M. Pardridge","year":"2002","unstructured":"Pardridge WM (2002a) drug and gene delivery to the brain: the vascular route. Neuron 36(4): 555\u2013558","journal-title":"Neuron"},{"issue":"2","key":"1_CR118","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/nrd725","volume":"1","author":"W.M. Pardridge","year":"2002","unstructured":"Pardridge WM (2002b) Drug and gene targeting to the brain with molecular Trojan horses. Nat Rev Drug Discov 1(2): 131\u2013139","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"1_CR119","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1096\/fj.02-0876fje","volume":"17","author":"P.N. Pompl","year":"2003","unstructured":"Pompl PN et al (2003) A therapeutic role for cyclooxygenase-2 inhibitors in a transgenic mouse model of amyotrophic lateral sclerosis. FASEB 17(6): 725\u2013727","journal-title":"FASEB"},{"issue":"3","key":"1_CR120","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1023\/B:NEON.0000003588.18644.9c","volume":"65","author":"M.D. Prados","year":"2003","unstructured":"Prados MD et al (2003) Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I\/II multi-institutional trial. J Neurooncol 65(3): 269\u2013278","journal-title":"J Neurooncol"},{"key":"1_CR121","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/978-1-4419-8871-3_18","volume":"117","author":"V.K. Puduvalli","year":"2004","unstructured":"Puduvalli VK (2004) Inhibition of angiogenesis as a therapeutic strategy against brain tumors. Cancer Treat Res 117: 307\u2013336","journal-title":"Cancer Treat Res"},{"issue":"12","key":"1_CR122","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1089\/hum.1998.9.12-1769","volume":"9","author":"A.M. Puumalainen","year":"1998","unstructured":"Puumalainen AM et al (1998b) Beta-galactosidase gene transfer to human malignant glioma in vivo using replication-deficient retroviruses and adenoviruses. Hum Gene Ther 9(12): 1769\u20131774","journal-title":"Hum Gene Ther"},{"key":"1_CR123","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/978-1-4615-5357-1_78","volume":"451","author":"A.M. Puumalainen","year":"1998","unstructured":"Puumalainen AM, Vapalahti M, Yl\u00e4-Herttuala S (1998a) Gene therapy for malignant glioma patients. Adv Exp Med Biol 451: 505\u2013509","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"1_CR124","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1097\/00006123-200003000-00027","volume":"46","author":"N.H. Qureshi","year":"2000","unstructured":"Qureshi NH et al (2000) Multicolumn infusion of gene therapy cells into human brain tumors: technical report. Neurosurgery 46(3): 663\u2013668; discussion 668\u2013669","journal-title":"Neurosurgery"},{"key":"1_CR125","first-page":"31","volume":"24","author":"I. Rabino","year":"2003","unstructured":"Rabino I (2003) Gene therapy: ethical issues. Theor Med 24: 31\u201358","journal-title":"Theor Med"},{"issue":"17","key":"1_CR126","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1089\/104303400750038499","volume":"11","author":"N.G. Rainov","year":"2000","unstructured":"Rainov NG (2000a) A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 11(17): 2389\u20132401","journal-title":"Hum Gene Ther"},{"issue":"21","key":"1_CR127","doi-asserted-by":"publisher","first-page":"1853","DOI":"10.1038\/sj.gt.3301311","volume":"7","author":"N.G. Rainov","year":"2000","unstructured":"Rainov NG et al (2000b) Immune response induced by retrovirus-mediated HSV-tk\/GCV pharmacogene therapy in patient with glioblastoma multiforme. Gene Ther 7(21): 1853\u20131858","journal-title":"Gene Ther"},{"key":"1_CR128","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2174\/1566523013348445","volume":"1","author":"N.G. Rainov","year":"2001","unstructured":"Rainov NG, Kramm CM (2001) Vector delivery methods and targeting strategies for gene therapy of brain tumors. Curr Gene Ther 1: 367\u2013383","journal-title":"Curr Gene Ther"},{"key":"1_CR129","first-page":"113","volume":"88","author":"N.G. Rainov","year":"2003","unstructured":"Rainov NG, Ren H (2003) Oncolytic viruses for treatment of malignant brain tumours. Acta Neurochir [Suppl] 88: 113\u2013123","journal-title":"Acta Neurochir"},{"issue":"2","key":"1_CR130","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1089\/10430349950019093","volume":"10","author":"N.G. Rainov","year":"1999","unstructured":"Rainov NG et al (1999) Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms. Hum Gene Ther 10(2): 311\u2013318","journal-title":"Hum Gene Ther"},{"issue":"16","key":"1_CR131","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1089\/10430340260355383","volume":"13","author":"E. Regulier","year":"2002","unstructured":"Regulier E et al (2002) Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington\u2019s disease. Hum Gene Ther 13(16): 1981\u20131990","journal-title":"Hum Gene Ther"},{"issue":"12","key":"1_CR132","doi-asserted-by":"publisher","first-page":"3051","DOI":"10.1523\/JNEUROSCI.4056-03.2004","volume":"24","author":"C. Richichi","year":"2004","unstructured":"Richichi C et al (2004) Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus. J Neurosci 24(12): 3051\u20133059","journal-title":"J Neurosci"},{"key":"1_CR133","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1158\/0008-5472.CAN-03-3631","volume":"64","author":"R. Saito","year":"2003","unstructured":"Saito R et al (2003) Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res 64: 2572\u20132579","journal-title":"Cancer Res"},{"key":"1_CR134","doi-asserted-by":"publisher","first-page":"1783","DOI":"10.1016\/S0140-6736(04)16305-8","volume":"363","author":"A. Samii","year":"2004","unstructured":"Samii A, Nutt JG, Ransom BR (2004) Parkinson\u2019s disease. Lancet 363: 1783\u201393","journal-title":"Lancet"},{"issue":"4","key":"1_CR135","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1006\/mthe.2001.0466","volume":"4","author":"R. Sanchez-Pernaut","year":"2001","unstructured":"Sanchez-Pernaut R et al (2001) Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats. Mol Ther 4(4): 324\u2013330","journal-title":"Mol Ther"},{"issue":"16","key":"1_CR136","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1089\/104303400750035726","volume":"11","author":"A.-M. Sandmair","year":"2000","unstructured":"Sandmair A-M et al (2000a) Thymidine kinase gene therapy for human malignant glioma using replication-deficient retroviruses or adenoviruses. Human Gene Ther 11(16): 2197\u20132205","journal-title":"Human Gene Ther"},{"key":"1_CR137","unstructured":"Sandmair A-M (2000b) Gene therapy for malignant glioma. Thesis work. University of Kuopio"},{"key":"1_CR138","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1212\/01.WNL.0000120551.38463.D9","volume":"62","author":"F. Schlachetzki","year":"2004","unstructured":"Schlachetzki F et al (2004) Gene therapy of the brain. Neurology 62: 1275\u20131281","journal-title":"Neurology"},{"key":"1_CR139","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1749-6632.2001.tb11357.x","volume":"953","author":"R. Scollay","year":"2001","unstructured":"Scollay R (2001) Gene therapy: a brief overview of the past, present and future. Ann NY Acad Sci 953: 26\u201330","journal-title":"Ann NY Acad Sci"},{"issue":"1","key":"1_CR140","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neuint.2003.10.009","volume":"45","author":"T. Seki","year":"2004","unstructured":"Seki T et al (2004) Adenoviral gene transfer of aspartoacylase ameliorates tonic convulsions of spontaneously epileptic rats. Neurochem Int 45(1): 171\u2013178","journal-title":"Neurochem Int"},{"issue":"14","key":"1_CR141","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1089\/10430349950016979","volume":"10","author":"N. Shand","year":"1999","unstructured":"Shand N et al (1999) A phase 1\u20132 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group. Hum Gene Therapy 10(14): 2325\u20132335","journal-title":"Hum Gene Therapy"},{"issue":"11","key":"1_CR142","doi-asserted-by":"publisher","first-page":"1509","DOI":"10.1089\/10430340050083243","volume":"11","author":"Y. Shen","year":"2000","unstructured":"Shen Y et al (2000) Triple transduction with adeno-associated virus vectors expressing tyrosine hydroxylase, aromatic-L-amino-acid decarboxylase, and GTP cyclohydrolase I for gene therapy of Parkinson\u2019s disease. Hum Gene Ther 11(11): 1509\u20131519","journal-title":"Hum Gene Ther"},{"key":"1_CR143","unstructured":"Shigeru T et al (2004) Infiltrating macrophages as in vivo targets for intravenous gene delivery in cerebral infarction. Stroke Published online before print"},{"issue":"2","key":"1_CR144","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/S0006-291X(02)02807-3","volume":"300","author":"M. Shimamura","year":"2003","unstructured":"Shimamura M et al (2003) HJV-envelope vector for gene transfer into central nervous system. Biochem Biophys Res Commun 300(2): 464\u2013471","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"1_CR145","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1161\/01.CIR.0000109496.82683.49","volume":"109","author":"M. Shimamura","year":"2004","unstructured":"Shimamura M et al (2004) Novel therapeutic strategy to treat brain ischemia: overexpression of hepatocyte growth factor gene reduced ischemic injury without cerebral edema in rat model. Circulation 109(3): 424\u2013431","journal-title":"Circulation"},{"issue":"2","key":"1_CR146","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1566523034578410","volume":"3","author":"N. Shimoura","year":"2003","unstructured":"Shimoura N, Hamada H (2003) Gene therapy using an adenovirus vector for apoptosis-related genes is a highly effective therapeutic modality for killing glioma cells. Curr Gene Ther 3(2): 147\u2013153","journal-title":"Curr Gene Ther"},{"issue":"9","key":"1_CR147","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1038\/sj.gt.3302224","volume":"11","author":"M. Shirakura","year":"2004","unstructured":"Shirakura M et al (2004) Postischemic administration of Sendai virus vector carrying neurotrophic factor genes prevents delayed neuronal death in gerbils. Gene Ther 11(9): 784\u2013790","journal-title":"Gene Ther"},{"issue":"5","key":"1_CR148","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/S0166-2236(99)01539-8","volume":"23","author":"M. Simonato","year":"2000","unstructured":"Simonato M et al (2000) Gene transfer into neurons for the molecular analysis of behaviour: focus on herpes simplex vectors. Trends Neurosci 23(5): 183\u2013190","journal-title":"Trends Neurosci"},{"issue":"6","key":"1_CR149","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/S1525-0016(03)00100-X","volume":"7","author":"P.S. Smitt","year":"2003","unstructured":"Smitt PS et al (2003) Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir. Mol Ther 7(6): 851\u2013858","journal-title":"Mol Ther"},{"issue":"5","key":"1_CR150","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/S0958-1669(02)00369-5","volume":"13","author":"R.O. Snyder","year":"2002","unstructured":"Snyder RO, Flotte TR (2002) Production of clinical grade recombinant adeno-associated virus vectors. Curr Opin Biotechnol 13(5): 418\u2013423","journal-title":"Curr Opin Biotechnol"},{"issue":"3","key":"1_CR151","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s11910-002-0083-5","volume":"2","author":"J.P. Steinbach","year":"2002","unstructured":"Steinbach JP and Weller M (2002) Mechanisms of apoptosis in central nervous system tumor: application to theory. Curr Neurol Neurosci Rep 2(3): 246\u2013253","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"2","key":"1_CR152","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1038\/84696","volume":"7","author":"D.S. Steinwaerder","year":"2001","unstructured":"Steinwaerder DS et al (2001) Tumor-specific gene expression in hepatic metastases by a replication-activated adenovirus vector. Nat Med 7(2): 240\u2013243","journal-title":"Nat Med"},{"issue":"5","key":"1_CR153","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1097\/00006123-200005000-00034","volume":"46","author":"M. Stoodley","year":"2000","unstructured":"Stoodley M et al (2000) Effect of adenovirus-mediated nitric oxide synthase gene transfer on vasospasm after experimental subarachnoid hemorrhage. Neurosurgery 46(5): 1193\u20131205","journal-title":"Neurosurgery"},{"issue":"11","key":"1_CR154","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1038\/sj.gt.3302039","volume":"10","author":"J.Y. Sun","year":"2003","unstructured":"Sun JY et al (2003) Immune responses to adeno-associated virus and its recombinant vectors. Gene Ther 10(11): 964\u2013976","journal-title":"Gene Ther"},{"issue":"5","key":"1_CR155","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1089\/104303403321467180","volume":"14","author":"M. Sun","year":"2003","unstructured":"Sun M et al (2003) Correction of a rat model of Parkinson\u2019s disease by coexpression of tyrosine hydroxylase and aromatic amino acid decarboxylase from a helper virus-free herpes simplex virus type 1 vector. Hum Gene Ther 14(5): 415\u2013424","journal-title":"Hum Gene Ther"},{"issue":"15","key":"1_CR156","first-page":"3362","volume":"58","author":"T. Tanaka","year":"1998","unstructured":"Tanaka T et al (1998) Viral vector-targeted antiangiogenic gene therapy utilizing an agiostatin complementary DNA. Cancer Res 58(15): 3362\u20133369","journal-title":"Cancer Res"},{"issue":"18","key":"1_CR157","doi-asserted-by":"publisher","first-page":"9799","DOI":"10.1128\/JVI.77.18.9799-9808.2003","volume":"77","author":"H. Tani","year":"2003","unstructured":"Tani H et al (2003) In vitro and in vivo gene delivery by recombinant Baculoviruses. J Virol 77(18): 9799\u20139808","journal-title":"J Virol"},{"key":"1_CR158","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1089\/hum.1990.1.2-111","volume":"1","author":"H.M. Temin","year":"1990","unstructured":"Temin HM (1990) Safety considerations in somatic gene therapy of human disease with retroviral vectors. Human Gene Ther 1: 111\u2013123","journal-title":"Human Gene Ther"},{"key":"1_CR159","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1002\/jgm.506","volume":"6","author":"L. Tenenbaum","year":"2004","unstructured":"Tenenbaum L et al (2004) Recombinant AAV-mediated gene delivery to the central nervous system. J Gene Med 6: 212\u2013222","journal-title":"J Gene Med"},{"key":"1_CR160","first-page":"346","volume":"4","author":"C.E. Thomas","year":"2003","unstructured":"Thomas CE et al (2003) Progress and problems with the use of viral vectors for gene therapy. Nature 4: 346\u2013358","journal-title":"Nature"},{"issue":"6","key":"1_CR161","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1038\/sj.cgt.7700182","volume":"7","author":"T. Todo","year":"2000","unstructured":"Todo T et al (2000) Evaluation of ganciclovir-mediated enhancement of the antitumoral effect in oncolytic, multimediated herpes simplex virus type 1 (G207) therapy of brain tumors. Cancer Gene Ther 7(6): 939\u2013946","journal-title":"Cancer Gene Ther"},{"key":"1_CR162","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1038\/sj.bjp.0705217","volume":"139","author":"K. Toyoda","year":"2003","unstructured":"Toyoda K et al (2003) Gene therapy for cerebral vascular disease: update 2003. Br J Pharmacol 139: 139\u2013147","journal-title":"Br J Pharmacol"},{"issue":"2","key":"1_CR163","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1006\/mthe.2000.0030","volume":"1","author":"T.W. Trask","year":"2000","unstructured":"Trask TW et al (2000) Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther 1(2): 195\u2013203","journal-title":"Mol Ther"},{"key":"1_CR164","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1006\/exnr.1998.6956","volume":"154","author":"M.H. Tuszynski","year":"1998","unstructured":"Tuszynski MH et al (1998) Targeted intraparenchymal delivery of human NGF by gene transfer to the primate forebrain for 3 months does not accelerate \u03b2-amyloid plaque deposition. Exp Neurol 154: 573\u2013582","journal-title":"Exp Neurol"},{"key":"1_CR165","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S1474-4422(02)00006-6","volume":"1","author":"M.H. Tuszynski","year":"2002","unstructured":"Tuszynski MH (2002) Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol 1: 51\u201357","journal-title":"Lancet Neurol"},{"issue":"1","key":"1_CR166","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.ymthe.2004.05.006","volume":"10","author":"H. Uchida","year":"2004","unstructured":"Uchida H et al (2004) Adenovirus-mediated transfer of siRNA against surviving induced apoptosis and attenuated tumor cell growth in vitro and in vivo. Mol Ther 10(1): 162\u2013171","journal-title":"Mol Ther"},{"issue":"18","key":"1_CR167","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1089\/104303403322611809","volume":"14","author":"C. Haute Van der","year":"2003","unstructured":"Van der Haute C et al (2003) Lentiviral vector-mediated delivery of short hairpin RNA results in persistent knockdown of gene expression in mouse brain. Hum Gene Ther 14(18): 1799\u20131807","journal-title":"Hum Gene Ther"},{"issue":"11","key":"1_CR168","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1038\/sj.gt.3302038","volume":"10","author":"H. Wakimoto","year":"2003","unstructured":"Wakimoto H et al (2003) Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Ther 10(11): 983\u2013990","journal-title":"Gene Ther"},{"issue":"16","key":"1_CR169","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1523\/JNEUROSCI.22-16-06920.2002","volume":"22","author":"L.J. Wang","year":"2002","unstructured":"Wang LJ et al (2002) Neuroprotective effects of glial cell-line derived neurotrophic factor mediated by adeno-associated virus in a transgenic animal model of amyotrophic lateral sclerosis. J Neurosci 22(16): 6920\u20136928","journal-title":"J Neurosci"},{"issue":"2","key":"1_CR170","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1161\/01.STR.0000051586.96022.37","volume":"34","author":"Y. Watanabe","year":"2003","unstructured":"Watanabe Y et al (2003) Gene transfer of extracellular superoxide dismutase reduces cerebral vasospasm after subarachnoid hemorrhage. Stroke 34(2): 434\u2013440","journal-title":"Stroke"},{"key":"1_CR171","first-page":"383","volume":"76","author":"D.J. Watson","year":"2003","unstructured":"Watson DJ, Wolfe JH (2003) Lentiviral vectors for gene transfer to the central nervous system. Applications in lysosomal storage disease animal models. Methods Mol Med 76: 383\u2013403","journal-title":"Methods Mol Med"},{"issue":"6","key":"1_CR172","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1002\/(SICI)1097-0215(20000615)86:6<848::AID-IJC14>3.0.CO;2-B","volume":"86","author":"S.J. Weedon","year":"2000","unstructured":"Weedon SJ et al (2000) Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E coli nitroreductase. Int J Cancer 86(6): 848\u2013854","journal-title":"Int J Cancer"},{"issue":"4","key":"1_CR173","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1517\/14656566.5.4.735","volume":"5","author":"M.D. Weiss","year":"2004","unstructured":"Weiss MD et al (2004) Current pharmacological management of amyotrophic [corrected] lateral sclerosis and a role rational polypharmacy. Expert Opin Pharmacother 5(4): 735\u2013746.","journal-title":"Expert Opin Pharmacother"},{"issue":"1","key":"1_CR174","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1038\/nm0103-135","volume":"9","author":"T.J. Wickham","year":"2003","unstructured":"Wickham TJ (2003) Ligand-directed targeting of genes to the site of disease. Nat Med 9(1): 135\u2013139","journal-title":"Nat Med"},{"issue":"6","key":"1_CR175","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/07853899908998799","volume":"31","author":"O. Wildner","year":"1999","unstructured":"Wildner O (1999) In situ use of suicide genes for therapy of brain tumours. Ann Med 31(6): 421\u2013429","journal-title":"Ann Med"},{"key":"1_CR176","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s001090050250","volume":"76","author":"J. Winkler","year":"1998","unstructured":"Winkler J et al (1998) Cholinergic strategies for Alzheimer\u2019s disease. J Mol Med 76: 555\u2013567","journal-title":"J Mol Med"},{"issue":"1\u20132","key":"1_CR177","first-page":"55","volume":"64","author":"T.F. Witham","year":"2003","unstructured":"Witham TF et al (2003) Expression of a soluble transforming growth factorbeta (TGFbeta) receptor reduces tumorigenicity by regulation natural killer (NK) cell activity against 9L gliosarcoma in vivo. J Neurooncol 64(1\u20132): 55\u201361","journal-title":"J Neurooncol"},{"key":"1_CR178","first-page":"82","volume":"1","author":"M.J. Wood","year":"1994","unstructured":"Wood MJ et al (1994) Immunological consequences of HSV-1-mediated gene transfer into the CNS. Gene Ther [Suppl] 1: 82","journal-title":"Gene Ther"},{"issue":"2","key":"1_CR179","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.ymthe.2003.11.010","volume":"9","author":"K. Wu","year":"2004","unstructured":"Wu K et al (2004) The effects of rAAV2-mediated NGF gene delivery in adult and aged rats. Mol Ther 9(2): 262\u2013269","journal-title":"Mol Ther"},{"issue":"4","key":"1_CR180","doi-asserted-by":"crossref","first-page":"746","DOI":"10.3171\/jns.2003.99.4.0746","volume":"99","author":"R. Yamanaka","year":"2003","unstructured":"Yamanaka R et al (2003) Induction of antitumor immunological response by an intratumoral injection of dendritic cells pulsed with genetically engineered Semliki Forest virus to produce interleukin-18 combined with the systemic administration of interleukin-12. J Neurosurg 99(4): 746\u2013753","journal-title":"J Neurosurg"},{"issue":"2","key":"1_CR181","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0006-8993(96)01277-2","volume":"751","author":"G.Y. Yang","year":"1997","unstructured":"Yang GY et al (1997) Overexpression of interleukin-1 receptor antagonist in the mouse brain reduces ischemic brain injury. Brain Res 751(2): 181\u2013188","journal-title":"Brain Res"},{"issue":"6","key":"1_CR182","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1089\/104454904323145263","volume":"23","author":"S.Y. Yang","year":"2004","unstructured":"Yang SY et al (2004) Gene therapy of rat malignant gliomas using neural stem stells expressing IL-12. DNA Cell Biol 23(6): 381\u2013389","journal-title":"DNA Cell Biol"},{"key":"1_CR183","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1749-6632.2003.tb07511.x","volume":"992","author":"M.A. Yenari","year":"2003","unstructured":"Yenari MA et al (2003) Gene therapy and hypothermia for stroke treatment. Ann N Y Acad Sci 992: 54\u201368; discussion 79\u201381","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"1_CR184","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1038\/nm0603-694","volume":"9","author":"S. Yl\u00e4-Herttuala","year":"2003","unstructured":"Yl\u00e4-Herttuala S, Alitalo K (2003) Gene transfer as a tool to induce therapeutic vascular growth. Nat Med 9(6): 694\u2013701","journal-title":"Nat Med"},{"key":"1_CR185","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0140-6736(99)04180-X","volume":"355","author":"S. Yl\u00e4-Herttuala","year":"2000","unstructured":"Yl\u00e4-Herttuala S and Martin JF (2000) Cardiovascular gene therapy. Lancet 355: 213\u2013222","journal-title":"Lancet"},{"key":"1_CR186","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1038\/sj.gt.3301182","volume":"7","author":"H. Yukawa","year":"2000","unstructured":"Yukawa H et al (2000) Adenoviral gene transfer of basic fibroblast growth factor promotes angiogenesis in rat brain. Gene Ther 7: 942\u2013949","journal-title":"Gene Ther"},{"issue":"6","key":"1_CR187","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1227\/01.NEU.0000093425.98136.31","volume":"53","author":"G. Zadeh","year":"2003","unstructured":"Zadeh G and Guha A (2003) Angiogenesis in nervous system disorders. Neurosurgery 53(6): 1362\u20131374","journal-title":"Neurosurgery"},{"issue":"11","key":"1_CR188","doi-asserted-by":"publisher","first-page":"3667","DOI":"10.1158\/1078-0432.CCR-03-0740","volume":"10","author":"Y. Zhang","year":"2004","unstructured":"Zhang Y et al (2004) Intravenous RNA interference gene therapy targeting the human epidermal growth factor receptor prolongs survival in intracranial brain tumour. Clin Cancer Res 10(11): 3667\u20133677","journal-title":"Clin Cancer Res"},{"issue":"4","key":"1_CR189","first-page":"1992","volume":"40","author":"B.V. Zlokovic","year":"1997","unstructured":"Zlokovic BV and Apuzzo M (1997) Cellular and molecular neurosurgery: pathways from concept to reality \u2014 part II: vector systems and delivery methodologies for gene therapy of the central nervous system. Neurosurgery 40(4): 1992\u20131998","journal-title":"Neurosurgery"}],"container-title":["Advances and Technical Standards in Neurosurgery"],"original-title":[],"link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/3-211-32234-5_1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,19]],"date-time":"2019-01-19T04:26:46Z","timestamp":1547872006000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/3-211-32234-5_1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"ISBN":["9783211282533","9783211322345"],"references-count":189,"URL":"https:\/\/doi.org\/10.1007\/3-211-32234-5_1","relation":{},"ISSN":["0095-4829"],"issn-type":[{"value":"0095-4829","type":"print"}],"subject":[],"published":{"date-parts":[[2006]]}}}